-prospective ethically designed investigationin human subjects to objectively discover/verify/

compare the results of two or more therapeutic measures (drugs)

- Conducted in to determine

A) healthy volunteers

1)pharmacokinetic characteristics

2) tolerability

3)Safety

4) efficacy of a) hypohlycemics

B) hypnotics

C) diuretics

B) volunteer patients. Efficacy of drugs ( antiepileptic,antipsychotic, antinflammatory,antiTB)