Medical Laboratory Technicians PDF

Study Program: MEDICAL LABORATORY TECHNICIANS
FIRST YEAR - I SEMESTER

Code COURSE Credits Hours Overall workload
3MF100212 Anatomy 7 3+3+1 210
Introduction to human genetics 5 2+2+1 150
Histology and Embryology 6 2+3+1 180
Communication skills 6 2+3+1 180
Clinical phychology 2 1+1+1 60
Foreign language 1 – English
Foreign language 1 – Italian 4 0+0+4 120
Foreign language 1 – German
UGD100112
Foreign language 1 – French
Foreign language 1 – Spanish
Foreign language 1 – Russian
UGD102712 Sports and recreation* 0 0+0+2

0
FIRST YEAR - II SEMESTER

Physiology 4 2+1+1 120
Biochemistry 4 2+1+1 120
Microbiology and Parasitology 6 2+3+1 180
Nursing care 6 2+3+1 180
Ecology and Hygiene 2 2+0+1 60
Epidemiology 4 2+1+1 120
Computer Science 4 2+1+1 120
SECOND YEAR – III SEMESTER
Pathophysiology 6 2+3+1 180
Pathology 6 2+3+1 180
Pharmacology 4 2+1+1 120
Introduction to internal medicine 6 3+2+1 180
Immunology 3 1+1+1 90
Cell biochemistry 5 2+2+1 150
SECOND YEAR - IV SEMESTER

Good laboratory practice 5 2+2+1 150
Analytical chemistry 5 2+2+1 150
Introduction to transfusiology 5 2+2+1 150
Medical histology 4 2+1+1 120
Biostatistics 4 2+1+1 120
Instrumental analysis 5 2+2+1 150
Elective course group 1 2 2+0+1 60
THIRD YEAR – V SEMESTER
Introduction to clinical practice 5 2+1+1 150
Introduction to infectious diseases 5 2+2+1 150
Clinical and toxicological analyses 6 3+2+1 180
Bromatology 6 3+2+1 180
Laboratory safety 4 2+1+1 120

THIRD YEAR - IV SEMESTER
Clinical microbiology 4 1+2+1 120
Clinical biochemistry 6 3+2+1 180
Clinical tranfusiology 4 1+2+1 120
Professional practice 4 0+4+0 120
Bachelor thesis 8 240
LIST OF ELECTIVE COURSES

SECOND YEAR – IV SEMESTER (Group 1)
Nutritionism-modelling and 2 2+0+1 60
optimization
Public health 2 2+0+1 60
Intrahospital infections 2 2+0+1 60
SECOND YEAR –V SEMESTER (Group 2)

Virusology 4 2+1+1 120
Methodology of scientific research 4 2+1+1 120

in Health Care
Nuclear medicine 4 2+1+1 120
THIRD YEAR- VI SEMESTER (Group 3)

Citological analysis in early 4 2+1+1 120
diagnostics of malignant diseases
Immunological laboratory 4 2+1+1 120
techniques
Evaluation of instruments, methods 4 2+1+1 120
and reagents
COURSE PROGRAMME INFORMATION IN ACCORDANCE WITH ARTICLE 4 FROM
THE REGULATIONS BOOK FOR COMPULSORY COMPONENTS OF THE COURSE
PROGRAMMES FROM THE FIRST, SECOND AND THIRD CYCLE STUDIES
Annex No.3 Course Programme- first/second/third cycle studies
1. Course title Anatomy
2. Code
3. Study programme Medical laboratory technicians
4. Organizer of the study programme(unit or Faculty of Medical Sciences

institute, faculty, department)
University "Goce Delchev" Stip
5. Level of studies (first, second and third First cycle

cycle)
6. Academic year / semester First 7. Number of 7

credits
8. Lecturer/ Instructor Prof. Svetlana Jovevska PhD
9. Required prerequisite courses
10. Course objectives (competencies):
Introduction to anatomy as morphological science, mastering of professional

terminology, complete study of the locomotion system extremities.Introduction to the
anatomy of the chest, abdomen and pelvis, and skeletotopical and holotopical ratios in
these physical bodies gaps.
11. Course content:
Theoretical instruction
1. Introduction to osteology and anatomy, types of bones, bone components, technical

terminology. Bones of fixed and movable part of the upper limb bones of fixed and
movable part of the lower limb, chest bone and body.
2. Introduction to sindezmology, wrist, components of the joint, types of joints.
Syndezmology of the upper limb, Syndezmology of the trunk and lower limb
3. Miology, Angiology and Neurology of the upper limb. Miology, Angiology and
Neurology of the lower limb.
4. Orientacion of bone fracture, spatula, upper arm, forearm bones (radius and ulna)
Idowu chest, breast structure, the system of organs for breathing, cardiovascular
organs. Abdominal wall muscle, vasculature, innervation, ratios.
5.Organs in the abdominal cavity-peritoneum, esophagus, stomach, organs in the
abdominal cavity-small and large intestine, liver, bile tract, pancreas
6.Spleen, kidney, adrenal gland, urinary tract, pelvic cavity-limits and construction;
urinary organs, female sex organs, male sex organs
7. Arteries of the head and neck, veins and lymph vessels in the head and neck
8. Cranial nerves-number nomenclature, proportions, cranial nerve-inervation areas
9.Organs in the head and neck-topography ratios, endocrine glands.
10. Organs of the digestive system in head and neck organs of the respiratory system
in head and neck.
11. Sensory organs, eye and ear, nervous system, construction, types of nerve fibers
division of the nervous system, ventricular system
12. Spinal cord, rombest brain, midbrain, membranes of the brain.
Practical instruction
1.Orientation of bone fracture, spatula, upper arm, forearm bones (radius and ulna)
Skeleton of hand: (bunch of hand), hands bones and bones of the fingers, chest and
spine, joints of the lower limb, Gaza pelvic-bone, joints of coxae and sacrum bone
skeleton of above the knee-femora, and shin-bones of tibia, fibula, patelae.
2. Skelet foot-bones of the foothill, knee and toes, joints of the upper extremity, chest
and spine, lower extremity joints, muscles, and blood vessels of the upper limb.
3. Muscles and blood vessels of the lower limb, innervation of upper and lower
extremity, chest-wall construction, division of mediastinum, borders, composition,
topography, Mediastinal organizational relationships; structure and topography of the
respiratory system.
4. Anatomy of the system for blood-heart and major blood vessels, and topography
ratios, abdominal wall-building: muscle ratios of muscle organs, vasculature and
innervation, orientation in the abdominal cavity-peritoneum, esophagus, stomach, and
topography ratios.
5.Topography of the organs in the abdominal cavity-structure and orientation of the
small and large intestine, orientation models of liver, bile tract, pancreas, orientation
models of spleen, kidney, adrenal gland, urinary tract anatomy.
6.Pelvic wall construction, topographic relationships of organs, pelvic organs, pelvic
cavity-urines authorities, relations with other organs, vascularization and innervation,
female genital-orientation, relations with other organs, male sex organs-orientation,
relations with other authorities.
7. Vasculature of the head and neck, venous, lymphatic system of the head and neck
8. Spinal nerves, mouth
9. Organs of the digestive system located in the head and neck, respiratory organs
situated in the head and neck.
10. Nasal cavity-anatomical parts, structure, function, endocrine glands-topography
ratios.
11. Eye-anatomy, proportion, anatomy of the orbit, ear-anatomy, relationships with
other agencies.
12. Senses of taste, smell, touch and balance, autonomic nervous system-anatomical
division function.
12. Course methodology:Interactive classes, individual consultations with students
13. Total available time 7 ECTS х 30 hours = 210 hours
14. Distribution of available time 45+45+15+ 15+90
15. Forms of teaching activities 15.1. lectures / theoretical 45 hours

teaching,
e-teaching
15.2. theoretical and practical 45 hours

exercises,
e-exams, seminars, team

work
16. Other forms of activities 16.1. Project work 15 hours
16.2. Individual work 15 hours
16.3. Homework 90 hours
17. Assessment method
17.1. Tests / oral exams 70 points
17.2. Seminar paper / project (presentation: written and/or 10 points

oral)
17.3. Attendance and participation 20 points
18. Grading system (points / grade) up 50 points 5 (five) (F)
51 to 60 points 6 (six) (E)
61 to 70 points 7 (seven) (D)
71 to 80 points 8 (eight) (C)
81 to 90 points 9 (nine) (B)
91 to 100 points 10 (ten) (A)
19. Signature and final exam Attendance- at least 7 (60%) continuous checks
prerequisites at lectures and 10 tutorials, for final exam scored
42 points and passed continuous checks.
20. Language of instruction Macedonian language
21. Method of monitoring the quality of Self-evaluation

instruction
22. Literature
Required literature
No. Author Title Publisher Year
1. Prof.dr.Shumanov et al. Anatomy of man-script educational

work
22.1. 2. A. Kargovska-Klisarova, Anatomy of man- educational

N.. Djordjevic, D.. Osteologija work
Lazarova
3. A. Kargovska-Klisarova Anatomy of human-arm

A. Kargovska- and chest
Klisarova Anatomy of man-Foot
A.Kargovska-Klisarova, Anatomy of man-
MD. Dzhidrova, A. Abdomen
Strateska-Zafiroska Anatomy of man-Pelvis
N.. Christ-Djordjevic, A..
Kargovska-Klisarova
Supplementary literature
1. Sinelnikov Anatomical Atlas of

22.2. man (I, II, III part)
2. F.N. Netter Atlas of human

anatomy
3.
1. Course title Introduction to human genetics
2. Code
4. Organizer of the study Faculty of Medical Sciences

programme(unit or institute,
faculty, department)
5. Level of studies (first, second and First cycle

third cycle)
6. Academic year / semester first 7. Number of 5

credits
8. Lecturer/ Instructor Prof. Darko Bosnakovski
10. Course objectives(competencies):
Introduction to basic scientific knowledge of cell biology and genetics.
11. Course content:

1. Morphology and physiology of the cell.
2. DNA, iRNK, rRNK, tRNA,
3. Transcription, translation, replication of the DNA.

4. Inheritance of properties-principles, gene interaction; Genes- structure and function
genome, genotype, genetic code, alleles, and gene expression.
5. Structure and function of the chromosome. Mitosis and meiosis.
6. Autosomal, recessive inheritance, X linked inheritance, intermediate and

codominant inheritance.
7. Numerical chromosomal aberrations: aneuploidy, heteroploidy, monosomy,
nullisomy, trisomy.
8. Structural aberration: deletions, duplications, translocations, inversions.
9. Mutations. Mutagenic factors.
10. Autosomal and X-linked genetic diseases.
11. Genetic basis of malignancy (cancer).
12. Genetic engineering.
12. Course methodology:Lectures,exercises, seminar paper and practical activities
13. Total available time 5 ECTS х 30 hours =150
14. Distribution of available time 30+30+15+15+60

teaching,
e-teaching

exercises,

work

oral)

19. Signature and final exam 42 points acquired

prerequisites
20. Language of instruction Macedonian

instruction
22. Literature
Required literature
1. Нада Митева Општа Биологија UKIM 2000

(цитологија, генетика,
(Nada Miteva)
ембриологија)
22.1.
2. Мирјана Ќаева Медицинска генетика UGD 2008
Пејковска
( medical genetics)
(Marija Kaeva
Pejkovska)
3.

22.2.
1. Essentials of Genetics Klug, Cummings and Benjamin 2012
Spencer Cummings
1. Course title Histology and Embryology
2. Code


third cycle)
6. Academic year / semester First semester 7. Number of 6

credits
8. Lecturer/ Instructor Assistant professor Nevenka Velickova PhD
9. Required prerequisite courses Enrolled first year of studies
10. Course objectives (competencies): Introducing the histological structure, structure and
function of all types of tissues, organs and organ systems in man.
11. Course content:
 Epithelial tissues
 Connective tissue
 Muscle tissue
 Nervous tissue
 Gastrointestinal system
 RES
 Respiratory system. urogenital system
 Nervous system. Endocrine system
 Spermatogenesis and oogenesis
 Embryonic development
 Organogenesis
 Placentation
 Making permanent histological preparations

 Epithelial tissues
 Conective tissue
 Muscle tissue
 Nervous tissue
 Gastrointestinal system
 Glands in the gastrointestinal system
 RES
 Respiratory system. urogenital system
 Nervous system. Endocrine system
 Spermatogenesis and oogeneza
12. Course methodology: Lectures,exercises,seminar paper and practical activities
13. Total available time 6 ECTS + 30 hours = 180 hours

teaching,
e-teaching

exercises,

work


oral)

prerequisites

instruction
22. Literature
Required literature
1. Луис Карлос Основи на Табернакул 2010

Жунквеира, Хосе хистологијата
22.1.
Карнеиро
2. Хистологија со Нада Митева

ембриологија
3. Хистологија со Невена Костовска,

ембриологија Лилјана Миленкова

22.2.
1. Danica Roganivik - Cytology
Zafirova
1. Course title Communication skills
2. Code


third cycle)

credits
8. Lecturer/ Instructor Assistant professor Gordana Panova
9. Required prerequisite courses Enrolled in first year
10. Course objectives (competencies): Knowledge and understanding of basic

communication rules and the individual needs to communicate with other people
- Organizing an active and independent learning communication skills and preparing

students for effective learning basic communication skills
- Training for establishing effective communication between staff health workers,

patients and their relatives and friends, as well as the formation of feedback information
for successful communication, with special emphasis on health communication.
- Communication advantages, cooperation and teamwork with the University and in

health care facilities
11. Course content:
Communication (definition, verbal and nonverbal communication styles). Importance of

non-verbal communication, body language (posture, eye contact, pitch, and loudness,
adequate mimics, personal space ...). Ability to hear, barriers for good communication,
negotiation, communication between healthcare professionals (code of conduct,
speech, dress, etc.) Communication between patient- doctor, patient-nurse, health
worker (problematic reactions, adequate reactions), Tech Troubleshooting and
relaxation techniques, Burn Out (definition, cause, solution), aggressive communication
style, passive communication style.Communication between health workers in all
health institutions, outpatient clinics, hospitals, clinics, sanatoriums.
12. Course methodology:lecture, exercises, consultations
13. Total available time 6ECTS + 30 hours = 180 hours

teaching,
e-teaching

exercises,

work

oral)

19. Signature and final exam Passed two colloquia, attendance and
prerequisites presentiation of project assignment, and
acquired at least 42 points.

instruction
Written and oral presentation of the learning
content,practical examples from hospitals
22. Literature
Required literature
1. Doc.dr.G.Panova Communication skills UGD-Stip 2010
22.1.
2. K.R.Seturman Communication skills in Tabernakul 2010
clinical practice
3. Hilde and Tom Eide, Communication Udruzhenje 2006

med.sesti
Belgrade
22.2. 1. Marcia Lewis Carroll Tamparo Medical Tabernakul- 2010

Law, Ethics and Skopje
Bioethics Academic
Press,
2. Marich John Medical Communication skills Faculty of 2005
in clinical practice Medicine,
Belgrade,
3. R.C.Petterson Based Learning Biokonto Igalo 2008
problems
Annex Course Programme - first, second and third cycle of study
No.3
1. Course title Clinical psychology
2. Code

programme (unit/ institute,
department)
5. Level of study (first, second, third First cycle
cycle)
6. Academic year / semester First Academic 7. Number of 2
year ECTS credits
first semester
(1+1+1)
8. Lecturer/ Instructor Prof. Lence MIloseva, Ph.D
-To become familiar with basic concepts and tasks of clinical psychology and health
psychology and their applicability in medical settings.
-To gain knowledge and understanding of the concepts, structure, psychological

processes and personality changes through different developmental periods.
- Introduction to basic principles of psychological approach, preparation and
implementation of psychological interventions with patients and/or inpatients;
knowledge and understanding of human behavior in medical settings, the person’s
reactions to illness.
-To become familiar with biopsychosocial model of health, psychological aspects of

somatic diseases, and some of the most common mental disorders; assessment of
different approaches to diagnosis and treatment and understanding of the link of these
different approaches to their potential impact on patients.
-To gain knowledge and methods for maintaining an promoting mental health and well
being .
-To develop communication skills (doctor/patient).
11. Course content:
General part
 Introduction to Medical Psychology as a science (Clinical and Health

psychology in medical settings).Biopsychosocial model of health and
illness.
 Human development. Child and adolescent psychology. Psychology of

adulthood and aging.
 Psychology of patients (Psychological aspects of hospitalization. Child as a

patient. Adult as a patient. Geriatric patients. Psychological preparation for
medical examinations and surgery interventions; intensive care).
 Psychology of pain (Psychological aspects of pain and methods of coping).
 Communication in medical settings.
Special part
 Stress and coping.
 Mental health and mental disorders.
 Psychoneuroimmunology, AIDS and cancer; Psycho-oncology;
Psychological aspects of chronic and terminal illness.
 Psychosomatic illness; Psychological aspects of cardiovascular

disease; brain injury; Brain stroke; Psychological aspects in prevention
of somatic illness; Psychological aspects of pregnancy.
 Death and dying.
 Positive health psychology.
 Health promotion. Family, health and illness.
12. Course methodology:

seminars, interactive method: group work, reports, homework, seminar papers,
discussion, debate, cooperative studying techniques, individual work, simulation of
extra-curricular educational activities, individual studying
13. Total amount of available time: 2ECTS х 30 hours = 60 hours

14. Distribution of available time: 15+15+15+5+10
15. Forms of teaching activities 15.1. Lectures- theoretical 15 hours
classes
15.2. Practice(laboratory, 15 hours
theoretical) seminars, team
work

17.1. Tests 70
17.2. Seminar paper/project (presentation: oral and written)
17.3. Attendance and participation
17.4. Oral exam
18. Grading system(points /grade) to 50 points 5 (F)
from 51 to 60 points 6 (E)
from 61 to 70points 7 (D)
from 71to 80 points 8 (C)
from 81to 90 points 9 (B)
from 91 to 100 points 10 (A)
19. Signature and final exam 60% success from all pre-exam activities or 42
prerequisites points from the mid-term tests and the seminar
paper as well as attendance and participation in
class
instruction
22. Literature:
Required literature
22.1.
Ordinal Author Title Publisher Year
numbe
r
1. Милошева, Л. Клиничка психологија УГД, 2013
– курс на е-учење, Факултет
УГД, Факултет за за
медицински науки медицинск
и науки
2. Berger, J, & Mitic, M. Uvod u kliničku Beograd: 2002
psihologiju Primenjena
psihologija
3. Милошева, Л. Развојна психологија Штип: УГД 2013
4. Havelka, M. Zdravstvena psihologija Jastrebarsk 2002

o:Naklada
Slap
numbe
r
1. Nietzel,M.T., Uvod u kliničku Jastrebarsko: 2002
Bernstein, D.A. & psihologiju Naklada Slap
Milich, R.
2. Michie S. Abraham C. Health Psychology in Oxford: BPS 2004
22.2. Practice Blackwell
Publishing
3. Marks, D.F., Murray, Health psychology: London: 2011
M., & Evans, B. Theory, research, and SAGE
practice
Annex No.3 Course Programme- first cycle studies
1. Course title Foreign Language1 (English 1)
2. Code UGD100112

program(unit or institute, faculty,
department)

third cycle)
6. Academic year / semester first semester 7. Number of credits 4
8. Lecturer/ Instructor Prof. Biljana Ivanovska, PhD Prof. Tole Belčev and
Senio Lecturer MA Snezhana Kirova
9. Required prerequisite courses Enrolled first year
10. Course objectives (competencies): The aim ofthe course is to enable students to supplement
and expand their language skills and to use them in specific situations, verbal
communications in medicine through the integrated use of linguistic feature sof discourse.
11. Course content:
Medical texts are organized according to the classification of human body systems.Practicing
pronunciation medical terms, translation of certain terms and phrases, lexical exercises for
presentation and evaluation of medical terminology,exercise sto prepare students to be
informed,selective and analytical reading through deductive and inductive conclusion, training
students for self-direction,writing a short dialogue, summaries, opinions or short articles on a
given topic.
12. Course methodology: seminars, interactive method: group work, lectures, homework, papers,
discussion, debate, cooperative learning techniques, Individual work, simulation of
extracurricular educational activities, independent learning.

15. Forms of teaching activities 15.1. lectures - theoretical teaching
15.2. Practice (laboratory,theoretical),

seminars, teamwork
17.1. Tests 70 points
17.2. Seminar paper/project (presentation: written and/or oral) 10 points
18. Grading system (points /grade)
up 50 points 5
19. 51 to60 points 6
61 to70 points 7
71 to 80 points 8
81 to90points 9
91 to100 points 10
60% of the success of the pre-

test activities, and 42 points
Signature and final exam
from two colloquia, seminar
prerequisites
paper, attendance at lectures
and exercises
20. Language of instruction English

instruction
2. Literature
Required literature

22.1.
1. Pandora Dimovska Englishfor UKIM 2000,
medicalanddental Skopje
1. Course title Foreign Language1 (Italian language 1)
2. Code UGD100212


third cycle)
6. Academic year / semester first semester 7. Number of 4

credits
8. Lecturer/ Instructor Assistant Professor Biljana Ivanovska
Professor Tole Belcev
Senior Lecturer Snezana Kirova

Students are to get acquainted with the basic notions of essential Italian vocabulary
used in situation from the everyday life; develop ability to ask and to give information,
to greet, to introduce themselves, to describe the environment where they live and act,
to describe a person’s physical appearance, to speak about their habits and interests,
to communicate on the telephone, to order in a restaurant, to narrate events in the past
etc. Introduction to basic vocabulary, reading, listening, speaking and writing skills
practice. Acquisition of reading and writing skills and basic grammatical word classes:
definite and indefinite article, gender and number of the nouns and adjectives,
descriptive, possessive, demonstrative, interrogative; subject pronouns, numerals,
present tense, prepositions, adverbs of place, etc.
11. Course content:

1. The alphabet, pronunciation, noun, personal information, greetings and farewells
2. Adjectives, personal pronouns, nationality
3. Definite articles
4. The verbs "to have" and "to be”
5. Present simple tense: regular verbs; formal, polite form
6. Writing letters, talking on the phone, requesting and providing information
7. Describing physical appearance, regions and cities in Italy
8. Present simple tense: irregular verbs
9. Leisure activities; describing the environment
10. Modal verbs, numbers, days of the week, telling time
11. Uses of the prepositions, expressing uncertainty, gratitude, indicating possession
12. Uses of the adverbs of place; possessive adjectives
12. Course methodology:Interactive exercises, group work, essays, homework, seminar

paper, discussion, debate, lectures, techniques of cooperative learning, individual
exercises, simulation of extracurricular educational activities, self-directed learning, use
of e-learning in lectures and practical exercises.
15. Forms of teaching activities 15.1. lectures / theoretical

teaching,
e-teaching
15.2. theoretical and practical

exercises,

work

oral)
class
20. Language of instruction Macedonian and Italian language

instruction
22. Literature
Required literature
22.1.
1. MARIN,T. & Progetto italiano Edilingua
MAGNELLI,S 1(Libro dello studente)
2. MARIN,T. & Progetto italiano 1 Edilingua

MAGNELLI,S (Quaderno degli
esercizi)
3.
22.2. 1.
2.
3.
Annex Course Programme - first cycle of studies
No.3
1. Course title Foreign language 1 (German language 1)
2. Code UGD100312
4. Organizer of the study programme Faculty of Medical Sciences

(unit/ institute, department)
5. Level of studies (first, second, First cycle

third cycle)
6. Academic year / semester First semester 7. Number of 6
ECTS credits
8. Lecturer/ Instructor Biljana Ivanovska PhD, Marica Tasevska
10. Course objectives (competences): Development of the written and spoken competence
and acquiring the modern and current events in the German-speaking countries.
11. Course content:
Basic German vocabulary, reading, listening, speaking and writing.
Seminars, interactive method: group work, papers, homework, seminar paper,
discussion, debate, techniques of cooperative learning, Individual work, simulation of
extracurricular educational activities, independent learning.
13. Total amount of available time: 4 ECTS х 30 hours = 120 hours
15. Forms of teaching activities 15.1. Lectures- theoretical
classes
15.2. Practice(laboratory,
theoretical) seminars,
team work

17.1. Tests 60
17.2. Seminar paper/project (presentation: oral and written) 10
17.3. Attendance and participation
17.4. Oral exam 30
18. Grading system(points /grade) to 50 points 5 (five) (F)
from 51 to 60 points 6 (six) (E)
from 61 to 70points 7 (seven) (D)
from 71to 80 points 8 (eight) (C)
from 81to 90 points 9 (nine) (B)
from 91 to 100 points 10 (ten) (A)
class
20. Language of instruction German language, Macedonian language
instruction
22. Literature:
Required literature
numbe
r
1. Susanne Kalender Schritte international Hueber 2006
Petra Klimazyk 1Deutsch als Verlag
Fremdsprache/
2. Dr. Dimitrija Gacov Deutsche Grammatik National Skopje
22.1. University 1995
Library
“NUB
Kliment
Ohridski”
3. Ranka Grceva Grosses Makedonisch- Magor Skopje
Peter Rau Deutsch, Deutsch- 2006
Makedonisches
Woererbuch
numbe
r
1. DUDEN Grammatik der Mannheim/Wi 1995
deutschen Sprache en/Zürich:
Dudenverlag
22.2.
(=Der Duden
in 12 Bänden
Bd. 4).
2. Monika Reimann Grundstufen- Max Hueber Leipzig
Grammatik für Deutsch Verlag 2001 1979
als Fremdsprache
Annex Course Programme – first cycle studies-
No.3
1. Course title Foreign language 1 (French language 1)
2. Course code UGD100412
4. Organizer of the study programme Faculty of Medical Sciences

(unit/ institute, department)
5. Level of studies (first, second, third First cycle

cycle)
6. Academic year / semester First year / first 7. Number of 4

semester ECTS credits
8. Lecturer/Instructor Tole Belchev, Biljana Ivanovska, Snezana Kirova
9. Required prerequisite courses Basic knowledge of French acquired in previous

education
10. Course objectives (competences):
Acquisition of skills for oral and written comprehension and expression in given
situations. Capability for correct formulation of simple statements; Capability for
communication in everyday situations; Knowledge of the most important milestones of
the French civilization.
11. Course contents:
Grammar: Mastering the basic rules of pronunciation (dropping vowels, phonetic

bonding, and adding consonants.) Verb groups and their variations in the formation of
the Present Tense. Common and proper nouns, gender and number of nouns. Definite
and indefinite article, partitive article, article omission, connecting pronouns with
propositions. Personal pronouns, use of long pronominal forms, bonding pronouns with
propositions. Gender and number of adjectives, their place in relation to the noun.
Descriptive, demonstrative, possessive, interrogative, exclamative adjectives. Cardinal
and ordinal numbers. Imperative and conditional forms. Formation of negation. Types of
interrogative sentences.
Vocabulary: Description of personalities, professions, hobbies, food, housing ...
Culture and Civilization of France: regions, holidays, cultural landmarks.
12. Course Methodology:
Seminars, interactive methods: group work, lectures, homework, papers, discussions,

debates, cooperative learning techniques, Individual work, simulation for extracurricular
educational activities, independent study.
13. Total amount of available time: 4 ECTS х 30 hours = 120 hours
15. Forms of teaching activities 15.1. Lectures- theoretical

classes
15.2. Practice(laboratory,
theoretical) seminars,
team work
17.1. Mid-term tests 40
17.2. Seminar paper/project (presentation: oral and written) 10
17.3. Attendance and participation 20
17.4. Oral exam 30
18. Grading system (points /grade) to 50 points 5
from 51 to 60 points 6
from 61 to 70points 7
from 71to 80 points 8

from 81to 90 points 9
from 91 to 100 points 10
19. Signature and final exam Cumulative score of 60% of all required activities
prerequisites (midterm tests, attendance and seminar papers)
20. Language of instruction French and Macedonian
21. Course evaluation Self-evaluation
22. Literature:
Required literature
1. Guy Capelle, Robert Taxi! 1 Méthode de Hachette 2002

Menand français
22.1.
2. Guy Capelle, Robert Taxi! 1 Méthode de Hachette 2002
Menand français. Cahier
d'exercices
1. АТАНАСОВ, Француско - Просветно 1992

22.2. ПОПОСКИ, македонски речник дело
КАЛАЈЛИЕВСКА)
2. ПОПОСКИ, Македонско - Просветно 1992

АТАНАСОВ француски речник дело
Annex No.3
Course Programme- first cycle studies
1. Course title Foreign language 1 (Spanish Language 1)

2. Code
programme (unit or University Goce Delcev
institute, faculty,
department)
5. Level of studies (first, First cycle
second and third cycle)
6. Academic year / semester first semester 7. Number of credits 4
8. Lecturer/ Instructor Prof. Dusko Aleksovski
Prof. Biljana Ivanovska
Prof. Tole Belčev
Senior Lecturer MA Snezana Kirova
9. Required prerequisite none
courses
Ability for oral and written expression and comprehension of simple situations of everyday
life, the ability to transfer content to read simple language and style, the ability of students to
give and seek information, to greet, to communicate by telephone, to discuss the topics of
everyday life, to describe the environment in which they live, to talk about their habits and
interests as well as determining the grammatical structures and contents etc..
11. Course content:
The basic features of the language. Rules for reading and writing. Master the basic
grammatical content: definite and indefinite article, gender and number of nouns, descriptive
adjectives, pointing, possessive, primes. Presentand past tense. Types of sentences. Short
dialogues from everyday life, seasons, writing short and simple compositions containing
studied grammatical structures and terminology.
Seminars, interactive method: group work, lectures, homework, papers, discussion, debate,
cooperative learning techniques, Individual work, simulation for extracurricular educational
activities, independent learning.
15. Forms of teaching 15.1. lectures - theoretical teaching
activities
15.2. Practice(laboratory,theoretical),
seminars, teamwork
17. Assessment method:

Interactive method, group work, lectures, homework, papers, discussion, debate, cooperative
learning techniques, Individual work, simulation extracurricular educational activities, self-
study, etc..
17.2. Seminar paper/project ( presentation: written and/or oral) 10 points
18. Grading system (points up 50 points 5 (five) (F)
/grade) 51 to 60 points 6 (six) (E)
19. Signature and final exam 60% success from pre- exam activities i.e. 42 points from two
prerequisites colloquia, seminar paper, attendance at lectures and tutorials
20. Language of instruction Spanish and Macedonian languages
21. Method of monitoring the Self-evaluation
quality of instruction
22. Literature
Required literature
1. Ramon Sarmiento “Gramatica progresiva ”Colibri”, 1998
22.1. de español para Софија
extranjeros”
2. A. Jarvis, R. Lebredo, F. “Basic Spanish Houghton 2000
Mena-Ayllón Grammar” Mifflin
Company -
USA
3.
1. A. Gonzales Hermoso, “Gramatica de español Madrid. 1999
22.2.
J. R. Cuenot, M. lengua extranjera” Spanija
Sanchez Alfaro
2. Cristina Karpacheva “Manual de español” Sofija 1998
Annex No.3 Course Programme- first/second/third cyclestudies
1. Course title Foreign language 1 (Russian language 1)
2. Code UGD100612

5. Level of studies (first, second First cycle

and third cycle)

credits
8. Lecturer/ Instructor Snezana Kirova, Tole Belcev, Biljana Ivanovska
10. Course objectives (competencies): Ability associated with oral and

written expression and comprehension of simple, everyday situations. The student will
be able to make introductions, to give basic information about him/herself or other
persons, to describe basic activities and to take part in basic everyday dialogues, to
narrate stories, to give and seek information, to greet, to communicate by telephone, to
discuss topics of everyday life, to describe the environment in which they live, to talk
about their habits and interests as well as to learn the grammatical structures and
contents etc..
11. Course content: Basic language features. Reading, writing, spelling rules. Learning the
basic grammatical terms: definite and indefinite articles, gender and number,
descriptive adjectives, demonstrative, possessive adjectives, cardinal numbers.
Present tense and past tense. Accusative case.Types of interrogative and negative
sentences, seasons of the year. Short everyday dialogues and compositions, using the
grammatical structures and terminology they are familiar with.
12. Course methodology: Seminars, interactive methods: group work, essays, homework,
papers, discussions, debate, cooperative learning techniques, individual work,
extracurricular activities, simulations,self-study.
15. Forms of teaching activities 15.1. lectures / theoretical teaching,
e-teaching

exercises,
e-exams, seminars, team work
18. Grading system (points /grade) up 50points 5(five) (F)
51 to 60 points 6(six) (E)

19. Signature and final exam 60 % success from the pre-exam activity and the
prerequisites seminar paper.
20. Language of instruction Macedonian language/ Russian language
21. Method of monitoring the quality Self-evaluation

of instruction
22. Literature
Required literature

22.1.
1. Kathryn Szczepanska Russian – a self- Wiley 2005
teaching guide
22.2. 2. Kathryn Szczepanska Russian – a self- Wiley 2005

teaching guide
1. Course title Sports and recreation

2. Code UGD102712

programme(unit or institute, faculty,
department)
third cycle)
credits
8. Lecturer/ Instructor Associate Prof. Biljana Popeska, PhD
Fulfillment of students’ needs for movement and physical activity. Maintenance and development
of students’ motor abilities.
11. Course content:
1.Basic physical preparation (introduction to fundaments and basic principles of physical activity,
exercise for strengthening of certain muscle groups)
2. Basic physical preparation (introduction to and application of different forms of warming,
exercises for strengthening of certain muscle groups)
3. Aerobics, martial arts and artistic gymnastics (according to the structure of the group)
4. Outdoor activities - hiking and orientation
5. Basketball (practicing basic basketball elements - travelling, passing, dribbling, double
dribbling)
6. Basketball (play)
7. Table tennis and badminton
8. Table tennis and badminton
9. Volleyball (play)
10. Handball (play)
11. Aerobics, martial arts, elementary games (according to the group structure)
12. Testing motor abilities, elementary games, modern and traditional dances
12. Course methodology:method of practical exercise, method of sport training
13. Total available time 12 hours
14. Distribution of available time 0+0+2/ per week
teaching,
e-teaching
exercises,
e-exams, seminars,
team work
17. Assessment method /

17.1. Tests / oral exams 0
17.2. Seminar paper / project (presentation: written 0
and/or oral)
17.3. Attendance and participation 0
19. Signature and final exam 60% presence on the practical activities
prerequisites
21. Method of monitoring the quality of Motor tests, observation, self-evaluation
instruction
22. Literature
Required literature
1. Kukolj.M Antropomotorika Faculty of 2006
22.1. sport and
physical
education,
Belgrade
2. Wilmore, J. & Costill, Physiology of sport and Champaign: 2002
D. exercise, (Third Human Kinetic,
edition), Illinois.
3. Мalacko,J. Bases of sports training Sports 2000
(Osnove sportskog academy,
treninga) Belgrade
1. Haywood, K., & Life span motor Champaign: 2004
Getchell, N. development IL. Human
22.2.
Kinetics.
2. Magill, R. & Rouge.B Motor Learning Broun 1989
Publishers,
Louisiana
3. Malina, R., . Growth, Maturation Champaign: Malina,
Bouchard, C. & Bar – and Physical Activity IL. Human R.,
Or, O (Second Edition). Kinetics. BoucharD
1. Course title Physiology
2. Code

department)

third cycle)
6. Academic year / semester Second 7. Number of 4

semester credits
8. Lecturer/ Instructor Assistant professor Darko Bosnakovski PhD
9. Required prerequisite courses Enrolled first year of studies
10. Course objectives (competencies): Introduction to the normal functioning of the human
body and the basic mechanisms of normal functioning of individual organ systems.
During the practical training the students test their theoretical knowledge with the
performance of exercises and experiments in the laboratory and at the same time they
can see some reactions and mechanisms in vitro conditions.
11. Course content:
1. Introduction to Physiology - functional organization and general body cell

organization
2. Bodily fluids and electrolytes, blood
3. Cardiovascular system
4. Nervous system
5. Muscle system
6. Respiratory system
7. Digestive system
8. Urinary system
9. Reproductive system
10. Endocrine system
11. Thermoregulation and metabolism
12.Sensory system
1. Basic elements and function of blood and blood plasma
2. Neuro-muscular system, mionerval link
3. Endocrine glands
4. Heart and the heartbeat, factors that affect heart rate and its registration
5. Breathing system and vital capacity
6. Resorption of nutrients and giving injections
7. Saliva, gastric juice, bile
8. Urinary system
9. Reproductive system - female
10. Reproductive system - male
11. Supply of materials and energy and determination of calorific value of nutrients
12. Thermometers, thermoregulation and getting hypothermia
Interactive teaching: lectures in large groups, discussions and engaging students.
Multimedia teaching.
E-learning.
Continuous on-line contact with students.
Individual consultations with students and consultation groups.
Practical laboratory exercises in small groups.
Auditorial exercises.
Final exercise.
13. Total available time 4 ECTS х 30 hours =120 hours

teaching,
e-teaching

exercises,

work

oral)


prerequisites

instruction
22. Literature
Required literature
1. Gayton C.A.. Физиологија човјека и Медицинска 1995

механизми болести. наклада,
Загреб.
22.1. 2. Физиологија со Филозофски 2007

функционална факултет,
Трајковски В.
анатомија Институт за
дефектологи
ја, Скопје.
3. Ицко Ѓоргоски, Митко Физиолошки ПМФ-Скопје 2006

И. Младенов практикум
22.2. Supplementary literature

1. Практикум по Трајковски В, Рашиќ Филозофски 2008

физиологија со О. факултет,
функционална Институт за
анатомија дефектологи
ја, Скопје.
2. Physiology Linda Costanzo Saunders 2006
3. Human Physiology: The Arthur Vander and McGraw-Hill 2006

Mechanisms of Body James Sherman and Education
Function - 8th Edition Dorothy Luciano
1. Course title Biochemistry
2. Code

programme(unit or
institute, faculty,
department)
6. Academic year / semester Second semester 7. Number of credits 4
8. Lecturer/ Instructor Assistant Professor Tatjana Ruskovska, PhD
9. Required prerequisite
courses
Acquiring theoretical and practical knowledge about life functions through learning about the
structure, biochemical functions and metabolism of biomolecules, regulation of biosynthesis
and degradation, and integration of metabolism.
11. Course content:
- Water and electrolytes
- Proteins – classification, structure, function and metabolism
- Lipids – classification, structure, function and metabolism
- Carbohydrates – classification, structure, function and metabolism
- Enzymes and coenzymes – structure and mechanism of reactions
- Nucleic acids – structure and biosynthesis of proteins
- Conservation of energy and integration of metabolism
Teaching, laboratory experiments, work in groups and individual work.
13. Total available time 4 EKTS x 30 hours =120 hours
14. Distribution of available time 30+15+15+15+45=120
15. Forms of teaching 15.1. Lectures - theoretical teaching 30 hours
activities
15.2. Practice(laboratory, theoretical), 15 hours
seminars, teamwork
17. Assessment method:

Interactive method, group work, lectures, homework, papers, discussion, debate, cooperative
learning techniques, Individual work, simulation for extracurricular educational activities, self-
study, etc.
/grade) 51 to 60 points 6 (six) (E)
19. Signature and final exam
prerequisites
22. Literature
Required literature
1. Карлсон Биохемија и Нид 2012
патобиохемија “Микена”-
Битола
22.1.
2. Лениџер Принципи на Нид 2012
биохемија “Микена”-
Битола
3. Кетрин Декистон, Општа, органска и Табернакул 1999
Џозев Топинг, Роберт биохемија
Корект
1. Џекова С. и сор. Биохемија Нип “Форум” 2005
Скопје
2. Т. Рушковска Основи на биохемија УГД 1993
1. Course title Microbiology and Parasitology
2. Code


third cycle)
6. Academic year / semester 2013-2014 /II 7. Number of 6

credits
8. Lecturer/ Instructor Ass. prof. d-r Vaso Taleski, MD, D-r Sc.
Ass. d-r Marina Danilova
Basic aim of the course program is to introduce and enable students to acquire
theoretical, practical knowledge, skills and competences in field of microbiology
1. Introduction of history and development of microbiology science,

significance of microorganisms. Classification of bacteria, taxonomic
categories, nomenclature, size, shape and disposition of bacteria
2. Morphology and structure of bacterial cells: capsule, cell wall, cytoplasmic
membrane, cytoplasm and cytoplasmic inclusions, fimbrae and pili,
flagellum, bacterial spores, bacterial movement. Conditions for growth and
multiplication, growth phases, bacterial colonies
3. Chemical composition of bacteria, metabolism, mechanism of bacterial
feeding, metabolism of energy
4. Metabolism of nucleic acids. DNA replication. Nucleic acids decomposition
Bacterial genetics. Bacterial phenotype and genotype variations. Gene
transfer
5. Spreading of microorganisms. Associations of microorganisms.
Pathogenicity and virulence. Infections and infective diseases. Nonspecific
and specific immunity in humans. Immunotherapy and immune-prophylaxis.
6. Sterilization and disinfection. Antibiotics and chemiotherapeutics.
Microorganism’s resistance toward antibiotics. Side effects of
chemiotherapeutics.
7. Aerobic and anaerobic Gram positive and negative cocci.
8. Gram negative rods. Gram positive rods: sopreforming and non-
sporeforming
9. Spiral bacteria. Rickettsia. Mycobacteria. Actinomyces,Nocardia
10. Morphology, structure, classification and multiplication of viruses.
Importance of viral infections
11. Most important DNA and RNA viruses
12. Morphology, structure, classification and multiplication of fungi. Morphology,
structure, classification and importance of parasites
1. Principles of safety work in microbiology laboratory. Sampling, packaging and

delivering samples for microbiological testing
2. Microscope and microscopic examinations of microorganisms (light
microscope, fluorescence microscope, electron microscope). Staining of
microorganisms (Gram, Giemsa, Ziehl-Neelsen)
3. Culture media and bacterial cultivation. Identification of bacteria (classical
biochemical reactions, automatic systems for identification)
4. Antibiotic susceptibility testing of bacteria/antibiogram (classical diffusion and
dilution methods, automatic systems, E-test). Hemocultures
5. Microbiological diagnosis of wound infections and respiratory infections
6. Microbiological diagnosis of genital-urinary and sexually transmitted infections
7. Microbiological diagnosis of enteropathogens
8. Classical serologic reactions. Rapid tests
9. Immune-enzymes methods (ELISA, VIDAS)
10. Sterilization and Disinfection
11. Methods of viral diagnosis. Hepatitis markers. Diagnosis of HIV infections.
12. Diagnosis of yeasts and parasites
12. Course methodology: Methods of oral and visual learning/presentations and practical
work in the lab.
15. Forms of teaching activities 15.1. lectures / theoretical

teaching, e-teaching 30 hours

exercises,
45 hours
work

oral)
17.3. Attendance and participation during lecturing 10 points
17.4 Attendance and participation during lab practical work 10 points
17.5 Final exam 30 points

19. Signature and final exam Requirements for signature: presence at

prerequisites lectures and practical work.
Requirements for final exam: at least 42 points

from two colloquia, presence at lectures,
practical lab work and seminars (paper/project -
presentation. Colloquia are not conditionally
connected. For students with points over 37 and
less than 42, professor could organize
additional colloquium with maximum of 10
additional points
21. Method of monitoring the quality of Student evaluation

instruction
Self-evaluation
22. Literature
Required literature
1. Greenwood D. et all. Medical microbiology Project of the 17-

Government edition,
of the
22.1. 2006,
Republic of
Macedonia, Translat
for translation ed in
of vocational 2011
and scientific
books
2. Institute of
Microbiology
Panovski N. et all. Medical microbiology
and
Guest / invited author: - General part parasitology, 2011
Vaso Taleski Medical
faculty
Skopje.
3. Institute of
Microbiology
Panovski N. et all. Medical microbiology
and
Guest / invited author: - Special part parasitology, 2011
Vaso Taleski Medical
faculty
Skopje.
4. Jawetz, Melnick, & “Medical Microbiology” The McGraw- 24th ed.,

Adelberg Hill 2007
Companies
1. Milena Petrovska et all. “Handbook on medical Institute of

microbiology and Microbiology
5th ed.
parasitology” and
22.2. parasitology, 2010
Medical
faculty
Skopje,
2. Vaso Taleski “Microbiology” Authorized 2008

presentations
1. Course title Nursing care
2. Code


third cycle)
6. Academic year / semester 2012/2013 7. Number of 6

second credits
8. Lecturer/ Instructor Doc.dr.Gordana Panova
9. Required prerequisite courses Enrolled in second, third year
10. Course objectives (competencies): Teaching unit contributes primarily to the

development of the following general and specific competences: Understanding the
role of the nurse not only as the performance of duty but mandatory input of love and
compassion in working with patients on admission procedures sick, making of the
hospital bed and changing the bed cover, perform physical measurements, an
emergency procedure when applied knowledge of various types of diets with different
diseases, measuring temperature and differentiating temperature curves, measurement
of pulse and blood pressure, preparing the patient for diagnostic tests,catheterization,
giving parenteral and intravenous injection, knowledge of the sources of infection and
measures for personal protection, mode of treatment for anaphylactic shock, collapse
and coma, placement and care of the operated patients, nourishing terminally ill and
recognizing the signs of dying and determination of death.
Familiarization with the content and importance of the course Nursing care;
Organization of hospitals and hospital service;

Hospital room, hospital bed and hospital cover;
Admission of patients (new sick and emergency);
Nutrition of patients, cleanliness of the body of the patient and the patient's care for
mental mood;
Observation of the patient, vital signs, and the relationship between them;
Diagnostic testing on the patient;
Control of defecation, urination and care for vomiting;
Storage and delivery of drugs;
Entering injectable drugs in the body;
Prevention and protection against infection;
Medically - tehnical operations in which the nurse assist the physician;
Taking actions in case of anaphylactic shock, collapse, coma and acute respiratory
failure (ARI);
Care of surgical patients;
Care of the elderly, chronically ill and deathbed patients;
12. Course methodology:lecture, exercises, consultations

teaching,
e-teaching

exercises,
work

oral)
19. Signature and final exam Passed two colloquia, attendance on lectures
prerequisites and presentation of seminar paper, and scored
at least 42 points.
21. Method of monitoring the quality of Self-evaluation: Immediate lectures (face to

instruction face) with multimedia presentations, interactive
lessons, conducting practical classes equipped
with cabinets, work phantoms, divide students
into pairs called (role playing) and use of other
educational aids and teaching aids
Written and oral presentation of the learning

content,practical examples from hospitals
22. Literature
Required literature
1. Doc.dr.G.Panova Helth Care painful UGD-Stip 2010
22.1. 2. Dr. Likar Dusan General and special Prosvetno 2010

care of the sick; delo-Skopje
3. Barham P.. A. Care of the ill and Tabernakul- 2011

medical equipment; Skopje
1. Fuchkar G. Process of health MedicalSchool 2007

care; - Zagreb
22.2.
2. Krstic A. New content sister Faculty of 2005
work; Medicine,
Belgrade,
3. Rozen, Berkin Preventive Health Tabernakul 2011

Care Skopje
1. Course title Ecology and hygiene
2. Code


third cycle)
6. Academic year / semester 7. Number of 2

credits
Second
semester
9. Required prerequisite courses Enrolled second year of studies
10. Course objectives (competencies): The purpose of this subject is for

the students to gain basic knowledge from the area of medical ecology, the protection
of the environment and hygiene.
11. Course content:
 Introduction to ecology
 Air pollution
 Water pollution
 Waste materials
 Chemical components in the environment
 Climate and Microclimate
 Radiation, Noise
 Introduction to hygiene
 Hygiene in public and communal facilities
 Education facilities hygiene
 Health facilities hygiene
 Personal hygiene
Lectures,exercises,seminars and practical activities

teaching,
e-teaching

exercises,

work

oral)


prerequisites

instruction
22. Literature
Required literature
1. Michail Kocubovski Hygiene whit medical University of 2011

ecology Goce Delcev
22.1.
- Stip
2. R. Čosic Udzbenik Higiene 1983
3. Milto Mulev Protection of the 1997

environment
1. Kocijancic Radojka Higiena Zavod za 2002

22.2.
udzbenike I
nastavna
sredstva,
Beograd
Annex No.3
1. Course title Epidemiology

2. Code

program(unit or institute,
Faculty, department)
8. Lecturer/ Instructor Prof. Dr. Gorgi Shumanov, PhD
9. Required prerequisite Verified first semester
courses
Acquiring a basic knowledge of epidemiology and public health. Introduction to measures for
prevention and combat diseases and health deterioration. The student will gain knowledge of
the epidemiological characteristics of infectious (intestinal, respiratory, transmissible
infectious diseases, zoonoses and other diseases) and non-infectuous (cardiovascular
disease, cancer, diabetes, traumatism) diseases.
11. Course content:
1. Epidemic process
2. Epidemiological methods
3. Types of outbreaks.
4. Forms of epidemic process
5. The occurrence of infection and communicable diseases and ways of transmitting
infectious diseases.
6. Prevention of disease and ill-health.
7. Preventive medical care in military and emergency conditions.
8. Epidemiological features of intestinal infectious diseases.
9. Epidemiological characteristics of infectious respiratory diseases.
10. Epidemiological characteristics of infectious disease transmission.
11. Epidemiological features of zoonoses.
12. Epidemiological characteristics of non-communicable diseases and health damage.
Practical instruction:
1. Epidemiological methods and design studies
2. Methods of collecting information, epidemiological survey, sample
3. Epidemic process, forms the epidemic process, epidemiological models of disease
occurrence
4. Epidemiological characteristics and examples of alimentary, drip-aerogeni, contact and
transmissible epidemic
5. Immunization: compulsory vaccination and vaccination on epidemiological indications
6. Prevention of occupational exposure
7. Epidemiological features of intestinal infectious diseases
8. Epidemiological characteristics of infectious respiratory diseases
9. Epidemiological features of contact diseases
10. Epidemiological features of transmissible infectious diseases
11. Epidemiological features of chronic non-communicable diseases
12. Epidemiological features of malignant neoplasm, diabetes, addictions.
12. Course methodology:Lectures, exercises, methods of group discussions, individual
assignments, seminar papers, presentation of a scientific work
14. Distribution of available time 30+15+15
15. Forms of teaching 15.1. lectures - theoretical teaching 30 hours
activities
15.2. Practice(laboratory,theoretical), 15 hours
seminars, teamwork

18. Grading system (points /grade) up 50 points 5 (five) (F)
19. Signature and final exam Attendance and scored at least 42 points from all pre-
prerequisites exam activities.
21. Method of monitoring the quality Self evaluation
of instruction
22. Literature
Required literature
1. Gorgi Shumanov, Epidemiology and "Progress", 2009
Blaze Nikolovski Public Health Tetovo
22.1.
2. Theodor H.Tulchinski New Public Health Student word 2003

Elena A.Varavikova "Skopje
3. Lence Mircevska, Health education Bitola 2006

Doncho Donev, Ilija
Gligorov
22.2.
1. Blaze Nikolovski Epidemiology "Progress", 2003
Tetovo
Annex No. 3 Course Programme - first cycle studies
1. Course title Computer science
2. Code

programme(unit orinstitute, faculty,
department)
5. Level of studies (first, second, or third First cycle
study cycle)
8. Lecturer/ Instructor Ass. Professor Zoran Zdravev, PhD
10 Course objectives(competencies):
. Adopting the basic concepts of computer science and concepts for using computers for
communication, research and office work
11 Course content:
. Introduction to computer science: algorithms, abstraction, history,
Computer hardware: introduction, types, architecture of computer systems, Murau law
Computer hardware: Peripherals, Computer Memory, digital identification;
Computer software: applicative software, open source software licenses;
Computer software: system software, programming languages;
Computer software: web services, online document storage and editing systems,
Computer networks: LAN, MAN, WAN, topologies, applications that run on network
components, connectivity;
Computer networks: Internet, intranet, extranet, Internet services;
Computer security: a concept, a security risk, malicious software, unauthorized access,
cryptography;
Information systems: introduction, types, ERP, CRM, HR, SCM;
Content Management Systems CMS: DMS, DAMS, WCM, ECP, ERS;
Databases: fundamentals, types, use
12 Course methodology: lectures, laboratory exercises, e-learning, individual and team projects,
. consultations.
13 Total available time 4 ECTS х 30 h = 120 hours
.
14 Distribution of available time 30+15+15+10 +50 = 120 hours
.
15 Forms of teaching activities 15.1 lectures / theoretical 30 hours
. teaching, e-teaching
15.2 theoretical and practical 15 hours
exercises,
work
16 Other forms of activities 16.1 Project work 15 hours
. 16.2 Individual work 10 hours
16.3 Homework 50 hours
17 Assessment method
17.1 Tests / oral exams 70 points
17.2 Seminar paper/project (presentation: written and/or oral) 10 points
17.3 Attendance and participation 20 points
18 Grading system (points /grade) Up 50 points 5 (five) (F)
19 Signature and final exam prerequisites 60% of term activities or minimum 42 points from 2
midterm exams, project activities and attendance
on lectures and discussions
20 Language of instruction Macedonian
21 Method of monitoring the quality of Self-evaluation
instruction
22. Literature
Required literature

1. Zoran Zdravev etc.. Informatics - script UGD 2012
22.1.
2. Zoran Zdravev etc.. Practicum in UGD 2012
Practicum in Informatics Informatics
UGD 2012
3.

1. Glenn Brookshear „Computer Science – Pearson 2009
an overview“ International
22.2.
edition
2. Carl Reynolds and Paul „Principles of Computer McGraw Hill 2008
Tymann Science“
3. James O’Brien „Introduction to McGraw Hill 2008
Information Systems “
Annex No.3
1. Course title Pathophysiology
2. Code
4. Organizer of the study University Goce Delcev

Faculty of Medical science

and third cycle)
6. Academic year / semester Second year / third 7. Number of 6

semester credits
8. Lecturer/ Instructor Prof. dr. Zoran Handziski
9. Required prerequisite courses /
10. Course objectives (competencies): Introducing the students with the general
malfunctions and pathophysiological processes of the organism.
11. Course content:
1. Disorders of the structure and function of macromolecules
2. Disorders of subcelular structures
3. Disorders of energy metabolism and the metabolism of essential nutrients
4. Disorders of the turnover ofspecific metabolic compounds
5. Disorders of the turnover of water and electrolytes.
6. Disorders of the acid-base balance
7. Biologically active endogenous compounds in the pathophysiological processes
8. Disorders of neuro-vegetative regulation. Pathophysiological basis of pain.
9. Disorders of thermoregulation. Imunopathophysiology
10. Inflammation. Overall response of the organism to the harmful effects.
11. Circulatory shock. Disturbance of consciousness.
12. Disorders of development and growth. Malignant transformation and growth.
1. Pathophysiological basis of inheritance of diseases and syndromes
2. Cell death
3. Substrate hipoenergosis-starvation
4. Disorders of protein metabolism
5. Disorders of purine metabolism-Gout
6. Disorders of calcium, phosphate and magnesium turnover
7. Gastrointestinal hormones and neuropeptides
8. Reactions of tissue transplantation
9. Pathophysiology of aging
12. Course methodology: interactive teaching of lectures and tutorials, practical exercises.
15. Forms of teaching activities 15.1. lectures / theoretical teaching, 30 hours
e-teaching

exercises,

19. Signature and final exam  The Assessment method is based on the
prerequisites accumulation of points scored: lectures,
tutorials, colloquia and seminar paper;
• colloquia are independent of each other,
i.e. passing one is not a prerequisite for
taking other colloquium;
• The final exam also does not depend on
colloquiums, they are not a requirement for
passing the final exam, but the total
number of points scored, which should not
be less than 42 points;
• In case of insufficient number of points for
passing the final exam, the professor can
arrange additional colloquium or additional
activity when it has a sufficient number of
candidates.

of instruction
22. Literature
Required literature

22.1.
1. Gamulin S et al. Pathophysiology 6th edition , 2005
Zagreb
2. Vaskova O et al. Practicum in general Skopje
and special
pathological physiology
3. Tadzer I et all. General pathological Belgrade

physiology
22.2.
Annex No.3
1. Course title Pathology
2. Code

Faculty of Medical Sciences
department)
Department of Pathology

third cycle)
6. Academic year / semester second year / 7. Number of 6

third semester credits
8. Lecturer/ Instructor Prof. Gordana Petrushevska, MD, PhD
10. Course objectives (competencies): Acquiring knowledge about etiology, mechanisms

and morphological changes in cells and tissues of the human organism under the
influence of pathological agents and diagnosis of those changes.
11. Course content:
1. Cell injuries, Cell Death, and Adaptations;
2. Acute and Chronic Inflammation;
3. Tissue Repair: Regeneration, Healing, and Fibrosis;
4. Hemodynamic Disorders, Thrombosis, and Shock;
5. Diseases of the Immune System;
6. Neoplasia;
7. Genetic and Pediatric Diseases;
8. Environmental and Nutritional Diseases;
9. General Pathology of Infectious Diseases;
10. Pathology of the Blood Vessels;
theoretical lectures, practical exercises, term papers, individual presentation
15. Forms of teaching activities 15.1. lectures / theoretical 30 h

teaching,
e-teaching
15.2. theoretical and practical 45 h

exercises,

work
17.2. Seminar paper/project (presentation: written and/or 10 points

oral)
18. Grading system (points /grade) up 50 points 5 (five) (F)

19. Signature and final exam The total number of pre-exam points scored
prerequisites should not be less than 42 points.

instruction
22. Literature
Required literature
1. Kumar, Abbas, Robbins Basis of Saunders, 2010

Fausto, Mitchell Pathology, 8th Elsevier
22.1.
2. Eduard K. Klatt Robbins and Saunders, 2009
Cotran Atlas of Elsevier
Pathology
3. Authorized
Lectures
22.2.
Annex No.3
Course Programme- First cycle studies
1. Course title Pharmacology
2. Code

Faculty of Medical science

third cycle)
6. Academic year / semester Second/ Third 7. Number of 4

credits
8. Lecturer/ Instructor Ass. Professor dr. Trajan Balkanov
To introduce students with basic pharmacokinetic (absorption, distribution, metabolism

and elimination of drugs) and pharmacodinamic processes in the human organism, the
mechanism of action of drugs, factors that determine safety and efficacy, dosing and
factors affecting dosing of drugs , interactions and side effects of medications, and to
provide a review of the most basic characteristics of most drugs that are now used in
everyday practice
11. Course content:
1. Basic pharmacology, Pharmacodinamic (the effect of the drugs on the human

organism)
2. The mechanism of action of the drugs; Character of action, specificity and selectivity
3. Types of therapy, etiology, symptomatic; Quantitative aspects of the effects of drugs
4. Correlation among structure of the drug and pharmacological response; strength and
effectiveness of the drugs
5. The notion of accumulation and tolerance; mutual effect between the drugs; Side
effects on drugs (toxicity, allergic, genetically determined). Drug addiction
6. Drugs that act through the peripheral nervous system,

7. Pharmacology of the drugs that act through the central nervous system,
8. Treatment of cardiovascular disease, Haemostasis and Thrombosis, drugs that are

used in the treatment of anemia,
9. Treatment of respiratory diseases,

10. Treatment of diseases of the digestive tract,
11. The use of vitamins and hormones in daily therapy practice
12. Anti-infective drugs
12. Course methodology:Research, working in small groups, homework, practical work,

independent seminar paper, discussion, debate, individual work

teaching,
e-teaching

exercises,

work
16.2. Individual work 10 hour


oral)
19. Signature and final exam Total number of pre-exam points scored should
prerequisites not be less than 42 points.

instruction
22. Literature
Required literature
1. Ass.prof.dr. Trajan Pharmacology of authorized 2013

22.1. Balkanov dentists – general part lectures,
script
Prof.dr. Srdjan Pesic
2. Ass.prof.dr. Trajan Pharmacology of authorized 2013

Balkanov dentists – special part lectures,
Prof.dr. Srdjan Pesic script
3.
22.2.
1. Course title Introduction to internal medicine
2. Code
4. Organizer of the study University Goce Delcev, Stip


and third cycle)

semester credits
8. Lecturer/ Instructor Prof. d-r Nikola Kamcev
9. Required prerequisite courses none
- to achieve basic knowledge in the basic internal diseases in order to learn the main
principles of health care of these patients
-to be able to practically implement the theoretical knowledge of internal diseases
11. Course content:
 Diseases and conditions of the cardiovascular system

 Respiratory diseases
 Nephrology diseases
 Rheumatology diseases and conditions
12. Course methodology:interactive lectures, practical classes, project work

15. Forms of teaching activities / 15.1. Lectures / theoretical -
per week interactive teaching
45 hours
15.2. Practical exercises,
e-learning, seminar paper 30 hours
17.1. Attendance to the lectures and active participation maximum 10 points
17.2. Attendance to the practical lessons and active maximum 10 points

participation
17.3 Continuous knowledge checking through exams maximum 2x20

points
17.4. Seminar paper/project (presentation: written and/or oral) maximum 10 points

optional
17.5. Practical exam maximum 10 points
17.6 Final exam maximum 30 points
19. Signature and final exam Cumulative score of 60% of all required activities
prerequisites (midterm tests, attendance and seminar papers)

of instruction
22. Literature
Required literature
1. Vladimir Serafimovski Internal medicine Makedonska 2003

and colleagues riznica,
22.1. Kumanovo
2. Faucu D.L, Kasper D.L. Harrison’s principles of “Tabenakul”

LondoD.L. Braunwald E, internal Medicine
Skopje 2013
HauserS.L. JamesonJ.L. (Atlas), 17 -th edition
LascalroJ.
1. Charles D, Forbs, Clinical Medicine “Magor” 2010

William F, Jackson.
Skopje
22.2.
2. Ljubica Georgievska Electrocardiography Skopje: 2008
Ismail, Lidija Poposka, (COBISS.
Ivan Trajkov, Nikola MK-ID
Gjorgov 71834122)
Annex No.3
1. Course title Immunology
2. Code


and third cycle)

semester credits
8. Lecturer/ Instructor Prof. d-r Darko Bosnjakovski
10. Course objectives (competencies): Through theoretical instruction students will learn
basic concepts and components of the immune system and how they function.
Through practical instruction students will be introduced to the basic methods of
examination which immunology uses.
11. Course content:
Theoretical instruction:
1.Introduction in Immunology
2. Immune system cells and organs
3. Innate immune responses
4. Complement
5. Acquired immune responses
6. B cells
7. Antibodies
8 T cell
9. Immunological mediators
10. Tolerance
11. Autoimmunity
12. Basic concepts in clinical immunology
Practical instruction:
1. Introduction to immunology and the general of the immune system.
2. Cells of the immune system and isolation
3.Recognition molecules for the cells of the immune system
4. Lymphoid organs and tissues, recognizing of their structural components
5. Enzyme immunoassay (ELISA), Enzyme-immunological test to detect HIV
6. Immunoelectrophoresis, Zone immunoelectrophoresis, Immunofixation

electrophoresis. Applying immunoelectrophoresis.
7. Immunochemical and immuno-physical-chemical methods.Chromatography

column.Ion exchange chromatography.Gelfiltration.Affinity chromatography.
8. Methods for obtaining monoclonal antibodies.
9. Northern and Western blot.
10. Immunocytochemistry and immunofluorescent staining, Principles of

flowcytometry.
11. Intracellular cytokine staining, ELISPOT
12. PCR - polymerase chain reaction, in situ hybridization.

Lectures, group discussions methods, theoretival and laboratory exercises, individual

assignments, seminar paper, presentation of paper.
15. Forms of teaching activities 15.1. lectures / theoretical teaching, 15 h
e-teaching
15.2. theoretical and practical 15 h

exercises,
19. Signature and final exam At least 42 points acquired.

prerequisites

of instruction
22. Literature
Required literature
no. Author Name Publisher Year
1. Kubi Imunology, 6th edition Tabernakul 2011
2. Darko Bosnjakovski Basics in immunology

22.1.
authorozed lectures
3. Spiroski M, Trajkov D, et Imunoloski praktikum IIBHG< 2006
al Medical
faculty,
Skopje
no Author Name Publisher Year
1. Ivan Roitt et al. Immunology, 4th Mosby 1996
22.2.
edition
2. Helen Chapel et al Basics in clinical Tabernakul 2010
immunology
Annex No.3
1. Course title Cell biochemistry
2. Code
4. Organizer of the study Goce Delcev University


third cycle)
6. Academic year / semester Second year / 7. Number of 5

Third semester credits
8. Lecturer/ Instructor Prof. Tatjana Ruskovska
Learning about metabolic processes in the cell and in the whole organism, and their
regulation. Getting a basic knowledge about the research in cell biochemistry.
Course content:
1. Definition of the metabolism. Anabolic and catabolic processes in the organism
of the healthy people.
2. Cofactors and high-energy compounds.
3. Metabolism of carbohydrates, first part. Glycolysis.
4. Metabolic transformation of the pyruvate. The cycle of three carboxylic acids.
5. Respiratory chain and oxidative phosphorylation. Energetic contribution of the
metabolism of carbohydrates,
6. Metabolism of carbohydrates, second part. Glycogenolysis, glycogenesis,
pentose-phosphate cycle, gluconeogenesis.
7. Metabolism of the lipids. Catabolism of the 3-acylglycerols. Β-oxidation of fatty
acids and energetic contribution. Ketogenesis. Biosynthesis of fatty acids,
phospholipids and sterols. Prostaglandins.
8. Metabolism of the lipoproteins in the blood plasma.
9. Metabolism of the proteins.
10. Metabolism of the amino acids.
11. Metabolism of the porphyrins. Metabolism of the nucleotides.
12. Photosynthesis.
1. Biochemical research and its specificity.
2. Basic procedures and techniques in biochemical research.
3. Hydrodynamic methods in cellular biochemistry.
4. Application of the techniques of electrophoresis in the biochemical researches,
first part.
5. Application of the techniques of electrophoresis in the biochemical researches,
second part.
6. Application of the chromatography in analysis of the cell material.
7. Laboratory methods for investigation of mitochondrial respiration.
8. Glycolysis.
9. Pentose-phosphate cycle.
10. Metabolism of the lipids.
11. Photosynthesis.
12. Final experiment.
Interactive teaching: Lectures in large group, discussion and involvement of the

students.
Multimedia teaching.
E-teaching.
Consultation in groups and individually.
Laboratory experiments in small groups.
Theoretical discussion about some experiments.
Final experiment.
15. Forms of teaching activities 15.1. lectures / theoretical 30

teaching,
e-teaching
15.2. theoretical and practical 30

exercises,

work
16. Other forms of activities 16.1. Project work 15 Hours
16.2. Individual work 15 Hours
16.3. Homework 60 Hours

oral)

19. Signature and final exam Acquired at least 42 points

prerequisites

instruction
22. Literature
Required literature
No. Аuthor Name Publisher Year
1. S. Dzekova et al BIOHEMIJA Skopje 2006
22.1. 2. B. Gorgeska Presentations from the www.ugd.edu 2010

cell biochemistry .mk
lectures
e-learning
3. B. Gorgeska, D Internal script www.ugd.edu 2010

Gogieva, K Smilkov .mk
e-learning
22.2.
No. Author Name Publisher Year
1. Karlson Peter BIOKEMIJA udžbenik Školska 1993
za studente knjiga–
tehnološkog, Zagreb,
prehrambeno-tehnol., Превод:
biotehnol., prirodosl.- Kurzes
mat., medicinskog i Lehrbuch der
farmaceutsko-biokem. Biochemi
fak. - 8.izd. prema
12.nj.
2. Stryer, Lubert BIOKEMIJA Školska 1991

knjiga–
Zagreb,876
str. Превод:
Biochemistry,
2nd ed. или
L. Stryer:
BIOCHEMIS
TRY, W. H.
Freeman,
New York,
2006
Annex No.3
Course Programme- first/second/third cycle studies
1. Course title Good Laboratory Practice
2. Code


third cycle)

third semester credits
8. Lecturer/ Instructor PhD. Prof. Biljana Gjorgjeska
The aim is to introduce the regulations, development, meaning and content of quality
systems and good laboratory practice (GLP) with separate processing elements of the
quality assurance system and its importance to the pharmaceutical industry.
11. Course content:
Theoretical instrunction
Introduction (Introduction to course content)

International regulations:
1. WHO recommendations
2. EU - Directives
3. USA - legislation (FDA) - differences in relation to the EU;
4. ISO / IEC 17025
5. Accreditation
Regulation in Republic of Macedonia-compared with international regulations:
1. Drug Law, 2. Regulations; 3.Farmacopea.
Good laboratory practice in pharmacy: in the world (EU, USA) and the requirements
today. Documentation system for quality assurance.
Examples of questions and tasks
Development of practical examples and problems in the implementation of standards of

good laboratory practice. Reviewing the process of introducing, implementation and
accreditation.
Final exercise
Lectures, practical laboratory work, individual assignments, group discussion methods.
13. Total available time 150

teaching,
e-teaching

exercises,

work
16. Other forms of activities 16.1. Project work 15hours


oral)
19. Signature and final exam The student is responsible to actively monitor all
prerequisites the activities for which it wins points which
include participation in the ongoing review of
knowledge, to get a signature and to obtain
necessary number of points to be able to take
the final exam.
Criteria for passing:
• The Assessment method is based on the

cumulation of points won from : lectures,
exercises, colloquiums and seminar paper;
• colloquia are independent of each other, i.e.

taking one is not a prerequisite for taking the
other colloquium;
• The final exam is also not dependent on the

midterm, they are not a requirement for passing
the final exam, but the total number of points
scored, which should not be less than 42 points;
arrange additional colloquium, when there is
sufficient number of candidates
21. Method of monitoring the quality of Continuous checking of knowledge:

instruction
two written tests (colloquia)
Final exam: written and oral
Self evaluation
22. Literature
Required literature
1. B. Gorgeska Lecture presentations www.ugd.edu

.mk
е-learning
2. Handbook: good World Health 2009

22.1.
laboratory practice (GLP): Organization
quality practices for
regulated non-clinical
research and
development -2nd ed
3. ЗАКОН ЗА ЛЕКОВИТЕ И Сл. весник

МЕДИЦИНСКИТЕ на РМ
ПОМАГАЛА
4. Quality assurance of World Health 2007

Organization
Pharmaceuticals, Volume
2, 2nd updated edition,
Good manufacturing
practices
and inspection
5.
1. Б. Ѓорѓеска ˝Документациона основа www.ugd.edu 2013

за безбедно управување .mk
со квалитетот во
Национална
лабораторија за лекови˝
2. Leonard Steinborn GMP/ISO CRC Press 2003

LLC
Quality Audit Manual for
Healthcare Manufacturers
and Their Suppliers

22.2.
3. Comparison Chart of FDA U.S. 2004
and EPA
Department
Good Laboratory Practice of Health and
(GLP) Regulations Human
Services
and the OECD Principles
of GLP Food and
Drug
Administratio
n
Office of
Regulatory
Affairs (ORA)
Annex No.3
1. Course title Analytical chemistry
2. Code

department)

third cycle)

forth semester credits
The aim is to introduce the fundamentals of analytical chemistry, including chemical

analysis, chemical equilibrium, settling reactions, qualitative and quantitative chemical
analysis and titrimetric analyses.
The purpose of practical work (exercise) is for students to gain knowledge in the field of
chemical analysis. During the laboratory work the students produce chemical analysis,
calculate results and resolve chemical problems.
11. Course content:
1. An introduction to teaching course content. Subject and tasks of analytical chemistry
2. Theory of electrolyte dissociation, degree of el. dissociation, activity in the ions.
Brenshted-Lori, Arenious and Louis theories
3. Water ionization and hydrogen indicator, salt hydrolysis, pH measurement
4. Bufferes, pH of solutions (weak, strong electrolytes and amfolites)
5. Equilibrium in heterogeneous systems, precipitation, dissolution of sediments,
6. Complex compounds balance.
Classical analytical methods

1. Quantitative analysis. Volumetry and titrimetric analyses: definitions, principles and
classification
2. Gravimetry: Principle of operation, types of sediments and measuring mass
Modern analytical methods

1. Separating techniques and fundamentals of chromatography , liquid –liquid
extraction, gas chromatography , HPLC, electrophoresis and electrochromatography .
2. Spectrometric techniques: introduction, radiation and electromagnetic energy level
atomic and molecular spectroscopy, emission spectrometry : flame atomic emission
spectrometry ; spectrometry with inductively coupled plasma .
3. Absorption spectrometry: atomic absorption and atomic fluorescence spectrometry,
ultraviolet and visible spectroscopy, mass spectrometry: basic principles and
application of the technique.
4. Fundamentals of electrochemical methods : potenciometry and pH-metry
1. Solutions, quantitative expression of the composition of the solutions, chemical

equilibrium in homogeneous systems
2. pH , ionic product of water
3. Buffers
4. Product solubility
5. Equilibrium in solutions of weak acids and weak bases
6. Qualitative analysis of cations
7. Qualitative analysis of anions
8. Quantitative analysis ( volumetric methods) – alcalimetry and argentometry
9. Quantitative analysis ( volumetric methods) – complexometry and permanganometry
10. Planar chromatographic methods
11. Spectrophotometric methods : Beer - Lambert law
12. Electrochemical methods : potenciometry and amperometry

teaching,
e-teaching

exercises,

work


oral)
19. Signature and final exam Two partial exams (colloquia) on theoretical
prerequisites lectures and laboratory exercises. The final
assessment is defined by student’s activity and
the knowledge of theoretical lectures, laboratory
exercises and quality of seminar paper.

instruction
Self evaluation
22. Literature
Required literature
22.1. No. Author Title Publisher Year
1. D. Kelly, P.J, Hains, Analytical chemistry Publishers 2002

Limited,
BIOS Scientific. Oxford, UK
2. B. Daglas, A. Scug, Introduction to Просветно 2009

Donald M West F. analytical chemistry дело Скопје
James Holer Stanley R.
(translated to
Crouch.
Macedonian)
1. Valentin Mirceski Analiticka hemija za

22.2. farmacevti
2.
3.
Annex No.3
1. Course title Introduction to transfusiology
2. Code


third cycle)

8. Lecturer/ Instructor Prof. Dr. Nikola Kamcev
The aim is to introduce student to the fundamentals of transfusiology.
11. Course content:
• Transfusiology as a science
• Blood donation process
• Special types of blood donation
• ABO groups - blood system

• Rh system and other blood group systems
• Transmission of infectious agents by transfusion
• Ethical aspects related to blood transfusion
• Pre-transfusion testing
• Blood components
• Adverse effects of transfusion
• Diagnosis and treatment of clinical conditions with defects of coagulation factors
• Acceptance and testing of blood donor
• Venepuncture
• Treatment of donated blood
• Determination of blood group
• Determination of the Rh system
• Cross-testing between the blood samples of the patient and donor
• Blood plasma components
• Basic tests of hemostasis
• Control of oral anticoagulant therapy
• Transfusion-transmissible infections (tests)
• Imunohematological analysis
• Promotion of blood donation


teaching,
e-teaching

exercises,

work

oral)
19. Signature and final exam At least 42 points acquired.

prerequisites

instruction
Annex No.3
1. Course title Medical cytology
2. Code

Faculty of medical science

third cycle)

The purpose of this subject is for the students to get familiar whit the routines,
techniques and methods that are related whit microscopy as well to get basic
knowledge from the area of cell biology. They study the cell chemical methods used in
medicine and are especially important during diagnosing certain diseases. With this the
students develop specific competences in development of scientific research
procedures that are used with microscopy, building an analytical approach that will be
used during the diagnostic of certain hereditary and nonhereditary diseases. In the
Cytology part the students develop basic theoretical foreknowledge for the cell and for
the cell organelles, especially the nucleus structure and constitution of the whole
genetic material. All membrane and nonmembrane organelles are included with special
emphasis on their functions and associated pathologies. In this way the students will be
able to identify a normal cell from physiologically amended cell. Also the students have
a goal to get familiar whit the structure and function of macromolecules in the living cell
and the clinical-biochemical correlations in it. All the theoretical knowledge that the
students gather in this subject is controlled and determined with practical laboratory
work and practice.
11. Course content:
 Review the cell and cytoplasm

 Chemical composition of the cell;
 Cell membrane structure;
 Transport through the cell membrane;
 Endoplasmic reticulum structure;
 Golgi apparatus structure;
 Mitochondrial structure;
 Structure of lysosomes and peroxisomes;
 Nucleus structure
 Cell division;
 Cell differentiation.
 Apoptosis;
Lectures,exercises,research and practical activities

teaching,
e-teaching

exercises,

work


oral)

prerequisites
21. Method of monitoring the quality of Evaluation of the knowledge is continuous and it
instruction is accomplished by evaluating seminar papers,
essays, oral presentations, participation in
discussions, tests and other ways of testing the
knowledge. On the basis of all actions applied
and evaluated, including the final exam, it
evaluates the quality of instruction.
22. Literature
Required literature
22.1.
1. Michael H..Ross; Cell and molecular Табернакул 2010
biology
Pavlina Vojnic
2. Tomas Pollard; William Cell Biology Elsevier 2008

Earnshaw
3. Liljana Bozinovska Physiology of the

eukaryotic cell

22.2.
1. Danica Roganivik - Cytology
Zafirova
Annex No.3
1. Course title Biostatistics
2. Code


and third cycle)
6. Academic year / semester Second year / forth 7. Number of 4

semester credits
8. Lecturer/ Instructor Prof.Milka Zdravkovska, MD, PhD
10. Course objectives (competencies): Acquiring knowledge about the basics of medical
biostatistics - ways of collecting data, grouping the data series and their statistical table
and graph.
11. Course content:
1. Concept and development of bistatistics ; statistical table , sample units, types and
properties of statistics , statistical series (atributiv, numerical, spatial, temporal)
2. Methods of data collection: census, registration and preparation of reports, method

of questionnaire - a survey.
3. Tabular and graphical presentation of statistical series. Analysis of the structure of

the series atributive tokens (ie, proportions, rates and indices) .
4. Analysis of the structure of the series with numerical characteristics (mean, median,
mode).
5. Measures of variability: mean deviation, variance and standard deviation , coefficient

of variation .
6. Hypotheses / testing of hypotheses, analysis of statistical relationships in series with

atributive marks (x 2 test and contingency coefficient) .
7. Analysis of relationships in series with numerical characters (Pearson- correlation

coefficient, Spearman- rank correlation coefficient and multiple correlation ) .
8. Method of sampling , estimation of parameters of the sample ( parameter π and the

parameter μ)
9. Testing the significance of differences between the two environments and arithmetic
between two proportions (Student- t t- test for independent and dependent samples ) .
10. Examination of the dynamics of phenomena ( trend , seasonal index)
11. Vital statistics, concepts and sources in demographic statistics.
12. Application of computer science technology in medicine.
1. Plan for stastistic research.
2. Indices of dynamics with constant and variable basis.
3 Calculating the arithmetic mean in nongroup data, grouped in the interval group and
the group without grouped interval.
4. Calculating the median and the mode for nongrouped and grouped data.
5. Standard deviation in nongrouped and grouped data; Coefficient of variation.
6. Calculating the expected frequencies and x2 test.
7. Pearson-correlation coefficient of correlation in nongroup data.
8. Estimation of parameters of the sample (π parameter and the parameter μ)

9. Student-test for two independent large samples and in two proportions.
10. Linear trend of time series (for odd and even number of years) Seasonal index.
11. Calculating birth rates, fertility, mortality, morbidity, natural population growth.
12. Presentation of the statistical program.
Small group work, homework, practical work, project assignments, discussion.
e-teaching
15.2. theoretical and practical exercises, 15 h
16. Other forms of activities 16.1. Project work 15 h
16.3. Homework 60 h

19. Signature and final exam Scored at least 42 points on all grounds (lectures,
prerequisites tutorials, colloquia, seminar paper)
21. Method ofmonitoringthe quality of Self evaluation

teaching
22. Literature
Required literature
1.
22.1. 2. Jamie F.. Dzhekel, Epidemiology, Springer 2010

David L.. Katz, Joan J.. Biostatistics and
Elmore, Dorothea MJ Preventive Medicine
Wilde
3.
22.2.
Annex No.3
1. Course title Instrumental analysis
2. Code


and third cycle)

semester credits
8. Lecturer/ Instructor Prof.Dr. Rubin Gulaboski
10. Course objectives (competencies): Acquiring knowledge about the basics of

instrumental analysis.
11. Course content:
UV-VIS spectrophotometry, Atomic absorption and Emission spectrometry,

Luminiscent methods, Infrared spectrometry, and Turbidimetrics and Nefelometrics,
Refractometrics and Polarimetrics, Mass spectrometry, Centrifugal methods,
Chromatographic methods, General part, Liquid and Gas chromatography.
Electrophoretic techniques, Potentiometric Electrochemical Techniques
e-teaching
15.2. theoretical and practical exercises, 30 h
16.3. Homework 70 h

21. Method ofmonitoring the quality of Self evaluation

instruction
22. Literature
Required literature
no Author Name Издавач Година
1. David Harvey Modern analytical Prosvetno 2009

chemistry delo
22.1.
2. А.Veljanovski Instrumentalni metodi Studentski 1995
vo farmacevtskite zbor
analizi
3.
22.2.
no Author Name Publisher Year
Annex No.3
1. Course title Nutritionism - modeling and optimisation
2. Code


and third cycle)

semester credits
8. Lecturer/ Instructor Prof.Dr. Nako Taskov
10. Course objectives (competencies): Through lectures, exercises-workshops,

consultations and prepared seminar paper students shall meet and engage in different
forms, methods, learning strategies and academic research to acquire the theoretical
and practical knowledge related to nutrition.
11. Course content :
1. Basic ingredients
2. Factors that determine nutrition
3. Making the daily meal
4. Energetic metabolism
5. Digestibility of the food

6. Quality of nutrition
7. Quality of food products
8. Losses of the food that can not be reused
9. Losses in thermal processing of foods
10. Nutrition according to age and physical activity
11. Nutrition as prevention of illness
12. Prepared food, organoleptic characteristics
e-teaching
15.2. theoretical and practical exercises,
16.2. Individual work
16.3. Homework 20 h

21. Method ofmonitoringthe quality of Self-evaluation

instruction
22. Literature
Required literature
22.1.
1. Taskov N. “Ishrana i dietetika”
Internal script
1. Garrow S. J., „Human Nutrition and Elsevier 2000
Ralph A., William Diet“
Philip Trehearne
22.2.
James,
2. Rosic M., Rosic Principi ishrane i University 2009
G., Angelkovic I., rekreacije Singidunum,
Belgrade
3.
Annex No.3 Course Programme - first cycle of studies
1. Course title Public Health
2. Code
4. Organiser of the study Faculty of Medical Sciences

programme(unit i.e. institute,
department)

cycle)
6. Academic year / Semester Second year / 7. Credits 2

fourth semester
8. Lecturer/ Instructor Professor D-r Gorgi Sumanov
10. Course objectives (competencies): Acquisition of basic knowledge of the role, need
and content of public health; certain infectious and chronic non infectious diseases as a
public health problem.
11. Course content:
1. Introduction to public health; Organizational setup and goals;

2. Intestinal infectious diseases – public health aspects
3. Respiratory infectious diseases - public health aspects
4. Transmissive infectious diseases - public health aspects
5. Blood and sexually transmited infectious diseases - public health aspects
6. Intrahospital infections; antibiotics resistance as a public health problem
7. Periods of occurrence of chronic degenerative diseases and level of prevention
8. Cardiovascular and cerebrovascular diseases - public health aspects
9. Diabetes and its chronic complications as a public health problem
10. Neoplasms - public health aspects
11. Chronic obstructive pulmonary disease and ulcer disease
12. Addiction diseases as a public health problem
12. Course methodology: Lectures, group discussion methods, individual assignments,
seminar papers;
13. Total time available 60 hours
14. Distribution of the available time 2+0+1

education
15.2. Practice(laboratory
theoretical), seminar
papers, teamwork
16. Other forms of activities 16.1. Project work 0
17.1. Tests and a final oral exam 70 points
17.2. Seminar paper/project ( presentation: written and oral ) 10 points
18. Grading system (points / grade) tо 50 points 5 (five) (F)
from 51 tо 60 points 6 (six) (E)
from 61 tо 70 points 7 (seven) (D)
from 71 tо 80 points 8 (eight) (C)
from 81 tо 90 points 9 (nine) (B)
from 91 tо 100 points 10 (ten) (A)
19. Signature and final exam For a signature - presence of at least 7 (60%)
prerequisites lectures; For the final exam - scored at least 42
points on all grounds;

instruction
22. Literature
Required literature
1. Teodor T. Tulcinski, New public health NIP 2003
Elena A. Varavikova Studentski
zbor - Skopje
22.1.
2. Lence Mircevska, Donco Zdravstveno vospitanie Bitola 2006
Donev, Ilija Gligorov
3. D.Donev, G.Pavlekovi, Health promotion and Hans Jacobs
l.Z.Kragelj disease prevention publishing
company
22.2.
1. Course title Intrahospital infections
2. Code
4. Organiser of the study University Goce Delcev

department)
5. Leve of studies (first, second, third First cycle

cycle)
6. Academic year / Semester Second year / 7. Number of 2

forth semester Credits
8. Lecturer/Instructor Professor D-r Velo Markovski
10. Course objectives (competencies): To realize the seriousness of the intrahospital

infections as a huge public health problem and to understand the importance of the
control of the intrahospital infections; To know how to define and recognize the
intrahospital infections and the risk factors which influence or are dominant for their
appearing; To acquire knowledge and skills for control, suppression and prevention of
the intrahospital infections;
11. Course content:
1. Definition and meaning of the intrahospital infections

2. Need for epidemiological approach in the control of the intrahospital infections
3. Etiology of the intrahospital infections
4. Occurrence and transmission of the intrahospital infections
5. Types of intrahospital infections
6. Disinfection and sterilization
7. Medical waste and intrahospital infections
8. Prevention of intrahospital infections
9. Types of epidemiological supervision and control of intrahospital infections
10. Organizational placement and law regulative in the control of intrahospital
infections
11. The importance of team work and interdisciplinary approach in control of
intrahospital infections
12. Elements of the control of intrahospital infections
Skills for controlling intrahospital infections:
 Appropriate hands hygiene; Control of the hands hygiene of the health care
workers;
 Appropriate disinfection of the working surfaces and objects in the hospital
environment;
 Appropriate taking of a swab from nose, throat and wound;
 Appropriate processing / taking material for microbiological diagnoses from
patients with intrahospital infections;
 Being critical in defining and taking the materials for microbiological
diagnoses;
 Appropriate packing and transporting of the samples for microbiological
diagnoses;
 Procedures in case of occurrence / isolation of MRSA;
 Appropriate taking of material for air control in the hospital environment (
operation rooms, intensive care units);
 Group discussion – procedures and suggested measures for suppression
and prevention of the intrahospital infections in certain situations (according
to certain examples of intrahospital infections);
 Working in small groups/teams - procedures and suggested measures for
suppression and prevention of the intrahospital infections in certain
situations (according to certain examples of intrahospital infections);
 Filling a unified application for each patient with intrahospital infection;
 Defining incidence and prevalence rate of intrahospital infections
12. Course methodology: Lectures, group discussion methods, individual assignments,
seminar papers;

education
15.2. Practice (laboratory /

papers, teamwork
16. Other forms of activities 16.1. Project work 10hours
17.2. Seminar paper/project ( presentation: written and oral) 10 points
18. Grading system (points / grade) to 50points 5 (five) (F)
from51 to60points 6 (six) (E)
from61 to70points 7 (seven) (D)
from71 to80points 8 (eight) (C)
from81 to90points 9 (nine) (B)
from91 to100points 10 (ten) (A)
21. Method of monitoring the quality of Self evaluation

instruction
Annex No.3
1. Course title Introduction to clinical practice
2. Code

Faculty of Medical sciences

third cycle)
6. Academic year / semester 2012-2013 7. Number of 5

credits
V
8. Lecturer/ Instructor Prof. Nikola Kamcev

The purpose of this course is to familiarize students with theoretical and practical
knowledge in clinical practice. Studying this course, students will gain knowledge
about the basic types of laboratories, the behavior and personal protection in them.
They will learn about how to properly take blood, urine and fluid from patients
hospitalized and treated in clinical departments, to handle medical waste, and also to
master the ways of disinfection and sterilization. They will study the basic
characteristics of laboratory equipment and laboratory techniques to learn how to
safely and properly operate them.
The main task of this course is for students to acquire theoretical and practical
knowledge about personal safety and safe behavior in laboratory and clinical
departments. Also objects of study of this subject are plans for emergency situations
and emergency procedures as chemical, electrical and fire safety.
They need to learn how to assess the health status of patients and to determine the
vital parameters (heart rate , arterial pressure , breathing , to learn how to take
different biological materials for analysis , and to learn the basic methods of care and
nutrition patients).
11. Course content:
1. History of clinical practice

2. Types of laboratory facilities according to biosafety
3. Microbiological risk assessment
4. Ethic rules
5. Projecting of laboratory and laboratory equipment
6. Clinical laboratory techniques for taking biological material for analysis
7. Medical waste handling
8. Accreditation and certification
10. Contingency plans and emergency procedures
11. Transport of infected material
12. Checklist for biosafety
13. Transmission of infectious agents
14. Ethical aspects related to blood transfusion
15. Clinical laboratory diagnosis of clinical conditions
12. Course methodology: theoretical work, interactive lectures, individual rasks, seminar
paper

teaching,
e-teaching

exercises,

work


oral)
A 8 (eight) (C)
19. Signature and final exam Attendance and activity on lectures and
prerequisites tutorials, satisfactory colloquia

instruction
22 Literature
1. Проф. Д-р Авторизирани авторот 2013

Никола предавања
Камчев
22. Literature
Required literature
1. C. Glen Mayhall Hospital Epidemiology Philadelphia 2004
22.1. and Infection Control, , USA

Third Edition,
2.
3.
22.2.
Annex No.3
1. Course title Introduction to infectious diseases
2. Code


third cycle)
6. Academic year / semester 2012-2013 7. Number of 4

credits
VI
8. Lecturer/ Instructor Velo Markovski,Phd
To master the basic elements of diagnosis, therapy and prophylaxis of infectious

diseases.
11. Course content:
1. Infection, infectious disease (basic features), temperature, species and regulation

2. Principles of diagnosis, therapy and prevention of infectious diseases
3. Fundamentals of Immunology of Infectious Diseases
4. Fundamentals of gastrointestinal infections; dehydration
5. Epidemiological and clinical features of hepatitis
6. Viral rush diseases: varicella-zoster, measles, Rubeola, Flu
7. Parotitis epidemic. Mononucleosis
8. Respiratory infections
9. Characteristics of zoonoses
10. Infectious diseases of the CNS
11. HIV infection
12. Acceptance of patient with an infectious illness and accommodation in isolation

13. Adequate protection of medical personnel and disposal of infectious waste
14. Sampling of biological material for examination
15. Microbiological and serological analyzes in infectology
16. Diagnostic and therapeutic protocol for infectious diseases
17. Registration and check of an infectious diseases
18. Treatment of patient with hepatitis
19. Treatment of the patient with rush of infectous origine
20. Lumbar puncture
12. Course methodology: theoretical and practical work
15. Forms of teaching 15.1. lectures / theoretical 30 hours

activities teaching,
e-teaching

exercises,
work

oral)
A 8 (eight) (C)
19. Signature and final exam Attendance and activity on lectures and
prerequisites tutorials, satisfactory colloquia

instruction
22. Literature
1.
Required literature
22.1.
1. Authorized 1. Faculty of
lecture- Medicine-
University
Goce
Delchev-
Stip
2. Infectious Faculty of
Diseases(selected Medicine, Skopje
chapters),
3.

1. Course title Clinical and toxicological analysis
2. Code

Faculty of Medicine

third cycle)

credits
8. Lecturer/ Instructor Associated professor PhD Vesna Kostik
10. Course objectives (competencies): Basic principles of toxicological investigation of

certain groups of poisons, their physical and chemical properties, toxicological
importance, toxicity for humans, antidotes, symptoms and medical treatment,
biotransformation in human body, investigation of certain group of poisons in biological
fluids and tissues and other types of materials, biomarkers of poisons and their
determination in biological fluids and tissues.
11. Course content:
1. Toxicology – Division of toxicology, types of toxicological approaches, definition

of term “poison”, toxic and lethal dose, classification of poisons, ration between
dose and effect, characteristics of exposure to toxic substances, ways of
exposure, ways of ingestion of poisons and their impact on human body,
metabolism of poisons in human body, excretion of poisons from human body,
development of tolerance to poisons, accumulation of poisons, classification of
poisonings, antidotes. Performance of toxicological analysis (common rules and
safety rules in toxicology analysis, purity of reagents), group of gases: carbon
monoxide, carbon dioxide, chlorine, hydrogen sulphide, cyan hydrogen.
2. Volatile organic compounds: toxicological importance, physical and chemical
properties, mode of action, symptoms of poisoning, the importance of laboratory
tests in diagnosis of type of poisoning, toxicity of organic solvents, specific
effects of organic solvents, ethanol, methanol, acetic acid, aliphatic
hydrocarbons: hexane, carbon disulphide, dichloromethane, chloroform,
tetrachlorethane, trichloroethylene.
3. III group of poisons (mineral poisons): Types of mineralization of organic
material: dry mineralization, mineralization using low temperatures using
oxidising agents (wet mineralization), and other methods of mineralization
(mineralization using microwaves).
4. Arsenic: Toxicological importance, types of poisonings, toxicologically important
arsenic compounds – arsenic trioxide, arsenates, arsenic hydrogen, arsines,
organic arsenic compounds, toxicity of organic compounds, symptoms of
poisoning, impact on inner organs, antidotes, investigation – classical
techniques, modern techniques for arsenic determination of arsenic in various
types of matrixes (FIAS), interpretation of the results.
5. Antimony: Toxicological importance, physical and chemical properties,
toxicologically important compounds, toxicity, symptoms, antidotes,
determination, interpretation of the results.
6. Mercury: Toxicological importance, physical and chemical properties,
toxicologically important compounds, toxicity, symptoms, antidotes, protection
of professional poisonings, determination in different types of matrixes,
interpretation of the results.
7. Lead: Toxicological importance, physical and chemical properties,
toxicologically important compounds, accidental and professional poisoning,
toxicity, symptoms, antidotes, protection of professional poisonings,
determination in different types of matrixes, interpretation of the results.
8. B. Mineral poisons which are analysed without prior mineralization of organic
material: alkaline compounds, potassium chlorate, sodium chlorate, nitrites,
fluorides, strong mineral acids – sulphuric acid, nitric acid, hydrochloric acid
(toxicological importance, physical and chemical properties, toxicologically
important compounds, toxicity, symptoms, antidotes, protection of professional
poisonings, determination in different types of matrixes, interpretation of the
results).
9. IV group of poisons which are isolated from organic material with liquid-liquid
extraction – Common methods of extraction.
10. A. Poisons which are isolated from acid solutions: glycosides (digitalis
glycosides, , barbiturates, salicylic acid and its compounds, oxalic acid,
dinitrophenol, picric acid (toxicological importance, physical and chemical
properties, toxicologically important compounds, toxicity, symptoms, antidotes,
determination in different types of matrixes, interpretation of the results).
11. B. Poisons which are isolated from alkaline solution: opium alkaloids, morphine
and morphine derivates, atropine, hyosciamine, scopolamine, cocaine,
synthetic local anaesthetics, aconitine, veratrine, physostigmine, nicotine,
coniine, colchicines, pilocarpine, alkaloids of secale cornutum, solanine
(toxicological importance, physical and chemical properties, toxicity, symptoms,
antidotes, determination in different types of matrixes, interpretation of the
results).
Lectures (theoretical teaching), theoretical and practical exercises, preparation of
independent seminar paper

teaching,
e-teaching

exercises,

work
16.3. Homework 55hours


oral)
19. Signature and final exam Attendance and at leat 42 points from pre-exam
prerequisites activities

instruction
22. Literature
Required literature
1. Milan Jokanovic Toxicology Elit, Medicina, 2001

Belgrade
2. R. Dreisbach, Intoxication, Savremena 1989

W.Robertson Prevention, Administracija,
Diagnosis and Belgrade
Medical Treatment
22.1. 3. Stanley E. Manahan Toxicological Lewis 2003

chemistry and Publishers
Biochemistry
A CRC Press
Third edition Company
Boca Raton
London New
York
Washington,
D.C.
1. Danica Prpic-Majic Toxicological and Medicinska 1985

chemical analysis kniga
22.2. Beograd-
Zagreb
2. Dr. Momcilo St. Toxicological chemistry University of 1962

Mokranjac Belgrade,
Faculty of
Pharmacy
Annex No.3
1. Course title Bromatology
2. Code


third cycle)

credits
8. Lecturer/ Instructor Associated professor PhD Vesna Kostik
10. Course objectives (competencies): Basic principles of bromatology (food chemistry,

classification of food, food products and drinking water, chemical composition of
food, food product and drinking water, analytical methods and techniques used in
food and water analysis.
11. Course content:
1. Bromatology – History of bromatology, definition, objectives of bromatology,

classification of food components, definition of food, classification of food.
2. Energetic value of food. Principles of rational human nutrition.
3. Water for human consumption.
4. Carbohydrates. Oils and fats
5. Proteins
6. Vitamins, Minerals
7. Meat and meat products, Fish Eggs
8. Milk and milk products Cheese
9. Grains
10. Fruits and fruit products
11. Vegetables and vegetable products
12. Honey
13. Coffee
14. Cacao
15. Tea
16. Sugar (sucrose)
17. Salt
18. Vinegar
19. Food Additives
20. Genetically modified food, Food contamination (chemical, microbiological,
radiological)
Lectures (theoretical teaching), theoretical and practical exercises, preparation of
independent seminar paper
13. Total available time 7 ЕCТS х 30 h= 210 h
14. Distribution of available time 45+45+15+25 +80 = 210 h
. Forms of teaching activities 15.1. lectures / theoretical 45

teaching,
e-teaching

exercises,

work
16. Other forms of activities 16.1. Project work 15
16.2. Individual work 25
16.3. Homework 80

oral)
19. Signature and final exam Attendance and at leat 42 points from pre-
prerequisites exam activities

instruction
22. Literature
Required literature
22.1. No. Author Title Publisher Year
1. Stanimirovic, S BROMATOLOGIJA 1970
1. Belitz, HD, Grosch, W. FOOD CHEMISTRY Springer 2004

22.2. Berlin, 3 Ed.
2. Coultate, TP FOOD: THE Royal Society 1995

CHEMISTRY OF ITS of Chemistry
COMPONENTS
Annex No.3
Course Programme - first cycle studies
1. Course title Laboratory safety
2. Code

program(unit or institute,
Goce Delcev University - Stip

6. Academic year / semester Fifth semester 7. Number of credits 4
8. Lecturer/ Instructor Assistant Professor Tatjana Ruskovska, PhD
9. Required prerequisite none

courses
Introduction and training for personal protection when working in the laboratory, risk
assessment and addressing the issues of safety and biological safety in laboratories.
11. Course content:
1. Types of laboratory facilities according to the biological safety

2. Microbiological risk assessment
3. Regulation of behavior
4. Designing laboratories and facilities
5. Laboratory equipment
6. Handling the waste
7. Accreditation and issuance of certificates
8. Laboratory techniques
10. Contingency plans and emergency procedures
11. Transport of infectious material
12. Reviewing a list of biological safety
Work in small groups, seminar paper, practical work, discussion, debate, individual work
15. Forms of teaching 15.1. Lectures - theoretical teaching 30 hours

activities
15.2. Exercises (laboratory, theoretical), 15 hours

seminars, teamwork

/grade)

19. Signature and final exam Attendance and scored at least 42 points from all pre-exam
prerequisites activities.

22. Literature
Required literature
22.1. 1. Nikola Kamcev Safety at work in the UGD 2010

laboratory
2. Danijela Janikevik Lectures 2013

Ivanovska

22.2.
1. WHO Biosafety manual WHO 2004
2. JUAT Rules of accreditation JUAT 2002

Annex No.3
1. Course title Clinical microbiology
2. Code
4. Organizer of the study University “Goce Delcev”


third cycle)
6. Academic year / semester 2013-2014 / VI 7. Number of 4

credits
8. Lecturer/ Instructor Ass. prof. d-r Vaso Taleski, MD, D-r Sc.
Basic aim of the course programme is to introduce and enable students to acquire
theoretical, practical knowledge, skills and competences in field of microbiology.
11. Course content:
1. Introduction to history and development of microbiology as a science,

significance of microorganisms. Classification of bacteria, taxonomic
categories, nomenclature, size, shape and disposition of bacteria
2. Morphology and structure of bacterial cells: capsule, cell wall, cytoplasmic
membrane, cytoplasm and cytoplasmic inclusions, fimbrae and pili, flagellum,
bacterial spores, bacterial movement. Conditions for growth and multiplication,
growth phases, bacterial colonies
3. Chemical composition of bacteria, metabolism, mechanism of bacterial feeding,
metabolism of energy
4. Metabolism of nucleic acids. DNA replication. Nucleic acids decomposition.
Bacterial genetics. Bacterial phenotype and genotype variations. Gene transfer
5. Spreading of microorganisms. Associations of microorganisms. Pathogenicity
and virulence. Infections and infective diseases. Nonspecific and specific
immunity in humans. Immunotherapy and immune-prophylaxis.
6. Sterilization and disinfection. Antibiotics and chemiotherapeutics.
Microorganism’s resistance toward antibiotics. Side effects of
chemiotherapeutics.
7. Aerobic and anaerobic Gram positive and negative cocci.
8. Gram negative rods. Gram positive rods: sopreforming and non-sporeforming
9. Spiral bacteria. Rickettsia. Mycobacteria. Actinomyces,Nocardia
10. Morphology, structure, classification and multiplication of viruses. Importance of
viral infections
11. Most important DNA and RNA viruses
12. Morphology, structure, classification and multiplication of fungi. Morphology,
structure, classification and importance of parasites
13. Principles of safety in microbiological laboratory. Sampling, packaging and

delivering samples for microbiology testing
14. Microscope and microscopic examinations of microorganisms (light
microscope, fluorescence microscope, electron microscope). Staining of
microorganisms (Gram, Giemsa, Ziehl-Neelsen)
15. Culture media and bacterial cultivation. Identification of bacteria (classical
biochemical reactions, automatic systems for identification)
16. Antibiotic susceptibility testing of bacteria/antibiogram (classical diffusion and
dilution methods, automatic systems, E-test). Hemocultures
17. Microbiological diagnosis of wound infections and respiratory infections
18. Microbiological diagnosis of genital-urinary and sexually transmitted infections
19. Microbiological diagnosis of enteropathogens
20. Classical serologic reactions. Rapid tests
21. Immune-enzymes methods (ELISA, VIDAS)
22. Sterilization and Disinfection
23. Methods of viral diagnosis. Hepatitis markers. Diagnosis of HIV infections.
24. Diagnosis of yeasts and parasites
Methods of oral and visual learning/presentations and practical work in the lab.
14. Distribution of available time 1+2+1 per week

teaching,
e-teaching

exercises,

work

oral)
17.3. Attendance and participation during lecturing 10 points
17.4 Attendance and participation during lab practical work 10 points

17.5 Final exam 30 points
19. Signature and final exam Requirements for signature: presence at

prerequisites lecturing and practical work.
Requirements for final exam: at least 42 points

from two colloquia, presence at lecturing,
practical lab work and seminar paper/project -
presentation. Colloquia are not conditionally
connected. For students with points over 37 and
less than 42, the professor could organize
additional colloquium with maximum of 10
additional points
21. Method of monitoring the quality of Student evaluation

instruction
Self-evaluation
22. Literature
Required literature
1. Greenwood D. Medical Project of the 17-

et all. microbiology Government of the edition,
Republic of Macedonia,
2006,
for translation of
vocational and scientific Transla
books ted in
2011
2. Institute of Microbiology
and parasitology,
Panovski N. et Medical
Medical faculty Skopje.
all. microbiology
2011
Guest / invited - Genera
22.1. author: Vaso l part
Taleski
3. Institute of Microbiology
and parasitology,
Panovski N. et Medical
Medical faculty Skopje.
all. microbiology
2011
Guest / invited - Special
author: Vaso part
Taleski
4. Jawetz, “Medical The McGraw-Hill 24th

Melnick, & Microbiology” Companies ed.,
Adelberg 2007

1. Milena “Handbook on Institute of Microbiology

Petrovska et all. medical and parasitology,
5th ed.
microbiology Medical faculty Skopje,
and 2010
parasitology”
2. Vaso Taleski “Microbiology” Authorized 2008

presentations
Annex No.3
1. Course title Clinical biochemistry
2. Code

department)

third cycle)
6. Academic year / semester Third year / Sixth 7. Number of

semester credits
8. Lecturer/ Instructor Prof. Tatjana Ruskovska
Learning the work and methods in the clinical biochemistry laboratories, and principles
for good laboratory practice in laboratory medical diagnostics.
11. Course content:
1. Theoretical basics of clinical enzymology 1.

2. Theoretical basics of clinical enzymology 2.
3. Diagnostic significance of AST, ALT, CK and amylase.
4. Diagnostic significance of γ-GT, LDH and alkaline phosphatase.
5. Microelements, macroelements and acid-base balance 1.
6. Microelements, macroelements and acid-base balance 2.
7. Enzyme and immunochemical methods: theoretical basics.
8. Hormones and tumour markers: methods for their determination and diagnostic
significance.
9. Urine analysis: chemical examination.
10. Urine analysis: examination of the sediment 1.
11. Urine analysis: examination of the sediment 2.
12. Hematology analyzers with threefold and fivefold differential blood test.
1. Determination of the activity of AST and ALT in serum.

2. Determination of the activity of amylase in serum and urine.
3. Determination of the concentration of calcium and phosphorus in serum and
urine
4. Determination of iron concentration and TIBC in serum.
5. Determination of the concentration of sodium and potassium in serum and
urine.
6. Introducing of the principle of the gas analysis method.
7. Determination of cortisol with EIA method.
8. Introduction with the automatic immunohemiluminiscent analyzer functions and
work.
9. Making a complete urine examination 1.
10. Making a complete urine examination 2.
11. Making a hemogram with automatical hematology analyzer.
12. Final exercise.
- Interactive teaching: Lectures in large groups with discussions and engaging

the students.
- Multimedia teaching.
- E-learning.
- Individual consultations with students and consultations in groups.
- Practical laboratory exercises in small groups.
- Auditoria exercises.
- Visiting clinical and biochemical laboratory and demonstrating the operation of
automatic biochemical analyzer.
- Final exercise.
14. Distribution of available time 24 hours of theoretical tuition+24 hours of

practical tuition+12 hours of other forms of
activities / per week

teaching,
e-teaching

exercises,

work

oral)

19. Signature and final exam Attendance and at least 42 points acquired from
prerequisites pre-exam activities

instruction
22. Literature
Required literature
1. Carl A. Burtis, Edward TIETZ, Fundamentals Saunders, 2008

R. Ashwood, David E. of Clinical Chemistry, Elsevier
Bruns 6th edition
2. Рушковска Татјана Clinical biochemistry Script for 2010
22.1 intern use
.
3. Мајкл Л. Бишоп, Clinical chemistry ( Prosvetno 2009
Едвард П. Фоди, principles, procedures delo, Skopje
Лари Е. Шоеф and correlations ) –
Translated
Fifth edition
book –
Project of the
Government
- Republic of
Macedonia
4. Александар К. Medical biochemistry Translated
Брауни, Џон К. book –
Керноан Project of the
Government
- Republic of
Macedonia
22.2 Supplementary literature
. No. Author Title Publisher Year

Annex No.3
1. Course title Clinical transfusiology
2. Code


third cycle)
6. Academic year / semester Third year / 7. Number of 4

Sixth semester credits
8. Lecturer/ Instructor Prof. D-r Nikola Kamcev
Gaining theoretical and practical knowledge in the field of clinical transfusion which
will allow to overcome the basics of genetics and immunology in transfusion, blood
group systems and their clinical significance, receiving blood products and their
clinical use, treatment with blood and blood products in surgery, gynecology, neonatal
period, a syndrome of massive transfusion, transfusion of apheresis application and
the basic principles of the haemostasis laboratory and clinical diagnosis of
hemorrhagic and thrombotic diseases, their prevention and treatment as well as
transfusion aspects in tissue and organ transplantation.
11. Course content:
1. Basics in clinical transfusion

2. Basics of genetics and immunology in transfusion
3. Blood group systems and their clinical significance
4. Immunoserology in clinical practice
5. Blood and blood products therapy.
6. Diagnosis of haemorrhagic syndrome.
7. Chemotherapy in patients with impaired haemostasis
8. Massive transfusion syndrome
9. Aspects of blood transfusion in neonatal period
10. Transfusion of apheresis
11. Cryoconservation of blood cells
12. Transplantation of stem cells and HLA system

the students.
- E-learning.

teaching,
e-teaching

exercises,
work

oral)
19. Signature and final exam Attendance and at least 42 points acquired
prerequisites from pre-exam activities

instruction
22. Literature
Required literature

1. Vukman Gligorovikj, Clinical transfusion Belgrade 1998
Bela Balint
2. Milenka Blagoevska Transfusion Skopje 2011
3. Prof. D-r Nikola Kamcev Authorized lectures 2012

1. Course title Methodology of scientific research in Health Care
2. Code
4. Organiser of the study Faculty of Medical Sciences

Department of Public Health and Health Protection
department)

cycle)
6. Academic year / Semester Fourth semester 7. Number of ECTS 4

credits
8. Lecturer/Instructor Professor D-r Gorgi Sumanov
10. Course objectives (competencies): Acquiring knowledge for the basic methods and
methodology of scientific research; Using biomedical databases and practicing evidence
based on medicine; Acquiring skills for doing researches; Implementation of a research
project; Rules for preparation of a manuscript for publication of the results of a scientific
research; Rules and preparation for a successful presentation of a scientific labour in the
form of oral or poster presentation.
11. Course content:
1. Basic terms of science and scientific method

2. Ethics and responsible behavior in the scientific research
3. Epidemiological methods in the scientific research
4. Types of researches – Design of studies
5. Using biomedical databases and practicing evidence based on medicine
6. Strategies for searching literature
7. Planning and implementation of scientific research
8. Scientific labour – classification of the papers
9. Parts of scientific labour
10. Preparing for manuscript and publication
11. Quoting references
12. Writing style and presentation of the scientific labour
1. Ethics in the scientific research: case reports and discussion

2. Internet research – using biomedical databases
3. Strategies for searching literature
4. Critical analyses of a paper (example from published papers)
5. Planning a research
6. Ways of collecting information - constructing a questionnaire
7. Project assignment for a scientific research project for a given hypothesis - small
groups work
8. Presentation of the project assignments– critical analysis
9. Presentation of the project assignments– critical analysis
10. Independently making an abstract from published papers (in extenso)
11. Presentation of abstracts – critical analysis
12. Oral/Poster presentation of the scientific labour
12. Course methodology: Lectures, exercises, group discussions methods, individual
assignments, seminar papers, presentation of scientific papers;
14. Allocation of the available time 2+1+1

education
15.2. Practice (laboratory 15 hours

papers, teamwork

17.2. Seminar paper/project ( presentation: written and oral ) 10 points
18. Grading system (points / grade) tо 50points 5 (five) (F)
from51 tо 60points 6 (six) (E)
from61 tо 70points 7 (seven) (D)
from71 tо 80points 8 (eight) (C)
from81 tо 90points 9 (nine) (B)
from 91 tо 100points 10 (ten) (A)
21. Method of monitoring the quality of Self evaluation

instruction
Annex No.3
1. Course title Nuclear medicine
2. Code


third cycle)
6. Academic year / semester Third year / Fifth 7. Number of 4

semester credits
8. Lecturer/ Instructor Doc. D-r Zdenka Stojanovska
11. Course content:
1. Physical basics of nuclear medicine.

2. Basics of radiopharmacy.
3. Nuclear and medical investigations in haematology.
4. Nuclear and medical investigations in cardiology.
5. Nuclear and medical investigations in nephrology.
6. Nuclear and medical investigations in GIT system.
7. Nuclear and medical investigations in hepatobiliary system
8. Nuclear and medical investigations in endocrinology.
9. Nuclear and medical investigations in neurology and psychiatry.
10. Nuclear and medical investigations in oncology
11. Therapeutic application of radionuclides.

the students.
- E-learning.
- Practical laboratory exercises in small groups.

- Auditoria exercises.
- Visiting clinical and biochemical laboratory and demonstrating the operation of
automatic biochemical analyzer.
- Final exercise.
14. Distribution of available time

teaching,
e-teaching

exercises,

work


oral)

instruction
22. Literature
Required literature
1. O. Vaskova, S. Miceva Fundamentals of Skopje 2008

Ristevska, D. Pop Nuclear medicine
Gjorcheva, D.
Miladinova, S.
Loparska, E. J.
Ivanovska
Annex No.3
1. Course title Immunological laboratory techniques
2. Code


third cycle)
6. Academic year / semester Third year / 7. Number of 4

Sixth semester credits
8. Lecturer/ Instructor Prof. D-r Darko Bosnakovski
Introduction to basics of laboratory techniques in immunology.
11. Course content:
1. Introduction to Immunology - immune system , types of immunity

2. Antigens, antibodies (immunogenicity and antigenicity), structure, classes and
subclasses, interactions.
3. Methods of separation of immune complexes, Methods of precipitation - gel ,
radial immunodiffusion
4. PAGE- electrophoresis, western blot
5. Methods of direct and indirect immunofluorescence
6. ELISA and RIA
7. Methods of selective separation of cells - filtration through cotton , separation
by density gradient
8. FACS
9. Agglutination methods - direct and indirect Coombs test
10. Determination of blood groups
11. Monoclonal antibody - methods of obtaining and applying
12. Labelling of antibodies for diagnosis and therapy of malignant diseases

the students.
- E-learning.
14. Distribution of available time 2 + 1+ 2

teaching,
e-teaching

exercises,

work

oral)

instruction
22. Literature
Required literature
1. Richard A. Goldsby, Immunology Translated 2012

Thomas J. Kindt, book from
Barbara A. Osborne, Government
Janis Kuby of R.
Macedonia
Annex No.3
1. Course title Evaluation of instruments, methods and reagents
2. Code


third cycle)

credits
9. Required prerequisite courses Prerequisite for entering the subject 1: Listened

to Analytical chemistry 1 and 2, Instrumental
pharmaceutical analysis
The aim of the study of subject Evaluation of instruments, methods and reagents in the
Faculty of Medical Sciences in Study Programme of Pharmacy is to explain the
principles of the spectrophotometric, electrochemical and thermo analytical methods
and the principles of validation of their use. To explain the principles of the system of
validation of iinstruments, methods and reagents and to present some practical cases.
11. Course content:
Quality control of analytical methods. Theoretical basis and analytical importance of

spectrophotometric, electrochemical and thermo analytical methods for analyses in
general analytical and biochemical practice.
Spectroscopic methods for analyses, introduction, UV-Vis spectrophotometry, AAS,
calibration of instruments and validation of methods. Electrochemical methods,
introduction, electrogravimetry, ion selective electrodes, calibration of instruments and
validation of methods. Thermo analytical methods, introduction, thermo gravimetric
analyses, differential calorimetric analyses, calibration of instruments and validation of
methods.
Chromatographic (HPLC, GC, TLC, HPTLC, gel and ion chromatography SFC)
methods, introduction, calibration of instruments and validation of methods.
Reagents, pharmacopoeia procedures for standardization of reagents and volumetric

solutions.
Cases of quantitative analyses of nonorganic/organic compounds in simple samples,

pharmaceutical and complex biological samples using electrogravimetry, potentiometric
titrations, UV-Vis spectrophotometry, AAS, calorimetric analyses or chromatography.
Comparison and validation of methods. General pharmacopoeia reagents, making,
labeling and storing.
Lectures, practical laboratory work, individual assignments, group discussion methods

teaching,
e-teaching

exercises,

work
16.2. Individual work hours
16.3. Homework hours

oral)
19. Signature and final exam The student is responsible to actively monitor all
prerequisites the activities with which it wins points, which
include participation in the ongoing review of
knowledge to get signature and to obtain
necessary number of points to be able to
takethe final exam.
Criteria for passing:
• The Assessment method is based on the

cumulation of points won: lectures, exercises,
colloquiums and paper work;
• colloquia are independent of each other, i.e.

taking one is not a prerequisite for taking the
other colloquium;
• The final exam is also not dependent on the

midterm, they are not a requirement for passing
the final exam, but the total number of points
scored, which should not be less than 42 points;

arrange additional colloquium, when there is
sufficient number of candidates

instruction
Self-evaluation
22. Literature
Required literature
22.1. 1. Habibur Rachman Applications of Lap Lambert 2012

Analytical Academic
Techniques/Methods of Publishing
Drug Analyses
2. European Council of 2008
Pharmacopoeia, 6th Europe,
Edition, Strasbourg,
3. Б. Ѓорѓеска Презентации од
предавања и вежби
1. Ashutosh Car Pharmaceutical drug New Age 2005

analysis International
Ltd.
22.2.
2. D. G. Watson, Pharmaceutical Churchill 1999
analysis, A Textbook Livingstone,
for Pharmacy Students Oxford,
and Pharmaceutical
Chemists,
3.

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Study Program: MEDICAL LABORATORY TECHNICIANS

FIRST YEAR - I SEMESTER

UGD102712 Sports and recreation* 0 0+0+2

FIRST YEAR - II SEMESTER

Pathology 6 2+3+1 180

Pharmacology 4 2+1+1 120

Introduction to internal medicine 6 3+2+1 180

Cell biochemistry 5 2+2+1 150

SECOND YEAR - IV SEMESTER

Analytical chemistry 5 2+2+1 150

Introduction to transfusiology 5 2+2+1 150

Medical histology 4 2+1+1 120

Biostatistics 4 2+1+1 120

Instrumental analysis 5 2+2+1 150

Elective course group 1 2 2+0+1 60

THIRD YEAR – V SEMESTER

Code COURSE Credits Hours Overall workload

Introduction to clinical practice 5 2+1+1 150

Introduction to infectious diseases 5 2+2+1 150

Clinical and toxicological analyses 6 3+2+1 180

Bromatology 6 3+2+1 180

Laboratory safety 4 2+1+1 120

Elective course group 2 2 2+1+1 120

Clinical biochemistry 6 3+2+1 180

Clinical tranfusiology 4 1+2+1 120

Professional practice 4 0+4+0 120

Elective course group 3 4 2+1+1 120

Bachelor thesis 8 240

LIST OF ELECTIVE COURSES

Public health 2 2+0+1 60

Intrahospital infections 2 2+0+1 60

SECOND YEAR –V SEMESTER (Group 2)

Methodology of scientific research 4 2+1+1 120

THIRD YEAR- VI SEMESTER (Group 3)

Annex No.3 Course Programme- first/second/third cycle studies

1. Course title Anatomy

3. Study programme Medical laboratory technicians

4. Organizer of the study programme(unit or Faculty of Medical Sciences

5. Level of studies (first, second and third First cycle

6. Academic year / semester First 7. Number of 7

8. Lecturer/ Instructor Prof. Svetlana Jovevska PhD

9. Required prerequisite courses

10. Course objectives (competencies):

Introduction to anatomy as morphological science, mastering of professional

11. Course content:

1. Introduction to osteology and anatomy, types of bones, bone components, technical

12. Course methodology:Interactive classes, individual consultations with students

13. Total available time 7 ECTS х 30 hours = 210 hours

14. Distribution of available time 45+45+15+ 15+90

15. Forms of teaching activities 15.1. lectures / theoretical 45 hours

15.2. theoretical and practical 45 hours

e-exams, seminars, team

16. Other forms of activities 16.1. Project work 15 hours

16.2. Individual work 15 hours

16.3. Homework 90 hours

17. Assessment method

17.1. Tests / oral exams 70 points

17.2. Seminar paper / project (presentation: written and/or 10 points

17.3. Attendance and participation 20 points

18. Grading system (points / grade) up 50 points 5 (five) (F)

51 to 60 points 6 (six) (E)

61 to 70 points 7 (seven) (D)

71 to 80 points 8 (eight) (C)