Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
By Adam Throne
Research Question
Why do some states have higher opioid prescription rates than other states do? How do
these varying rates impact the prescription opioid abuse epidemic within the United States?
Literature Review
Drug abuse is an increasingly popularized topic within the United States. Movies
involving DEA busts in Latin America and TV shows about meth labs in suburban garages
dominate popular media. A key aspect of health education across America is the danger of drug
abuse. This past weekend, my 9-year old cousin said the following to his older sister who attends
Dartmouth University: “Drugs are bad. Don’t do drugs. Did you know that drugs can kill you?”
Typically, on the national scale, patterns of drug abuse are fairly easy to identify, predict, and
prevent. Recently though, a new drug epidemic has developed within the United States that
challenges this conception. The abuse of prescription drugs, and specifically pharmaceutical
opioids, is growing at an exponential rate. Scholars are baffled by the lack of consistency in
patterns of abuse between states. Existing literature focuses on the scope of the epidemic and
characteristics shared by abusers. However, in order to resolve the opioid epidemic in the United
States, scholars must step back and analyze the pathways through which opioids are introduced
into society. This quantitative study identifies characteristics of states with high prescription
rates. In the future, the findings of this study can be used to prevent the distribution of opioids to
For those unfamiliar with opioids, they are a class of substance that manipulate opioid
receptors in the brain, spine, and digestive system to produce a pain relieving effect (Freye and
Levy 2008; Yaksh and Wallace 2011). In 1874, with the goal of creating a cough suppressant
and sedative, C.R. Alder Wright synthetically derived them for the first time (Yaksh and Wallace
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2011). Today, opioids are commonly prescribed for a variety of pain relief treatments including
surgery, sports injuries, and even cancer treatment (Forbes 2007; Frey and Levy 2008).
Additionally, close to 125 million Americans suffer treatable chronic pain each year (Skolnick
(Vicodin), codeine, and morphine. Sadly, naturally derived from opium poppy, these drugs are
Were prescription opioids solely used for the purposes of their prescriptions, there would
not be an issue to analyze. However, over the past decade there has been an increase in the
number of drug prescriptions, number of drug overdoses, and number of drug fatalities related to
prescription drugs throughout the United States (Calcaterra, Glanz and Binswanger 2013; Rudd
et al. 2016). It is estimated that 3 million people in the United States have a current or past opioid
addiction, and the treatment for such addictions often involves other harmful drugs such as
methadone (Schuckit 2016). On a national level, the abuse of prescription opioids has remained
steady in recent years, but the use of traditional heroin has spiked (Rudd et al. 2016). It seems
In addition to a variety of online forums, several recent studies have attempted to identify
the populations directly susceptible to high opioid abuse rates. Multiple reviews point out how
the prescription drug epidemic, unlike similar epidemics, has spread beyond the confines of
urban epicenters (Hall et al. 2008; Paulozzi and Xi 2008). A recent journal expands this finding
by determining that changes in pharmacy density are significant in rural settings while changes
in income and manual labor industries are significant in suburban and rural settings (Cerda et al.
2017). Although I respect the validity of these statistical discoveries, they seem somewhat
4
narrow and may be extraneous. For this same reason, certain scholars even discredit their own
statistical findings. In December, research journalists from the New York Times determined that
opioid mortality rates are growing at the highest rate for middle-age African American men. The
same article claims that this finding is too specific to discredit the existing theory that opioid
addiction transcends typical dividing factors of race, socioeconomic class, gender, and age (Katz
and Goodnough 2017). Essentially, to the limits of existing literature, all individuals with
A broader explanation is that states with medical or recreational marijuana policies are
less likely to have problems with opioid addiction. Although marijuana is illegal on the federal
level, many believe that it is less addictive than opioids are while still having a pain-relief effect.
Furthermore, it has been proven that self-imposed abuse treatments are more effective than
government controlled ones, such as methadone clinics (Sindelar and Fiellin 2001). For those
worried about the lack of election support for recreational marijuana, there is evidence that states
with medical marijuana laws have an increasing chance of legalizing recreational marijuana
(Kilmer and MacCoun 2017). Nevertheless, many individuals do not support the use or
legalization of marijuana. It is likely that at-risk individuals would continue to use legal
prescription opioids rather than break federal law even if state laws were to legalize marijuana.
Varying state laws, diverse populations, and inter-state movement make it very difficult to
establish a direct correlation between general characteristics and state drug abuse rates.
prescriptions from leaving the pharmacy. When analyzing drug prescription patterns, there is
also clear state-to-state variability (Maxwell 2011). Some states overprescribe prescription drugs
while others under-prescribe them. In general, it seems that prescription patterns vary at the
5
county level (Zhang, Baicker and Newhouse 2010). In many of these counties, the demand for
prescription opioids has no correlation to injury or chronic pain rate (McDonald, Carlson and
Izrael 2013). This fuels the conflict of whether or not governments should intervene at the risk of
unintentionally limiting the supply of legal opioids for those who use them appropriately
(Larance et al. 2011). Before implementing general policies that could further limit necessary
painkiller prescriptions, policymakers must first identify and educate the populations responsible
Limiting the distribution of opioids directly has proven to be a challenge. A 2008 case
study of West Virginia found that pharmaceutical diversion was the cause of over 60% of opioid-
related deaths followed by doctor shopping at around 20% (Hall et al. 2008). Even in states with
strict regulations on the use and prescription of these drugs though, it is very difficult to control
their distribution and consumption once they leave the pharmacy (CDC 2017; Kantor et al.
2015). Prescription drugs, including opioids, are most easily obtained through friends and family
(National Institute on Drug Abuse). With this in mind, there has been a change in focus among
public health officials from preventing the distribution of prescription opioids to learning how to
treat addiction to them (Kolodny et al. 2015; McCarty, Priest and Korthuis 2017). This is
targeting the prescription of opioids. A popular theory when the opioid epidemic first broke out
was that the quality of clinicians and prescription patterns impacted the number of prescriptions
and amount of drug abuse in a region (Hall et al. 2008; Lin et al. 2018; National Institute on
including drug monitoring programs, daily supply limits to written prescriptions, substance abuse
6
disorder assessments, ID checking mandates, and continuous medical education for clinicians
(Athena Insight 2017). Unfortunately, since states have only recently introduced these policies,
they are not useful control variables. States with high prescription rates are more likely to enact
policies targeting high prescription rates. Many of these policies are intended to have long-term
impacts. Current addicts will either find loopholes to obtain prescriptions or transition to illegal
heroin as it becomes more difficult to receive prescriptions for chronic pain. Additionally, the
common dissemination of prescriptions between families and friends questions the effectiveness
of each program, specifically statewide drug monitoring programs (Lin et al. 2018). In order for
policies to be effective, they must be formulated specifically for the individuals who are willing
Theory
characteristics shared by generous opioid prescribers. The American political climate is primarily
bipartisan. Recent studies have favored an expressive party identification model over an
instrumental one (Huddy, Mason and Aarøe 2015). Under this model, strongly identified
partisans feel angrier than weaker partisans when threatened with electoral loss (Huddy, Mason
and Aarøe 2015). This has created a climate in which conservatives and liberals are severely
polarized over key policy conflicts (Lee 2015). This bipolar system poses serious constraints to
policymaking within public health (Oliver 2005). On the individual level, it is even more likely
that individuals will adhere to their own political beliefs than follow the government’s. Liberals
tend to be progressive with respect to drug use (Marietta 2012). Conservatives on the other hand
typically support minimal government intervention, the maintenance of existing policy, and
adherence to traditional values (Marietta 2012). The tendency for conservative voters to live in
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rural settings supports the inconsistency that opioid abuse has spread outside of cities. The
preference of conservative individuals to retain strong ties with family members explains the
medical marijuana favors the promotion of alternative legal prescription painkillers (Republican
Views). Although not all conservative voters share these viewpoints, particularly due to the
radical candidates of the previous few elections, there should be consistency on the statewide
scale.
Therefore, due to their traditional preferences, conservative voters are more likely to
support the prescription of opioids for chronic pain than liberal voters are. Thus, states with more
conservative voters tend to distribute more prescriptions of opioids than states with fewer
conservative voters do. Due to the fact that the opioid epidemic is a current and growing national
issue, existing solutions are incomplete and evolving. If the results of my study are significant,
they will provide a significant contribution towards identifying the populations which must be
Data
Due to the fact that the prescription opioid epidemic is still an emerging issue within the
reports. Independent variables associated with population demographics are collected from more
conventional well-respected sources including the United States Census. For each variable, data
is sorted by state.
To measure the political identity of each state, I use ratios calculated from the 2016
presidential election. I choose to represent this variable with presidential election results for two
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reasons. First, presidential elections produce the highest voter turnout due to their large
implications and widespread media attention. Second, uneducated voters tend to vote more
consistently with their individual ideological stances than their partisan preferences in
presidential elections (Huddy, Mason and Aarøe 2015). I choose the 2016 election, because it is
the most recent election. Lack of partisan support for both Hillary Clinton and Donald Trump
may impact these results. In a future study, I would suggest using average election percentages
from presidential elections of the past twenty years. However, variation between elections is
small enough that the general trends and correlations I predict should not be affected. Official
election data is available through the Federal Election Commission (Federal Election
Commission 2016). My dataset includes a column for percent of voters in each state who voted
“conservative”, “liberal”, and “other.” These percentages are calculated manually using a
spreadsheet function.
To measure the prescription rate of each state, my dependent variable, I use data from the
Center for Disease Control (Center for Disease Control 2017). Rather than calculating a mean
from multiple years of data, I use the dataset available from 2015. This is a recent dataset that
also represents the peak of the opioid epidemic. This allows me to accurately analyze the impact
Additionally, the year of the dataset fits well with the election data chosen for my primary
In order to ensure the validity of the study’s hypothesis, it is essential to address other
unrelated variables which may impact the study’s dependent variable. Wealthy individuals are
capable of purchasing more prescriptions, so wealthy states may have larger prescription rates.
9
Alternatively, wealthy individuals have more access to drug education and materials highlighting
the dangers of prescription opioids. In such a case, wealthy states would have lower prescription
rates. I control for these scenarios by including a Median Household Income column. Data
associated with this control variable was collected by the United States Census in 2016. I divide
each value by 1000 to make results more consistent with an individual’s typical change in
income.
States with large populations tend to have greater ideological variability than states with
small populations. Initial testing demonstrates that without controlling for population, New York
and Texas, states with 2 of the nation’s 3 largest populations, are significant outliers. Using rate
measurements rather than total counts for my key variables helps eliminate some state-to-state
population variability. In order to ensure that this imbalance does not reduce the effectiveness of
my model though, I include state population as a control variable. Data for this control variable
was collected by the United States Census in 2016. I divide each value by 1000, because a 1000
person change in population is more likely and significant than a 1 person change on a state
level.
Participation in workforce likely impacts opioid prescription rates. Individuals who are
working or looking for jobs have less time to be under the influence of opioid painkillers or any
other substance. Thereby, states with high labor participation rates should have lower
prescription rates than states with low labor participation rates. Alternatively, individuals who
work more are more likely to be in pain. Accordingly, states with high labor participation rates
should have higher opioid prescription rates for chronic pain. I control for these likelihoods by
including a “participation rate in the economy” column. Data for this control variable was
A variable that has a significant impact on similar social variables, including other types
of drug abuse, is race. Typically, African Americans and Latinos are more likely to abuse street
drugs such as heroin. However, literature on opioid abuse claims that race does not have an
influence in this case. In order to prove this widely supported claim, I include a column for race.
I bundle all racial identities besides Caucasian in this column as a percentage of the total
population. If there is a significant correlation between race and prescription rate, a future study
should break this variable down into more specific classifications. Data for this control variable
was collected by the United States Census in 2016. I manually calculate the proportions and
Elderly citizens tend to have greater access to prescription opioids and tend to hold
conservative ideologies. The most common off-record method for abusers to obtain prescription
opioids is through elderly relatives and friends. These characteristics suggest that states with
more elderly citizens may have higher opioid prescription rates than states with fewer elderly
citizens do. I account for this alternative by including a column for “percent of population over
the age of 65.” Data for this control variable was collected by the United States Census in 2016.
Methods
relationship between opioid prescription rate and conservative political identity while controlling
for significant external factors. My entire analysis is completed in R Studio using the guidance of
R for Beginners or: How I learned to Stop Worrying and Love R by Kent Freeze and Melanie
Freeze. Packages I use for my analysis are readxl, car, ggplot2, MASS, stargazer, and lmtest. I
use the self-compiled dataset OpioidDataFinal which is described above and available upon
request.
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accomplish this, I create a modified dummy variable. States in which less than 40% of the
population voted for Trump in 2016 are “very liberal.” States in which 40% to 50% of the
population voted for Trump in 2016 are “liberal.” States in which 50% to 60% of the population
voted for Trump in 2016 are “conservative.” States in which greater than 60% of the population
voted for Trump in 2016 are “very conservative.” I then calculate the mean opioid prescription
rate for each of these categories. The outcome is illustrated in a bar plot between Opioid
To test the strength of this relationship for individual cases, I compare the interval values
of the study’s main variables. I accomplish this by running a scatterplot between Opioid
Prescribing Rate 2015 (Y-Axis) and Conservative 2015 (X-Axis). I choose to use the basic plot
function, but a more advanced ggplot2 scatterplot would also be effective. The purpose of this
may have significant influence. To start, I run a multiple regression. Opioid Prescribing Rate
Participation Rate in Economy Total, Age Over 65, Percent non-white, and Population are my
independent variables. I summarize the results of this regression in a Stargazer table and run tests
to interpret the significance of the output. I test the bivariate partial relationship between each
independent variable and Opioid Prescribing Rate 2015 while controlling for all other variables
through an Added Variable Plot. The avPlots function also helps to identify consistent outliers. I
check for outliers and heteroscedasticity by examining a Residual vs. Fitted Values Plot. This is
produced by running the multiple regression through the plot function. I confirm observations of
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heteroscedasticity by completing a Breuch Pagan test through the bptest function. I test for error
term normality by observing a Q-Q plot created using the qqPlot function. Finally, I check for
Results
Overall, there is significant statistical evidence in favor of my hypothesis that states with
more conservative voters tend to prescribe more opioids than states with more liberal voters. The
following bar graph depicts the mean opioid prescription rate for each category of state voter
identity:
This graph shows that there is a clear association between political identity and opioid
prescription rate. Very liberal states have an average opioid prescription rate of 59.3. Liberal
states have an average opioid prescription rate of 72.6. Conservative states have an average
opioid prescription rate of 80.9. Very conservative states have an average opioid prescription rate
of 95.9. This means that very conservative states issue 95.9 prescriptions per 100 people. It is
13
interesting that strength of political identity seems to have an impact. This suggests that political
identity itself may have a larger impact than other associated variables.
It seems that this correlation exists on an individual case basis as well. The following
scatterplot shows the relationship between opioid prescription rate and political identity without
There appears to be an upward sloping linear relationship in this scatterplot. This matches the
theory of my hypothesis. The only exceptions to this trend are outliers in the upper quartile of
percent conservative. The outcome of this scatterplot is promising, because it shows that there is
a fairly strong correlation but still freedom to improve my model with control variables.
After introducing control variables to my model, there is still significant statistical proof
in support of my hypothesis. However, there is also evidence that control variables play valuable
roles in influencing states’ opioid prescription rates. Below is the Stargazer output of the study’s
multiple regression:
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Workforce, and Percent of Population over 65 are each significant within a 95% confidence
level. The adjusted R2 value suggests that this model accounts for 78.1% of variance in opioid
prescription rate. Given how intricate and recently developed the opioid epidemic is, this is an
acceptable value. Race does not appear to be statistically significant, but its existence in
contributing literature and importance to social science support its presence in the model.
There is no significant issue with linearity in this model. In the added variable plot,
Percent Conservative 2015 has a moderately strong positive relationship with Opioid Prescribing
Rate 2015. Population and Participation Rate in the Economy Total have strong negative
relationships with Opioid Prescribing Rate 2015. 2016 Median Household Income and Age Over
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65 have moderately weak negative relationships with Opioid Prescribing Rate 2015. Percent
non-white has a weak negative relationship with Opioid Prescribing Rate 2015. Outliers
consistent to multiple models include Alabama, New Mexico, New York, and Tennessee. It
seems that these outliers may skew the slopes of trend lines but not in a manner significant
Error terms in this model have an adequate normal distribution. Heteroscedasticity does
not appear to be a significant element of this model. In the RVF plot, there does not seem to be
much change in the variance of residuals across the x-axis. The outliers Alabama, New York,
and Tennessee challenge this claim. However, a Breusch-Pagan Test produces a p-value of
.6568. With this value, one is unable to reject the null that there is no heteroscedasticity.
Additionally, the Q-Q Plot shows that error terms seem to match the ideal line of best fit closely
enough to limit the findings of the study. There is a -.65 correlation between Percent
Conservative 2015 and 2016 Median Household Income. This makes sense, because wealth and
economic policy are critical influencers of voters and election outcomes. There is a .54
correlation between Participation Rate in the Economy Total and 2016 Median Household
Income. This also makes sense, because people who are employed always have household
incomes. Other correlations are not significant. In each of these cases, the model would be more
statistically accurate if median household income were removed from the model. However, this
variable adds the element of socioeconomic class that is an essential category of society. I
believe that the inclusion of this variable is important even if it does limit the effectiveness of my
16
model slightly. Therefore, the statistical quality of this model is well-founded enough to support
Analysis
propensity to have a high opioid prescription rate. A 1% increase in the number of conservative
voters in a state predicts a .487% increase in opioid prescription rate. This is a substantively
significant value due to the high population of each state. For example, .487% of California’s
39.25-million-person population is 189,930. One prescription can kill, so having nearly 200,000
approximately 1.3 percent between elections, some states experience a surge in conservative
voters over 10 percent. Although not all of these voters adamantly support opioid prescribing,
this serves to show what could happen if conservative opioid-supporters were to flock together as
liberal drug policies are passed in swing states. Direct government intervention will only
empower many conservative individuals to prescribe out of protest. This will put more opioid
prescriptions on the streets and further contribute to climbing abuse rates. It is not possible to
classify opioids as illegal drugs, because many individuals do rely on them for medical purposes.
Recognizing this, policymakers must work to educate conservative populations on the dangers of
Information gained from the control variables in this study is also useful for isolating
.616% decrease in a state’s opioid prescription rate. This suggests that wealthy individuals
understand the risk of opioid prescriptions better than poor individuals do. A 1% increase in
Participation Rate in the Workforce predicts a 2.776% decrease in a state’s opioid prescription
17
rate. This is a substantial impact for a variable which is fairly easy to monitor and control. A 1%
increase in population over the age of 65 predicts a 2.734% decrease in a state’s opioid
prescription rate. This significant outcome contrasts with the findings of literature on other forms
of prescription drug abuse. Perhaps elderly folks living in assisted care have responsible
individuals administering their prescriptions. Alternatively, states with fewer elderly folks may
corporations. Or maybe the new generation is sociologically more interested in feeling the
impact of drugs including opioid prescriptions. Either way, it is clear that having an older
population decreases a state’s prescription rate. State population is not a substantively significant
variable. Even if it were, it would be very difficult to control overall population growth or the
movement of people between states without violating the constitution. Race is neither a
The findings of this study can be used to develop specific policies and education
curriculums which are effective for high-risk individuals. Ideally, everyone in the nation could
receive the educational benefits and experiences of wealthy individuals, but this is not a
have an increased focus on the dangers of prescribing or requesting opioids. This will help to
ensure that future generations will consider opioids as dangerous as more popularized drugs like
target low-income members of society and those who are not actively pursuing work. Great
locations for these advertisements include community centers, bus stops, billboards, public soup
kitchens, and churches. These locations are accessible to all and particularly those who have
focus on increasing the participation rate in the economy for each state. This can be
social welfare recipients to ensure they are not abusing the system, and working to create job
opportunities through economic policies. The existing political climate will challenge these
potential policy changes, so both sides of the political spectrum will need to sacrifice for the
greater good of society. State policies would be more effective than national policies, because
voters feel as though they have more power at the state level. There are countless other policy
initiatives possible, and this study provides a foundation for these policies to build from.
Conclusion
voter identity positively impacts opioid prescription rates. Other factors, including household
income, participation rate in the economy, and age of population, also contribute significantly. It
is still unclear which factors directly contribute to variation in abuse and overdose rates between
states. Scholars may be puzzled by this question for decades to come. However, this study’s
approach of focusing on opioid prescriptions helps to fill this gap enough for targeted policies to
drug abuse, implementing inclusive opioid drug abuse advertisement campaigns, and focusing on
creating job opportunities to keep potential abusers occupied. More advanced scholars and
politicians may have better insights on the specific policies which match the findings of this
study. I recommend indirect intervention, because current abusers will transition to heroin abuse
I recognize that there are some minor limitations to my study. To start, as a cross-state
study, there is naturally a problem with IID. It is very easy for policymakers, doctors, and
19
abusers to base their behavior off of policies in other states. Additionally, drug abusers can easily
move opioids across state lines once they are prescribed. Fortunately, the independent variables
in this model are not severely impacted by this discordance. By focusing on the prescriber side of
this epidemic, I remove the possibility for interstate transactions. Additionally, individuals are
not able to change their income, age, or identity with ease. Therefore, like other diagnostic
problems mentioned in the methods section, this issue with IID is inconsequential. Additionally,
I base many individual decisions off of statewide or national trends. The largest example of this
is my assumptions about election voters. I identify individuals who voted for Donald Trump with
conservative ideologies. The rest of my study is built off of this assumption. Particularly in the
past year, it has become clear that many true conservative voters do not support the president’s
policies. His drug policy is fairly standard, but Trump’s selection in the primary may have
caused disproportional voter turnout. In the future, with more time, I would use survey data
specific to party identity and drug-policy stance to frame my analysis. Furthermore, there is a
severe time disparity between some of my sources, and this limits the number of samples
available. I only use data from one year for each of my variables. I think that my results may
have been more precise if I used cases from several years. This is difficult though, because there
is no clear start or end date for the opioid epidemic. Perhaps taking median or means of data
The results of this study are accurate but incomplete. This is largely due to the limited 10-
week period of the course. With more time and resources, I would take several additional steps.
First, I would experiment with alternative measures and datasets for each of my variables.
Second, I would conduct interviews to incorporate a qualitative aspect into my analysis. Third, I
backgrounds respond to suggested policy changes. Fourth, I would expand the extent of my
study to the county level. Finally, I would collect individual data on voter preferences, chronic
pain status, and prescription drug use. I would use this data to explore the relationship between
prescription rates and drug abuse more acutely. For now, my study provides an interesting
perspective to the field of public health policy focusing on solving the opioid epidemic within
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