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doi:10.5633/amm.2011.0214
Institute of Pharmacology, Faculty of Medicine, University of chloroform, and 1 in 39 of ether. A melting point
Niš, Serbia1 of diazepam is 131.5 to 134.5 °C. The structural
Institute of Pathophysiology, Faculty of Medicine, University of
Niš, Serbia2 formula is as follows:
Faculty of Medicine, University of Niš, Serbia3
Introduction
76 www.medfak.ni.ac.rs/amm
Acta Medica Medianae 2011, Vol.50(2) Drug interactions with diazepam
77
Drug interactions with diazepam . Zoran Bojanić et al.
References
1. Atack, JR. The benzodiazepine binding site of GABA(A) diazepam and flunitrazepam. Pharmacol Toxicol. 1996;
receptors as a target for the development of novel 78: 117-22. [CrossRef]
anxiolytics. Expert Opin Investig Drugs 2005; 14: 601- 10. Ohnhaus EE, Brockmeyer N, Dylewicz P, Habicht H.
18. [CrossRef] [PubMed] The effect of antipyrine and rifampin on the
2. MacKichan J, Duffner PK, Cohen ME. Adsorption of metabolism of diazepam. Clin Pharmacol Ther 1987;
diazepam to plastic tubing. N Engl J Med 1979; 301: 42: 148-56. [CrossRef] [PubMed]
332-3. [CrossRef] 11. Ochs HR, Greenblatt DJ, Roberts GM, Dengler HJ.
3. Mason NA, Cline S, Hyneck ML, Berardi RR, Ho NF, Diazepam interaction with antituberculosis drugs. Clin
Flynn GL. Factors affecting diazepam infusion: Pharmacol Ther 1981; 29: 671-8. [CrossRef]
solubility, administration-set composition, and flow [PubMed]
rate. Am J Hosp Pharm 1981; 38: 1449-54. [PubMed] 12. Hepner GW, Vesell ES, Lipton A, Harvey HA, Wilkinson
4. Abernethy DR, Greenblatt DJ, Morse DS, Shader RI. GR, Schenker S. Phenytoin intoxication during
Interaction of propoxyphene with diazepam, concurrent diazepam therapy. J Lab Clin Med 1977;
alprazolam and lorazepam. Br J Clin Pharmacol 1985; 90: 440-56. [PubMed]
19: 51-7. [PubMed] 13. Dhillon S, Richens A. Pharmacokinetics of diazepam in
5. Mulley BA, Potter BI, Rye RM, Jakeshita K. Interactions epileptic patients and normal volunteers following
between diazepam and paracetamol. J Clin Pharm intravenous administration. Br J Clin Pharmacol 1981;
1978; 3: 25-35. 12: 841-4. [PubMed]
6. Gamble JA, Gaston JH, Nair SG, Dundee JW. Some 14. Kariks J, Perry SW, Wood D. Serum folic acid and
pharmacological factors influencing the absorption of phenytoin levels in permanently hospitalized epileptic
diazepam following oral administration. Br J Anaesth patients receiving anticonvulsant drug therapy. Med J
1976; 48: 1181-5. [CrossRef] [PubMed] Aust 1971; 2: 368-71. [PubMed]
7. Nair SG, Gamble JA, Dundee JW, Howard PJ. The 15. Rogers HJ, Haslam RA, Longstreth J, Lietman
influence of three antacids on the absorption and PS.Phenytoin intoxication during concurrent diazepam
clinical action of oral diazepam. Br J Anaesth 1976; 48: therapy. J Neurol Neurosurg Psychiatry 1977; 40: 890-
1175-80. [CrossRef] [PubMed] 5. [CrossRef] [PubMed]
8. Wijnands WJ, Trooster JF, Teunissen PC, Cats HA, Vree 16. Murphy A, Wilbur K. Phenytoin-diazepam interaction.
TB. Ciprofloxacin does not impair the elimination of Ann Pharmacother 2003; 37: 659-63. [CrossRef]
diazepam in humans. Drug Metab Dispos 1990; 18: [PubMed]
954-7. [PubMed] 17. Siris JH, Pippenger CE, Werner WL, Masland RL.
9. Luurila H, Olkkola KT, Neuvonen PJ. Interaction Anticonvulsant drug-serum levels in psychiatric
between erythromycin and the benzodiazepines patients with seizure disorders. Effects of certain
80
Acta Medica Medianae 2011, Vol.50(2) Drug interactions with diazepam
psychotropic drugs. N Y State J Med 1974; 74: 1554- subjects prior to and following levodopa administra
6. [PubMed] tion. Clin Pharmacol Ther 1971; 12: 397-406. [PubMed]
18. Houghton GW, Richens A. The effect of benzo 36. Jensen JC, Gugler R. Interaction between metro
diazepines and pheneturide on phenytoin metabolism nidazole and drugs eliminated by oxidative
in man. Br. J. Clin. Pharmacol 1974; 1: P344-P345. metabolism. Clin Pharmacol Ther 1985; 37: 407-10.
19. Dhillon S, Richens A. Valproic acid and diazepam [CrossRef]
interaction in vivo. Br J Clin Pharmacol 1982; 13: 553- 37. Abernethy DR, Greenblatt DJ, Divoll M, Arendt R, Ochs
60. [PubMed] HR, Shader RI. Impairment of diazepam metabolism
20. Routledge PA, Kitchell BB, Bjornsson TD, Skinner T, by low-dose estrogen-containing oral-contraceptive
Linnoila M, Shand DG. Diazepam and N-desmethyl steroids. N Engl J Med 1982; 306: 791-2. [CrossRef]
[PubMed]
diazepam redistribution after heparin. Clin Pharmacol
38. Somos P. Interaction between certain psychopharmaca
Ther 1980; 27: 528-32. [CrossRef] [PubMed]
and low-dose oral contraceptives. Ther Hung 1990;
21. Orme M, Breckenridge A, Brooks RV. Interactions of 38: 37-40. [PubMed]
benzodiazepines with warfarin.Br Med J 1972; 3: 611- 39. Ellinwood EH Jr, Easler ME, Linnoila M, Molter DW,
4. [CrossRef] [PubMed] Heatherly DG, Bjornsson TD. Effects of oral
22. Rickels K, Schweizer E, Case WG, DeMartinis N, contraceptives on diazepam-induced psychomotor
Greenblatt DJ, Mandos LA, Garcia España FG. impairment. Clin Pharmacol Ther 1984; 35: 360-6.
Nefazodone in major depression: adjunctive benzo [CrossRef] [PubMed]
diazepine therapy and tolerability. J Clin Psycho 40. Brandstetter RD, Gotz VP, Mar DD, Sachs D.
pharmacol 1998; 18: 145-53. [CrossRef] [PubMed] Exacerbation of diazepam-induced phlebitis by oral
23. Saari TI, Laine K, Bertilsson L, Neuvonen PJ, Olkkola penicillamine. BMJ 1981; 283: 525. [CrossRef] [PubMed]
KT. Voriconazole and fluconazole increase the 41. Lefebvre RA, Flouvat B, Karolac-Tamisier S, Moerman
exposure to oral diazepam. Eur J Clin Pharmacol 2007; E, Van Ganse E. Influence of lansoprazole treatment
63: 941-9. [CrossRef] [PubMed] on diazepam plasma concentrations. Clin Pharmacol
24. Gregoretti SM, Uges DR. Influence of oral atropine or Ther 1992; 52: 458-63. [CrossRef] [PubMed]
hyoscine on the absorption of oral diazepam. Br J 42. Gugler R, Jensen JC. Omeprazole inhibits oxidative
Anaesth 1982; 54: 1231-4. [CrossRef] [PubMed] drug metabolism. Studies with diazepam and
25. Hawksworth G, Betts T, Crowe A, Knight R, Nyemitei- phenytoin in vivo and 7-ethoxycoumarin in vitro.
Addo I, Parry K, Petrie JC, Raffle A, Parsons A. Gastroenterology 1985; 89: 1235-41. [PubMed]
Diazepam/beta-adrenoceptor antagonist interactions. 43. Andersson T, Cederberg C, Edvardsson G, Heggelund
Br J Clin Pharmacol 1984; 17 Suppl 1: 69S-76S. A, Lundborg P. Effect of omeprazole treatment on
[PubMed] diazepam plasma levels in slow versus normal rapid
26. Etoh A, Kohno K. Studies on the drug interaction of metabolizers of omeprazole. Clin Pharmacol Ther
diltiazem. IV. Relationship between first pass 1990; 47: 79-85. [CrossRef] [PubMed]
metabolism of various drugs and the absorption 44. Gugler R, Hartmann M, Rudi J, Brod I, Huber R,
enhancing effect of diltiazem. Yakugaku Zasshi 1983; Steinijans VW, et al. Lack of pantoprazole drug
103: 581-8. [PubMed] interactions in man. Br J Clin Pharmacol 1996; 42:
27. Meyer BH, Müller FO, Hundt HK, Luus HG, de la Rey N, 249-52. [CrossRef] [PubMed]
Röthig HJ. The effects of felodipine on the 45. Merrit GJ, Humphries TJ, Spera AC. Effect of
pharmacokinetics of diazepam. Int J Clin Pharmacol rabeprazole sodium on the pharmacokinetics of
Ther Toxicol. 1992; 30: 117-21. [PubMed] diazepam in healthy male volunteers. Pharmacol Res
28. Heine PR, Weyer G, Breuel HP, Mück W, Schmage N, 1997; 14: S556. [CrossRef] [PubMed]
Kuhlmann J. Lack of interaction between diazepam 46. Boston Collaborative Drug Surveillance Program,
and nimodipine during chronic oral administration to Boston University Medical Center. Clinical depression
of the central nervous system due to diazepam and
healthy elderly subjects. Br J Clin Pharmacol 1994; 38:
chlordiazepoxide in relation to cigarette smoking and
39-43. [PubMed]
age. N Engl J Med 1973; 288: 277-80. [CrossRef]
29. Ozdemir M, Aktan Y, Boydag BS, Cingi MI, Musmul A.
47. Ochs HR, Greenblatt DJ, Knüchel M. Kinetics of
Interaction between grapefruit juice and diazepam in
diazepam, midazolam, and lorazepam in cigarette
humans. Eur J Drug Metab Pharmacokinet 1998; 23:
smokers. Chest 1985; 87: 223-6. [CrossRef] [PubMed]
55-9. [CrossRef]
48. Kleindienst G, Usinger P. Diazepam sedation is not
30. Greenblatt DJ, Abernethy DR, Morse DS, Harmatz JS,
antagonised completely by aminophylline. Lancet
Shader RI. Clinical importance of the interaction of
1984; 1: 113. [CrossRef]
diazepam and cimetidine. N Engl J Med 1984; 310: 49. Niemand D, Martinell S, Arvidsson S, Svedmyr N,
1639-43. [CrossRef] [PubMed] Ekström-Jodal B. Aminophylline inhibition of diazepam
31. Locniskar A, Greenblatt DJ, Harmatz JS, Zinny MA, sedation: is adenosine blockade of GABA-receptors the
Shader RI. Interaction of diazepam with famotidine mechanism? Lancet 1984; 1: 463-4. [CrossRef]
and cimetidine, two H2-receptor antagonists. J Clin 50. Høegholm A, Steptoe P, Fogh B, Caldara A, Pedersen
Pharmacol 1986; 26: 299-303. [PubMed] C. Benzodiazepine antagonism by aminophylline. Acta
32. Klotz U, Gottlieb W, Keohane PP, Dammann HG. Anaesthesiol Scand 1989; 33: 164-6. [CrossRef]
Nocturnal doses of ranitidine and nizatidine do not 51. Niemand D, Martinell S, Arvidsson S, Svedmyr N,
affect the disposition of diazepam. J Clin Pharmacol Ekström-Jodal B. Aminophylline inhibition of diazepam
1987; 27: 210-2. [PubMed] sedation: is adenosine blockade of GABA-receptors the
33. Labs RA. Interaction of roxatidine acetate with mechanism? Lancet 1984; 1: 463-4. [CrossRef]
antacids, food and other drugs. Drugs 1988; 35 Suppl 52. Ghoneim MM, Hinrichs JV, Chiang CK, Loke WH.
3: 82-9. [CrossRef] [PubMed] Pharmacokinetic and pharmacodynamic interactions
34. Wodak J, Gilligan BS, Veale JL, Dowty BJ. Review of 12 between caffeine and diazepam. J Clin Psycho
months' treatment with L-dopa in Parkinson's disease, pharmacol. 1986; 6: 75-80. [CrossRef] [PubMed]
with remarks on unusual side effects. Med J Aust 53. Downing RW, Rickels K. Coffee consumption, cigarette
1972; 2: 1277-82. [PubMed] smoking and reporting of drowsiness in anxious
35. Kales A, Ansel RD, Markham CH, Scharf MB, Tan TL. patients treated with benzodiazepines or placebo. Acta
Sleep in patients with Parkinson's disease and normal Psychiatr Scand 1981; 64: 398-408. [CrossRef]
81
Drug interactions with diazepam . Zoran Bojanić et al.
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