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Adrenergic Agonists
PharmaIdea Publications ©
Adrenergic Agonists
Tyramine -can enter nerve terminals and displace -not clinically -found in fermented foods (ripe
(Indirect) stored NE useful cheese, Chianti wine)
-released catecholamines act of -normal byproduct of tyrosine
adrenoceptors metabolism
-oxidized by MAO in GIT, but if
patient is on MAO inhibitors, it
can cause vasopressor episodes
Cocaine -blocks the Na+/K+ ATPase which is α, β -pts taking cocaine have greater
(Indirect) required for uptake of NE effects produced by small doses
-increases blood pressure by α- of catecholamines and longer
stimulatory action on vasculature and β- duration of action
effects on the heart
Ephedrine -release stored NE and also directly α, β, CNS -Ephedrine: -Long duration of -plant alkaloids, now made
Pseudo- stimulate the receptors prophylactic in action synthetically
ephedrine -penetrate into CNS, but pseudo has chronic treatment -Excellent -poor substrates for COMT and
(Mixed-action) less CNS effects of asthma absorption orally MAO
-Ephedrine raises systolic and diastolic -Ephedrine: -Ephedrine -Pseudo has been illegally
pressures by vasoconstriction and enhances eliminated in urine, converted into
cardiac stimulation contractility and unchanged methamphetamine
-Ephedrine produces bronchodilation, motor function in -Pseudo partially
more slowly and less potency than EPI myasthenia gravis metabolized in
or ISOPROTERENOL -Ephedrine: raise liver, then
-Ephedrine causes stimulation of CNS BP eliminated in urine
resulting in increased alertness, -Pseudo: nasal and
decreased fatigue, prevents sleep, sinus congestion or
improved athletic performance congestion of
Eustachian tubes
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