a new life. well planned.

non-invasive
prenatal test
Provide the best clarity and reassurance
to your patients.
Claria
From MedGenome

MedGenome is driven to enable clinicians to deliver the bes t outcomes to

their pa tients. Our pa ssion to deliver actionable insights to clinicians has
resulted in the development of Claria - a suite of NGS (Next-Generation
Sequencing) technology-bas ed solutions for reproductive t esting.

Claria offers the most accurate Non-Invasive Prenatal Screening Tes t (NIPT ),
the Genetic Carrier Screening Test and the Preimplantation Genetic
Screening/Diagnosis (PGS/PGD).

Additionally, Claria offers an absolutely free, on-demand pre and post- test
genetic counselling to all your pa tients.

Non-Invasive
Prenatal Screening
test

Preimplantation Carrier Screening

Genetic Screening Test
Claria NIPT
MedGenome Claria NIPT is a simple, safe and non-invasive prenatal screening test that
provides assurance to expectant parents with accurate genetic information about their baby.
This screening test can be performed from as early as the 9th week of a pregnancy. Compared
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higher sensitivity and lower false positive rate for the conditions screened.

Claria NIPT now screens for microdeletions

Claria NIPT now covers clinically relevant microdeletions that occur in 1-1.7% of all
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deletion exceeds the risk for Down syndrome. These sub-chromosomal abnormalities
which collectively have a population incidence of approximately 1 in 1000 will result in
severe physical and /or intellectual impairments.

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risk for Down syndrome

Chromosomal abnormalities in India

High prevalence of chromosomal abnormalities: 1 in 200 births
Over 25 million births every year in India
Over 130,000 births with chromosomal abnormalities in India
every year
Incidence of Down Syndrome is 1 in 850 live births in India
1 in 1000 is the population incidence for microdeletions, the
disorders included are 22q11.2 deletion syndrome, 1p36 deletion
syndrome, Cri du chat syndrome, Prader-Willi syndrome,
Angel man syndrome*

A womans risk of having a term pregnancy with certain chromosomal abnormalities

increases with age.

* Combined prevalence using higher end of published ranges from Gross et al. Prenatal Diagnosis
2011; 39, 259-266; and www.genetests.org. Total prevalence may range from 1/1071 - 1/2206.
The risk of having a baby with Down Syndrome*
For a 26 yr old woman: 1 in 1300
The risk factor increases by almost 5x
For a 36 yr old woman: 1 in 270

However, the incidence of microdeletions is independent of maternal age.

Incidence of microdeletions at birth

1/250

1/500

1/1000

1/2000
20 22 24 26 28 30 32 34

Maternal Age

Down Syndrome1 Panorama Microdeletions Panel 2

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syndrome live births. Prenat Diagn. 2003 Mar;23(3):252-8.
1 Snijders, et al. Ultrasound Obstet Gynecol 1999; 13: 167-170.
2 Combined prevalence using higher end of published ranges from Gross et al. Prenatal Diagnosis
2011; 39, 259-266; and www.genetests.org. Total prevalence may range from 1/1071 - 1/2206.
What are the chromosomal and structural
anomalies detected by Claria NIPT?
Common aneuploidies T21, T18, T13, Sex Chromosomes abnormalities, triploidy and
5 common microdeletion syndromes from fetal DNA obtained from maternal blood.

Aneuploidy Microdeletions
Trisomy 21 (Down Syndrome) 22q11.2 Deletion Syndrome
Trisomy 18 (Edwards Syndrome) 1p36 Deletion Syndrome
Trisomy 13 (Patau syndrome) Prader-Willi Syndrome
Triploidy Angelman Syndrome
Monosomy X (Turner Syndrome) Cri-du-chat Syndrome
Klinefelter Syndrome, Triple X
Syndrome, Jacobs Syndrome

Unlike other tests, Claria NIPT also tests for triploidy and vanishing twin. It is the only test
that differentiates between maternal and fetal DNA, which helps avoid false positives.

Claria NIPT does not test for the gender of the foetus.
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Why screening is important

Reassurance for expecting parents
Early information for better management
Preparation for the birth and early
intervention wherever possible
Why Claria NIPT?

Over 99.9% accuracy

Can be screened from as early as the 9th week

of a pregnancy.

A simple, and safe blood draw from mothers arm,

posing no risk to the foetus

The only SNP technology based NIPT in India

Reports foetal fraction in each case

FREE Pre & Post test genetic counseling for all patients

The only lab to process NIPT samples in India, enabling for

accurate and faster reporting.
Who is Claria NIPT for?
All pregnant women who need insight into their babys development can avail the test,
regardless of their age. Claria NIPT is recommended for all pregnancies.

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nancies, irrespective of the risk. For physicians, it is important to recommend
this test for pregnancies where:

The woman is above 30 years of age

An abnormal ultrasound report
Couples with a family history of chromosomal conditions
or birth defects
Couples who have had a child with a chromosomal disorder
Couples with a history of infertility or pregnancy loss
(miscarriages or stillbirths)
Traditional screening
test vs. Claria NIPT

Traditional screening test Claria NIPT

Test accuracy: 75-90% Test accuracy: >99.9%

False positives: 5% False positives: <0.1%

Affected, undetected Affected, undetected

cases: 10-15% cases: <0.1%

Can only be done from the

Can be done from as
11th week onwards and
early as the 9th week
within certain gestational
of pregnancy
time frames
Claria NIPT in 5 simple steps

1. Ask about Claria NIPT

To book the test, dial 1800 -1037590 or visit www.medgenomeclaria.com and we will
help you locate the sample collection centre closest to your patient.

2. Quick and simple blood draw

A small sample of blood is drawn from the mothers arm. This is a non-invasive proce-
dure and poses no risk to the baby.

3. Receive highly accurate reports

Medgenome is the only lab enabled to process NIPT samples in India. This ability allows
for high accuracy and faster reporting.3. Receive highly accurate reports

4. Review the test results

Our Genetic Counsellor and Scientists will help you understand the detailed report and guide you accordingly.

5. Get in touch with us for counselling

<RXUSDWLHQWVFDQFDOORXUWROOIUHHQXPEHUDQG[DQDSSRLQWPHQWWRJHWDIUHHFRXQVHOOLQJ
session with one of our genetic counselling experts.
The Claria NIPT advantage for your patients
The CLARIA NIPT ADVANTAGE for your patients:
Over 99.9% accuracy
Can be screened from as early as 9th week of a pregnancy
A simple, and safe blood draw from mothers arm, posing
no risk to the foetus
The only SNP technology based NIPT in India
Reports foetal fraction in each case
FREE Pre & Post test genetic counseling for all patients
The only lab to process NIPT samples in India, enabling for
accurate and faster reportingv

Order now
MedGenome Labs Pvt. Ltd.
3rd Floor, Narayana Netralaya Building,
Narayana Health City, #258/A,
Bommasandra, Hosur Road,
Bangalore 560099

Toll free no: 1800-1037590 | SMS CLARIA to 56767

www.medgenomeclaria.com | doctorsupport@medgenomeclaria.com