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Lower Genitourinary Injuries

51
Donald Hannoun and Charles D. Best

51.1 Acute Scrotal and Testis Injuries or external inguinal ring) by an expanding scrotal hematoma.
As always, you should always maintain a high index of sus-
Trauma to the external genitalia can be separated into blunt picion for urethral injury, especially with penetrating trauma.
versus penetrating injury. Differentiating between these two Inability to void and an expanding scrotum with or without
mechanisms will have the immediate benefit of facilitating scrotal ecchymosis may suggest urinary extravasation and
patient care in the trauma suite. Noting the mechanism of should proceed to work-up with a retrograde urethrogram
injury will also help you determine the likelihood of need for (RUG) or gentle passage of a urethral catheter.
eventual surgery, the potential length of convalescence, and During the initial evaluation and work-up of scrotal or
the possibility of injury to the contralateral testis. Particularly testicular injury, you should also take into account the
with penetrating injuries, you should have a high index of patients clinical status and hemodynamic stability. Lower
suspicion of injury to the contralateral testicle. It may also genitourinary injuries are not often life-threatening. If the
assist in the prediction of future fertility. patient is clinically stable for transfer, a scrotal ultrasound
Several features of the scrotum and testis make these can help identify the injury (i.e., hypoechoic testicular
structures relatively resilient to trauma. The mobility of the lesions suggest hematoceles, disruption of the tunica albu-
scrotum allows displacement from an inciting injury, and the ginea suggests rupture, lack of blood flow suggests torsion,
cremasteric reflex helps move the testis superiorly upon etc.). Facilitating these diagnostic studies early in a clinically
scrotal contact. Additionally, the testis has a relatively tough stable patient allows for early diagnosis.
tunica albuginea, which can help contain a developing hema- If the patient is physiologically unstable, then a portable
toma and prevent seminiferous tubule extrusion. study can be performed at the bedside in the intensive care
The vast majority (between 75 and 85 %) of scrotal/tes- setting. Unfortunately, scrotal ultrasounds can have a high
ticular injuries result from blunt trauma and are typically false-negative rate even in the presence of an experienced
unilateral. Penetrating injuries to the scrotum are typically examiner. For this reason, if the index of suspicion for tes-
gunshot or stab wounds and are more likely to result in bilat- ticular injury is high, which is often the case with penetrating
eral testicular injury (30 %), while only 1.5 % of blunt scrotal injuries of the scrotum, explore the patient if noninvasive
injuries are bilateral. A detailed history and physical exam diagnostic testing is unavailable or unsafe. Realistically, if
will usually indicate the likely mechanism and underlying the patient is unstable, the scrotal or testicular injury is low
injury, often dictating further workup and management. We on the list of priorities.
will often acquire a testicular ultrasound to determine The management of scrotal/testicular injury will also
whether the testicle itself is injured and assess the contralat- often depend on the overall clinical status of the patient. In
eral testicle as well. Basic palpation is also a simple but very the face of multiple medical or surgical comorbidities, the
helpful aspect of the initial physical exam. Inability to pal- patient may not be stable enough for transfer to the operative
pate the testis may suggest the presence of testicular rupture suite for intervention. Communication between the primary
or testicular displacement (often back towards the superficial team and consulting services should dictate the appropriate
plan of action best suited for the patients overall
improvement.
D. Hannoun (*) C.D. Best In the case of multiple injuries requiring exploration, sur-
Department of Urology and Surgery, USC Institute of Urology,
USC Keck School of Medicine, LAC + USC County Medical
gical intervention for scrotal or testicular injury should be as
Center, Los Angeles, CA, USA rapid as clinically possible. Even when the involved testicle
e-mail: dhannoun@usc.edu; cbest@usc.edu is an isolated injury, we recommend minimizing any delay in

Springer-Verlag Berlin Heidelberg 2017 397


G.C. Velmahos et al. (eds.), Penetrating Trauma, DOI 10.1007/978-3-662-49859-0_51
398 D. Hannoun and C.D. Best

repair. Several studies have shown that prompt surgical you can close the scrotal skin primarily at the time of surgery
intervention with testicular rupture, especially if performed with a running chromic suture as previously described after
within 72 h of the injury, will often prevent superinfection of copious irrigation. Even with up to 60 % of the scrotal skin
the scrotal hematoma, lessen the length of convalescence, lost, the skin can still often be closed primarily. Larger
decrease the potential for chronic pain, and may even amounts of genital skin loss will necessitate wet-to-dry
improve fertility. Gross et al. reported an improvement in dressings postoperatively with delayed grafting. As always,
testicular salvage rate from 32 to 80 % if surgical exploration scrotal avulsion injuries should always be assessed for under-
was performed within 3 days of the inciting injury, and lying testicular injury, and you should manage them
Jeffrey et al. and Lupetin et al. went on to show testicular appropriately.
salvage rates of 90 % when surgical intervention was per-
formed within 72 h.
Surgical intervention is usually performed transscrotally, 51.2 Penile Injury
with the incision made down the midline raphe of the scro-
tum to allow bilateral testicular assessment and manage- Penetrating penile injuries are relatively rare and usually
ment. Carry down the dissection through the dartos layer to take the form of gunshot and stab wounds. However, one can
the tunica vaginalis, which may or may not be intact. Bring also encounter penile avulsion injuries from motor-vehicle
the testis, epididymis, and distal spermatic cord onto the field or bicycle accidents as well as the occasional self-mutilating
and examine closely for any evidence of injury. If the testicu- injuries and animal or human bites. Despite the abovemen-
lar injury is severe and salvage is unlikely, then proceed to an tioned multiple possible mechanisms of penile trauma, sig-
orchiectomy. Tunica albuginea violation should be apparent nificant penile injuries remain rare secondary to the tough
once the testis is delivered from the tunica vaginalis. With tunica albuginea covering of the penis. Penetrating penile
tunica albuginea disruption, you should attempt to debride injuries may result in a tear of the tunica albuginea encasing
any unviable seminiferous tubule tissue. The presence of the corpora cavernosa, which allows extravasation of blood
active bleeding is a sign that remaining tissue is viable. If from the corpora into the penile shaft. Because of the pene-
there is any question about testicular viability, an intraopera- trating nature of the injury, blood will exit out of the wound
tive Doppler study should be performed to guide further site, typically not extending along fascial lines as with penile
intervention. Repair the defect with a running 4-0 suture, fracture. The penis may swell and have some ecchymosis,
prolene being the suture of choice at our institution but you usually do not see the so-called eggplant penis
(Fig. 51.1b). Damage to the vas deferens should be addressed appearance in penetrating injuries.
with ligation and delayed reconstruction. Vasovasostomy is With penetrating injuries to the penis, you should always
not a trivial procedure and should not be done in an acute suspect compromise of the tunica albuginea. The mechanism
setting. alone will almost always mandate surgical exploration.
You should always anticipate potential postsurgical com- However, if the diagnosis is in question, further imaging
plications and should pay strict attention to hemostasis prior studies are available, although with highly variable results
to scrotal closure. In the presence of persistent bleeding or an and inter-interpreter variations. Cavernosograms can be per-
underlying coagulopathy, place a quarter inch Penrose drain formed with injection of contrast material into the corpus
in the inferior/dependent portion of the scrotum to prevent cavernosum, with serial radiographs taken to identify the site
accumulation of a postoperative hematoma. The dartos clo- of extravasation. The false-negative rate is unfortunately
sure is carried out with a running 4-0 Vicryl stitch and the very high with this modality, as the tear can be too small to
scrotal skin closure with a running or interrupted 3-0 chro- see, and often the presence of a clot at the tear site will mask
mic suture with locking of each suture. Leave the Penrose the extravasation. False-positive studies result when the
drain to gravity drainage into a Kerlix roll, which is held physiologic egress of contrast through emissary veins is mis-
closely to the scrotum with a scrotal support for comfort and interpreted as extravasation. Similarly, penile ultrasound
elevation. Remove the drain 2448 h postoperatively. cannot consistently identify the site of tear unless in the
Antibiotics are routinely recommended for 710 days post- hands of a very skilled examiner. MRI in the T1 phase,
operatively to prevent abscess formation or infections along although more sensitive than cavernosography and ultra-
the incision line. Apply antibiotic ointment to the suture line sound, has a limited role secondary to the time required, the
three times a day for 710 days. difficulty with transportation, and the frequent clinical insta-
Genital avulsion injuries can be considered another form bility of the patient. These studies have no role in significant
of penetrating trauma to the scrotum. These injuries are sus- penetrating injuries. They have value in cases of penile frac-
tained during rapid deceleration of the body and concomitant ture, when there is an atypical presentation. You should
shearing mechanism against the scrotum and perineum, lead- always suspect underlying urethral injury with any penetrat-
ing to loss of the scrotal skin. In the majority of situations, ing penile trauma. If the patient has not spontaneously voided
51 Lower Genitourinary Injuries 399

Fig. 51.1 (a) Often with


penetrating injuries, the testicular a
injury is obvious, as is seen here
where the tunica albuginea has
been disrupted (arrow). (b)
Repair the defect with a running
4-0 suture, prolene being the
suture of choice at our institution

clear urine or has hematuria, either gross or microscopic, an ease of passage into the bladder. You can then use this cath-
RUG should be performed prior to surgical exploration to eter for the retrograde instillation of saline/dye during the
assess for urethral injury. procedure to evaluate for any urethral discontinuity. First
Tunical violation injuries of the penis should ideally be make a circumferential (degloving) incision, which allows
surgically corrected within 36 h of sustaining the injury. access to the length of the corpora cavernosa and spongio-
Exploration is mandatory to prevent the sequelae of infected sum. Place a tourniquet at the base of the penis as it can aid
hematomas, impotence, and penile curvature that may result with hemostasis and dissection (Fig. 51.2a). Carry out evacu-
without prompt operative intervention. Again, other more ation of the hematoma, and localize the site of tunical viola-
life-threatening injuries should be identified and addressed tion after you dissect free Bucks fascia. Once you have
first. identified the defect, debride the wound edges and do copi-
Once the patient has reached the operative suite, the ous irrigation, particularly important with gunshot injuries or
appropriate area is prepped and draped in standard sterile bites. Carry on primary closure of the defect with 4-0 prolene
fashion. Insert a urethral catheter at the beginning to ensure suture in a figure-of-eight fashion. We prefer to do this with
400 D. Hannoun and C.D. Best

Fig. 51.2 (a) Place a tourniquet


at the base of the penis as it can a
aid with hemostasis and
dissection. (b) Debride the
wound edges and do copious
irrigation, particularly important
with gunshot injuries or bites.
Carry on primary closure of the
defect with 4-0 prolene suture in
a figure-of-eight fashion, and
avoid any significant length of
running suture, as any cinching
of the tissue may result in penile
curvature. In this figure, a
corporal injury is present with the
bullet visible (arrow)

Dorsal
neuro-
vascular
bundle

the knots buried to decrease the chance of the patient mentioned in the chapter section to follow. After you have
potentially feeling the suture under the thin penile skin reapproximated the skin, place a compressive dressing and
(Fig 51.2b). Avoid any significant length of running suture, remove it the evening of surgery or the following morning.
as any cinching of the tissue may result in penile curvature. Leave the catheter in place until the following morning
If there has been any rupture of the tunica albuginea close to unless a urethroplasty is performed. Administer antibiotics
1 cm or larger, perform an artificial erection after the repair. for 710 days following the repair to prevent penile abscess
This is necessary to determine if any curvature has resulted development.
from the repair. Do this by applying a tourniquet at the base Surgical exploration may be unnecessary if the penetrat-
of the penis and injecting one of the cavernosal bodies, via a ing penile injury fails to result in tunical violation. Relatively
butterfly needle, with normal saline until appropriate turgor small penile tears can be locally irrigated, debrided, and
is achieved. If there is any notable curvature, a plication of repaired with simple, interrupted closure and an absorbable
the tunica on the opposite side of the defect may be neces- 2-0 or 3-0 suture. With larger defects, initially perform local
sary. Repair any urethral injuries over a urethral catheter as irrigation and debridement. Evaluate the wounds later for
51 Lower Genitourinary Injuries 401

either primary closure with reapproximation or reconstruction owing to the shorter urethral length, greater urethral mobil-
with delayed grafting. These wounds are frequently contami- ity, and lesser pubourethral attachments in females.
nated, and all patients should be placed on a 10-day antibi- The diagnosis of urethral injury would ideally be elicited
otic course with an antibiotic that provides adequate coverage from a detailed history and physical examination. For obvi-
of typical skin flora, such as cephalexin. For penicillin- ous reasons, this is not always the case. Often, the urologic
allergic patients, you can use chloramphenicol. team becomes involved after prior failed attempts have
Penile amputation injuries can be accidental or self- already been made in the emergency department (ED) to
inflicted. The timing of the incident and the presence and place a urethral catheter. This often culminates in improper
handling of the severed penis are crucial to the initial man- catheter placement with possible conversion of a partial ure-
agement. The severed penis should be wrapped with saline- thral tear to a full and circumferential urethral tear. We try to
soaked gauze, placed into a sterile bag (if possible), and emphasize not attempting blind urethral catheterization if
immediately placed in ice water. The ice should never be in there is any suspicion of urethral injury. The mechanism of
direct contact with the penis to prevent necrosis. If possi- injury should prompt the initial suspicion for urethral injury.
ble, the amputated penis should be reimplanted within 24 h Failure to void since the incident or suprapubic fullness/dis-
of the injury. Transfer to a tertiary medical center is usually tention should be assumed to represent urethral injury until
required for the expertise of microvascular anastomoses proven otherwise. Gunshot wounds with either an entrance
that is often necessary. After appropriate medical and psy- or exit from the perineum or penis should alert any diagnosti-
chosocial issues have been addressed and other more life- cian to a possible urethral injury.
threatening injuries have been ruled out, the patient is taken The classical finding of a urethral injury on examination
to the operating room immediately for reimplantation. It is is the presence of blood at the meatus, though its presence is
extremely important to have an experienced team of urolo- not definitive evidence and its absence is not exclusionary.
gists, plastic surgeons, and OR staff in order to have a good Severe or expanding scrotal swelling, with or without ecchy-
result. Of primary importance is the cavernosal and spon- mosis, may also suggest urinary extravasation. Perineal
giosum/urethral reanastomoses. A urethral catheter is hematomas, which can take on the classic butterfly hema-
inserted prior to the urethral anastomosis. Microsurgical toma pattern, should also alert the clinician for further ure-
techniques can be used to reapproximate the dorsal arteries thral workup. Hematoma along the entire penile shaft
and nerve of the penis to improve the recovery of postop- (so-called sleeve hematoma) can be secondary to penile, ure-
erative perfusion and sensation, respectively. Next, the thral, or testicular injury.
tunica should be reconstructed. Finally, the debrided skin With any of the aforementioned history or physical
should be sewn together, much like any other superficial exam findings (suspected mechanism of injury, penetrating
anastomosis. It is not unusual to have delayed sloughing of injury, blood at the meatus, scrotal/perineal hematoma),
the penile skin. This does not necessarily imply that the one should proceed with a retrograde urethrogram (RUG)
reimplant as a whole has not survived. Delayed skin graft- or attempt gentle catheter placement. The RUG can be per-
ing may be all that is necessary. If the severed penis is not formed in several ways and can be done either in a formal
available, then overclosure of the corpus cavernosum with radiology suite with the combination of fluoroscopy, in the
advancement of the urethral stump can be performed to ED, operating room, or at the bedside. A 1214 Fr catheter
allow voiding while standing. An inadequate distal urethral can be inserted just into the fossa navicularis, with only
remnant may obviate the need for perineal urethrostomy 12 cm3 instilled into the balloon to tamponade the urethra
with delayed genital reconstruction pending complete psy- and prevent the antegrade leakage of contrast. Next, inject
chosocial evaluation. about 1520 cm3 of contrast, with the radiograph being per-
formed at the end of the injection to ensure adequate ure-
thral distention. Alternatively, the aforementioned
51.3 Urethral Injury procedure can be performed with a 60 cm3 catheter tip
syringe (filled with contrast) inserted very gently into the
As with other traumatic genitourinary injuries, the mecha- urethra until a snug fit is obtained. At our institution, the
nism of urethral injury can be divided into blunt versus pen- RUG is performed by placing the patient in a slightly lat-
etrating. Urethral injuries can be further subdivided into eral (about 3045) decubitus position. The penis is appro-
posterior (prostatic/membranous urethra) and anterior (bul- priately sterilized with a Betadine preparation and sterile
bar/pendulous urethra) in location. These subdivisions not draping placed underneath the penis. Next, about 20 cm of
only classify the location of the injury but also dictate further a small Kerlix roll is cut, soaked with water/saline, and then
management. Penetrating anterior and posterior urethral tied to the subcoronal position of the penis with a simple
injuries are usually secondary to gunshot and stab wounds. tie. This maneuver will allow penile traction during con-
These injuries are much more prevalent in males than females trast instillation to help delineate the entire urethra, as well
402 D. Hannoun and C.D. Best

as appropriately shield the examiners hands/body from the Therefore, the overall clinical status of the patient as well
radiation field. A separate catheter tip is then lubricated and as concomitant injuries should be taken into account
placed on a 60 cm3 Luer-Lok syringe prefilled with con- before final management decisions are made. These same
trast, and the injection is performed. The radiograph is complications do not apply to penetrating injuries, with
taken after 20 cm3 of contrast has been instilled. Urethral the exception of stricture rates. The high impotence and
injuries on an RUG will appear as a disruption of the nor- incontinence rates are more specific to the nature of the
mally concentric urethra from the meatus to the bladder pelvic fracture injury. Penetrating injuries are more com-
neck. A partial disruption represents extravasation along mon in the anterior urethra, with less disruption of the
the course of the urethra with some contrast instillation into surrounding neurovascular bundles.
the bladder, whereas a complete disruption will fail to fill Immediate surgical repair of posterior urethral injuries
the bladder at all, with contrast accumulating in a periure- is indicated in the presence of a concurrent bladder neck or
thral or perivesical location. rectal injury to prevent subsequent urinary incontinence,
The management of urethral injuries can be divided fistula formation, or persistent leak. Urinary continence is
simply into immediate open surgical repair versus tempo- a function of both the internal and external sphincter
rary urinary diversion with suprapubic or urethral catheter mechanisms. Posterior urethral injuries are usually associ-
placement. With temporary urinary diversion, delayed ated with damage to the external sphincter mechanism for
repair and/or reconstruction would be performed, if nec- urinary continence. This would leave the internal sphinc-
essary, 612 weeks following the injury. In any situation, ter, located at the bladder neck, as the only remaining
the initial management of urethral injury should proceed source of urinary continence. For this reason, any bladder
first and foremost with prompt bladder decompression neck injuries should be explored and repaired immedi-
and broad-spectrum antibiotics. The controversial aspect ately; without proper repair and reapproximation of the
of managing penetrating urethral injury, however, is sphincter, eventual urinary incontinence is almost guaran-
whether immediate open repair versus diversion with teed. In the absence of a bladder neck or rectal injury, pos-
delayed repair and reconstruction should be performed. In terior urethral injuries should be managed with temporary
a recent study and review of posterior urethral injuries urinary diversion via suprapubic or urethral catheter place-
with pelvic fractures, immediate open repair was associ- ment. The placement of a urethral catheter in the presence
ated with a 49 % stricture rate, 21 % incontinence rate, of a urethral injury is called immediate endoscopic (or pri-
and 56 % impotence rate. When primary realignment was mary) realignment (IER). Regardless of mechanism, pos-
performed, the stricture rate remained at 53 %, but the terior urethral injuries are initially managed with an
incontinence and impotence rate dropped to 5 % and 36 %, attempt at immediate endoscopic realignment. Traverse
respectively. When suprapubic urinary diversion was the the normal urethral mucosa by using flexible cystoscopy
initial management option, the urethral stricture rate rose with low-flow irrigation. Once you reach the site of injury,
to 97 %, with a 4 % incontinence and 19 % impotence rate. the cystoscope is often successful in identifying some nor-
In a recent retrospective series by Hadjizacharia et al., 14 mal mucosa or the other side of the defect (Fig. 51.3).
patients presenting with an acute urethral injury were Once across the defect and into the bladder with the cysto-
managed with immediate endoscopic realignment (IER), scope, advance a guide wire into the bladder. Then remove
compared to seven patients treated with delayed (open) the cystoscope and place a Council tip Foley catheter over
therapy. The outcomes of the study showed the immediate the wire and into the bladder. This allows urethral drainage
realignment group to have a lower rate of stricture forma- without necessitating surgery. The majority will heal with-
tion (14 %) compared to the delayed therapy group out significant stricture. If attempts at IER are unsuccess-
(100 %). In addition, the authors found a shorter time to ful, a suprapubic tube can be placed, followed by delayed
spontaneous voiding in the immediate realignment group definitive repair.
(35 23 days) compared to the delayed therapy group Anterior urethral injuries can also be repaired early on
(229 79 days). A long-term review at the same institu- with open surgery, especially in the setting of low-velocity
tion had similar results. Thirty-five patients with poste- penetrating injuries where major tissue destruction has not
rior, acute urethral injury underwent immediate occurred. In the presence of major tissue destruction,
endoscopic realignment. Five of these patients had pene- excessive and often inadvertent tissue debridement may
trating injury as the mechanism. After 18 months, the rate take place, which can further the risk of ischemic stricture
of stricture formation was stable at 17 %. Only three of the development. In cases of anterior urethral repair for pen-
six patients who developed stricture required urethro- dulous urethral injuries, approach with a circumcision/
plasty, and none of the patients with penetrating mecha- degloving penile incision and proceed to local debride-
nism went on to develop stricture. In general, no single ment of nonviable tissue, spatulation of the two urethral
treatment protocol will fit each patient perfectly. ends, and a tension-free anastomosis of the lacerated
51 Lower Genitourinary Injuries 403

Fig. 51.3 Once you reach the


site of urethral injury, the
cystoscope is often successful in
identifying some normal mucosa
or the other side of the defect Cystoscope

Injury

corpus spongiosum and urethra with interrupted absorb- placement over a wire. As an alternative, antegrade
able sutures over a 1416 Fr urethral catheter. For bulbar urethroscopy can be performed at the time of open pelvic
urethral injuries, place the patient in the dorsal lithotomy surgery or during repair of a concomitant bladder rupture
position, and make a vertical perineal incision to gain with passage of the scope down the urethra and out of the
access to the bulbar urethra. Carry a tension-free urethral meatus. This will allow tying of a catheter to the cysto-
anastomosis; perform it over a 1618 Fr catheter in this scope with a silk suture or over a wire and retrograde pas-
relatively dilated portion of the urethra. Keep the catheter sage of the catheter into the bladder as the cystoscope is
in place for a minimum of 1014 days, and perform a peri- withdrawn.
catheter RUG prior to removal to ensure no further extrav- In summary, penetrating injuries to the urethra, testi-
asation. The presence of extravasation warrants continued cles, and external genitalia usually take the form of gun-
catheter drainage. shot and stab wounds. The importance of the mechanism
Urinary diversion with delayed repair is another man- of injury cannot be overemphasized, and combined with a
agement option, especially when the patient is too unsta- very thorough and detailed physical examination, it will
ble for surgery or if the injury is very posterior. If IER lead the diagnostician to the correct diagnosis. If ever in
fails, urinary diversion can be performed with suprapubic doubt, or the mechanism does not seem correct, perform
cystostomy tube placement (percutaneous versus open). radiological studies to further delineate any underlying
Open suprapubic cystostomy placement will guarantee injuries, which may of course change the course of man-
placement into the bladder, allow concomitant bladder agement. Other life-threatening injuries should always
repair if present, and allow bladder neck reconstruction if maintain a higher priority, but it is the responsibility of the
an injury is found. Open tube placement will also allow trauma and urology team to work together and maintain
antegrade urethral endoscopy and urethral catheter place- effective communication to deliver the best possible care.
ment if initial catheter placement or retrograde urethros-
copy failed to reach the bladder. The other option for
suprapubic cystostomy tube placement is a percutaneous
kit, which is less invasive than the open suprapubic tube Important Points
placement and can be performed under mild sedation.
Blind urethral catheter placement, on the other hand, can An Inferior Vena Cava (IVP) or CAT Scan (CT)
be attempted in the setting of small, partial lacerations alone is not always reliable to demonstrate bladder
and in general should be avoided because of the risk of rupture. This requires a high-pressure cystogram.
transforming a partial laceration to a full circumferential Undiagnosed bladder rupture in the presence of pel-
transection. Again, we emphasize obtaining an RUG if vic fracture can lead to serious complications.
any index of suspicion for urethral injury is present. Urethral injury can be associated with rupture of the
However, the catheter can be safely placed under direct bladder.
visualization with retrograde urethroscopy and catheter
404 D. Hannoun and C.D. Best

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18. Pliskow RJ et al (1979) Corpus cavernosography in active fracture
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of the penis. Am J Roentgenol 133:331332
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