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IDIAL GUID TO
RHEUMATOLOGY
HISTORY TAKING & CLINICAL EXAMINATION
WITH 22 CASES
(1)
Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Rheumatology Sheet
1. A good history & physical examination, with good idea about the
musculoskeletal anatomy is very important for diagnosis;
You must examine the patient!!
2. Don’t order a lab test unless you know why & what you will do if
it is abnormal?
3. Acute monoarthritis = joint aspiration to exclude septic & crystal-
induced arthritis.
4. Chronic monoarthritis > 8 weeks of unknown cause needs
synovial biopsy.
5. Gout does not occur in premenopausal females or in joints close
to spine.
6. Most shoulder pain is periarticular (bursitis, tendonitis..),
most LBP. is nonsurgical.
7. OA in (MCP, wrist, elbow, shoulder, ankle) joints ---- exclude 1ry
cause eg. Metabolic dis.
8. 1ry fibromialgia does not occur > 55ys. for 1st time, nor with
abnormal laboratory results.
9. Not all pts. With +ve RF=RA, nor +ve. ANA = SLE .
10.Fever or multisystem complaints, in Rhc. Pt., rule out infection &
other non-Rhc. causes as a 1ry.
(Infections cause death in Rhc. pt. more than the 1ry dis. does).
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Terminology
Rheumatism:
1st. introduced in 1642 when they realized that arthritis could be a
systemic disease. It was an obsolete term for ARF. Now it is defined as
various abnormal conditions marked by recurrent pain, stiffness &
other manifestations of articular origin in joints, back, or muscles.
Capsule= The thick membrane that joins bones making up a joint. It also
isolates the joint cavity from surrounding tissue.
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Carpal tunnel = The space at the flexor aspect of the wrist bounded by
the carpal bones and the flexor retinaculum. Flexor tendons and the
median nerve traverse the carpal tunnel
Personal History
Age:
Young: ARF (5-15), HSP (4), Kawasaki (5)
Middle age: RA (all ages), SLE, PAN (40), RP (20-40), Reiter (20-40yrs.),
Takayasu (15-25), Wegner (40)
Old: OA, Giant Cell Arteritis (GCA>50), Gout (50yrs)
Sex:
F>M M>F M=F
Habits:
Addicts---------- viral, infectious arthropathy
(7)
Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Residency:
Crowded humid damp area: ARF
Occupation:
Vibrating tools, pianist, typist------- RP
Health providers, blood bank staff ------ Viral arthropathy, cryo, vascul.
Past History
Precipitating factors???
Drugs:
Drug-induced Lupus eg.: Hydralazine, Methyl dopa, Procainamide,
Phenytoin, Isoniazid, Chlorpromazine.
BB-------RP.
Lovastatin------Myositis.
L-tryptophan-------Esinophelia-myalgia syndrome.
Infections:
B haemolytic streptococcal A. infection----------ARF
TB
Gonorrhea
Sepsis
Diet:-----------Delayed hypersensitivity reaction------ Arthropathy.
Trauma: Fracture, Haemarthrosis.
Joint Surgery: Open, Laparoscopic, Aspiration:-
Indications, results, & follow up.
Response to previous therapeutic modalities: drug TTT, PT, surgical
corrections----------- clues for diagnosis, effects, side effects, compliance.
Complaint:
Chief symptom & its duration
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
I- Pain:
SITE: Where exactly is the pain experienced? (Ask the
patient to point). Site of maximum intensity= localizing pathology.
Diffuse pain, variable, poorly described, or unrelated to anatomical
structures= fibromialgia, malingering, or psychogenic.
RADIATION: Does the pain radiate elsewhere? = Neuropathy.
CHARACTER.
SEVERITY: visual analog scale 1-10 (intolerable pain in pt. doing normal
activities=psychogenic)
ONSET, COURSE & DURATION, continuous or intermittent?
FREQUENCY
DIURNAL VARIATION
Rest pain = inflammatory (RA).
Usage pain = mechanical (OA).
PRECIPITATING-FACTORS, trauma,….
WHAT Increase, WHAT Decrease
ASSOCIATED SYMPTOMS, stiffness, redness or swelling
IMPACT ON GENERAL CONDITION & LIFE STYLE (sleep and
functional capacity -- in relation to work? On normal daily life?
Associated extra articular symptoms (skin rashes, eye inflammation
etc.).
PAST HISTORY OF SIMILAR ATTACKS, infections, autoimmune
diseases,… any relevant past medical history?.
II- Stiffness:
Joint tightness d.t. accumulation of inflammatory exudates & edema
fluids--- distention of the periarticular tissues (capsule, tendosynovium,
bursa). After activity; fluids washout from the inflammatory tissues &
stiffness wears off.
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
III- Swelling:
Bony (hard), fluid (+ve fluctuation) or synovial thickening (firm
in consistency).
Specify & count the swollen joints.
Diffuse or localized.
Constant or episodic.
Duration.
+ Signs of inflammation (pain, hotness, redness & limitation of
movement).
IV- Deformity:
Fixed or correctable?
Characteristic & specific?
V- Movement (Function):
Normal painless daily activity?
Painful daily activity?
Limited movements?
No movement (ankylosis)?
Disability (unable to perform ordinary important movements, need for
house hold help) or handicapped (necessitates change of the life style
&/or change or retirement from job)? = severity
Skin:
Overlying traumatic/surgical scars or skin discoloration= clue for
diagnosis.
Erythematous joint=sepsis or crystal.
Rash (malar, photosensitivity, = SLE, purpuric eruptions= Vasculitis).
Adherent silver-like plaques = Ps A.
Subcutaneous nodules: RA, SLE, RcF, PAN, Sarcoidosis.
Tophi: Gout.
Alopecia: SLE, SSc
Raynaude’s phenomena (pallor, cyanosis then erythema): SSc, SLE,
RA, PM/DM, Vasc.
Sclerodactyly, digital ulcers & gangrene: SSc.
Palmar erythema: RA (most common pathologic cause>liver c. &
thyrotox.), while pregnancy is the most common physiologic cause.
Keratoderma blenohemorrhageca= Reiter.
Nail changes:
Clubbing: hypertrophic pulmonary osteoarthropathy & fibrosing alveolitis
(in SSc).
Pitting, onycholysis, dystrophy: psoriasis, chronic Reiter’s syn.
Splinter hge.: Vasculitis.
Mouth:
Xerostomia, dysphagia: Sjogren (SS)
Ulcers + genital = Behcet, SLE, Vasculitis (painful) & Reiter (painless).
Eye:
Xerophthalmia: Sjogren (SS) (usually asymptomatic)== Schirmer test
(screening, confirmed by Rose Bengal stain & slit-lamp. D: lip
biopsy).
Conjunctivitis: acute Reiter, SS.
Episcleritis & scleritis: RA, Vasculitis.
Iritis: AS, chr. Reiter.
Iridocyclitis: pausiarticular juvenile chr. arthritis.
Cardiopulmonary:
Dyspnea, chest pain, cough, haemoptysis: pleurisy, pericarditis
(SLE, RA, SSC), vasculitis, pulmonary embolism & infarction, CHF, IHD,
…
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Endocrinal arthropathy:
DM----------Neuropathic or septic arthritis.
Hypothyroidism: carpal tunnel S., & myopathy.
Hyperparathyroidism: pseudogout. Acromegaly: sever OA.
GIT:
Reflux, dysphagia---- SSC.
Abd. Pain, bleeding per rectum, diarrhea,= IBD--AS, Vasculitis.
Jaundice = Viral hepatitis with arthropathy or vasculitis, cryoglobuline.
Genitourinary:
Urithritis (dysuria, dyscharge)—Reiter, Gonorrhea,..
Ulcers--- Reiter, Behcet.
Hematological:
Anemia, leukopenia, thrombocytopenia = SLE, BM depression by
drugs, hypersplenism in RA.
DVT, fetal losses= APS.
Hemochromatosis—sever OA.
CNS:
Neuropathy, fits, behavioral changes, weakness, TIA, strokes = Lupus
cerebritis, vasculitis.
Temporal headache = GCA.
Family history
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Ligament==
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Tendon==
Muscle==
Acute Chronic
Duration <6 weeks >6 weeks
Ex. *Infectious arthritis. *RA.
*Night pain.
Inflammatory Non-inflammatory
MS >1hr. <1/2 hr.
Fatigue Significant. Minimal.
Activity Improve symptoms. Worsen.
Rest Worsen Improve.
Systemic ++ --
manifestations
ESR, CRP ++ --
Corticosteroid Improve No effect
Ex. RA. OA.
Systemic rheumatic dis. Traumatic.
(SLE, SSC, Vas.). Osteonecrosis.
Infect.: Bact, Viral. Neuropathic J.
Crystal. Metabolic
Reactive (Reiter, RF). (hemochromatosis),
Seroneg. (AS,IBD).
Sarcoidosis, FMF,.. Endocrinal (thyroid,
DM, Acromegaly)
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
* 1 joint = Monoarticular.
Acute Monoarthritis:
Inflammatory Noninflammatory
Crystal Traumatic
Spondyloarthropathy Osteonecrosis
Palindromic Rheumatism
Chronic Monoarthritis:
Inflammatory Noninflammatory
Infectious: TB, Fung, Lyme. OA
Crystal. Osteonecrosis
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Symmetrical Asymmetrical
Ex. RA Reiter
SLE
PsA
AS
Peripheral Axial
Ex. RA AS
SLE
PsA (70%-also affects
IPJ--- sausage digits)
Reiter
Small Large
Ex. RA Seronegative
SLE
Reiter
RF
Rheumatological Examination
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
General Examination
Pulse:
Rapid due to Anemia, fever (ARF or activity, SLE, infections)
Tachycardia out of proportion of fever (1ºc=10 b/m)= myocarditis
Bradycardia (HB), arrhythmia= SSc
Blood Pressure:
HPT = SLE, Vasculitis, SSc, RA + renal, CVS---drugs?
Hypo. = HF, dehydration, bleeding!
Pallor
Activity of CTD (anemia of chronic disease).
Anemia (hemolytic, iron def. bl. loss, aplastic-drugs, ..)
Cyanosis
IPF=SSc, RA (bronchiolitis, fibrosing alveoltis, Caplan’s lung),
Bilateral or extensive pleural effusion= SLE
Pericardial effusion=SLE
Ht. failure
Jaundice
Hemolytic = SLE
Drugs
Viral hepatitis associated with or causing arthritis.
Cryoglobulinemic arthritis in hepatitis pt.,Vasculitis.
Face
Malnutrition =TB, malignancy, sever disease, drugs.
Cushingoid= steroid, endocrinal arthropathy.
Alopecia=SLE, Drugs, SSc
Butter fly rash sparing the nasolabial fold=SLE
Heiotrope rash (puple-erythematous discoloration of upper eye
lid, nasolabial, forehead+ periorbital oedema)= DM.
Eye
Colors
Dry (xerophthalmia)=SS
Cataract: premature, posterior capsular=Steroid, chloroquine.
Puffiness: L. nephritis, NS, Amyloid, Drugs
Mouth
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Dry (xerostomia) = SS
Ulcers (B, R, SLE).
Neck:
Thyroid swelling – autoimmune + SLE, hypothyroid with carpal
tunnel, hypo or hyperthyroid with proximal muscle weakness.
Neck veins: CHF, SLE, NS, Pericaldial, pleural effusion,
LN: RA, Felty, SLE.
Hand
Clubbing: Fibrosing alveolitis in RA, SSc, IBD, hyperthyroid
Nail pitting, loss of luster, splitting= PA.
Onycholysis (separation of distal end from its plate):PA, thyrotox.
Splinter hemorrhage, tender Osler nodes at finger pulps (tender
palpable nodules)& Janeway lesions=palpable purpuric spots on
palm dt. microthrombi—necrotic lesions: RF+ SBE
Sclerodactyly: smooth, shiny, tapered fingers with taut, bound
down skin.
Palmar erythema: RA
Mus wasting: RA (interossei), carpal t. S (thenar).
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Mechanics hand= DM
Skin:
Characteristic rash: Butterfly malar, descoid,
photosensitive=SLE
Psoriatic lesions (well-defined, raised itchy erythematosus
plaques covered by a loosely adherent silvery scales) =PA.
(20)
Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Purperic eruptions,
Raised =Vasculitis
Flat=thombocytopenic purpera= SLE,
Felty, drugs (gold, D- penicillamine)
V-sign, Shawl-sign rash=PM/DM
LL:
Oedema= NS, LN, amyloidosis (RA, Drugs), DVT (SLE, APS),
Ulcers: Vasculitis + Still’s, RA, SLE. Or hemolytic anemia.
Ischemia: Vasculitis.
Keratoderma blennorrhagicum =vesicles, pustules, on palms
& soles with thick hyperkeratotic plaques =Reiter
Genitalia:
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Genital & Oral Ulcers = Behcet (on scrotum or labia, may penis
or vagina), Reiter (with circinate balanitis= confluent eroded red
papules on corona & glands penis)
Heart:
Carry Coomb's murmur (Oedema of MV) = ARF
SLE----Libman-Sacks endocarditis=verrucous---post. Leaflet MV
Pericarditis, myocarditis, IHD, systemic, pulmonary HPT = SLE
& Vasculitis
Ankylosing Spondylytis--AR
Chest:
Pleurisy, effusion=SLE, RA VAS.
Pneumonitis, Alveolitis, Caplan's lung = RA
Pulmonary embolism, inf= APS
Abdomen:
Splenomegaly = Felty, JRA
HSM= SLE, RA
CNS:
PN, Lateralization, muscle weakness = Vas, SLE,
Entrapment neuropathy = RA
PM/DM
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Local Examination
Physical examination of the locomotor system is extensive &
complex; so, a brief screening procedure to pick up problems in certain
regions is more appropriate. If an abnormality is detected, more detailed
examination of the affected region can be undertaken.
Tenosynovitis:
Joint positioned to decrease tension on tendon.
Decreased movement in the plan of tendon.
Selective stress pain.
Linear swelling & tenderness.
+ Fine cripitus. + triggering.
Mechanical arthritis:
Abnormal shape (deformed joint).
Coarse cripitus.
Decreased movements in all planes.
+ Ligamentous stress pain/instability.
+ Synovitis.
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Rheumatologic
Examination
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Inspection
Attitude = Position of the affected area at rest.
Swelling.
Deformity.
Muscle wasting.
Skin changes over the affected MSK area (erythema,
discoloration or scars). Telangiectasia, rash, or bruising.
Symmetrical affection of MSK elements.
Palpation
Warmth = inflammation.
Tenderness (diffuse or localized).
Swelling (hard, cystic fluctuation or firm).
Deformity (correctable or not), dislocation or subluxation.
Cripitus =audible & palpable during movement (fine, or
coarse).
Muscle state (normal or atrophied) & muscle power.
Movement
Active = by the patient
Passive = by the examiner
ROM (range of movement)=depends on age, sex & race.
Stress test (moving joint passively toward its limitation) =
universal=all direct. in synovitis, selective in localized lesions.
Resisted active movement= test periarticular (ms, tn, en)
*Synovitis= restricted both active & passive movements in
all planes of ROM.
*Myositis, bursitis, tendenitis….= restricted active with
normal passive movements, only in the plane.
Joint stability.
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
I) Upper Limbs:
a) Hands=MCP, PIP, DIP J.
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Z-shaped thumb
Movements:
Open & spread the fingers (extension & abduction).
Fist=Close all fingers (flex, add.) to reach the palm &
thumb closes over them.
Grip=pt. maximum strength in grasping 2 fingers of the
examiner.
Pinch the tips of thumb with index finger.
Metacarpal squeeze: between the examiner’s thumb &
fingers proximal to metacarpal heads if tender= arthritis.
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
b) Wrists=radiocarpal J.
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Movements: 09VH,W03.WMV
Prayer position =full extension & dorsiflexion75 ْ .
Full flexion=planter flexion 70 ْ.
Ulnar deviation 45 ْ & radial deviation 20 ْ.
Carpal tunnel syndrome provocation:
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
olecranon bursitis.
Synovitis= firm, tender, hot swelling at fossae between
olecranon & medial or lateral epicandyles.
Subcutaneous nodules & tophi, at or below olecranon.
(33)
Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Movement: 09veb04.wmv
Bend (flex=0-150ْ) & straighten both elbows (ext=0ْ).
ْْWith elbows flexed at 90 ْ & fixed to his side (to prevent
shoulder movements) ask pt. to turn palms up (supination
0-90 ْ ) & down (pronation 0-90 ْ ) using thumb as
indicator.
Resisted active movements:
Lateral epicondylitis & Medial epicondylitis.
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Winging of the scapula due to a palsy of the long thoracic nerve. The
appearance of winging may be exaggerated by asking the patient to hold
the arms out in front of him and especially if they push against something
at the same time. .
Movements: 09vsh05.wmv
(Flexion, extension, abduction, adduction & rotation)
Pt. put both hands behind the head with elbows pointing
laterally (abd, flx., & ext. rot).
Hands down, hands behind back & thumb pointing up
marking the highest vertebra pt. can touch by each side
(ext., add. & int. rot.).
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Measurement:
True leg length=from ASIS—lateral maleolus (to
detect congenital or acquired disorders).
Apparent leg length= Umbilicus –medial maleolus (to
detect scoliosis, pelvic contractures--- pelvic tilt.
Movements:
Hip flexion 0-120° & extension -10°.
Internal 25° & external rotation 35° examined while
both hip & knee flexed 90°; using the tibia as indicator
for the angle of rotation.
Leg roll maneuver: to examine Internal 90° & external
rotation 90°while hip & knee are extended, using foot
as indicator for the angle of rotation.
The last 2 tests are sensitive for hip pathology.
Trendelenberg’s sign: 09v08.wmv
Normally on standing on normal leg, the pelvis tilts to the
same side. On standing on the side of the diseased hip, the pelvis
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
fails to tilt towards the same side, so, drops to the other
side=weak gluteus medius.
b) Knee
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
(38)
Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
tenderness=patello-femoral pathology.
Stability:
Lachman’s test =integrity of anterior cruciate ligament. Knee flexed
20, femur grasped with lt. hand & pulling tibia forwards with rt. hand.
Collateral ligaments: abduction & adduction (medial & lateral
displacement) stretch between tibia & femur while knee in flexion to
elicit any movement.
(39)
Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Deformities: Pes planus (flat foot= talar head displaced medially &
plantar-ward), pes cavus (high arch),
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Palpation:
Movements: 09VK,F06.WMV
III) Spine:
Inspection:
Normal cervical & lumbar lordosis (concavity to back) & thoracic
kyphosis (front concavity)
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Palpation:
For tenderness, warmth, muscle wasting, bony abnormalities.
Movements:
Cervical spine: notice any localized or radiating pain/
tenderness or limited mobility on active or passive:
Flexion=75, extension 60, Rt. & Lt. Rotation 80, Rt. & Lt.
bending 45.
Thoracic spine: Rt. & Lt. rotation at thoracolumbar 45.
Chest expansion = difference bet. full expiration & insp>6cm
Lumbar spine: Flexion 90, Extension 30, Lateral bending
(to touch sides of knees)15-30.
Lumbosacral: anterior flexion--- increased distance bet.
D12-L1>7cm.
Schober test: limited flexion ?AS.
Put a mark at the level of PSIS or lumbosacral j.&
another10 cm above, ask pt. to touch the toes with
extended knees, measure the distance bet. the 2 marks
should be>17cm.
Finger tips-floor distance <10cm =index for combined
hip & lumbosacral flexion.
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
09vsp09.wmv
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Level of lesion:
L4 root=lost knee reflex & weakness of quadriceps.
L5=weak extensor hallucis longus
S1=lost ankle reflex & weak soleus
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Sacroiliac Joint:
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
(47)
Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
(48)
Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Nonarticular: Articular?
Traumatic
Fibromyalgia
Acute or Chronic ?
Polymyalgia R.
Bursitis/tendenitis
Chronic>6W.
Acute<6 W.
Acute arthritis:
Inflammatory or noninfl.
Infectious
Crystal-induced
Reiter’s
Presentation of Chronic non-
Chronic inflammatory
Chr. Arth. arthritis= MS>1hr,
inflammatory
synovial swelling, warm,
arthritis
j.tender, syst. Manifes.,
CRP, ESR
>4 J = polyarthritis
1-4=mono-oligo A
Affects Wt. Br. J.
Chr. Inf.
(H&k)., DIP< CMC
PA- RS- PJA
Symetrical
PIP, MCP,
PA, RS
OA Osteonecrosis MTP
Charcotarthritis
RA
SLE, SSc, PM
Interpretation of Synovial fluid
09Vsum10.WMV
analysis
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Inflammatory or noninflammatory
articular condition? DD:
Traumatic or
mechanical.
Coagulopathy.
Neuropathic.
Is WBC>
2000/cmm?
Is PMNs>
75%?
Other Inflammatory or septic?
Gram stain & culture essential.
Are crystals present?
Common Presentations Of
WBC>50,000/cmm
Common Rheumatic
? Diseases: Gout or Pseudogout.
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
(51)
Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
20. Pain & tenderness at the lateral epicondyl & extensor mus.
Close to it dt. repetitive wrist extension or supination & pronation
increased by resisted active wrist extension= Tennis elbow=
lateral epicondylitis
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Reumatology Sheet Dr./ Abdel Azeim Alhefny,
MD.
Raynaud's phenomenon =
Blanching of the extremities on exposure to cold. It is usually followed by blue,
cyanotic discolouration on rewarming. It may occur in isolation or in association
with a connective tissue disease
References
Atlas Rheumatic diseases
Barbara Bates, A guide to physical examination & history taking, 6th ed , 1995.
Davidson's principles & practice of Medicine 19th ed. 2002.
Harrison's principles of Internal Medicine, 14th ed. 1998.
ILAR, EULAR Reumatology Web siteS
Kelly's text book rheumatology 6th ed. 2001.
Manual of Reumatology & outpatient Orthopedic disorders, 4th ed. 2000.
Medscape Reumatology Web sites
Oxford handbook of Rheumatology, 2002.
Rheumatology examination &injection techniques, 1992.
Rheumatology Secrets, 2nd. Ed. 2002.
WWW.oup.com
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