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Objective:5PDPNQBSFUIFEFHSFFPGSPPUSFTPSQUJPOJOFOEPEPOUJDBMMZUSFBUFEQSJNBSZ
molars with that of homologous teeth without root canal treatment. Method and Materials:
A retrospective study was carried out comprising 105 records of children who had
received root canal treatment in a primary molar. Mean age at the time of treatment was
7.0 ± 1.4 years. Inclusion criteria included one endodontically treated primary molar and
a homologous primary molar with no root canal treatment on the other side of the mouth.
All teeth were treated by the same operator in the same way using the same iodoform-
DPOUBJOJOHSPPUDBOBMGJMMJOHNBUFSJBM5IFEFHSFFPGSPPUSFTPSQUJPOXBTDPNQBSFECZ
radiographic evaluation 12 or more months posttreatment. Results5IFEFHSFFPGSPPU
resorption on the final follow-up radiograph in the endodontically treated primary molars
was significantly higher (P < .05) than the degree of root resorption in the homologous
UFFUI5IFEFHSFFPGSPPUSFTPSQUJPOXBTIJHIFSJOCPZTUIBOJOHJSMT/PTUBUJTUJDBM
significance was found between the degree of root resorption and the age at the time
of treatment in either the root canal–treated teeth or the homologous teeth. Follow-up
radiographs demonstrated a higher degree of root resorption in the root canal–treated
teeth than in the homologous teeth, regardless of the type of treatment performed on the
homologous side. Conclusion:3PPUDBOBMUSFBUNFOUQFSGPSNFEXJUIJPEPGPSNDPOUBJOJOH
root canal filling material accelerates root resorption in root canal–treated primary molars
compared with homologous teeth without endodontic treatment. Clinicians should be
aware that endodontically treated teeth will probably shed before homologous ones that
are not root canal treated. (Quintessence Int 2012;43:361–368)
A major goal of pulp therapy in the primary exhibits clinical signs of irreversible pulpitis,
dentition is the maintenance of arch-length infection, or necrosis.1 Expected clinical
integrity and the function of the teeth and outcomes of successful root canal treat-
their supporting tissue until physiologic ment include elimination of pain, abnormal
resorption of roots occurs and permanent mobility, sensitivity to percussion, and swell-
TVDDFTTPST FSVQU 3PPU DBOBM USFBUNFOU JOH 3BEJPHSBQIJD PVUDPNFT PG TVDDFTTGVM
is indicated in primary teeth with carious root canal treatment include resolution of
pulp exposure in which the radicular pulp the pretreatment radicular radiolucent area,
continued physiologic root resorption of the
primary tooth and the filling material, normal
1
Clinical Lecturer, Department of Pediatric Dentistry, The eruption of the permanent successor, and
Hebrew University-Hadassah School of Dental Medicine, the absence of pathologic root resorption
Jerusalem, Israel.
or enlargement of periapical radiolucency.
2
Private Practice, Jerusalem, Israel. 3PPU SFTPSQUJPO JO QSJNBSZ UFFUI JT B
3 Clinical Associate Professor, Department of Pediatric Dentistry, physiologic process that precedes tooth
The Hebrew University-Hadassah School of Dental Medicine,
shedding. Acceleration of root resorption
Jerusalem, Israel.
has been documented in cases of trauma
Correspondence: Dr Moti Moskovitz, Department of Pediatric
to primary incisors2 or primary molars3 and
Dentistry, Hadassah School of Dental Medicine, PO Box 12272,
Jerusalem 91120, Israel. Email: motimo@md.huji.ac.il in cases of pulpotomy treatment in primary
teeth.4,5 Premature loss of primary molars restoration at the final follow-up evaluation
can result in space loss, which may cause in at least one tooth (root canal–treated or
tipping of the permanent molar, crowding homologous). If a patient had more than
and lack of space in permanent dentition, one homologous pair meeting study criteria,
and impaction of permanent teeth, espe- one pair was randomly selected.
cially in cases with severe predisposition to Of 2,481 records searched, 105 met the
arch-length deficiency.6 5P UIF CFTU PG UIF inclusion criteria. Mean age at the time of
authors’ knowledge, no specific study has USFBUNFOU XBT ZFBST 5IF NFBO
published data on the effect of root canal follow-up time was 35.5 months (range, 12
treatment on root resorption in primary to 104 months).
NPMBST BGUFS SPPU DBOBM USFBUNFOU 5IF BJN
of the present study was to compare the Endodontic treatment
degree of root resorption in root canal–treat- All root canal treatments were performed
ed primary molars with iodoform-containing by the same surgeon (M.M.) using the
root canal filling material to that of homolo- TBNFNFUIPE5FFUITFMFDUFEGPSSPPUDBOBM
gous teeth that did not undergo endodontic treatment were primary molars with preop-
treatment. erative radiographic and/or clinical signs of
irreversible pulpitis or necrosis of the pulp
(ie, bifurcation radiolucency, dry necrotic
QVMQ
PS TJOVT USBDU
5IF UFFUI XFSF BOFT-
METHOD AND MATERIALS thetized and isolated with rubber dam.
Following caries removal, the pulp chamber
was exposed, and the affected pulp was
5IF TUVEZ QSPUPDPM XBT BQQSPWFE CZ SFNPWFE VTJOH B CBSCFE CSPBDI 5IF SPPU
the Institutional Human Subjects Ethics canals were prepared up to no. 30 files, irri-
Committee of the Hebrew University- gated with chlorhexidine and normal saline,
Hadassah School of Dental Medicine, BOEESJFEXJUIQBQFSQPJOUT5IFSPPUDBOBMT
Jerusalem, Israel. were filled with iodoform-containing root
canal filling material (Endoflas, Sanlor & Cia)
Study population using a Maillefer Lentulo spiral (Dentsply).
5IJTTUVEZXBTCBTFEPOEFOUBMSFDPSETPG Endoflas, which is FDA approved, com-
children aged 5 to 11 years treated at the prises a powder of triiodmethane and iodine
Dental Volunteers for Israel (DVI) Clinic in dibutyl-ortho-cresol (40.6%), zinc oxide
Jerusalem, Israel, between 1997 and 2007. (56.5%), calcium hydroxide (1.07%), and
Inclusion criteria were at least one pair of barium sulfate (1.63%), with a liquid consist-
homologous primary molars on the same ing of eugenol and paramonochlorophenol.
arch (maxillary or mandibular) in which one 5IF UFFUI XFSF SFTUPSFE XJUI JOUFSNFEJBUF
molar had received root canal treatment SFTUPSBUJWF NBUFSJBM *3.
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and the other had not, high-quality radio- treatments were completed in a single visit.
graphs taken shortly prior to the endodon- 5IF QBUJFOUT XFSF BTLFE UP SFUVSO XJUIJO
tic treatment, and high-quality radiographs month for coronal restoration, allowing peri-
taken at least 12 months posttreatment to odontal ligament (PDL) healing after root
enable assessment of the root canal treat- canal inflammation was resolved yet not
ment and the degree of root resorption. compromising tooth prognosis while adapt-
Exclusion criteria were early extraction ing a stainless steel crown. In the absence
of one of the paired teeth, a follow-up of clinical pathologic signs of inflammation,
period of less than 12 months, medically the root canal–treated primary molars were
compromised patients, the absence of a restored with a stainless steel crown or
permanent successor, teeth with preop- amalgam restoration if the remaining crown
erative external or internal pathologic root structure was sufficient for retention of the
resorption, teeth with enlargement of peri- SFTUPSBUJPO5BCMFQSFTFOUTUIFEJTUSJCVUJPO
apical radiolucency or the appearance of of treatment types of the homologous teeth
a new periapical radiolucency after root in relation to the restoration type of the root
canal treatment, and a temporary filling canal–treated teeth.
Table 1 Distribution of root canal–treated (RCT) primary molars according to the type of
restoration and type of treatment of the homologous teeth
Degree 1
Degree 2
Degree 3
Degree of root resorption Root canal–treated teeth (%) Homologous teeth (%)
2 2 (1.9) 0 (0.0)
3 14 (13.3) 4 (3.8)
4 89 (84.7) 101 (96.2)
5PUBM 105 (100) 105 (100)
Degree of root resorption Root canal–treated teeth (%) Homologous teeth (%)
0 24 (22.9) 10 (9.5)
1 36 (34.3) 19 (18.1)
2 30 (28.6) 19 (18.1)
3 5 (4.8) 22 (21.0)
4 10 (9.5) 35 (33.3)
5PUBM 105 (100) 105 (100)
Patient sex
Delta* Boys (%) Girls (%) Total (%)
0 7 (13.7) 4 (7.4) 11 (10.5)
1 8 (15.7) 3 (5.6) 11 (10.5)
2 8 (15.7) 19 (32.2) 27 (25.7)
3 15 (29.4) 23 (42.6) 38 (36.2)
4 13 (25.5) 5 (9.3) 18 (17.1)
5PUBM 51 (100) 54 (100) 105 (100)
*Delta, difference between the endodontically treated molar and the homologous tooth in degree of root resorption.
Pearson chi-square two-sided test, P < .05.
/P TUBUJTUJDBM TJHOJGJDBODF XBT GPVOE resorption at the final follow-up appointment
CFUXFFO B DIJMEAT BHF BU UIF UJNF PG UIF (P
/P TUBUJTUJDBM TJHOJGJDBODF XBT
root canal treatment and the degree of root found between teeth that were restored with
resorption at the final follow-up appoint- stainless steel crowns and teeth that were
ment, for either the root canal–treated teeth restored with amalgam filling (P > .05).
or the homologous teeth (P
/P TUB-
tistical significance was found between the
rate of root resorption and the time interval
between the root canal procedure and the DISCUSSION
DPSPOBM SFTUPSBUJPO PG UIF UPPUI 5IF NFBO
time from root canal treatment to coronal
restoration was 4.2 ± 7.9 months. 5P UIF CFTU PG UIF BVUIPST LOPXMFEHF
OP
5IF EFMUB PG SPPU SFTPSQUJPO JO UIF GJOBM specific study has published data on the
radiographs between root canal–treated teeth relationship between root canal treatment in
and homologous teeth was significantly high- primary molars and the rate of root resorp-
er in boys than in girls (Pearson two-sided tion in those teeth. In the present study,
DIJTRVBSF UFTU
5BCMF
BMUIPVHI root canal treatment using iodoform-con-
no difference was found between boys’ and taining root canal filling material was found
girls’ ages at the time root canal treatment to accelerate root resorption in endodon-
was performed and at the final follow-up. tically treated primary molars compared
/P TUBUJTUJDBM TJHOJGJDBODF XBT GPVOE with homologous teeth without root canal
between the type of primary molar (first or treatment. A radiographic case example
second), location (maxillary or mandibu- that demonstrates the discrepancy in the
lar), or side (endodontically treated teeth resorption process between root canal–
or homologous) and the degree of root treated and homologous teeth is presented
Fig 2 Initial bitewing radiographs, age 5 years and 4 months. Upon presentation, Fig 3 Root canal treatments were per-
there were clinical signs and symptoms of inflammation in the primary mandibular formed on the primary mandibular right
right first molar and the primary maxillary right first molar. first molar as well as the primary maxil-
lary right first molar.
One limitation of the study is that involve- 4. Peng L, Ye L, Guo X, et al. Evaluation of formocresol ver-
ment of bifurcation radiolucency, pathologic sus ferric sulphate primary molar pulpotomy: A sys-
tematic review and meta-analysis. Int Endod J 2007;
root resorption, dry necrotic pulp, and sinus
40:751–757.
tracts may, by themselves, lead to acceler-
5. Peng L, Ye L, Tan H, Zhou X. Evaluation of the formo-
ated root resorption. Another limitation is
cresol versus mineral trioxide aggregate primary
that relationship between the accelerated molar pulpotomy: A meta-analysis. Oral Surg Oral Med
root resorption and the iodoform-containing Oral Pathol Oral Radiol Endod 2006;102:e40–e44.
root canal filling material could not be 6. Tunison W, Flores-Mir C, El Badrawy H, Nassar U,
established, and the accelerated resorption El-Bialy T. Dental arch space changes following
could be due to the inflammatory process premature loss of primary first molars: A systematic
that was initiated by the irreversible pulpitis. review. Pediatr Dent 2008;30:297–302.
Further studies are needed to investigate 7. Wright FAC, Widmer RP. Pulpal therapy in primary
molar teeth: A retrospective study. J Pedod 1979;3:
the relationship between root canal filling
195–206.
material and the rate of root resorption.
8. Harokopakis-Hajishengallis E. Physiologic root
resorption in primary teeth: Molecular and histo-
logical events. J Oral Sci 2007;49:1–12.
9. Sahara N. Cellular events at the onset of physiologi-
CONCLUSION cal root resorption in rabbit deciduous teeth. Anat
Rec 2001;264:387–396.
10. Roberts JF. Treatment of vital and nonvital primary
3PPU DBOBM USFBUNFOU QFSGPSNFE XJUI JPEP- molar teeth by one-stage formocresol pulpotomy:
form-containing root canal filling material Clinical success and effect upon age exfoliation. Int J
Paediatr Dent 1996;6:111–115.
accelerates root resorption in root canal–
11. Haralabakis NB, Yiagtzis SC, Toutountzakis NM.
treated primary molars compared with
Premature or delayed exfoliation of deciduous teeth
homologous teeth without root canal treat-
and root resorption and formation. Angle Orthod
ment. General dentists and pediatric dentists 1994;64:151–157.
who follow the guidelines of the American 12. Barr ES, Flatiz CM, Hicks MJ. A retrospective radio-
Academy of Pediatric Dentistry and perform graphic evaluation of primary molar pulpectomies.
root canal treatments in primary molars Pediatr Dent 1991;13:4–9.
using iodoform-containing root canal filling 13. Van Amerongen WE, Mulder GR, Vingerling PA. Con-
material should be aware that the treated sequences of endodontic treatment in primary teeth.
teeth will probably shed before homologous Part I: A clinical and radiographic study of the influence
of formocresol pulpotomy on the life-span of primary
ones that are not endodontically treated.
molars. ASDC J Dent Child 1986;53:364–370.
14. Bolan M, Rocha MG. Histopathologic study of physi-
ological and pathological resorptions in human
primary teeth. Oral Surg Oral Med Oral Pathol Oral
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