Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
For
Of
Project proponent
M/s. Vasudev Drug Intermediates.
CONTENTS
Chapters
S. No. Particulars Page No.
1 EXECUTIVE SUMMARY 1-4
2 INTRODUCTION OF THE PROJECT 5-7
2.1 IDENTIFICATION OF THE PROJECT AND PROJECT PROPONENT 5
2.1.1 IDENTIFICATION OF THE PROJECT 5
2.1.2 PROJECT PROPONENT 6
2.1.3 NATURE OF THE PROJECT 6
2.1.4 NEED OF PROJECT & DEMAND-SUPPLY GAP 6
2.1.5 IMPORTS VS. INDIGENOUS PRODUCTION 6
2.1.6 EXPORT POSSIBILITY 6
2.1.7 DOMESTIC / EXPORT MARKET 7
3 PROJECT DISCRIPTION 8-19
3.1 TYPE & LOCATION OF PROJECT 8
3.1.1 TYPE 8
3.1.1.1 LOCATION 8
3.2 DETAILS OF ALTERNATIVE SITE 11
3.3 SIZE & MAGNITUDE OF OPERATION 11
3.4 PROJECT DISCRIPTION WITH PROCESS DETAILS 11
3.5 RAW MATERIAL FOR FINISHED PRODUCTS 12
3.6 HAZARDOUS CHEMICAL STORAGE & HANDLING 12
3.7 RESOURCE OPTIMIZATION& AVAILABILITY 12
3.7.1 LAND & BUILDING REQUIREMENT 12
3.7.2 EQUIPMENT 12
3.7.3 POWER REQUIREMENT 13
3.7.4 FUEL REQUIREMENT 13
3.7.5 WATER REQUIREMENT 13
3.7.6 MAN-POWER REQUIREMENT 14
3.8 QUANTITY OF WASTE TO BE GENERATED 15
3.8.1 WASTE WATER GENERATION & MANAGEMENT 16
3.8.2 WASTE WATER CHARACTERISTICS 16
3.8.3 AIR EMISSIONS & CONTROL 16
3.8.3.1 PROCESS EMISSION 16
3.8.3.2 UTILITY EMISSION 17
3.8.3.3 FUGITIVE EMISSION 17
3.8.4 HAZARDOUS/NON-HAZARDOUS. WASTES MANAGEMENT 17
3.8.5 NOISE CONTROL 18
3.9 HEALTH AND SAFETY MEASURES 18
3.10 ENVIRONMENTAL HEALTH & SAFETY CELL 18
3.11 POST PROJECT MONITORING PLAN 19
4 SITE ANALYSIS 20-22
4.1 CONNECTIVITY 20
4.2 LAND FORM, LAND USE & LAND OWNERSHIP 20
4.3 TOPOGRAPHY 20
4.4 SALIENT FEATURES 20
4.5 EXISTING INFRASTRUCTURE 20
4.6 SOIL CLASSIFICATION 20
4.7 CLIMATE & METEROLOGY 21
4.7.1 TEMPERATURE 22
4.7.2 HUMIDITY 22
i
S. No. Particulars Page No.
4.7.3 RAINFALL 22
4.7.4 WIND PATTERN 22
4.8 SOCIAL INFRASTRUCTURE 22
4.8.1 EDUCATIONAL FACILITIES 22
4.8.2 MEDICAL FACILITIES 22
5 PLANNING BRIEF 23-24
5.1 PLANNING CONCEPT 23
5.2 POPULATION PROJECTION 23
5.3 AREA STATEMENT 23
5.4 ASSESMENT OF INFRASTRUCTURE DEMAND (PHYSICAL & 23
SOCIAL)
5.5 AMENITIES/FACILITIES 24
5.5.1 DRINKING WATER FACILITIES 24
5.5.2 POWER SUPPLY FACILITIES 24
5.5.3 COMMUNICATION & BANKING FACILITIES 24
5.5.4 TRANSPORT FACILITIES 24
5.5.5 APPROACH TO VILLAGES 24
6 PROPOSED INFRASTRUCTURE 25-25
6.1 INDUSTRIAL AREA 25
6.2 RESIDENTIAL AREA 25
6.3 GREENBELT 25
6.4 SOCIAL INFRASTRUCTURE 25
6.5 CONNECTIVITY 25
6.6 DRINKING WATER MANAGEMENT 25
6.7 SEWERAGE SYSTEM 25
6.8 INDUSTRIAL WASTE MANAGEMENT 25
6.9 SOLID WASTE MANAGEMENT 25
6.10 POWER REQUIREMENT & SOURCE OF SUPPLY 25
7 REHABILITATION & RESETTLEMENT ( R& R) PLAN 26-26
7.1 POLICY TO BE ADOPTED 26
8 PROJECT SCHEDULE & COST ESTIMATES 27-27
8.1 TIME SCHEDULE OF THE PROJECT 27
8.2 ESTIMATED PROJECT COST 27
9 ANALYSIS OF PROPOSAL 28-28
9.1 FINANCIAL & SOCIAL BENEFITS 28
ii
List of Tables
Table No. Topic Page No.
1.1 PROJECT SUMMARY 1
2.1 LIST OF PRODUCTS 5
2.2 LIST OF DIRECTORS 6
3.1 AREA STATEMENT 11
3.2 LIST OF RAW MATERIALS ---
3.3 DETAILS OF HAZARDOUS CHEMICALS/MATERIALS STORAGE AND 12
HANDLING
3.4 LIST OF EQUIPMENT/MACHINERIES 12
3.5 CATEGORY WISE FRESH WATER REQUIREMENT 14
3.6 MAN-POWER REQUIREMENT 14
3.7 WASTE WATER GENERATION 15
3.8 EXPECTED CHARACTERISTICS OF COMPOSITE WASTE WATER 16
3.9 DETAILS OF UTILITY EMISSIONS 17
3.10 HAZARDOUS AND NON-HAZARDOUS WASTE GENERATION AND ITS 17
MANAGEMENT
3.11 SAFETY DETAILS 18
3.12 ENVIRONMENTAL MONITORING PLAN 19
4.1 SALIENT FEATURES OF THE PROJECT SITE 20
4.2 SUMMARY METEOROLOGICAL DATA AT NEAREST IMD STATION- 21
BHARUCH
5.1 DISTRIBUTION OF POPULATION 23
5.2 AREA STATTEMENT 23
8.1 TOTAL CAPITAL COST PROJECTION 27
8.2 RECURRING COST PROVISION FOR EHS 27
List of Figures
Sr. No. Description Page No.
3.1 LOCATION OF THE PROJECT SITE 9
3.2 SATELLITE IMAGE OF THE PROJECT SITE 10
3.3 SITE LAYOUT PLAN 11
3.4 WATER BALANCE DIAGRAM FOR EXISTING SCENARIO 15
3.5 WATER BALANCE DIAGRAM FOR PROPOSED SCENARIO 16
3.6 ORGANOGRAM OF EHS MANAGEMENT CELL 18
List of Annexures
Sr. No. Description
Annexure 1 Process details
Annexure 2 Land possession documents
Annexure 3 Existing CC&A
Annexure 4 List of raw-materials
iii
Project Pre-feasibility report
CHAPTER – 1
EXECUTIVE SUMMARY
The project is summarized in the below table:
Table1.1: Project Summary
PARTICULARS DETAILS
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PARTICULARS DETAILS
By-Product
1 HBr (30 to 35 %) 26.00 - 26.00
2 NaBr 0.50 - 0.50
3 KBr - 25.50 25.50
4 Spent Acetic acid - 5.50 5.50
LOCATION Plot No. 3103, GIDC Estate, Panoli, Dist. Bharuch.
NAME OF Proposed expansion project for manufacturing of bulk drugs and drugs intermediates.
PROJECT
RESOURCES
Land Existing land: 3000 m2 The existing site is located in GIDC Estate,
Vapi
No additional land will be required for
proposed expansion. Necessary
modifications will be done in the
existing infrastructure.
Water Existing Scenario: Total kl/day The fresh water is/will be supplied by GIDC
Domestic: 0.30 kl/day water supply department.
Industrial:0.50 kl/day
Gardening: 0.30 kl/day
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PARTICULARS DETAILS
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PARTICULARS DETAILS
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CHAPTER – 2
INTRODUCTION OF THE PROJECT
2.1 IDENTIFICATION OF THE PROJECT AND PROJECT PROPONENT
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In addition, the company has secured its market by tying up with Nova International, Prakash Chemical Pvt.
Ltd & M/s. Adroit Pharma, M/s. Rohit Exports who already have an established export market. Hence, there
will be no problem of establishing the market for the proposed products.
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CHAPTER – 3
PROJECT DESCRIPTION
3.1 TYPE & LOCATIONOF THE PROJECT
3.1.1 TYPE
The proposed expansion project involves manufacturing of bulk drugs and drugs intermediates. The proposed
expansion is to be carried out on existing site located in GIDC estate of Panoli. Necessary modifications will
be done in the existing infrastructure.
3.1.1.1 LOCATION
The project site is located in the GIDC notified industrial area of Panoli. The existing site selection was guided
by many factors like infrastructure, availability of land, water sources, fuel transportation and power
availability. Specific site selection criteria are as follows:
Availability of trained and skilled manpower nearby because of the proximity to various industrial areas
and city/town.
The location of the project site is provided in figure 3.1, satellite image of the project site is provided in figure
3.2 and the site layout plan of the project site in figure 3.3. The area statement is provided in table 3.1.
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Project site
(Source: Google.co.in)
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3.7.2 EQUIPMENT
The list of equipment’s required for the proposed expansion project are as follows:
Proposed Scenario:
1 SS (48”) 4 Nos.
2 SS (36”) 3 Nos.
3 MSRL(36”) 2 Nos.
4 MSRL (48”) 2 Nos.
5 Sparkler filter (1’ X 16 Plat) 2 Nos.
6 Steam Ejector (7.5 HP) 2 Nos.
7 Nutch Filter (7 kl) 4 Nos.
8 Scrubbing system (1.5 Ft X 8) 2 Nos.
9 Vacuum Pump (10 HP) 2 Nos.
10 SS Jacketed reactor (3 kl) 6 Nos.
11 SS Jacketed reactor (5 kl) 10 Nos.
12 SS Jacketed reactor (6 kl) 10 Nos.
13 M S Auto cleave (10 kl) 2 Nos.
14 GLR (4 kl) 8 Nos.
15 GLR(2.5 kl) 2 Nos.
16 GLR (0.625 kl) 1 Nos.
17 HVD (0.5 kl) 1 Nos.
18 HVD(1.2 kl) 1 Nos.
Dryer
19 Tray Dryer (196 Tray) 8 Nos.
20 FBD (60 kg) 1 Nos.
21 FBD(30 kg) 1 Nos.
22 Hot air dryer (196 tray) 1 Nos.
Utility
23 Steam Boiler (1 Ton) 1 Nos.
24 High thermo boiler (2 Ton) 1 Nos.
25 Cooling tower(100 TR) 1 Nos.
26 DG set (250 kVA) 1 Nos.
(Source: M/s Vasudev Drug Intermediates.)
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Proposed Scenario:
Phase of project Type of No. of workers
Labour General 1st Shift 2nd Shift 3rd Shift
M F M F M F M F
During Construction Managerial 10 - - - - - - -
Skilled 20 - - - - - - -
Un-skilled 30 - - - - - - -
During operations Managerial 6 - 5 - 5 - 5 -
Skilled - 6 - 6 - 6 -
Un-skilled - 10 - 10 - 10 -
(Source: M/s Vasudev Drug Intermediates.)
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The water balance diagram for existing scenario is provided in figure 3.4 and for proposed scenario is
provided is provided in figure 3.5.
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After proposed expansion there will be emission of HCl, SO2, HBr, and NH3 gas. Adequate Scrubber will be
attached as control equipment.
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CHAPTER – 4
SITE ANALYSIS
4.1 CONNECTIVITY
This proposed expansion project is located at Plot No. 3103, GIDC Estate, Panoli, Dist. Bharuch. The site is
Approx. 1.60 km (E) from National highway. The land and infrastructure is already available. And the raw
material is easily available through the easy transport via road connectivity. The nearest Railway station is
Panoli railway station which is 2.09 km (SW) and Surat Airport is 53 km (SW) from the project site.
4.3 TOPOGRAPHY
The topography of Ankleshwar is relatively flat terrain with series of deeply incised creeks of river. There are
generally levee deposits on the bank of river.
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to moderate salinity associated with very deep moderately well drained calcareous, very fine to fine soils with
moderate erosion.
In the Northern part of the study area near to the river, Fine, mixed (calcareous), hyperthermic Fluventic
Ustochrepts with fine-loamy Udic Ustochrepts are present. This are deep, well drained, calcareous, fine soils
on very gently sloping alluvial plain with slight erosion and slight salinity, associated with very deep,
imperfectly drained, calcareous, fine-loamy soils with slight erosion.
4.7.1 TEMPERATURE
The climate of Bharuch is warm and dry during the summer months but humid and pleasant during the
monsoon months. The south-west monsoon from June to September brings copious rain to the territory. The
winter months are generally pleasant. May is generally the hottest month with the mean daily maximum
temperature recorded at 39oC and mean daily minimum temperature recorded at 22.5oC. January is the
coldest month with the mean daily maximum temperature as 32.1oC and mean daily minimum temperature
observed as 12.6oC.
4.7.2 HUMIDITY
Humidity is usually high during the monsoon months, generally exceeding 86.7 %. Humidity decreases during
the summer months. For rest of the year i.e. the period of October to February, the relative humidity ranges
around 66.7 - 71.5 %.
4.7.3 RAINFALL
About 95% of the annual rainfall is received during the southwest monsoon season i.e. from June to
September, July being the month with highest rainfall. The average annual rainfall observed from the data is
2182.8 mm.
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CHAPTER – 5
PLANNING BRIEF
5.1 PLANNING CONCEPT
The proposed expansion project is located at Plot No. 3103, GIDC Estate, Panoli Dist. Bharuch. The nearest
city is Bharuch which is a big hub for chemical & Pharmaceutical Products and also Ankleshwar itself is a big
industrial center. Major raw materials will be sourced locally.
The region is well planned with all the basic infrastructural facilities like internal roads, water supply,
arrangements for power, streetlights, solid waste disposal sites etc.
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5.5 AMENITIES/FACILITIES
5.5.1 DRINKING WATER FACILITIES
There were no Tap water available in 56 villages as per the Census 2011. 24 villages had Wells, 21 villages
had tanks/pond/lake and 34 had hand pumps. 24 Villages had River/Canal passing. Power supply was also
available in all the villages.
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CHAPTER – 6
PROPOSED INFRASTRUCTURE
6.1 INDUSTRIAL AREA
The total area of the plot is 3000 m2 out of which 33.33m2 is the buildup area.
6.3 GREENBELT
Maximum open land will be allotted for green belt development. If required, experts will also be consulted for
selection of species for the development of the greenbelt. Total greenbelt area is Approx 15.90 % of total plot
area and Approx 51.10% of the total open land area.
6.5 CONNECTIVITY
This proposed expansion project is located at Plot No. 3103, GIDC Estate, Panoli, Dist. Bharuch. The site is
Approx. 1.60 km (E) from National highway. The land and infrastructure is already available. And the raw
material is easily available through the easy transport via road connectivity. The nearest Railway station is
Panoli railway station which is 2.09 km (SW) and Surat Airport is 53 km (SW) from the project site.
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CHAPTER – 7
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CHAPTER – 8
PROJECT SCHEDULE & COST ESTIMATES
8.1 TIME SCHEDULE OF THE PROJECT
The installation/ construction will be started after getting approval for Environmental Clearance and NOC from
authorities.
8.2 ESTIMATED PROJECT COST
Environment Protection has also been considered in planning the cost projection. Green belt development is
also considered. The estimated project cost will be approximately 5.0 Crores.
Table 8.1: Total Capital Cost Projection
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CHAPTER – 9
ANALYSIS OF PROPOSAL
9.1 FINANCIAL & SOCIAL BENEFITS
M/s. Vasudev Drug Intermediates is located at Plot No. 3103, GIDC Estate, Panoli, Dist.: Bharuch.
The project will provide direct employment opportunity to 20 persons and indirect employment to
10 persons. The man-power required for the project will be employed locally from the nearby areas.
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Annexure
Annexure-1 Process details
Existing Product:
PARA NITRO BENZYL BROMIDE
Proposed Products
(1) Pranlukast
STEP 1
INPUT OUTPUT
Raw Material Input kg. Product Output Kg.
Reaction, Distillation & Centrifuge
2-2[2-(3-
Chlorophenyl/ethyl]nicotininit
rile 0.800 THF distilled 3.570
THF 4.000 Toluene distilled 5.350
Magnesium 0.220 Loss (THF) 0.030
N Methyl 4 Chloro Piperidine 0.400 Loss (Toluene) 0.050
HCl 6.000 ML to ETP 12.900
Toluene 6.000 Wet Cake 1.520
Water 6.000 Total 23.420
Total 23.420
STEP 2
INPUT OUTPUT
Raw Material Input kg. Product Output Kg.
Reaction, Distillation &
Dry cake 1.000 Toluene distilled 14.920
Centrifuge
HF 2.680 Loss (toluene) 0.040
BF3 1.200 ML to ETP 22.080
Toluene 16.000 Wet Cake 1.600
KOH 2.200 HCl Gas 0.04
Water 15.600 Total 38.680
Total 38.680
INPUT :
Raw Material Input , Kgs OUTPUT :
2-(2-
Methoxyphenoxy)ethyl
Phthalamideride (CV-3) 3.319 Product Output , Kgs
DNS 11.617 Reaction and Cake to Incineration 1.000
Hydrazine Hydrate 0.820 Centrifuge ML 17.664
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output , Kgs
Water 13.940 Organic layer-I 36.905
ML 17.664 Extraction & Aqueous layer 20.587
Chloroform 24.893 Separation
NaOH 0.996
Total 57.492
Total 57.492
INPUT : OUTPUT
Raw Material Input , Kgs Raw Material Input , Kgs
Organic layer-I & II 44.843 Chloroform distilled 31.972
Distillation
Total 44.843 CV-I 1.890
Losses 10.981
Total 44.843
STEP2:
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output, Kgs
DNS 13.500 DNS distilled 4.000
4-hydroxy-9(H)-
Reaction &
carbazole 2.000 Residue 24.010
Distillation
Epichlorohydrin 9.550 Losses 2.700
NaOH 0.400 Total 30.710
Water 5.260
Total 30.710
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output , Kgs
Residue 24.010 Crystaliztion & Wet cake 1.904
DNS 3.500 Centrifuge ML-1 for recovery 23.205
Total 27.510 Losses 2.401
Total 27.510
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output , Kgs
Wet cake 1.904 Dry cake (CV-2) 1.360
Drying
Total 1.904 Loss on drying 0.544
Total 1.904
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output , Kgs
ML-1 for recovery 23.205 ML -1 Recovery DNS+ Epichlorohydrine di 21.000
Total 23.205 Losses 2.205
Total 23.205
(3) CARVEDILOL
STEP 3 :
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output, Kgs
4-oxyanylmethoxy-9(H)-
IPA distilled
Carbazole(CV-2) 1.360 6.968
2-(2- Reaction &
Methoxyphenoxy)ethyl Distillation
Phthalamideride (CV-1) 1.890 Residue 3.250
IPA 7.460 Losses 0.492
Total 10.710 Total 10.710
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output , Kgs
Residue 3.250 Wet cake 1.904
Crystaliztion &
Toluene 17.190 ML forRecovery 27.026
Centrifuge
Cyclo hexane 5.331 Losses 2.853
Ethyl acetate 6.011 Total 31.783
Total 31.783
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output , Kgs
Wet cake 1.904 Drying Dry cake (CV-3) 1.360
Total 1.904 Loss on drying 0.544
Total 1.904
STEP4 :
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output, Kgs
Carvedilol crude(CV-3
Wet cake to incinerator
Crude) 1.360 Purification and 0.900
Ethyl acetate 19.584 Filtration Filterate 16.727
Charcoal 0.300 Losses 3.917
Hyflo 0.300 Total 21.544
Total 21.544
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output , Kgs
Filterate 16.727 Crystaliztion & Wet cake 1.200
Ethyl acetate 3.672 Centrifuge ML -2 for recovery 18.648
Total 20.399 Losses 0.551
Total 20.399
INPUT :
Raw Material Input , Kgs OUTPUT :
Wet cake 1.200 Drying Product Output , Kgs
Total 1.200 Carvidelo (Dry cake) 1.000
Loss on drying 0.200
Packing in drums Total 1.200
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output , Kgs
ML-1 for recovery 23.205 Toluene distilled 16.500
ML -1 Recovery
Total 23.205 Losses 3.481
Residue to Incinerator * 3.224
Total 23.205
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output , Kgs
ML-3 for recovery 18.648 ML -2 Recovery Ethyl acetate distilled 15.316
Total 18.648 Losses 0.565
Residue to Incinerator * 2.767
Total 18.648
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output , Kgs
ML-2 for recovery 27.026 ML -2 Recovery Toluene Distilled 22.674
Total 27.026 Losses 0.819
Residue to Incinerator * 3.533
Total 27.026
(4) Nebivilol
Step-5 NB5 PREPARATION
INPUT : OUTPUT :
Raw Material Input , Kgs Raw Material Output, Kgs
MDC 50.00 Reaction Losses 10.00
6-Fluoro-3,4-dihydro-2H-1-benzopyran 7.84 ML -1 for Recovery 59.89
Quenching
DMSO 8.43 Spent Cake (ProcessWaste) 7.84
Oxalyl Chloride 1.54 Organic Layer 52.00
&
HCl 1.33
Water (Recycled) 50.00 Layer Separation
Na HCO3 0.59
Sodium Sulphate 1.00
Total 120.73
Total 129.73
Step-6 NB6 PREPARATION
INPUT : OUTPUT :
Raw Material Input , Kgs Raw Material Output, Kgs
NB5 52.00 Water distilled Recycle in next B 200.00
Sodium hydride 1.96 DMSO Recovery 33.00
NB6
TMSI 9.80 Reaction Methanol Recovery 7.38
DMSO 34.56 Work Up TMSI Recovery 9.31
Water ( Recycled) 147.00 & Residue 1.27
HCl 0.67 Washings Losses 0.68
Na HCO3 0.59 Mass 62.44
Sodium Sulphate 7.84
MDC 10.66
Ice 49.00
INPUT : OUTPUT :
Raw Material Input , Kgs Raw Material Output, Kgs
Mass 62.44 Distillation MDC Recovery 55.00
MDC Recovery Losses 2.00
Residue 1.63
Product 3.81
INPUT : OUTPUT :
Raw Material Input , Kgs Raw Material Output, Kgs
NB6 3.81 Organic Layer 25.34
Methanol 18.00 Aq. Layer(ML-1) for Recovery 22.78
Benzyl Amine 0.86 NB7
EA 20.67 Reaction
HCL 1.73
Water (Recycled) 3.05
Total 48.12 Total 48.12
INPUT : OUTPUT :
Raw Material Input , Kgs Drying Raw Material Output, Kgs
Mass 1.13 & Dry Cake 1.00
Milling Losses 0.13
Total 1.13 Total 1.13
INPUT : OUTPUT :
Raw Material Input , Kgs Raw Material Output, Kgs
Methanol Recovery 2.200
ML -3 3.60 IPA Recovery 1.16
Solvent Recovery
Res. To Inc. * 0.14
Losses 0.10
Total 3.60 Total 3.60
(5) Rosuvastatin
7-[4[4-fluorophrnyl)-6-isopropyl-2-9N-
1.34 kg methyl]-N-methylsulfonylamino0pyrimidin-5-
yl)]-(3R,5S)-dihydroxyhept -6-enoic acid
Purification
0.14 Kg A. carbon
16 Water
0.15 Kg for
Carbon
incinration
cake wet
0.14 Kg Hyflo
Filtration
1.43 Water
Centrifuge
Water ML 19 L to ETP
Drying
1.76 drying loss
INPUT : OUTPUT :
Raw Material Batch In put Product Batch In put
CH Base wet cake 1.19 Drying CH base 1
Total 1.19 Loss 0.19
Total 1.19
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output, Kgs
Caustic soda 0.180 Mass 16.783
6 HQ 0.559 HCl Gas to Scrubber 0.130
Sodium sulphate 0.653 Reaction
toluene 0.576
Tetrazole 0.847
TBAB 0.037
Water 14.061
Total 16.913 Total 16.913
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output, Kgs
Mass 16.783 ML TO ETP * 17.925
Water 2.542 Centrifuge Cilastazole 1.400
Total 19.325 Total 19.325
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output, Kgs
MeOH 1.695 Leaching Mass 3.095
Cilastazole 1.400
Total 3.095 Total 3.095
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output, Kgs
MeOH 0.424 ML for Recovery -I 2.169
Mass 3.095 Centrifuge Mass 1.35
Total 3.519 Total 3.519
CL-1
INPUT : OUTPUT :
Raw Material Input , Kgs Raw Material Output, Kgs
MeOH 9.492 distilled methanol 9.200
Hyflo 0.034 Purification Spent Charcol 0.137
Mass 1.350 Mass 1.200
Carbon 0.021 Loss 0.360
Total 10.897 Total 10.897
INPUT : OUTPUT :
Raw Material Input , Kgs Raw Material Output, Kgs
MeOH 0.370 Centrifuge ML for Recovery -II 0.470
Mass 1.200 Mass 1.100
Total 1.570 Total 1.570
INPUT : OUTPUT :
Raw Material Input , Kgs Raw Material Output, Kgs
Mass 1.100 Dryer Loss 0.100
Cilastazole pure 1.000
Total 1.100 Total 1.100
Packing In Drums
INPUT : OUTPUT :
Raw Material Input , Kgs Raw Material Output, Kgs
ML for Recovery-I+II 2.639 Solvent Recovery Recovered Toluene 0.550
Recovered Methanol 1.959
Loss 0.010
Residue to incinerator 0.120
Total 2.639 Total 2.639
(8) CH -HCL
INPUT QTY OUTPUT QTY
Raw Material Kgs/ Lit Product Kgs/ Lit
Ch base W/C 1.4 CH -HCL wet cake 1.540
Methanol 6.98 Methanol ML 7.130
Reaction and CF ML to ETP 0.060
HCL- CP 0.49 Loss 0.140
Total 8.870
Total 8.870
Step2-
OUTPUT :
Raw Material Kgs / Lit Product Kgs / Lit
CCl4 Layer 160.00 Mass 165.00
Desloratadine 1.71 Reaction Loss 0.30
TBAB 0.21
NaoH 0.53
Water 2.85 Total 165.30
Total 165.30
Stage-2
Stage-5
Step 1 VF 1 PREPARATION
In Put Qty Out Put Qty
Raw Material Kgs / Lit Product Kgs / Lit
Sodium Methoxide 1.15 Mass 13.03
Methanol 7.25 Reaction
4- Methoxy Phenyl Acetonitrite 1.15
Cyclohexanone 1.75
Water 1.74
Total 13.03 Total 13.03
Step 2 VF 2 PREPARATION
INPUT : OUTPUT :
Raw Material Kgs / Lit Product Kgs / Lit
Ethyl Acetate
Centrifuge &
Mass 1.99 Recovery 5.34
solvent Recovery
Ethyl Acetate 5.40 Residue to Inc * 0.50
Mass 1.55
Total 7.39 Total 7.39
INPUT : OUTPUT :
Raw Material Kgs / Lit Product Kgs / Lit
Mass 1.55 Drying Losses 0.30
mass 1.25
Total 1.55 Total 1.55
(12) VENLAFAXINE
INPUT : OUTPUT :
Raw Material Kgs / Lit Product Kgs / Lit
Mass 2.58 pH Adjustment Aq. To ETP * 3.69
NaOH 1.46 & Mass 10.35
Water 1.00 Extraction
Ethyl Acetate 9.00
Total 14.04 Total 14.04
VST-1.HCl
In Put Qty Out Put Qty
Kgs / Lit Raw material Material Kgs / Lit
0.080 Delta Glucone 1,5 Reaction CH - 1.000
Lacton Gluconate
0.110 CH - base
0.820 Water Handling loss 0.01
OUTPUT :
Raw Material Kgs / Lit Product Kgs / Lit
Mass 85.43 ML to ETP * 93.15
Water 9.25 Centrifuge Wet Cake 1.53
Total 94.68 Total 94.68
INPUT : OUTPUT :
Raw Material Kgs / Lit Product Kgs / Lit
Mass 3.75 Toluene Rec. 2.42
Centrifuge &
Toluene 0.13 Wet cake 1.46
Solvent Recovery
Residue to Inc. * 0.27
Total 3.88 Total 3.88
INPUT : OUTPUT :
Raw Material Kgs / Lit Product Kgs / Lit
Mass 56.84 ML To ETP * 25.50
Water 25.50 Centrifuge ML -1 for DMSO Recovery 54.45
Wet Cake 2.39
Total 82.34
Total 82.34
INPUT : OUTPUT :
Raw Material Kgs / Lit Product Kgs / Lit
Mass 6.93 Filtration Spent cake to Inc. * 0.16
Hyflow 0.07 Mass 7.70
Ethyl Aceate 0.86
Total 7.86 Total 7.86
N-(2-Tetrahydrofuroyl)
12.43 HCl gas to Scrubber 1.5
piperazine
220.69 Total
Terazocin
Monohydrochloride Di- Mass
1.7 Hydrate 103.2
100 Water Dissolution and
1.5 Carbon Purification Total 103.2
103.2 Total
ML 101.50
103.2 Mass Filtration Cake to Incinarator 1.7
103.2 Total Total 103.2
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output , Kgs
Toluene 19.2 Aqueous layer to ETP 2.750
Tetrazole 4.718 LK-1 Preparation Organic layer 25.700
Imidazole 1.308 HCl Gas to Scrubber 0.250
TBAB 0.040 Total 28.700
KOH 0.555
Water 2.880
Total 28.700
INPUT : OUTPUT :
Raw Material Input , Kgs Water wash Product Output , Kgs
Organic layer 25.700 Aqueous layer to ETP 5.000
Water 4.800 Organic layer 25.500
Total 30.500
Total 30.500
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output , Kgs
Organic layer 25.500 Wet Cake 4.800
Water 7.400 Reaction and ML-1 For Recovery 22.947
Sodium borohydride 0.159 Centrifuge ML to ETP 7.40
Toluene 2.088
Total 35.147 Total 35.147
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output , Kgs
Wet cake 4.800 Drying Dry cake 4.000
Total 4.800 Loss on drying 0.800
Total 4.800
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output , Kgs
ML for Rec 30.274 ML for Recovery Toluene Rec 20.500
Total 30.274 Losses 0.210
Residue to Incin. 9.564
Total 30.274
(18) LOSARTON-K
STEP 2 :
INPUT : OUTPUT:
Raw Material Input , Kgs Product Output , Kgs
MeOH 34.139 Losarton-K Cake for incinerator 0.268
KOH 0.428 Preparation Filterate 35.028
LK-1 3.964 Losses 3.414
Charcoal 0.179 Total 38.710
Total 38.710
Filterate OUTPUT :
INPUT : Product Output,Kgs
Raw Material Input , Kgs MeOH distilled 25.604
Filterate 35.028 Distillation Acetonitrile distilled 1.600
Acetonitrile 2.000 Losses 5.554
Total 37.028 Reaction mass 4.269
Total 37.028
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output, Kgs
Reaction mass 4.269 Centrifuge Wetcake 1.400
Acetonitrile 0.400 ML -2 for Recovery 2.842
Total 4.669 Losses 0.427
Total 4.669
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output , Kgs
Wet cake 1.400 Drying Dry cake 1.000
Total 1.400 Loss on drying 0.400
Total 1.400
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output, Kgs
ML for Rec. 22.947 ML for Recovery Toluene recovered 20.430
Residue to inc. 2.207
Total 22.947 Losses 0.310
Total 22.947
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output, Kgs
ML for Rec. 2.842 ML for Recovery Aceto Nitrile Rec. 2.060
Residue to inc. 0.498
Total 2.842 Losses 0.284
Total 2.842
(19) Glibenclamide
Stage-1 Ester Preparation
In put Qty Out Put Qty
Raw Materals Kgs/Lit Material Kgs/Lit
Butanone 2.185 CO2 Gas 0.189
5-Chlor salicyclic Acid 0.789 Buatanone distillate 1.971
Reaction
K2CO3 1.354 Mass 3.268
Dimethyl sulphate 1.314 Loss 0.214
Total 5.642 Total 5.642
INPUT :
Raw Material Kgs/ Lit OUTPUT :
Wet cake 1.300 1.3 Product Kgs/ Lit
Total 1.300 Dryer Dry cake 1.210
Loss on drying 0.090
Total 1.300
Stage -2 AD Base
STEP4 : PURIFICATION
Step-TL-1 A PREPARATION
INPUT : OUTPUT :
Raw Material Input , Kgs Reaction Product Output, Kgs
Mono Ethyl Glycol 10.26 Mass 12.66
2 cyano 4 methyl Biphenyl 1.87 NH3 Gas to Scrubber 0.16
Potassium hydroxide 0.60
Process water 0.09
Total 12.82 Total 12.82
Step-TL-1 C PREPARATION
INPUT : OUTPUT :
Raw Material Input , Kgs Reaction Product Output, Kgs
MDC 11.58 Mass 14.42
TL 1 B product 1.75 HBr Gas to Scrubber 0.24
1-3 Dibromo 5,5 Dimethyl Hyda 1.15
Azo Bis- Isobutynotrile(Catalyst 0.18
Total 14.66 Total 14.66
Step-TL PREPARATION
INPUT : OUTPUT :
Raw Material Input , Kgs Product Output, Kgs
TL-1 1.33 Mass 33.41
HCl 13.56
Methylene dichloride 3.52 Reaction
Water 15.00
VST-1.HCl
In Put Qty Out Put Qty
Kgs / Lit Raw material Material Kgs / Lit
1.31 L-Valine Recovered methanol 9.40
3 Thionyl Chloride Recovered Toluene + Thionyl Chloride 2.84
Reaction
11.06 Methanol Recovered (Acetone + Toluene Traces) 5.70
1.94 Toluene Loss 1.79
5.9 Acetone SO2 Gas to Scrubber 1.61
23.21 Total Output 1.86
Total 23.21
VST-2
VST-3
VST-4
VALSARTAN Final
Cooling to 0-5
deg C for 1 hr
Wet cake
DCM (68.4 L)
GLR (1 hr)
Bicarbonate
(1.84 kg), Water filtrate
(18.4 L)
L)
Extraction Aqueous layer
(8hrs) twice 24.51 L to ETP
L to ETP
DCM layer in
GLR
Distilled MDC 62 L
CH3CN (11.55 L) Distillation
to recovery
10.98 L
Filtration MLR 17.93 L to Recovery CH3CN
6.95 L Dist.
Residue
220.87Total Input Dry Product
VTD (8 hr)
Methanol (27.47 L)
Stage I (1.52 Kg) SSR, Reflux at 70-75
deg C
KOH (0.987 Kg)
Water (15.26 L) 45.237
52.
Layer Separation
Aq. Layer for
Methanol recovery
6.597 ( 46.9 L)
Methanol– 26.09 L
Acetic acid Neutralization & Cool Residue – 0.82
3.62 L to 0-5 deg C for 1hr Losses – 0.56
10.217 To ETP – 18.93 L
DCM – 7.37 L
VTD drying Residue – 0.3 L
Loss- 0.09 L
Dry product
ATQ crude
1.4 Kg
Loss - 0.607
SSR
Cooling to
0-5 deg C
Recovered Acetonitrile–
1.5
29.76 L
Residue – 0.95 L
Losses – 0.5 L
VTD
ATQ final API
(1 kg)
32.4 Total Input 32.4 Total Output
(26) NATEGLINIDE
MATERIAL BALANCE
Trans-4-isopropyl cyclohexyl
Carboxylic acid (1.2 kg)
53.46
Aq. ML-1for recovery (51.66 kg)
Filtration
1.8
Drying
Drying
In exercise of the power conferred under section-250f the Water (Prevention and
Control of Pollution) Act-1974, under section-21 of the Air (Prevention and Control of Pollution)
Act-19B! and Authorization under rule 3(c) & 5(5) of the Hazardous Waste (Management,
Handling and Trans-boundary Movement) Rule-200S, framed under the E (P) Act-1986.
And whereas Board has received consolidated application dated 24/05/2013 with
inward no. 68077 for the consolidated consent and authorization (CC& A) of this Board under
the provisions / rules of the aforesaid Acts Consent & Authorization is hereby granted as under.
CONSENTANDAUTHORISATION:
(Under the provisions / rules of the aforesaid environmental acts)
To,
M/s. VASUDEVDRUGINTERMEDIATES,
PLOT NO: 3103,
GIDCESTATE,PANOLI,
DlST: BHARUCH.
1. There shall be no generation & discharge of the industrial effluent from the
manufacturing process and other ancillary industrial operations, Hence the unit shall
strictly adhere to zero discharge.
2. The quantity of the domestic waste water (sewage) shall not exceed 250 Lit/Day.
3. The total water consumption for industrial process and other ancillary operations shall
not exceed SODLit/Day and water consumption for domestic purpose shall not exceed
300 Lit/Day as mentioned in form -D submitted consent application under Water Act-
1974.
Pag~ lot 5
4. CONDITIONSUNDERTHEAIRACT:
4.2 The flue gas emission through stack attached to boiler shall conform to the following
standards:
4.3 The process emission through various stacks/vent of Reactors, Process and Vessels shall
conform to the following standards from the manufacturing process as well as any other
ancillary process.
4.4 The concentration of the following parameters in the ambient air within the premises of the
industry shall not exceed the limits specified hereunder:
Page20f5
GUJARAT POLLUTION CONTROL BOARD
" ...
PARYAVARAN BHAVAN
Sector 10-A, Gandhinagar 382010
~ Phone : (079) 23226295
GPCB Fax (079) 23232156
'''oho;/o' gov.in
PERMISSIBLELIMIT(microgram ( ;
PARAMETERS
4.5 The applicant shall operate industrial plant / air pollution control equipment very efficiently
and continuously so that the gaseous emission always conforms to the standards
specified in condition nO.4.2 & 4.4 above.
4.6 The consent to operate the industrial plant shall lapse if at any time the parameters of the
gaseous emission are not within the tolerance limits specified in the condition no. 4.2 & 4.4
above.
4.7 The applicant shall provide portholes, ladder, platform etc at chimney(s) for monitoring the
air emissions and the same shall be open for inspection to/and for use of Board's staff. The
chimney(s) vents attached to various sources of emission shall be designed by numbers
such as S-l, S-2, etc. and these shall be painted/displayed to facilitate identification.
4.8 The Industry shall take adequate measures for control of noise levels from its own sources
within the premises so as to maintain ambient air quality standards in respect of noise to
less than 75dB(a) during day time and70 dB(A)during night time. Daytime is reckoned in
between 6a.m. andIO p.m. and nighttime is reckoned between 10 p.m. and 6 a.m.
5. GENERAL CONDITIONS: -
5.1 Any change in personnel, equipment or working conditions as mentioned in the consents
form/order should immediately be intimated to this Board.
Page30fS
6.4 The authorization shall be in force for a period of Five years from the date of application.
6.5 The authorization is subject to the conditions stated below and such other conditions as
may be specified in the rules from time to time under the Environment (Protection) Act-
1986.
7. TERMS AND CONDITIONS OF AUTHORISATION:
7.1 The applicant shall comply with the provisions of the Environment (Protection) Act - 1986
and the rules made there under.
7.2 The authorization shall be produced for inspection at the request of an officer authorized by
the Gujarat Pollution Control Board.
7.3 The persons authorized shall not rent, lend, sell, and transfer of otherwise transport the
hazardous wastes without obtaining prior permission of the Gujarat Pollution Control Board.
7.5 It is the duty of the authorized person to take prior permission of the Gujarat Pollution
Control Board to close down the facility.
7.6 An application for the renewal of an authorization shall be made as laid down in rule 5 (6)
(iiJ.
7.7 Industry shall have to display the relevant information with regard to hazardous waste as
indicated in the Court's order in W.P. No. 657 of 1995 dated 14t' October 2003.
Page 40£5
I
y GUJARAT POLLUTION CONTROL BOARD
PARYAVARAN BHAVAN
Sector 10-A, Gandhinagar 382010
Phone . (079) 23226295
GPCB
Fax (079) 23232156
website. wwwgpcb.govin
78 Industry shal1 have to display on-line data outside the main f.actory.gate with regard tO an.~
. nature of hazardous chemicals being handled in the plant, mcludmg.waste water an d 31
emission and solid hazardous waste generated within the factory premIses.
7.10 Industry shall submit annual report within 15 days and sub sequently by 31,t January every
year.
(K.~RY)
SR. ENVIRONMENT SCIENTIST
ISSUED TO:
Mis. VASUDEVDRUG INTERMEDIATES,
PLOT NO, 3103,
GIDC ESTATE, PANOLI,
DIST, BUARueU,
Page 50f5
OR
OR
OR
Rupatidine
TBAB 0.21
NaoH 0.53
Sodium Sulphate 0.95
Rupatidine O- Xyline 5.70
Acetone 15.96
Silica gel 1.00
Acivated Carbon 0.12
Acetone 8.30
Methanol 7.68
Fumeric Acid 0.47
Acetone 14.94
Crude 1.41
OR
CH-Base 1.33
Cholrhexidine Acetate
Acetic Acid 0.28
OR
Butanone 2.19
5-Chlor salicyclic Acid 0.79
K2CO3 1.35
Dimethyl sulphate 1.31
EDC 3.14
Dimethyl sulphate 1.31
Ester 0.73
Beta phenyl ethylamine 0.49
Sodium Metal 0.01
Methanol 0.14
EDC 5.41
HCL 0.06
Chlorosulphonic Acid 3.22
Amide Solution 1.93
Glibenclamide
Liquor Ammonia 11.46
EDC 3.61
Sulphonamide 1.30
NaoH 0.15
CHIC 0.49
Ammonia 0.12
Hyflow 0.04
Carbon 0.03
Acetone 10.52
Methanol 23.45
CHIC Salt 1.76
HCI 0.65
Hyflow 0.07
Carbon 0.07
OR
4-Amino, 2-chloro,6,7,dimethoxyl Quinazolin 11.26
N-(2-Tetrahydrofuroyl) piperazine 12.43
Terazosin 2-Methoxy Ethanol 197.00
Terazocin Monohydrochloride Di-Hydrate 1.70
Carbon 1.50
AND
MDC 34.05
DMF 0.84
Thionyl chloride 0.60
Pyridine 1.14
3A2HAcetophenone 0.75
HCl 8.54
Sodium bicarbonate 0.97
Nacl 0.91
Ethyl acetate 4.82
Pranlukast
DMSO 3.11
Sodium Methoxide 1.67
THF 7.76
Tert Ester 0.87
Methanol 34.16
Dimethyl formamide 10.09
Charcoal 0.83
TEA 0.36
Methanolic HCl 1.55
OR
2-2[2-(3-Chlorophenyl/0ethyl]nicotininitrile 0.80
THF 4.00
Magnesium 0.22
N Methyl 4 Chloro Piperidine 0.40
HCl 6.00
Toluene 25.50
HF 2.68
Loratidine
BF3 1.20
KOH 2.20
8 chloro Azatidine 1.00
Ethylchloroformate 0.25
Sodium by carbonate 0.15
Acetonitrile 2.00
Charcoal 0.10
OR
L-Valine 1.31
Thionyl Chloride 3.00
Methanol 11.06
Toluene 1.94
Acetone 5.90
Methyl Cyanobiphenyl 2.33
Dibromodimethyl hydantion
1.72
AIBN 0.23
MDC 9.23
Ethyl Acetate 4.21
VST-02 2.33
VST-01.HCl 1.86
Potassium carbonate 1.17
DMF 13.20
Toluene 18.17
Valsartan
HCl 1.34
VST-03.HCl 2.56
Sodium Bicarbonate 2.44
MDC 16.92
Valeryl Chloride 1.15
Triethylamine 0.97
HCl 1.77
Xylene 8.82
Tributyltinch Chloride 3.90
Sodiumazide 0.78
TBAB 0.05
Sodium Hydroxide 1.03
MDC 8.46
Activated Carbon 0.26
Ethyl Acetate 2.31
Xylene 4.41
OR
Toluene 19.2
Tetrazole 4.7175
Imidazole 1.308214286
TBAB 0.039642857
KOH 0.555
Sodium borohydride 0.158571429
Losarton-K
Toluene 2.088
MeOH 34.13928571
KOH 0.4275
Charcoal 0.178571429
Acetonitrile 2
Reaction mass 4.269214286
Acetonitrile 0.4
OR
Malanonitrile 1.35
Sulfur powder 0.66
Propinaldehyde 1.43
TEA 1.26
DMF 7.83
Toluene 2.37
Toluene 0.13
OL1 1.46
DMSO 5.23
KOH 1.21
OFNB 1.34
IPA 2.39
IPA 0.267
OL2 2.037
olanzapine
HCL 8.52
Sn Cl 2 5.22
DMA 8.71
OL3 1.48
TEA 0.59
Piperazine 2.36
DMSO 2.23
Methanol 12.87
Methanol 1.16
Ethyl Acetate 5.58
Charcoal 0.08
Hyflow 0.07
Ethyl Aceate 0.86
Ethyl Acetate 0.86
OR
Ch base W/C 1.40
Methanol 6.98
CH- HCl
HCL- CP 0.49
Methanol ML 7.13
OR
Methanol 11.04
Na-OH flakes 1.76
Loratadine 1.60
Deslora
hy flow 0.13
Methanol 1.11
HCL CP 0.01
OR
MDC 60.66
6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol
7.84
DMSO 42.99
Oxalyl Chloride 1.54
HCl 1.33
Na HCO3 0.59
Sodium Sulphate 8.84
NB5 52.00
Nebivilol Sodium hydride 1.96
TMSI 9.80
HCl 0.67
Na HCO3 0.59
Methanol 36.05
Benzyl Amine 0.86
HCL 1.73
NB7 3.00
IPA-HCL 1.21
OR
Caustic soda 0.18
6 HQ 0.56
Sodium sulphate 0.65
toluene 0.58
Tetrazole 0.85
Cilastazole TBAB 0.04
MeOH 1.70
Cilastazole 1.40
MeOH 10.29
Hyflo 0.03
Carbon 0.02
OR
Trans-4-isopropyl cyclohexyl Carboxylic acid 1.20
D-phenylalanine 1.22
Acetone 13.44
Triethylamine 0.78
Ethyl chloroformate 0.84
Sodium hydroxide 0.30
NATEGLINIDE
Conc. HCl 1.28
MeOH 7.36
Conc. HCl 0.06
Hexane 16.80
MDC 3.85
Acetone 8.96
OR
OR
Amm.persulfate 6.84
Dichlone 0.92
AgNO3 1.71
CH3CN 29.67
DCM 68.40
Bicarbonate 1.84
ATOVAQUONE
ATOVAQUONE
CH3CN 11.55
Methanol 27.47
KOH 0.99
DCM 7.76
Acetic acid 3.62
CH3CN 28.00
AND
2-(2-Methoxyphenoxy)ethyl Phthalamideride
3.319
(CV-3)
DNS 28.61
Hydrazine Hydrate 0.819793
HCl 2.48925
Ethanol 1.7567467
Chloroform 33.516
NaOH 1.396
4-hydroxy-9(H)- carbazole
2.000
Epichlorohydrin 9.550
Carvidelol
4-oxyanylmethoxy-9(H)-Carbazole(CV-2) 1.36
2-(2-Methoxyphenoxy)ethyl Phthalamideride1.89
(CV-1)
IPA 7.46
Toluene 17.1904
Cyclo hexane 5.3312
Ethyl acetate 6.0112
Carvedilol crude(CV-3 Crude) 1.36
Ethyl acetate 19.584
Charcoal 0.3
Hyflo 0.3
Ethyl acetate 3.672
AND
HMDA 0.35
SodiumDicyanamide 0.53
n-Butanol 5.4
TEA 0.1
CH Base HCL 0.9
NaOH 0.29
PCA HCL 1.04
Butenol 2.48
Methanol 4.39
AND
Delta Glucone 1,5 Lacton 0.08
Cholrhexidine Gluconate
CH - base 0.11