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Pathogenesis,
Diagnosis, and
Management of
Severe Pelvic
Inflammatory Disease
and Tuboovarian
Abscess
CATHERINE A. CHAPPELL, MD and
HAROLD C. WIESENFELD, MD, CM
Magee-Womens Hospital of UPMC, University of Pittsburgh,
Pittsburgh, Pennsylvania
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894 Chappell and Wiesenfeld
chronic pelvic pain, infertility, and ectopic with PID approximately one third have
pregnancy. This review will focus on acute 12
TOA. An increase in the prevalence of
and severe cases of PID, including those TOAs among women hospitalized for PID
complicated by TOA. might be related to increasing frequency
and acceptability of outpatient treatment of
PID, thus leading to hospitalization in only
Epidemiology and Risk Factors severe cases of PID and those with
13
The incidence of PID correlates with the TOAs. The risk factors for TOA are
incidence of sexually transmitted diseases, similar to those of PID, including multiple
which increased in the 1970s and peaked in sex partners, age between 15 and 25 years,
1982 with an estimated 1 million cases and and a prior history of PID. Women with
14.2% prevalence of PID treatment among human immunodeficiency virus infection
reproductive-aged women in the United may be more likely to develop TOA com-
3,4 pared with women negative for human
States. However, generally the incidence
14,15
and prevalence of PID is diffi-cult to assess immunodeficiency virus.
because of the lack of report-ing
requirement for PID, high rates of
subclinical PID, increasing rates of out- Pathogenesis
patient management, and inaccuracies in PID is caused by an ascending infection of
diagnosis. lower genital tract organisms from the
Several risk factors for the develop-ment vagina or cervix into the upper tract,
of PID have been identified, while others including the uterus, fallopian tubes, and
remain controversial. PID is highly peritoneal cavity. Up to 75% of cases
associated with younger age of coitarche, occur during the follicular phase of the
multiple sexual partners, nonuse of bar-rier 16
menstrual cycle. Similarly, a high estro-
contraception, and infection with gen environment along with the presence
5
chlamydia or gonorrhea. The Dalkon of cervical ectopy found in adolescence
Shield, an intrauterine device (IUD) that is facilitates the attachment of Chlamydia
no longer available, increased users’ risk of trachomatis and Neisseria gonorrhoeae,
PID by a wicking effect of its multifila- which may contribute to the higher rates of
ment string that allowed microbes to as- PID among young women.
17
cend into the upper genital tract from the
6 TOAs are also caused by an ascending
vagina. Modern IUDs do not seem to infection to the fallopian tube causing
increase the risk of development of PID endothelial damage and edema of the
beyond the risk associated with insertion of infundibulum resulting in tubal blockage.
7,8
the device. Case-controlled studies have The ovary may become involved presum-
shown an association between vagi-nal ably by invasion of organisms through the
9–11 ovulation site. Eventually the separation
douching and PID. Hypothesized
mechanisms for this association have in- between the ovary and fallopian tube is
cluded the introduction of vaginal mi- lost. Necrosis inside this complex mass
crobes into the upper genital tract by the may result in 1 or more abscess cavities
force of the douche fluid or the shift of 12
and an anaerobic growth environment. A
protective microbiological flora. TOA may also form from local spread of
It is unclear why some women with PID infection associated with uncontrolled
develop TOA, whereas the majority of inflammatory disease of the bowel, ap-
women do not. Formation of TOA may be pendicitis, or adnexal surgery. It is impor-
related to prior PID infection, delay in tant to note that TOAs, unlike other types
treatment, or virulence factors of the of abscesses, occur between organs rather
12 than confined inside an organ. The
pathogens. Among hospitalized patients
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Severe Pelvic Inflammatory Disease 895
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896 Chappell and Wiesenfeld
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898 Chappell and Wiesenfeld
purulent debris.
46
McNeeley et al
47 Intrauterine Contraceptive
showed that the combination of ampicillin, Device (IUCD) In Situ
genta-micin, and clindamycin (87.5%) has When PID occurs with an IUCD in place
an improved cure rate as compared with removal of the IUCD is not required.
50–52
clin-damycin and gentamicin alone (47%). However, 1 randomized study showed that
Therefore, for the treatment of TOA, an removal of the IUCD before the initiation
extended-spectrum cephalosporin for the of antibiotic increased the rate of clinical
coverage of Gram-negative organisms 53
(rather than an aminoglycoside) combined recovery. The availability of alternative
with clindamycin or metronidazole is a methods of contraception and IUCD
good option. replacement should be considered in the
decision to remove the IUCD. Women
Guidelines for the treatment of intra- with PID and an IUCD in place should
abdominal infections have recommended have close clinical follow-up. When the
that when resistance for a specific anti- IUCD is removed, it should not be
biotic exceeds >10% to 20% of all iso- replaced until 3 months after the PID has
lates, then a change in the recommended resolved.
antibiotic should occur. For this reason,
ampicillin-sulbactam is no longer recom-
mended for treatment of community-
acquired intra-abdominal infections be- Surgical Management and
cause of significant increased resistance in
48
Drainage of TOAs
E. coli. As mentioned above, targeted In general, the decision to combine anti-
anaerobic antimicrobial therapy should be microbial therapy with drainage or surgi-
used in women with a TOA. Clindamy-cin cal excision of the TOA depends on the
is generally recommended because this status of the patient and the size of the
was the agent used in the prior studies and abscess. Antibiotics should be initiated as
the agent in which clinicians have the most soon as the diagnosis of TOA is deter-
experience. Although resistance to clinda- mined. When rupture of a TOA is sus-
mycin has been observed in isolates recov- pected prompt surgical intervention is
ered from the lower genital tract in women required because of the morbidity and
49 mortality associated with a ruptured
with vaginitis, the significance of these
54
finding in women with TOA is uncertain as TOA. Signs of sepsis, such as hypoten-
there are no data suggesting higher failure sion, tachycardia, and tachypnea, and an
rates with clindamycin-based regimens. acute abdomen are indicative of rupture,
Antibiotic therapy can be switched from and such patients should immediately
parenteral to oral route of admin-istration proceed to the operating room for surgi-cal
after 24 hours of clinical im-provement, exploration.
resolution of nausea and vomiting and TOAs usually present without evidence
severe pain. Patients should complete an of rupture and in these cases the role for
entire 14-day course of anti-biotics with drainage or operative management of TOA
oral doxycycline. When a TOA is present is less clear. Large case series have shown
or when the illness was preceded by that antimicrobial therapy alone is usually
12,24,36,55,56
gynecologic procedure great-er anaerobic effective in 70% of all TOAs
coverage is required, thus we recommend and in a few of these studies abscess size
the addition of clindamycin or has been shown to be predictive of
metronidazole to doxycycline. We pre-fer treatment success with anti-biotics alone.
45
to use metronidazole because of the Reed et al in 1991 showed that 35% of
increased risk of Clostridium difficile col- abscesses 7 to 9 cm in size required
itis with clindamycin. surgery as compared to almost
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Severe Pelvic Inflammatory Disease 899
57 24
60% of abscesses >9 cm. DeWitt et al of rupture. Options for approach can
showed that abscesses >8 cm more often range from imaging-guided drainage to
required drainage or surgery and were laparoscopy to laparotomy. Most gynecol-
associated with longer length of hospital- ogists continue to use the laparotomy as
ization. Thus, it is reasonable to initiate the preferred surgical approach for de-
antibiotics alone in women who are bridement of TOA. However, the laparo-
hemodynamically stable and when the scopic approach seems to be safe in cases
abscess is 8 cm or less in diameter. When where there is no evidence of TOA rupture
clinical response is not achieved within 48 and may have improved outcomes of lap-
hours after initiation of antibiotics, then arotomy, including decreased length of
surgical management or drainage should hospitalization, decreased rates of wound
be considered. In addition, in women with infections, and more rapid rate of fever
an abscess 8 cm or greater immediate 62
defervesce. However, the surgical ap-
drainage rather awaiting clinical response proach should depend on the skill and
may decrease duration of hospitalization. comfort of the surgeon. Surgeries for TOAs
In addition, aggressive surgical manage- can be very complicated because of the
ment should be considered in postmeno- extensive adhesions from the abscess to the
pausal women, because malignancy is a
surround structures and the necrotic and
concern in any postmenopausal woman
58–60 inflamed tissues surrounding the ab-scess.
who presents with an abscess. Proto- For this reason, the laparoscopic
59
papas et al reported that 8 of 17 (47%) experience and expertise of the surgeon
postmenopausal women had an underly- cannot be understated. We recommend the
ing malignancy as compared with 1 of 76 removal of the abscess cavity and the
premenopausal women (1.3%). Thus, associated necrotic tissue and then irriga-
postmenopausal women with TOA should tion of the peritoneum. We offer hysterec-
be counseled on their risk of malignancy tomy with bilateral salpingo-opherectomy
and potential need for complete surgical to patients who are acutely ill and have
staging. Although the diagnostic yield completed child bearing. This approach
could be lower in these cases due to the may hasten recovery compared with fertil-
significant necrosis of the tissue, a frozen ity-sparing surgery. In addition, this elim-
section of the abscess should be sent from inates the need for repeat surgery that is
the operating room. required in 10% to 20% of women who
24,55
Surgical management options for TOAs have more conservative approaches.
range from only drainage to unilateral Since the 1970s, several imaging mo-
salpingo-operectomy to total abdominal dalities and approaches have been used to
hysterectomy and bilateral salpingo-oo- successfully drain intra-abdominal ab-scess
pherecectomy. Historically, most women collections eliminating the need for
with TOA were managed aggressively with surgery.
12,63,64
Pelvic abscess have been
a total abdominal hysterectomy and bilat- drained using ultrasound or CT guidance
eral salpingo-opherectomy. Although this with a transabdominal, trangluteal, trans-
approach offered high cure rates, it was at rectal, or transvaginal approach. The ap-
the cost of high rates of surgical com- proach depends on the location of the
plications, infertility, and hormone defi- collection, with most commonly a trans-
61
ciency. With the advent of effective abdominal approach for abscesses in the
antimicrobial therapy, operative manage- upper pelvis or abdomen and a transva-
ment has become much more conservative ginal approach for deeper pelvic ab-
65
moving toward procedures that allow for scesses. Abscesses can be drained with a
sparing of ovarian function and if possible catheter placement or aspiration alone with
can even be considered in cases a success rate ranging between
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900 Chappell and Wiesenfeld
66 women had a recurrence within 84
77.8% and 100%. In a prospective
68
randomized trial comparing treatment of months. Westrom and colleagues fol-
TOA with antibiotics alone or antibiotics lowed a cohort of 415 women with visu-
with aspiration of the abscess, 17 of 20 ally confirmed PID and found that on
women responded in the aspiration group, average 21% of the women had infertility.
whereas only 10 of 20 responded in the The most important predictor of infertil-ity
antibiotics alone group. In addi-tion, time was reinfection: 12.8% with a single
to discharge was much shorter in the episode, 35.5% with 2 episodes, and 75%
aspiration group when compared with the with Z3 episodes. In addition, they noted
antibiotics alone group, 3.9 ver-sus 9.1 that the severity of the initial PID case was
days, respectively.
67
Gjelland and a predictor of fertility outcome; with in-
fertility rates of 2.6%, 13.1%, and 28.6%
colleagues reported a cohort of 302 wom-
for mild, moderate, and severe disease,
en with TOAs treated with antibiotics 17
combined with ultrasound-guided trans- respectively. Chlamydial infection and
vaginal aspiration of the abscess with a delay in seeking care are also known risk
success rate of 93.4%. They repeated the factors for infertility in women with
69,70
aspiration if abscess material was still seen PID. The incidence of ectopic preg-
on ultrasound 2 to 4 days after initial nancy in the first pregnancy after PID was
aspiration. They reported complete pain 7.8% as compared with 1.3% of women
relief in 62.3% of the women within 48 71
without a history of PID. In addition to
hours of the first aspiration and no pro- complications related to pregnancy out-
cedure-related complications. Only 6% of comes, the scarring and adhesions caused
this cohort of women ultimately re-quired by PID may also lead to chronic pelvic
32
surgery. The optimal approach for pain in women with a prior history of PID.
management of TOA is still debatable. Up to one third of women with a history of
However, in institutions where there are PID go on to develop chronic pelvic
37,72
radiologists trained to do these proce- pain. Similar to the risks of infertility,
dures, it seems advantageous to consider the number of PID recurrences was the
transvaginal aspiration of the abscess in strongest predictor for the devel-opment of
combination with standard antibiotics, 73
chronic pelvic pain.
particularly with larger abscesses, as this
may increase the response rate, decrease
the length of hospitalization, and improve Conclusions
pain control. Severe PID and PID associated with TOA
contribute significantly to the number of
patients with pelvic infections admitted to
Long-term Complications the hospital. These diagnoses are associ-
Although prompt diagnosis and treat-ment ated with significant long-term morbidity,
decreases the risk of long-term com- including poor reproductive outcomes and
plications of PID, many women, despite chronic pain. A high level of suspicion for
adequate treatment, still suffer from re- TOAs in women with PID is required, as
current PID, infertility, ectopic preg-nancy, many women with TOAs do not have fever
and chronic pelvic pain. These or an elevated white cell count. Women
complications are attributable to scarring with TOAs should be admitted to the
and adhesion formation that accompany hospital and immediately started in IV
the healing of tissues that were damaged antibiotics that cover enteric Gram-
initially at the time of acute infection. One negative rods (a virulent cause of sepsis)
study reported that 15% of women had a and anaerobic bacteria (especially in the
recurrence within 35 months and 21% of cases of TOAs). Percutaneous
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