BA LPCplus 2012-10 1-0 en

Operating Manual
SCADA Software
LPCplus
for use with freeze-dryers with CHRIST LSCplus controller
wae
2012-10
Translation of the original German language instructions Rev. 1.0
LPCplus;for use with freeze-dryers with CHRIST LSCplus controller
SCADA Softw
ware LPCpluss
Copyrigh
ht by
Martin Chriist Gefriertro
ocknungsan
nlagen GmbbH
An der Untteren Sse 50
37520 Osteerode am Harz
H
Tel.: 9 (0) 5522 / 5007-0

+49
Fax: 9 (0) 5522 / 5007-12
+49
http://www..martinchris
st.de
info@martiinchrist.de
2012-10
0
2
Translati on of the orig
ginal German
n language in
nstructions Rev.
R 1.0 wae
e
SCADA Softw
ware LPCpluss
Table of
o Contents
s
1 Gene
eral inform
mation.......................... ........................................................................................5 5
1.1 Inntroduction .................................... ....................................................................................... 5
5
1.2 CConformity with
w 21 CFR R Part 11 .... ....................................................................................... 6 6
2 Systtem control and proce ess monito oring ................................................................................7 7
2.1 Fundamenta al principles ................. ....................................................................................... 7 7
2.1.1 LPCplus screen
s ........................ ....................................................................................... 7
7
2.1.2 User log
g-in and pro ocess record ding .............................................................................. 11
2.1.3 Visualisaation, alarm ms, and systtem informa ation ........................................................... 15 5
2.1.4 Processs Graphics ................... ..................................................................................... 19 9
2.1.5 Processs events ....................... ..................................................................................... 26 6
2.1.6 Processs control ....................... ..................................................................................... 29 9
2.2 M Manual freezze-drying ..................... ..................................................................................... 39 9
2.3 P Program/recipe-controlled freeze-d drying ............................................................................ 41
2.3.1 Creatingg/modifying a freeze-drrying progra am/recipe ................................................... 41
2.3.2 Freeze-ddrying phas ses in detaill .................................................................................... 59 9
2.3.22.1 Preco ooling ........................... ..................................................................................... 59 9
2.3.22.2 Freezzing .............................. ..................................................................................... 60 0
2.3.22.3 Main drying
d (sublimation) .... ..................................................................................... 62 2
2.3.22.4 Secon ndary drying g (desorptio on) ................................................................................. 67 7
2.3.3 Executinng a freeze--drying prog gram/recipe e ................................................................. 68 8
2.4 A Aeration ......................................... ..................................................................................... 733
2.5 D Defrosting ...................................... ..................................................................................... 75 5
2.6 P Performing a leak test.................... ..................................................................................... 77 7
2.7 M Media drain .................................... ..................................................................................... 79 9
3 Admministrationn functions of the softtware.............................................................................81
3.1 U User adminisstration ........................ ..................................................................................... 81
3.1.1 Safety settings
s ........................ ..................................................................................... 81
3.1.2 Creating g/editing a user u accoun nt ................................................................................... 833
3.1.3 Definingg the user le evels .......... ..................................................................................... 85 5
3.2 D Documentatiion .............................. ..................................................................................... 87 7
3.3 D Data backup p .................................. ..................................................................................... 977
3.4 Extras ............................................ ..................................................................................... 99
9
3.5 V Vapour presssure curve for ice ....... ................................................................................... 105 5
4 Index ................................................... ....................................................................................107
7
2012-10
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Translation of the origina
al German lan
nguage instru
uctions Rev.. 1.0 wae
SCADA Softw
ware LPCpluss
1 General informatio
on
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2012-10
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Translation of the orig
ginal German
n language in
nstructions Rev.
R 1.0 wae
e
SCADA Softw
ware LPCpluss
1.1 Introduction
n
1 Gen
neral in
nformatiion
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1.1 In
ntroductiion
The CHR RIST LPCpluss SCADA so oftware bundles the opperation of all
a of the
freeze-dryying functio
ons and ass sociated adm
ministrative tasks in on
ne uniform
user interrface. The fo nctional areas are coveered:
ollowing fun
Prrocess contrrol
Vissualisation
Prrocess reco rding (meas surement data and auddit trail)
Prrocess docu umentation
Daata backup
Ad
dministration grams/recipees
n of freeze--drying prog
Usser administtration
The "Prog gram" mode e offers the opportunity y to let the ffreeze-dryin
ng process
run in an automated manner un nder reprodu ucible cond itions. The freeze-
drying pro ograms/reciipes for this s purpose are also creaated, edited d, and
managed by way of tthe LPCplus software. They T are higghly configuurable and,
thereby, enable
e a cu
ustomised adaptation
a o the freezinng and drying
of
characterristics to thee product in question. Various
V optiional monitooring
paramete ers enable th he system to t react automatically tto deviations during
the proce ess run, therreby ensuring the optim mum protecction of the product.
p
There is also
a a "Mannual" mode for the deve elopment annd optimisa ation of
processes.
An anima ated schema atic system diagram visualises thee status of the t
individual freeze-drye er compone ents. The se et and actuaal values ca an be
displayed d in numericcal or graphical form. Process
P messsages are displayed
in pop-up p windows. A Alarms are displayed as a plain textt in an alarmm list and
they mustt be acknow wledged by the user. In n addition, aall message es and
alarms as s well as thee informatio
on concernin ng the proggress of the process
and user intervention ns are entered into the process evvent list (audit trail)
together with
w a time stamp. The e process ev vent list alsoo includes the
t values
of all of th
he paramete ers. Apart frrom the con ntinuous reccording of th he
measurem ment valuess, the value es of selecte ed sensors ccan also be e entered
into the process eve nt list at inte ervals that can
c be definned as desiired.
All of the process da ata (process s event list and
a measurrement valu ues) are
written intto a shared record file in binary fo orm. During this proces ss, they are
compress sed by way of a specia al algorithm in order to eensure optimum data
integrity. The origina al data can be
b viewed, printed, or eexported on nly via the
documentation functtion of the LPC L plus softw ware.
The LPCplus p user admministration with six configurable, hierarchic useru levels
enables a highly spe ecific access s managem ment.
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SCADA Softw
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1 General informatio
on
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1.2 C
Conformity with 21
2 CFR P
Part 11
The LPCplus
p software
e was developed in acccordance w
with the regu
ulation
21 CFR Part
P 11 of th he US Foodd and Drug Administrat
A tion (FDA) on
o
electronic nd electronic signatures:
c records an
The LPCplus softw ware can on nly be used after the suuccessful
authentication of the user, i.e. after the correct inpuut of the user name
and password (th he password d cannot bee read durinng the input). The
minimmum length o of the passwword, its validity periodd, the numbber of
unsucccessful log--ins before the blocking of the useer account (can( be
unbloccked by the e administraator only) as
s well as thee time of inaactivity up
to the automatic log-out are all defined by the adm ministrator. The
T current
user and
a countdo own timer up to the auttomatic log--out are perrmanently
ayed on the screen.
displa
Every user is asssigned to on ne of six hie
erarchic useer levels, wh hich
enablees a highly specific acc cess manag gement. Thee functionality that is
availa
able on a ce ertain user le
evel can bee specified bby the systeem
adminnistrator. A hhigher user level includ
des all of thee rights of the
t level
beloww. The followwing user levels are available (ord er by a dec creasing
scopee of rights):
Ad
dministratorr (6)
Ca
alibration (5)
Ma
aintenance (4)
En
ngineer (3)
Us
ser (2)
Gu
uest (1)
The LPCplus softw ware creates s exactly onne record fille per proce ess. The
softwaare records all of the binary process data, thee events tha at occur
duringg a freeze-ddrying proce ess as well as
a all of thee alarms, me essages,
and us ser intervenntions togetther with a time stamp in chronolo ogical
order, thereby cre eating a complete audit trail. The data and ev vent
recordding processs cannot be e influencedd by the useer.
In order to ensure e the data integrity of the processs record file,, the binary
stringss that are re
eceived by the PLC are e written intto the recorrd file in
binaryy form togetther with a checksum.
c In addition, the log files
s are
autommatically paccked by way y of a special data com mpression lo ogarithm
that is
s implementted in the LPCplus softw ware. This foormat canno ot be read
or unppacked by a any other co ompression tool that is available on o the
marke et.
The LPCplus softw ware include es procedurres for the bbackup of process
recordd files on saafe storage devices. All of the drivees/directories that are
acces ssible via thee operating system can n be used aas backup ta argets.
The qualification process of the freeze-dryer includdes the LPC Cplus
softwaare and the PC hardwa are in order to ensure tthe highest level of
precission, reliabil ity, and con
nsistent perfformance.
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SCADA Softw
ware LPCpluss
2.1 Fun
ndamental principles
s
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2 Sys
stem co
ontrol and proc
cess mo
onitoring
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7 @2@1
2.1 Fundamental prin

nciples
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2.1.1 L
LPCplus scrreen
The LPCplus
p screen iss divided into three are
eas: the "tooolbar", "stattus bar",
and "work
k area".
Fig. 1 LPC
Cplus screen
The "toolb bar" on the right-hand side of the screen is thhe central control
area. The e buttons in the lower half
h of the "ttoolbar" aree used to ca all up the
individual functional areas of the e software. In general, after a buttton has
been click ked, a correesponding window
w opeens in the "w work area" ofo the
screen. This
T windoww offers detaailed functio
ons. Severa l windows can c be
open simultaneouslyy in the "worrk area" where they caan be scaled d and
positioned d as desired d. In the be
eginning, all of the winddows are op pened in
their max ximised formm. In order to maximise e a minimiseed window so s that it
fills the working
w area
a completely all it up oncee again via the
y, simply ca
correspon nding button n. When the e button "Seelect Unit" iss clicked brriefly, all of
the windo ows that are e open in the "work are ea" are cycliically activaated or
brought to o the foregrround.
Some win ndows (e.g. "Process Recording")
R require thee user to complete
his/her wo ork within thhem before they can co ontinue withh the operation of the
system. These
T windo ows are nott opened in the "work aarea", but on a plane
in front off the LPCpluss screen. Att the same time,
t these windows block the
LPCplus sc creen until tthey are clo
osed again.
If several freeze-drye ers are connected to thhe SCADA PC and if processp
recording g processess have been n started for these unitss (there are four virtual
ports who ose data are e administeered in sepaarate areas)), holding the button
"Select Unit" for a lon nger periodd of time (> 3 seconds) enables the user to
switch to another fre eeze-dryer via
v a selection dialog.
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2 System control and process monitoring

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In this casse, the systtem automa atically open ns a new wiindow with the t
associate ed schematiic system diagram in th he foregrou nd and it up pdates the
"toolbar" and "statuss bar" accordingly. These two barss as well as the
buttons inn the middle e section of the "toolbar" always reefer to the freeze-
f
dryer thatt is displaye ed in the winndow that is s currently aactive (i.e. in the
foregroun nd) in the "wwork area" (in the follow wing, this freeeze-dryer is referred
to as the current free eze-dryer). If, for example, the schhematic sys stem
diagram of o freeze-drryer x is in the foregrou und, clickingg the button "Process
Graphics"" would ope en the windo ow for precisely this freeeze-dryer. Even if
windows of various d eze-dryers are open, thhe brief actuation of
different free
the "Selec ct Unit" buttton cyclically activates all of the o pen window ws and
brings theem to the fo oreground while,
w at the same time , the "toolba ar" and
"status baar" are upda ated accord dingly.
When one e of the "Do ocumentatio on", "Backup", or "Extraas" buttons is clicked
and if there are seve eral configurred ports orr ports that ccontain data, a dialog
for the seelection of thhe data sou urce opens. The buttonns "Documentation"
and "Extras" offer the e additional data sourc ce "USB-Stiick" that is managed
m
as a fifth port, which means that it may con ntain importeted record fiiles that
are made e available o offline.
The butto ons "Steam Pressure", "Help", and d "Info abouut " offer system-
s
independent informa ation. The button "Process Recordding" at the head of
the "toolbbar" provide s the option ns "Start Reecording", "S Stop Recorrding", as
well as thhe input of " Batch Data" separately y for each oof the conne ected
freeze-dry yers. The b button "Alarm m active"/"AAlarm listed"", which is only
o
displayed d if at least o
one alarm is s present or if at least oone acknow wledgment
still needss to be mad de concerning one of th he connecteed freeze-dryers,
provides information concerning g the alarm status of alll of the free eze-dryers.
(a) This s button opeens a windoow with seve eral
func ctions for sta
arting and sstopping thee
proc cess recording processs separately y for
each h of the connnected freeeze-dryers anda
alsoo for the input of batch ddata concerning
thes se process records.
r A ddark blue frame
arou und the buttton indicatees that at lea
ast
one process recording proocess is actiive.
(If th
he access protection
p inn the LSCplus
conttrol system of a conneccted freeze-
drye er is active, a user withh the
corrresponding rights mustt be logged in for
startting or stopping the proocess recorrding
proc cess or for entering
e thee batch dataa.)
(b) Currrent date an
nd time of thhe SCADA PC.
(c) Indic
cators conccerning the ccommunica ation
betwween the SCCADA PC aand a maxim mum
of fo
our freeze-d
dryers that aare connectted
via the
t ports 0 3.
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(d) Brief actuattion:

The window ws that are open in the e "work areaa" will be
cyclically acctivated or brought to the
t foregrouund. The
"toolbar" annd "status bar"
b will be updated
u acccordingly.
Long actua ation (> 3 seeconds):
Selection oof one of thee other conn nected freezze-dryers by
way of a dia alog, and opening of a new windoow with the
associated schematic system diagram in thee foreground d.
The "toolba ar" and "stattus bar" willl be updatedd according
gly.
(e) Name of th e freeze-drryer to which h the currennt window (i.e.
the window t "work arrea" refers and,
w in the foreground) in the
therefore, aalso the nam eeze-dryer to which the
me of the fre
informationn in the "stattus bar" and
d the buttonns in the are
eas
(f) and (g) rrefer.
(f) Start or sto
op of the opeerating mod de that has been
preselected d for the currrent systemm under "Prrocess Conttrol"
(a dark bluee frame aroound one of the two butttons indica ates
the current operating status,
s see also "statuss bar").
(These butttons are only available e if a freeze--dryer is
connected and if the process
p ording proceess is active. If
reco
the access protection in the LSCplus p control ssystem of th
he
freeze-dryeer is active, a user with the correspponding rights
must be log gged in.)
(g) These butto ons are use ed to call upp certain funnctionalities of
the current freeze-drye er. A corres sponding wi ndow with the t
detailed funnction then opens. (The ese functionnalities are only
available if a freeze-drryer is connected and iif the proces ss
recording fuunction is active.
a If the access prootection in thhe
LSCplus con ntrol system
m of the freeze-dryer is active, a us ser
with the corrresponding g rights mus st be loggedd in for channging
the settingss or for execcuting the fuunctions in the window w.
The "User A Administrattion" is only available aafter the log--in of
a user if the
e access prrotection is active.)
a
(h) These butto ons are use ed to call upp the functioonalities of one
o
of the portss (provided that they arre configureed and actually
include datta) and for immported offfline data byy way of a
selection diialog. The program
p will automaticaally open a
correspond ding window w with the as ssociated ddetailed
functions. ((These func ctionalities are
a also avaailable if no
freeze-drye er is conneccted and als so if the pro cess record ding
function is nnot active. If
I the acces ss protectionn in the LSC Cplus
control systtem of the freeze-drye
f r is active, a user with the
correspond ding rights must
m be logg ged in for chhanging the e
settings or for executin ng the functtions in the window.)
(i) These buttoons are use ed to call up
p device-inddependent
information
n. (This inforrmation is always
a availlable, also
without a u ser log-in.)
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(j) Alarm indiccator and bu

utton for calling up a deetailed list of
o all
of the alarm
ms of the co
onnected freeeze-dryerss (see "Alarm m
list").
"Alarm activve" At least one unacknowle
u edged alarm m of
(red, flashinng): on
ne of the connected freeeze-dryers..
"Alarm activve" Onne or severaal already aacknowledged
(red, static)): ala
arms of the connected freeze-drye ers.
"Alarm listeed" Noo pending alarm,
a but att least one
(red, flashinng): un
nacknowledged alarm oof one of the
co
onnected freeeze-dryerss.
Button Noo pending or
o unacknow wledged ala arms
hidden: of the conneccted freeze--dryers.
(If the acce
ess protectio
on in the LS
SCplus controol system off one
of the conn
nected freezze-dryers is active, a usser with the
e
correspondding rights must
m be loggged in for a cknowledgiing
the alarms..)
Fig. 2 "To
oolbar"
The "statu us bar" at th

he bottom of
o the screen provides information
concernin ng the statu s and operaating mode of the freezze-dryer as well as the e
progress of the proce ess, the use
ers that are currently loogged in, annd the time
until their automatic log-out. Clic
cking the sttatus bar leaads to the im
mmediate
log-out off the currentt user from the SCADA A system.
(a) System staatus:

"Run"/"Stanndby" (see also "Toolbar")
(b) Operating m
mode:
"Manual"/"P
Program"
(c) Current pro
ocess phasee:
"Freezing"//"Warm Up""/"Main Drying"/"Seconndary Drying
g"
(d) Additional ttasks that is
s currently being
b perforrmed:
e.g. "Press ure Increas se Test"
(e) Freeze-dry ing program
m/recipe tha
at is currenttly being
performed, and the current progra
am/recipe ssection
(f) Elapsed tottal process time and se
ection time (alternating
g
every 10 se
econds)
(g) User who iss currently logged-in
l and the counntdown until the
automatic l og-out in th
he event of inactivity
i (seee chapter 3.1.1
- "Safety se
ettings"). Clicking
C the "status barr" leads to th
he
immediate log-out of th he user.
Fig. 3 "Sta
atus bar"
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2.1.2 U
User log-in
n and proc
cess recorrding
Before it is
i actually p
possible to start
s a freez
ze-drying prrocess via the LPCplus
user interrface, the prrocess reco
ording function must bee activated so s that the
buttons in
n sections (ff) and (g) off the "toolba
ar" become available.
Click the button "Pro ocess Recorrding" (A) at the head oof the "toolb bar" in
order to open
o the winndow "Proccess Record ding". For eaach of the maximum
m
of four co
onnected fre eeze-dryerss, this windo ow includes a series of buttons forr
starting and stopping g the processs recording g for the asssociated fre
eeze-
dryers. In addition, bbatch inform
mation ("Batc ch Data") caan be colleccted.
Fig. 4 Sta
art of a Processs Recording process
If the access protect ion is active
e in the LSCCplus control system of the
t
connected freeze-dryyer, the use er will be req
quested to log in after the button
"Start Reccording" (a)) has been clicked.
Fig. 5 "Us
ser Login"
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After the authenticat ion of the user by way of the userr ID and ass sociated
password d, either thee window "P Process Rec cording" willl be displayed once
again andd the button n "Start Rec cording" (a) must be cliccked, or thee process
recordingg process w ill be started d immediate ely. This deepends on the "User
Administrration" settinngs (see ch hapter 3.1.1 - "Safety ssettings").
In order to
o protect th e system frrom manipulation by unnauthorised d persons
when leav ving the wo orkplace, the e user can log out by cclicking the "status
bar". The yellow area a of the "sta
atus bar" thaat includes the user na ame and
log-out co
ountdown w will then disa
appear. The e log-out alsso occurs
automaticcally if the u
user does no a operatioon during th
ot perform any he
countdow wn (see cha pter 3.1.1 - "Safety settings"). W When a butto on that
requires an
a authenticcation is clic cked, the lo
og-in screenn will be opeened once
again.
After the start of the process rec cording funcction, the firrst window that is
opened iss a "Batch D Data" windo ow. It provides a form foor entering descriptive
data conccerning the current batch.
Fig. 6 Ba
atch Data" scre
een
The scree en can be cconfigured sos that the data
d of the pprevious pro
ocess will
be taken over. In add dition, the names
n e available batch data input fieldss
of the
can be cuustomised (ssee chapter 3.4 - "Extrras").
Until the completion
c of the curre
ent process recording pprocess, the e "Batch
Data" winndow can be e called up any time by y clicking thhe buttons "Process
Recording g" (A) - "Ba tch Data" (c
c) in order to edit the fi elds.
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Fig. 7 Callling up the B

Batch Data win
ndow during a running proccess recording
g process
After the process hass been com mpleted and if no other operation via
v the
"Process Control" syystem is reqquired and no
n additionaal informatio
on
concerninng the curre
ent batch must be entered, the proocess recording
c be stop ped. To do so, open th
process can he "Processs Recordingg" window
once again via the b utton of the
e same namme (A) on thee toolbar an
nd click the
button "Stop Record ing" (b).
Fig. 8 Sto
opping a "Proccess Recording" process
The recorrd file (in bin b packed bby way of a special
nary formatt) will then be
compress sion algorithhm. This forrmat cannott be read orr decompres ssed with
any comp pression too ol that is ava
ailable on th
he market, tthereby ens
suring the
integrity of
o the data.
Process record
r files can be view wed or printted only via the "Docum
mentation"
function of
o the LPCpllus software (see chapte er 3.2 - "Do
ocumentation").
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2.1.3 V
Visualisation, alarms, and sys
stem inforrmation
After a prrocess reco rding proce
ess for a con
nnected freeeze-dryer has
h been
started annd the batch
h data inputt window haas been clossed, the schematic
diagram for
f visualisin
ng the freez
ze-dryer is brought
b to tthe foregrou
und.
(a) Process meessage in a pop-up win ndow. At thee same time, a

correspond
ding entry is
s written into
o the processs event list.
(b) Information
n concerningg the visualisation elem
ments is dis
s-
played wheen the mous se pointer is
s placed on the elemennts:
Name off the object
Referencce designator
Pending alarms (if applicable).
a
(c) Value displ ays for che
ecking the se et and actu al values. (AAfter
the button ""Actual Valu s been clickked, the required
ues" (3) has
displays caan be selectted from a liist and placced freely in
n the
visualisatio
on window by
b drag&dro op.)
(d) Automatic vvalves (sole
enoid or pne
eumatic valvves):
Grey: closed
Green: open
(e) Freeze-dry er compone ents (refrige
eration unitss, vacuum pumps,
p
circulation p
pumps, hyd draulic pumps, heaters , etc.):
Grey: off
Green: on
Red, flashinng: At least one pending, unacknoowledged alarm
(further information can be acccessed by
calling up
u the "alarm m list" via thhe alarm ind
di-
cator button at the lower end oof the toolba ar)
Red, static:: One or several
s pending, alreaddy acknowle edged
alarms (further
( information cann be access sed
by calling up the "alarm list" viaa the alarm
indicatorr button at the
t lower ennd of the too olbar)
Fig. 9 Visualisation win
ndow (schematic system dia
agram)
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The comp ponents and d units of th

he freeze-drryer are dispplayed in th
he high-
resolution n visualisatio
on window as animate ed icons thaat indicate th
heir
respective e status in rreal-time.
In order too view the sset and actu ual values, a wide rangge of value displays
can be po ositioned fre
eely in the visualisation
v n window. T To do so, cliick the
"Actual Values" butto on (3) and select
s the desired displlays from a list. The
value disp plays that aare then disp played in the visualisattion windoww can be
positioned d by drag&d drop. If an actual
a valuee is beyond the measuring range
(e.g. if a sensor
s is de
efective or not
n connectted), the proogram will in ndicate this
by display ying "---".
Regardless of the wiindow that is currently active or shhown in the

foregroun nd, the prog
gram always s displays thhe messagees and alarm ms of all of
the conne ected freeze e-dryers.
Process messages
m ((e.g. the res
sult of a leak test) are ddisplayed se
eparately
in pop-up p windows. A At the same e time, a correspondingg entry is written
w into
the proce ess event lisst together with
w a time stamp.
s Proccess alarms s (e.g. if
the safety y pressure i s exceeded d) and hardw ware alarmss (e.g. an overload
o
alarm con ncerning a u unit or comp ponent) aree displayed in a collectiive "alarm
list" that also
a opens iin the foreg ground when never an alaarm is issueed.
(a) Date and ti me of the la

ast occurrennce
(the data co
oncerning every
e individ
dual occurreence and
elimination can be found in the prrocess evennt list)
(b) Alarm ID
(c) Freeze-dry er in which the alarm has
h occurreed
(d) Alarm statu
us:
P pendinng
A acknoowledged
(e) Alarm text
(f) Frequency of occurren
nce since th
he last acknnowledgeme
ent
Fig. 10 "Allarm List" (min
nimised windo
ow)
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By clickin
ng the colum mn headers of the "Alarrm List", thee alarms ca an be
sorted in ascending or descending order ba ased on thee content off the
respectivee column.
Alarms must
m be ackn nowledged by the userr. When all oof the pending alarms
have been acknowle edged, the sound
s al will be deaactivated until a new
signa
alarm is is
ssued.
The alarmm indicator ((Q) at the loower end off the toolbarr also indicaates that
there is at least one pending ala ast one alarrm that still needs to
arm or at lea
be acknow wledged. "A Alarm active e" flashes re
ed as long aas at least one
o of the
pending alarms
a has not been ac cknowledge ed. Followinng the
acknowle edgement off all of the pending
p alarms, "Alarmm active" will be
displayedd statically in
n red. If the
ere is no pennding alarmm but at leasst one
alarm has s not been a acknowledg ged yet, "Alaarm listed" fflashes in red. The
alarm indicator is alsso the button via which the "Alarm m List" can be
b called upp
in order to
o obtain infoormation ab bout any pending or unnacknowledged
alarms.
The "Info"" button (2) at the lowe er end of thee "Alarm Lisst" can be used
u to
display th
he following information n concerning the alarm m that is marrked on the
list:
Possib ble cause o of the alarm
Possib ble consequ uences
Measu ures for elim
minating the e cause
Refere ence indica ator of the afffected commponent
Fig. 11 - "Alarm List" - "In

nfo"
The buttoon "Message e beep on/o off" (3) can be used to deactivate and
reactivatee (dark blue
e frame) the e alarm soun nd signal foor this SCADDA PC.
The soun nd signal is aalways activ ve when the e LPCplus sooftware is (rre)started.
In order to
o acknowle edge an alarrm (regardle ess of its freequency of
occurrenc he "Quit" buutton (4). Clicking the
ce), select itt on the list and click th
"Quit All" button (5) a
acknowledg ges not only y the selecteed alarm buut also all
of the oth
her alarms o of the assoc ciated freeze e-dryer.
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Every alaarm leads to o three entries into the process eve vent list: one
e when it
occurs, one when it iis eliminate ed, and one when it is aacknowledg ged.
In order to
o identify a faulty unit or
o compone ent immediaately, the ico ons in the
schematic c system di agram also o have alarm m indicatorss. These ala arm
indicators
s light red (fflashing or static)
s in ord
der to indicaate alarms concerning
c
the respeective unit o r componen nt. When the mouse poointer is mo oved over
the indica
ator, the nam me of the unit or component, its reeference ind dicator,
and also any pending g alarms arre displayed d.
The buttoon "Unit Info

o" (2) below
w the schematic system m diagram is s used to
view inforrmation conncerning the yer that is diisplayed in the
e freeze-dry
diagram:
Fig. 12 - "U
Unit Info"
The follow
wing piecess of informattion are liste ed:
Port th hat is used for this freeeze-dryer
Name e of the freeeze-dryer
Unit iddentificationn
Unit tyype
Serial number
Softwa are version of the LSC Cplus control system of thhe freeze-d
dryer
IP add dress of the e LSCplus control system m of the freeeze-dryer
Comm munication p port
Data folder
f (direcctory) on the
e SCADA PC P
Subdirectory for tthis port
Option ns concerniing the freeze-dryer
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2.1.4 P
Process Graphics
During a running proocess, it is always
a posssible to clickk the button "Process
Graphics"" (H) on the
e "toolbar" in
n order to display the ddevelopmen nt of
selected measurand
m s over timee.
(a) Timeline: T
The total lenngth of the timeline reprresents the
recording tiime that hass elapsed so
s far. The aarea that is
marked in ggrey indicattes the position and lenngth of the
period that is currently
y displayed in the graphh.
(b) Arrow butto
ons: They can be used to shift thee period thatt is to
ed in the dirrection of the start of thhe recording
be displaye g
process or in the direc
ction of the present
p poinnt of time.
his line can be used to read off preecise
(c) Hairline: Th
measureme ent values on
o the graph.
(d) Arrow butto
ons for positioning the hairline.
(e) Value tablee: Apart fromm the curren nt values off the
measurand ds that are represented
r d on the graaph (right-ha and
column), thhis table also o includes their
t respecctive values at
the point off time that is
s marked by y the hairlinne (left-hand
d
column).
Fig. 13 P
Process Graph
hics
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Measurement value e assignme ent: Via "Me

easured Vaalue" (5), the
e
measuran nds that are
e to be displayed are assigned to tthe 12 chan nnels (pen
colours) of
o the softwaare plotter.
Fig. 14 - "Process Graph

hics" "Measu
ured Value"
The labelling of the bbuttons (i) (xii) next to the pen ccolours indicates the
measuran nds that aree currently assigned
a to the colourss. In order to
o assign a
different measurand
m to one of th
he colours, click the coorresponding button
and selec ct the desire
ed measura and from a list.
Since the
e measurem ment values are written into the proocess recorrd file and
since the graph is ge
enerated ba ased on these values, tthe channel
assignmeent can be cchanged an ny time durin
ng a runningg process. It is also
possible to
t select a d
different asssignment affter the com
mpletion of the
t
NO
OTE process in order to p
print the pro
ocess docummentation (ssee chapterr 3.2 -
"Docume entation").
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Scaling: "Scaling" (4
4) is used fo
or the config
guration of tthe ordinate
e axes.
Fig. 15 "P
Process Graph
hics" "Scalin
ng"
The left-hhand area o of the window shows the pressure//vacuum sc cale. The
button "loog"/"lin" (i) ccan be used d to switch between
b loggarithmic annd linear
scaling within
w the de ecades. The e labelling of the buttonn shows the current
setting. Regardless
R o
of this, the arrow
a buttons can be uused to expand
individual decades in n order to in ncrease the resolution in this area. Clicking
the buttonn "Default" ((ii) resets th he scale to uniform
u logaarithmic or linear
scaling ov ver the entirre range.
In the righ
ht-hand are ea of the win ndow, all thee other scalles can be configured.
c
The labelling of the b button indicates the sca ale that is ddisplayed att present.
The arrow w buttons ca an be used to change the upper aand lower en nd of the
scale. Clicking the bu utton (iii) en
nables the user
u to sele ct a differen
nt scale for
editing fro
om a list.
Time range (period ) to be disp played: The e button "Tiime Range"" (3) can be e
used to adjust the le ngth of the part of the total recordding period thatt is to
be display ng the button repeatedly calls up thhe possible
yed. Clickin e values
(5 min, 100 min, 30 m min, 1 h, 12 h, 24 h, 1 week,
w max. = recording g time that
has elapssed so far) i n a cyclic manner.
m Thee current seetting as we ell as the
date and time of the start of the recording process
p aloong with the time that
has elapssed so far a are displayed on the tim meline (a) beelow the gra aph. The
arrow butttons (b) on the left and d right of the
e timeline ccan be used d to shift
the periodd that is to b
be displayed in the dire ection of thee start of the
e recording
process oro in the direection of the
e present po oint of time.. The position and
length of the period rreferred to the
t time tha at has elapssed so far is s
representted by the g grey sectionn of the timeeline. The a rrow button ns are only
available if the period d is not pos
sitioned at th
he start or eend of the recording
time. Alte
ernatively, thhe period caan be positioned anyw where on the e timeline
by clicking the timelin ne and draggging the pe eriod with thhe mouse button
b
pressed tot the new p position.
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Zooming g: The "Zoom m" button (22) can be used to zoom m a certain section of
the proceess diagram m so that it fills the display area com mpletely. Clicking the
button traansforms the e mouse po ointer into a hand symbbol with a pointing
finger. In addition, a dark blue frrame around the buttonn indicates that the
zoom mode is active e. The area that is to be e zoomed ccan then be selected
by dragging a frame around the e desired are ea while keeeping the mouse
m
button pre essed. Whe en the mous se button is released, tthe selected d area will
be zoome ed. In orderr to increasee the zoom factor, this process can be
repeated.. If the "Zooom" button is clicked ag gain, the zooom mode is s
deactivate ed. Clicking
g the button "Original" (1)
( leads thee user back k to the
standard view of the total record ding. In this case, the zzoom mode e will be
deactivate ed automattically.
Fig. 16 - "Process Graph

hics" "Zoom""
Reading of measurrement valu ues: In orde er to read a measurem ment value

precisely on the grap ph at a speccific point off time, this ppoint of timee can be
selected with
w the aid d of the perppendicular, red hairlinee (c). The lin ne can be
moved to the desired d position by
b way of the e arrow butttons (d). Affter the
opening ofo the "Proccess Graphics" window w, it is still hi dden behinnd the scale
e
axis on thhe left. It cann be called up by clicking the rightt arrow buttton.
Alternativ
vely, the line e can be alsso positioneed anywheree on the gra aph by
clicking th
he graph an nd by dragging the line to the desi red position n with the
mouse bu utton presse ed.
It may be necessaryy to deactiva

ate the zoom
m mode prioor to positio
oning the
red hairlin
ne (see abo
ove, "Zooming").
NO
OTE
The value es of the meeasurands that

t are rep
presented onn the graph h at this
point of time can the o the table (e) next to the graph. The left-
en be read off
hand colu umn include es at the selected pointt of time while the
es the value
right-handd column sh hows the cu
urrent value
es.
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Printing the
t proces ss diagram: Apart from m the actuall print functiion, the
button "Print" (6) also o offers a correspondin ng print prevview as well as the
output in PDF. In add dition, the underlying
u raw processs data can beb exported
into otherr programs in various different
d form
mats for furt
rther evalua
ation.
If, at pres
sent, only a section of the
t process recording iis displayed d, the user
must decide after h having click ked the "Prin
nt" button whether on nly this
period (i) or the entirre recording g period up to the preseent point of time (ii) is
to be prinnted. Corresspondingly, when exporting the raw w process data,
d only
the data ofo the seleccted period or o the data of the entiree recording period will
be outputt.
Fig. 17 "P
Process Graph
hics" - "Print" period selection
Then, the
e print dialog
g field open
ns.
Fig. 18 "P
Process Graph
hics" - "Print"
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The butto
ons "Printer"" and "Preview" (i) are used to preeselect the output
o
device (printer, moniitor) (select "Preview" for
f the outpput in PDF and
a for the
export of raw processs data).
Printer: Click
C the buttton "Printerr Setup" (ii) to select a specific printer and to
perform printer-spec
p cific adjustm
ments. When n the "Printeer" has been
preselected, there arre various additional
a opptions (num mber of copies, sorting
("Collate""), and doubble-sided prrinting ("Dup plex")) (iii).
Preview: The preview w offers butttons for scrrolling (1-4)), zooming in/out (7-
10), printiing (6), as w
well as for th
he output in
n PDF and ffor the expo ort of the
raw proce ess data (5)).
Fig. 19 "P
Process Graph
hics" - "Print" "Preview"
Save as: The button "Save As" (5) can be used to savve the proce ess
diagram in PDF or to o export thee raw proces ss data for ffurther evaluation in
MS Excell, SQL, XM ML, or HTML L format to any desiredd directory. After the
selection of the desirred file form
mat by way of o the butto n (iii), the ta
arget
directory that has beeen used mo ost recently mat will be suggested.
y for this form
A differen
nt target dire
ectory can beb specified d by way of the drive/directory
selection box (i). Thee button "Ne ew Folder" (ii) on the riight can be used to
create a new
n within the directory that is selectedd at present. The
folder w
t export fiile will be ge
name of the enerated auutomaticallyy based on the name
of the pro
ocess record d file and th
he prefix "Acct_Graph_" . The file ex xtension
depends on the sele ected file forrmat.
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Fig. 20 "P
Process Graph
hics" - "Print" "Preview" "Save As"
Clicking the "OK" bu tton starts the
t storage process. If there is alrready a file
of the sam
me name in n the target directory, a correspondding messa
age will be
displayedd in a pop-u p window.
e button "Prrint" (6) can be used to print basedd on the pre

Print: The eview.
Fig. 21 "P
Process Graph
hics" - "Print" "Preview" "Print"
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2.1.5 P
Process ev
vents
Apart from
m viewing th he temporal development of seleccted measurands in
graphical form during g a running process, it is also posssible to calll up the
process event
e udit trail) via
list (au a the button
n "Process E
Events" (G)) on the
toolbar. The
T list provvides detaile ed information concernning the progress of
the proceess.
Fig. 22 - "Process Eventss"

The follow
wing setting
gs and even
nts are listed
d in chronollogical orde
er:
Start and
a end of tthe process s recording process toggether with the file
name
Versioon of the op perating sys stem of the SCADA
S PC
C
Versioon of the SC CADA softw ware CHRIS ST LPCplus
Unit id
dentificationn (type, control system, software vversion)
Serial number of the unit
Current password d settings (aaccess prottection (on/ooff), time unntil
autommatic log-outt, period of validity, min nimum lenggth, and perrmissible
numbe er of log-in trials)
Current setting co oncerning the regular entry
e of the values of the
selectted measura ands into thhe event listt (see below w: "Cyclic evvents")
User log-ins and log-outs
All of the
t user acctivities (mod de preselec ction, phasee preselectio on,
parammeter chang ges, process s start, stop
p, cancel, ettc.)
Param meters of the e freeze-dry ying phases s for the "MManual" mod de or the
numbe er and nam me of the sellected freez ze-drying prrogram/recipe with the
parammeter sets o of all of the program
p sections and tthe additionnal set
values s or parame eters of the auxiliary prrocesses at the start off the
respective mode and at every paramete er change
t events tthat were generated du
All of the uring the prrogress of thhe process
All of the
t messag ges and alarms (the lattter togethe r with entrie es
conce erning their ooccurrence, acknowled dgement, a nd elimination)
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The follow
wing additio
onal entries are optiona
ally possiblee:
Notes
s that were aadded by th
he user
Values of selecteed measurands, entere
ed at regula r intervals (see
( below:
"Cyclic events")
Date infoormation: T The button "Date

" Inform
mation" (1) oonly affects
s the
representtation of the
e list on the screen. It is
s used to deefine whethher the date
is to be displayed in the first column of the list "in eachh process event
e line"
or "for date changes only" for a better overrview in the case of lon ng
processes. The labe cates the cuurrent setting.
elling of the button indic
Adding a note: The e button "No

ote" (3) enabbles the useer to write a note into
the eventt list. The nootes are auttomatically preceded bby a time staamp and
the word "Note".
Cyclic evvents: In ad ddition to the graphical output of thhe values of

o selected
measuran nds, it is alsso possible to enter thee numerical values of th hese
measuran nds at regullar intervals s into the process evennt list (see chapter
c 3.4
- "Extras"").
Printing parameters s: The butto

on "Printing
g Parameterrs" (4) can be
b used to
influence the layout a
and scope of
o the hardccopy.
Fig. 23 - "Process Eventss" - "Printing Parameters"

P
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Clicking the buttons (ii) to (vi) ac

ctivates or deactivates
d the followin
ng options
(dark bluee frame):
Coloured represe entation of different
d enttries
Date in every eve activated = only when tthe dates changes)
ent line (dea c
Printin ng of set va lues (e.g. password
p se
ettings, settiings for "Cy
yclic
Events", set valu es for "Man nual", set va
alues for "Prrogram", se et values of
the auuxiliary proccesses)
Printin ng of valuess of selected d measuran nds that aree entered att regular
interva
als ("Cyclic Events")
Printin ng of "Leak Test" entrie es
Clicking the button (ii) once or twwice activates or deacttivates all off the
options toogether.
Printing of process s events: Apart from th he printing oof the proce

ess event
list, the "P
Print" button
n (5) also offfers a corre
esponding ppreview and d the
output in PDF underr "Preview" - "Save As".
Fig. 24 - "Process Eventss" - "Print"

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2.1.6 P
Process co
ontrol
When a process
p reco
ording proc
cess for a co
onnected freeeze-dryer has been
he window ""Process Control" with the operatiing function
started, th ns for this
freeze-dryyer can be called up by e button of tthe same name (F).
y way of the
Fig. 25 "P
Process Contro
ol" (here: "Manual" mode prreselected)
From here, it is posssible to paraameterise, start,
s or stopp the freezee-drying
phases "FFreezing", ""Main Drying g", and "Secondary Drrying" manu ually or to
let them run
r controlle ed by a pred defined use er program/rrecipe. The e auxiliary
processes "Aeration"", "Defrostin ng", "Leakage Test", annd "Media Drain" D are
also parameterised a and activate ed via this window.
w If thhe access protection
p
in the LSCCplus controll system of the freeze-dryer is acttive, a user with the
corresponnding rightss must be lo ogged in.
In the "Standby" stattus of the freeeze-dryer, the type off process th hat is to be
started must
m be presselected by way of one of the "Modde" buttons s in the left-
hand partt of the "Proocess Contrrol" window. The preseelected mod de is
marked byb a light bluue frame aro ound the co orrespondinng button. The
executionn of this mod de will not start
s until the freeze-dry ryer is the "R
Run"
status.
The layou gger, right-hand area off the window
ut of the big w depends on the
preselected/active m mode (see chapter 2.2 - "Manual ffreeze-dryin ng" bis
chapter 2.6
2 - "Perforrming a lea ak test"). In this area, tthe parameters of the
corresponnding mode e are set and displayed d. If the "Maanual" mode e is
preselected, the freeeze-drying phase
p that iss to be execcuted must be
preselected in this arrea by clickking one of thet "Processs Phase" buttons.
After the adjustment of the para ameters or after
a the sellection of thhe freeze-
drying pro
ogram that is to be exe ecuted, the system musst be switch hed from
"Standby"" to "Run" b by way of thhe "Run" buttton. As a reesult the da ark blue
frame switches from the "Standby" button to t the "Run"" button. At the same
time, the frame colou ur of the "Mode Presele ection" buttton changes s from light
blue ( = preselected)
p ) to dark bluue ( = activee).
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In the "Ruun" status, ccertain modde changes (e.g. from ""Program" to t

"Manual")) are also ppossible. The buttons of the modess that are not possible
in the currrent operat ing state off the freeze--dryer are ggreyed out.
Clicking the "Standbyy" button ab borts a runn
ning operatiing mode. TheT dark
blue fram
me switches back to the e "Standby" button and the "Mode
Preselecttion" button is once aga ain displaye
ed with a ligght blue fram
me.
Printing of set valu es: Apart frrom the prin

nting of the set values of the
modes that are not ccontrolled by m/recipe, thee "Print" button (2)
y a program
also offerrs a corresp
ponding prevview and the output in PDF underr "Preview"
- "Save As".
A
Fig. 26 - "Process Contro

ol" - "Print"
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Options: The "Optio ons" button (3) can be used

u to perrform variou
us general
adjustments concern ning the ope he freeze-drryer and depending on
eration of th
the unit ty
ype and its equipment and feature es.

ol" - "Options" (in this case of
o several freeeze-dryers)
Language e: After the button "Lan

nguage" (i) has been cclicked, the language
l
of the conntrol panel o
of the LSCplus control system can bbe changed d (a dark
blue fram
me around o ne of the bu uttons (i1) to
o (i3) indicattes the curre
ent
setting). The
T languag ge of the LP
PCplus user interface rem mains unafffected.

ol" - "Options" - "Language"
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Aeration medium
m pre
eselection: If the systemm is equippped with an automatic
aeration valve
v and aautomatic va alves for me
edia selectioon, the button
"Preselecction Aeratio on" (ii) can be used to preselect thhe medium that is to
be used for
f all of thee aeration media
m requests in the "MManual" mo ode (from
the start of
o the main drying proc n the "Aerattion" mode. The
cess) and in
phases "F Freezing" a nd "Warm Up" U in the "M Manual" moode and the e operating
modes "D Defrosting", "Leakage Test",
T and "Media Drainn" always use
u air for
the aeratiion. In the " Program" mode,
m the aeration meddium that is
s specified
in the addditional gen eral set values of the respective
r pprogram/reccipe will be
used (see e chapter 2..3.1 - "Crea ating/modiffying a freeeze-drying
program//recipe ").

ol" - "Options" - "Preselectio
on Aeration"
If the vacuum contro ol system off the freeze--dryer uses a controlled gas
inflow (ga
as injection)), the preselected medium will be used for this purpose.
The followwing media preselectio on settings are
a possiblee (a dark bluue frame
around on ne of the bu
uttons indicaates the currrent settingg):
Air: Prese
elects the media connection "Air".
Inert gas: elects the media connection "Inert Gas".

Prese
Automatic
c: Autommatic media n preselectioon depending on
a connection
the ch
hamber presssure:
Ch amber pres ssure 950 mbar:
Pre
eselection of
o the media
a connectionn "Air".
Ch amber pres ssure < 950 mbar:
Pre
eselection of
o the media
a connectionn "Inert Gas
s".
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Gas injecction: If the ffreeze-drye

er is equippe
ed with a prroportional gas
g
injection valve,
v the b
button "Gas Injection" (iii) can be uused to presselect the
vacuum control
c meth t be applied in the "Maanual" mode. In the
hod that is to
"Programm" mode, the e method thhat is specified in the addditional ge
eneral set
values of the respecttive program m/recipe will be used (ssee chapter 2.3.1 -
"Creatingg/modifying g a freeze-drying program/recip pe ").

ol" - "Options" - "Gas Injectio
on"
The follow
wing method ds are poss
sible (a dark
k blue framee around on
ne of the
buttons in
ndicates the
e current se
etting):
Off: The g as injectionn is deactiva

ated. Vacuuum control is
s ensured
solelyy by openingg and closinng the presssure controll valve
in the suction line
e of the vacuum pump..
Standard: Vacuuum control is ensured by b combineed evacuatio on and

gas in
njection. If th
he current vacuum
v is w
worse than the
t set
value,, evacuation n will be performed by opening the e
pressuure control valve. If it is
s better tha n the set va
alue,
gas w
will be injecteed by opening the propportional va alve.
Continuou
us: Vacuuum control is performed d continuouusly with a
permaanently opeen pressure control valvve solely by y
varyin
ng the injecttion flow witth the aid off the proporrtional
valve..
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Freeze-drrying processs: In the ca ase of laboratory systeems, the button

"Freeze-D Drying Proccess" (iv) is used to pre
eselect the ffreeze-dryin
ng method
that will be
b applied dduring the process.

ol" - "Options" - "Freeze-Dry
ying Process"
The follow
sible (a dark
ne of the
buttons in
ndicates the
e current se
etting):
Process A:
A Freezzing and dryying of the product
p in thhe ice conde
enser
chamb ber (single--chamber syystem).
Process B:
B Separrate freezingg, e.g. in a deep-freezee, and dryin
ng
outsid
de of the ice
e condenserr chamber, e.g. under an
attach
hed acrylic glass
g dome (double-chhamber systtem).
Process B Separrate freezingg, e.g. in a deep-freezee, and dryin

ng
+ LyoCub
be outsid e condenserr chamber i n an attached
de of the ice
cubic drying chammber with a loading dooor (CHRIST T
LyoCuube) (doub ble-chamber system).
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Multi-chamber mode e: In the cas

se of an Eps silon 2-90/990 freeze-drryer, the
button "MMulti-Chambber Mode" (v v) is used to
o preselect the chambe er(s) that is
(are) to be used for tthe process
s.

ol" - "Options" - "Multi-Cham
mber Mode"
The follow
wing optionss are availa
able (a dark blue framee around one of the
buttons in
ndicates the
e current se
etting):
Chamberr 1: Only cchamber 1 will

w be used d for the dryying process
s
(the icce condenseer and the shelves
s in cchamber 2 will
w
not be e used and chamber 2 will not be eevacuated)).
Chamberr 2: Only cchamber 2 will

w be used d for the dryying process
s
(the icce condenseer and the shelves
s in cchamber 1 will
w
not be e used and chamber 1 will not be eevacuated)).
Chamberr 1+2: Both cchambers will

w be used for the dryiing process
s
(with iidentical conditions in both
b chambbers).
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Tools: De epending o n the type of

o freeze-dryer and its eequipment and
features, clicking the
e button "To ers differentt additional process
ools" (4) offe
control functions.

ol" - "Tools"
Pressure increase te est: In the caase of doubble-chambeer systems or o if

"Process B" is applieed, a pressu ure increasee test can bbe performeed in the
"Manual" mode as w well as in the
e "Program"" mode duriing the dryin ng phases
"Main Dryying" and "SSecondary Drying"
D in order to deteermine the end
e of the
drying pro
ocess. The "pressure increase tes st" makes u se of the fa
act that the
pressure inside the hhermetically y sealed dryying chambeer will rise if the
product still released
d water in thhe form of vapour.

ol" - "Tools" - "Pressure
" Incrrease Test"
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For the te est, the interrmediate va alve betwee en the dryingg chamber and ice
condense er chamber and in a system
s h vacuum coontrol based on a
with
controlled d gas infloww (gas injecttion) also the injectionn line are closed for a
defined time ("Duratiion pressure increase test" t (i1)). Iff, during this
s time, the
pressure increase (d delta P) rem mains below a user-defiined threshold value
("Max. pre essure incre ease" (i2)), the drying process
p willl be conside ered
complete at the curre ent shelf tem a chambeer vacuum. In the
mperature and
case of a higher she elf temperatu ure and/or lower presssure, the pro oduct may
still releas
se water.
After the selection off the "Press sure increas se test" optioon (i), the teest can be
paramete erised and sstarted. The e values "Du uration presssure increa ase test"
(i1) and "MMax. pressu ure increase e" (i2) can be changed by clicking and with
the aid off the displayyed numeric cal keypad.
Parameter No. Value range
Duration of the pressure increase test i1 1 999 s
Maximum permissible
p pre
essure i2 1 500%
increase
The test starts

s immeediately wheen the button "Start preessure incre ease test"
(i3) is click
ked. When the valves have been closed autoomatically, the t test
time that has elapse d so far, the e start vacuum, and thee current va acuum in
the drying g chamber a ed under the button (i3)). Once the valves are
are displaye
automatic cally reopen
ned after the
e test time, the test ressult will be displayed
d
as a message in a po op-up window.

ol" - "Tools" - "Pressure
" Incrrease Test" rresult messag
ge
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CHRIST weighing
w syystem: The functions of the optionnal CHRIST weighing
system CWS-40
C he residual pproduct moisture have
for tthe determiination of th
not been implemente ed in the SC
CADA softw ware LPCpluss for the "Maanual"
mode yet. However, it can be us sed via the operating ppanel of thee LSCplus
control sy
ystem.

ol" - "Tools" - "Christ
" Weighiing System"
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2.2 M
Manual freeze-drying
g
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2.2 M
Manual frreeze-dry
ying
The "Man nual" mode is mainly us sed for the developmeent and optim misation of
processes. It can be preselected in the win ndow "Proceess Control" of the
LPCplus usser interfacee by way off the "Manual" button (aa). In the sttandard
setting, th
his mode ca an only be accessed
a by
y users of thhe user leve el
"Maintena ance" or higgher (this ca
an be config
gured by ann administra ator).
Fig. 37 P
Process Contro
ol - Manual mode
In the "Ma anual" mod e, the proce ess parame eters for thee individual freeze-
f
drying phases "Freezzing", "Warrm Up" ( = frreezing withh simultaneous warm-
up of the vacuum pu ump), "Main Drying", an nd "Second ary Drying" can be
accessed d via the butttons underr "Set Values Process P Phase" (I) (IV).

Values ca an be chang ged by click king and witth the aid off the display yed
numerical keypad. T Then, presellect the proc cess phasee that is to be b
executed by clicking one of the buttons (aI) (aIV).
After the freeze-drye
f er has been switched to o the "Run" status by way w of the
toolbar buutton "Run" , the contro ol system ad djust the sheelf tempera ature and
the chamber vacuum m directly to o the values that were sset for this phase.
p It
does not generate an ny set value e ramps. When the sett values are e reached,
the shelf temperature e and cham mber vacuum m are kept cconstant.
If the section time fo r a phase is s set to "" (infinite), thhe section will
w continue e
without an ny time limi t until the user selects another proocess phas se or
switches the unit to ""Standby" by b way of the "Standbyy" button on the
toolbar. Iff, however, a fixed section time is set, the sysstem will be e
automatic cally switcheed to the ne ext phase in n the case oof the phase es
"Freezing g" and "Main n Drying" on nce the time e has elapssed. In the case
c of the
"Warm Up" phase, th he system will
w switch to o the next pphase only after
a the
user has confirmed a message indicating the end of thhe section. This
enables the user to p place any externally
e ozen produccts into the prepared
fro
freeze-dry yer. A pop-uup window with a safetty inquiry iss also displa ayed in the
case of thhe "Seconda ary Drying" phase after the time hhas elapsed d. The unit
will not be
e switched tto "Standby y" unless this inquiry is confirmed by the
user. Thiss prevents tthe ice cond denser from m defrosting and the pro oduct from
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being rem
moistened in
n a situation
n when the freeze-dryeer is switche
ed off
unnoticed
d.
Even withh a fixed secction time, the

t process s run can bee aborted att any time
by clicking the "Stan dby" buttonn on the toolbar and byy confirming g the
subseque ent safety in
nquiry. As a result, the freeze-dryeer will be sw
witched to
"Standby".
NO
OTE
Apart fromm a phase cchange, it is s also possiible to channge the set values
v of
the currennt phase du uring a runn ning process s. As a resuult, the shelff
temperatu ure and cha amber vacuum will be immediatelyy adjusted to t the new
set values s.
The individual freeze e-drying pha ases and thhe associateed paramete ers are
explainedd in detail in
n the corresponding cha apters in chhapter 2.3 -
"Program m/recipe-co ontrolled frreeze-drying ".
If a manual interventtion should become ne ecessary duuring a program-
controlled
d process ru un (i.e. in th
he "Run" staatus), it is poossible to switch over
to the "Maanual" mod e. In doing so, the currrent set valuues will be takent over
to the "Maanual" mod e by the pro ogram. Afteer the interveention (e.g.. a
modificatiion of the cuurrent freezze-drying prrogram durinng the proc cess test
phase), itt is possible
e to switch back
b to the "Program"
" m
mode within n the
current prrocess phasse while sta ating the point of time w when the prrogram run
is resumeed. Operatin ng mode ch hanges as well
w as channges of the set s values
will be en
ntered into thhe process event list to ogether withh a time sta amp and
informatioon concerni ng the userr.
If the section time off the "Secon ndary Drying g" phase is set to "", the freeze-
dryer mus st be switchhed to "Stan ndby" manually at the eend of the drying
d
process by
b clicking t he "Standby" button on n the toolbaar. Howeverr, if a fixed
section tim
me is set foor the "Seco ondary Dryinng" phase, a correspon nding
message will be disp played afterr this time. Following
F thhe confirmattion of this
message, the freeze e-dryer will be
b switched d manually tto "Standby y".
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3 Program//recipe-con
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2.3 P
Program/recipe-controlled
d freeze--drying
For produ uction appliccations, the
e "Program" mode offerrs the opportunity to
eeze-drying process run in an auto
let the fre omated mannner and un nder
reproduciible conditio
ons.
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2.3.1 C
Creating/m
modifying a freeze-d
drying program/recipe
In order to
o create or modify a fre
eeze-drying
g program/reecipe, open
n the
window "U User Prograam/Recipe " via the button of the ssame namee (I) on the
toolbar.
If the free
eze-dryer is the "Progra
am" mode, the currentlly preselectted or
active proogram/recippe can be op pened and copied by w
way of "Savve As", but
it cannot be modified d or deleted
d.
NO
OTE
Fig. 38 Co
omparison of th
the programs/r
/recipes on the
e PC and in thhe control system
First, the programs/rrecipes that are stored on the SCA ADA PC are e
compared d (synchron
nised) with the
t program ms/recipes oof the LSCplus control
system off the conne cted freezee-dryer. The 32 storagee locations are
a
compared d (synchron
nised) one after
a the other. Four diffferent situa
ations can
be distingguished:
1. The program/rec ipe data in a program location

l aree identical on
o the
SCADDA PC and iin the control system.
No us
ser activity iss required.
2. The program locaation is occupied only on

o the SCA ADA PC bec cause the
progra
am/recipe h
has been de eleted on the control paanel of the control
c
system
m.
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A synchronisation
n window opens:
Fig. 39 A progra
am does not exist in the con
ntrol system
By clic
cking the buutton "" (bb) under the e diagram, tthe programm/recipe
can bee copied intto the corresponding program locaation in the control
systemm (upload) sso that it ca
an also be edited
e and eexecuted froom the
contro
ol panel of t he control system.
s he "Cancel"" button is clicked, this
If th
prograam location will remain n empty.
3. The program loca ation is only

y occupied in
i the contro
rol system because
b
the prrogram/recip
pe has been created via the contrrol panel of the control
systemm.
A synchronisationn window opens:
Fig. 40 A progra
am does not exist on the SC
CADA PC
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By cliccking the bu
utton "" (aa) under thee diagram, tthe program m/recipe
can be e copied intto the corresponding program locaation on the e SCADA
PC (download). I f the "Canc s clicked, thhis program location
cel" button is
will remain emptyy on the PC C.
4. The program/rec ipe data of a program location difffer between

n the
SCADDA PC and tthe control system bec cause the prrogram/reciipe has
been modified via
a the contro
ol panel of the control ssystem.
n window opens:
A synchronisation
Fig. 41 The prog

gram data are
e not identical
By clic
cking the bu a), the program/recipe data on the
utton "" (a e SCADA
eplaced with the ones from the co
PC will be overw ritten and re ontrol
systemm. By clickin
ng the butto
on "" (b), the program m/recipe data of the
contro
ol system wwill be overw
written and replaced
r witth the ones from the
SCAD DA PC. If thee "Cancel" button is clicked, the pprogram/rec
cipe data onn
the PCC and in the
e control system will bee maintaineed although they differ
from each
e other.
After the comparison n (synchronisation), the

e functions "New" (crea ation of a
new user program/re ecipe by moodification of
o a program m template),, "Open"
(modificattion of an e
existing userr program/reecipe or creeation of a new
n user
program/rrecipe by m modification of an alreaddy existing one), and "Delete"
are availa
able in the ""User Progrram/Recipe"" window.
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Fig. 42 - "U
User Program/R
Recipe" - "New
w"
A new fre
eeze-drying program/re ecipe will alw
ways be creeated based
d on a
template. The templa
ate can eithher be one ofo the CHRIIST programm/recipe
templates
s in the LPC
Cplus softwarre or an alre
eady existinng user
program/rrecipe.
New: Clic cking the "N

New" button (1) opens a list of proggram/recipe e
templates s. When a p program is selected,
s it is loaded innto the program editor.
It receives the numb ber of the ne ext free proggram locatioon in the co ontrol
system an nd the statuus "Program m changed", since it is not consiste ent with
the (non-eexistent) daata in the prrogram loca ation. If all oof the 32 pro
ogram
locations are occupie ed, a corres sponding message willl be displayed after
the selecttion of the te
emplate. Th he user can n then eitherr cancel the e process
or select a program llocation tha at will be oveerwritten.
The progrram/recipe can then be e modified anda stored iin this locattion by
clicking "S
Save" (3). FFirst, it will be
b stored on n the SCAD DA PC and thent it will
be copied d immediate ely into the correspond
c ing program m location of
o the
control syystem.
Open: When the "Op pen" button

n (2) is clicke
ed, a list is opened thaat shows
the prograam location ns in which user progra ams/recipess are stored. This list
includes the
t location ns that are occupied
o bo
oth in the coontrol system
m and on
the SCAD DA PC as w well as the program
p loca
ations that aare occupieed only on
one side. If a program i selected that containns different program
m location is
data on th t synchroonisation window (see
he PC and iin the contrrol system, the
above) will be opene ed again. Thhen, the proogram/recippe that is stoored in this
program location
l is lo
oaded into the program m editor. If tthe program
m location
is occupieed on the PPC and in the control sy ystem (also in the case e of non-
identical program
p da
ata), the sys
stem will alwways load thhe program//recipe
from the control
c systtem.
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After the subsequentt modificatio on of the prrogram/recippe, it can th hen be

saved to the
t original program lo ocation by clicking "Savve" (3) or it can be
saved as a new prog gram/recipe e to the nextt free prograam location n by
clicking "S
Save As" (4 4). In both cases,
c it will first be sto red on the SCADA
S
PC and itt will then be
e copied immmediately into the corrresponding program
location of
o the contro ol system.
Delete: Clicking
C the "Delete" buutton (5) ope
ens a list off program loocations in
which use er programss/recipes arre stored. This list incluudes the loc
cations that
are occuppied both in the controll system and on the SC CADA PC as a well as
the prograam locationns that are occupied
o nly on one sside. When a program
on
location is
s selected, the programm/recipe thaat is stored therein will be deleted
from the SCADA
S PC
C as well as from the co ontrol system m without any
a further
inquiry.
After "New
w" or "Openn" has beenn clicked and after a prrogram/recip
pe
dy existing program/recipe has beeen selected, its
template or an alread
programmmed set valuue course is
s displayed in graphicaal form.
(a) Program nu
umber ( = program
p loca
ation)
(b) Program na
ame
(c) Source of tthe program
m/recipe:
New: Freeze-ddrying program/recipe template.
Control Uniit: Data of a program location in tthe control
system.
Hard Disk: Data of a program location on the SCADA A PC.
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(d) Change sta

atus of the program/rec
p cipe:
<empty>: The proggram/recipe e is already stored in th
his
form in a program lo ocation.
Program The proggram that is s displayed has been
changed: created based on a template oor it is an
already existing pro ogram that hhas been
modifiedd. It must bee saved in oorder to be
able to execute
e it.
(e) Programme ed total timee of the program/recipee and its
calculated e
end (not inc cluding any automatic ssection
ues are not reached).
extensions , e.g. if certain set valu
(f) Programme ed runtimess of the freeze-drying pphases
"Freezing", "Main Drying", and "SSecondary D Drying".
Fig. 43 "U
User Program//Recipe" gra
aphical represe
entation of thee set value cou
urse of a
program/rec cipe
A freeze-drying prog gram/recipe consists off several proogram sectiions with
different durations.
d E
Every progra am section is defined bby a set of
paramete ers. Additionnal general set values define
d the ggeneral free
eze-dryer
settings as
a well as ad dditional functions thatt can be perrformed durring the
process run.
r 32 custtomised use er programss/recipes, eaach one witth up to 64
sections, can be crea ated and managed with the aid off the LPCpluss software.
Section 1 of a freeze e-drying proogram includ des the starrt parameteers and is
reserved for loading (precooling g) the freezee-dryer. Thee sections 2 64 can
be used for
f program ming specia al set value
e curves thaat are optimaally
adapted tot the produ uct in view of
o the shelf temperaturere and cham mber
vacuum during
d hree freeze-drying pha
the th ases "Freeziing", "Main Drying",
and "Seco ondary Dryiing".
In genera al, a programm section iss defined byy the followi ng parametter set (not
all of the parameterss that are lis evant for evvery freeze-drying
sted are rele
phase):
Proceess phase to o which the section is assigned

a
Sectioon time
Set vaalue of the sshelf tempe erature at the end of thee section
Set vaalue of the cchamber va acuum at the e end of thee section
Safetyy pressure
(see chapter
c 2.3..2.3 - "Main n drying (suublimation))")
Delta--Tshelf (differrence betwe een the set and actual shelf tempe erature)
(see chapter
c 2.3..2.3 - "Main n drying (suublimation))")
Delta--Tproduct (diffeerence betw ween the prroduct and sshelf tempe erature)
(s. cha
apter 2.3.2..2 - "Freezin ng" und cha apter 2.3.2. 3 - "Main drying
d
(subliimation)")
LyoCo ontrol-RX (e electrical resistance of the productt)
(s. cha
apter 2.3.2..2 - "Freezin ng" und cha apter 2.3.2. 3 - "Main drying
d
(subliimation)")
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Based on n the section n times and d the predefined, discreete set valuees
concerninng the shelff temperaturre and cham mber vacuuum at the en nd of each
section, thhe control ssystem calc culates the continuous
c sset value cu
urves for
the course of the sett values ove er time.
For everyy single prog gram sectio on, the systeem calculate
tes a ramp for
f the
temporal course of th he temperature and va acuum set vvalues. This s ramp
starts with
h the set vaalue of the previous
p sec
ction and ennds with thee set value
of the currrent sectionn (this mean ns that the set
s values tthat are deffined in a
section pa arameter se et will not be
e reached until
u the endd of the sec
ction):
Fig. 44 Thhe temporal coourse of the shelf temperatuure and vacuuum set values within a
section is ca
alculated as a linear functio
on ("ramp") between the sett value of the previous
p
section andd the set value
e of the current section.
By using several pro ogram sectio ons for the definition
d off a freeze-drying
phase, sp pecial set vaalue curves s can be cre eated basedd on several linear
curve sec ctions. As a result, it is possible to create freeezing and drying
courses that are optiimally adap pted to the product
p in quuestion. The high
number ofo possible p program sec ctions enabbles the veryy fine mode elling of the
set value curves.
The contrrol system o of the freeze e-dryer controls the shhelf tempera ature and
chamber vacuum du uring the pro ocess run inn accordancce with the calculated
c
set value curves. In a addition, it registers
r the
e actual vallues and mo onitors
complianc ce with the limit values s that are deefined by thhe other four section
paramete ers. If an acttual value iss above or below
b a lim it value, the
e control
system isssues an ala arm and performs a fixed routine ((e.g. extens sion of a
section if certain swittching criteria are not met,
m deactivvation of the e shelf
t product is at risk off thawing; see also the chapters th
heater if the hat are
stated in connection with the ind dividual parrameters).
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Table: Th
he section-sspecific para
ameters aree defined byy way of a table.
t The
columns of e symbolise the program/recipe seections, while the lines
o this table
are forme
ed by the paarameters. In e the paraameters, the table
I order to edit
must be opened
o in a separate window
w by clicking
c the "Table" buttton (9).
Fig. 45 - "U
User Program/R
Recipe" "Table"
The arrow w buttons (iiii) can be us
sed to browwse the secttions (= colu umns).
Click "Insert" (i) to in sert a new section afteer the selectted section (marked in
he process phase to which
blue). If th w the new section iss to be assigned is nott
already clearly define ed by the position of in
nsertion (e.gg. if a sectio
on is
inserted between
b two he possible phases will be
o phases), a list with th
displayed d for selectio g "Delete" (iii) deletes thhe selected section
on. Clicking
without an ny further innquiry. The parameters s can be chhanged by clicking
c the
correspon nding table line and witth the aid of the numerrical keypad d that will
be display yed.
The exam mple of a freeeze-drying program/re ecipe that iss shown below
demonstrrates the rellationship between
b the
e discrete seet values co oncerning
the shelf temperature e and vacuum in the ta able and thee resulting calculated,
c
continuou us set valuee curves with their temp perature annd vacuum ramps.
r
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Fig. 46 Rellationship be
etween the dis
screte set va lues in the ta
able and the resulting
r calcculated, contiinuous set
value curvess
Set valuees: Apart froom the secttion-specificc parameterrs, program ms/recipes

also require addition al, general set values. The additioonal set values define
general frreeze-dryerr settings ass well as additional fun ctions that can be
executed during the process run n.
In order to et values, click the buttoon "Set Values" (10)
o edit the a dditional se
under thee program/re ecipe diagraam.
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Fig. 47 "U
User Program//Recipe" "Se
et Values"
Set valuees: After the

e button "Se
et Values" (a
a) has beenn clicked, the warm-up
time of the vacuum p pump can be
b specified.
Fig. 48 "U
User Program//Recipe" "Se
et Values" "S
Set Values"
In order to o increase tthe service life of the vacuum
v pum
mp, it is imp
portant to
not load it with conde ensable gas h reachedd its operating
ses until it has
temperatu ure. This is why it is recommended to allow thhe pump to o warm up.
If this is th
he case, thee pump will be started already durring the "Fre eezing"
phase wh hen the presssure contro ol valve in the suction lline towards
s the
chamber is still close ed.
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The "Warrm-up time vvacuum pump" value (i) ( can be chhanged by clicking
c
t aid of a numerical keypad that will be dis played. It should be att
and with the
least 15 minutes
m long e pump will be calculate
g. The startt time of the ed
automaticcally so thatt the warm-up time end ds preciselyy at the starrt of the
main drying phase.
Parameter No. Value rangee
Warm-up tim
me i 5 min 59 m
min
The "Man nual" mode offers the special

s proccess phase "Warm Up"" in the
"Process Control" wiindow. The only differe ence betweeen this phas se and the
"Freezingg" phase is tthat the vac cuum pump is running while the pressure
control va
alve in the ssuction line towards the
e chamber iis still close
ed. The
NO
OTE paramete ers of the "W Warm Up" phase
p can be accessedd via the ass sociated
button (II)). It is prese
elected by way
w of the button
b (aII). D
During a running
"Freezingg" phase, it is always possible to switch
s over tto "Warm Up",
U
thereby starting
s the vvacuum pummp.
Aeration, stoppering , storage: Iff the freeze--dryer is eqquipped withh an

automaticc aeration vvalve and a hydraulic shelf movem ment system m, the
function "Aeration, SStoppering, Storage" ca an be used to aerate th he chamberr
at the end
d of the freeeze-drying process
p unttil a defined partial vacuum is
reached, to seal the product via als automatically underr this vacuum m (option),
and to ae
erate the cha amber afterrwards up to o atmospheeric pressurre. Then,
the produuct will be sttored on the
e shelves att a defined ttemperature until the
user switcches the freeeze-dryer manually
m to "Standby"..
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For stopppering, all off the shelve

es that are used
u must bbe loaded completely
and with identical pro oduct vials in order to prevent
p thee shelves an
nd guide
rods as well
w as the vvials from be eing damag ged or brokeen.
If the she
elves are onnly partially loaded,
l addditional emppty vials with
h inserted
CAUT
TION stoppers, or spacerss (of the sam me height), must be poositioned on n the
shelves inn order to e
ensure a uniiform distribbution of thee force. Suittable
spacers are
a available e upon requ uest.
The "Aera
ation, (Stop
ppering,) Stoorage" optio
on can be aactivated and
paramete
erised by cli cking the button "Aeration, Stoppeering, Stora
age" (b).
Fig. 49 - "U
User Program/R
Recipe" "Set Values" "A
Aeration, Stopppering, Storag
ge"
By clickin
ng the button
n (i) repeateedly, one off the followi ng four variiants can
be selecteed (the labe
elling of the button indicates the cuurrent variaant):
Disabled: Theree will be no automatic

a aeration,
a (sttoppering,) and
storag
ge.
Aeration, Partia
al aeration (tto the desired partial va
vacuum under which
Storage: the prroduct is to be stored) and
a subseqquent storag ge
(undeer this vacuuum and with h the definedd shelf temperature).
Stopperin
ng, Stopppering (unde er the drying
g vacuum, ffollowed by
Storage: aeratioon to atmosspheric presssure) and ssubsequent storage
(with tthe defined shelf tempeerature).
Aeration, Partiaal aeration (tto the desired partial va

vacuum under which
Stopperin
ng, the prroduct vials are to be sealed (backkfilling)), sto
oppering
Storage: (follow
wed by aera ation to atmospheric prressure and d
subse equent storaage (with the defined s helf temperrature).
The valuees of the pa arameters (ii) (v) that are descriibed below can be
changed by clicking and with the aid of the numerical keypad tha at will be
displayed
d. Dependin election, nott all of the pparameters are
ng on the se
available at all timess.
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1. Partia
al aeration u
up to the desired partial vacuum:
While the
e ice conden nser is coole
ed further and
a the shellf temperatu ure is
maintaine
ed at the seet value of th
he end of thhe last dryinng section, the
t
chamber is aerated tto the press sure that is specified byy way of "Aeration"
(ii).
Stopperinng must be performed at a chamber pressuree below 900 0 mbar in

order to prevent
p the stoppers fro
om being pushed out oof the vials at
a low
ambient pressure.
p
NO
OTE
2. Stopppering followwed by aera ation to atmo ospheric preessure (opttion):

While the
e ice conden nser is cooleed further and
a the shellf temperatu ure is
maintaineed at the seet value of th
he end of th he last dryinng section, the
t shelves
are moveed together, thereby pre essing the LyoL stopperrs into the vials.
v The
stoppering pressure will be maintained for the time thaat is specifie ed by way
of "Stoppering" (iv).
The subsequent aera ation of the chamber to o atmospheeric pressure is
performedd in two ste e chamber is aerated up
eps. In the fiirst step, the u to the
pressure that is speccified by waay of "Aeration after stooppering" (iii). Then,
the shelve
es are move ed apart baack to the drrying positioon. Then, th he aeration
continuess up to atmo ospheric preessure. This s method reeduces the risk of
stoppers getting stucck to the shelves above e them (whiich may hap ppen if the
shelves are
a not move ed apart unntil after the complete aaeration to
atmosphe eric pressurre) and it alsso prevents s the Lyo stooppers from
m being
pushed out of the via als (which may
m happen n if the shelvves are movved apart
without an
ny prior aerration).
3. Storagge at a definned shelf te

emperature::
The shelff temperaturre is now brrought to the storage teemperaturee that is
specified by way of ""Storage" (vv). This temperature wiill be mainta
ained
constant until the fre s manually switched too "Standby" for
eeze-dryer is
removing the producct.
In the cas
se of the "AAeration, Sto orage" varia
ant, the prodduct is store ed under
the presssure that is sspecified byy way of "Aeeration" (ii). In this case
e, the
chamber must be ae erated manu ually to atmospheric prressure befo ore it can
be opene ed (see chap pter 2.4 - "A
Aeration").
NO
OTE
Partial vacu
uum for stoppe
ering ii 100 mbar 1000 mbar
Partial vacuuum after the ffirst step of the

e iii 100 mbar 1000 mbar
final aeratio
on
Stoppering time iv 1 sec 9999 sec
Storage tem
mperature v -99.9C +999.9C
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The settin
ng "Automa atic" (see be
elow) of the aeration meedia preselection
enables the backfillin oduct vials with inert gaas and the
ng of the pro
subseque ent aeration
n of the cham mospheric ppressure with air.
mber to atm
CHRIST weighing
w syystem: If the
e freeze-dry
yer is equippped with a CHRIST
C
weighing system CW WS-40, the product
p can
n be weigheed automatic cally at
regular in
ntervals duriing the freeze-drying phases. Thiss enables an online
determinaation of the residual mo oisture conttent.
Fig. 50 - "U
User Program/R
Recipe" "Set Values" "C
Christ Weighing
ng System"
By clickin
ng the button
n (i) repeateedly, one off the three ffollowing va
ariants can
be selecteed (the labe
elling of the button indicates the cuurrent variaant):
Disabled: There
e will be no automatic
a weighing
w of the productt.
During main The p b weighed automaticaally at regular

product will be
drying: interva
als during all
a of the "Main Drying" sections.
During main The pproduct will be

b weighed automaticaally at regular
and secon- interva
als during all
a of the "Main Drying" and
dary dryin
ng: "Secoondary Dryin ng" sections
s.
The weighing processses are solely intendeed for the accquisition off
measuremment valuess during the e developmeent of proceesses. They y will not be
e
used any further by tthe control system.
s The
e "Weighingg Interval" (ii)
( can be
changed by clicking and with the aid of a numerical keeypad that will
w be
displayed
d.
Weighing in
nterval ii 1 sec 60 ssec
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Aeration medium
m preeselection: If the freeze
e-dryer is eqquipped witth an
automatic c aeration vvalve and auutomatic valves for meddia selectioon, the
button "Preselection Aeration" (d)
( can be usedu to presselect the medium
m that
is to be used for all o
of the aeratiion mediumm requests aas of the sta
art of the
main drying phase. ((The aeratio on valve is permanently
p y open during
"Precoolinng" and "Frreezing". Thhese section ns always uuse air.)
Fig. 51 - "U
User Program/R
Recipe" "Set Values" "P
Preselection Aeeration"
If the vacuum contro ol system off the freeze--dryer uses a controlled gas
inflow (gaas injection)), the preselected medium will be used for this purpose.
eze-dryer is equipped with
If the free w the "Ae eration, Stopppering, Sto
orage"
option, the preselectted medium m will be use
ed for the aeeration up to
o
stoppering (backfillinng) as well as
a for the fin
nal aerationn up to atmo
ospheric
pressure.
The followwing media preselectio on settings are
a possiblee (a dark blu ue frame
around on ne of the bu
uttons indicaates the currrent settingg):
Air: Prese
elects the media connection "Air".
Inert gas: elects the media connection "Inert Gas".

Prese
Automatic
c: Autom matic media a connectionn preselectioon depending on
the chhamber pres ssure and stoppering
s sstate of the
produ ct vials:
Ch amber pres ssure 950 mbar or prroduct vials
alre
eady sealed on, stopperinng, storage
d by aeratio e:
Preeselection ofo the mediaa connectionn "Air".
Ch amber pres ssure < 950 mbar and pproduct vials
nott yet sealedd by aerationn, stopperinng, storage:
Preeselection ofo the mediaa connectionn "Inert Gas s".
As a rresult, durin
ng automatic c aeration, sstoppering, and
storagge, backfillin
ng can be performed
p aautomatically y with
inert g
gas and the e subsequen nt aeration oof the cham mber up
to atm
mospheric pressure with air.
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Gas injecction: If the ffreeze-drye

er is equippe
ed with a prroportional gas
g
injection valve,
v the b
button "Gas Injection" (e) can be uused to presselect the
vacuum control
c methhod that is to
t be used.
Fig. 52 - "U
User Program/R
Recipe" "Set Values" "G
Gas Injection"
The follow
sible (a dark
ne of the
buttons in
ndicates the
e current se
etting):
Off: The g as injectionn is deactiva

ated. Vacuuum control is
s ensured
solelyy by openingg and closinng the presssure controll valve in
the suuction line of
o the vacuum pump.
Standard: Vacuu um control is ensured by b a combinnation of ev vacuation

and ga as injection
n. If the actuual vacuum is worse than the
set vaalue, the sys
stem will be e evacuatedd by opening g the
pressu ure control valve. If it is
s better tha n the set va
alue, gas
will be
e injected byy opening the proportioonal valve.
Continuou
us: Vacuuum control is performed d with the ppressure control valve
being continuous sly open andd solely by vvarying the injection
flow w
with the aid of the propo
ortional valvve.
Name: Affter the buttton "Name" (8) has beeen clicked, tthe program
m/recipe
can be re
enamed by w way of the displayed
d alphanumeriical keypad.
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History: The
T button "History" (1
11) can be used
u to tracce back prog
gram/
recipe changes that are automa
atically regis
stered with a time stam
mp and
user ID.
Fig. 53 "U
User Program//Recipe" "Hiistory"
In addition, the user can enter comments
c concerning
c tthe program
m changes
by clicking the button ment will be aautomatically
n "Note" (i). The comm
preceded by a time sstamp, userr ID, and the
e word "Notte".
Printing the
t progra am/recipe data:
d Apart from
f the acctual print fu
unction
concerninng the progrram/recipe data, the bu utton "Print"" (6) also offfers a
corresponnding print ppreview as well as the output in P PDF under "Preview" -
"Save As".
After the selection off "Print" the desired sco
ope of the pprintout mus st be
defined.
Fig. 54 "U
User Program//Recipe" "Prrint" definition of the print sscope
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Click the buttons (i) (iv) in ord

der to selec
ct the individdual options
s (dark
blue fram
me) or to desselect them:
Prograam diagramm
Table
Additional set vallues
Prograam history
Fig. 55 "U
User Program//Recipe" "Prrint"
wing section
The follow ns provide a detailed explanation
e of the individual
freeze-dryying phasess as well as
s of the para
ameters of tthe associa ated
sections.
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Pos: 39 /200 Christ/400 Software-Bedienungsanleitungen (STANDARDMODULE)/LPCplus Rev 1.0/060 Betrieb/0600-0060-0020 Gefriertrocknungsphasen im Detail - - - - - - - - - - - - - - - - - - - - - - - - - @ 13\mod_1346910116328_68.docxx @ 71770 @ 3 @ 1
2.3.2 F
Freeze-dry
ying phase
es in detaiil
Pos: 41 /200 Christ/400 Software-Bedienungsanleitungen (STANDARDMODULE)/LPCplus Rev 1.0/060 Betrieb/0600-0060-0020-0010 Beladen @ 13\mod_1346910116844_68.docx @ 71778 @ 4 @ 1
2.3.2.1 Precooling
g
The freezze-drying prrocess starts with a "Prrecooling" ssection. In th his section,
the shelvees are brouught to a spe ecific tempeerature (loadding tempe erature) thatt
must be defined
d in th
he recipe de efinition. The freeze-drryer can be loaded
when thiss temperatu re is reache ed. In orderr to ensure tthat there is
s sufficient
time for th
his process , this first se
ection of thee program/rrecipe does s not have
a specific
c section tim
me (unlike all the other sections). I nstead, the e
program/rrecipe mustt be switche ed manually y to the seco
cond section n when the
precooling (loading) phase is co ompleted.
The followwing screen nshot shows s the param meters that m
must be deffined for
the "Precooling" (loaading) sectio on:
Fig. 56 Pa
arameters of tthe "Precooling" section (section 1)
The set shelf temperrature value e (2) for the precooling phase is no ormally
(i.e. when
n loading noon-frozen prroducts into o the freeze--dryer) set tot the
ambient temperature
t e. If the prod
duct is prefrrozen exterrnally, it mus st be set to
the produuct temperatture in ordeer to prevent the producct from thaw wing on the
shelves.
At the begginning of thhe "Precooling" section n, the shelvves are brou ught to the
selected precooling
p ttemperaturee (2) as quickly as posssible (i.e. without
w
generatinng a temperarature ramp) and then keptk constaantly at this
temperatu ure. Then, tthe product can be plac ced on the sshelves.
The preco ooling (load
ding) temperature is als so the start value for thhe
calculatio
on of the sheelf temperature in the first
f "Freezinng" section. The start
value for the vacuum m ramp is thhe atmosphe eric pressurre.
Shelf tempe
erature 2 -99.9C +999.9C
There is no
n "Precoolling" section n in the "Ma
anual" modee. In this moode, the
freeze-dry
yer is loade
ed with unfroozen products in the "S Standby" status,
while the loading of tthe freeze-d
dryer with prefrozen prroducts is pe
erformed
during a running
r "Fre
eezing" pha ase and withh a shelf tem
mperature that
t is
NO
OTE selected accordingly
a y.
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2.3.2.2 Freezing
When the e product haas be loade ed into the drying chammber, the chamber has
been clos sed, and thee program/rrecipe has been
b switchhed to the next section
by the user (see cha apter 2.3.3 - "Executing a freeze--drying
program//recipe "), tthe actual frreeze-drying g process bbegins in se ection 2
when the product is ffrozen on th he shelves. From now on, the process will
run fully automaticall
a ly, controlle
ed by a proggram/recipee, until it end
ds.
The followwing screen nshot shows s the param
meters that mmust be deffined for a
"Freezing g" section:
Fig. 57 Pa
arameters of a "Freezing" section
s
During the section timme (1), the shelf tempeerature is deecreased linnearly from
the set "S
Shelf" value of the prevvious section to the sett "Shelf" value of the
current se
ection (2) baased on thee set value ramp
r that hhas been caalculated by
the contro
ol system.
The comb eezing" sections with ddifferent gradients of
bination of sseveral "Fre
the shelf temperature e set value ramps enables the deffinition of sp pecial
freezing curves
c that are optimallly adapted to the prod uct.
Delta-Tshelf test: In o order to ens sure that the e actual sheelf temperatture value
is close to
o the set va alue prior to switching to the next ssection, the automatic
verificatio
on of the tem mperature difference
d between the actual and set value
at the endd of each se ection can beb activated d. To do so,, the parameter
"Delta-Tshhelf" (5) of th
he section can be used to define a maximum
permissib ble differencce.
The progrram will nott switch to the next sec ction unlesss the differen nce
between thet actual a and set valu ue at the end of this se ction is belo ow this
value. If this conditio on is not fulffilled, a corrresponding alarm will be b
generated d and the se ection will be
b extended d until it is fuulfilled. In order to
deactivate e the autom matic verificaation, set thhe parameteer "Delta-Tshelf" to
"Off".
Delta-Tprooduct test: D
Depending on
o the layer thickness oof the produ uct and
vessels, the
t product temperaturre will follow
w the shelf ttemperature e in a more
or less de
elayed man ner during the
t freezing g phase.
In order to
o ensure th at the product is comp
pletely frozeen prior to swwitching to
the "Mainn Drying" ph hase, the au
utomatic verrification of the temperrature
difference
e between tthe product and shelf ata the end off the last "F
Freezing"
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section ca an be activa ated. To do so, the parrameter "Deelta-Tproduct" (6) in this

section ca an be used to define a maximum permissiblee difference.
between thet productt and shelf temperature
t e at the endd of this sec ction is
below this s value. If th
his condition is not fulfilled, a correesponding alarm
a will
be genera ated and th e section will
w be extended until it iis fulfilled. In addition,
the autom matic verificaation can be e activated at the end oof any "Freezing"
section inn order to en nsure that the product temperature re follows th
he
programm med freezing g curve. In order to deactivate thee automatic
verificatio
on, set the p parameter "Delta-Tproduct" to "Off".
LyoControl-RX testt: In the cas se of freeze-dryers thatt are equipp ped with a
CHRIST LyoContol
L m
measureme ent system, the electriccal resistanc ce of the
c be moniitored during the proce
product can ess by way oof a sensor in the
product. This
T enable es conclusio ons concern ning the crysstallisation state of the
product too be drawn,, since the electrical
e resistance off a frozen aq queous
solution is
s usually be etween 90% % and 100% % (dependinng on the product),
whereas the
t resistan nce in the liqquid state is
s between 55% and 15% %.
In order to
o ensure th at the product is comp pletely frozeen prior to sw
witching to
the "Mainn Drying" ph hase, the au utomatic verrification of the electric
cal
resistancee of the prooduct at the end of the last "Freeziing" section n can be
activated. To do so, the parame eter "LyoControl-RX" (77) can be us sed to
define a minimum
m re
esistance (e e.g. 85%, de epending onn the produc ct).
The progrram will nott switch to the next sec ction unlesss the electriccal
resistancee of the prooduct at the end of the section is aabove this value. If this
ed, a corres
condition is not fulfille sponding alarm will be generated and the
section will
w be extend ded until the condition is fulfilled. In order to deactivate
the autommatic verifica ation, set th
he paramete er "LyoConttrol-RX" to "Off".
"
Section time
e 1 1 min 2500 h
Shelf tempe
erature 2 -99.9C +999.9C
Delta-Tshelf 5 1C 25C / off
Delta-Tproduct 6 1C 25C / off
LyoControl--RX 7 1.0% 99.00%

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2.3.2.3 Main dryin

ng (sublima
ation)
When the e product ha as been froz zen to the selected
s tem
mperature, the
t switch-
over to the "Main Dryying" phase e can be performed.
First, the chamber iss evacuated d to the sele
ected dryingg vacuum. Then,
T the
product iss provided w with the neccessary sub blimation ennergy by hea ating the
shelves, while
w it is ke
ept in the fro
ozen state due
d to the vvacuum. Th he
temperatu ure in the p roduct is deetermined based
b on thee vapour prressure
curve for ice. The ice e condense er is cooled to the lowesst possible
temperatu ure in orderr to extract and
a bind the e water vappour that is released
during thee sublimatio on.
The followwing screen nshot shows s the param
meters that mmust be deffined for a
"Main Dry ying" sectio n:
Fig. 58 - Pa
arameters of a "Main Drying
g" section
In an ana alogous man nner as for a "Freezingg" phase, th e shelf temperature is
linearly in
ncreased froom the set "Shelf"
" value of the preevious sectio on to the
set "Shelff" value of t he current section
s (2) during
d the ssection timee (1).
During a "Main Dryin ng" section, however, the chambeer vacuum is s
simultane eously and llinearly chaanged from the
t set "Vaccuum" value e of the
previous section to th he set "Vaccuum" value e of the currrent section (3) based
on the set value ram mp that has been
b calculated for thiss purpose.
The comb bination of sseveral "Maain Drying" sections
s witth different gradients
of the sheelf temperatture set valuue ramps enables the ddefinition off special
heating curves that a are optimally adapted to t the produuct.
Fig. 59 Drrying course ((example)

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Safety prressure: Si nce the tem mperature in n the producct is determmined by

the chamber vacuum m and sincee a loss of va
acuum, e.g . if the shelv ves are
heated tooo quickly, ccan cause thhe product to thaw, thee monitoring g of the
vacuum is s of utmost importance e in view of the productt safety.
In order to
o activate thhe continuo
ous vacuum m monitoringg function fo or a
section, th
he parametter "Safety pressure"
p (4
4) of this seection is use
ed to define
a maximu um permiss ible chambe er pressure
e (see the exxample and d table
below).
The contrrol system ccontinuously y compares s the currennt measured d chamber
pressure to the speccified "Safetty pressure"" during the section. Th he shelf
heater will not be acttivated untill the chamb
ber pressuree is below th he "Safety
pressure"". If the chammber presssure then ris
ses above thhe "Safety pressure",
p
an alarm will be gene erated and the shelf heeater will bee deactivateed.
Because of the heat withdrawal due to the sublimationn, the produ uct cools
down. The heater wi ll be reactivvated when the definedd "Safety prressure" is
reached again.
a In ord ctivate the continuous vvacuum monitoring
der to deac
function, set the para ameter "Saffety pressurre" to "Off".
Example (frreezing point o of the product: -5C):

It is recommmended to free eze the product to >10K bellow its freezingg point.
The recomm mend drying vvacuum can be e found on thee vapour presssure curve forr ice at the
temperature e value that iss 10K below th he freezing point. The "Safetty pressure" is s located at
the tempera ature value tha at is 5K higher.
At this dryin
ng vacuum and d if the shelve
es are heated slowly, the tem mperature in the
t product
cannot rise above a value e that is 10K below
b the freezing point. If tthe shelves arre heated too
quickly, the heater will bee switched off when a pressure is reachedd that corresponds to a
product temmperature of 5 K below the frreezing point. In this case, tthere is still a safety
s
margin of 5K before the p products starts s to thaw.
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Va
alue table (va
apour pressure curve for iice)
C mbar C mbar
m C
C mbaar C mbar
0 6.110 -20 1.030 -40

0 0.1200 -60 0.011
-1 5.620 -21 0.940

0 -41 0.1100 -61 0.009
-2 5.170 -22 0.850

0 -42
2 0.1000 -62 0.008
-3 4.760 -23 0.770

0 -43
3 0.0900 -63 0.007
-4 4.370 -24 0.700

0 -44
4 0.0800 -64 0.006
-5 4.020 F reezing pointt 0.0054
-6 3.690 0.0047
-7 3.380 0.0041
-8 3.010 0.0035
(corresponds to 10 K)
-9 2.840 0.0030
10 steps
-10 2.560 "S
Safety pressu
ure" 0.0026
-11 2.380 0.0023
(corresponds to
-12 2.170 5 steps 0.0019
5 K)
-13 1.980 0.0017
-14 1.810 0.0014
-15 1.650 S
Set vacuum va
alue 0.0012
-16 1.510 -36 0.200

0 -56
6 0.0188 -76 0.0010
-17 1.370 -37 0.180

0 -57
7 0.0166 -77
-18 1.250 -38 0.160

0 -58
8 0.0144 -78
-19 1.140 -39 0.140

0 -59
9 0.0122 -79
Delta-Tshelf test: In o
order to ens sure that the e actual sheelf temperatture value
is close to
o the set vaalue prior to switching to the next ssection, the automatic
verificatio
on of the tem
mperature difference
d between the actual and set value
at the endd of each se ection can also
a be activ vated duringg the "Main n Drying"
phase. To o do so, thee parameterr "Delta-Tsheelf" (5) of thee section ca an be used
to define a maximum m permissible difference.
between thet actual a and set valu ue at the end of this se ction is belo ow this
value. If this conditio
on is not fulffilled, a corrresponding alarm will be b
generated d and the seection will be
b extended d until it is fuulfilled. In order to
deactivate e the autommatic verificaation, set thhe parameteer "Delta-Tshelf" to
"Off".
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Delta-Tprooduct test: D
During the sublimation, the producct is maintained in the
frozen sta
ate by the vvacuum. The e temperatu ure in the prroduct is de etermined
by the chamber vacu uum in acco ordance with the vapouur pressure curve for
ice. Towaards the end d of the sub
blimation, i.e
e. after the w water has been
b
withdrawn n from the p product, the
e product temperature aapproaches s the shelf
temperatu ure.
o ensure th at the sublimation has been comppleted at the
In order to e current
shelf temperature an nd chamberr vacuum prrior to switchhing to the
"Seconda ary Drying" phase, the automatic verification
v oof the temp
perature
difference
e between tthe product and shelf at a the end off the last "M Main
Drying" seection can b be activatedd. To do so, the param meter "Delta--Tproduct" (6)
can be ussed to defin e a maximu um permissible differennce.
between the
t productt and shelf temperature
t e at the endd of the secttion is
below thiss value. If th
his condition is not fulfilled, a correesponding alarm
a will
be genera ated and th e section will
w be extended until it iis fulfilled. In order to
deactivatee the autom matic verifica
ation, set th
he parameteer "Delta-Tproduct
p " to
"Off".
LyoControl-RX testt: During a "Main " Dryin

ng" section, the LyoCon ntrol-RX
measurem ment system m can be us sed to preve ent the prodduct from th
hawing if
the freezee-dryer is eqquipped witth such a sy ystem (for innformation concerning
its mode of operation n please reffer to chapter 2.3.2.2 - "Freezing"").
In order to
o activate thhe continuo ous monitoring functionn for a sectioon, the
paramete er "LyoContrrol-RX" (7) of this sectiion is used to define a minimum
resistancee (e.g. 85% %, depending g on the pro
oduct).
The contrrol system ccontinuously y compares s the currennt measured d electrical
resistancee of the prooduct to the specified minimum
m ressistance during the
section. When
W it dete e electrical resistance ffalls below this
ects that the
minimum resistance,, an alarm will w be gene erated and tthe shelf heeater will be
deactivateed. Becausse of the hea at withdraw
wal due to thhe sublimation, the
product cools
c down. The heaterr will be reactivated whhen the defined
minimum resistance is reached again. In order to deacctivate the continuous
c
resistancee monitoring g function, set the paraameter "LyooControl-RX X" to "Off".
Section time
e 1 1 min 2500 h
Shelf tempe
erature 2 -99.9C +999.9C
Chamber va
acuum 3 0.0010 mbarr 1000 mba
ar
Safety pres
ssure 4 0.0010 mbarr 1000 mba
ar / off
Delta-Tshelf 5 1C 25C / off
Delta-Tproduct 6 1C 25C / off
LyoControl--RX 7 1.0% 99.00%
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Apart from
m the Delta--Tproduct testt, it is also possible
p to pperform a pressure
increase test in orde
er to determine the drying end in thhe case of double-
d
chamber freeze-drye ers or when using "Process B" in tthe "Manual" or
"Programm" mode (se e chapter 2.1.6
2 - "Proc
cess contro ol").
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2.3.2.4 Secondary
y drying (de
esorption)
After the free
f water h
has been withdrawn
w fro
om the prodduct, the waater that is
bound by y adsorptionn can now be
b removed in the "Seccondary Dry ying"
phase. Fo or this purpo
ose, the chaamber presssure is furthher decreas
sed
compared d to the "Maain Drying" phase and the shelf teemperature is further
increasedd.
The follow
wing screen nshot showss the param
meters that m must be deffined for a
"Seconda ary Drying" ssection:
Fig. 60 Pa
arameters of a "Secondary Drying" sectio
on
The shelff temperaturre and vacu
uum control systems w work in the same
s
manner as
a during the e "Main Dry
ying" phase. In additionn, the samee process
monitoring functions are also av
vailable via the sectionn parameterrs:
Safety
y pressure
Delta--Tshelf test
Delta--Tproduct test
LyoCoontrol-RX te est
Please reefer to chaptter 2.3.2.3 - "Main dry ying (sublimmation)" forr a

descriptio
on of the pa
arameters.
m the Delta--Tproduct testt, it is also possible
Apart from p to pperform a pressure
increase test in orde
er to determine the drying end in thhe case of double-
d
chamber freeze-drye ers or when using "Process B" in tthe "Manual" or
"Programm" mode (se e chapter 2.1.6
2 - "Proccess contro ol").
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2.3.3 E
Executing a freeze-d
drying pro
ogram/reciipe
In order to
o start a pro
ogram/recip
pe-controlled freeze-dryying proces
ss, the
"Programm" mode mu st be prese elected by clicking the ""Program" button
b (b)
in the "Process Conttrol" windoww.
Fig. 61 "P
Process Contro
ol"
As a resuult, a window
w is opened d that showss the prograam locations in which
the user programs/re
p ecipes are stored.
s s list includees the locations that
This
are occuppied both in the controll system and on the SC CADA PC as a well as
the prograam locationns that are occupied
o on
nly on one sside.
If a progra
am locationn is selected
d that contains differennt program data
d on the
PC and inn the controol system, a synchronissation windoow will be opened
o (s.
chap. 2.3.1 - "Creatiing/modifying a freeze-drying prrogram/rec cipe ").
Fig. 62 "P
Program" mode de program/rrecipe comparrison followingg the selection of a program
location with
h non-identicaal data on the PC and in the
e control systeem
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The progrram/recipe version tha at is to be ex

xecuted muust be copied to the
respectivee other side
e by clicking
g one of the e buttons "
" (a) or "
" (b).
Then, thee point as off which the program/recipe is to bee executed must be
defined.
Fig. 63 "P
Program" mode
de defining th
he start point for
f the executiion of the prog
gram/recipe
The execution as of the start of the first "Frreezing" secction is the default
setting (start section : 2, start tim
me: 0:00). This setting ccan remain
unchange ed when pro oducts with room temp perature aree loaded ontto the
shelves inn the "Stand dby" status (the shelf teemperaturee in section 1 that
representts the start vvalue for the temperatu ure ramp inn the first "Freezing"
section must
m also be e set to roomm temperatu ure).
If the prod
duct that is to be place ed on the shhelves has bbeen prefrozen
externallyy, the shelve es must be precooled to t the produuct tempera ature in
order to prevent
p the product from thawing on o the shelvves. In this case, the
start point for the exe ecution of thhe program/recipe musst be sectio on 1
("Precooling") and th he shelf temmperature in section 1 m must be sett to the
product teemperature e.
However,, it is also p ossible to select
s any other point oof time within the
program/rrecipe as th he start poinnt for the ex
xecution. Thhis is necessary if the
system must
m be swittched from the t "Manual" mode to tthe "Progra am" mode
during a running
r pro cess.
The start point can b be defined in arly comforttable manner via the
n a particula
buttons "SStartup secction" (i1), "SStart phase"" (i2), "Start time" (ii1), and
a "Start
temperatu on "Startup section" (i11) has been clicked,
ure" (ii2). Affter the butto
the sectioon for startinng the program/recipe execution ccan be chan nged with
the aid off a numerica al keypad thhat will be displayed.
d T
The start tim me within
the sectioon is presum med to be "0 on start) (thhe labelling of the
0:00" (sectio
buttons (i1) (ii2) chhanges acco ordingly andd indicates the data of the currentt
selected start
s point). A perpendicular blue line (see thee arrows) marks m the
selected start
s point in n the diagra
am. Alternatively, the sstart of the first
f section
of one of the drying p phases can n be selected by clickinng the button n "Startup
phase" (i2) repeatedlly.
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When thee system is switched from the "Ma anual" modee to the "Pro ogram"
mode durring a runni ng process, the start point
p for the execution of
o the
program/recipe mustt be in the drying
d phase that is cu rrently being
executed in the "Man nual" mode.
NO
OTE This means that, in tthis case, th
he start phase is fixed aand that only
sections within
w this d
drying phase can be se elected as thhe start sec
ction.
In a second step, it iss possible to

t change th he start poinnt within the
e selected
section. This
T can be realised by y clicking the e button "Sttart time" (iii1) and by
specifyingg the time b
between the e start of thee section annd the desirred start
point. In order
o to starrt at a specific shelf tem
mperature w within the se ection, this
temperatu ure can be sspecified by y clicking thhe button "S
Start temperrature" (ii2).
Start section i1 Fre

eeze-dryer in ""Standby":
Any desired secttion number of
o the
selected freeze-ddrying program
m/recipe.
Sw
witching from ""Manual" to "P
Program"
during a runningg process:
Any section nummber within thee current
dry
ying phase.
Start phase
e i2 Fre
eeze-dryer in ""Standby":
Pre
ecooling/Freezzing/Main
Dry
ying/Secondarry Drying.
Sw
witching from ""Manual" to "PProgram"
during a runningg process:
Current drying pphase (fixed).
Start time ii1 0 (duration off the start secttion selected

above) 1 min.
Exception: sectioon 1 (precooling):
0 (fixed)
Start tempe
erature ii2 Any value of thee shelf temperaature set
value ramp of th e start section
n selected
abo
ove.
The progrram/recipe can now be e started. In

n order to chheck the settings, the
program number,
n pro
ogram name, programmed total dduration, tota al number
of section nt in the pro
ns, start poin ogram/recip pe as well ass the date and
a time of
the expeccted processs end will be
b displayed d.
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Fig. 64 "P
Program" mode
de settings co
oncerning the program/recippe execution and
a the
expected prrocess end
In order to
o check thee program/reecipe itself (i.e. the secction param
meter sets
and the additional
a eneral parameters), it can
ge c be openned in the program
p
editor by clicking the
e button "Sh
how User Prrogram/Reccipe" (i).
Fig. 65 "P
Program" mode
de checking the
t program/re
ecipe parameeters in the pro
ogram editor
This winddow provide es the samee functions for
f checkingg the prograam
paramete ers as for the
e creation/m
modification
n of a freezee-drying
program/rrecipe (see chapter 2.3 3.1 - "Creatting/modifyying a freez
ze-drying
program//recipe "). H However, thhe program//recipe cannnot be moddified or
deleted.
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The execution of the e selected frreeze-drying g program/rrecipe as off the

king the "Ruun" button on the
specified start point ccan be starrted by click
toolbar.
If section 1 ("Precoo ling") has been
b ed as the sttart section, the
selecte
shelves are
a brought to the spec cified precoooling tempeerature as quickly as
possible. The freeze e-dryer then remains in this state sso that the shelves
s
can be loaded. Afterr this, the prrogram/recip pe can be sswitched to section 2
by clicking the "Run"" button, wh hich is now labelled
l "Prrogram Con ntinue".
If section 2 or a subssequent sec ction has beeen selectedd as the staart section,
the "Run"" button doees not need to be clicke ed again.
From now w on, the pro
rocess will run
r fully auto omatically, controlled by
b the
program/rrecipe, untill it ends. Du
uring the proocess run, tthe processs can be
monitored d with the a
aid of the windows "Pro ocess Graphhics", "Proccess
Events", "Mimic
" Diaggram", and "Alarm List"". In the casse of doublee-chamber
systems oro if "Processs B" is appplied, a pres
ssure increaase test cann be
performed d during thee drying pha ases "Main Drying" andd "Seconda ary Drying"
in order to
o determinee the end off the drying process (seee chapter 2.1.6 -
"Process s control").
The proce ess run cann be abortedd at any time by clickinng the "Stan
ndby"
button onn the toolbarr and by confirming thee subsequeent safety inquiry. As
a result, the
t freeze-d dryer will be
e switched to "Standby"".
NO
OTE
If the func
ction "Aerattion, Stoppe ering, Storagge" is activaated in the
program/rrecipe (provvided that is s included in
n the freezee-dryer vers sion), the
product vials
v will be ssealed autoomatically under a definned partial vacuum
after the end
e of the d drying proceess (option)). Then, theyy will be stoored on the
shelves ata a defined temperaturre until the freeze-drye
f er is switcheed manuallyy
to "Standby" followin ng the confirrmation of a message indicating th he end of
the progra am (see cha apter 2.3.1 - "Creatingg/modifying g a freeze-d drying
program//recipe "). IIf this is nott the case, the shelf temmperature anda
chamber vacuum willl be mainta ained at the set values of the end of the last
section an nd the ice ccondenser will
w be coole ed further unntil the freeze-dryer is
switched manually to o "Standby"" following thhe confirmaation of a message
indicatingg the end off the program. This prevents the pproduct from m being
remoisten ned by any thawing condensate when w the com mponents anda units off
the freezee-dryer are switched offf without su upervision.
Once the freeze-drye er is in "Sta
andby", the chamber
c caan be aerate ed and the
product can
c be remo oved.
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2..4 Aeration
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2.4 A
Aeration
After the end of the ffreeze-dryin
ng process anda after thhe freeze-drryer has
been man nually set to
o "Standby", the chamb ber can be aaerated.
If the free w an auto omatic aerattion valve, the
t
aeration function
f cann be controllled via the LPCplus softtware. The "Aeration"
mode can n be preseleected by clic
cking the buutton of the same name (c) in the
"Process Control" wiindow.
Fig. 66 "P
Process Contro
ol" - "Aeration
n"
If the free
w a shelf movement system, the e product
he chamber with loosely inserted Lyo
vials in th L stopperrs can be se
ealed
manually under partiial vacuum.
For stopppering, all off the shelve

es that are used
u must bbe loaded completely
and with identical pro oduct vials in order to prevent
p thee shelves an
nd guide
rods as well
w as the vvials from be eing damag ged or brokeen.
If the she
elves are onnly partially loaded,
l addditional emppty vials with
h inserted
CAUT
TION stoppers, or spacerss (of the sam me height), must be poositioned on n the
shelves inn order to e
ensure a uniiform distribbution of thee force. Suittable
spacers are
a available e upon requ uest.
If stopperring is desirred, the parttial vacuum under whicch the vials are to be
sealed caan be adjustted by clicking the valu ue "Aerationn Pressure" (i) and
with the aid
a of a num merical keyp pad that will be displayeed.
Stopperinng must be performed at a chamber pressuree below 900 0 mbar in

order to prevent
p the stoppers fro
om being pushed out oof the vials at
a low
ambient pressure.
p
NO
OTE
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Target pres
ssure for aerattion i 0.0
0010 mbar 1000 mbar
The aerattion processs can then be started by

b clicking tthe "Run" button on
the toolba
ar.
The aerattion processs can be ab borted at an

ny time by cclicking the "Standby"
"
button onn the toolbarr and by confirming the
e subsequeent safety inquiry. As
a result, the
t freeze-d dryer will be
e switched to "Standby"".
NO
OTE
When the e set partial vacuum is reached, a correspondding message will be

displayedd and the fre eeze-dryer will
w automatically switcch to "Stand dby". Then,
the Lyo sttoppers can n be presse ed into the product
p vialss by way of the
moveable e shelves.
In order to
o be able too open the chamber
c an
nd remove tthe product, preselect
once again the "Aera ation" mode al aeration aand set the "Aeration
e for the fina
Pressure"" (i) to 10000 mbar. Whe en the "Run n" button is clicked agaain, the
chamber will be aera ated to atmo ospheric pre essure. How wever, when
1000 mba ar are reach hed, the free w not immeediately switch to
eze-dryer will
"Standby"". Instead, tthe control system
s for the
t aerationn to atmosp pheric
pressure remains acctive for ano other 10 min nutes (in thee case of fre
eeze-
dryers witth a door co ontact, it rem
mains active e only until the door is opened).
If stopperring is not d esired, the aeration up p to atmosp heric pressure can be
performed d directly.
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2.5 D
Defrosting
Before a new freeze--drying proc cess can bee started, it is necessary to
remove th he ice from the ice conndenser.
If the free
w a quick k defrosting device, the
e defrosting
of the ice condenserr can be con ntrolled via the LPCplus software. In
n the
"Standby"" status of tthe freeze-d
dryer, the "D
Defrosting" mmode can beb
preselected by clicki ng the butto
on of the saame name ((d) in the "PProcess
Control" window.
w
Fig. 67 "P
Process Contro
ol" - "Defrostin
ng" (different types
t of freezee-dryers)
Dependin ng on the de efrosting me ethod that iss used by thhe freeze-dryer (heat
transfer medium,
m hott gas, hot water
w (externnal), or elecctric) and the
equipmen nt status of the freeze-d dryer (manu ual or autom matic aeration and
media dra ain valves) tthe defrosting process may differ greatly. As a result,
the param meters that must be set also vary from f freezee-dryer to fre eeze-dryer.
The defro osting proce ess is alway ys timer-conntrolled. Thee duration can c be
adjusted by clicking tthe value "D Defrosting time" (i) andd with the aiid of the
numerical keypad tha at will be displayed. In the case off freeze-dry yers that
use a hea medium, hot gas, or ele
at transfer m ectricity for ddefrosting, the
temperatu ure of the d efrosting medium
m or off the heatingg mat can be b
specified by clicking the value "Defrosting temperature
t e" (ii). If the
e freeze-
dryer is equipped witth an autom matic media drain valvee, the user can c also
decide wh hether a me edia drain process
p for emptying
e thhe chamberr shall be
started au utomaticallyy after the defrosting
d prrocess. To ddo so, click the button
(iii). The labelling of tthe button indicates the current seetting. "Med dia Drain"
is a separrate operatiing mode th hat can alsoo be preseleected directly by
clicking thhe button off the same name (f) in the "Processs Control" window.
This is alsso where it must be pa arameterised (see chappter 2.7 - "M Media
drain").
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Defrosting time
t i 1 min
m 10 h
Defrosting temperature
t ii +20C +60C
C
Automatic start
s of the "Me
edia Drain" iii yess / no
mode Atttention: The duuration of the draining
pro
ocess must bee set in the "Media Drain"
moode.
The defroosting proce

ess can then
n be started
d by clickingg the "Run" button on
the toolba
ar.
The defroosting proceess can be aborted

a at any
a time byy clicking the
e
"Standby" button on the toolbarr and by con nfirming thee subsequen
nt safety
inquiry. As
A a result, tthe freeze-d
dryer will be
e switched tto "Standby".
NO
OTE
If the auto
omatic startt of the "Media Drain" mode
m is acttivated, the freeze-
dryer will switch to th
his mode wiithout any user
u notificaation after th
he set
defrostingg time. Once e the time that
t was sett for this moode has elapsed as
well, a co
orresponding g message will be disp played and tthe freeze-d dryer will
immediately switch to o "Standby". If the autoomatic startt of the "Me edia Drain"
mode is deactivated,
d , a message e will be dis
splayed afteer the defros sting time
and the system will a automatically switch to "Standby".
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2.6 P
Performing a leak testt
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2.6 P
Performin
ng a leak
k test
Epsilon frreeze-dryers
rs offer a fully automatic leak test ssequence.
The "Leakage Test" mode can be b preseleccted by clickking the button of the
same nam me (e) in thee "Process Control" window if the freeze-drye er is in
"Standby"".
Fig. 68 "P
Process Contro
ol" - "Leakage
e Test"
The desirred test dura
ation can be e specified by clicking the value "T Test
h the aid of the numerical keypad that will be displayed.
Duration" (i) and with
In addition, the "Cha
amber Volum me" (ii) musst be specifiied. The oth her test
paramete ers, which d efine the te
est condition
ns in particuular, are fixe
ed and
stored in the LSCplus control sysstem. They can
c be view wed via the control
panel of the
t control ssystem.
Test duratio
on i 10 min 18 h
Chamber vo
olume ii 0.1 l 9999.9 l
The leak test can the

en be starte
ed by clickin
ng the "Run"" button on the
toolbar.
The leak test can bee aborted at any time by

y clicking thhe "Standby
y" button
on the too
olbar and byy confirming
g the subse
equent safetty inquiry. As
A a result,
the freeze
e-dryer will be switched
d to "Standb
by".
NO
OTE
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g
The test sequence

s ccomprises several phas ses that aree displayed in section
(c) of the "status barr" in the lower area of th
he screen dduring the execution:
e
Warm-up: Warm-u up of the va

acuum pump, cooling oof the ice co
ondenser,
and adjjustment of the shelf te
emperature in accordan nce with
the testt conditions.
Evacuatio
on: Evacua ation of the chamber
c in accordance
ce with the test
conditio
ons.
Vacuum Waiting
g time after the completion of the eevacuation so that a
stabilisation: uniform
m pressure results
r in alll parts of thee chamber.
Measure-- Monitorring of the chamber
c vacuum whilee the ice con ndenser
ment: and she elf temperattures are maintained
m aas defined by
b the test
conditio he end of the test durattion (i), the leak rate
ons. After th
is calcuulated based d on the diffference bettween the end
e and
start va
acuum, the test
t duration, and the cchamber vo olume (ii).
This vaalue is comp pared to the
e maximum permissible e leak rate
that is ccalculated by
b the LSCplus
p control ssystem as a function
of the teest duration
n and in commpliance witth the spec cification of
the Parrenteral Soc esult is thenn displayed as a
ciety. The re
messag ge in a pop--up window.
Fig. 69 "P
Process Contro
ol" - "Leakage
e Test" resullt message
Aeration: Aeratio n of the cha
amber to atmospheric ppressure.
When thee aeration iss complete, a corresponding messsage will be

e displayed
and the frreeze-dryerr will automa
atically switch to "Stan dby".
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2.7 Media
M drain
n
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2.7 M
Media dra
ain
Before a new freeze--drying proc cess can be e started, it must be en nsured that
there is no residual mmedium (coondensate) in the cham mber or drain n pipes,
since thiss may preveent the desirred drying vacuum
v from
m being rea ached.
If the free
w an auto omatic mediia drain valv ve, the
chamber draining pro ocess can be
b controlleed via the LP PCplus softw
ware. The
"Media Drain" mode can be preselected by y clicking thee button of the same
name (f) in ol" window iff the freezee-dryer is in "Standby".
i the "Proccess Contro
Fig. 70 "P
Process Contro
ol" - "Media Drain"
D
The drainning of the cchamber is performed in a timer-coontrolled manner. The
duration can
c be set b by clicking the Media drain valve open
t value "M ning time"
(i) and witth the aid o
of a numericcal keypad that will be ddisplayed.
Media drain
n valve openin
ng time i 1 min
m 10 h
In order to
o start the p
process, clic
ck the "Run
n" button on the toolbarr.
The drainning of the cchamber can be aborte ed at any tim

me by clicking the
"Standby" button on the toolbarr and by con nfirming thee subsequennt safety
inquiry. As
A a result, tthe freeze-d
dryer will be
e switched tto "Standby".
NO
OTE
After the preset time

e has elapse
ed, a corres
sponding meessage will be
displayedd and the fre
eeze-dryer will
w automatically switcch to "Stand
dby".
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3.11 User adm

ministration
n
3 Adm
ministra
ation fu
unctions
s of the softwa
are
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3.1 U
User adm
ministratio
on
The "Use er Administra

ration" is only available if the acce ss protectio
on is
active in the
t LSCplus control systtem of the connected
c ffreeze-dryer.
NO
OTE
The "User Administra ed to make general saafety settings

ation" is use
concerninng the user log-in, to crreate new users,
u to chaange the se ettings of
the user accounts,
a a
and to modiffy the assignment of thhe various program
p
functions to the six h
hierarchic usser levels.
The "User Administra ation" windoow is opene ed via the bbutton of the e same
name (J) on the toolb bar. In the factory
f setting, the useer administra ation is
only available to useers of the "A
Administrato or" level (thiss setting ca
an be
changed by an admi nistrator). The
T users of the other llevels can only o
change thheir own pa asswords aftter the selection of "Usser Administration" (0).
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3.1.1 S
Safety setttings
The buttoon "Settingss" (a) can be all up the gloobal safety settings
e used to ca
for the us
ser log-in.
Fig. 71 "U
User Administrration" "Settiings"
After the button "Passsword Para
ameters" (a
aI) has beenn clicked, the safety
settings can
c be edite ed in a sepa
arate window
w.
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3 Adminis
stration fun
nctions of the
t softwarre
Fig. 72 "U
User Administrration" "Settiings" "Passw
word Parametters"
wing param eters must be defined for the acceess protection:
The follow
(i) 20 day y before thee "Password d Lifetime" (1 364 ddays) expire es, every
user will
w be reque ested to cha
ange his/he er passwordd. If the user fails to do
so, thee correspon nding user account
a will be automaatically deacctivated
after the expiry o f the "Passwword Lifetim
me". In this ccase, it can
n only be
reactivvated by ann administraator under "User" - "Ed it User" (see chapter
3.1.2 - "Creating g/editing a user
u accouunt ").
(ii) "Runtiime Passwo ord Timer" (1
( 150 min.)
m specifiees the time until the
autommatic log-outt of a user. The countd down will bee restarted every
e time
the usser performss an operattion. After th
his time hass elapsed, and
a if a
buttonn requiring tthe authentication of th
he user is cl icked, the lo
og-in
screen n will be op
pened once again.
(iii) "Length of Passw word" (1 20 characte ers) specifiees a minimu um number
of chaaracters for the passwo ords.
(iv) If the number of ""allowable log-in attem mpts" (3 999 attempts) is
exceeeded, the usser account will be auto omatically ddeactivated.. In this
case, it can only be reactivated by an administrato
a or under "Us ser" - "Edit
User" (see chapt er 3.1.2 - "CCreating/ed diting a useer accountt ").
(v) The buttons (v1) a and (v2) are
e used to deefine whetheer, after thee
authentication of the user in the log-in screen,
s the button that has been
clicked beforehan nd must be clicked aga ain, or whetther the sele ected
on will be exxecuted immediately (a
functio a dark blue frame arou und one of
the tw
wo buttons in ndicates the
e current seetting).
Apart fromm the actuaal printing off the safety settings, thhe button "P
Print" (2)
also offerrs a corresp
ponding prin a well as thhe output in PDF
nt preview as
under "Prreview" - "SSave As".
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3.11 User adm

ministration
n
3.1.2 C
Creating/editing a us
ser accou
unt
The butto
on "User" (b
b) can be us
sed to call up the user-sspecific setttings.
Fig. 73 "U
User Administrration" "Userr"
First, all of
o the existinng user acccounts, inclu uding the usser name,
identificattion, and levvel as well as
a the rema aining numbber of days until the
expiry of the
t passwo ord and the account sta atus (enableed/disabled), are
listed.
In order too create a nnew user ac ccount, clickk the buttonn (b1) to ope
en an
empty forrm for enterring the use er data. Clicking the buttton (b2) opens a user
account that is marke ed on the list for editing in the samme form.
Fig. 74 "U
User Administrration" "Userr" "Create User"/"Edit
U Useer"
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3 Adminis
stration fun
nctions of the
t softwarre
The form requires th e following information

n concerningg the user:
(i) The "U User Name " is the reall name of th he user.
(ii) The "U User Identiffication" is the chosen log-in namee.
(iii) In order to preven nt a passwo ord from being misspellled, it mustt be
entere
ed into the ffield (iii1) an
nd repeated in the field (iii2). When
n entering a
passwword, the miinimum num mber of characters thatt has been specified
s
underr "Settings" - "Password d Parameteers" must bee complied with (see
chapteer 3.1.1 - "S
Safety settiings"). Upper- and low wer-case lettters as well
as nummbers can be used.
(iv) The "U User Level"" defines the e access rig
ghts of the uuser. The us ser is
assignned to one o of six hierarrchic user le
evels with thhe aid of the
e arrow
button
ns. The folloowing user levels
l are available
a (soorted by deccreasing
numbe er of rights)):
- Adm
ministrator (6)
- Calibration (5)
- Maiintenance (4)
- Eng
gineer (3)
- Use
er (2)
- Gue
est (1)
For information cconcerning thet specification of thee available functions of
the LPPCplus softwaare to the various
v userr levels, seee chapter 3..1.3 -
"Definning the us ser levels".
(v) A user account ccannot be de eleted. How wever, it cann be set to "disabled"
"
by clic
cking the bu event log-inns with this user ID. If
utton (v2) in order to pre
the paassword lifeetime expirees or the ma aximum num mber of perm missible
log-in attempts iss exceeded,, the user account will be deactiva ated
autommatically. In this case, itt can be rea
activated byy way of thee button
(v1) (a
a dark blue fframe aroun nd one of thhe two buttoons indicatees the
currennt status).
Apart from
m the actua al printing off the list of user
u accounnts, the buttton "Print"
(2) also offers
o a corre
responding print preview as well aas the outpu ut in PDF
under "Prreview" - "S
Save As".
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3.11 User adm

ministration
n
3.1.3 D
Defining th
he user lev
vels
The hieraarchic user llevels are defined
d by a table that iincludes the
e number
of the use d for the various functioons of the LPCplus
er level thatt is required
software. Higher use er levels hav ve all the rig
ghts of the llevels below
w.
The tablee can be cal led up via the button "U User Level"" (c).
Fig. 75 - "U
User Administra
ation" "Userr Level"
When the
e button "Asssign Functiions" (cI) is clicked, thee factory-set
assignme
ent can be cchanged.
Fig. 76 - "U
User Administra
ation" "Userr Level" "Ass
sign Functionss"
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3 Adminis
stration fun
nctions of the
t softwarre
In order too assign a sspecific LPC Cplus function to anotheer user level, select
this functiion on the liist. Then, click the buttton (i) that ccorresponds s to the
new user level in ord der to enter the corresp ponding num mber into th
he field
behind the function. Clicking "O OK" confirms s the modificcation so th hat the new
assignme ent will be a
applied.
By clickin
ng the button n "Default" (ii) and by confirming
c a safety inquiry, all of
the assign nments will be reset to o the defaultt factory setttings.
Apart fromm the actua al printing off the assignment table,, the button "Print" (2)
also offerrs a correspponding prin nt preview asa well as thhe output in PDF
under "Prreview" - "SSave As".
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3.2 D
Documen
ntation
A process s documenttation includ des the proccess diagraam that show ws the
developmment of the m measurands s over the duration
d of tthe processs as well as
the proceess event lisst that provid
des an overview of thee course of thet
process inn seamlesss chronologiical order.
Since thee process re ecords are saved
s as bin
nary data thhat are com mpressed
by way off a special a algorithm, th
he original data
d can bee viewed, prrinted, and
exported only via the e documenttation function of the LP PCplus softw
ware.
Since thee documenta ation functio
on has no effect
e on thee actual processes or
settings, iti can also b
be selected outside of a running pprocess reco ording
a even wiithout a con
process and nnection to a freeze-dryyer. It can be
b called
up by clic
cking the "D Documentatiion" button (K) on the ttoolbar.
Fig. 77 - "C
CHRIST LPCpluus start screen
n"
If several connectionn ports are configured
c or
o include ddata, a dialoog window
for selecting the dataa source will be opened d. The addiitional data source
"USB-Stic aged as a fiffth connection port. It m
ck" is mana may includee imported
record file
es that are m
made availa able offline. These filess may either originate
directly from the LSCCplus control system (viaa the optionnal LSCplus function
f
"USB process record ding") or the
ey have bee en exportedd from the LPC
L plus
software by way of th he "Christ Support"
S fun
nction (see below).
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Fig. 78 "P
Process Docum
mentation" (co
onnection portts 1 4)
If the data
a source "U
USB-Stick" is s selected, two additio nal buttons are
available:: "USB-Impo he record filees from the mobile
ort" (8) for importing th
data carriier and "Dellete" (9) for deleting an
n imported ffile.
Fig. 79 "P
Process Docum
mentation" ("U
USB-Stick")
The data storage secctor for the additional connection
c port "USB-SStick" is
not intend permanent storage of record files.. This secto
ded for the p or is not
i the data backup. Ins
included in stead, it is solely
s intendded for view
wing and
documenting externa al record file
es.
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The window "Processs Documen ntation" includes a list oof the recorrd files. It
distinguisshes betwee en files that have not been saved by a backup
("compres ssed") and files that ha ave already been copieed into a ba ackup
directory ("backed up p") (see cha apter 3.3 - "Data
" backu up"). The files can be
selected with
w the aid d of the two buttons "Co ompressed"" (i) and ("B Backed up"
(ii). A dark blue fram e around one of the tw wo buttons inndicates the e current
selection..
In order too be able to
o find a specific record file in a parrticularly coomfortable
manner, thet arrow b uttons abov ve the table columns 4 and 5 can be used to
define the e batch data e displayed in these coolumns (see
a that will be e chapter
2.1.2 - "UUser log-in and proces ss recordin ng ").
Measurement value e assignme ent: Via "Me

easured Vaalue" (1), the
e
measuran nds that are
e to be displayed are assigned to tthe 12 chan nnels (pen
colours) of
o the softwaare plotter.
Fig. 80 - "Process Docum

mentation" - "M
Measured Valu
ue"
The labelling of the bbuttons (i) (xii) next to the pen ccolours indicates the
measuran nds that aree currently assigned
a to the colourss. In order to
o assign a
different measurand
m to one of thhe colours, click the coorresponding button
and selec ct the desire
ed measura and from a list. The asssignment that is made
here will be
b saved fo or this recorrd file, but it can be chaanged at any time.
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Printing parameters s: The butto

on "Print Se
ettings" (6) ccan be used
d to
influence the layout a
and scope of
o the hardccopy of the process ev vent list.
Fig. 81 - "Process Docum

mentation" - "P
Print Settings"
Clicking the buttons (ii) (vi) activates (da ark blue framme) or deac ctivates the
following options:
Coloured represe entation of different
d enttries
Date in every eve ent line (dea
activated = only when tthe date ch hanges)
Printin ng of set va lues (e.g. password
p se
ettings, settiings for "Cy
yclic
Events", set valu es for "Man nual", set va
alues for "Prrogram", se et values of
the auuxiliary proccesses)
Printin ng of valuess of selected d measuran nds that aree entered att regular
interva
als ("Cyclic Events")
Printin ng of "Leak Test" entrie es
Clicking the button (ii) once or twwice activates or deacttivates all off the
options toogether.
Printing the
t proces ss documentation: Ap part from thee printing off the
process documentat
d tion includin
ng the proce
ess diagramm and eventt list of the
entire rec
cording periood, the "Print/Preview" button (2) also offers a
corresponnding previe ew and the output in PDF. In addittion, the underlying
raw proceess data ca n be exportted into othe
er programss in various s different
formats fo
or further evvaluation.
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Fig. 82 "D
Documentation
n" - "Print/Prev
view"
The butto
ons "Printer"" and "Preview" (i) are used to preeselect the output
o
device (printer, moniitor) (select "Preview" for
f the outpput in PDF and
a for the
export of raw processs data).
Printer: Click
C the buttton "Printerr Setup" (ii) to select a specific printer and to
perform printer-spec
p cific adjustm
ments. When n the "Printeer" has been
preselected, there arre various additional
a opptions (num mber of copies, sorting
("Collate""), and doubble-sided prrinting ("Dup plex")) (iii).
Preview: The preview w offers butttons for scrrolling (1-4)), zooming in/out (7-
10), printiing (6), as w
well as for th
he output in
n PDF and ffor the expo ort of the
raw proce ess data (5)).
Fig. 83 "D
Documentation
n" - "Print/Prev
view" "Previe
ew"
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Save as: The button "Save As" (5) can be used to savve the proce ess
diagram in PDF or to o export thee raw proces ss data for ffurther evaluation in
MS Excell, SQL, XM ML, or HTML L format to any desiredd directory. After the
selection of the desirred file form
mat by way of o the butto n (iii), the ta
arget
directory that has beeen used mo ost recently mat will be suggested.
y for this form
A differen
nt target dire
ectory can beb specified d by way of the drive/directory
selection box (i). Thee button "Ne ew Folder" (ii) on the riight can be used to
create a new
n within the directory that is selectedd at present. The
folder w
t export fiile will be ge
name of the enerated auutomaticallyy based on the name
of the pro
ocess record d file and th
he prefix "Do ocu_". The file extensio on
depends on the sele ected file forrmat.
Fig. 84 "D
Documentation
n" - "Print/Prev
view" "Previe
ew" "Save A
As"
Clicking the "OK" bu tton starts the
t storage process. If there is alrready a file
of the sam
me name in n the target directory, a correspondding messa
age will be
displayedd in a pop-u p window.
e button "Prrint" (6) can be used to print basedd on the pre

Print: The eview.
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Fig. 85 "D
Documentation
n" - "Print/Prev
view" "Previe
ew" "Print"
Process diagram: W When the button "Proce ess Graphiccs" (3) is prressed, the
process diagram
d willl be created
d based on the data of the selecteed record
file. It will be displaye ame manner as the proocess diagra
ed in the sa am of a
running process
p d also with the same dis
and splay optionns (see chaapter 2.1.4 -
"Process s Graphics"").
(a) Timeline: T ngth of the timeline reprresents the total

The total len
recording tiime. The arrea that is marked
m in grrey indicate
es the
position an d length of the period that
t is curreently displayyed
in the graphh.
(b) Arrow butto
ons: They can be used to shift thee period thatt is to
ed in the dirrection of the start of thhe recording
be displaye g
process or in the direc
ction of the present
p poinnt of time.
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(c) Hairline: Th
his line can be used to read off preecise
measureme ent values on
o the graph.
(d) Arrow butto
ons for positioning the hairline.
(e) Value table
e: It includes
s the values
s of the meaasurands th hat
are represe
ented on the e graph at the point of time that is
marked by the hairlinee.
Fig. 86 "P
Process Docum
mentation" Process
Grap
phics
The "Print" button (6 ) provides the
t same ou utput optionns as for a running
r
process (including th
he export off raw data). The name of the expo ort file will
be genera ated automaatically bas
sed on the name
n of the record file and the
e file extension depends on the seelected file format.
prefix "Grraph_". The
Unlike the
e measurem ment value assignmentt that is desscribed abov ve, an
assignme ent that is pe erformed heere via "Measured Valuue" (5) is on
nly
temporaryy. It will nott be saved for
f this recoord file.
NO
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LyoControl calcula ation: The button

b "LyoCControl calcculation" (4)) is used to
support thhe process developme ent. It enable es the autommatic deterrmination off
the charaacteristics off a given prroduct that are
a essentiaal for the fre
eeze-drying
process. For this purrpose, the course
c of the freezing pprocess must be
recorded by a LyoCo ontrol senso or that is immersed intoo the product (see the
separate operating in nstructions of the LyoC Control meaasurement system).
s
After the selection off a process recording thus createdd, clicking th he button
"LyoControl calculatiion" opens the print pre eview of a pprocess diagram with
the two fix
xed measurrement valu ue curves
Produuct temperatture value measured

m by
b the LyoC
Control sens sor
(Lyo product)
p
Produuct resistancce value me
easured by the LyoConntrol sensorr
(LyoR
Rx)
and with the

t lines thaat are required for dete
ermining thee product
characterristics:
In addition, the value
es that were
e determineed for freezee-drying the
e product
are also displayed:
d
(a) Freezing point

(b) Assoc ciated vacuu
um in accorrdance with the vapourr pressure curve
c
(c) Sugge ested drying
g vacuum fo g temperatuure that is 10 K below
or a freezing
the fre
eezing pointt
(d) LyoCo ontrol-RX va
alue in the frozen
f state
e (upper RX
X asymptote e)
(e) LyoCo ontrol-RX va
alue in the liquid
l state (lower RX aasymptote)
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Fig. 87 "P
Process Docum
mentation" - "L
LyoControl calculation"
Just like in the print p
preview of the
t normal graphical
g prrocess reprresentation,
the variouus output op ptions are also
a available in this caase via the buttons
b
"Print" and "Save as ".
Christ suupport: Wh en the butto on "Christ Support"

S (7)) is clicked, all of the
data that are requireed for a proc
cess analysis are copieed into a dirrectory so
that they can be han nded over too the Christ support de partment. This
T
directory will be disp
played in a special
s wind
dow immediiately after thet export.
Fig. 88 "P
Process Docum
mentation" - "C
Christ Support"
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USB impport: (only in

n the case of
o the "USBB-Stick" dataa source) The button
"USB-Imp
port" (8) cann be used too read in ex
xternal recoord files for evaluation
e
and documentation w with the aid of the LPC
Cplus softwaree.
Fig. 89 "P
Process Docum
mentation" - "U
USB-Import"
Delete: (o
only in the ccase of the "USB-Stickk" data sourrce) The buttton
"Delete" (9)
( can be u used to deleete external record filess that were read in.
Unit seleection: The button "Select Unit" (10) can be uused to swittch to the
record file
es of a diffe
erent connec
ction port.
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ata backup
p
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3.3 D
Data back
kup
The data backup fun nction that is
s integrated
d in the LPCCplus softwarre can be
used to copy processs record file es into any desired
d drivve/directory.
In order to
o call up thee data backkup functionn, click the bbutton "Backup" (L) on
the toolba
ar. If there a
are several connection ports that aare configurred or
include daata, a dialogg window fo or selecting the data soource will bee
displayedd.
Fig. 90 "B
Backup"
The data backup dia alog offers a dual-windo ow view. Thhe upper window
shows all of the reco
ord files thatt have not been
b saved in a backup p yet, while
the lower window inccludes all off the files th
hat already eexist in the current
target dire
ectory. The complete path
p towards this targeet directory is
displayedd right above
e.
In order to
o change thhe target dirrectory, click the buttonn "Folder" (2
2).
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Fig. 91 - "Backup" - "Fold

der"
The drive e/directory sselection bo ox (i) can be e used to sppecify a diffeerent target
directory. The button n "New Fold der" (ii) on th
he right cann be used to o create a
new direc ctory/folder in the one that t is curre
ently selecteed.
In order too save filess by way of a backup, they must bee selected in i the
upper list. In order too select sev veral succes ssive files, sselect the uppermost
file and cllick the buttton (iii) in orrder to activ
vate the mu ltiple selecttion mode.
Then, select the lowe ermost file anda comple ete the selecction by cliccking the
button (iii) again. The e selected files
f are now w displayedd on a dark blue
background (the sele ection can be b cancelled d by clickingg the buttonn (iii) once
again).
Clicking the button "S Save File(s)" (3) copies the selectted record files f
directly in
nto the set taarget directtory. After th he backup, the original file
extension n ".??c" ( = ccompressed d) is converrted into ".???x" ( = saveed) in the
original directory as w well as in thhe target dirrectory.
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3.4 E
Extras
The buttoon "Extras" ((M) on the "toolbar"
" pro
ovides acceess to the general
settings concerning
c tthe connecttion ports or the assocciated recordd files as
well as to
o the mainteenance data a of the freeeze-dryers thhat are connected to
the ports. If several cconnection ports are co onfigured o r include daata, a
dialog winndow for seelecting the data source e will be opeened. The additional
a
data sourrce "USB-Sttick" is man naged as a fifth
f connecction port. It may
include im
mported reccord files thaat are made e available ooffline (see chapter
3.2 - "Doccumentatio on").
Fig. 92 - "Ex
xtras" "Unit Name"
Unit nam me: When th he button "UUnit Name" (a) is clickeed, the name of the
unit (freezze-dryer) th hat is displayyed on the toolbar of thhe LPCplus screen
s and
in the title
e of all of thee printouts can be specified as deesired in thee field (i).
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Fig. 93 - "Ex
xtras" "Com
mpany Name"
Company y name: W When the buttton "Compa any Name" (b) is clicke ed, the
company logo that w will be used in the titles of all of thee printouts can
c be
entered next
n to the ccompany na ame in the field (i). For entering the logo, a
file selecttion dialog wwindow will be opened following thhe confirma ation of the
button "Company Lo ogo" (ii).
Fig. 94 - "Ex
xtras" "Batch
ch Data"
Batch da ata: Under ""Batch Data a" (c) and by
y clicking thhe button (i1), the
batch datta acquisitioon form can be configured so that the data of the
previous process are e taken ove er. Clicking (i
( 2) deactivaates this settting (a
dark blue frame arou und one of the
t two butttons indicate tes the curreent
setting). In addition, the names (ii2) of the available
a baatch data input fields
can be cu ustomised, o or they can be reset too the defaultt factory setttings by
clicking th
he button "DDefault" (ii1).
)
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Fig. 95 - "Ex
xtras" "Backkup"
Backup: Under "Bacckup" (d), a period afte er which a bbackup file must
m be
saved at the
t latest a nd a target directory fo or the backuup can be defined.
The periood of time, w
which can be b specified after the buutton (i) hass been
clicked (1 364 dayys), determines the number of dayys after which (after
the creation of a bacckup file) a message
m eminding thee user of a due
re
backup will
w be displa ayed. This is s checked whenever
w a new recordding
process iss started. T
The setting "Off"
" deactiv vates the reeminder function. The
labelling of
o the butto n indicates the currentt setting.
The targeet directory ffor the backkup can be specified byy way of the e
drive/directory selecttion box (ii). The buttonn "New Foldder" (ii) on the
t right
can be us sed to creatte a new folder within the directoryy that is selected at
present. Alternatively
A y, the target directory can
c also be specified directly
d in
the "Backkup" window w (see chap pter 3.3 - "Data backup p").
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Fig. 96 E
Extras Cycllic Process Ev
vents
Cyclic ev vents: "Cycclic Process s Events" (e) offers the opportunity y to enter
the nume asurands that were sellected for th
erical valuess of the mea he process
diagram ("Process
( G
Graphics") toogether with h a time staamp into thee process
event list at regular i ntervals.
The butto on (ii) can be
e used to define the intervals betw ween the enntries (1
120 min). Clicking th he button (i) activates or
o deactivatees the optio on. The
labelling ofo the butto n indicates the currentt setting. Im mmediately after
a the
confirmattion of the ssetting with "OK",
" the firrst entry into
to the proce
ess event
list will be
e performed d.
The value es of the meeasurands that

t have been assigneed to the 12 2 channels
(pen coloours) of the ssoftware plo
otter will be
e entered intto the proce
ess event
list. The selection
s of measurand ds can only be changedd under "Prrocess
Graphics" "Measurred Values"".
NO
OTE
Since the
e process evvent list is written
w sequ
uentially, a cchange of th
he
measuran nd selection
n will be impplemented in the list onnly as of the
e point of
time when the chang ge was perfformed (not retrospecti vely as of the start of
the record
ding processs).
NO
OTE
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Maintenaance: The p point "Mainttenance" (f) provides aaccess to

maintenance-relevan nt data of th
he freeze-drryer. It is onnly available
e if a
freeze-dry
yer is conne
ected and switched
s on.
Fig. 97- "Ex

xtras" "Mainttenance" - "W
Working Hours""
Operating g hours: Un der "Workinng Hours" (ffI), the total number of operating
hours and d the start-u
up cycles off the various
s componennts of the frreeze-dryer
are listed.
Fig. 98 - "Ex
xtras" "Main
ntenance" - "M
Maintenance"
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Maintenance: The m maintenance e data of the

e freeze-dryyer (maintennance
interval, date
d of the l ast mainten nance, nummber of operrating hourss since the
last mainttenance) arre displayed d in the upper area of tthe window under
"Maintena ance" (fII). A
After the ma h been coompleted, the button
aintenance has
t current date as the
"Reset" (i) must be cclicked in orrder to use the e date of
the last maintenance
m e and to resset the numbber of operaating hours since the
last mainttenance to "0".
The area below show ws the oil chhange data of the vacuuum pump (oil( change
intervals, number of operating hours
h since the last oil change). Since the oil
change in nterval depe ends strong gly on the op
perating connditions of the
t pump,
it can be adjusted fre eely by pres ssing the bu
utton (iii). W
When the specified
number of o operating hours is re eached, a message inddicating that an oil
change is s due will be o change, tthe corresponding
e displayed. After the oil
button "RReset" (ii) mu ust be clicked in order to reset thee number off operating
hours since the last o oil change to
t "0".
Fig. 99 - "Ex
xtras" "Main
ntenance" "Prrint"
Printing: Apart
A from tthe actual printing
p of th
he maintenaance-relevaant data,
the buttonn "Print" (fIII) also offers
s a correspoonding printt preview as
s well as
the output in PDF un nder "Previe ew" - "Save As".
The butto o" (2) in the lower area of the winddow works in the same
on "Unit Info
way as thhe button off the same name
n underr the schemmatic systemm diagram.
It can be used to acccess information conce erning the frreeze-dryerr (see
chapter 2.1.3
2 - "Visuualisation, alarms, and system i nformation n "). In this
case heree, however, no running g process re
ecording proocess is nec cessary.
Instead, the
t freeze-d dryer only needs to be connected and switche ed on.
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3.5
5 Vapour p
pressure cu
urve for ice
e
Pos: 88 /200 Christ/400 Software-Bedienungsanleitungen (STANDARDMODULE)/LPCplus Rev 1.0/070 Verwaltunggsfunktionen der Software/070-0050 Dampfdruckkurve ber Eis @ 13\mod_1346910131047_68.docx @ 71937 @ 2 @ 1
3.5 V
Vapour prressure curve
c for ice
The buttoon "Steam PPressure" (N
N) on the toolbar can bbe used any
y time in
order to call
c up the vvapour pressure curve for ice (subblimation pre
essure
gether with the associa
curve) tog ated value table.
Fig. 100 Vapour

V pressu
ure curve for ic
ce with the associated valuee table
2012-10
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5
al German lan
nguage instru
SCADA Softw
ware LPCpluss
3 Adminis
stration fun
nctions of the
t softwarre

=== Ende der Liste fr Textmarke Inhalt ===
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nstructions Rev.
R 1.0 wae
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SCADA Softw
ware LPCpluss
Index
x
4 Ind
dex
Access rights ......................................... 84, 8 85 Desorption
D (process phaase) ....................... 67 7
Acknowled dgement (alarms) ........................ 1 16 Determinatio
D on of the dryying end (prressure
Adding a n note (processs events) .................. 2 27 increase te est) ........................................... 666
Additional set values (freeze-dryiing program m) Determinatio
D on of the endd of the dry ying
................................................................ 4
49 process (D Delta-Tproductt test)...................... 65 5
Administra ation functio ons of the so oftware ..... 8 81 Determinatio
D on of the endd of the dry ying
process (p pressure inccrease test) ............ 36 6
Aeration m medium (pre eselection) ............ 32, 5 55
Determinatio
D on of the ressidual moistture
Aeration, a automatic ..................................... 5 51
content (w weighing sysstem) ...................... 38 8
Aeration, m manual ......................................... 7 73
Diagram
D (vis
sualisation w window) .................. 15 5
Aeration, sstoppering, storage ...................... 5 51
Documentati
D on ............................................ 877
Alarm indiccator ............................................ 1 16
Drying
D end determinatio
d on (Delta-Tproductp test)
Alarms ......................................................... 1 16 ................................................................. 65
5
Audit trail ...................................................... . 6 Drying
D end determinatio
d on (pressure e increase
Authentica ation .............................................. . 6 test) .......................................................... 666
Backfilling .................................................... 5 53 Drying
D phase es in detail ................................ 59 9
Backup ......................................................... . 6 Drying
D proce ess ............................................ 34 4
Backup (se ettings) ...................................... 10 00 Drying
D vacuu um (recomm mendation) ............. 94 4
Backup file es................................................. 9 98 Electronic da ata recordinng.............................. 6
Batch data a ................................................... 1
12 Enabled/disa abled (user account) ................ 84 4
Batch data a input fieldss (names) ................ 10 00 Executing a freeze-dryinng program/recipe . 68 8
Chamber vvacuum mo onitoring ...................... 6 63 Export (raw processp datta) .................... 23, 90 0
Changing a password d ................................. 881 Extras .......................................................... 99 9
Channel asssignment (process ( diaagram)20, 8 89 FDA ............................................................... 6
CHRIST su upport.......................................... 9 95 Field names (batch dataa input fields) ....... 100 0
Company llogo ........................................... 10 00 File extensio on (record fi les) ........................ 98 8
Company n name ......................................... 10 00 Freeze-drying phases inn detail ................... 59 9
Conformityy with 21 CF FR Part 11 .................. . 6 Freeze-drying process................................. 34 4
Creating/editing a use er account) ................. 8 83 Freeze-drying program (template) .............. 44 4
Creating/m modifying a freeze-dryin
f ng Freeze-drying program//recipe
program m/recipe ........................................ 4 41 (creating/m modifying) ................................. 41
Crystallisation state monitoring
m (pproduct) ... 6 61, Freezing (pro ocess phasse)........................... 60 0
65 Freezing point, automattic determin nation .... 94 4
Cyclic even nts ....................................... 27, 10 02 Fundamenta al principles ................................ 7
Data backu up ............................................ 6, 9 97 Gas
G injection n (vacuum ccontrol) ............. 33, 56 6
Data backu up (settingss) .............................. 10 00 General
G information ....................................... 5
Data exporrt (raw proccess data)............. 23, 9 90 Hardware
H alaarms ......................................... 16 6
Data integrrity ........................................... 6, 1 13 History
H (freez ze-drying p rogram) ................. 57 7
Data recorrding, electrronic ............................ . 6 In
njection (vac cuum controol) .................... 33, 56 6
Date inform mation (proccess events s) .............. 227 In
ntroduction.................................................... 5
Defrosting .................................................... 7 75 Laanguage .................................................... 31
Delta-Tproduuct test .................................... 60, 6 65 Leeak test ...................................................... 77 7
Delta-Tshelff test....................................... 60, 6 64 Looading temperature ................................... 59 9
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Index
Log-in .................................................... 11, 8 81 Password

P length .......................................... 82
2
Log-in atte empts ........................................... 8 82 Password
P tim
mer............................................ 82
2
Logo (com mpany) ........................................ 10 00 Password,
P changing .................................... 81
Log-out ........................................................ 1 12 PDF
P output (process
( diaagram) ................... 23 3
LPCplus scrreen .............................................. . 7 PDF
P output (process
( doocumentatio on)......... 90 0
LyoControl calculation n................................. 994 PDF
P output (process
( evvents)...................... 27 7
LyoControl scale (process diagra am) ........... 2 21 PDF
P output (program/re
( ecipe data).............. 57 7
LyoControl-RX test................................ 61, 6 65 Performing
P a leak test ................................. 77 7
Main drying (process phase)....................... 6 62 Precooling
P (ffreeze-dryinng program section) 46 6
Maintenance ............................................. 10 03 Precooling
P (ffreeze-dryinng section).............. 59 9
Manual mo ode (freeze--drying) ...................... 3 39 Prefrozen
P product ........................................ 599
Measurem ment value assignment
a (process Preselection
P (operating mode) ................... 29 9
diagram) ............................................ 20, 8 89 Pressure
P conntrol valve ........................... 33, 56 6
Media drain ................................................. 7 79 Pressure
P inc
crease test ((determination of the
Messages .................................................... 1 16 end of the drying proccess) ...................... 36 6
Mode chan nge (Manua al Program m) ............. 4 40 Pressure
P inc
crease test ((drying end
Mode presselection....................................... 2 29 determinattion) .......................................... 66 6
Monitoring (chamber vacuum) v .................... 6
63 Pressure
P scaale (processs diagram).............. 21
Monitoring (product crrystallisation state) ... 6 61, Preview
P (pro ocess diagraam) ......................... 23 3
65 Preview
P (pro ocess docum mentation) .............. 90 0
Monitoring (product re esistance) ............ 61, 6 65 Preview
P (pro ocess events ts) ........................... 277
Monitoring (product te emperature)) ......... 60, 6 65 Preview
P (pro ogram/recipee data) ................... 57 7
Monitoring (residual product p mois sture) ....... 5 54 Print
P (proces ss events) ................................. 27 7
Monitoring (shelf temp perature) .............. 60, 6 64 Printing
P (proc cess diagraam) ......................... 23 3
Multi-cham mber mode ................................... 3 35 Printing
P (proc cess docum mentation)............... 90 0
Name (battch data inp put fields) .................. 10 00 Printing
P (prog gram/recipee data).................... 57 7
Name (com mpany) ...................................... 10 00 Process
P (free eze-drying ................................ 34 4
Name (free eze-drying program)
p .................... 5
56 Process
P alarrms............................................ 166
Name (unit) ................................................. 9 99 Process
P analysis ......................................... 95 5
Note (proccess events) ................................. 2 27 Process
P control............................................ 299
Oil change e interval (va acuum pum mp) .......... 10 03 Process
P development .................................. 39 9
Operating functions ..................................... 2 29 Process
P diag gram ................................... 19, 93 3
Operating hours ........................................ 10 03 Process
P events ............................................ 266
Operating mode chan nge (Manual Program m) Process
P grap phics ......................................... 19
9
................................................................ 4
40 Process
P mes ssages ...................................... 16 6
Operating mode prese election ...................... 2 29 Process
P mon nitoring........................................ 7
Operating temperaturre (vacuum pump) ...... 5 50 Process
P reco ord file................................. 13, 87 7
Parameterrs, general (freeze-dryi
( ng program m) Process
P reco ording (startt) ............................ 11
................................................................ 4
49
Process
P reco ording (stopp) ............................ 13 3
Parameterrs, section-sspecific (free eze-drying
Product
P crystallisation sstate monito oring 61, 65 5
program m) .................................................. 448
Product
P mois sture monitooring ...................... 54 4
Partial she elf loading............................... 52, 7 73
Product
P resis stance monnitoring .............. 61, 65 5
Password .............................................. 12, 8 84
Product
P temp perature moonitoring ........... 60, 65 5
Password expiry.......................................... 8 82
Program
P loca ations (maxximum number) ...... 46 6
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Index
x
Program m mode (freeze e-drying) .................... 4 41 Start (proces ss executionn) ........................... 29 9

Program sections (ma aximum num mber) ........ 4 46 Start parame eters (freezee-drying pro ogram) .. 46 6
Program/re ecipe (freezze-drying, Start section ................................................ 69 9
creating//modifying) .................................. 4 41 Start temperature ........................................ 69 9
Qualificatio on ................................................. . 6 Start time ..................................................... 69 9
Ramp calcculation (vaccuum, shelff Start vacuum m ............................................... 69 9
tempera ature) ............................................ 4 47
Status bar ...................................................... 7
Reading off measurem ment values (process
Stop (proces ss executionn)............................ 29 9
diagram) .................................................. 2 22
Stoppering of o the produuct, automattic ......... 51
Recipe/pro ogram (freezze-drying,
creating//modifying) .................................. 4 41 Stoppering of o the produuct, manual ............. 73 3
Record file e ............................................. 13, 8 87 Storage loca ations (maxiimum numb ber) ....... 46 6
Residual m moisture dettermination (weighing Storage of th he product, automatic .............. 51
system) .................................................... 3 38 Sublimation (process phhase) ...................... 62 2
Residual m moisture mo onitoring (prroduct) ...... 5 54 Sublimation pressure cuurve (vapou ur pressure
Resistance e monitoring g (product) ........... 61, 6 65 curve for ic ce) .......................................... 105 5
Resistance e scale (pro ocess diagra am) ........... 2 21 Support ........................................................ 95 5
Rights .................................................... 84, 8 85 Switching to the next seection after precooling
(drying pro ogram) ...................................... 72 2
Run (butto on) ................................................ 2 29
Switch-over (Manual - P Program) ................ 40 0
Safety presssure ........................................... 6 63
System control............................................... 7
Safety setttings ............................................ 8 81
System of rig ghts, hierarcchic .......................... 6
Scaling (prrocess diagram) .......................... 2 21
System statu us ................................................ 7
Schematicc system dia agram (visualisation
window)) ................................................... 1 15 Temperature e control (shhelves,
only preco ooling sectioon) .......................... 59 9
Schematicc system dia agram (visualisation) .. 1 12
Temperature e control (shhelves, othe er sections)
Secondaryy drying (pro ocess phase e) ............. 667
........................................................... 60, 62 2
Section (prrocess diag gram) .......................... 2 22
Temperature e course (shhelves, temperature
Sections (m maximum number) n ...................... 4
46 ramps)...................................................... 47 7
Service life e (vacuum pump) p ........................ 5
50 Temperature e monitoringg (product)........ 60, 65 5
Set value ccourse (vaccuum, shelf temperaturre) Temperature e monitoringg (shelf) ............ 60, 64 4
................................................................ 4
47
Temperature e scale (pro cess diagra am) ....... 21
Set valuess, additional (freeze-dry ying
Template (fre eeze-dryingg program).............. 44 4
program m) .................................................. 449
Time range (process
( diaagram) ................... 21
Set valuess, section-sp pecific (freeze-drying
program m) .................................................. 448 Time scale (process diaagram) .................... 21
Settings, g general ......................................... 9 99 Toolbar .......................................................... 7
Shelf preco ooling .......................................... 5 59 Unit
U info ..................................................... 104 4
Shelf temp perature con ntrol Unit
U Info ....................................................... 18 8
(only pre ecooling secction) ......................... 5 59 Unit
U name .................................................... 99 9
Shelf temp perature con ntrol (other sections) . 6 60, User
U account (creating/eediting) .................. 83 3
62 User
U accounts ............................................. 81
Shelf temp perature cou urse (tempe erature User
U adminis stration ..................................... 81
ramps) ..................................................... 4 47 User
U ID .................................................. 12, 84 4
Shelf temp perature mo onitoring ................ 60, 6 64 User
U level .................................................... 84 4
Spacers fo or partially lo oaded shelv ves ..... 52, 7 73 User
U levels................................................... 85 5
Standby (b button) ......................................... 2 29
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SCADA Softw
ware LPCpluss
Index
User log-in
n............................................. 11, 8 81 Vapour
V press sure curve ffor ice (sub blimation
User log-out ................................................ 112 pressure curve)
c ...................................... 105 5
User name e .................................................. 8
84 Visualisation
V (schematicc system diagram) . 12 2
Vacuum co ontrol ............................... 33, 56, 6 62 Visualisation
V window (scchematic sy ystem
diagram)................................................... 15 5
Vacuum co ourse (vacu uum ramps)) ................ 4 47
Warm-up
W me (vacuum pump) ................... 50
tim 0
Vacuum m monitoring (cchamber) .................... 6 63
Weighing
W sysstem (deterrmination off the
Vacuum pu ump (oil cha ange interva al) .......... 10 03
residual moisture
m conntent) ...................... 38 8
Vacuum sccale (processs diagram)) ............... 2 21
Weighing
W sysstem CWS--40 ......................... 54 4
Vacuum, sset value forr main dryin ng
Work
W area ...................................................... 7
(recommmendation) ................................... 9 94
Zoom (proce ess diagram m) ............................ 22 2
plays ............................................. 1
Value disp 16
2012-10
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R 1.0 wae
e

BA LPCplus 2012-10 1-0 en

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Operating Manual

Tel.: 9 (0) 5522 / 5007-0

Pos: 5 /010 Universalmodule/ Seitenwechsel @ 0\mod_1202116244312_0.doccx @ 105 @ @ 1

Pos: 8 /010 Universalmodule/ Seitenwechsel @ 0\mod_1202116244312_0.doccx @ 105 @ @ 1

2.1 Fundamental prin

2 System control and process monitoring

(d) Brief actuattion:

2 System control and process monitoring

(j) Alarm indiccator and bu

The "statu us bar" at th

(a) System staatus:

Pos: 15 /010 Universalmodule/ Seitenwechsel @ 0\mod_1202116244312_0.doocx @ 105 @ @ 1

2 System control and process monitoring

Fig. 7 Callling up the B

2 System control and process monitoring

Pos: 18 /010 Universalmodule/ Seitenwechsel @ 0\mod_1202116244312_0.doocx @ 105 @ @ 1

(a) Process meessage in a pop-up win ndow. At thee same time, a

2 System control and process monitoring

The comp ponents and d units of th

Regardless of the wiindow that is currently active or shhown in the

(a) Date and ti me of the la

Fig. 11 - "Alarm List" - "In

2 System control and process monitoring

The buttoon "Unit Info

Pos: 21 /010 Universalmodule/ Seitenwechsel @ 0\mod_1202116244312_0.doocx @ 105 @ @ 1

2 System control and process monitoring

Measurement value e assignme ent: Via "Me

Fig. 14 - "Process Graph

2 System control and process monitoring

Fig. 16 - "Process Graph

Reading of measurrement valu ues: In orde er to read a measurem ment value

It may be necessaryy to deactiva

The value es of the meeasurands that

2 System control and process monitoring

e button "Prrint" (6) can be used to print basedd on the pre

Pos: 24 /010 Universalmodule/ Seitenwechsel @ 0\mod_1202116244312_0.doocx @ 105 @ @ 1

2 System control and process monitoring

Fig. 22 - "Process Eventss"

Date infoormation: T The button "Date

Adding a note: The e button "No

Cyclic evvents: In ad ddition to the graphical output of thhe values of

Printing parameters s: The butto

Fig. 23 - "Process Eventss" - "Printing Parameters"

2 System control and process monitoring

Clicking the buttons (ii) to (vi) ac

Printing of process s events: Apart from th he printing oof the proce

Fig. 24 - "Process Eventss" - "Print"

Pos: 27 /010 Universalmodule/ Seitenwechsel @ 0\mod_1202116244312_0.doocx @ 105 @ @ 1

2 System control and process monitoring

In the "Ruun" status, ccertain modde changes (e.g. from ""Program" to t

Printing of set valu es: Apart frrom the prin

Fig. 26 - "Process Contro

Options: The "Optio ons" button (3) can be used

Fig. 27 - "Process Contro

Language e: After the button "Lan

Fig. 28 - "Process Contro

2 System control and process monitoring

Fig. 29 - "Process Contro

Inert gas: elects the media connection "Inert Gas".

Gas injecction: If the ffreeze-drye

Fig. 30 - "Process Contro

Off: The g as injectionn is deactiva

Standard: Vacuuum control is ensured by b combineed evacuatio on and