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BUNDLES

TO BE COMPLETED TO BE COMPLETED
WITHIN 3 HOURS: WITHIN 6 HOURS:
1) Measure lactate level. 5) Apply vasopressors (for
2) Obtain blood cultures prior to hypotension that does not respond
administration of antibiotics. to initial fluid resuscitation) to
maintain a mean arterial pressure
3) Administer broad spectrum antibiotics. (MAP) 65 mm Hg.
4) Administer 30 ml/kg crystalloid for 6) In the event of persistent
hypotension or lactate 4mmol/L. hypotension after initial fluid
Time of presentation is defined as administration (MAP < 65 mm Hg)
the time of triage in the emergency or if initial lactate was 4 mmol/L,
department or, if presenting from another re-assess volume status and
care venue, from the earliest chart tissue perfusion and document
annotation consistent with all elements of findings according to Table 1.
severe sepsis or septic shock ascertained 7. Re-measure lactate if initial lactate
through chart review. elevated.

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BUNDLES

TABLE 1
DOCUMENT REASSESSMENT OF VOLUME STATUS AND
TISSUE PERFUSION WITH:

EITHER:
Repeat focused exam (after initial fluid resuscitation) including vital
signs, cardiopulmonary, capillary refill, pulse, and skin findings.

OR TWO OF THE FOLLOWING:


Measure CVP.
Measure ScvO2.
Perform bedside cardiovascular ultrasound.
Perform dynamic assessment of fluid responsiveness with passive leg
raise or fluid challenge.

@2016 Society of Critical Care Medicine, European Society of Intensive Care Medicine.
www.survivingsepsis.org

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