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by the blood
• Dissolved O2
– Is proportional to the partial pressure
Universidad
UniversidadAutónoma
Autónomade
deGuadalajara,
Guadalajara,A.C.
A.C.©©,,2013
2014,
2015
Oxygen transport
• Oxygen carrying capacity
– Maximum amount of O2 that can be combined
with Hb
• 1gm of pure Hb combine with 1.39 ml O2
• Hb is not 100% pure then:
1 gm of Hb combine with about 1.34 ml O2
P50
PO2 when
50% of
Hemoglobin
is saturated
• Increase in
temperature
• Increase in CO2
• Decrease in pH
• Increase in 2,3-DPG
As the % of HbO2
saturation
decreases, the
CO2 concentration
for a given PCO2
increases
• At the tissues:
– Bicarbonate quickly diffuses from RBCs into the plasma
– Chloride shift – to counterbalance the outrush of
negative bicarbonate ions from the RBCs, chloride ions
(Cl–) move from the plasma into the erythrocytes
Universidad Autónoma de Guadalajara, A.C. © , 2013
Universidad Autónoma de Guadalajara, A.C. © , 2014, 2015
Transport and Exchange of Carbon Dioxide
Tissue level
O2 combined with
SaO2 Hb O2 capacity X 100
Low CO