DRUG ANALYSIS

GROUP :12-A YEAR AND SECTION: 4-DCN

GENERIC NAME: Hydralazine BRAND NAME:Apresoline PREGNANCY CATEGORY: C

ROUTE OF ADMINISTRATION: Oral, IV, IM AVAILABLE STOCK: injection: 20mg/ml; tab: 10mg, 25mg, 50mg, 100mg

DOSAGE: IM/ IV: 10-40mg, repeat PRN; PO: 0.1-0.2 mg/kg/dose

DRUG MODE/ INDICATIONS / ADVERSE DRUG NURSING HEALTH

CLASSIFIC MECHANISM OF CONTRAINDICATIO REACTIONS TO INTERACTIONS CONSIDERATI TEACHING
ATION ACTION NS WATCH OUT FOR ON
• Directly Indications • Headache • Indomethacin • Monitor • Instruct
Antihypert relaxes • Dizziness - may patient’s patient to
ensive, arteriolar Combination • Tachycard decrease blood take oral
Vasodilato smooth therapy in ia effects of pressure, form with
r muscles hypertensio • Angina hydralazine pulse meals to
to cause n and in pectoris • Metoprolol, rate, and increase
vasodilati chronic • Palpitatio propanolol- body absorption.
on and CHF. ns may increase weight • Inform
decreased Preeclampsi levels and frequently patient
• Nausea
blood a, effects of the . that low
• Vomiting
pressure. eclampsia, beta blockers • Elderly blood
• Diarrhea
heart • Diuretics, patients pressure
• Anorexia may be
failure other and
• Neutrope more dizziness
nia hypotensive
Contraindication drugs- may sensitive upon
• Leukopini to drug’s standing
cause
a hypotensi can be
Patients excessive
• rash hypotension. ve effects minimize
hypertensiv
e to drug. • Monitor by rising
Those with patient slowly and
• Diazoxide.
coronary closely for avoiding
MAO
artery signs and sudden
inhibitors-
disease or symptoms position
may cause
mitral of lupus- changes.
severe
valvular like • Take as
hypotension.
 syndrome. directed.
rheumatic • Don’t • Avoid
heart confuse alcohol.
disease. with • Weigh daily
hydroxyzi at the
ne or same time,
apresoline in the
with same
apresazin clothes for
e. the first 2
weeks and
weekly
thereafter.
• Report
weight gain
>5 lb/week
or swelling
of feet or
ankles

• Report
chest pain,
rapid
heartbeat,
or
palpitations
; flu-like
symptoms;
respiratory
difficulty;
skin rash;
numbness
and
tingling of
extremities
; muscle
cramps,
weakness,
or tremors;
persistent
GI
problems;
or other
 adverse
reactions.

DRUG ANALYSIS
GROUP: 12-A YEAR AND SECTION: 4-DCN

GENERIC NAME: Oxytocin BRAND NAME: Syntocinon ROUTE OF ADMINISTRATION: IV

PREGNANCY CATEGORY: X AVAILABLE STOCK: injection: 10 units/ml DOSAGE: I.V.: 10-40 units by I.V.
infusion in 1000 mL of intravenous fluid at a rate sufficient to control uterine atony

DRUG MODE/ INDICATIONS / ADVERSE DRUG INTERACTIONS NURSING HEALTH

CLASSIFICA MECHANI CONTRAINDICATION REACTIONS TO CONSIDERATIO TEACHING
TION SM OF S WATCH OUT FOR N
ACTION
Uterine- Acts on Indication • nausea • Sympathomimet • Monitor • Drug is
active smooth and ic amines- a
agents muscle of and
Induction of labor vomiting severe uterine
the at term; • cramping hypertension record stimulan
uterus to control of • stomach and possible uterine t. It
stimulate postpartum pain stroke works
contracti
contracti bleeding; • headache by
ons; adjunctive ons, causing
• dizziness • Vasoconstrictors
response therapy in / Caudal block heart uterine
depends manageme anesthesia- rate, BP, contract
on the nt of severe ions by
uterine intrauter changin
abortion hypertension
threshold possible ine g
of pressure calcium
excitabilit Contraindication concent
,
y. Is • patients rations
selective fetal in the
hypersensiti
for the heart uterine
uterus, ve
rate, and muscles
especially to the drug .
toward blood
or any of • Cramps
the end loss q15. will feel
its
of • Be alert like
pregnanc component. strong
for
y, during • cephalopelvi menstru
labor, adverse ational
c
and reaction cramps
immediat disproportion
• Monitor but will
ely or continue
following I/O. to
delivery that
delivery. Antidiure increase
requires
Oxytocin, tic effect in
stimulate conversion, intensity
s may
as in . Report
rhythmic lead to increase
tranverse lie;
contracti fluid blood/
ons of in fetal
overload fluid
the distress loss,
uterus, , severe
when
increases seizures, headach
the delivery
and es,
frequenc isn’t fever,
y of coma foul
imminent; in
existing • never smelling
contracti prematurity give drainag
ons, and e or
raises the and in oxytocin ever
tone of severe simultan abdomin
uterine toxemia, eously al
musculat cramps.
hypertonic by more
ure.
uterine than one
• Review
patterns, route. potentia
total • have l
placenta 20% adverse
effects
previa or solution associat
vasa previa. magnesi ed with
• fetal distress um the
therapy.
sulfate
available
for
relaxatio
n
of the
myometr
ium.
• If
contracti
ons are
less
than 2
minutes
apart, if
they’re
above
50mm
Hg
,or if
they last
90secon
ds
or
longer,
stop
infusion,
and turn
patient
on her
side, and
notify
prescrib
er
 DRUG ANALYSIS
GROUP :12-A YEAR AND SECTION: 4-DCN

GENERIC NAME: Magnesium Sulfate BRAND NAME: Epsom Salts PREGNANCY CATEGORY: A

ROUTE OF ADMINISTRATION: IV, IM AVAILABLE STOCK: injection: 4% (0.325 mEq/ mL, 8% (0.65 mEq/mL), 12.5% ( 1
mEq/ mL), 50%( 4mEq/ mL)

DOSAGE: I.M.: 1-4 g every 4 hours I.V.: Initial: 4 g, then switch to I.M. or 1- 4 g/hour by continuous infusion

DRUG MODE/ INDICATIONS / ADVERSE DRUG NURSING HEALTH

CLASSIFIC MECHANISM OF CONTRAINDICATIO REACTIONS TO INTERACTIONS CONSIDERATI TEACHING
ATION ACTION NS WATCH OUT FOR ON
Magnesium Indication • Drowsines • CNS • Assess • Do not
Anticonvul Sulfate depressant(g exceed
sant, s pt.’s
↓ Control eneral prescribed
miscellan seizures in • depressed anesthetics, conditi dose.
may decrease
eous; and preeclamps reflexes, sedative- on • Ensure
laxative, acetylcholine
ia and flaccid hypnotics, before well-
saline released by narcotics) –
eclampsia balanced
nerve To manage paralysis Additive CNS therap diet, with
impulses preterm • hypother depression y and increased
↓ labor mia • Neuromuscul regular bulk,
but ar blocking increased
• hypotensi ly
anticonvulsant Contraindication agents- water
on possible thereaf intake, and
mechanism is
• flushing potential of ter to regular
unknown. In the presence of
• circulator neuromuscul monito daily
↓ heart block
ar blockade exercise to
or y r the
Control seizures • Streptomycin promote
myocardial
collapsed, - decreases drug’s bowel
damage. In
decreased streptomycin effectiv motility.
toxemia of
pregnancy antibiotic
cardiac eness.
during the activity • Report
function • Tetracycline- • BP adverse
2 hour prior
to delivery. and heat Decreases monito side effects
block. tetracycline ring, or lack of
• Hypoglyc antibiotic and
activity response.
emia hold if
• Respirator BP is
y <80/60
paralysis • withhol
• diaphore d if
sis urine
output
is <30
cc/hour
• withhol
d if
respira
tion
<12
cpm
• Keep
I.V.
calciu
m
glucon
ate at
all
times
to
reverse
magne
sium
intoxic
ation.
(↓ RR,
↓ BP,
↓ UO
 DRUG ANALYSIS
GROUP: 12-A YEAR AND SECTION: 4-DCN

GENERIC NAME: Methylergonovine maleate BRAND NAME: Methergine ROUTE OF

ADMINISTRATION: IV

PREGNANCY CATEGORY: C AVAILABLE STOCK: injection: 0.2 mg/ml; tab: 0.2 mg

DOSAGE: IV: 0.2 mg after delivery of anterior shoulder, after delivery of placenta, or during puerperium; may be repeated as
required at intervals of 2-4 hour

DRUG MODE/ INDICATIONS / ADVERSE DRUG INTERACTIONS NURSING HEALTH

CLASSIFIC MECHANIS CONTRAINDICAT REACTIONS TO CONSIDERATI TEACHING
ATION M OF IONS WATCH OUT FOR ON
ACTION
Oxytocic Methergin Indication • Hypertensio • Azole • Be alert • Take only
drug e n associated antifungals- as
for
↓ Prevention and with seizure increases risk of directed;
or headache vasospasm adverse do not
Stimulates treatment of
postpartum and • Nausea and leading to reactio exceed
uterine
vomiting cerebral ns and dosage.
smooth postabortion
• Diarrhea ischemia and/or • Avoid
muscles hemorrhage ischemia of the drug smoking;
• Foul taste
↓ caused by extremities; do interact nicotine
• Dizziness
producing uterine not use together ions. constricts
• Tinnitus
sustained atony or • Erythromycin- blood
• This
contractio subinvolution increases risk of vessels.
vasospasm drug • Report
ns
leading to should any S&S
↓ cerebra ischemia be of
thereby and/ r ischemia ergotism
shortens Contraindicati of the used (cold/
the third on extremities extrem numb
stage of • Sympathomimeti ely fingers/toe
• In
labor cs- hypertension s, nausea
patients carefull
related to and
hypersen additive y vomiting,
vasoconstriction becaus headache,
sitive to
e of it's muscle or
methyler chest
gonovine potent pain,
or vasoco weakness)
nstricto or
any infection.
compone r
nt of the action.
• Abdominal
formulati I.V. use cramps
may may be
on.
experienc
• ergot induce
ed, report
alkaloids sudden any
are hyperte severe
nsion cramping,
contraind increase
icated and bleeding,
with cerebro or other
vascula adverse
potent effects.
r
inhibitors acciden
of ts. As a Follow up
with
CYP3A4 last provider
(includes resort, to ensure
protease give no
complicati
inhibitors I.V. ons.
, slowly
azole over
antifung several
als, and minute
some s
macrolid and
e monitor
antibiotic blood
s); pressur
hyperten e
sion; closely
toxemia;
pregnanc
y
 DRUG ANALYSIS
GROUP: 12-A YEAR AND SECTION: 4-DCN

GENERIC NAME: Hyoscine butylbromide BRAND NAME: Buscopan ROUTE OF ADMINISTRATION: Oral

PREGNANCY CATEGORY: C AVAILABLE STOCK: 10mg DOSAGE: 10mg 3 times daily/ Adult 1-2 tabs TID. Max: 6
tabs/day

DRUG CLASSIFICATION MODE/ INDICATIONS / ADVERSE DRUG NURSING HEALTH

MECHANI CONTRAINDICATI REACTIONS TO INTERACTIONS CONSIDERA TEACHING
SM OF ONS WATCH OUT FOR TION
ACTION
 Inhibits Indication • constipatio • Additive • Urge
Gastro/ muscarini sedative patie
Antispasmodics/Antich n effects with
c actions used to relieve nt to
olinergics.
of bladder • dry mouth alcohol or
repor
or • photophobi other CNS
acetylchol t
intestina depressants.
ine on a urina
l spasms. • antidepressa
autonomi Paroxysmal • flushing ry
nts (tricyclic
c pain in • skin rash type) hesit
effectors diseases ancy
• urinary • MAO
innervate of Inhibitors or
d by stomach urgency
(e.g., urine
postgangl & and urinary phenelzine, reten
intestine linezolid,
ionic retention. tion.
. Spastic tranylcyprom
cholinergi pain & • Confusion
c ine,
function • nausea, isocarboxazi
neurons. al
vomiting d, selegiline,
May disorder furazolidone)
effect s in and
,
neural biliary & dizziness.
urinary • quinidine,
pathways • amantadine
tracts,
originatin female • antihistamine
g in the genital s (e.g.,
inner ear organs diphenhydra
to inhibit e.g. mine)
dysmeno
nausea • anticholiner
rrhea.
and gics
vomiting. • potassium
Contraindicatio chloride
n supplements
• Glaucoma • antacids,
• myastheni absorbent-
type
a gravis antidiarrhea
• paralytic medicines
ileus (e.g., kaolin-
pectin).
• pyloric
stenosis
• prostatic
 enlargem
ent
• porphyria