isynth catimpreg

Heterogeneous Catalyst Preparation by Automated Versatile

Impregnation

Customer testimonials
Fast catalyst optimization (selectivity and conversion) as a result of automated synthesis and screening of 2
generations of catalysts. Development time decreased by 50%!
We used to take 3 to 5 years to transfer a new catalyst to business, now the company does so in one year!
So basically every year one new catalyst.
... More than 20 different impregnation methods have been successfully implemented on these platforms...
Robustness and Ease-of-Use by Design
The leading technology in overhead gravimetric dispensing / dosing (patented)
combined with our disposable or reusable reactors, and our user-friendly
software, allow you to standardize and accelerate your
parallel impregnation workflows.

Precision Speed Accuracy

Performance Versatility
R&D Cost Savings High-Throughput

Key Advantages:
Decrease in cost per experiment up to 90+ %.
Increase in productivity by a factor of 10+.
Easy-to-use disposable glass reactors / vials and / or reusable double-jacket reactors.
High-throughput catalyst preparation by e.g. incipient wetness
and excessive liquid impregnation.
4-Needle Head for volumetric liquid handling and sampling.
Gravimetric solid dispensing into an unlimited choice of vial / plate /
reactor formats.
The balance moves to the destination, increasing speed and efficiency.
Balance resolution of 0.1 mg, or 0.01 mg.
A large dispensing range, from a few mg up to several grams.
Configuration for impregnation can be combined with other tools to
accommodate multiple workflows.
Dispensed amount, mixing speed, temperature, time..., and other data
are stored in a read only log file.
Easy access to data with a convenient interface to pull results into Excel or
virtually any other software.
Interface to DOE.

isynth reactor blocks with disposable glass vials and /

or reusable quartz vials

isynth catimpreg workstation

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Enhance your Efficiency and Productivity with our Workflow Solutions!

Dispensing Dispensing
Dispensing Adding Heating and
Precursor Precursor
Water Acid / Base Mixing
Metal I Metal II

Dispensing
Extrudate

Measuring and Measuring Drying

Impregnation Aging Drying
Adjusting pH Density Dispensing
Crushed
Extrudate

Excellent homogeneity

Overhead gravimetric Overhead gravimetric Overhead volumetric and gravi- Impregnations: incipient wetness,
dispensing of solids into dispensing of liquids into metric aspirating and excessive liquid, vacuum,
synthesis reactor arrays synthesis reactor arrays dispensing of viscous liquids, precipitation
density measurement on-the-fly

Chemspeeds Unique, Proprietary Array Synthesis Reactor Technology with Disposable Vials

Overhead gravimetric dispensing for

powders & extrudates (dispensing range
up to 100 g, readability down to 0.1 mg)

Volumetric dispensing of liquids

(syringe volumes: 1, 10, or 25 mL) for
viscosities from 1 mPa.s to 200 mPa.s

Overhead gravimetric dispensing for

highly viscous liquids for viscosities from 1
mPa.s to 500+ Pa.s (dispensing range up
to 100 g, readability down to 0.1 mg)

Overhead gravimetric dispensing for

solids (dispensing range up to 20 g, reada-
bility down to 0.1 mg)

Reflux, filtration, evaporation plate

Shaking frame with heating/ cooling

Orbital shaking
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Technical Details
isynth dimensions:
Chemspeeds isynth catimpreg deck modularity allows the user to execute 1480 x 910 x 1860 mm
and perform a variety of catalyst impregnation workflows in a fully automated fashion. (4 4 3/8 x 3 x 6 1 1/4)
isynth xl dimensions:
2350 x 950 x 1920 mm
isynth Components (7 70 x 3 2 x 6 4)

Shaker / Stirrer Inserts & Vials Heating / Cooling Reaction processing & isynth Reactor
Work-up Block

48 X 8mL screw cap vials
or
+ +
HTF-oil heating/cooling plate Individual ceramic plates with
(requires cryostat) automatic opening & closing of
or reactors enabling inertisation, re-
flux and evaporation of reaction
solution
Option: additional plate for
+ =
filtration or filtration to waste

Shaker 2.25mm radius 24 X 20mL screw cap vials Electrical heating plate
or or or

100mL screw cap vials
on request
Combined electrical heating
and HTF-oil based
cooling (requires cryostat)
Coated metal plate with septa
closing of reactors enabling
inertisation and evaporation of
reaction solution
Option: filtration to waste

Preparation of impregnation solution with heating under reflux, pH measurement and adjustment as well
as density measurement and adjustment.
Incipient wetness and excessive liquid impregnation while shaking and heating in high quality (disposable)
vials / reactors.
High-quality quartz reactors for direct use in calcination.
Integrated washing, filtration and drying.
Disposable glass
vial / reactor
Integrated pH and density measurement / adjustment.
Variety of reactors with heating, reflux, vacuum, filtration.
Efficient mixing by shaking while preserving the extrudates.

Volumetric dispensing and aspiration of liquids is done with a Multi-Channel Liquid Handling Tool (4-Nee-
dle Head), with four independent needles. The four needles can be operated simultaneously or individually.
If required the tool can be equipped with needles of different inner diameters. Larger diameter needles for
the handling of suspensions or liquids with higher viscosities, smaller diameter needles for handling of small
volumes.
4-Needle Head

The Gravimetric Dispensing Units
for solids and powders
(SDU, GDU-P)
The Gravimetric Dispensing Units (SDU and GDU-P models) are used to perform automated, gravimetrical-
ly controlled dispenses of a wide range of solids and powders in the milligram to multigram scale. The mod-
ules pick the appropriate chosen container, dispense the solids and powders, and then place the container
back to its station before picking the next one. Both dispensing units include an overhead balance, and allow
dispensing and simultaneous weighing of solids and powders into various vials, reactors, well-plates.

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4 Dimensions of Modularity and Flexibility
Complete intuitive, flexible,
software solution: design,
execute, analyze, report
(variety of 3rd party Off-the-Shelf-Design
softwares, e.g.:
JMP, Spotfire)
Individual platform configuration
Variety of 3rd tailored to your workflow with market-
party instruments
More than 50 robotic proven off-the-shelf components.
e.g.: rheometer,
centrifuge, microwave, tool-features available
GC, HPLC, GPC, NIR, (patented) Robotic platforms which can easily be
PSD, cryostats, integrated with one another to enable
vacuum multi-workflow processes (e.g. Formulation,
pumps, Application and Testing procedures all
integrated in a single platform).
Broad selection of
racks, vials, plates,
precision reactors and
formulation vessels / blenders

Complete Software Solution: Design, Execute, Analyze, Report

Chemspeeds AutoSuite User Interface & Executor software packages execute and control all modules of the entire product development cycle.
They control all Chemspeed robotic platforms and any other integrated 3rd party software and hardware.

AutoSuite isynth is a software with a user friendly interface which

allows easy workflow orienteted programming. Many features such as
gravimetric dispensing are automatically calibrated, eliminating tedi-
ous optimization steps.

The AutoTeaching tool simplifies dispensing applications without

Dro nd

manual trials and is applicable to e.g. solids eliminating the need

ga
p
Dra

for manual optimization before the dispenses are done.

Easy programming: drag-and-drop workflow steps or just
execute standard workflow protocols.
Barcode tracking.
Easy integration with virtually any LIMS or ELN software.
AutoSuite Application Programming Interface (API) for 3rd party
software and hardware integration.

Optional, Chemspeed VLab for DoE and Data Analysis / Reporting.

It includes a full document management system (electronic lab-
journal) and is 21 CFR Part 11 compliant. The software scales from
a single PC to large network installations with multiple
hardware and clients.

Easy Programming - Intuitive interface

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 Platform Configuration Example

Exemplary isynth catimpreg deck with liquid storage racks, syringe

pumps, containers, holders and the following tools: a 4-Needle Head
for liquid dispensing, a Solid Dispensing Unit (GDU-P) for
solid dispensing, a Viscous Liquid Dispensing
Unit (GDU-V) for liquid aspirating and
a Multigripper for vial transfer.

4-Needle Head liquid transfer Overhead gravimetric (viscous)

tool with coated needles for e.g. liquid aspirating / dispensing tool Rack for 30x60 mL Syringe pumps for
water, acids, bases with pH double (GDU-V) or on-deck balance for vials for liquid storage 4-Needle liquid
needle and filtration extension e.g. density measurements (other sizes available) transfer tool

Multigripper for
ISYNTH blocks

Holders for e.g.

2x250 mL bottles
for e.g. H3PO4,
aq. NH3
(additional racks
available)

Containers for storage of metal
salts and extrudate supports
(additional containers available)
ISYNTH reactor block with 12x100 mL or
24x20 mL disposable or reusable reactors for
(metal) salt solution preparation, incl. inertisation,
evaporation, refluxing, filtration of reaction
solution (other sizes available)
ISYNTH reactor block with 24x20 mL Overhead gravimetric
disposable or reusable reactors for cat- dispensing tool for powders,
alyst impregnation, incl. inertisation, solids and extrudates
evaporation, refluxing, filtration of (GDU-P)
reaction solution (other sizes available)

All tools and accessories from Chemspeeds Swing, autoplant, Formax, Applicator and Investigator platforms
are fully compatible with the isynth catimpreg platforms and vice versa.

Available upgrade options:

Large choice of sample, reagent and customized racks.
...

Variety of Plug-in (3rd Party) Solutions

Chemspeed integrates a large number of 3rd party components either on and / or off the deck.

Available upgrade options:

Drying / desiccation, calcination, compaction, crushing, sieving module.
Analysis module (BET, pore size distribution, Raman, ...).
...
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 Robotic Tool-Features

More than 50 robotic tool-features can be integrated including unrivaled overhead gravimetric dispensing, which can oper-
ate while mixing, heating and cooling. Virtually any combination of these robotic tools is possible.

Highlighted are the most common and recommended robotic

tool-features for the isynth catimpreg robotic platform.
Robotic tool
exchange interface
(proprietary)

Precision balance
Volumetric dispensing Action Analytic
Overhead gravimetric dispensing
robotic tools robotic tools robotic tools
robotic tools
(proprietary)

Overhead gravimetric 1:1 pick & Liquid handling powered by 4 Multigripper for vial and Online density measurement
place / dispense of solids & powders syringe pumps (syringe volumes: MTP transport and much (aspiration technology), on the fly
DIRECTLY from virtually any source 1, 10, or 25 mL) for viscosities more resolution: 1 mg
to any destination (<0.1 mg to from 1mPa.s to 100 mPa.s Automated barcode (or 0.01 mg with
about 30 mg) Special options: scanner second balance)
Disposable pick & Disposable tips
Screw capper
dispense tips (1200 L)
Vial diameter range: Brookfield Viscosimeter
(no dead volume) Disposable syringes
from 10 mm to 50 mm (RVDV-II+ Pro BK)
resolution: 0.1 mg Heated needles
Larger ranges available
(or 0.01 mg with a second balance) (up to 100C)
Torque range: from 0.1 Nm to 1 Nm
Spray needles
Overhead gravimetric pH and temperature measurement Capping, crimping
fine dispensing of and control (N8 / N11 / N13 / N20)
solids & powders Coated needles, PEEK needles... Decapping (N8 / N11/
(0.1 mg to 10 g) N13 / N20)
Dispensing container Liquid gas dispensing with
volume: 30 mL gravimetric control High shear Tri gloss measurement
resolution: 0.1 mg resolution: down to 0.1 mg homogenization Thickness measurement
(or 0.01 mg with a second balance) (11000 to 30000 rpm) Color measurement
Overhead gravimetric dispensing Precision tack-cure
of solids & powders (1 mg to
100 g, larger volumes
are available) Overhead stirrer Camera
Dispensing container (20 to 200 rpm) Observation of dissolution
volume: 200 mL Different stirrer types available Particle size distribution and
resolution: 1 mg (or 0.01 mg with dynamic light scattering
a second balance) Ultrasonic dispersion
(100 W)
Overhead gravimetric dispensing
of highly viscous liquids,
pastes and creams
(1 mg to 100 g) with
viscosities from Vacuum / Degassing
1 mPa.s to 500000 mPa.s Reflux condenser
(based on Newtonian substances) Evaporation
resolution 1 mg Filtration
(or 0.01 mg with a second balance)
Optional aspiration feature High speed injection molding
Optional transfer of hot (up to Foam formation
90 C) substrates via heatable
Draw-down with disposable or
cartridges (e.g. for waxes)
reusable precision spiral and / or
Overhead gravimetric aspiration gap bars
Overhead gravimetric / volumetric Free film generation
and dispensing of viscous liquids
aspiration and dispensing of viscous Dip coating
(1 mg to 100 g) with
liquids (0.1 L to Spray coating
viscosities from 1 mPa.s
12.5 mL) with Wet-on-wet coating
to 15000 mPa.s via
viscosities from 1 mPa.s
disposable positive
to 15000 mPa.s Robotic transfer
displacement syringes,
via disposable positive displacement arm to serve 3rd
resolution: 1 mg
syringes, resolution: down to 1 L party instruments
(or 0.01 mg with a second balance)
e.g. centrifuge
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 15+ Years of Experience in Automated Experimentation.
Customized Workflow Solutions.
Swiss Quality Products.
An International Team of Highly Experienced Chemists.

Chemspeed Technologies AG is the leading provider of high-throughput and

high-output research & development workflow-solutions from single bench-top /
standalone automated workstations (powder dispensing - sample preparation- syn- Headquarters
thesis - process development - formulation - application - testing) up to complete Chemspeed Technologies AG
and integrated product development workflows for the entire product development Wlferstrasse 8
processes in the chemical, material science, renewables & energy, pharmaceutical, 4414 Fllinsdorf
Switzerland
agrochemical, specialty chemical, home care, cosmetics and nutrition industries, as
Tel: +41 (61) 816 9500
well as academia.
Fax: +41 (61) 816 9509
chemspeed@chemspeed.com
www.chemspeed.com

US Office
Chemspeed Technologies Inc.
113 North Center Drive
North Brunswick, NJ 08902
United States
Tel: +1 (732) 329 1225
Fax: +1 (732) 329 1226
us@chemspeed.com
www.chemspeed.com

UK Office
Chemspeed Technologies Ltd. Department
of Chemistry, University of York Heslington,
York, YO10 5DD
United Kingdom
Tel: +44 (0) 1904 409579
uk@chemspeed.com
www.chemspeed.com

Discover our enabling portfolio for the entire product development cycle!
030.1024.B - 09/2014

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