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A. Background
Fractures of the pelvis account for less than 5 per cent of all skeletal
injuries, but they are particularly important because of the high incidence of
associated softtissue injuries and the risks of severe blood loss, shock, sepsis
and acute respiratory distress syndrome (ARDS). Like other serious injuries,
they demand a combined approach by experts in various fields. About two-
thirds of all pelvic fractures occur in road accidents involving pedestrians;
over 10 per cent of these patients will have associated visceral injuries
(Solomon et al., 2010).
Pelvic trauma (PT) is one of the most complex management in trauma
care. Patients with pelvic fractures are usually young and they have a high
overall injury severity score (ISS) 25 to 48 ISS. Mortality rates remain high,
probably in excess of 10 per cent, particularly in patients with hemodynamic
instability. For these reasons, a multidisciplinary approach is crucial to
manage the resuscitation, to control the bleeding and to manage bones
injuries particularly in the first hours from trauma. PT patients should have an
integrated management between trauma surgeons, orthopedic surgeons,
interventional radiologists, anesthesiologists, ICU doctors and urologists
(Coccolini et al., 2017).
At present no comprehensive guidelines have been published about
these issues. No correlation has been demonstrated to exist between type of
pelvic ring anatomical lesions and patient physiologic status. Moreover the
management of pelvic trauma has markedly changed throughout the last
decades with a significant improvement in outcomes, due to improvements in
diagnostic and therapeutic tools. In determining the optimal treatment
strategy, the anatomical lesions classification should be supplemented by
hemodynamic status and associated injuries. The anatomical description of
pelvic ring lesions is fundamental in the management algorithm but not
definitive. In fact, in clinical practice the first decisions are based mainly on
the clinical conditions and the associated injuries, and less on the pelvic ring
lesions. Ultimately, the management of trauma requires an assessment of the
anatomical injury and its physiologic effects (Guthrie Hc et al., 2012;
Coccolini et al., 2017).
The major branches of the common iliac arteries arise within the
pelvis between the level of the sacroiliac joint and the greater sciatic notch.
With their accompanying veins they are particularly vulnerable in fractures
through the posterior part of the pelvic ring. The nerves of the lumbar and
sacral plexuses, likewise, are at risk with posterior pelvic injuries. The
bladder lies behind the symphysis pubis. The trigone is held in position by the
lateral ligaments of the bladder and, in the male, by the prostate. The prostate
lies between the bladder and the pelvic floor. It is held laterally by the medial
fibres of the levator ani, whilst anteriorly it is firmly attached to the pubic
bones by the puboprostatic ligament. In the female the trigone is attached also
to the cervix and the anterior vaginal fornix. The urethra is held by both the
pelvic floor muscles and the pubourethral ligament. Consequently in females
the urethra is much more mobile and less prone to injury. In severe pelvic
injuries the membranous urethra is damaged when the prostate is forced
backwards whilst the urethra remains static. When the puboprostatic ligament
is torn, the prostate and base of the bladder can become grossly dislocated
from the membranous urethra. The pelvic colon, with its mesentery, is a
mobile structure and therefore not readily injured. However, the rectum and
anal canal are more firmly tethered to the urogenital structures and the
muscular floor of the pelvis and are therefore vulnerable in pelvic fractures
(Guthrie Hc et al,. 2012; Netter, 2014).
C. Pelvic instability
If the pelvis can withstand weightbearing loads without displacement,
it is stable; this situation exists only if the bony and key ligamentous
structures are intact. An anterior force applied to both halves of the pelvis
forces apart the symphysis pubis. If a diastasis occurs because of capsular
rupture, the extent of separation is checked by the anterior sacroiliac and
sacrospinous ligaments. Should these restraints fail through the application of
a still greater force, the pelvis opens like a book until the posterior iliac spines
abut; because the more vertically oriented long posterior sacroiliac and
sacrotuberous ligaments remain intact, the pelvis will still resist vertical shear
but it is rotationally unstable. If, however, the posterior sacroiliac and
sacrotuberous ligaments are damaged, then the pelvis is not only rotationally
and vertically unstable, but there will also be posterior translation of the
injured half of the pelvis. Vertical instability is therefore ominous as it
suggests complete loss of the major ligamentous support posteriorly. It should
be remembered that some fracture patterns can cause instability which
mimics that of ligamentous disruption; e.g. fractures of both pubic rami may
behave like symphyseal disruptions, and fractures of the iliac wing combined
with ipsilateral pubic rami fractures are unstable to vertical shear (Solomon et
al., 2010).
D. Physiopathology
The lesions at the level of the pelvic ring can create instability of the
ring itself and a consequent increase in the internal volume. This increase in
volume, particular in open book lesions, associated to the soft tissue and
vascular disruption, facilitate the increasing hemorrhage in the retroperitoneal
space by reducing the tamponing effect (pelvic ring can contain up to a few
liters of blood) and can cause an alteration in hemodynamic status (Gosling et
al., 2013).
In the management of severely injured and bleeding patients a
cornerstone is represented by the early evaluation and correction of the
trauma induced coagulopathy. Resuscitation associated to physiologic
impairment and to suddenly activation and deactivation of several
procoagulant and anticoagulant factors contributes to the insurgence of this
frequently deadly condition. The massive transfusion protocol application is
fundamental in managing bleeding patients. As clearly demonstrated by the
literature blood products, coagulation factors and drugs administration has to
be guided by a tailored approach through advanced evaluation of the patient’s
coaugulative asset. Some authors consider a normal hemodynamic status
when the patient does not require fluids or blood to maintain blood pressure,
without signs of hypoperfusion; hemodynamic stability as a counterpart is the
condition in which the patient achieve a constant or an amelioration of blood
pressure after fluids with a blood pressure >90 mmHg and heart rate
<100 bpm; hemodynamic instability is the condition in which the patient has
an admission systolic blood pressure <90 mmHg, or > 90 mmHg but requiring
bolus infusions/transfusions and/or vasopressor drugs and/or admission base
deficit (BD) >6 mmol/l and/or shock index > 1 and/or transfusion requirement
of at least 4–6 Units of packed red blood cells within the first 24 hours
(Paydar et al., 2013).
The Advanced Trauma Life Support (ATLS) definition considers as
“unstable” the patient with: blood pressure < 90 mmHg and heart rate >
120 bpm, with evidence of skin vasoconstriction (cool, clammy, decreased
capillary refill), altered level of consciousness and/or shortness of breath. The
present classification and guideline utilize the ATLS definition. Some authors
suggested that the sacroiliac joint disruption, female gender, duration of
hypotension, an hematocrit of 30% or less, pulse rate of 130 or greater,
displaced obturator ring fracture, a pubic symphysis diastasis can be
considered good predictors of major pelvic bleeding. However unfortunately
the extent of bleeding is not always related with the type of lesions and there
is a poor correlation between the grade of the radiological lesions and the
need for emergent hemostasis (Mutschler et al., 2013).
E. Mechanisms of injuries
Principal mechanisms of injuries that cause a pelvic fracture are due to
a high energy impact as fall from height, sports, road traffic collision
(pedestrian, motorcyclist, motor vehicle, cyclist), person stuck by vehicles.
Ten to fifteen percent of patients with pelvic fractures arrive to the ED in
shock and one third of them will die reaching a mortality rate in the more
recent reports of 32%. The causes of dying are represented in the major part
by uncontrolled bleeding and by patient’s physiologic exhaustion (Cocolini et
al., 2017).
The Young and Burgess classification is recomended for pelvic
fracture which is derived from the initial anteroposterior (AP) radiograph and
is based predominantly on the mechanism of injury and severity of pelvic
fracture.1 Fractures are divided into one of four categories based on the
mechanism of injury, two of which are further subdivided according to the
severity of injury.
1. Anterior posterior compression – secondary to a direct or indirect
force in an AP direction leading to diastasis of the symphysis pubis,
with or without obvious diastasis of the sacroiliac joint or fracture
of the iliac bone.
a. APC I: stable
pubic diastasis <2.5 cm
b. APC II: rotationally unstable, vertically stable
pubic diastasis >2.5 cm
disruption and diastasis of anterior part of sacroiliac joint,
with intact posterior sacroiliac joint ligaments
c. APC III: equates to a complete hemipelvis separation (but
without vertical displacement); unstable
pubic diastasis >2.5 cm
disruption-diastasis of both anterior and posterior
sacroiliac joint ligaments with dislocation
2. Lateral compression – lateral compression force, which cause
rotation of the pelvis inwards, leading to fractures in the sacroiliac
region and pubic rami.
a. LC I: stable
oblique fracture of pubic rami
ipsilateral anterior compression fracture of sacral ala
b. LC II: rotationally unstable, vertically stable
fracture of pubic rami
posterior fracture with dislocation of ipsilateral iliac wing
(crescent fracture)
c. LC III: unstable
ipsilateral lateral compression (LC)
contralateral anteroposterior compression (APC)
3. Vertical shear – an axial shear force with disruption of the iliac or
sacroiliac junction, combined with cephalic displacement of the
fracture component from the main pelvis.
4. Combined mechanism – a combination of two of the above
vectors, which leads to a pattern of pelvic fracture that is a
combination of one or more of the above fracture types (Guthrie
Hc; Owens R; Bircher, 2012).
WSES Classification
The anatomical description of pelvic ring lesions is not definitive in
the management of pelvic injuries. The classification of pelvic trauma into
minor, moderate and severe considers the pelvic ring injuries anatomic
classification (Antero-Posterior Compression APC; Lateral Compression LC;
Vertical Shear VS; CM: Combined Mechanisms) and more importantly, the
hemodynamic status. As already stated the ATLS definition considers as
“unstable” the patient with: blood pressure < 90 mmHg and heart rate >
120 bpm, with evidence of skin vasoconstriction (cool, clammy, decreased
capillary refill), altered level of consciousness and/or shortness of breath
(Cocolini et al., 2017).
The WSES Classification divides Pelvic ring Injuries into three
classes:
1. Minor (WSES grade I) comprising hemodynamically and
mechanically stable lesions
2. Moderate (WSES grade II, III) comprising hemodynamically stable
and mechanically unstable lesions
3. Severe (WSES grade IV) comprising hemodynamically unstable
lesions independently from mechanical status.
F. Management
1. Early Management
Treatment should not await full and detailed diagnosis. It is vital to
keep a sense of priorities and to act on any information that is already
available while moving along to the next diagnostic hurdle. ‘Management’
in this context is a combination of assessment and treatment, following the
ATLS protocols. Six questions must be asked and the answers acted upon
as they emerge:
• Is there a clear airway?
• Are the lungs adequately ventilated?
• Is the patient losing blood?
• Is there an intra-abdominal injury?
• Is there a bladder or urethral injury?
• Is the pelvic fracture stable or unstable?
With any severely injured patient, the first step is to make sure that
the airway is clear and ventilation is unimpaired. Resuscitation must be
started immediately and active bleeding controlled. The patient is rapidly
examined for multiple injuries and, if necessary, painful fractures are
splinted. A single anteroposterior x-ray of the pelvis is obtained. A more
careful examination is then carried out, paying attention to the pelvis, the
abdomen, the perineum and the rectum. The urethral meatus is inspected
for signs of bleeding. The lower limbs are examined for signs of nerve
injury. If the patient’s general condition is stable, further x-rays can then
be obtained. If a urethral tear is suspected, an urethrogram is gently
performed. The findings up to that stage may dictate the need for an
intravenous urogram. By now the examining doctor will have a good idea
of the patients general condition, the extent of the pelvic injury, the
presence or absence of visceral injury and the likelihood of continued
intra-abdominal or retroperitoneal bleeding. Ideally, a team of experts will
be on hand to deal with the individual problems or undertake further
investigations (Skinner HB, 2003; Solomon et al., 2010).
b. External fixation
The volume of the pelvis increases after a mechanically
unstable pelvic fracture. EF has always been the mainstay of
emergency treatment in order to reduce the volume of the pelvis and
control hemorrhage. Two main techniques are available to externally
fix the unstable pelvic ring: external fixator and C-Clamp. While the
external fixator is indicated in type B fractures, the pelvic C-clamp is
used in unstable C type injuries, according to AO/OTA classification.
Placement of a C-Clamp or EPF decreases the pelvic volume by 10%
to 20% and reduces pelvic fractures. Whether this leads to less blood
loss and better outcomes has yet to be shown in the literature. The
standard use of external fixation in the initial treatment algorithms of
patients with unstable pelvic injuries is common and remains a useful
tool in the initial management of these patients. However, because of
their ease of use and fast application, TPBs have largely replaced the
pelvic C-Clamp and EPF for early mechanical stability in pelvic
fracture (Daniel C et al., 2012).
Temporary binders are used to control the hemorrhage from
the pelvic fractures. These devices are very simple and quick to apply,
and they can reduce the pelvic volume. However pelvic binders (PB)
are not external fixator because they do not provide mechanical
stabilization of the pelvis and they must be removed within 24 hours
to avoid pressure sores on the patient. The data confirming efficacy of
pelvic binders in controlling hemorrhage from pelvic fracture remain
unclear because of conflicting studies in the literature. The Consensus
Conference considered EF a pivotal procedure in presence of a
mechanically unstable pelvic fracture and agreed that EF can be
performed both in the shock room in the ED or in the OR, according
to the local facilities. PB is a valid tool, mainly if applied in the
prehospital setting, as a bridge to fixation. It can provide an external
stabilization that could be life saving in patients in extremis. When EF
is not possible (ie orthopedic surgeon is on call during night hours) PB
is a valid alternative, provided EF is accomplished as soon as possible
or the patient transferred to another facility.
i. PB should be applied as soon as pelvic mechanic instability is
assessed, better in the prehospital setting.
ii. Anterior or posterior EF must be accomplished in unstable
fractures as soon as possible in substitution of PB.
iii. EF can be accomplished in the ED or in the OR and appear to
be a quick tool to reduce venous and bony bleeding.
iv. EF, whenever possible, can be the first maneuver to be done in
patients with hemodynamic instability and a mechanically
unstable pelvic fracture (Magnone et al., 2014).
c. Angiography
Angioraphy emerged in the ‘80s as a valid tool to control
arterial bleeding and for many years has been regarded in the vast
majority of trauma centers as the first-line treatment in unstable
patients. On the other hand it has long activation time, as teams are
often on call and they are not present in the hospital on a 24 hours
basis. In the last years improvement of technology allowed for
portable instruments that can lower the threshold for indication
towards this method. Pelvic angiography with embolization seems to
be 85% to 97% effective in controlling bleeding. Some patients will
continue to bleed and require repeat embolization to control
hemorrhage. 4.6% to 24.3% of patients with either no bleeding seen
on the initial angiogram or initially successful pelvic embolization
will require repeat pelvic angiography with repeat embolization
(Magnone et al., 2014).
Which Patients Require Emergent Angiography?
i. Patients with pelvic fractures and hemodynamic instability
or signs of ongoing bleeding after nonpelvic sources of
blood loss have been ruled out should be considered for
pelvic angiography/embolization.
ii. Patients with evidence of arterial intravenous contrast
extravasation (ICE) in the pelvis by CT may require pelvic
angiography and embolization regardless of hemodynamic
status.
iii. Patients with pelvic fractures who have undergone pelvic
angiography with or without embolization, who have signs
of ongoing bleeding after nonpelvic sources of blood loss
have been ruled out, should be considered for repeat pelvic
angiography and possible embolization.
iv. Patients older than 60 years with major pelvic fracture
(open book, butterfly segment, or vertical shear) should be
considered for pelvic angiography without regard for
hemodynamic status.
v. Although fracture pattern or type does not predict arterial
injury or need for angiography, anterior fractures are more
highly associated with anterior vascular injuries, whereas
posterior fractures are more highly associated with posterior
vascular injuries.
vi. Pelvic angiography with bilateral embolization seems to be
safe with few major complications. Gluteal muscle
ischemia/necrosis has been reported in patients with
hemodynamic instability and prolonged immobilization or
primary trauma to the gluteal region as the possible cause,
rather than a direct complication of angioembolization.
vii. Sexual function in males does not seem to be impaired after
bilateral internal iliac arterial embolization (Daniel C et al.,
2012).
4. Fracture Treatment
a. Isolated fractures and minimally displaced fractures
These injuries need only bed rest, possibly combined with
lower limb traction. Within 4–6 weeks the patient is usually
comfortable and may then be allowed up using crutches.
b. Open-book injuries
Provided the anterior gap is less than 2 cm and it is certain that
there are no displaced posterior disruptions, these injuries can usually
be treated satisfactorily by bed rest; a posterior sling or a pelvic binder
helps to close the book. The most efficient way of maintaining
reduction is by external fixation with pins in both iliac blades
connected by an anterior bar; closing the book may also reduce the
amount of bleeding. Placing the pins is made easier if two temporary
pins are first inserted hugging the medial and lateral surfaces of each
iliac blade and then directing the fixing pins between them. Internal
fixation by attaching a plate across the symphysis should be
performed: (a) during the first few days after injury only if the patient
needs a laparotomy; and (b) later on if the gap cannot be closed by
less radical methods.
Fractures of the iliac blade can often be treated with bed rest.
However, if displacement is marked, or if there is an associated
anterior ring fracture or symphysis separation, then open reduction
and internal fixation with plates and screws will need to be considered
(e.g. in displaced LC-II injuries causing a leg length discrepancy
greater than 1.5 cm). It is also possible to reduce and hold some of
these fractures by external fixation.
c. APC-III and VS injuries
These are the most dangerous injuries and the most difficult to
treat. It may be possible to reduce some or all of the vertical
displacement by skeletal traction combined with an external fixator;
even so, the patient needs to remain in bed for at least 10 weeks. This
prolonged recumbency is not without risk. As these injuries represent
loss of both anterior and posterior support, both areas will need to be
stabilized. Two techniques are used: (a) anterior external fixation and
posterior stabilization using screws across the sacroiliac joint, or (b)
plating anteriorly and iliosacral screw fixation posteriorly. Posterior
operations are hazardous (the dangers include massive haemorrhage,
neurological damage and infection) and should be attempted only by
surgeons with considerable experience in this field. Persisting with
skeletal traction and external fixation is probably safer, though the
malposition is likely to leave a legacy of posterior pain. It should be
emphasized that more than 60 per cent of pelvic fractures need no
fixation.
d. Open pelvic fractures
Open fractures are best managed by external fixation. A
diversion colostomy may be necessary (Solomon et al., 2010).
G. Complications
1. Thromboembolism
A careful watch should be kept for signs of deep vein thrombosis or
pulmonary embolism. Prophylactic anticoagulants are advocated in some
hospitals.
2. Sciatic nerve injury
It is essential to test for sciatic nerve function both before and after
treating the pelvic fracture. If the nerve is injured it is usually a
neuropraxia and one can afford to wait several weeks for signs of recovery.
Occasionally, though, nerve exploration is necessary.
3. Urogenital problems
Urethral injuries sometimes result in stricture, incontinence or
impotence and may require further treatment.
4. Persistent sacroiliac pain
Unstable pelvic fractures are often associated with partial or complete
sacroiliac joint disruption, and this can lead to persistent pain at the back
of the pelvis. Occasionally arthrodesis of the sacroiliac joint is needed
(Skinner HB, 2003; Jang et al., 2014).
Daftar Pustaka
Goslings JC, Ponsen KJ, van Delden OM. Injuries to the pelvis and extremities.
In: ACS Surgery: Principles and Practice: Decker Intellectual Properties.
2013.
Jang Y, Shim Hongjin, Pil Young Jung, Seongyup Kim and Keum Seok Bae.
(2016). Preperitoneal pelvic packing in patients with hemodynamic instability
due to severe pelvic fracture: early experience in a Korean trauma center.
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine ; 24
(3)
Jones CB (2012). Posterior pelvic ring injuries: when to perform open reduction
and internal fixation. Instr Course Lect. 2012;61:27–38.
Skinner HB (2003). Current diagnosis & treatment in orthopedics- 3rd ed. New
York: McGraw-Hill Medical Publishers