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1. Class IV - calcium channel blockers (Ca2+) which drugs are anti arrythmics?
A diltiazem
B esmolol
C Flecainide,
D sotalol,
E Verapamil,
2. Chronic use = high incidence of AE • Reversible lupus-like syndrome (25-30%) • Toxic doses: asystole,
induction of ventricular arrhythmias • CNS effects (depression, hallucination, psychosis) • Weak
anticholingeric effects • Hypotension Describes the adverse effects of what Anti-arrhythmic ?
A Disopyramide
B Procanimide
C Quinidine
3. Class I - fast channel blockers (Na+) : Which drugs are class 1A?
A disopyramide
B Lidocaine,
C procainamide,
D propafenone
E Quinidine,
D Slowing conduction
5. Class I - fast channel blockers (Na+) Which drugs are class 1B?
A disopyramide
B Flecainide,
C Lidocaine,
D mexiletine
E propafenone
6. Class 1 C antiarryhthmics?
A Flecainide
B Lidocaine
C Mexiletine
D Propafenone
E Quinidine
7.Flecainide and propafenone are associated with the potential for fatal ventricular arrhythmias in
persons with ??
B CHF
8. Reduce both heart rate & myocardial contractility ( 1) • Slow conduction of impulses through
myocardial conducting system • Reduce rate of spontaneous depolarization in cells with pacemaker
activity (block of adrenergic release) • Little effect on action potential in most myocardial cells Name
that class of antiarrhythmics/drug class
D Class 2 / B blocker
A (b-blockers)
A Amiodarone,
B diltiazem
C dofetilide
D mexiletine
E sotalol,
A (b-blockers)
A Flecainide
B Lidocaine
C Mexiletine
D Phenobarbital
E Propafenone
A Mild Na Channel block slowing down QRS / Shortened Repol Decreasing QT interval
A marked Na channel block, lengthening the QRS complex dramatically// no change in repol, no change
in QT interval
B Mild Na channel block, lengthening the QRS complex mildly// shortening in Repol decrease in QT
interval
C Moderate Na channel block, lengthening the QRS complex moderatly// shortening in Repol
increaseing QT interval
16. Slow Phase 0 & decrease slope of Phase 4 • Shorten Phase 3 repolarization • Little effect on
depolarization phase of action potential in normal cells • Rapidly associate and dissociate with Na+
channels Describes which class/ drugs of anti-arrhythmics?
A Class 1 A
B Class 1 B
C Class 1 C
D Flecainide/Propafenone
E Lidocaine/ Mexiletine
17. Markedly depress Phase 0 of action potential marked slowing of conduction of action potential
but, little effect on duration or ventricular effective refractory period • Associate and re-associate slowly
with Na+ channels • Show prominent effects even at normal heart rates MOA for which class of
antiarryhthmics?
A Class 1 A
B Class 1 B
C Class 1C
18. Most antiarrhythmics suppress automaticity by blocking either Na + or Ca2+ channels to reduce ratio
of these to K+ to
C Lower the threshold of discharge to less negative voltage --> Decreasing the frequency of discharge
D raise the threshold of discharge to less negative voltage --> Decreasing the frequency of discharge
A (IA)
B (IB)
C (IC)
21. What class/ Drug is used for: Acute treatment of ventricular arrhythmias from myocardial infarction
or cardiac manipulation (eg, cardiac surgery) • Treatment of digitalis-induced arrhythmias
A Class 1 B
B Class 1 C
C Class 1A
D Lidocaine
E Quinidine
22. Concomitant Class III activity (block K+ channels) • Pro-arrhythmic • Due to toxicity is being replaced
by Ca2+ antagonists Clinical Applications • Suppression of supraventricular and ventricular arrhythmias
Replaced by more effective/safer antiarrhythmic agents
A Disopyramide
B Procainamide
C Propanolol
D Quinidine
A Lidocaine
B Mexiletine
25. • Slow rate of change of phase 0 • Slowing conduction, prolonging action potential & increasing
ventricular effective refractory period • Prolong phase 3 by an inhibiting K+ channels • Intermediate
speed of association with activated / inactivated Na+ channels & intermediate rate of dissociation
A Class 1A
B Class 1B
C Class 1C