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1. OILAHUASCA

2.

3. Oilahuasca is a mix of psychedelic allylbenzene oils and enzyme inhibitors used to create a psychedelic experience. The

allylbenzene oils themselves are often inactive, but when mixed with the proper enzyme inhibitors a psychedelic experience is

possible. The word oilahuasca draws from the word ayahuasca which defines a mix of herbs in which DMT is made orally psychedelic

by using enzyme inhibitors in much the same way as oilahuasca. The word oilahuasca was originally coined by 69Ron.

4.

5. THE PSYCHEDELIC ALLYLBENZENES

6.

7. The main key ingredients in oilahuasca are the psychedelic allylbenzenes myristicin, elemicin, safrole, and methyl chavicol.

Others are possibly active but have not been tested. The corresponding propenylbenzenes like anethole, isoelemicin, etc., are

probably not active, or very weak. Tests done using anethole did not find it active at doses which are active for methyl

chavicol, its allylbenzene form.

8.

9. Myristicin is mostly known as the main active in nutmeg oil, however it occurs in much greater quantities in Hungarian parsley

seed oil. Myristicin produces a psychedelic effect thats like a mix of MDMA and mescaline when properly activated. Its quite

speedy however. Myisticin is primarily inactivated by P450 enzymes CYP1A2 and CYP3A4. The P450 enzyme CYP2D6 might be critical to

getting good effects from myristicin.

10.

11. Elemicin is found in elemi oil, and nutmeg. This is more difficult to get working than myristicin. When activated properly, it

produces effects like those of mescaline. When not activated properly it produces mild sedative effects like those of melatonin,

which is not at all psychedelic. Elemicin is mostly inactivated by conversion to 1-hydroxy-elemicin. Its unknown exactly which

P450 enzymes do this, but its highly likely that CYP1A1, CYP1B1, CYP1A2, CYP2A6, CYP2C9, and CYP2E1 can all cause 1-hydroxy-

elemicin to form. CYP2D6 might be needed for psychedelic activity.

12.

13. Safrole is found mainly in sassafras oil but is also found in nutmeg in much smaller amounts, but enough to affect the nutmeg

trip. When activated, this produces effects similar to MDMA. Its not very visual; its more of an empathogen than a psychedelic.

When not properly activated it produces a mild sedative effect thats not psychedelic. The P450 enzymes CYP2A6, CYP2C9, and

CYP2E1 primarily inactivate safrole by conversion to 1-hydroxy-safrole. CYP2D6 might be needed for psychedelic/empathogenic

activity.

14.

15. Methyl chavicol is found in sweet basil oil. When properly activated this produces an electric LSD-like psychedelic effect. Its

a great mood enhancer, aphrodisiac, and also produces some visual effects. When not properly activated this produces a sedative

effect thats almost like marijuana, but not at all psychedelic. The P450 enzymes CYP1A2 and CYP2A6 cause the inactive 1-hydroxy-

methyl chavicol to form. Its possible that CYP2D6 is needed for psychedelic activity.

16.

17. While some of the oils are known to be inactivated by certain P450 enzymes, primarily by 1-hydroxylation, in many cases if the

primarily P450 enzymes are inhibited, other P450 enzymes will take their place. This means that more than just the primary P450
 enzymes should be inhibited.

18.

19. Methyl chavicol and myristicin seem to be much easier to activate than elemicin or safrole. Often myristicin is active on its

own.

20.

21. Of the main oils, nutmeg oil is usually the most active on its own without taking other oilahuasca enzyme inhibitors. The reason

for this is not entirely known however nutmeg oil does sometimes contain substantial amounts of its own P450 inhibitors. Also

myristicin itself is often active without inhibitors.

22.

23. Basil oil is the least active on its own, often producing no psychedelic effects at all, but is also the easiest to activate.

24.

25. Sassafras oil sometimes works on its own in some people, but this is rare.

26.

27. Elemi oil sometimes works on its own.

28.

29. OILAHUASCA P450 ENZYME INHIBITORS

30.

31. The psychedelic allylbenzene essential oils safrole, elemicin, methyl chavicol, and myristicin are all attacked by P450 enzymes,

in many cases this renders these oils completely inactive. This is why some people cannot trip from nutmeg oil, elemi oil, basil

oil, or sassafras oil. Of these three the most active taken on its own is usually nutmeg oil because it contains its own

oilahuasca inhibitors in substantial amounts, while elemi oil, basil oil, and sassafras oil do not.

32.

33. After extensive testing by AFOAF, hes come up with an oil mix that does a great job as an oilahuasca pre-dose inhibitor for

safrole, elemicin, methyl chavicol, and myristicin, which will also probably work for the majority of the other potentially

psychedelic allybenzene oils.

34.

35. He uses 1-3 drops of clove leaf essential oil, 3-6 drops of German chamomile essential oil, and 5-10 drops of cinnamon bark

essential oil. This is taken 30-60 minutes before taking the psychedelic oils, and for good measure once again along with the

psychedelic oils. Its best to take these pre-dose oilahuasca inhibitors in a capsule. In some sensitive individuals cinnamon can

irritate the mouth. For AFOAF, cinnamon doesnt irritate his mouth, but even so, he takes these inhibitors in a capsule on an

empty stomach, followed directly by a little food to help digest them.

36.

37. Cinnamon bark oil takes care of CYP2A6 and CYP2E1 nicely, I dont know if it can knock out CYP2C9. Thats where clove leaf comes

in because it knocks out CYP2C9 very well along with CYP3A4, CYP1A1, and CYP1B1. Also German chamomile oil knocks out CYP1A2. By

having CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, CYP2E1, and CYP3A4 inhibited while leaving CYP2D6 alone, you help ensure that

these psychedelic oils are not inactivated orally.

38.

39. The dosage needed for these inhibitors for each person is going to vary. Some people might need 2-3 times as much. Its best to

start on the low dosage end for these inhibitors and then up the dose a few drops at a time for each test until one finds their

own specific dosage that works.

40.

41. Failure to take enough inhibitors may cause the psychedelic oils to fail to elicit psychedelic effects.

42.

43. OILAHUASCA ACTIVATION

44.

45. Once the proper P450 ezymes are inhibited, it is still possible that the psychedelic oils will not work in some people.

46.

47. There are at least two steps to the oilahuasca process. The first step is inhibiting the P450 enzymes that inactivate these oils.

Getting these oils past the P450 enzymes is just half the problem. The next step is activation of these psychedelic oils by a

currently unknown process within the human body. For some reason allylbenzenes can be activated, while propenylbenzenes do not

seem to get activated, or require huge doses to become active. Why allylbenzenes work and propenylbenzenes dot not seem to work

is a mystery. Its been theorized that the allybenzenes can form amphetamines within the human body if they pass through the P450

enzymes unaltered. This has been found to occur in a few animal tests, but has been found not to occur in most animal tests. The

other theory is that phenethylamines form. To this day however its unknown what activates these oils in humans. Fortunately it

is fairly well known what makes them inactive however, and thats certain P450 enzymes.

48.

49. To help activate these oils once they get past the P450 enzymes, a few tricks have been posted on various forums. One method some

use is excessive exercise. Another rarely reported method is to take these oils with amphetamine. Yet another reported method is

to take the oils with phenethylamine. Another is to take them with phenylalanine. These are not well tested and may not work for

all people. How they work is not known. For AFOAF, these are not required. His body is able to activate these oils 100% of the

time just as long as the proper oilahuasca P450 enzyme inhibitors are used prior to taking the psychedelic oils.
 50.

51. Its possible that phenethylamine and phenylalanine taken orally with the oils are broken down and metabolites of these are used

by the body to synthesize phenethylamines from these psychedelic oils once they get past the P450 enzymes. This is debated

however.

52.

53. Another possibility is that these tricks serve to increase metabolism, which in turn increases oxygen levels, and this might play

a role in their activation. Again, this is unknown.

54.

55. If the second piece of this puzzle can be solved, it may be possible for these oils to work in all people. They currently do not

work in all people, even with the proper P450 enzymes inhibited.

56.

57. ENHANCERS

58.

59. Coffee seems to always enhance and help activate these oils if taken 30-60 beforehand. How this works is unknown. Any coffee

works. You don't need much, say 1 or 2 cups. The boost is not that much as you'd get from the inhibitor oils mentioned, but it

makes a noticeable difference when used with them. If one is a coffee drinker, definitely use coffee to drink down the inhibitor

oils in a capsule before taking the psychedelic oils. Follow that quickly with a piece of bread or something similar to stimulate

digestion.

60.

61. There's some controversy about whether or not coffee inhibits CYP1A2 or induces it. I can't seem to get clear cut facts on that.

I've seen countless studies that say one or the other with solid tests to back up their findings.

62.

63. I think the coffee boost is not CYP1A2 related. Even when taking 10 drops of German chamomile oil, which is way more than one

would normally use to inhibit CYP1A2, the coffee still acts as a booster. I think it's another action the coffee is causing which

is separate from it's action on CYP1A2 that's boosting the effects of these psychedelic oils.

64.

65. Coffee is also known to boost the effects of mescaline. Mescaline is supposedly not affected by CYP1A2 like its close psychedelic

oil relatives are, so coffee's ability to boost mescaline's effect should not be related to CYP1A2. It would be nice to know just

how exactly coffee works to boost the effects of these oils, I'll bet it's something similar to how it works to boost the effects

of mescaline.

66.

67. If anyone knows how exactly coffee boosts the effects of mescaline I would love to hear the reason for it. Maybe it will help

shed some light on how these psychedelic oils work. Maybe there's another herb that can do this better than coffee can.

68.

69. Cayenne pepper, at 800 mg in a capsule, boosts the effects of these oils if taken AFTER the oils are taken. How this works is

unknown.

RAW Paste Data

OILAHUASCA

Oilahuasca is a mix of psychedelic allylbenzene oils and enzyme inhibitors used to create a psychedelic experience. The
allylbenzene oils themselves are often inactive, but when mixed with the proper enzyme inhibitors a psychedelic experience
is possible. The word oilahuasca draws from the word ayahuasca which defines a mix of herbs in which DMT is made orally
psychedelic by using enzyme inhibitors in much the same way as oilahuasca. The word oilahuasca was originally coined by
69Ron.

THE PSYCHEDELIC ALLYLBENZENES

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