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HEADACHE Toolbox
Non-Steroidal
Anti-Inflammatory
Drugs (NSAIDs) for
Acute Migraine
Treatment head_1785 1635..1636
1635
1636
Virtually all of the NSAIDs may irritate the effective than administration of either drug
lining of the stomach or intestine, and this can alone, and there is currently available a
be a particular problem—and even a compound oral medication, Treximet, that
contraindication to NSAID use—for individuals combines an NSAID (naproxen sodium) and a
with peptic ulcer disease, gastroesophageal triptan (sumatriptan).
reflux (GERD), irritable bowel syndrome, or
Treatment Hint: During an acute migraine
other gastrointestinal disorders. “Heartburn”
attack the stomach may not move an orally
and diarrhea are common side effects of the
administered NSAID along to the small
NSAIDs, and fluid retention also may occur
intestine, where the NSAID normally would be
(albeit infrequently with sporadic, “as needed”
absorbed; co-administration of a caffeinated
usage). In rare instances the NSAIDs may
beverage with the NSAID may overcome this
impair the kidneys or liver, but this is much
problem and promote more effective intestinal
more likely to occur in individuals who
absorption and a higher likelihood of a positive
administer an NSAID on a daily or near-daily
treatment response.
basis.