Sept. 26,1952 A New Sioermesis of Chronogesne ass Ionrmmonos mu ot Lanonsronr ov nsw Camuarn® oF RF LSECERSEY oF Wises) A New Synthesis of Chloroquine By Wass 8. Joussox asp Bowers 6. Bost Reenens Nato 16 ‘Se service ented an 1) bac chen by anew when, Te nt (¥ or aon: sd a a oh int ara ye on Sea ieee ee 2s ree maene aete tecie laa Se eee goccmcoserae [bos sobre Neecere remeees w/AG teenies = ° HNC ucaycaycustcaoy A) cmcoon sem AA, oy oy ary ! io 1, mento rl ge sy Berne ert Enid ih Elitintimne Letter, ESR Sa tae eee oo area ere ii, PUT eat Soa irs ances ne emg Ioeh eae eee SLOP RSs hang hs = (A) gxco0cs ok, Acones of oe hn ee vseeo0est Ao In view of the more speci orientation inthe ‘sion of the asd VF peepred by topiation of Gedo Ve seeloealine aad meio ery late, flowed by hydrolyse exter to eve Chive de deliced Tetra omer forma Vi {sp in place of HY in over 50 ye we cna cea esrb to ues he ashy ‘STSCI iat chlorine’ iy with the ge ef frovidng at" inproved wratie A deco faach sy Fepored hee is minima ork ne Bop te impo she rao of Vl te Tanke ibis Qe Hy with a view to eaplonag {Bett etc gman ration pak ‘letslominopertanone-t anogous to the schesie teed by Blderield, Rreyse, Dunn and Hot ‘eyl forthe prepertion of plasmochin. | At Teinpeove oaslyfepeetad® 12 ye ‘hecnine by dekyaretiow of te oxime VEE ‘yeohere- toaniines wasapplie bo keto-.bay tet Fiydroquinaine, fy hetiag the ase wid ‘Gham-ontarbon, cme 4aminoquivtine, Gt = RE = Bh, wae pnduced in 8% ye The prod. ‘ict, however, was dificlt to iy sad aera Sere ra ee ellos ae oe ge meee Sonne ate whe AA AA whe ‘Our atenton was Sally dinected toa suc of she condensation of a-Letotetrshvdrogenmtnes (sack as VI) with primary amines." Te was hoped