Global Acute Myeloid Leukemia (AML) Treatment Market US$ 1.

17 Billion 2021

The global acute myeloid leukemia treatment market expected to reach US$ 1.17 billion by 2021, growing at CAGR
15% over the forecast period 2017-2021, owing to introduction of high-priced products and strong pipeline of
upcoming drugs. During the forecast period, the marketed drugs, pipeline drugs and others are predicted to
contribute 55%, 35%, and 10% market share of the global acute myeloid leukemia drugs market, respectively.

Acute myeloid leukemia (AML) is the second most common type of leukemia diagnosed in adults and children. In
2017, in the United States, an estimated 21,380 people will be diagnosed with AML. Most patients with newly
diagnosed AML are offered the combination of standard-dose cytarabine with an anthracycline (daunorubicin or
idarubicin) regimen, whereas those with adverse-risk disease are offered allogeneic stem-cell transplant (SCT) in first
remission. The treatment of AML is divided into categories based on their mechanisms of action: cytotoxic agents,
small-molecule inhibitors, and targeted therapies. These drug candidates range from cytotoxic chemotherapies,
targeted small-molecule inhibitors, and monoclonal antibodies. Currently available hypomethylating agents
azacitidine and decitabine are FDA-approved for use in the United States. Tyrosine kinase inhibitors (TKIs) or FLT3
inhibitors, such as midostaurin (Rydapt) were developed as targeted therapies that interferes with aberrant tyrosine
kinase activation in malignant cells.

Chemotherapy is the major form of remission induction therapy for acute myeloid leukemia. Some of the other
chemo drugs that may be used to treat AML include: Cladribine (Leustatin), Fludarabine (Fludara), Topotecan,
Etoposide (VP-16), 6-thioguanine (6-TG), Hydroxyurea (Hydrea), Corticosteroid drugs, such as prednisone or
dexamethasone (Decadron), Methotrexate (MTX), 6-mercaptopurine (6-MP), Azacitidine (Vidaza), and Decitabine
(Dacogen). Arsenic trioxide (Trisenox) and all-trans retinoic acid (ATRA) are anti-cancer drugs that can be used alone
or in combination with chemotherapy for remission induction of a certain subtype of AML called promyelocytic
leukemia. A stem cell transplant or bone marrow transplant, may be used for consolidation therapy. In 2017, the
U.S. Food and Drug Administration approved Rydapt (midostaurin) as a target therapy for the treatment of adult
patients with newly diagnosed acute myeloid leukemia. There are several promising drug currently in the phase III
pipeline include chemotherapy drugs such as CC-486, Guadecitabine (SGI-110), Liposomal cytarabine daunorubicin
(Vyxeos), Sapacitabine, Vosaroxin (Qinprezo), fixed-combination drugs such as AG-221, Ganetespib, Idasanutlin,
Vadastuximab talirine (SGN-CD33A), and kinase inhibitor candidates such as Gedatolisib, Gilteritinib, Midostaurin,
Quizartinib, and Volasertib.

Visit Acute Myeloid Leukemia Treatment Market by Drug Type - Hypomethylating Agents - Vidaza (Azacitidine),
Dacogen (Decitabine), Cytarabine-based Chemotherapy Drugs, Others; by Pipeline Analysis (Phase III Drugs) -
Chemotherapy Drugs, Vyxeos (Fixed-combination Drugs: Daunorubicin and Cytarabine); Kinase Inhibitors
(Midostaurin, Quizartinib) and Forecast 2017-2021. The global acute myeloid leukemia treatment market research
report provides market size (Revenue USD Million 2014 to 2021), market share analysis, growth trends and forecast
(CAGR%, 2017 to 2021). The global acute myeloid leukemia treatment market research report is further segmented
by geography into North America (U.S., Canada), Latin America (Brazil, Mexico, Rest of LA), Europe (U.K., Germany,
France, Italy, Spain, Rest of EU), Asia Pacific (Japan, China, India, Rest of APAC), and Rest of the World. In addition,
the global acute myeloid leukemia treatment market report provides the detailed market landscape (market drivers,
restraints, opportunities), market attractiveness analysis, and market profitability analysis by key products and
regions or countries. The report also tracks the major competitors operating in the global market by company
overview, financial snapshot, major products, technologies, services offered and recent developments. Major
players operating in the global acute myeloid leukemia treatment market and profiled in this report include Astellas
Pharma, Astex Pharmaceuticals, Bayer, Boehringer Ingelheim, Celgene (AgiosCelgene), Cyclacel Pharmaceuticals,
Daiichi Sankyo, Jazz Pharmaceuticals, Novartis, Onyx Pharma, Otsuka Pharmaceuticals, Pfizer, Roche, Seattle
Genetics, Sunesis Pharmaceuticals, and Synta Pharmaceuticals.

1. Drug Type
1.1. Hypomethylating Agents
1.1.1. Vidaza (Azacitidine)
1.1.2. Dacogen (Decitabine)
 1.2. Cytarabine-based Chemotherapy Drugs
1.3. Others

2. Pipeline Analysis (Phase III Drugs)

2.1. Chemotherapy Drugs
2.2. Vyxeos (Fixed-combination Drugs: Daunorubicin and Cytarabine)
2.3. Kinase Inhibitors
2.3.1. Midostaurin
2.3.2. Quizartinib

3. Geography
3.1. North America (U.S., Canada)
3.2. Latin America (Brazil, Mexico, Rest of LA)
3.3. Europe (U.K., Germany, France, Italy, Spain, Rest of EU)
3.4. Asia Pacific (Japan, China, India, Rest of APAC
3.5. Rest of the World

4. Company Profiles
4.1. Astellas Pharma
4.2. Astex Pharmaceuticals
4.3. Bayer
4.4. Boehringer Ingelheim
4.5. Celgene (AgiosCelgene)
4.6. Cyclacel Pharmaceuticals
4.7. Daiichi Sankyo
4.8. Jazz Pharmaceuticals
4.9. Novartis
4.10. Onyx Pharma
4.11. Otsuka Pharmaceuticals
4.12. Pfizer
4.13. Roche
4.14. Seattle Genetics
4.15. Sunesis Pharmaceuticals
4.16. Synta Pharmaceuticals

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