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Journal of Midwifery & Women’s Health www.jmwh.

org
Review

Acupuncture and Acupressure in Labor


Judith M. Schlaeger, CNM, PhD, LAc, Elizabeth M. Gabzdyl, CNM, DNP, APN, Jeanie L. Bussell, PhD,
CEU
LAc, Nobuari Takakura, PhD, LAc, Hiroyoshi Yajima, PhD, LAc, Miho Takayama, PhD, RN, LAc,
Diana J. Wilkie, PhD, RN

Acupuncture and acupressure, 2 modalities of Traditional Chinese Medicine, are based on reducing pain and symptoms of disease through balanc-
ing yin and yang. Acupuncture and acupressure have been used in China for reduction of labor pain, labor augmentation, and other intrapartum
indications for more than 2 millennia. This article presents a review of the current literature that has addressed the effects of acupuncture and
acupressure on intrapartum events. Studies of acupuncture have demonstrated that acupuncture may reduce labor pain, the use of pharmacologic
agents, the use of forceps and vacuum-assisted births, and the length of labor. Studies that examined the effect of acupuncture on labor that is
induced or augmented for premature rupture of membranes have found that acupuncture may increase the degree of cervical ripening but does
not reduce the amount of oxytocin or epidural analgesia administration, nor does it shorten length of induced labor. Acupressure may reduce
labor pain and labor duration, but acupressure has not been found to increase cervical ripening or induce labor. There are insufficient studies
about acupuncture and acupressure and their effects on labor at this time, and there is need for further research. Areas of uncertainty include
efficacy, optimal point selection, best techniques, and length of time for point stimulation.
J Midwifery Womens Health 2016;00:1–17  c 2016 by the American College of Nurse-Midwives.

Keywords: acupressure, acupuncture, labor, labor augmentation, pain, persistent cervical lip, Shiatsu, Traditional Chinese Medicine, TCM,
Traditional Japanese Massage

INTRODUCTION needles made of stone were originally used for rudimentary


Acupuncture and acupressure have been practiced through- surgeries. It was observed that pressing these early needles
out China for more than 2 millennia, but only in the past against the skin on certain points on the body alleviated
several decades has the Western medical community begun to disease and/or pain at other locations.2 By 1600 bc (the
consider the merit of integrating these therapies. Integration Bronze Age in China), stone needles were replaced by bone,
of these therapeutic modalities may enable optimization bamboo, and bronze needles that were inserted into then
of an individual’s health and well-being. Acupuncture and known acupuncture points.2 Between 600 and 300 bc Daoist
acupressure may be used to reduce labor pain, and acupunc- practitioners in deep meditation noticed consistent patterns
ture may aid in cervical ripening, but neither acupuncture of energy movements that they meticulously recorded and
nor acupressure have been shown to be effective for in- are now known as meridians, which are the pathways that
duction and/or augmentation of labor. This article reviews move qi throughout the body.1
the history of acupuncture and acupressure, the theories of Acupuncture was used to treat women’s reproductive
Traditional Chinese Medicine (TCM), scientific mechanisms problems as well. Medical texts written during the Han
of acupuncture and acupressure, and findings of current dynasty (476-221 bc) that are still in use today include
studies that have evaluated the effectiveness of acupuncture acupuncture treatments for amenorrhea, irregular menses,
and acupressure for use in labor. We searched the literature hyperemesis, and threatened abortion.3 By 551 bc Confu-
with the goal of reviewing the highest-quality randomized cianism strongly influenced Chinese society and because of
controlled trials (RCTs) and meta-analyses on the use of the Confucian imperative to produce a son, the specialties
acupuncture and acupressure for 1) the reduction of labor of fertility and obstetrics became highly developed areas of
pain and 2) labor induction and/or augmentation. Chinese Medicine.4
In Japan, acupressure originated in the early 1900s as
BACKGROUND Shiatsu, from shi (finger) and atsu (pressure), and was first
described in the book Shiatsu Ho by Tenpeki Tamai. By 1957,
TCM is a system of Chinese medicine dating back at least 2000 Shiatsu incorporated meridian theory and the use of points.5
years. Acupuncture and acupressure are 2 of the therapeutic
modalities used in TCM. Theories of Traditional Chinese Medicine
The Theory of Yin and Yang is the basis of all TCM’s
History of Acupuncture and Acupressure
philosophies.3,6 The fundamental tenet is balance using the
The earliest evidence dates use of acupuncture to the Stone concept of complementary opposites. Yin is night, dark, cold,
Age approximately 3000 bc.1 Oral tradition asserted that feminine, inactive, quiet, inward, and toward the earth. Yang
is day, light, hot, masculine, active, loud, outward, and to-
Address correspondence to Judith M. Schlaeger, CNM, PhD, LAc, Uni- ward heaven. Health is viewed as a balance between yin and
versity of Illinois at Chicago, College of Nursing (M/C 802), Room 856, yang; the goal is to rebalance them.1,6 Qi is the vital energy
845 S. Damen Ave., Chicago, IL 60612. E-mail: jschlaeg@uic.edu found everywhere in the universe. Qi flows in every part of

1526-9523/09/$36.00 doi:10.1111/jmwh.12545 
c 2016 by the American College of Nurse-Midwives 1
✦ In Traditional Chinese Medicine (TCM), qi is energy that flows through the body’s 14 meridians and can be activated using
acupuncture and acupressure to restore balance and health.
✦ Acupuncture has many documented effects on the body; it reduces pain by activating mu opioid receptors and increasing
serum ␤ endorphins.
✦ Acupuncture and acupressure have been shown to have effects on women in labor, particularly for reduction of labor pain.
✦ Further research is needed that utilizes rigorous double-blind methods and uses standardized study protocols to advance
the science of acupuncture and acupressure use by women in labor.

the body via the meridians (Figure 1) which are the pathways which have anti-inflammatory functions and increase im-
that direct the flow of qi all around the body.7 The meridians mune system function of phagocytes, lymphocytes, T cells,
are compared to rivers in the body or branches on a tree. There B cells, and NK cells15,17,19 ; and 7) during labor, stimulation of
are 14 main meridians (Table 1, Figure 1). Qi flows within and release of oxytocin from the posterior pituitary.15,22 It is pre-
around the body and is in a constant state of transformation. sumed by researchers and those practicing acupressure that
Qi unites heaven and earth and the body in between.1,6 All the mechanisms of acupressure and acupuncture are similar.
individuals are born with qi and qi is also acquired. It is However, there is no direct evidence to support this tenet.
maintained and balanced by food, lifestyle, emotions, and
other influences. When the body fails to maintain balance, qi USE OF ACUPUNCTURE DURING CHILDBIRTH
is disrupted and disease may occur.6 The goal of acupuncture
and acupressure is to activate the qi, restoring balance to Acupuncture must be administered by a licensed acupunctur-
its flow through the body’s meridians, which restores a ist, and acupressure can be administered by a trained midwife
healthy and optimal state of being. Qi can be yin or yang. or other health care provider in any setting, both in and out of
Acupuncture needles are inserted into specific acupuncture the hospital. Acupressure can be practiced without a license,
points on the meridians to stimulate the circulation of qi and although training is advised for appropriate use. Clinical trials
blood. If qi or blood is deficient, acupuncture can strengthen have been conducted to assess the use of acupuncture for re-
(tonify) them; if they are in excess, acupuncture can reduce duction of labor pain, promotion of efficient second and third
stagnation or obstruction. Thus, the yin and yang of the body stages of labor, induction and augmentation of labor, cervical
become balanced, and pain and other symptoms are reduced. ripening, and rotating a breech presentation. Other uses that
There are 361 acupuncture points located throughout have not been scientifically evaluated include reduction of a
the body.7 Each point is assigned a number and carries persistent cervical lip, promotion of fetal descent, reduction
with it the name of the meridian along which it is located. of third-stage blood loss, rotation of a posterior presentation,
For example, GB21 is the 21st point along the gallbladder calming anxiety, reduction of nausea and vomiting in labor,
meridian. In addition to treating disease, acupuncture and reduction of maternal fatigue, and relieving a shoulder dys-
acupressure are used to reduce pain and facilitate routine tocia. Although many points may be used during pregnancy
homeostatic functions within the body.8–10 Acupressure and childbirth, the following points were selected for a focus
is pressure applied to acupuncture points. It has a similar in this article: GB 21, LI 4, BL 32, SP 6, BL 60, BL 67, LV 3, and
therapeutic effect as acupuncture, but it may not penetrate ST 36 (Table 2).
the meridians as deeply as acupuncture and therefore may
not be as effective for some applications.6,8,9 Acupressure is
Acupuncture for Reduction of Labor Pain
noninvasive and administered using firm pressure with the
fingers, knuckles, thumbs, or an appropriate acupressure tool. A Cochrane review published in 201110 (Table 3) examined
acupuncture from 9 randomized controlled trials (RCTs) for
pain management during labor. A variety of points were used,
Mechanisms of Action
including SP6, LI4, BL32, LV3, and ST36. When compared to
Acupuncture has been documented to have many ac- no treatment, acupuncture was associated with a reduction
tions throughout the body including 1) deactivation of in pain (standardized mean difference [SMD], –1.00; 95%
the limbic-paralimbic-neocorticol network system, which confidence interval [CI], –1.33 to 0.67). When compared to
among other things is responsible for the perception of placebo, women who had acupuncture reported increased
sensory pain11,12 ; 2) activation of mu opioid receptors13,14 ; 3) satisfaction with the method of pain treatment in labor
increase in serum ␤ endorphins15–17 ; 4) increase in adreno- (relative risk [RR], 2.38; 95% CI, 1.78–3.19); a reduction
corticotropic hormone (ACTH) release from the anterior in pain and use of pharmacologic agents (RR, 0.72; 95%
pituitary, thus decreasing pain15,18 ; 5) downregulation of M1 CI, 0.58-0.88); a reduction in pain (SMD, –0.55; 95% CI,
macrophages, Interleukin-1␤, Interleukin-6, Interleukin-18, –0.92 to –0.19); and a reduction in the duration of labor
and tumor necrosis factor (TNF), which have inflammatory (SMD, –1.06; 95% C.I, –1.74 to –0.38). Acupuncture was
functions15,17,19–21 ; 6) upregulation of M2 macrophages, also compared to a combined control group (no treatment

2 Volume 00, No. 0, xxxx 2016


Figure 1. 14 Traditional Chinese Medicine Meridians
Pathways that direct the flow of qi all around the body. They are compared to rivers in the body or branches on a tree.
Source: Deadman et al.7

Table 1. The 14 Traditional Chinese Medicine Meridians of the techniques for different time frames, additional evidence is
Body7 needed before clinical recommendations can be proposed. All
Large Intestine: LI 9 studies had a risk of bias as they were either not blind, only
Stomach: ST single-blind, or types of blinding were not clearly stated by the
authors.
Heart: HT
Subsequently, 2 studies published in 2011 evaluated
Bladder: BL the use of electroacupuncture for pain reduction in labor.
Pericardium: PC Electroacupuncture uses a mild electric current sent though
Liver: LV needles inserted into acupuncture points and is especially
good for the treatment of chronic pain conditions.19 MacKen-
Governing vessel: GV
zie et al conducted a single-blind RCT,23 in which 105 laboring
Lung: LU women were randomized into 4 groups: 1) a manual acupunc-
Spleen: SP ture group; 2) an electroacupuncture group (points used in
Small intestine: SI both groups were LI4, SP6, BL60, and BL67); 3) a sham group
Kidney: KD that either received manual acupuncture or electroacupunc-
ture (needles inserted shallowly next to LI4, SP6, BL60, and
San Jiao: SJ
BL67; and for the sham electroacupuncture group, needles
Gallbladder: GB were attached to an electric stimulation device that was not
Conception vessel: CV turned on); and 4) a usual care control group. Each group
received one treatment of 30 minutes’ duration. There was
no difference in epidural or parenteral analgesia rates in the
and placebo) in 2 studies and found to be associated with electro/manual group compared to the sham and usual care
a reduction in pain (SMD, –0.42; 95% CI, –0.65 to –0.18). group (RR, –1.18; 95% CI, 0.8 to –1.74). Conversely, in a Chi-
Finally, one study compared acupuncture to standard care in nese multicenter single-blind RCT,24 researchers examined
which the women in the acupuncture group had a reduction 350 women in labor randomized into electroacupuncture,
in the rate of forceps and vacuum-assisted births (RR, 0.67; sham electroacupuncture, and no treatment groups. One
95% CI, 0.46-0.98). Taken together, these findings support acupuncture point was treated once for a one-hour duration
the hypothesis that acupuncture can reduce pain in labor. at the end of latent phase of labor. Pain was rated on a 0 to
However, because the studies used different acupuncture 100 visual analog scale (VAS) at baseline, 15 and 30 minutes

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Table 2. Acupuncture Points
Name Indications Description Figure
Gallbladder This point has an action of release and descent, which is purported to Located at the crest of the trapezius muscle halfway between the
21 (GB21) facilitate fetal descent in active phase and second stage of labor.30 prominent spinous process of the seventh cervical vertebra (C7) and
The practitioner should palpate deeply on and around the point for the the tip of the acromion process of the scapula.7
most tender spot, in a slight indentation between muscles.

Large Stimulating this point is effective for reduction of labor pain and Located on the dorsum of the hand. It is most easily identified by
intestine 4 promoting stronger and/or more coordinated contractions.27,33–39 bringing the thumb and index finger close together and locating the
(LI4) highest place of the metacarpal bone on the radial aspect.7

Bladder 32 Indications include reduction of labor pain40 and induction of labor.31 Located at the second of the sacrum’s 8 foramen, which are arranged in
(BL32) 2 vertical rows of 4 foramen.7 To find this point, the last lumbar
vertebra and beginning of the sacrum should be located. At the top
of the median sacral crest (see figure) 4 fingertips (not pads) are
placed side by side as if making a guitar chord with the index finger
closest to the lumbar vertebra. Then the fingers should slide away
from the midline (laterally) until the 4 fingertips find the slight
depressions, which are the foramen. The tip of the middle finger
should be in the second sacral foramen (BL32).7 Deep pressure
should be applied to this point.

(Continued)

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Table 2. Acupuncture Points
Name Indications Description Figure
a
Spleen 6 One of the most important and frequently used points for obstetric Located on the medial aspect of the lower leg, 3 cun superior to the
(SP6) and gynecologic concerns. Indications include labor augmentation, medial malleolus (ankle bone) in a slight depression next to the
for irregular contractions to encourage efficient labor and reducing tibia.7 This is typically a tender point when located correctly.
a persistent cervical lip,35,41,42 reduction of labor pain,24,38,39,41–44
and reduction of the length of labor.39,41,42

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Bladder 60 It relieves lower back pain.38,44 Located on the foot. It is found in the depression between the lateral
(BL60) malleolus of the ankle and the Achilles tendon.

a
Bladder 67 Well known for its use for version of breech to a cephalic Located on the dorsum of the little toe at the corner formed 0.1 cun
(BL67) presentation.45–47 Together with LI4 it is used to reduce labor from where the lateral aspect and the base of the nail meet.
pain.34 It also stimulates uterine contractions.48

(Continued)

5
6
Table 2. Acupuncture Points
Name Indications Description Figure
Liver 3 (LV3) May soften the cervix49 and reduce pain in labor.44 Located on the dorsum of the foot in the hollow between the bodies of
the first and second metacarpal bones.

a
Stomach 36 Indications include relief of maternal exhaustion in labor and relief of Located on the lower leg, 3 cun below the kneecap in the hollow
(ST36) nausea and vomiting, hiccups, and belching.7 created when the knee is flexed, one fingerbreadth lateral to the crest
of the tibia.7

Source: Deadman et al.7


a
One cun is the width of the thumb, 2 cun is the distance from the middle joint to the tip of the index finger, and 3 cun is equivalent to the width of 4 fingers of one hand held together, at the level of the proximal interphalangeal joint. The
practitioner must adjust the size of the cun measurement according to the size of the person receiving acupressure. If the patient’s hand is larger, the cun will be larger; if the patient’s hand is smaller, the cun will be smaller and adjustments must be
made.

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Table 3. 2011 Cochrane Review Acupuncture for Treating Labor Pain
Author
Year
Country N Acupuncture Points Control Group Blinding Result(s)
Borup10 607 BL 23, 24, 25, 26, 31–34, 36, 60, CV20 Control group 1 (n = 144): No blinding reported Use of pharmacologic and invasive methods significantly lower in
2009 and sishencong, TENS acupuncture group (acupuncture vs traditional, P ⬍ .001;
Denmark ear points: uterus, shenmen, Control group 2 (n = 149): acupuncture vs TENS, P = .031).
endocrine, EX-HN3 yintang, LV3, Traditional analgesics Pain scores were comparable.
SP6, SP9, ST36, GB34, Acupuncture did not influence duration of labor or use of oxytocin.
HT7, PC6, LI10, LI11, LU7, LI 4 Mean Apgar score at 5 min and umbilical cord pH value significantly
higher among newborns in acupuncture group compared with
newborns in the traditional analgesic or TENS groups.

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Hantoushzadeh10 150 LI4 analgesia, BL32 back pain, BL60 Minimal acupuncture Participant: yes A VAS pain score in the study group was lower after 2 hours compared
2007 back pain, SP6 severe pain during Clinician: no to the control group.
Iran contractions, ST36 general pain, Outcome assessor: yes Active phase duration and oxytocin units administered were lower in
LV3 analgesia, GB34 cervical rigidity, the study group compared to the control group.
HT7 anxiety, nervousness Study group patients had greater willingness to receive acupuncture
again compared to the control group.

Huang10 324 Group 1: ST36, CV3, and CV4. 1) Electro-acupuncture group, No blinding reported VAS scores for the acupuncture group were better than TENS, and the
2008 Additional points for excess were n = 82 control groups, but not as good as the spinal-epidural analgesia
China BL32 and LV3 and for deficiency 2) TENS group, n = 82 group (P = .05)
were LI4 and SP6. 3) Control group (breathing),
Group 2: An acu-point nerve n = 81
stimulator, stimulated point with 4) Spinal-epidural analgesia
2/100 Hz of dilatational wave. group, n = 79

Martensson10 128 GV20, LI4 and SP6. Midwife’s choice Sterile water injection No blinding reported Sterile water injections yielded greater pain relief (P ⬍ .001) during
2008 of 4 to 7 local points from BL23, childbirth compared to acupuncture.
Sweden BL24, BL54, EX19, GB25-29 and Women in the sterile water group had a higher degree of relaxation
KD11. Needles were retained for (P ⬍ .001) compared to the acupuncture group.
40 min and stimulated every 10 min Women’s own assessment of the effects also favored sterile water
and were repeated as needed. injections (P ⬍ .001).
There were no significant differences in requirements for additional
pain relief after treatment between the 2 groups.

7
(Continued)
Table 3. 2011 Cochrane Review Acupuncture for Treating Labor Pain

8
Author
Year
Country N Acupuncture Points Control Group Blinding Result(s)
10 198 No blinding reported
Nesheim Point selection based on participant’s Control group 1: Study Meperidine was given to 11% of the acupuncture group, 37% of the no
2003 needs at BL32, GV20, BL60, BL62, midwife, no acupuncture acupuncture group (P ⬍ .0001), and 29% of the control group.
Norway HT7, LV3, GB34, CV4, LI10, LI11, Control group 2: Standard care The use of other analgesics was lower in the acupuncture group.
BL23, BL27, BL28, BL32, LI4, SP6, Patient satisfaction was high: 89 of 103 patients said they would want
PC6, 7, ST36. acupuncture during another labor.

Qu10 36 Electro-acupuncture at points LI4 and No pain relief No blinding reported The electro-acupuncture group was found to exhibit a lower pain
2007 SP6. intensity and a better degree of relaxation than the control group
China (P = .018, P = .031).
There was a significant difference in concentration of ␤ endorphins
and 5-HT (serotonin) in peripheral blood between the 2 groups at
the end of the first stage (P = .037, P = .030).

Ramnero10 100 GV20, yintang, LU7, BL 25-36, BL54, No acupuncture. Both No blinding reported Acupuncture treatment during labor significantly reduced the need of
2002 GB 25-29, CV 2, CV3, LI4, GB41, acupuncture and control epidural analgesia (12% vs 22%; RR, 0.52; 95% CI, 0.30–0.92).
Sweden LV3, BL60, KD3, SP6 groups had access to The acupuncture group had a significantly better degree of relaxation
conventional analgesia. compared with the control group (MD, –0.93; 95% CI, –1.66 to
–0.20).

Skilnand10 210 HT7, LU7, ST30, ST29, GB34, ST36, Minimal acupuncture Participant: yes There were significantly lower mean pain scores and significantly less
2002 SP8, SP6, KD3, GB41, LV3, GV20, Data collectors: yes need for pharmacologic analgesia in the study group compared with
Norway BL34, BL32, LI4, BL67, BL60 the control group.
The women given real acupuncture spent less time in active labor and
needed less augmentation than the control group.

Ziaei10 90 GV20, yintang, ST36, SP6, LI4, CV2, Control group 1 (n = 30): Participant: yes Fewer women needed augmentation of labor in the acupuncture group
2006 CV3 “pretend” acupuncture, Clinician: no than the 2 control groups.
Iran 6 points normally used for Analysts/outcome There were no significant differences among the groups in pain scores,
vaccinations and other assessors: unclear relaxation scores, duration of labor, rate of cesarean births, and birth
injections used. weight.
Control group 2 (n = 30): no
intervention.

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Abbreviations: TENS, transcutaneous electrical nerve stimulation; VAS, visual analog scale.
after the start of the treatment, and one, 2, 3, and 4 hours after In TCM, in order to locate acupressure points, a unit of
the needle was withdrawn. Mean (standard deviation [SD]) measurement called a cun (“soon”) is used. One cun is the
scores demonstrated a significant reduction in labor pain at width of the thumb, 2 cun is the distance from the middle joint
30 minutes after the start of the electroacupuncture treatment to the tip of the index finger, and 3 cun is equivalent to the
(76.0 [22.5]) in women who received electroacupuncture width of 4 fingers of one hand held together at the level of the
when compared to the women in the sham electroacupunc- proximal interphalangeal joint. The practitioner must adjust
ture treatment (81.6 [19.2], P ⬍ .05) and in women who the size of the cun measurement according to the size of the
received no treatment (85.4 [16.0], P ⬍ .05). Similarly, at both person receiving acupressure. If the patient’s hand is larger, the
2 and 4 hours after the needles were withdrawn, the women cun will be larger; if the patient’s hand is smaller, the cun will
who received electroacupuncture reported less pain (85.4 be smaller and adjustments must be made.7
[15.9] and 82.4 [17.1], respectively) compared to the women No adverse reactions or sequelae have been reported from
in the sham acupuncture group (89.4 [13.6], P ⬍ .05 and 91.5 any acupressure technique. Contraindications to the use of
[14.4], P ⬍ .05, respectively) or the no treatment group (92.2 acupressure in labor include fetal distress, uterine tachysys-
[12.1], P ⬍ .05 and 94.5 [8.8], P ⬍ .05, respectively). tole, and tetanic contractions. Maternal and fetal well-being
should be continuously assessed.

Acupuncture for Labor Induction Acupressure Studies for the Reduction of Labor Pain
A 2013 Cochrane review25 (Table 4) examined 14 RCTs of A Cochrane review10 published in 2011 (Table 5) that ex-
acupuncture for labor induction and cervical ripening that in- amined acupressure (4 trials) for pain management in labor
cluded 2220 women. The acupuncture points used included included 549 women. A variety of points were used, including
ST36, LV3, LI4, SP6, BL32, BL60, and BL67. There was greater SP6, LI4, and BL67. Compared to placebo, acupressure was
cervical ripening as evidenced by increased Bishop scores over associated with a reduction in pain (SMD, –0.55; 95% CI,
a 24-hour period in the acupuncture compared to the sham –0.92 to –0.19); a reduction in the duration of labor (SMD,
control group (mean difference [MD], 0.40; 95% CI, 0.11– –1.06; 95% CI, –1.74 to –0.38); and reduced cesarean rates
0.69) and usual care group (MD, 1.30; 95% CI, 0.11–2.49). (RR, 0.24; 95% CI, 0.11–0.54). In the studies that had a
No differences were found when the acupuncture group combined control group in which one had no treatment
was compared to the sham control groups and the usual care and one had placebo acupressure, the groups that received
groups with regard to the rate of oxytocin augmentation, need acupressure demonstrated a reduction in pain (SMD, –0.42;
for epidural analgesia, rate of forceps and vacuum-assisted 95% CI, –0.65 to –0.18) and reduced cesarean rates (RR,
births, rate of meconium-stained amniotic fluid, rate of Ap- 0.48; 95% CI, 0.22–1.04). All 4 studies had a risk of bias
gar scores less than 7 at 5 minutes, rate of perineal tears, and as they were either not blind, only single blind, or types of
length of labor. blinding were not clearly stated by the authors. These findings
A 2007 Norwegian unblinded RCT26 of 106 nulliparous support the postulate that acupressure may reduce pain in
women with premature rupture of membranes (PROM) at labor. However, additional evidence is needed before clinical
term were randomized 1:1 into an acupuncture and a control recommendations can be proposed.
group for augmentation of labor. Acupuncture points needled Three acupressure studies that assessed reduction of
depended on the patient presentation and included LI4, SP6, labor pain were published subsequent to the 2011 Cochrane
LV3, and BL32. There was no difference in 1) median times review. A 2014 single-blinded RCT27 evaluated 149 term
from PROM to active labor in the acupuncture (15 hours) nulliparous and multiparous women in active labor who were
compared to the control group (20.5 hours, P = .34); 2) me- evenly randomized to either acupressure (n = 50) or touch
dian duration of active phase in the acupuncture (6.6 hours) (n = 50) to LI4 bilaterally, or a usual care group (n = 49).
compared to the control group (5.5 hours, P = .35); 3) length Acupressure was applied with rotation and vibration for 60
of time from PROM to birth in the acupuncture (31.5 hours) seconds on and off for 30 minutes. The correct pressure was
compared to the control group (25.3 hours, P = .65); and 4) attained when the acupressurist’s nail bed turned white. The
rate of oxytocin augmentation if no labor within 48 hours post same cycle was used for the touch group. Women in all 3
ruptured membranes in the acupuncture (12.5%) compared groups rated their pain on a 0 to 10 VAS. Mean (SD) VAS
to the control group (17.0%, P = .53). A power analysis cal- scores demonstrated a reduction in pain in the acupressure
culated the minimum sample size to be 208 women, and thus, group at 30 minutes after intervention compared to the touch
this study was not adequately powered and may not have been and control groups (VAS score of 5.65 [1.87] vs 6.85 [1.89]
able to detect differences between the groups. and 8.18 [1.59], respectively). One hour after intervention,
the mean VAS scores demonstrated further difference in pain
relief (P = .11) in the acupressure group compared to the
USE OF ACUPRESSURE DURING CHILDBIRTH
touch and the control groups (VAS score of 6.51 [2.21] vs
In addition to acupuncture, RCTs have been conducted on the 7.64 [2.22] and 8.68 [1.54], respectively).
use of acupressure for reduction of labor pain, promotion of A 2014 Turkish single-blinded RCT28 included 100 nul-
efficient second and third stages, induction or augmentation liparous women randomized 1:1 to an acupressure and usual
of labor, and cervical ripening. Other uses that have not been care control group. Acupressure was administered to SP6 bi-
scientifically evaluated are the same as those not evaluated for laterally, from the beginning to the end of a contraction, start-
acupuncture. ing at 2 to 3 cm dilation for a total of 15 contractions, at 5 to

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Table 4. 2013 Cochrane Review of Acupuncture for Labor Induction
Author
Year
Country N Acupuncture Points Control Blinding Result(s)
25 89
Asher LI4, SP6, BL32, and BL54 Control group 1 (n = 30): Participant: yes for There were no statistically significant differences among groups for
2009 30 min treatment up to 5 times in sham acupuncture acupuncture groups time from enrollment to birth (P = .20), rates of spontaneous labor
United States 2 wks Control group 2 (n = 30): Prenatal care provider: (P = .66), or rates of cesarean births (P = .37).
standard prenatal care yes Rates of maternal and neonatal outcomes were not significantly
different.

Gaudernack25 100 LV3, ST36, CV4; additional points Standard care No blinding reported The duration of labor was significantly reduced (MD, 1.7 h; P = .03).
2006 according to TCM diagnosis The need for oxytocin infusion to augment labor in the study group
Norway There were a total of 8 points used. compared to the control group (odds ratio, 2.0; P = .018).
The needles were retained for Participants in the acupuncture group who needed labor induction
20 min. had a significantly shorter duration of active phase than the ones
induced in the control group (MD, 3.6 h; P = .002)

Gaudet25 16 Electro-acupuncture at SP6, ST43, and Sham acupuncture Participant: yes for There was a difference in intervention to birth interval of 62 hours in
2008 BL60 with manual stimulation of LI4. acupuncture groups favor of the treatment group.
Canada Patients received electro-stimulation on Obstetric provider: yes Women in the treatment group had shorter labors by a mean of 2 h and
4 points at 1-2 Hz for 30-45 min. 20 min.

Gribel25 72 Electro-acupuncture at LI4, ST36, LV3, Misoprostol No blinding reported There were no significant differences in labor frequency (P = .07) and
2011 SP6, BL23, and BL32. time of induction (P = .29).
Brazil All 6 points were stimulated every There was an absence of obstetric complications, a higher duration of
7 hours in 1 to up to 3 sessions in a labor (P = .036), and a tendency for higher patient satisfaction (P =
24-hour period of hospitalization. .046) in patients receiving acupuncture.
A higher frequency of cesareans (P = .014) and obstetric
complications (9.3%) were observed among control patients.

(Continued)

Volume 00, No. 0, xxxx 2016


Table 4. 2013 Cochrane Review of Acupuncture for Labor Induction
Author
Year
Country N Acupuncture Points Control Blinding Result(s)
Harper25 56 Acupuncture at LI4, SP6, BL31, Standard care No blinding reported Mean time to birth occurred 21 hours sooner in the acupuncture
2006 and BL32. group, but this difference did not reach statistical significance (P =
United States Electro-acupuncture at sacrum .36).
BL31 and BL32 with current at 2 Compared to controls, women in the acupuncture group tended to be
Hz for 30 min for 3 out of 4 more likely to labor spontaneously (70% vs 50%, P = .12) and less
consecutive days. likely to give birth by cesarean (39% vs 17%, P = .07).
Of women who were not induced, those in the acupuncture group

Journal of Midwifery & Women’s Health r www.jmwh.org


were more likely to give birth than the controls at any point after
enrollment (P = .05).

Long25 400 Auricular acupuncture was applied Rivanol only No blinding reported The average induction time in the auricular point pressing group was
1994 to points: Inner genitals, 10 hours earlier than in the control group.
China Sympathetic, Shenmen, Liver, The average stage of labor was shortened by 12 hours.
Yuanzhong and Adrenal gland, The amount of bleeding was reduced by 27.25 mL.
using a white mustard seed or a Injury to the placenta was decreased by 50%.
pill with adhesive plaster. The mental state of the patients in the auricular point pressing group
Rivanol (ethacridine lactate) was better than patients in the control group.
[antiseptic] was also supplied.

MacKenzie25 105 For manual and Control group 1: Sham Participant: no No difference between onset of labor in acupuncture compared to 2
2011 electro-acupuncture: LI4, SP6, manual acupuncture; no Acupuncturist: no sham groups and no treatment control group.
UK BL60, BL67. needle stimulation Intrapartum clinician: No difference in length of first stage (P = .29) in acupuncture group
For sham manual and sham Control group 2: Sham yes compared to 2 sham groups and the acupuncture group compared to
electro-acupuncture: shallow electro-acupuncture; the no treatment control group (P = .33)
insertion of needles adjacent to needles attached to wires No difference in length of second stage (P = .78) in acupuncture group
LI4, SP6, BL60, BL67 Control group 3: No compared to 2 sham groups and the acupuncture groups compared
treatment to the no treatment control group (P = .34)

(Continued)

11
12
Table 4. 2013 Cochrane Review of Acupuncture for Labor Induction
Author
Year
Country N Acupuncture Points Control Blinding Result(s)
25 50 SP6 No treatment No blinding reported
Martinez Patients who received acupuncture had significantly more frequent
2004 (P ⬍ .05) and greater intensity (P = .01) of uterine contractions than
Philippines the controls.
There was a significant reduction in the interval of uterine
contractions after acupuncture treatment (P ⬍ .05).
Duration of uterine contractions was significantly prolonged
(P = 0.08).

Modlock25 125 BL67, LI4, SP6, GV20 Sham acupuncture (Park Participant: yes The primary endpoint was achieved in 7 women (12%) in the
2010 sham needle) acupuncture group and 8 women (14%) in the control group (P =
Denmark .79). Stratification for parity and fetal gender did not alter the results.

Rabl25 56 LI4 and SP6 Standard care Participants not blinded Cervical length in the acupuncture group was shorter than that in the
2001 control group on day 6 and day 8 after EDC (P = .04 for both).
Austria In the acupuncture group the time period from the first positive
fibronectin test to birth was 2.3 days, while that in the control group
was 4.2 days (P = .08).
The time period from EDC to birth was on average 5.0 days in the
acupuncture group and 7.9 days in the control group (P = .03).
Labor was induced in 20% of women in the acupuncture group (n = 5)
and in 35% in the control group (n = 7) (P = .3).
Overall duration of labor, and first and second stage of labor were not
different in the 2 groups.
In 56% of women who underwent acupuncture (n = 14) and in 65% of
controls (n = 13), oxytocin was used to augment labor (P = .54).

(Continued)

Volume 00, No. 0, xxxx 2016


Table 4. 2013 Cochrane Review of Acupuncture for Labor Induction
Author
Year
Country N Acupuncture Points Control Blinding Result(s)

Journal of Midwifery & Women’s Health r www.jmwh.org


25 553 Acupuncture
Romer ST36, SP6, GB34, BL67 Nonspecific acupuncture The mean (SD) duration of labor in patients receiving specific
2000 weekly for 36 weeks including GV20, PC6, participants blinded acupuncture, nonspecific acupuncture, and no acupuncture was 470
Germany HT7. (190), 536 (200), and 594 (241) min, respectively (P ⬍ .002, t-test).
Nonrandomized usual care The cervical maturation was more pronounced in the treatment group
group also assessed (relative Bishop score change 5.9 (1.3), 4.0 (0.9), and 3.6 (1.0) points,
respectively; P ⬍ .0001).
The cervical length change differed significantly among the groups
(15.9 (4.8), 9.8 (3.4), and 8.9 (3.3) mm, respectively).
The specific acupuncture group also was associated with a significant
increase in the rate of de novo funneling at the level of the internal os.

Tremeau25 128 CV2, CV3, CV4, LIV3, BL60, Control group 1: sham Participant blinding Bishop scores in the 3 groups after a 10-day interval show a significant
1992 GB34, ST36, LI4, SP6, BL67 acupuncture unclear progression of 2.61 points in the group treated with acupuncture
France Control group 2: usual care compared to 0.89 and 1.08 in the placebo and control groups.

13
14
Table 5. 2011 Cochrane Review of Acupressure for Treating Labor Pain
Author
Year
Country N Acupuncture Points Control Blinding Result(s)
10
Chung 127 LI4, BL67 1. Effleurage Participant: no No significant reduction in pain in latent phase or transition
2003 Over 20 min with 3-5 kg of 2. Usual care control Outcome assessor: yes There was a significant reduction of pain in active phase (acupressure
Taiwan pressure applied for 5 min 0.17 [1.7], effleurage 0.66 [1.66], control 0.81 [1.23]; P .041).

Hjelmstedt10 212 Acupressure at SP6 bilaterally Control group 1: light touch at Participant: unclear A reduction of labor pain was found in the acupressure group and was
2010 during contractions over a SP6 bilaterally during Clinician: no most noticeable immediately after treatment (acupressure group vs
India 30-minute period contractions Outcome assessor: yes standard care group P ⬍ .001; acupressure group vs touch group
Control group 2: standard care P ⬍ .001).

Kashanian10 120 SP6 during contractions for a Touch at SP6, performed by Participant: unclear The mean duration of active phase was shorter in the case group
2010 total acupressure time of same investigator, for same Clinician: no (252.37 [108.50] min vs 441.38 [155.88], P = .0001).
Iran 30 minutes duration of time Outcome assessor: yes Six patients (10%) in the case group and 25 patients (41.7%) in the
control group gave birth via cesarean (P = .0001).
The severity of pain in the case group was less than the control group
(5.87 [1.77] vs 6.79 [1.52], P = .003).
Twenty-five women (41.7%) in the case group and 38 women (63.3%)
in the control group needed oxytocin (P = .017).
The amount of necessary oxytocin in the case group was less than the
control group (73.33 [97.19] mL vs 126.6 [97.19] mL, P = .003).

Lee10 75 SP6 (n = 36) × 30 min Touch control (n = 39) × Participant: yes 30 minute post-treatment VAS was: acupressure 7.0 ± 1.8 and touch
2004 30 minutes outcome assessor: yes control 8.3 ± 1.8, P ⬍ .021); and 60 minute post treatment pain
Korea intensity (acupuncture 7.7 ± 1.5 and touch control 8.9 ± 1.7, P ⬍
.012)

Abbreviation: EDC, estimated date of confinement.

Volume 00, No. 0, xxxx 2016


6 cm dilation for a total of 10 contractions, and at 9 to 10 cm administering the acupressure. Pressure should be deep and
dilation for a total of 10 contractions. Pressure administered firm. Enough pressure should be used to stimulate the points.
was standardized at 3 to 5 kg pressure for each acupressure The point will most likely be tender to mildly painful. It should
cycle. Pain was rated on a 0 to 10 VAS. Median pain scores in be remembered that this is not massage or light touch.
the acupressure compared to the control group demonstrated
a reduction in pain in the latent phase (3.0 vs 4.0, P ⬍ .001),
DISCUSSION
active phase (7.0 vs 8.0, P ⬍ .001), and 2 hours postpartum
(2.0 vs 3.0, P ⬍ .001). It is difficult to evaluate the overall findings of the acupunc-
A 2012 Iranian single-blinded RCT29 included term nulli- ture and acupressure trials reviewed since there were no
parous and multiparous women who were stratified and ran- shared study designs, methodologies, or consistency of
domized to a block design in active labor at term. Fifty women acupuncture points used between studies. No apparent at-
received acupressure to LI4; 50 women received control touch tempts by investigators have been made to replicate any pre-
to LI4 for the duration of each contraction for a single session viously published RCTs on acupuncture or acupressure for re-
lasting 20 minutes. Pain was rated on a 0 to 10 VAS; scores duction of labor pain or induction/augmentation of labor. No
were obtained at baseline, immediately after, 20 minutes after, 2 trials tested the same points, retained needles for the same
and hourly until birth. There was a significant reduction in duration, or used the same acupressure techniques. Only 2
mean (SD) scores in the acupuncture group immediately and trials25 that examined the use of acupressure for the reduc-
20, 60, and 120 minutes post treatment (5.4 [0.81], 6.5 [0.89], tion of labor pain were consistent in the manner in which they
7.1 [1.6], 8.6 [0.75], respectively), compared to the control quantified and applied the same amount of pressure with each
touch group (6.7 [1.4], 8.3 [1.1], 8.9 [2.0], 9.8 [0.38], respec- acupressure cycle. Thus, clinical practice guidelines cannot be
tively, P ⬍ .001). There was a significantly shorter active phase developed until standardized study protocols are devised that
(2.4 [0.8] vs 3.1 [1.1] hours respectively, P ⬍.001) and second offer investigators a substrate for implementing consistent re-
stage (20.5 [16.4] vs 28.5 [20.1] minutes respectively, P ⬍ .08). peatable acupuncture and acupressure interventions that can
be tested in future trials.
Another limitation is that all studies had a risk of bias
Acupressure Studies for Labor Induction
for blinding. RCTs that compared acupuncture to a usual care
Two 2015 RCTs used acupressure for induction of labor. One group were at high risk for bias because the women were not
RCT from the United Kingdom30 had 130 nulliparous women blind to the intervention. No double-blind studies were con-
at 41 weeks’ gestation randomized into an acupressure group ducted even though some stated they were double blind.
(n = 70) that received acupressure 20 times intermittently and All of the acupressure studies examined the use of one or
a sham control (n = 60) that received acupressure 20 times 2 points for the reduction of labor pain. This may be adequate
intermittently to the olecranon. No differences were found in to produce a therapeutic effect for this indication. However,
treatment groups with regard to the number of hours until la- for labor induction or augmentation, more than 2 points may
bor in the acupuncture (median, 103 [46] hrs) compared to need to be used at one time. We postulate that an acupunc-
the sham control (median, 72 [38] hrs; P ⬍ .19), need for oxy- ture point prescription may need to be formulated and ad-
tocin, or mode of birth in the acupuncture versus the sham ministered. This is a set of acupuncture points that reflects
control group. and treats a specific patient’s energetic imbalance. Only one
RCT31 on induction of labor with acupuncture stated that the
patients were assessed and treated according to their TCM
Stimulating the Points With Acupressure
pattern diagnosis.
One point may be stimulated singularly or in combination In spite of these limitations, many of the studies that have
with other points during acupressure. When one or multiple been conducted have used large samples and have overall
points are to be stimulated, the first point treated should be the found positive effects for both acupuncture and acupressure.
one most easily accessible. The most effective and safest proto- This suggests that once more rigorous approaches are applied
col has not yet been determined. However, for the reduction to the research process the results will more clearly document
of labor pain, Hamidzadeh29 used 5 pressures per minute to the effectiveness of these modalities.
be administered with each contraction for a period of 20 min- Future acupuncture research on reduction of labor pain
utes to LI4 while in active labor. In clinical practice we have and induction or augmentation of labor should have TCM
observed empirically that firm, deep, constant, and/or circu- practitioners categorize women according to their TCM pat-
lar rotating pressure applied with the thumbs, fingertips, or tern diagnosis and administer the correct point prescriptions.
knuckles to the LI4 and SP6 points for a period of approxi- Each TCM diagnostic pattern group and its corresponding
mately 5 minutes and repeated as needed reduces labor pain. point prescription needs to be studied as a separate entity. In
However, we have not performed any trials that have tested this way laboring women will be best served by TCM research.
this method in a formal study. If possible, the same bilateral Current TCM research in reduction of labor pain and
point should also be stimulated. If both points are not easily induction or augmentation needs to move away from the
accessible, it is acceptable to stimulate one at a time. Points can random phase of experimentation that currently exists.
also be stimulated by being pinched between the thumb and Conducting scientific acupressure and acupuncture studies
index finger. A ballpoint pen cap, a pencil eraser, or a special- that can be double blinded, replicated, and used for specific
ized acupressure tool can also be used. Points should be stimu- indications such as labor pain and augmentation is a crucial
lated based on the tolerance of the woman as well as the person next step. It is essential to establish TCM research protocols to

Journal of Midwifery & Women’s Health r www.jmwh.org 15


allow the forward movement of the TCM research trajectory. acupuncturist; licensed moxibustionalist; and a licensed
Investigators must be able to replicate previous results, add Anma, massage, and Shiatsu therapist.
new knowledge, and advance the science.
Diana J. Wilkie, PhD, RN, FAAN, is Professor, Prairieview
Trust–Earl and Margo Powers Endowed Professor, and Di-
CONCLUSION rector, Academic Center of Excellence in Palliative Care Re-
Research studies to date suggest acupuncture and acupressure search and Education, Department of Biobehavioral Nursing
in labor are beneficial.25,28,29,32 The history, philosophy, and Science, College of Nursing, University of Florida. She is an
scientific mechanisms of TCM have been reviewed along with internationally renowned pain expert.
acupuncture and acupressure techniques and indications.
This review provides insight into these sometimes complex
and difficult to understand practices. The use of acupuncture CONFLICT OF INTEREST
and acupressure for women in labor has potential for treating
The authors have no conflicts of interest to disclose.
many indications and is consistent with the holistic frame-
work of midwifery care. Acupuncture can be administered
only by a licensed acupuncturist, and acupressure can be
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34.Chung U-L, Hung L-C, Kuo S-C, Huang C-L. Effects of LI4 and BL 67 org. A CEU form that can be mailed or faxed is available
acupressure on labor pain and uterine contractions in the first stage of
labor. J Nurs Res. 2003;11(4):251-260.
in the print edition of this issue.

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