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facts about puberty
gynaecomastia occurs in 50% of boys between 10-
16 years,resolves in 3 years
girls have adult looking breasts in SMR 3&5
SMR 2-5 lasts about 3-5 yeas in both sexes
menarche in SMR 3 or 4 pr within 2years of onset
of puberty
investigate amenorrhea only after 2 years og
completion of puberty
when menses start girls are at 2.5-5cm of adult
height
early puberty =short adult height
girls are TAMER than boys
T=thelarche
A=adrenarche
MER=menarchi
boys "TAP HER"
T=testicular enlargement
A=adrenarche
P=penile enlargement
HER=height
estrogen causes breast enlargement
adrogen causes pubic hair growth
girls with breast development and no pubic
hair=testicular feminization
girls with pubic hairand breast
development=increase androgen and decrease
estrogen
girls with no breast development and no pubic hair
and no menarche=turner syndrome
breast masses in girls are mostly benign
ultrasound is the only test used for evaluation.no
mamography,no excision and biopsy required.
fibrocystic disease:most
common,bilateral,tender...OCP
fibroadenoma:unilateral,refer if persists beyond 3
cycles
in precocious puberty,rule out testicular and
ovarian tumors by palpation,ultrasound and serum
LH and FSH level
premature adrenarche is common in girls and
brought earlier to notice.
CAH more likely than adrenal tumors
premature thelarche:<8years unilateral or
bilateral.growth normal,reassure its benign
delayed puberty is more common in girls
prolactinomas should be in differential of every
patient with delayed puberty
CDGP:bone age <chronological age,bone age =
HT age.
hypogonadotrophic ovarian failure ,consider poor
nutrition or eating disorder
kalman syndrome:all midline
structures,nose,pitting,penis,optic
chiasma,hypogonadotrophic
hypogonadism+anosmia
hypergonadotrophic ovarian failure =turner
syndrome
2 year delay between bone age and chronological
age is normal
familial short stature:birth lenghth normal,bone
age=chronological age ,proportionate HT and wt
if child parents were malnourished,then mid
parental Ht is of no use in familial short stature
short stature+micropenis+hypoglycemic fits=GH
defiency
congenital GH deficiency=wt>Ht+delayed bone
age+short stature(decelarated growth rate)
acquired GH deficiency=normal bone age
if there is one pituitry hormone deficiency search
for others(FLAT PIG)
short+overweight+delayed bone
age+constipation+dry skin=hypothyroidism
CAH:precocious puberty+accelerated
growth+addison like picture
nutritional short stature:bone age=chronological
age,HT<wt,
gynaecomastia+small testis+lomgarms and
legs=klinfelter syndrome
if with supirior sublaxation of lens its marfan
syndrome
arm span > height=marfan syndrome
overweight+tall+advanced bone age=simple
obesity
overweight+short+delayed bone age=endocrine
cause
obesity is risk for SCFE.
if patient is tall ,its not cushing
microcephaly+dysmorphism=chromosomal
abnormality
HC+HT spared+wt falls off=caloric insufficiency
quick drop in weight +no drop in height consider
workup for celiac and other malabsorption
syndrome,renal or metabolic disorder
ht+ wt falling+ hc spared=endocrine cause
primary craniosynostosis=normal benign imaging
secondary craniosyostosis=abnormal brain
imaging
ammanorrhea:rule out pregnancy,anatomic
obstruction and malformation
LH-progesterone,FSH,estrogen,breast
hypothyroidism causes increases prolactin level
14-15+no breast+no menses=work up
16-17 yrs+breast development+no menses=workup
workup means:first Hcg then LH,FSH,TSH,PRL
if signs of androgenization add
testosterone+DHEA
delayed puberty+dec LH+dec FSH+inc
exercise=exercise induced amenorrhea
breast development+no hair growth+no
menses=testicular faminization syndrome
low HR+hypothyroidism+orthostatic
hypotension+no menses=anorexia nervosa
acne+no menses+hirsutism+insulin
resistance+LH:FSH ratio>2= polycystic ovarian
syndrome
mood disorder+somatic component 5days before
menstruation=premenstrual syndrome
dysmenorrhea does not have mood disorder
the younger the patient severe the depression
marijuanna can cause galactorrhea
dont do pap smearin STD and menses because it
will give false +ve result
most common STD is HPV
when using anabolic steroids girls look and sound
like boys and vice versa
prolong QT and ST depression in anorexia
refeeding syndrome: enamel erosion+irregular
menses+hypokalemic hypochromic metabolic
alkalosis+inc amylase with fits,delirium+dec
Mg+dec Po4+rhabdomyolysis
any painless testicular mass is cancer untill proved
otherwise
hydroceles are painless,consider surgery after 1
year
spermatocele are painless and don't change with
position
varicocele are painless
inguinal hernia are painful and changes with
position
cremasteric reflex absent+pain on elevation of
testis is testicular torsion
blue dot sign+painful=torsion of appendicular
testis
dysuria+frequency+fever+no discharge+unilateral
pain=epididymitis
unilateral pain+faver+no discharge+no
discharge+no dysuria=orchitis
orchitis+testicular atrophy=cancer risk
orchitis+bilateral pain=infertility
age<3years+phimosis=balanitis
in TSH normal,no problem with thyroid,best
screen
babies normal at birth because thyroxin crosses the
placenta
inc TSH+ dec T4+painless firm
goiter+antithyroglobulins=hashimotothyroiditis
if thyroxin not started till 4 wks then congenital
delay
thyroid nodules in kids are usualy malignant
radioactive iodine uptake is high in Graves and
low in hashimoto
PTU should not be the first line agent because of
toxicity
hyperactivity+disorganized thinking+trouble
sleeping=hyperthyroidism
neonatal thyrotoxicosis occurs in <10% of babies
of Graves disease mother
inborn error of metabolism symptoms doesnot
occur in immediateneonatal period but symptoms
of graves do
polyuria+short QT=hypercalcemia
BONES+STONES+ABDOMINAL
GROONS+PSYCHIATRIC
MOONS=HYPERPARATHYROIDISM
hypocalcemic seizures donot respond to
benzodiazapines
the most common human renal stones are calcium
oxalate stones
acidosis+ca oxalate crystals in urine=ethylene
glycol poisoning
vit D deficiency risk groups
breast fed with no supplementation of vitD
breast fed with ni exposure to light
malabsorption
antiepileptic drugs
there is no single lab patteren for rickets
normal calcium+low Po4+normal25-OH
vitD3+normal PTH=familial hypophisphatemic
rickets
low calcium+low Po4+inc PTH=severe vit D
deficiency
low ca+normal Po4=healing stage of deficiency
rickets
low ca+inc Po4+low PTH=hypoparathyroidism/
phosphorus overload/ pseudohypoparathyroidism
normal ca +inc Po4=renal disease/GH excess
treat with all 3(vit D,Po4,ca) when dealing with
rickets of prematurity
cushing disease=central cause
cushing syndrome=peripheral cause
cushing is never tall
tall+obese+stretch marks=high caloric intake
patient with addison may have elevated ADHthey
should not be diagnosed as SIADH
vomiting+dec Na+inc K=addison disease
secondary adrenal insufficiencyhas normal K and
Na,has midline defects
maintaince therapy for adrenal insufficiency
doesnot include fludrocortisone
if 17-OH progesterne level raisedbut physical
examination normal,then repeat 17-OH
progesterone
if family hx +ve for CAH,get gene testing done on
fetal cells
boys with CAH often do not present at birth,so
screening is important
late CAH can present with precocious puberty
if parents carrier,oral dexamethasone should be
given until sex of baby is determined,if male stop
tx and if female continue
ambigious genitalia+hypertension+normal
sodium=11 hydroxylase deficiency(non-salt
wasting type)
ambigius
genitalia+hypertension+hypokalemia+metabolic
alkalosis=17-OH deficiency
micropenis: <2cm testes present
hypopitutrism
GH deficiency
kallman syndrome
prader willinsyndrome
maternal aunt sterile then its testicular feminization
no female internal structures present in testicular
feminization
no hair,no menses,normal breasts=testicular
feminization
normal penis/testis+rudimentry uterusand fallopian
tubes=MIH deficiency
ovarian failure is indicated by high FSH,top 2
reasons are turner and autoimmune
klinfelter have low upper to lower segment ratio
and low IQ
HBA1C of 8 in kids is acceptable in paediatrics
>in bad
DKA has pseudohyponatremia
acanthosis nigricans is nit part of definition of
metabolic syndrome
low HDL,high triglycerides+normal
glucose=acanthosis nigricans
central obesity+inc BD+low HDL+high
triglyceride+FBS>100=metabolic syndrome
gestational diabetes is not associated with
congenital abnormality
a baby born to GBS +ve mother should be watched
in hospital for 48 hrs
AFP is raised in conditions causing broken skin
CVS should not be done for neural tube defects
amniocentesis can identify neural tube defects via
raised AFP
Quadraple screen:dec AFP,dec estriol,inc HCG,inc
inhibin
for women trying to concieve 4mg of folic acid,if
not 0.4mg/day
adolescent patient+arthritis+smelly greenish
discharge=gonorrhea
pegged teeth are found in congenital syphilis and
incontinentia pigmenti
consider lyme disease if FTA positive but VDRL
negative
tzank smear is not specific for HSV ,do PCR
treat vaginal adhesions only if causing dysuria
with estrogen ointment
food allergies occur within 2 hes after exposure
abdominal pain may be only sign of anaphylaxis in
food allergies
allergies to eggs ,milk,soya will be outgrown by 5
years of age.
breast milk or hypoallergenic formula may delay
the onsetof eczema
treat milk allergy with casein hydrolysate formula
not soya
protein induced enterocolitis resolves once GI tract
matures
best test for protein enterocolitis is flexible
sigmoidoscopy
protein enterocolitis is bloody and treated with
hydrolysate formula or aminoacid formula
lactose intolerance is a disease of <5 years
hydrogen breath test is for lactose deficiency and
bacterial overgrowth
soya milk is the treatment for lactose intolerance ,it
contains sucrose instead lactose
causes of seizures in TBM
raised ICP
electrolyte imbalance
infarction
febrile convulsion
tuberculoma
vasculitis
SIADH
INH therapy
causes of hemiplegia in TBM
vasculitis
basal exudatesin sylvian fissure entraping MCA
lacunar infarcts in internal capsule
calcification
tuberculoma
edema
MDR TB suspect
a) any patient who fails a category 1 or III treatment
regimen
b) any category II patient who is sputum smear
positive at the end of 4 months of treatment or later
c)confirmed MDR TB cases
any MDR TB suspect who is sputum culture +ve
and whose mycobacterium that is resistant in vitro to
atleast INH and rifampicin with or without anti-TB
drugs
XDR-TB
tb resistant to any fluroquinolones and atleast one
of injectable second line
drugs(kanamycin,amikacin,capreomycin)in addition
to MDR-TB
CATEGROY IV REGIMEN
ethambutol,cycloserine,afloxacin,ethionamide,PZ
A
continuation phase:18months
ethambutol,cyclocyrine,afloxacin,ethionamide,
4 sputum are collected and examined by smear and
culture(30 days apart) from 3rd to 7th month of
therapy and 3 monthly after 9monthsonward till
complition of treatment
if culture in last 3 quarter become positive,it is
followed by monthly cultures in the following 3
months
culture converted:2 consective negative cultures 1
month apart
smear converted:2consective negative smears
atleast 1month apart
Diagnostic critaria for congenital TB:infant must
have tuberculous lesion and atleast 1 of following
lesion in the 1st week of life
a primary hepatic comlx or hepatic caseating
granuloma
tuberculous infection of placenta or maternal
genital tract
exclusion of possibility of post natal transmission
BABY BORN TO MOTHER WITH TB
breast feeding to be cntinued
BCG at birth
if chest X ray normal,then give 6HR
if chestX ray abnormalthen 2HRZ+4HR
congenital TB 2HR+7HR
causes of negative mountoux in TB:
malnutrition,TBM,milliry TB
viral:measels,mumps,chicken pox
immunecompromised:HIV, malignancy,drugs
CRF,young infants,stress due to surgery,burns
Causes of vomiting in TBM
drug induced hepatitis(hepatomegaly and elevated
liver transaminase)
inc ICP secondry to ICP associated with
spasticity,garbled speech,brisk deep tendon
reflexes,and papilledema on fundoscopy
gastritis due to steroids associated with epigastric
pain
metabolic decompensation due to carbonic
anhydrase inhibitor(due to metabolic acidosis)
poor prognostic factor in TBM
age < 2years
malnutrition
HIV
altered sensorium/seizure
residual neurological deficit
inadequate treatment
domplication like hydrocephalus
poor prognostic factors in APM
age <6month
10*6 CFU in CSF
coma
seizure upto 7days
Tuberculous lymphadenitis
posterior triangle
supraclavicular
multiple and bilateral
constitutional symptoms
sinuses and fistula
contact history
chest X ray
mountoux positive
atypical
submandibular
preauricular
solitary,unilateral
PAPILLEDEMA
bilateral
vision normal
pain absent
venous pulsation absent
optic neuritis
unilateral
decreased
pain present
absent???