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Varicose veins are excessively dilated, tortuous superficial leg veins, with resultant pooling of blood. Varicose veins, in addition
to phlebothrombosis and thrombophlebitis, make up at least 90% of significant venous disease (1).
Introduction
In normal veins in the leg, blood that is collected from the capillaries and superficial veins must be directed upwards, against
the pull of gravity, in order to empty into the right atrium via the vena cavae. Apart from the muscular pump mechanism in the
leg, which helps direct venous blood flow upwards, backflow of blood is usually prevented by one way valves. These valves are
crucial components to preventing the development of varicose veins.
Anatomically speaking, blood from superficial veins are drained via perforator veins, which eventually drain into deeper veins
underlying the fascia. Should a valve defect occur, the deep veins can usually withstand the imposed high pressures, caused by
pooling of the blood. However, superficial veins are weaker and are thin-walled. Therefore, they succumb to the high pressures,
which causes them to become dilated and tortuous. Hence, varicose veins form.
6. Family history:
A family history of varicose veins increases the individual's chances of also developing this disease. This is due to the hereditary
nature of acquiring weak venous valves, which contributes to the pathogenesis briefly discussed above.
Clinical Features
Risk Factors
Pregnant women
Old age
Family history
A sedentary lifestyle
Obesity
Prolonged standing
Complications
Phlebitis, caused by chronic inflammation of the vein
Leg ulcers caused by venous insufficiency
Peripheral oedema
Rupture of the varicosity
Dermatitis if it is chronic and severe
Gangrene, in the disease's most severest form
Right heart failure
Differential Diagnosis
Claudication
Superficial thrombophlebitis
Peripheral neuropathy
Cellulitis
Deep vein thrombosis
Investigations
Not all patients will undergo investigation. In some centres diagnosis is made and surgery is performed based on a thorough
patient history as well as a physical examination. However some investigations include:
Colour Duplex ultrasound allowing accurate mapping of veins and venous blood flow in the leg prior to surgery.
Colour-flow imaging, in which doppler sounds are translated into coloured images that allows enhanced vision as well
as interpretation of the affected vein. This method of investigation enables the clinician to accurately see valve
leakages from some varicose veins.
The most common and convenient technique used is by Doppler imaging. A hand held Doppler is used to distinguish
between a vein which has anterograde flow (flow that is in the correct upwards direction) and one that has a valve
defect allowing retrograde flow (flow that is in the incorrect downwards direction). After a patient history and
physical examination, the Doppler test should be used to confirm any suspicions concerning a potential varicose vein
diagnosis.
Management
There are many ways to manage this disease. However, this depends on the severity of symptoms and patient choice:
Conservative
The patient puts up with the discomfort, alleviating the symptoms by resting and facilitating the healing process by elevation of
the affected limb. Exacerbating factors as well as secondary complications, such as obesity, oedema and right heart failure,
must be managed accordingly in order to relieve the patient's symptoms. Ulcers that have formed, as a result of variceal
rupturing, must be kept clean to avoid infection and aid the healing process.
Medical
Injection of a sclerosing substance (hypertonic saline or sodium tetradecyl sulfate) into the varicosities causing endothelial
damage, sclerosis and degradation of the vein. This solution degrades the endothelium of the vein, which causes the
varicosed vein to swell. The vein then undergoes fibrosis and may eventually fade from view. This is only effective in mild cases.
Sclerotherapy is done while the patient is standing – an elastic band is wrapped around the legs after the procedure. These
injections do not work as effectively as surgery and have many side effects.
Surgical
Vein-Stripping
The surgeon makes a cut at the bottom (ankle end) and the top (groin end) of the varicose vein. A thin, plastic tube-like
instrument is placed into the vein and tied around it. When the tube is pulled out, it pulls the vein from out under the skin.
Small surgical cuts can also be made over individual veins to remove them. Bandages and stockings are worn
afterwards. Occassionally, additional injections may be needed to get rid of any residual veins not dealt with by surgery.
Avulsion
Surgical incisons or cuts are made over various regions of the leg where the varicose veins are. Then, forceps are used to extract
the vein out of the leg.
Prognosis
If left untreated, varicose veins become even more dilated and tortuous. Eventually, the veins become lacerated and
haemorrhagic. Even worse, gangrene may ensue, which would require amputation of the affected limb. Even though success
rates are very high with surgical treatment, a ten year recurrence rate of 70% has been reported (2). An explanation as to
why varicose veins can recur is due to the fact that venous branches can re-grow. These new branches can penetrate the scar
tissue, as a result of the surgery, to connect with healthy superficial veins.