Powerful & Green:

The versatile
Chelating Agent
Sodium Gluconate

Gluconates
Outline

1. Why are chelates used in cosmetics and how do they work?

2. Which chelants are used in cosmetics?

3. What is Sodium Gluconate (SG)?

4. Powerful trials of SG in PC

5. Use the green advantage!

6. New product launches with SG in PC

7. SG in a nutshell

8. Quality Benefits – JBL vs. China Quality

9. Packaging Info

10. www.JBL4U.com – Jungbunzlauer's e-commerce platform

Gluconates
Why chelates in Cosmetics?

Raw materials, Water Production

e.g. fatty acids Ca2+ Mg2+ equipment
Cu2+ Fe3+
soap & bath, hair care, skin care, fragrances, decorative cosmetics

Degradation
Rancidity of active
ingredients

Discolouration Precipitation

Gluconates
What is a Chelating agent?

• Chelating agent = chelant = chelator = sequestrant

• Chelè (Greek) = claw

• A chelant binds a metal ion M

with 2 or more bonds

• Chelant + metal ion = chelate

• A bound metal ion removed from existing deposits can no longer

form new deposits, catalyse rancidity, discolouration, etc.

• Gluconates = excellent chelating agents

– For iron (III) and copper (II) from pH 4
– For all cations in alkaline and highly alkaline conditions

• Reference chelants: EDTA-2Na, EDTA-4Na, Etidronate-4Na

Gluconates
Attributes of chelants

• Chelating power
– Defines how strong a specific chelant binds a specific metal ion
– Expressed by the stability constant of the chelate (log K)
– High value of log K = strong bonds

Log K Tetrasodium Tetrasodium Sodium

EDTA etidronate gluconate
Fe3+ 25.1 21.6 37.2
Cu2+ 18.8 6.4 36.6

• Chelating capacity
– Measures which
quantity of metal
ion can be bound
by 1g of chelant

Gluconates
Where do they come from?
Bio-
INCI Origin /production
degradable
Chemically synthesised from
EDTA (Di-, Tetrasodium) EDTA
petrochemicals _*
Chemical synthesised from
HEDP Tetrasodium Etidronate
petrochemicals _*
Chemical synthesised from
DTPA Pentasodium Pentetate
petrochemicals _*
From flavour enhancer MSG
GLDA Tetrasodium Glutamate Diacetate with formaldehyde and ;
sodium cyanide
Trisodium ethylenediamine From aminoacid L-aspartic
EDDS
disuccinate acid and petrochemicals ;
SP Sodium Phytate extracted from rice bran ;
Fermentation of glucose
TSC Sodium Citrate
derived from corn ;
Fermentation of glucose
SG Sodium Gluconate
derived from corn ;
Gluconates *Slowly and/or poor biodegradable
Production of Sodium Gluconate

O OH +
O O Na
C
C
H C OH
H C OH
Oxidation HO C H + NaOH
HO C H
H C OH
H C OH
H C OH
H C OH
CH2OH
CH2OH
Glucose Gluconic Acid Sodium Gluconate

Gluconates
Stability studies with SG

• Proven to work as chelants in personal care products

– BMDBM* = standard UVA filter in sun care products
– BMDBM is incompatible with iron => orange-red spots
– Strong chelant needed to prevent this coloration (today: EDTA)
– Sun care lotion stability tests (storage conditions: 3 months at 40°C)

0.2% EDTA 0.2% SG no chelant

Ÿ Jungbunzlauer sodium gluconate works as well as EDTA
Gluconates
*BMDBM = Parsol® 1789 = Butyl methoxydibenzoyl methan
Why choosing JBL gluconates?

• Proven to work as chelants in personal care products!

Jungbunzlauer formula Sodium gluconate content Stability*
Sun care lotion 0.2% OK
Sun care cream 0.2% OK
Bath care 0.2% OK
Shower gel 0.2% OK
Hand cream 0.2% OK
Face cream 0.4% OK

* Storage conditions
– 3 months at 4°C
– 3 months at 20°C
– 3 months at 40°C
– 1 month at 45°C

Gluconates
Why choosing JBL gluconates?

• Safety for human being and environment

EDTA Gluconate
Food approval in only CaNa2EDTA, and yes, SG and GdL:
EU & USA strictly limited dosages - quantum satis and GRAS
ADI 2.5mg/kg bw food additives
- ADI “not specified”
Toxicity moderate acute non-toxic
oral toxicity
Irritation irritating to eyes non-irritating to eyes and skin

Sensitisation some positive non-sensitising

responses in tests
Biodegradability poor excellent

Gluconates
Going Natural

• Quality seals natural cosmetics

EDTA Sodium Gluconate

Not OK OK

Not OK
Derived natural substances

Not OK
OK - approved

+ + + + + => COSMOS-standard

SG = chemically processed agro-ingredient of natural origin

Gluconates
Formular Cards with Sodium Gluconate

Leave-on Rinse-off

Gluconates
Where using JBL gluconates?

• Sodium gluconate as safe and natural chelant in

– Bar and liquid soaps
– Shower products
– Shampoos and conditioners
– Hair colours
– Sun care
– Depilatories
+ natural variants

Ÿ Possible claims: “contains no EDTA”, “free from EDTA”,

“corn derived chelant”

Gluconates
Sodium gluconate in a nutshell

• Outstanding iron and copper chelants

• Non toxic
• Non irritating
• Non sensitising

• Occurring in royal jelly, wine & honey

• Made from renewable non-GM raw materials
• Made by a non-GM microbial fermentation

• Fit for natural cosmetics

Gluconates
Chelants in use in PC products

Tetrasodium Tetrasodium Sodium

EDTA etidronate gluconate
Chemical name Na4 EDTA Na4 HEDP Na gluconate

MW (g/mol) 380 294 218

pH 1% solution approx. 11.5 approx. 11 approx. 7.0

Gluconates
Chelants in use in PC products

INCI name Tetrasodium Tetrasodium Sodium

EDTA etidronate gluconate
Product family aminopoly- phosphonates organic acids
carboxylates
Physical form - solution: 40% - solution: 30%
- solid: 85% - solid: 85% - solid: 100%

Active substance - solution: 31% - solution: 21%

content * - solid: 65% - solid: 60% - solid: 90%

Other forms - disodium - disodium

- acid - acid - gluconolactone**

Gluconates
* Expressed as free acid **Jungbunzlauer: glucono-delta-lactone
 SG vs. EDTA:
Chelating capacity Fe(III) ions
3000 Na gluconate
Na4EDTA
2500
mg Fe3+ / g Na gluconate

2000

1500

1000

500

0
6 7 8 9 10 11 12 13 1% 2% 3% 4% 5% 10%
pH NaOH

Gluconates
 SG vs. EDTA:
Chelating capacity Cu(II) ions

900 Na gluconate
Na4EDTA
750
mg Cu2+ / g Na gluconate

600

450

300

150

0
6 7 8 9 10 11 12 13 1% 2% 3% 4% 5%
pH NaOH
Gluconates
SG vs. EDTA:
Chelating capacity Ca(II) ions

350
Na gluconate

300 Na4EDTA
mg Ca2+ / g chelating agent

250

200

150

100

50

0
6 7 8 9 10 11 12 13 1% 2% 3% 4% 5% 10% 20%
pH NaOH

Gluconates
SG vs. EDTA:
Chelating capacity Mg(II) ions

350
SG
Na4EDTA
300
mg Mg2+ / g Na gluconate

250

200

150

100

50

0
6 7 8 9 10 11 12 13 0.5% 1% 2% 3% 4% 5%
pH NaOH

Gluconates
Where do they come from? (extendet)
Bio-
INCI Origin /production
degradable
(Di-, Tetrasodium) Ethylene diamine Chemically synthesised from
EDTA _*
EDTA tetraacetic acid petrochemicals

1-hydroxyethane 1,1- Chemical synthesised from

HEDP Tetrasodium Etidronate _*
diphosphonic acid petrochemicals

Pentasodium diethylene triamine Chemical synthesised from

DTPA _*
Pentetate pentaacetic acid petrochemicals

L-glutamic acid N,N- From flavour enhancer MSG with

Tetrasodium
GLDA diacetic acid, formaldehyde and sodium ;
Glutamate Diacetate
tetra sodium salt cyanide

Trisodium
S,S'-ethylene From aminoacid L-aspartic acid
EDDS ethylenediamine ;
diaminedisuccinic acid and petrochemicals
disuccinate

SP Sodium Phytate Sodium Phytate extracted from rice bran ;

Fermentation of glucose derived

TSC Sodium Citrate Tri Sodium Citrate ;
from corn

Fermentation of glucose derived

SG Sodium Gluconate Sodium Gluconate ;
from corn

Gluconates *Slowly and/or poor biodegradable