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He is very much the mirror image of Holmes himself: both of them are
geniuses among their breed, are extremely resourceful, are
sophisticated and commit their activities to prevent boredom. However,
whilst Holmes is a detective, Moriarty, in contrast, is a criminal.
Moriarty is the only adversary that Holmes genuinely fears and admires
(Which is also the way Moriarty views Holmes).
Moriarty is the only villain who drives Holmes the closest to fleeing for
his life
He was only introduced at all so that Conan Doyle could move on from
the character of Sherlock Holmes.
The idea of the clash between Holmes and Moriarty throughout 'The
Final Problem' inspires the notion that Sherlock Holmes went down
destroying his true rival. Also, the idea that Holmes went down, ridding
the world of the most dangerous and powerful criminal minds of the age
- and, against all odds and at the cost of his own life, prevailing over the
criminal.
Adaptations
One could argue that the antagonist in "The Great Mouse Detective,"
Ratigan, is loosely based off Moriarty.
In other works
Moriarty was also in the game The Testament of Sherlock Holmes - part
of the Adventures of Sherlock Holmes (game series) - plotting to frame
Sherlock and take over Britain.
In "The League of Extraordinary Gentlemen", a team of literary heroes is
recruited to confront a dangerous villain, who just happens to be
Professor James Moriarty.