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Nerve
DR SUGIANTO SPS MKES PHD
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CRANIAL NERVES
INFRATENTORIAL
BRAINSTEM
◦ Midbrain : CN III, IV
◦ Pons: CN V, VI, VII, VIII
◦ Medulla: CN IX, X, XI, XI
◦ Outside the Brainstem : CN I, II
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Cranial nerves
Cranial nerve
Brain stem
Mid brain III.& IV. - fr.MBr.
Crus cerebri
Pons V.,VI, VII. - Pons
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Brainstem Components
Front
Rear
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VENTRAL ASPECT
CN III
Basis Pedunculi
CN IV
Posterior perforated
substance
CN V
pons CN VI
CN VII, VIII
Hypoglossal N
Inferior olive M
Glossopharyngeal N
pyramid
Vagus N
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DORSAL ASPECT
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Brainstem Divisions
Midbrain
Pons
Medulla Oblongata
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TrueCranial nerves originate from
Brainstem Brain ( ) median sagittal section
Brain stem(FR.B/L. U/W.) Includes;
Medulla
Pons
Mid brain
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Brain viewed fr. below
Crainal nerves fr. Br.stem
III.,VI.& XII
In a vertical line occupy more medial
as they come out of the Br.stem
III N.
fr.medial side of crus cerebri
of m.brain
VI N.
- junction b/t Pons & Pyramid of Medulla
XII N. Pyramid
Olive
-b/t. Pyramid & Olive
iv N.
- from M.brain
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Anterior
Cranial N. fr. Br.Stem
cont…
VII , VIII.N.
-at the Cerebellopontine angle
-b/t Pons & Olive
Olive
Pyramid
IX, X, XI.(cr.roots)
-b/t Olive & Inf.Cerebellar pedun.
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Brain stem (front view)
viii. vii.
ix.Glosopharyngeal
Medulla
x. Vagus
xi.Accessory
xii.
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Functional Component carried by The Cranial
Nerves
General Somatic Afferent (GSA)
◦ These fibre carry general sensation ( touch, presure, pain, and temperature)
◦ From cutaneus structure and mucous membrane of the head, and general
proprioception (GP) from somatic structure such as muscle, tendons, and joint of the
head and neck
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Functional Component carried by The Cranial
Nerves
Special Somatic Afferent (SSA)
◦ These fibre carry special sensory input from the eye (retina), for vision, and from the
ear (vestibular apparatus for equilibrium, and the cochlea for hearing)
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Modality Cranial Nerve
General somatic afferent (GSA) V, VII, IX,X
General somatic efferent (GSE) III, IV, VI
General visceral afferent (GVA) VII, IX, X
General visceral efferent (GVE) III, VII, IX, X
Special somatic afferent (SSA) II, VII
Special visceral afferent ( SVA ) VII, IX, X
Special visceral efferent ( SVE ) V, VII, IX, X
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The Cranial Nerves
I. Accessory nerve
II. Olfactory nerve
III. Optic nerve
IV. Oculomotor nerve
V. Trochlear nerve
VI. Trigeminal nerve
VII. Abducens nerve
VIII. Facial nerve
IX. Vestibulocochlear nerve
X. Glossopharyngeal nerve
XI. Vagus nerve
XII. Hypoglossal nerve
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Cranial nerves carrying Motor
only
Extra ocular muscles
III. Oculomotor
(voluntary/striated muscle)
IV. Trochlear
derived from Somites
VI. Abducent
XII. Hypoglossal- muscles of Tongue derived from Somites
XI. Accessory - muscles derived from Branchial arch
Cranial nerves carrying both
Motor & Sensory (Mixed nerves)
V.Trigeminal
VII.Facial
IX.Glossopharyhgeal
X.Vagus
OLFACTORY NERVE
ONLY sensory nerve that has no precortical relay in the thalamus
ANATOMICAL PATHWAY
◦ First –order neurons : olfactory receptor cells, that project to the mitral cells of the olfactory
bulb
◦ Mitral cells project to the lateral olfactory stria via the olfactory tract, to the primary olfactory
cortex, and to the amygdala.
◦ Primary olfactory cortex ( Area 34): Pyriform cortex
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OLFACTORY NERVE
CLINICAL CORRELATION
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Olfactory Nerve (= CN or N I)
1º function?
Origin?
Destination? _____________(By way of cribiform plate of
ethmoid)
Only CN directly attached to Cerebrum
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OLFACTORY NERVE
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OPTIC NERVE
FUNCTIONS: Subserves vision and pupillary light reflex ( afferent limb )
Visual acuity
Visual field
Funduscopic examination
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OPTIC NERVE
VISUAL PATHWAY
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OPTIC NERVE
VISUAL FIELD
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Cranial Nerves 2 and 3
Pupillary size
Pupillary light reflex
◦ Direct and consensual
Accomodation
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Cranial Nerve 2
Visual acuity
◦ Hold VA chart 4 inches
from patients face
◦ Test and occlude each eye
alternately
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Cranial Nerve 2
Visual field testing
◦ Confrontation test
◦ Stay 1 foot from the patient
◦ Cover one eye
◦ Keep uncovered eye locked
On yours
◦ Slowly bring in your hand
from the periphery until
patient sees it
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Cranial Nerve 2
Using an
ophthalmoscope, observe
the
◦ optic disc
◦ physiological cup
◦ retinal vessels
◦ fovea.
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OCULOMOTOR NERVE
FUNCTION: Moves the eye, constricts the pupil, accomodates and
converges
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OCULOMOTOR NERVE
Innervates the following
◦ Medial rectus muscle ( adducts )
◦ Superior rectus muscle
(elevates, intorts, adducts )
◦ Inferior rectus muscle
(depresses, extorts, adducts )
◦ Inferior oblique ( elevates, extorts, abducts )
◦ Levator papalebrae muscle
(elevates the upper lid)
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Human Anatomy, Frolich, Head/Neck IV: Cranial Nerves FK UKDW 37
CLINICAL
CONSIDERATIONS
Unilateral damage to the oculomotor nerve results in deficits in the
ipsilateral eye.
The following ipsilateral muscles will be paralyzed: the levator palpebrae
superioris, resulting in ptosis (G., “drooping”) of the upper eyelid; the
superior and inferior recti, resulting in an inability to move the eye
vertically; and the medial rectus, resulting in an inability to move the eye
medially.
The eye deviates laterally (due to the unopposed lateral rectus), resulting
in lateral strabismus.
The sphincter pupillae muscle becomes nonfunctional due to interruption
of its parasympathetic innervation. The pupil ipsilateral to the lesion will
remain dilated (mydriasis) and does not respond (constrict) to a flash of
light.
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OCULOMOTOR NERVE
CLINICAL CORRELATION
◦ Oculomotor palsy (ANISOCORIA) in cases of transtentorial
/ uncal herniation
◦ Oculomotor palsy results in diplopia, internal
ophthalmoplegia
◦ Aneurysm of the carotid or the posterior communicating
arteries frequently compress CN III within the cavernous
sinus or the intepeduncular cistern
◦ Diabetic oculomotor palsy damaging the central fibers
and sparing the pupilloconstrictor fibers.
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8. What extraocular muscle is affected in this patient?
What innervates this muscle?
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TROCHLEAR NERVE
Pure Motor Nerve
Innervates the superior oblique muscle, which
depresses, intorts and abducts the eye
ANATOMICAL PATHWAY
◦ Arises from the caudal midbrain,
◦ decussates beneath the superior medullary velum of the midbrain,
◦ exits dorsally, caudal to the superior colliculus
◦ encircle the midbrain within the subarachnoid space
◦ Passes thru the cavernous sinus
◦ Enters the orbit via the superior orbital fissure
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TROCHLEAR NERVE
CLINICAL CORRELATION
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TRIGEMINAL NERVE
Has 3 divisions : ophthalmic, maxillary,
mandibular
Innervates
◦ Muscles of mastication
◦ Temporalis, masseter, lateral and medial pterygoids
◦ Tensor tympani
◦ Veli palatini
◦ Myelohyoid muscle
◦ Anterior belly of the digastric muscle
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TRIGEMINAL NERVE
Provides sensory innervation to the face, mucous membranes of the
nasal and oral cavities and frontal sinus, hard palate, and deep
structures of the head.
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V. Trigeminal nerve
Distributions
Motor (Branchiomotor)
i.Muscles of (1st.pharyngeal arch)
muscles of mastication,
ant.belly of digastric, mylohyoid & tensors palati & tympani
Sensory
i. from Skin of face and scalp( in front of chin-ear vertex line)
ii. from nasal mucosa,paranasal sinus & eye (V.i )
nasal mucosa, max.sinus, palate,upperjaw &teeth (V.ii.)
oral mucosa, ant.2/3 of tongue, lower jaw &teeth (V.iii.)
iii. Dura mater of cranial cavity
V: Trigeminal (3 nerves in 1!)
V1. Ophthalmic
◦ Exits with eye muscle group (superior orbital fissure, through orbit to superior
orbital notch/foramina)
◦ Sensory to forehead, nasal cavity
V2. Maxillary
◦ Exits foramen rotundum through wall of maxillary sinus to inferior orbital
foramina)
◦ Sensory to cheek, upper lip, teeth, nasal cavity
V3. Mandibular
◦ Exits foramen ovale to mandibular foramen to mental foramen
◦ Motor to jaw muscles--Masseter, temporalis, pterygoids, digastric
◦ Sensory to chin
◦ Sensory to tongue
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TRIGEMINAL NERVE
CLINCIAL CORRELATION
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Trigeminal neuralgia
A common clinical concern regarding the trigeminal nerve is trigeminal
neuralgia.
This condition results from idiopathic etiology (unknown cause) and is
manifested as intense, sudden onset, and recurrent unilateral pain in
the distribution of one of the three divisions of the trigeminal nerve,
most commonly the maxillary division
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Cranial Nerve 5
Facial Sensation
◦ Ophthalmic
◦ Maxillary
◦ Mandibular
Corneal Reflex
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Cranial Nerve 5
Masseter tone
Open mouth against
resistance applied at the
base of the chin
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ABDUCENS NERVE
PURE MOTOR NERVE
Innervates the lateral rectus muscle
ANATOMICAL PATHWAY
◦ Arises in the tegmentum of caudal pons
◦ Exits and pass through the corticospinal tract
◦ Passes through the pontine cistern and cavernous sinus
◦ Enters the orbit via the superior orbital fissure
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Abducens
(CN VI)
Human Anatomy, Frolich, Head/Neck IV: Cranial Nerves FK UKDW 55
ABDUCENS NERVE
CLINICAL CORRELATION
◦ Most common isolated palsy resulting from the long peripheral course of the
nerve..
◦ Convergent (medial) strabismus (esotropia) with inability to abduct the eye
◦ Horizontal diplopia
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Right gaze with impaired abduction of right eye.
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FACIAL NERVE
Mediates facial movement, taste, salivation, lacrimation and general
sensation from external ear
Innervates the taste buds from the anterior two-thirds of the tongue
Innervates the lacrimal, submandibular and sublingual glands.
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VII: Facial Nerve
(exits cranial cavity with VIII--internal auditory meatus)
Facial muscles (five branches fan out over face from stylomastoid
foramen)
◦ Temporal
◦ Zygomatic
◦ Buccal
◦ Mandibular
◦ Cervical
Lacrimal glands
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Human Anatomy, Frolich, Head/Neck IV: Cranial Nerves FK UKDW 63
FACIAL NERVE
ANATOMICAL PATHWAY
◦ Geniculate ganglion in the temporal bone
◦ Exits the brainstem in the cerebello pontine angle
◦ Enters the internal auditory meatus and the facial canal
◦ Exits the skull via the stylomastoid foramen
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FACIAL NERVE
CLINICAL CORRELATION
◦ Central Facial Palsy
◦ Bell’s palsy ( peripheral facial palsy )
◦ Loss of corneal reflex (efferent limb)
◦ Loss of taste from the anterior 2/3 of the tongue
◦ Bilateral facial palsy seen in GBS
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Cranial Nerve 7
Inspect the face for any
facial asymmetry
◦ drooping, sagging or
smoothing of normal
facial creases
Raise eyebrows
Close eyes
Smile
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9a. Is this a peripheral or central facial nerve palsy?
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FACIAL NERVE
Central or Peripheral
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9b. Is this a peripheral or central facial nerve palsy?
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VESTIBULO- COCHLEAR NERVE
VESTIBULAR NERVE
◦ Maintains equilibrium
COCHLEAR NERVE
◦ Mediates hearing
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Vestibulocochlear (N VIII)
VESTIBULO- COCHLEAR NERVE
VESTIBULAR NERVE
◦ Associated with the cerebellum, flocullo nodular lobe
◦ Regulates compensatory eye movements
◦ ANATOMICAL PATHWAY
◦ Bipolar neurons in the vestibular ganglion
◦ Projects to the hair cells of the cristae of the semicircular ducts of the
utricle and saccule
◦ Project to the 4 vestibular nuclei of the brainstem and to the
flocculonodular lobe of the cerebellum
◦ Conducts efferent fibers to the hair cells from the brainstem
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VESTIBULO- COCHLEAR NERVE
VESTIBULAR NERVE
◦ CLINICAL CORRELATION
◦ Lesions result in
◦ dysequilibrium
◦ vertigo
◦ nystagmus
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VESTIBULO- COCHLEAR NERVE
COCHLEAR NERVE
◦ ANATOMICAL PATHWAY
◦ Spiral ganglion of the cochlea
◦ Projects its peripheral processes to the hair cells of Organ of Corti
◦ Project its central processes to the dorsal and ventral cohclear nuclei of the brainstem
◦ Conducts efferent fibers to the hair cells from the brainstem
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VESTIBULO- COCHLEAR NERVE
COCHLEAR NERVE
◦ CLINICAL CORRELATION
◦ Lesions result in
◦ Hearing loss (sensorineural deafness )
◦ Tinnitus
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Cranial Nerve 8
Gross hearing test
Weber test
◦ Test for lateralization
◦ Normal – sound is heard in both
ears
◦ Abnormal – sound lateralizes to
the abnormal ear
Rinne test
◦ To differentiate conductive from
sensorineural hearing loss
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Pemeriksaan weber
Garputala di letakan di dahi penderita
Pada keadaan normal kiri dan kanan sama keras
Bila terdapat tuli konduksi di sebelah kiri, misal oleh karena otitis
media, pada tes weber terdengar kiri lebih keras.
Bila terdapat tuli persepsi di sebelah kiri, maka tes weber terdengar
lebih keras di kanan
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Pemeriksaan Rinne
Pada telinga sehat, pendengaran melaui udara di dengar lebih lama dari
pada tulang
Garputala ditempatkan pada planum mastoid sampai penderita tidak
dapat mendengarnya lagi, kemudian garputala dipindahkan ke depan
meatus eksternal. Jika pada posisi yg kedua ini masih terdengar di
katakan tes positif,
PADA ORANG NORMAL ATAU TULI PERSEPSI, TES RINNE POSITIF, PADA
TULI KONDUKTIF TES RINNE NEGATIF
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Pemeriksaan Rinne
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GLOSSOPHARYNGEAL NERVE
SENSORY NERVE
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GLOSSOPHARYNGEAL NERVE
Innervates the external ear and external auditory
meatus
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Human Anatomy, Frolich, Head/Neck IV: Cranial Nerves FK UKDW 83
GLOSSOPHARYNGEAL NERVE
ANATOMICAL PATHWAY
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GLOSSOPHARYNGEAL NERVE
CLINCIAL CORRELATION
◦ Glossopharyngel Neuralgia
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If CN 9 on the right is not
functioning (e.g. in the setting of a
stroke), the uvula will be pulled to
the left. The opposite occurs in the
setting of left CN 9 dysfunction.
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VAGUS NERVE
Mediates phonation, swallowing, elevation of the
palate, taste and cutaneous sensation from the ear.
ANATOMICAL PATHWAY
◦ Exits the brainstem from the postolivary sulcus
◦ Exits the skull via jugular foramen with CN IX, and CN XI
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Human Anatomy, Frolich, Head/Neck IV: Cranial Nerves FK UKDW 88
VAGUS NERVE
Innervates the pharyngeal arch muscles of the
larynx and pharynx, striated muscle of the upper
esophagus, muscle of the uvula, and the levator
veli palatini and palatoglosus muscles
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VAGUS NERVE
CLINCIAL CORRELATION
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CLINICAL
CONSIDERATIONS
Unilateral damage of the vagus nerve near its emergence from the
brainstem results in a number of deficiencies on the ipsilateral side.
Damage to the SVE branchiomotor fibers will cause flaccid paralysis or
weakness of: (i) the pharyngeal muscles and levator veli palatini of the
soft palate, resulting in dysphagia (difficulty swallowing); (ii) the
laryngeal muscles, resulting in dysphonia (hoarseness) and dyspnea
(difficulty breathing); and (iii) loss of the gag reflex (efferent limb).
Damage to the GVA fibers will cause loss of general sensation from the
soft palate, pharynx, larynx, esophagus, and trachea. Damage to the
GVE fibers will cause cardiac arrhythmias.
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SPINAL ACCESSORY
NERVE
Mediates head and shoulder movement and innervates
laryngeal muscles
◦ CRANIAL DIVISION
◦ Arises from the nucleus ambiguus of the medulla
◦ Exits the medulla and join CN X
◦ Innervates the intrinsic muscles of the larynx via the inferior (recurrent) laryngeal
nerve with the exception of the cricothyroid muscle
◦ SPINAL DIVISION
◦ Arises from the ventral horn of cervical segments C1 to C6
◦ Innervates the sternocleidomastoid muscle with the cervical plexus (C2) nd the
trapezius muscle (C3,C4)
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SPINAL ACCESSORY
NERVE
CLINICAL CORRELATION
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Cranial Nerve 11
Look for wasting of the
trapezius muscles
Ask the patient to shrug
their shoulders against
resistance
Ask the patient to turn
their head to the side
against resistance
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Place your open left hand against
the patient's right cheek and ask
them to turn into your hand while
you provide resistance. Then
repeat on the other side. The right
Sternocleidomasoid muscle (and
thus right CN 11) causes the head
to turn to the left, and vice versa.
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HYPOGLOSSAL NERVE
Mediates tongue movement
ANATOMICAL PATHWAY
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HYPOGLOSSAL NERVE
CLINICAL CORRELATION
◦ Protrusion cause the tongue to point toward the weak side because of
the unopposed action of the opposite genioglossus muscle
A lesion in the hypoglossal nucleus or nerve results in flaccid paralysis and subsequent
atrophy of the ipsilateral tongue musculature.
Hemiparalysis of the tongue causes creasing (wrinkling) of the dorsal surface of the
tongue ipsilateral to the lesion
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Cranial Nerve 12
Ask the patient to
protrude tongue
Watch for deviation
◦ Deviates toward the same
side in a peripheral lesion
◦ Deviates toward the
opposite side in a central
lesion
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Organization of Nervous System
Central Nervous System (CNS) = brain and spinal cord
CNS PNS
Peripheral Nervous System
skin
muscle
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Spinal Cord
Segments
Pg 393
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Gross Anatomy of the Spinal Cord
C1
C2
Cervical spinal C3
nerves C4
C5
C6 Cervical
C7 enlargement
C8
T1
T2
T3
T4
T5
T6
T7
Thoracic T8
spinal Posterior
nerves T9 median sulcus
T10
T11 Lumbosacral
enlargement
T12
Conus
L1 medullaris
L2
Lumbar Inferior
spinal L3 tip of
nerves spinal cord
L4
Cauda equina
L5
S1
Sacral spinal
S2
nerves
S3
S4
S5
Accessory
nerve (N XI)
Cranial
Hypoglossal
nerves
nerve (N XII)
Great auricular nerve
Lesser occipital
nerve
C1
C2
Omohyoid muscle
Supraclavicular Phrenic nerve
nerves
Clavicle Sternohyoid muscle
Sternothyroid muscle
T12
L1
L5
Lumbosacral trunk
S1
SACRAL
Superior gluteal nerve PLEXUS
S2
Inferior gluteal nerve
S3
S4
Sciatic nerve S5
Iliohypogastric nerve
Ilioinguinal nerve
Genitofemoral nerve
Lateral femoral
cutaneous nerve
Femoral nerve
Superior gluteal nerve
Inferior gluteal nerve
Pudendal nerve
Posterior femoral
cutaneous nerve (cut) Obturator nerve
Sciatic nerve
Saphenous
nerve
Sural
Saphenous nerve nerve
Fibular
nerve
Common fibular
nerve
Saphenous Sural
nerve nerve
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Types of Nerve Fibers
Sensory = Afferent Nerve fibers = picked up by sensory receptors
throughout body (PNS) and carried TOWARDS spinal cord + brain (CNS)
Motor = Efferent Nerve fibers = carried AWAY from CNS by nerves of
PNS to innervate body’s muscles and glands
Remember: SAME
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OCULOMOTOR NERVE
Visceral efferent consists of the pre-ganglionic parasympathetic fibers
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