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Significant outcomes
Yoga as an add-on therapy improved psychopathology, emotion recognition decits, and socio-
occupational functioning in antipsychotic-stabilized patients with schizophrenia in comparison with
Physical Exercise and Waitlist groups.
The maximum change in variables occurred at the end of 2nd month of follow-up in the Yoga group
and the benets obtained persisted at the end of 4th month of follow-up.
Facial emotion recognition decits were associated with poorer socio-occupational functioning at
baseline.
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Behere et al.
Limitations
Baseline matching of Waitlist and Yoga groups on parameters such as negative symptoms and Tool
for Recognition of Emotions in Neuropsychiatric DisorderS Accuracy Score may have improved the
methodology of the study.
A longer duration of supervised yoga therapy by the trained yoga therapist may have produced more
robust results.
The ndings need to be replicated in a larger sample of patients.
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Eect of yoga therapy on patients with schizophrenia
patients who completed all assessments at the end sad, fear, anger, surprise, disgust, and a neutral
of the study duration were included in the nal expression emoted by four experienced actors (one
data analysis. Those patients who dropped out or young man, one young woman, one older man,
those who required a change in dosage of antipsy- and one older woman). The performance on
chotics during the study duration were not TRENDS was assessed by calculating the total
included. During follow-up assessments, number number of images that were correctly indentied
of drop-outs was 7 in Yoga group, 14 in Exercise out of a maximum of 80 and termed the TRENDS
group, and 4 in Waitlist group. Hence, the number Accuracy Score (TRACS). Patients were assessed
of patients who completed the study and included at the baseline, 2nd and 4th month of follow-up.
in the nal analysis was 27 in Yoga group, 17 in All assessments were made by raters who were
Exercise group, and 22 in Waitlist group. The blind to the group status.
drop-outs were not signicantly dierent from the
nal study sample in their baseline clinical and
Statistical analysis
demographic characteristics. The patients who
dropped out either had not practiced yoga at One-way anova was used to assess dierences in
home or did not come for follow-up assessments baseline clinical and demographic variables among
because of logistical reasons. It is interesting to the three groups. The paired-samples t test was
note that none of the patients were excluded from used to assess the change in variables after the
the initial sample for reason of change in dosage of study period in the individual groups. Pearsons
antipsychotic medication. correlation analysis was performed to look at the
The yoga module developed by Swami Viveka- association between the clinical variables.
nanda Yoga Anusandhana Samsthana (SVYASA)
was used. The techniques have been reported in an
Results
earlier study (12); briey, it consisted of loosening
exercises, breathing practices, suryanamaskara, On one-way anova, the subjects in all three groups
sitting, supine, and prone posture asanas along were comparable on age, sex, and duration of
with pranayama and relaxation techniques. Med- illness. The three groups diered signicantly on
itation was not included in the module. The baseline negative symptoms (F = 4.8, P = 0.01)
exercises were adapted from the National Fitness and baseline TRACS (F = 3.2, P = 0.05) with the
Corps Handbook for Middle High and Higher Yoga group having greater negative symptom
Secondary Schools. It consisted of brisk walking, score and lower TRACS (Table 1).
jogging, and exercises in standing and sitting Change in variables between baseline and 2nd
postures and relaxation. For further details regard- month follow-up and baseline and 4th month
ing the yoga and exercise techniques, please see follow-up in the individual groups was examined
Appendix 1. using paired-samples t test (Table 2). In the Yoga
Patients socio-demographic data were collected group, there was signicant change in positive and
using semistructured data sheet. Their psychopa- negative symptoms and TRACS. The improvement
thology was assessed by Positive and Negative continued to remain signicant even after the 4th
Syndrome Scale (PANSS) (13). Socio-occupational month assessments. The improvement in positive
functioning was assessed by Socio-Occupational and negative symptoms and SOFS score remained
Functioning Scale (SOFS) (14). Their emotion signicant after applying Bonferroni correction for
recognition abilities were assessed using Tool for multiple comparisons. There were no signicant
Recognition of Emotions in Neuropsychiatric changes in variables in either the Exercise or the
DisorderS (TRENDS) (15). This is a culturally Waitlist groups. The maximum change in variables
sensitive, ecologically valid tool, consisting of 52 occurred at the 2nd month of follow-up. On
static (still) and 28 dynamic (video clip) images (i.e. correlation analysis, it was observed that lower
totally 80 images) of six basic emotions happy, baseline scores on TRACS correlated with poorer
Table 1. One-way anova chi-square analysis of baseline clinical and demographic variables in patient groups
Variable Yoga (Mean SD) Exercise (Mean SD) Waitlist (Mean SD) F (v2) P
Age (years) 31.3 9.3 30.2 8.0 33.6 9.9 0.74 0.5
Duration of illness (months) 126.2 101.6 86.6 93.1 121.6 108.6 0.82 0.4
Sex (M : F) 18 : 9 14 : 3 15 : 7 1.4 0.5
Mean dosage of antipsychotic and 335.0 205.3 [400] 297.9 150.9 [300] 340.0 172.4 [675] 0.21 0.8
[range] (CPZ equivalents in mg day)
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Behere et al.
Table 2. Pairedsamples t test comparing change in variables from baseline to 2nd month$ and 4th month# of follow-up in individual patient groups
Group Variables Baseline 2nd month 4th month t$ value P$ value t# value P# value
Yoga Positive symptoms 15.1 11.7 11.9 4.7 12.1 5.4 3.5 0.002* 2.8 0.008*
Negative symptoms 17.8 4.9 14.7 3.9 14.7 3.8 5.1 <0.001* 3.5 0.002*
TRACS 49.4 11.4 54.1 11.7 54.6 14.4 2.3 0.03* 1.8 0.09
SOFS score 30.8 7.4 25.1 6.4 25.7 7.9 4.4 <0.001* 0.38 0.7
Exercise group Positive symptoms 14.9 4.3 13.5 4.7 14.1 5.4 1.5 0.2 0.6 0.6
Negative symptoms 14.8 3.9 13.9 3.3 13.5 4.4 0.94 0.4 1.5 0.2
TRACS 51.3 10.7 51.2 10.7 52.8 10.4 0.03 0.9 0.65 0.5
SOFS score 26.2 5.1 23.9 4.7 22.0 6.8 1.9 0.07 1.3 0.2
Waitlist group Positive symptoms 14.7 6.3 12.9 5.2 11.8 5.6 1.7 0.1 2.02 0.06
Negative symptoms 14.3 3.7 13.7 3.7 13.7 3.6 0.61 0.6 0.65 0.52
TRACS 56.9 9.4 58.4 8.9 53.4 16.4 0.74 0.5 0.99 0.3
SOFS score 27.1 6.6 24.9 6.1 25.2 5.4 2.1 0.05* 0.27 0.8
SOFS, Socio-Occupational Functioning Scale; TRACS, TRENDS Accuracy Score; TRENDS, Tool for Recognition of Emotions in Neuropsychiatric Disorders.
*Significance at P < 0.05.
socio-occupational functioning as measured by social situations and hence can aect socio-
SOFS (r = 0.3, P = 0.01). There was no signi- occupational functioning (16). However, interven-
cant correlation between TRACS and positive or tions to improve these decits are limited. We
negative symptoms. There was no signicant cor- recently reported risperidone to improve FERD in
relation between change in negative symptoms and antipsychotic-nave schizophrenia (10). Structured
change in TRACS. interventions such as cognitive enhancement ther-
apy have also been described to improve these
decits (9). However, these interventions can be
Discussion
time-intensive, requiring trained mental health
This is the rst study to explore the eect of yoga professionals. Yoga therapy is a popular alterna-
therapy on FERD. The results of this study show tive system of medicine, and resources to obtain
that yoga therapy as an add-on to antipsychotic this training are widely available in a developing
treatment can be benecial in improving positive country like India, where mental health resources
symptoms, negative symptoms, FERD, and socio- are sparse. After an initial training period, patients
occupational functioning. The results of this study can continue practice at home, which can reduce
support the ndings of an earlier study that dependence on mental health resources. Interest-
demonstrated yoga as an add-on therapy to benet ingly, benets of yoga therapy that occurred at the
several dimensions of outcome in schizophrenia (12). 2nd month of follow-up continued to persist even
Although there was a signicant dierence in at the 4th month. One genuine concern is the
negative symptoms and TRACS between groups at monitoring of yoga practice at home. Although
baseline, there was no signicant correlation patients and caregivers were instructed to maintain
between change in negative symptoms and a logbook of yoga practice, many of the patients
change in TRACS, suggesting that change in did not maintain the logbook as per our expecta-
negative symptoms alone might not have resulted tion. A longer duration of supervised yoga therapy
in improvement in emotion recognition scores. In by the trained yoga therapist may have produced
the Exercise and Waitlist groups, the negative more robust results.
symptoms and FERD did not improve, supporting Integration of conventional psychiatric treat-
the current understanding that these are residual ments with mind body practices is an emerging
decits in schizophrenia. The possibility of anti- eld. An example of this is the recent study that
psychotic medication confounding the results was integrated yoga breath intervention with exposure
minimized by ensuring stable antipsychotic dos- therapy in post-traumatic stress disorder and
ages for 68 weeks prior to study and throughout depression in survivors of Tsunami (17). Hence, it
the study duration. Hence, the nding of signi- is important that yoga therapists should receive
cant improvement in these parameters in antipsy- training in mental health disorders to sensitize
chotic-stabilized patients is of important clinical them to the needs of the psychiatric population.
relevance. The mental health professionals should work in
The correlation between FERD and socio-occu- close association with the yoga therapists, so that
pational functioning supports ndings of earlier they are readily available to handle the needs of the
studies (7). Impairment in facial emotion recogni- patients, if they may arise. In this context, it is
tion abilities can impair the ability to interact in interesting to note that in our study, none of the
150
Eect of yoga therapy on patients with schizophrenia
patients had worsening of positive symptoms 9. Hogarty GE, Flesher S. Practice principles of cognitive
during the duration of yoga therapy. Further, enhancement therapy for schizophrenia. Schizophr Bull
1999;25:693708.
none of the patients required increase in dose of 10. Behere RV, Venkatasubramanian G, Arasappa R, Reddy N,
antipsychotics. This probably suggests that yogas- Gangadhar BN. Eect of risperidone on emotion recog-
anas and breathing techniques can be practiced by nition decits in antipsychotic-naive schizophrenia: a
patients with schizophrenia without worsening of short-term follow-up study. Schizophr Res 2009;113:72
psychotic experiences. 76.
11. Kucharska-Pietura K, David AS, Masiak M, Phillips ML.
In conclusion, yoga as an add-on treatment Perception of facial and vocal aect by people with
improves positive and negative symptoms, and schizophrenia in early and late stages of illness. Br J Psy-
emotion recognition abilities in antipsychotic- chiatry 2005;187:523528.
stabilized patients with schizophrenia, which in 12. Duraiswamy G, Thirthalli J, Nagendra HR, Gangadhar BN.
turn might improve their socio-occupational func- Yoga therapy as an add-on treatment in the management
of patients with schizophreniaa randomized controlled
tioning. Further systematic studies are needed to trial. Acta Psychiatr Scand 2007;116:226232.
study the benecial eects of yoga in patients with 13. Kay SR, Opler LA, Lindenmayer JP. The Positive and
schizophrenia and their potential neurobiological Negative Syndrome Scale (PANSS): rationale and stan-
mechanisms. dardisation. Br J Psychiatry Suppl 1989;7:5967.
14. Saraswat N, Rao K, Subbakrishna DK, Gangadhar BN. The
Social Occupational Functioning Scale (SOFS): a brief
Acknowledgement measure of functional status in persons with schizophrenia.
Schizophr Res 2006;81:301309.
This study was supported by AYUSH grant awarded to Dr BN 15. Behere RV, Raghunandan VN, Venkatasubramanian G,
Gangadhar vide letter no. Z.31018/1/2006-Y&N/R&P(Ay)/ Subbakrishna DK, Jayakumar PN, Gangadhar BN.
EMR. The authors thank the anonymous reviewers for the TRENDS: a Tool for Recogniton of Emotions in Neuro-
thorough review of the manuscript that has helped immensely psychiatric DisorderS. Indian J Psychol Med 2008;30:
in improving the quality of the manuscript. 3238.
16. Hooker C, Park S. Emotion processing and its relationship
to social functioning in schizophrenia patients. Psychiatry
Declaration of interest Res 2002;112:4150.
There is no conict of interest to declare by any of the authors 17. Descilo T, Vedamurtachar A, Gerbarg PL et al. Eects of a
in relation to this manuscript. None of the authors are yoga breath intervention alone and in combination with an
associated with any pharmaceutical companies by way of exposure therapy for post-traumatic stress disorder and
being on speakers list of pharmaceutical companies, receiving depression in survivors of the 2004 South-East Asia tsu-
grants from industry or being members of pharmaceutical nami. Acta Psychiatr Scand 2010;121:289300.
advisory boards.
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Behere et al.
Shavasana (corpse posture) this involves progressively (3) Returning to position one
tensing all the muscles of the body in 15 s, relaxing all of
them instantaneously and staying relaxed for 45 s (4) Returning to position of attention
II C. Sitting posture asanas: Yoga therapy for the management of patients with schizo-
phrenia
II C.1. Vakrasana (twist posture) 30 s
III B. Position: attention
II C.2. Prasarita pada paschimatanasana (stretching of back
with stretched legs) 1 min (1) Raising the arms forward to the shoulder level, ngers
together
II C.3. Ustrasana (camel posture) 1 min
(2) Flinging arms sideward to the shoulder level, palms facing
II D. Prone posture asanas: the ground heel raise
II E. Supine posture asanas: (1) Stepping the left leg forward and raising the arms forward,
palms are kept facing each other and ngers are kept
II E.1. Sarvangasana (shoulder stand) 3 min together
II E.2. Matsyasana (sh posture) 1 min (2) Flinging arms sideward at the shoulder level, palms facing
the ground and lounging left leg forward
III Breathing exercises:
(3) Returning to position one
III A. Kapalabhati (cleansing breath exercise): 6080 rounds
2 min (4) Returning to position of attention
III B. Sectional (abdominal, thoracic, clavicular, and full III D. Position: attention
yogic) breathing: each ve rounds 4 min
(1) Raising arms forward to the shoulder level palms facing
III C. Nadi-shuddi pranayama (balancing breath): nine each other with the ngers together
rounds 2 min
(2) Raising the arms upward, palms facing each other and with
III D. Nadanusandhana (feeling of inner sound while chanting ngers together heels are raised
A, U, M) each nine rounds 10 min
(3) Returning to position one
IV Quick relaxation technique (QRT) 3 min. This involves
adopting Shavasana and three phases of observing (4) Returning to position of attention
abdominal movements, synchronizing them with deep
breathing, and feeling of energy and collapsing all the III E. Position: attention
muscles
(1) Raising arms sideward, shoulder level, palms facing the
ground, ngers together
Appendix B: Physical exercises: adopted from the National
Fitness Corps Handbook for Middle High and Higher Secondary (2) Squatting on toes, inging arms upwards, palms facing
Schools (29); duration: 1 h* each other
(1) Raising the arms forward to the shoulder level palms facing (2) Flinging arms upward above head with a clap and jumping
each other, ngers together feet together
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Eect of yoga therapy on patients with schizophrenia
(3) Returning to position one (2) Elbows bend, palms touching head
(1) Hands forward upward rise to shoulder level, palms facing IV B. Position: cross-legged sitting, hands slanting
each other, heels raise
(1) Hands sideward, upward, elbows bend, palms touch the
(2) Half squat, chest rm (hands bent at elbows) palm head
downward, middle ngers1 2 distance from each other
(2) Trunk bend, head downward
(3) Hands sideward raise, knees straight
(3) Same as 1
III H. Position: attention
(4) Back to position
(1) Hands forward raised, half-knee bent (no gap between
knees) IV C. Position: cross-legged sitting, hands slanting
(2) Back to position Chest rm (i.e. elbow bent palms downward and in front of
the chest)
(3) Hands sideward raised, half-knee bent
(1) Elbows backward press (chest expanding action)
(4) Back to position.
(2) Hands forward sideward backward press
IV. Sitting posture exercises 20 min
IV D. Position: cross-legged sitting, hands sideward slanting.
IV A. Position: cross-legged sitting, hands slanting 13: hands upward, downward swing, clap over head
(1) Hands rise over had slowly without bending at elbows, *The therapist would give 2 min time in between the dierent
palms touching each other, ngers extended upward exercises with a non-specic instruction, just relax now.
153