Choose the most appropriate answer.

1. In case of unconscious patient, the preferred dosage form is:

a) Oral tablet
b) Soft gelatin capsule
c) Rectal suppository
d) Ointment

2. Bougies are
a) Compressed into conical shapes
b) Intended for both sexes
c) Prepared with PEG

3. All of the following about aurnaria are correct except

a) Ear cones
b) Very rarely used
c) Prepared from glycero gelatin base only
d) Prepared in urethral suppository molds

4. The absorption of salicylic a from rectal supp can be increased at PH

a) 4
b) 7
c) 9
d) a &b

5. For drugs administered high in the rectum, the following statements are true except:
a) Drugs drained by superior hemorrhoid vein
b) They are carried by rectal veins directly to liver
c) They are not subjected to metabolism
d) Their uptake is influenced by the rectal PH 6.8

6. Hepatic 1st pass effect of drugs could be reduced by rectal administration as:
a) Superior hemorrhoid vein joins directly to inferior vena cava
b) Inferior and middle hemorrhoid veins join to mesenteric vein
c) Both of the above
d) Non of the above

1
7. The rate limiting step in drug absorption from suppository is
a) the release of the drug from the base
b) the dissolution rate of the drug in body fluids
c) neither a nor b

8. The rate of drug diffusion to the site of rectal absorption depends on all of the
following except
a) Nature of medicament
b) Chemical nature of solids present
c) PH of rectal fluids

9. An ideal suppository base should have

a) Acid value >2
b) Iodine value < 7
c) Low water number
d) All of the above

10. All the following about the disadvantages of the theobroma oil are correct except
a) Rancidity
b) High reactivity
c) Adherence to mold
d) Too low softening point

11.The Beta stable form of cacao butter melts at

a) 15 C
b) 20 C
c) 28 C
d) Non of these

12.All of the following about Witepsol H15 are correct except:

a) Contains glyceryl mono stearate.
b) Alternative base to cacao butter
c) Melts at 32-34 C
d) Doesn't contract sufficiently.

2
13.Glyceryl mono stearate:
a) W/O emulsifier
b) O/W emulsifier
c) Increase water number
d) a & c
e) b & c

14.Hexane-1,2,6- triol is a
a) Viscosity modifier
b) Preservative
c) Plasticizer
d) Thickening agent.

15.Macrogol suppository can be prepared by:

a) Molding
b) Cold compression
c) Hand rolling
d) a & b

16.All the following about PEG base containing 96% PEG 1000 & 4% PEG 400 are true
except
a) Rapid disintegration
b) Need refrigeration
c) Used for water-soluble, PEG-insoluble drugs

17.The following bases are recommended for preparing pessaries except

a) Carbowax
b) Glycerogelatin
c) Cacao butter

18.Which of the following bases is rarely used for preparing medicated rectal
suppository
a) PEG
b) Cacao butter

3
c) Wecobee
d) Glycero gelatin

19.All the following can be added to cope hot weather except

a) Bees wax
b) Additional gelatin
c) Wool fat
d) High M.wt PEG

20.Macrogol bases are incompatible with

a) Salicylic acid
b) Aspirin
c) Quaternary ammonium compound
d) All the above

21.Nonoxyneol-9
a) Restores vaginal mucosa to its normal state
b) Used for vaginal infection
c) Is spermicidal
d) a , b & c

22.all the following about bioadhesive vaginal tablets are correct except
a) used for topical & systemic effect
b) hydrate after insertion
c) require more frequent dosing
d) Reduce the rate of drug release.

23.A suppository is generally intended for use in

(a) Rectum (b) Vagina (c) Urethra (d) All the above

24.Vaginal suppositories also called as

(a) Pessaries (b) Simple suppositories (c) Bougies (d) None

25.Weight of rectal suppository for adults is

(a) 1 g (b) 2 g (c) 5 g (d) None

26.Weight of rectal suppository for children is

4
 (a) 1 g (b) 2 g (c) 5 g (d) None

27.Urethral suppositories also called as

(a) Pessaries (b) Bougies (c) Both (d) None

28.Urethral suppositories having which shape

(a) Oviform shape (b) Torpedo shape (c) Pencil shape (d) None

29.Weight of urethral suppository for males & females respectively

(a) 4 & 2 (b) 2 & 4 (c) 4 & 6 (d) 6 & 4

30.Shape of vaginal suppositories is

(a) Oviform shape (b) Torpedo shape (c) Pencil shape (d) None

31.Rectal suppositories mainly used for the treatment of

(a) Constipation (b) Hemorrhoids (c) Both (d) None

32.The number of milligrams of KOH required neutralizing free acids & saponify the
esters contained in 1 g of fat is known as
(a) Iodine value (b) Saponification value (c) Water number (d) Acid value

33.The number of grams of iodine that reacts with 100 g of fat is known as
(a) Iodine value (b) Saponification value (c) Water number (d) Acid value

34.The number of milligrams of KOH required neutralizing free acids in 1 g of fat is

known as
( a) Iodine value (b) Saponification value (c) Hydroxil value (d) Acid value

35.Which of the following method is used to manufacture suppositories

(a) Hand molding (b) Compression molding (c) Pour molding (d) All the above

36.Cocoa butter available in following forms

(a) -form (b) -form (c) -form (d) All

37.The solidification point of cocoa butter lies between

(a) 12 13o (b) 20 30o (c) 5 10o (d) None

38.Which of the following method is simple & oldest method of preparation of

suppositories?
(a) Hand molding (b) Compression molding (c) Pour molding (d) All the above

5
39.Most commonly used method for producing suppositories on both a small & large
scale is
(a) Hand molding

(b) Compression molding (c) Pour molding (d) All the above

40.Rancidity generally results from

(a) Auto oxidation (b) Decomposition of unsaturated fats (c) Both
(d) None

41.Which of the following is not antioxidant?

(a) BHT (b) BHA (c) Tocopherol (d) Theobroma oil

42.Suppositories are generally evaluated by

(a) Melting range test (b) Breaking test (c) Liquefaction (d) All the above