Adesh University

Center for interdisciplinary biomedical research

Title: Neurogenic Inflammation

Presenter: Dr.Imtiyaz Nadaf

Abstract:

The CNS is endowed with an elaborated response repertoire termed neuroinflammation,

which enables it to cope with pathogens, toxins, traumata and degeneration. On the basis of
recent publications, we deduce that orchestrated actions of immune cells, vascular cells and
neurons that constitute neuroinflammation are not only provoked by pathological
conditions but can also be induced by increased neuronal activity. We suggest that the
technical term neurogenic neuroinflammation should be used for inflammatory reactions
in the CNS in response to neuronal activity. We believe that neurogenic neuroinflammation
maintains homeostasis to enable the CNS to cope with enhanced metabolic demands and
increases the computational power and plasticity of CNS neuronal networks. However,
neurogenic neuroinflammation may also become maladaptive and aggravate the outcomes
of pain, stress and epilepsy.

Keywords: Diseases of nervous system, Neuroimmunology, neuoropathic pain

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