G.

Celine Han, PhD

Postdoctoral Fellow, Harvard Medical School, Dana-Farber Cancer Institute, Broad Institute
(814)-880-4939 | celinegaram@gmail.com | 156 Fisher Avenue, Boston, MA 02120

SUMMARY OF QUALIFICATIONS
PhD in computational biology & bioinformatics with commanding skills in integrative analyses of molecular-biology data for
discovering cellular mechanisms for responding/resisting cancer therapies, biomarker discovery and patient stratification.
Extensive experience in integrative analyses of genomics (Whole Exome Sequencing), transcriptomics (RNA-seq),
epigenetics (ChIP-seq/ ChIP-exo), clinical information of patient samples, and preclinical functional data.
Proven skills in communication, presentation and leadership, spearheading collaborative projects by leading
multidisciplinary teams in clinics and computation.

RESEARCH EXPERIENCE
Postdoctoral Research Fellow August 2015-Present
Dana-Farber Cancer Institute, Broad Institute, Harvard Medical School, Boston MA
Lab of Dr. Eliezer Van Allen emphasizes translational science with immediate potential clinical applications using computational
cancer genomics, massively parallel sequencing applied to precision cancer medicine, and resistance to cancer therapeutics.
Performed systematic genomic and functional studies to elucidate cellular pathways perturbed by genomic alterations in
metastatic prostate cancer patients who exhibit a spectrum of responses and resistance to androgen deprivation therapy
(abiraterone and enzalutamide) for patient stratification and prioritization of combined therapies.
Demonstrated the activation of cell cycle genes as a key biomarker for enzalutamide resistance in androgen deprived
prostate cancer. This study has immediate clinical trial implications toward combined therapy of cell cycle inhibitors to
enzalutamide resistant patients.
Launched project for prioritizing oncogenic drivers using allele-specific expression through mutation analyses of RNA-seq.
Directed team of software developers to implement and upgrade existing RNA-seq mutation calling methods by
incorporating QC and statistical measures.
Orchestrated research among clinical research coordinators and radiologists to collect and interpret patient information
Partnered with preclinical experimental lab (Dr. William Hahns lab) for functional validation.
Participated in projects funded by National Cancer Institute (NCI), National Institute of Health (NIH), Stand Up to Cancer
(SU2C)-Prostate Cancer Foundation (PCF) Dream Team. Collected patient samples from 5 clinical sites of SU2C-PCF and
conducted quality control analyses of sequencing data.
Represented research progress for Dana-Farber clinical site at SU2C-PCF Progress Review Team Visit.
Authored total 7 co-authored publications, including 1 first-author publication.

Graduate Research Assistant Pennsylvania State University, State College, PA August 2009-May 2015
Co-advised by Drs. Frank Pugh and Ross Hardison to study the transcriptional regulation in erythropoiesis in mouse by
examining binding locations of key transcription factors, GATA1 and TAL1.
Participated as a member of the ENCODE (The Encyclopedia of DNA Elements) Project.
Developed and completed the computational analysis pipeline for analyzing ChIP-exo (Chromatin Immunoprecipitation,
exonuclease treatment, then sequencing) data using programming languages (Python, R and Linux) and visualization tools.
Collaborated and consulted with biologists and colleagues as a scientific resource for computational analyses.
Composed and developed tutorials and user-manuals for computational tools

EDUCATION
Ph.D. in Integrative Biosciences (IBIOS) - Pennsylvania State University 2008-2015
Bioinformatics and Genomics (BG) Option

B.S. in Science - Pennsylvania State University 2004-2008

Life Science Option
G. Celine Han PhD Resume Page 2 of 3

SKILLS AND TECHNIQUES
Next Generation Sequencing Data Analysis: Cancer genomic analysis (Firehose), Whole exome sequencing (mutation
calling and copy number alterations), RNA-seq (mutation calling, expression, fusion) and Epigenetic data analyses
(methylation, ChIP-exo and ChIP-seq, peak calling, motif discovery).
Biological Data Visualization: Cytoscape (Systems biology, network analysis) and PyMOL (molecular graphics).
Programming Languages & Computer Skills: Python, R, Shell/Bash, Unix environment, and Adobe Illustrator
Experimental Laboratory Experience:
o Certificate for Techniques in Molecular Biology Laboratory Workshop, May 2015, Penn State University
o Chromatin immunoprecipitation and exonuclease (ChIP-exo), Nucleic acid purification, Restriction enzyme
digestion, Gel electrophoresis, Southern and northern hybridizations, Generating nucleic acid probes, Cloning and
screening, DNA sequencing, PCR amplification, Western blot and Tissue cell culture.
Languages: Bilingual in English and Korean.

MENTORING & TEACHING EXPERIENCE

Certificate in College Teaching Pennsylvania State University Spring 2015

Graduate Teaching Assistant Pennsylvania State University

BMB 252H Introduction to Cell & Molecular Biology for Honors students Spring 2012
o Co-designed course syllabus, gave lectures on various topics (Cell Cycle & regulation, Apoptosis, Cancer,
Stem Cell Biology, Cell Signaling, Cytoskeleton, etc.). Designed exam questions, graded homework, quizzes,
and exams. Led class discussions, advised students with class presentations and office hours.
IBIOS 496 Introduction to Genomics for Graduate Students Fall 2010
o Graded homeworks, advised students during office hours, and facilitated class discussions.
o Gave a lecture on Analyzing Next Generation Sequencing (NGS) data through Web-based Tools: GALAXY,
BLAST, ClustalW. Han GC and Park BS. October 2010.

ACADEMIC SERVICES
Leadership
Officer and Webmaster - Sigma Delta Epsilon Graduate Women in Science (GWIS) Chapter 20102011
o Managed GWIS website (HTML and Dreamweaver) and database
o Provided computational support and organization support for GWIS staffs and leaders
Founding member and Coordinator - Penn State Bioinformatics Korean Group at Penn State 20102013

Professional Roles
Scientific Program Committee - Translational Bioinformatics Conference (TBC) 2017 2017Present
Korean American Society in Biotech and Pharmaceuticals (KASBP) Member 2017Present
American Association for Cancer Research (AACR) Associate Member 2015Present
Stand Up To Cancer (SU2C)/Prostate Cancer Foundation (PCF) Dream Team Research Team Member 20152017
New England Bioscience Society (NEBS) Member 2015Present
International Society for Computational Biology (ISCB) Member 2013-2015

Reviewer Experience
BioMed Research International 2016
Biochimica et Biophysica Acta (BBA) General Subjects 2016
Hindawi Publishing Corporation 2015
Book chapters in Big Data Analytics in Bioinformatics and Healthcare 2014
o Edited by Wang, Li and Perrizo, Medical Information Science Reference, Hershey, PA
G. Celine Han PhD Resume Page 3 of 3

SELECTED TALKS, POSTER PRESENTATIONS AND CONFERENCES
1. Invited talk at University of Massachusetts Medical School. Drivers, response & resistance to therapy using integrative
molecular profiling of patient tumors. September 2017, Worcester, MA
2. Poster presentation. Han G.C., et al. Genomic resistance patterns to second-generation androgen blockade in paired
tumor biopsies of metastatic castrate-resistant prostate cancer. American Association for Cancer Research (AACR), March
2017, Washington DC
3. Invited talk at Stand Up To Cancer (SU2C)-Prostate Cancer Foundation (PCF) 30 Month Progress Review Team Visit.
Precision Therapy of Advanced Prostate Cancer: Post-Abiraterone and Post-Enzalutamide Changes on Paired Samples.
July 2016. Chicago, IL.
4. Invited talk at Festival of Genomics. Integrative genomic profiling of patient tumors: drivers, targets & response to therapy.
June 2016. Boston, MA
5. Invited talk at the Center for Eukaryotic Gene Regulation. A Comprehensive Genome-wide binding of GATA1 and TAL1
during Erythroid Development via High Resolution ChIP-exo. November 2013, University Park, PA.
6. Student talk at 3rd Bioinformatics and Genomics Retreat. Insights into Transcriptional Regulation of Erythropoiesis via High
Resolution ChIP-exo. September 2013, University Park, PA.
7. Poster presentation. Han G.C., Hardison R.C., Pugh B.F. A Comprehensive and High Resolution Genome-wide binding of
GATA1 and TAL1 during Erythroid Development. Cold Spring Harbor Lab (CSHL) Conference on The Biology of Genomes,
May 2013, Cold Spring Harbor, NY.
8. Invited lecture and workshop at National Human Genome Research Institute (NHGRI)-funded event, "Exploring DNA with
Penn State". Gave lecture and coordinated workshops on molecular basics of DNA, and human genome project to high
school students from 5 school districts of Pennsylvania. Han GC and Rossi M. May 2012, University Park, PA.

PUBLICATIONS
1. Han GC, Hwang J, Mullane SA, Zhang Z, Liu D, Cibulskis C, Gaviola GC, Ghazikhanian V, McKay RR, Bubley GJ, Carter
SL, Balk SP, Hahn WC, Taplin ME, Van Allen EM. Genomic resistance patterns to second-generation androgen blockade in
paired tumor biopsies of metastatic castrate-resistant prostate cancer (In press, JCO Precision Oncology)
2. Botta G, Golomb L, Rabasha B, Han GC, Mullane SA, et al., Goetz EM, Corey E, Van Allen EM, Root D, Doench J,
Garraway LA. Loss of INPP5A Confers Resistance to Androgen Deprivation Therapy in Prostate Cancer (Submitted to JCI
Insight)
3. AlDubayan SH, Giannakis M, Moore N, Mu XJ, Han GC, Hamada T, et al. Garraway LA, Ogino S, Fuchs CS, Van Allen EM,
Inherited Homologous Recombination Deficiency in Colorectal Cancer (In review, JAMA)
4. Liu D, Abbosh P, Keliher D, Reardon B, Miao D, Mouw K, Weiner-Taylor A, Mullane SA, Han GC, et al. Garraway LA, Getz
G, Carter SL, Bellmunt J, Plimack ER, Rosenberg JE, Van Allen EM, Mutational Patterns in Chemotherapy Resistant
Muscle-Invasive Bladder Cancer (Revision, Nature Communications)
5. Armenia J, Mullane SA, Liu D, Gao J, Kundra R, Reznik E, Chatila WK, Chakravarty D, Han GC, Coleman I, et al, Kantoff
PW, Taplin ME, Abida W, Taylor BS, Scher HI, Nelson PS, de Bono JS, Rubin MA, Sawyers CL, Chinnaiyan AM, PCF/SU2C
International Prostate Cancer Dream Team, Schultz N, Van Allen EM. The long tail of oncogenic drivers in prostate cancer
(In review, Nature Genetics)
6. Taylor-Weiner A, Zack T, O'Donnell E, Guerriero JL, Bernard B, Reddy A, Han GC, AlDubayan S, Amin-Mansour A,
Schumacher SE, Litchfield K, Turnbull C, Gabriel S, Beroukhim R, Getz G, Carter SL, Hirsch MS, Letai A, Sweeney C, Van
Allen EM. Genomic evolution and chemoresistance in germ-cell tumours. Nature. 2016 Nov 30;540(7631):114-118. doi:
10.1038/nature20596. PMID: 27905446
7. Pritchard CC, Mateo J, Walsh MF, De Sarkar N, Abida W, Beltran H, Garofalo A, Gulati R1, Carreira S, Eeles R, Elemento
O, Rubin MA, Robinson D, Lonigro R, Hussain M, Chinnaiyan A, Vinson J, Filipenko J, Garraway L, Taplin ME, AlDubayan
S, Han GC, et al. Van Allen E.M., Offit K., de Bono J., Nelson P.S. Inherited DNA Repair Gene Mutations in Men with
Metastatic Prostate Cancer. N Engl J Med. 2016 Aug 4;375(5):443-53. doi: 10.1056/NEJMoa1603144. PMID: 27433846
8. Han GC, et al. Genome-wide organization of GATA1 and TAL1 determined at high resolution. Molecular and Cellular
Biology. 2015 Oct 26;36(1):157-72. doi: 10.1128/MCB.00806-15. PMID: 26503782

RELEVANT TRAINING
Selected participant at AACR Translational Cancer Research for Basic Scientist Workshop, September 2016, Boston, MA