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SCIENCE
The idea was greeted skeptically in scientific circles and ignored by funding
agencies. But one outfit with deep pockets, the Bill and Melinda Gates Foundation,
eventually paid attention, hoping the research might help alleviate global poverty.
Now, after several years of work funded by the foundation, the scientists are
reporting a remarkable result.
“We’re here because we want to alleviate poverty,” said Katherine Kahn, the
officer at the Gates Foundation overseeing the grant for the Illinois research. “What
is it the farmers need, and how can we help them get there?”
One of the leaders of the research, Stephen P. Long, a crop scientist who holds
appointments at the University of Illinois at Urbana-Champaign and at Lancaster
University in England, emphasized in an interview that a long road lay ahead before
any results from the work might reach farmers’ fields.
But Dr. Long is also convinced that genetic engineering could ultimately lead to what
he called a “second Green Revolution” that would produce huge gains in food
production, like the original Green Revolution of the 1960s and 1970s, which
transferred advanced agricultural techniques to some developing countries and led
to reductions in world hunger.
The research involves photosynthesis, in which plants use carbon dioxide from
the air and energy from sunlight to form new, energy-rich carbohydrates. These
compounds are, in turn, the basic energy supply for almost all animal cells, including
those of humans. The mathematical description of photosynthesis is sometimes
billed as “the equation that powers the world.”
For a decade, Dr. Long had argued that photosynthesis was not actually very
efficient. In the course of evolution, several experts said, Mother Nature had focused
on the survival and reproduction of plants, not on putting out the maximum amount
of seeds or fruits for humans to come along and pick.
Dr. Long thought crop yields might be improved by certain genetic changes.
Other scientists doubted it would work, but with the Science paper, Dr. Long and his
collaborator — Krishna K. Niyogi, who holds appointments at the University of
California, Berkeley, and the Lawrence Berkeley National Laboratory — have gone a
long way toward proving their point.
Much of the work at the University of Illinois was carried out by two young
researchers from abroad who hold positions in Dr. Long’s laboratory, Johannes
Kromdijk of the Netherlands and Katarzyna Glowacka of Poland.
No one plans to eat tobacco, of course, nor does the Gates Foundation have any
interest in increasing the production of that health-damaging crop. But the
researchers used it because tobacco is a particularly fast and easy plant in which to
try new genetic alterations to see how well they work.
In a recent interview here, Dr. Kromdijk and Dr. Glowacka showed off tiny
tobacco plants incorporating the genetic changes and described their aspirations.
“We hope it translates into food crops in the way we’ve shown in tobacco,” Dr.
Kromdijk said. “Of course, you only know when you actually try it.”
In the initial work, the researchers transferred genes from a common laboratory
plant, known as thale cress or mouse-ear cress, into strains of tobacco. The effect
was not to introduce alien substances, but rather to increase the level of certain
proteins that already existed in tobacco.
When plants receive direct sunlight, they are often getting more energy than
they can use, and they activate a mechanism that helps them shed it as heat — while
slowing carbohydrate production. The genetic changes the researchers introduced
help the plant turn that mechanism off faster once the excessive sunlight ends, so
that the machinery of photosynthesis can get back more quickly to maximal
production of carbohydrates.
It is a bit like a factory worker taking a shorter coffee break before getting back
to the assembly line. But the effect on the overall growth of the tobacco plants was
surprisingly large.
When the scientists grew the newly created plants in fields at the University of
Illinois, they achieved yield increases of 13.5 percent in one strain, 19 percent in a
second and 20 percent in a third, over normal tobacco plants grown for comparison.
Two outside experts not involved in the research both used the word “exciting”
to describe it. But they emphasized that the researchers had not yet proved that the
food supply could be increased.
“How does it look in rice or corn or wheat or sugar beets?” said L. Val Giddings,
a senior fellow at the Information Technology and Innovation Foundation in
Washington and a longtime advocate of gene-altered crops. “You’ve got to get it into
a handful of the important crops before you can show this is real and it’s going to
have a huge impact. We are not there yet.”
Dr. Bruce also noted that, now that the principle has been established, it might
be possible to find plant varieties with the desired traits and introduce the changes
into crops by conventional breeding, rather than by genetic engineering. Dr. Long
and his group agreed this might be possible.
“We’re in a year when commodity prices are very low, and people are saying the
world doesn’t need more food,” Dr. Long said. “But if we don’t do this now, we may
not have it when we really need it.”
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A version of this article appears in print on November 18, 2016, on Page A12 of the New York edition with
the headline: Taking Aim at Hunger, by Altering Plant Genes.