UNIVERSITY OF GONDAR

COLLEGE OF MEDICINE AND HEALTH SCIENCES

SCHOOL OF BIOMEDICAL AND LABORATORY SCIENCES

DEPARTMENT OF MEDICAL MICROBIOLOGY

Global Burden of Salmonellosis and Shigellosis in diarrheic Pediatric

Population

By: - Amare Alemu (Bsc)

Advisors: - Setegn Eshetie (Bsc, Msc)
Tigist Engida (BSc, MSc)

December, 2017
Gondar, Ethiopia
ACKNOWLEDGEMENT
I would like to thank Setegn Eshetie and Tigist Engida to let me come up with this valuable
seminar topic and offering for their tremendous technical support. I would like to extend my
gratitude to School of Biomedical and Laboratory Sciences and Department of Medical
Microbiology for enrolling me as MSc student.
Contents
ACKNOWLEDGEMENT ................................................................................................................................... 2
Abbreviations ................................................................................................................................................ 4
Summary ........................................................................................................ Error! Bookmark not defined.
1. Introduction ............................................................................................... Error! Bookmark not defined.
1.1. Background ......................................................................................... Error! Bookmark not defined.
2. Literature review ........................................................................................ Error! Bookmark not defined.
2.1. General Characteristics of Salmonella and shigella species ............... Error! Bookmark not defined.
2.2. Classification and nomenclature......................................................... Error! Bookmark not defined.
2.3. Epidemiology....................................................................................... Error! Bookmark not defined.
2.4. Transmission ....................................................................................... Error! Bookmark not defined.
2.5. Pathogenesis ....................................................................................... Error! Bookmark not defined.
2.6. Virulence factors ................................................................................. Error! Bookmark not defined.
2.7. Clinical manifestations ........................................................................ Error! Bookmark not defined.
2.8. Diagnosis ............................................................................................. Error! Bookmark not defined.
2.9. Treatment, prevention and control .................................................... Error! Bookmark not defined.
3. Significance of the review .......................................................................... Error! Bookmark not defined.
4. Methods ..................................................................................................... Error! Bookmark not defined.
4.1. Search strategies ................................................................................. Error! Bookmark not defined.
4.2. Study selection .................................................................................... Error! Bookmark not defined.
5. Conclusion .................................................................................................. Error! Bookmark not defined.
6. Reference ................................................................................................... Error! Bookmark not defined.
Abbreviations
AIDS--------------------------------------Acquired Immuno Deficiency Syndrome
CDC---------------------------------------Centers of Disease Control
EIEC-------------------------------------- Enteroinvasive Escherichia coli
GALT------------------------------------- Gastrointestinal Associated Lymphoid Tissue
HCL----------------------------------------Hydrochloric Acid
HIV-----------------------------------------Human Immuno Virus
IpaB--------------------------------------- Invasion of plasmid antigen B
LPS----------------------------------------- Lipopolysaccharide
MLST---------------------------------------Multiple Loci Sequencing typing
NTS----------------------------------------- Non-Typhoidal Salmonella
PFGE -------------------------------------- Pulse-Field Gel Electrophoresis
PMNs---------------------------------------Polymorphonuclear Cells
RES---------------------------------------- Reticuloendothelial System
T3SS--------------------------------------- Type III-Secretion-System
WHO---------------------------------------World Health Organization
USA----------------------------------------United States of America