Neoplasia B.

Rate of growth
1. A malignant epithelial cell neoplasm C. Type and amount of necrosis
derived from any of the three(e) D. Evidence of metastasis
germ layers is referred to as: E. Mode of spread
A. Sarcoma 8. Which one of the following
B. Carcinoma neoplasms is highly invasive but
C. Teratoma seldom spread by metastisis?
D. Mixed cell tumor A. Papillomas of the skin
E. Adenoma B. Squamous cell carcinomas of
2. The study of neoplastic growths is the skin
referred to as: C. Adenocarcinomas of the lungs
A. Tetralogy D. Basal cell carcinomas of the
B. Anaplasia skin
C. Oncology E. Osteogenic sarcomas of the
D. Neoplasia limbs
E. Dysplasia 9. Which one of the following features is
3. A benign epithelial cell neoplasm more characteristic of a benign than
derived from non-glandular surfaces a malignant neoplasm
is referred to as: A. Grows by expansion and
A. Papilloma implantation occurs frequently
B. Sarcoma B. Metastasizes if the brain is the
C. Adenoma site of origin
D. Hamartoma C. Usually non-encapsulated and
E. Squamous cell carcinoma necrosis seldom occurs
4. Which one of the following is not D. Tend to recur after surgical
considered to be a distinctive pattern removal
of non-neoplastic growth? E. Usually occur singly and do
A. Regeneration not recur after surgical
B. Hypertrophy removal
C. Hyperplasia' 10.10. which of the following is least
D. Anaplasia likely to be the primary cause of
E. Metaplasia neoplastic tranformation in animals
5. Each of the following is an anaplastic A. Rna oncogenic viruses
change except: B. Radiation
A. Pleomorphism and C. Chemical carcinogens
hyperchromatism D. Immunologic reactions
B. Increased mitosis and mediated by ige
abnormal mitotic figures E. Dna oncogenic viruses
C. Nuclei that vary in shape and 11.There are at least three (3) groups of
size dna viruses known to have strong
D. Presence of undifferentiated oncogenic potential in animal
cells systems. Which one of the following
E. Presence of abundant is true for dna viruses with the
chromatin in cytoplasmic capability of causing neoplastic
organelles transformation
6. Liver nodules that consist of A. A. dna viruses do not replicate
congenital localized overgrowth of within host cells in which they
mature hepatocytes are referred to induce neoplastic
as: transformation
A. Hepatomas B. B. dna viruses are able to
B. Hamartomas replicate within host cells and
C. Benign sarcomas at the same time induce
D. Nodular hyperplasia neoplastic transformation
E. Bile duct anaplasia C. C. defective dna oncogenic
7. Which of the following is least likely viruses which lack the genetic
to be used as a means of information necessary for
distinguishing a benign from a replication are unable to cause
malignant neoplasm? neoplastic transformation
A. Degree of cellular D. D. dna oncogenic viruses will
differentiation cause neoplastic
 transformation only in cells
derived from animal species
that are the normal host for
the virus
E. E. oncogenic dna viruses
possess the genetic
information for the synthesis
of rna-dependent dna
polymerase which is a
requirement for neoplastic
transformation
F. Answer: A
12.Which one of the following is a
feature of rna retroviruses
A. Rna retroviruses do not
replicate within host cells in
which they induce neoplastic
transformation
B. Rna retroviruses will cause
neoplastic transformation only
within non-permissive cells
derived from species that are
not the normal host of the
viruses
C. Rna retroviruses are able to
replicate within host cells and
at the same time induce
neoplastic transformation
D. Rna retroviruses possess the
genetic information for the
synthesis of reverse
transcriptase which causes
neoplastic transformation
when inserted into the
mitochondria of susceptible
cells
E. When rna retroviruses induce
cellular transformation,
complete virons are not
produced and/or released
13.More than 200 years ago, the London
surgeon sir Percival Pott correctly
attributed scrotal skin cancer in
chimney sweeps to chronic exposure
to soot. Today, many chemical
agents are well-established
carcinogens. which one of the
following is not true for chemical
carcinogens
A. Chemical carcinogens are of
diverse structure and both
synthetic and natural products
are capable of causing
neoplastic transformation
B. There is strong evidence that
carcinogenic chemicals
ultimately exert their effect by
binding to dna to induce a
mutation
C. Chemical carcinogenesis is
dosedependent and the
effects are irreversible
carconogenic effect, but they
augment the action of
cocarcinogens
D. In chemical carcinogenesis,
there is a lag period between
exposure and the appearance
of neoplasms
E. Procarcinogens are chemical
agents which by themselves
have no carcinogenic effect,
but they augment the action
of cocarcinogens
14.Which one of the following is
considered to be the hallmark of
malignancy
A. Anaplasia and the rate of
growth of the neoplastic mass
B. Metastasis and the degree of
encapsulation of the
neoplastic mass
C. Formation of giant cells and
cellular anaplasia within and
around the neoplastic mass
D. Presence of undifferentiated
cells and evidence of
metastasis
E. Cellular anaplasia and growth
by expansion of the neoplastic
mass
15.Metastasis refers to the spread of
neoplastic cells from one part of the
body to another. Which one of the
following is true for metastasic
neoplasms in animals.
A. A. the lungs, heart, and brain
are considered to be the most
common sites for tumor
emboli to lodge
B. B. there is a tendency for
sarcomas to metastasize by
way of lymphatic, whereas
connective tissue neoplasms
tend to metastasize by way of
the bloodstream
C. C. there is a tendency for
connective tissue neoplasms
to metastasize by way of
lymphatic, whereas
carcinomas tend to
metastasize by implantation
D. D. it is more common for
carcinomas to metastasize by
way of lymphatics, whereas
sarcomas tend to metastasize
by way of the bloodstream
with a high degree of
frequency
 E. E. well-differentiated benign
neoplasms are more likely to
metastasize to remote sites in
the body than anaplastic
neoplasms
16.Which of the following is an
appropriate definition of a neoplasm?
A. The term neoplasm refers to a
new growth of tissue in which
the growth rate is similar and
is coordinated with that of
normal tissue; it serves no
useful function, and persists in
the same excessive manner
after cessation of the stimuli
which evoked the change
B. The term neoplasm refers to a
new growth of tissue in which
the growth rate exceeds and is
uncoordinated with that of
normal tissue; it serves no
useful function, and regulatory
mechanisms of cell contact
inhibition, differentiation, and
mitosis are defective; it
persists in the same excessive
manner after cessation of the
stimuli which evoked the
change.
C. The term neoplasm refers to a
controlled new growth of cells
in which regulatory
mechanisms of differentiation
and mitosis are defective, but
cell contact inhibition is
normal; such a growth abates
when the inciting stimulus is
removed and/or destroyed
D. The term neoplasm refers
simply to a swelling of tissue;
however, the term is often
used synonymously with
cancer.
E. The term neoplasia refers to a
new growth of cells that is well
differentiated, is not life
threatening, grows rather
slowly, will not metastasize,
and is amendable to
treatment.
F. Answer: B
17.19. the process of neoplastic cells
moving through the circulatory
system and becoming lodged in a
vessel causing obstruction is referred
to as:
18.A. anaplasia
19.B. neoplasia
20.C. thrombosis
21.D. transplantation
22.E. embolism
23.Answer: E
24.
25.20. age and sex are considered to be
important factors that predispose
animals to neoplasia. which one of
the following is not true for these two
predisposing factors?
26.A. neoplasms are usually more
frequent in older than in younger
animals
27.B. sarcomas are more common in
younger animals than neoplasms
derived from epithelial cells
28.C. in general, the incidence of
neoplasms in the two sexes is
approximately the same; however,
the type of neoplasms vary
29.D. the canine transmissible veneral
tumors are more common in
relatively young dogs during the
years of greatest sexual activity
30.E. neoplasms of the perianal glands
of the dog is more common in the
female than in the male suggesting a
hormonal relationship
31.Answer: E
32.
33.21. the most common method
employed to diagnose neoplasis in
animals is which one of the
following?
34.A. exfoliative cytology
35.B. biopsy technique
36.C. radiographic techniques
37.D. chemical analysis
38.E. fluorescent antibody test
39.Answer: B
40.
41.22. which of the following is the most
common neoplasm of the eye and
related structures of cattle:
A. A. squamous cell carcinoma
B. B. basal cell carcinoma
C. C. adenocarcinoma
D. D. fibrosarcoma
E. E. chemodectoma
F. Answer: A
42.23. a neoplasm composed of a
variety of cell types representing
more than one germ layer is referred
to as:
43.A. papilloma
44.B. carcinoma
45.C. teratoma
46.D. sarcoma
47.E. polyp
48.Answer: C
49.
50.24. the most common neoplasm 96.Answer: D
encountered in cat is: 97.
51.A. mast cell tumors 98.30. the neoplasm least likely to be
52.B. squamous cell carcinoma caused by a viral agent is:
53.C. oral papilloma 99.A. malignant lymphoma of cats
54.D. malignant lymphoma 100. B. cutaneous papillomas of
55.E. teratoma cattle
56.Answer: D 101. C. squamous cell carcinoma
57. 102. D. equine sarcoid
58.25. the most common neoplasm 103. E. transmissible fibrosarcomas
encountered in the myocardium and of cats
abomasum of adult cattle is: 104. Answer: C
59.A. hemangiopericytoma 105.
60.B. rhabdomyoma 106. 31. spirocerca lupi of dogs has
61.C. malignant lymphoma been incriminated as a likely cause
62.D. basal cell carcinoma of:
63.E. adenocarcinoma 107. A. malignant lymphomas and
64.Answer: C rhabdomyomas of the esophagus
65. 108. B. osteogenic sarcomas and
66.26. cutaneous papillomatosis is most fibrosarcomas of the esophagus
common in: 109. C. mast cell tumors and
67.A. canine histocytomas of the esophagus
68.B. porcine 110. D. fibrosarcomas and
69.C. equine adenocarcinomas of the esophagus
70.D. bovine 111. E. squamous cell carcinomas
71.E. feline and osteogenic sarcoma of the
72.Answer: D esophagus
73. 112. Answer: B
74.27. in cattle, which one of the 113.
following neoplasms is more likely to 114. 32. which one of the following
metastasize to orbital sites resulting neoplasms can be transplanted from
in protrusion of the eyeball? animal to animal by whole cells in
75.A. malignant lymphoma the natural state?
76.B. rhabdomyoma 115. A. fibrosarcoma of horses
77.C. leiomyoma 116. B. histocytomas of dogs
78.D. adenocarcinoma 117. C. leiomyoma of cattle
79.E. squamous cell carcinoma 118. D. pheochromatoma of cats
80.Answer: A 119. E. canine veneral tumor
81. 120. Answer: E
82.28. the process by which glandular 121.
epithelium of the prostate is 122. 33. which one of the following
transformed into squamous neoplasms is least likely to be
epithelium following prolonged congenital in origin?
administration of estrogens is known 123. A. embryonal nephromas of
as: pigs
83.A. neoplasia 124. B. basal cell tumors of dogs
84.B. dysplasia 125. C. mesothelioma of cattle
85.C. hyperplasia 126. D. rhabdomyoma of pigs
86.D. metaplasia 127. E. lymphosarcoma of cattle
87.E. anaplasia 128. Answer: B
88.Answer: D 129.
89. 130. 34. which one of the following
90.29. which one of the following breeds has the highest "risk" to
neoplasms is commonly associated various kinds of neoplasms?
with femininity in male dogs? 131. A. boxer dog
91.A. pheochromocytoma 132. B. german shepherd dog
92.B. interstitial cell tumor 133. C. arabian horse
93.C. granulosa cell tumor 134. D. jersey cow
94.D. sertoli cell tumor 135. E. great dane dog
95.E. seminoma 136. Answer: A
137. 174. D. cryptorchism in the dog and
138. 35. the highest incidence of horse
ocular squamous cell carcinomas is 175. E. acute inflammation in the
most likely to occur in: colon of aged horses
139. A. angus cattle 176. Answer: E
140. B. hereford cattle 177.
141. C. holstein cattle 178. 40. the most common
142. D. shorthorn cattle neoplasm of the equine skin is
143. E. grey horses considered to be:
144. Answer: B 179. A. melanoma
145. 180. B. malignant melanoma
146. 36. the highest incidence of 181. C. sarcoid
osteogenic sarcoma is most likely to 182. D. mast cell tumor
occur in: 183. E. squamous cell carcinoma
147. A. boston terrier and scottish 184. Answer: C
terrier 185.
148. B. pekingese and chihuahua 186. 41. a neoplasm consisting of
149. C. great dane and st. bernard large oval cells with cyoplasmic
150. D. poodles and pomeranian granules that stain metachromatic
151. E. hereford and holstein cattle with "toluidine blue" is most likely a:
152. Answer: C 187. A. histocytoma
153. 188. B. squamous cell carcinoma
154. 37. which one of the following 189. C. hemangiopericytoma
is not true for neoplasms in animals? 190. D. mastocytoma
155. A. overall incidence of 191. E. oral papilloma
neoplasms is greater in female dogs 192. Answer: D
than in males 193.
156. B. overall incidence of 194. 42. each of the following has
neoplasms is greater in male cats been reported in animal species
than in females other than the dog except:
157. C. malignant lymphomas occur 195. A. hemangiopericytoma
more commonly in male cats than in 196. B. hemangiosarcoma
females 197. C. mastocytoma
158. D. malignant lymphomas 198. D. rhabdomyoma
occur more commonly in female 199. E. myxosarcoma
cattle than in male cattle 200. Answer: A
159. E. benign mixed mammary 201.
neoplasms occur more frequently in 202. 43. which one of the following
male dogs than in female dogs breeds is predisposed to the
160. Answer: E development of both mastocytomas
161. and histocytomas of the skin?
162. 38. the neoplasms least likely 203. A. german shepherd
to regress spontaneously is: 204. B. shetland sheepdog
163. A. histocytoma of dogs 205. C. border collies
164. B. mast cell tumor of dogs 206. D. boxer
165. C. canine venereal tumor of 207. E. st. bernard
dogs 208. Answer: D
166. D. oral papillomas of dogs 209.
167. E. cutaneous papillomas of 210. 44. which one of the following
cattle neoplasms of the dogs skin is most
168. Answer: B likely to be small in size (less than 2
169. cm in diameter), domed-shaped,
170. 39. which one of the following grows rapidly, consists of cells with a
is least likely to act as a high miotic index, never
precancerous lesion in animals? metastasizes, and occurs most
171. A. benign neoplasms frequently in young animals?
172. B. papillomas of the bovine 211. A. mastocytoma
eye 212. B. squamous cell carcinoma
173. C. melanoblastic activity in the 213. C. hemangiopericytoma
skin of old grey horses 214. D. perianal gland tumor
215. E. histocytoma 244. B. bovine cutaneous papilloma
216. Answer: E virus may induce connective tissue
217. neoplasms in a variety of animal
218. 45. the neoplasm that occurs species under experimental
with the highest frequency in the dog conditions
is: 245. C. cattle can be immunized
219. A. mastocytoma against cutaneous papillomatosis so
220. B. malignant lymphoma that they are resistant to subsequent
221. C. squamous cell carcinoma infections
222. D. osteogenic sarcoma 246. D. bovine cutaneous
223. E. histocytoma papillomas are caused by rna viruses
224. Answer: B which belong to the papova virus
225. group
226. 46. the presence of gastric 247. E. bovine cutaneous
ulcers, ulcers of the duodenum, focal papillomatosis usually affect cattle
glomerulitis, defects in immunologic under 2years of age and the head,
responsiveness, and a prolonged neck, and shoulders are the most
clotting time in a dog is most likely to common body sites affected
be associated with: 248. Answer: D
227. A. histocytoma 249.
228. B. pheochromocytoma 250. 49. the following are features
229. C. mastocytoma of the intracutaneous cornifying
230. D. squamous cell carcinoma epithelioma except:
231. E. osteogenic sarcoma 251. A. occurs only in the dog and it
232. Answer: C is limited to the skin
233. 252. B. does not metastasize;
234. 47. which one of the following however, multiple skin mases may
is not true for an hemangioma and/or develop
hemangiosarcoma: 253. C. norwegian elkhound is
235. A. hemangiosarcoma is a predisposed to the neoplasm and
highly malignant neoplasm and multiple skin masses usually occur
metastasis occur early since the 254. D. oftentimes referred to as a
neoplastic cells have easy access to keratoacanthoma and/or squamous
vascular channels papilloma
236. B. the spleen, right heart, and 255. E. caused by a rna herpesvirus
liver are common sites of origin for 256. Answer: E
hemangiosarcomas, whereas 257.
hemangiomas occur most frequently 258. 50. which of the following
in the skin and subcutis neoplasms has a tendency to
237. C. evidence suggest that develop in areas of unpigmented
hemangiosarcomas arise de novo skin:
rather than from pre-existing 259. A. squamous cell carcinoma
hemangiomas 260. B. mastocytoma
238. D. hemangiomas have a 261. C. basal cell epithelioma
tendency to metastasize to the lungs 262. D. histocytoma
since the tumor cells have easy 263. E. hemangiopericytoma
access to the bloodstream 264. Answer: A
239. E. the german shepherd is the 265.
breed most commonly affected with 266. 51. a neoplasm characterized
heman giosarcomas, whereas there by the presence of "cancer pearls"
is no known breed predisposition for and intercellular bridges is most
hemangiomas likely a:
240. Answer: D 267. A. basal cell epithelioma
241. 268. B. pheochromocytoma
242. 48. which one of the following 269. C. squamous cell carcinoma
is not true for cutaneous papilloma of 270. D. histocytoma
cattle? 271. E. perianal gland adenoma
243. A. bovine cutaneous papilloma 272. Answer: C
virus will cause fibropapillomas of 273.
the genital mucosa of cattle
274. 52. the most common cross-sections, and "cigar-shaped"
epithelial cell skin neoplasm in the with rounded blunted ends in long
dog is: longitudinal sections is most likely a:
275. A. squamous cell carcinoma 307. A. fibrosarcoma
276. B. sebaceous gland tumors 308. B. leiomyoma
277. C. sweat gland tumors 309. C. neurofibroma
278. D. trichoepitheliomas 310. D. rhabdomyoma
279. E. basal cell epithelioma 311. E. equine sarcoid
280. Answer: B 312. Answer: B
281. 313.
282. 53. which one of the following 314. 57. smooth muscle neoplasms
breeds seems to be predisposed to are infrequently reported in animals.
basal cell epitheliomas, sebaceous in large animals mos leiomyomas
cell tumors, and perianal gland occur in:
adenomas 315. A. heart
283. A. boxer 316. B. intestinal tract
284. B. german shepherd 317. C. vagina and uterus
285. C. norwegian elk hound 318. D. stomach
286. D. cocker spaniel 319. E. ovaries and kidneys
287. E. weimaraner 320. Answer: C
288. Answer: D 321.
289. 322. 58. which one of the following
290. 54. neoplastic masses located is not true for neoplasms of striated
adjacent to the anus of a dog in muscles?
which the cut surface is tan and 323. A. the diagnosis of striated
lobulated is most likely a: muscle neoplasms depends on
291. A. sweat gland tumor microscopic demonstration of cross-
292. B. squamous cell carcinoma striated filaments in at least one cell
293. C. perianal gland adenoma which is clearly part of the neoplasm
294. D. malignant melanoma 324. B. the great majority of benign
295. E. histocytoma striated muscle
296. Answer: C neoplasmas(rhabdomyomas have
297. been reported as occurring in the
298. 55. which one of the following heart
is not true for melanocytic 325. C. striated muscle neoplasms
neoplasms in domestic animals: are rare as naturally occurring
299. A. in dogs, most oral phenomena
melanocytic neoplasms are 326. D. most benign striated
malignant, whereas most cutaneous muscle neoplasms(rhabdomyomas)
melanocytic neoplasms are benign are considered to be congenital in
300. B. there is a tendency for aged origin
grey horses to develop melanocytic 327. E. malignant striated muscle
neoplasms; the highest incidence neoplasms(rhabdomyosarcoma) do
occurs in the arabian breed not arise in sites where no striated
301. C. in dogs, the highest muscle is ordinarily found
incidence of melanocytic neoplasms 328. Answer: E
occurs in breeds with greater skin 329.
pigmentation 330. 59. malignant neoplasms
302. D. in swine, melanocytic originating from bone occur primarily
neoplasms usually occur congenitally in:
or in very young animals 331. A. cats
303. E. the dopa reaction is not a 332. B. dogs
reliable means of identifying 333. C. horses
melanocytes in malignant 334. D. swine
melanocytic neoplasms 335. E. goats
304. Answer: E 336. Answer: B
305. 337.
306. 56. a neoplasm composed of 338. 60. which one of the following
interlacing bundles of fiber in which is not true for osteogenic sarcoma in
the nuclei are centrally located in dogs:
339. A. neoplasms occur more 369.
frequently in the front limbs than in 370. 64. which one of the following
the rear limbs is not a feature in dogs with
340. B. very high serum alkaline hormone-secreting sertoli cell
levels are definitive indicators of the tumors?
neoplastic disease 371. A. enlargement of the
341. C. neoplasms are more likely mammary gland
to develop on the distal end of the 372. B. squamous metaplasia of
radius and proximal end of the prostatic acinar epithelial cells
femur; the elbow joint is seldom 373. C. bilateral symmetrical
involved alopecia
342. D. neoplasms of the ribs are 374. D. atrophy of the uninvolved
usually located near the testis
costochondral junction and they tend 375. E. hyperkeratosis,
to occur more often in young adult parakeratosis, and acanthosis of the
dogs skin
343. E. neoplasms of the skull 376. Answer: E
occurs most commonly in the boxer 377.
breed 378. 65. the following statements
344. Answer: B are true for transmissible venereal
345. tumors of the dog except:
346. 61. osteogenic sarcomas are 379. A. the exact cell of origin is not
least likely to occur in: definitely known
347. A. great danes 380. B. female dogs have a higher
348. B. german shepherds incidence than males
349. C. pekingese 381. C. significant and constant
350. D. irish setter karyotypic differences exist between
351. E. st. bernard normal dog cells and cells of the
352. Answer: C neoplasm
353. 382. D. neoplasms are most
354. 62. which of the following is common during the years of greatest
not true for malignant sexual activity
lymphoma(lymphosarcoma) in cats: 383. E. in nature, neoplasms are
355. A. it is the most common induced by a herpesvirus
neoplasm of cats 384. Answer: E
356. B. most cats are dead within 385.
8-weeks after the neoplasm is 386. 66. the majority of mammary
detected gland neoplasms reported in the dog
357. C. the most common anatomic are:
form is the "alimentary" 387. A. benign mixed mammary
358. D. a leukemic blood picture is tumors
a characteristic feature of malignant 388. B. malignant mixed mammary
lymphoid neoplasms tumors
359. E. there are no good 389. C. myoepitheliomas
immunologic or epidemiologic data 390. D. adenocarcinomas
to support the idea of transfer of 391. E. adenomas
feline lymphosarcoma virus from cat 392. Answer: A
to man 393.
360. Answer: D 394. 67. which one of the following
361. is not true for mammary gland
362. 63. a neoplasm in which neoplasms in the dog?
epithelial cells and lymphoid cells are 395. A. ovariectomy has a sparing
essential neoplastic components is effect on the formation of mammary
most likely a: neoplasms in dogs, especially when
363. A. pheochromocytoma performed prior to the first estrus
364. B. chemodectoma cycle
365. C. adamantinoma 396. B. the highest incidence of
366. D. thymoma mammary neoplasms occur in the
367. E. dysgerminoma two most caudal mammary glands of
368. Answer: D dogs
397. C. mixed mammary neoplasms 407. E. primary fixation of the
are derived from more than a single neoplasm in potassium dichromate
germ layer or from more than one (zenker's etc.) give a positive
derivative of a single germ layer chromaffin reaction which is helpful
398. D. in cats, most mammary in making a definitive diagnosis
neoplasms occur in cranial two 408. Answer: C
mammary glands 409.
399. E. a mixed mammary 410. 69. the most common primary
neoplasm is composed of multiple intraocular neoplasm encountered in
tissues foreign to the part in which animals is:
they arise 411. A. squamous cell carcinoma
400. Answer: E 412. B. malignant melanoma
401. 413. C. malignant lymphoma
402. 68. which of the following is 414. D. astrocytoma
not true for pheochromoctyomas 415. E. benign melanomas
403. A. most common neoplas 416. Answer: B
arising from the adrenal medulla in 417.
cattle and dogs 418. 70. a benign neoplasm derived
404. B. norepinephrine is the from glandular epithelial cells is
principal catecholamine extracted referred to as:
from the neoplasm in dogs 419. A. papilloma
405. C. in cattle, the neoplasm 420. B. polyp
elicits nymphomania behavior 421. C. carcinoma
406. D. there is a tendency for 422. D. adenoma
larger neoplasms to invade into the 423. E. sarcoid
posterior vena cava 424. Answer: D