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By amirhossein heydarian
DEFENITION
The terms anemia of chronic disease or chronic disorders refer to mild to
moderately severe anemias ([Hb] 7-12 g/dl) associated with chronic
infections and inflammatory disorders and some malignancies.
The newer name for this anemia is anemia of inflammation(AI)
AI is characterized by:
Inadequate erythrocyte production
Low serum iron
Low binding capacity (i.e low transferrin)
The erythrocytes usually are normocytic and normochromic
but can be mildly hypochromic and microcytic.
EPIDEMIOLOGY
Cancer
Hematologic including multiple myeloma and lymphoma
Solid tumor including carcinoma
ETIOLOGY
Autoimmune
Rheumatoid arthritis and other rheumatologic disorders
Systemic lupus erythematosus
and connective-tissue diseases
Vasculitis
Sarcoidosis
Inflammatory bowel disease
systemic inflammatory response syndrome
ETIOLOGY
Moderately decreased:
The decreased in transferrin concentration develops more slowly than the
decreas in the iron levels because of the longer half-life of transferrin (8-12 days )
compared to the half-life of iron ( approximately 90 minutes )
Increased serum ferritin