Noncompartmental Analysis

(Statistical Moment Theory)

Mean Residence Time

AUMC
MRT (for any route of administration)
AUC

1
MRTiv
kd
1

t 12 0.693 MRTi.v.

MRT = time for 63.2% of an IV dose to be eliminated.

1
= time required for concentration to fall to of original (i.e., 36.8% remaining)
e

Determination of MRT:

MRT is a function of how drug is administered

MRTNoninstantaneous administration MRTInstantaneous administration

 AUMC
MRTi.v after an i.v. dose
AUC

MRTi.v can be estimated following other modes of administration as follows:

I.V. Infusion:

MRTinf MRTiv
2

Oral dose (p.o.):

1
MRTp.o. MRTiv
ka
MRTi.v MAT
1 1

ka

1
MAT = mean absorption time =
ka

Generally

MAT MRTni MRTi.v.

MRTni = noninstantaneous mean residence time

t1 abs
0.693 MAT
2
 Apparent volume of distribution at steady state

For I.V. bolus:

Vss CL MRT

Di.v.
CL
AUC

Di.v. AUMC
Vss
AUC AUC
Di.v. AUMC

AUC
2

For I.V. Infusion:

R o AUMC R o 2
Vss
AUC
2
2AUC

Infused Dose AUMC Infused Dose
AUC
2
2AUC

Infused Dose R o
Where is the infusion time.

For P.O.:

FD AUMC FD
Vss
AUC k a AUC
2

I.V. Bolus + I.V. Infusion:

Vss
R o Di.v. AUMC R o 2
AUC
2
2AUC