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100 0037-198X/08/$-see front matter 2008 Elsevier Inc. All rights reserved.
doi:10.1053/j.ro.2008.01.005
Figure 1 Normal axial anatomy on 64-slice CT coronary angiography at 0.625-mm collimation. AIVS anterior
interventricular septum; Ao aortic root; AV atrioventricular; Diag diagonal; LA left ventricle; LV left
ventricle; LAD left anterior descending; LM left main; LCX left circumflex; OM obtuse marginal; PDA
posterior descending coronary artery; PLB posterolateral branch; RA right atrium; RV right ventricle; RCA
right coronary artery. (A) LM arising from the left sinus of Valsalva and giving rise to the LAD and LCX. (B) LAD and
LCX, a couple of centimeters from the bifurcation of the LM. The LAD runs in the AIVS alongside the anterior
interventricular vein. (C) RCA arising a little caudally from the anterior right sinus of Valsalva. Note the LAD giving rise
to the diagonal. The LCX is just about to enter the posterior atrioventricular groove. (D). RCA in the anterior AV groove,
the OM along the lateral margin of the heart, and the distal LAD in the AIVS. (E) The mid RCA at the acute margin of
the heart, the PLB, a branch of the distal RCA crosses the crux of the heart and runs in the left posterior AV groove.
(F) The horizontal portion of the distal RCA is seen in the posterior right AV groove. The PDA came off the RCA and
is running in the posterior interventricular septum alongside the middle cardiac vein.
102 S. Patel
Figure 2 Normal RCA at selective coronary catheterization (A) on curved reformat (B) volume-rendered (C) and 3-D VR
coronary tree image 64-slice CT (D). (Color version of figure is available online.)
Anatomy of the coronary arteries 103
Figure 7 LAD and LCX: (A) Selective injection of the left coronary at cardiac catheterization demonstrates the LAD and
LCX and their branches. (B) Curved reformat of the LAD which courses down to the apex of the heart. (C) Oblique MIP
of the LAD and its branches, the septal perforators and the diagonals. (D) Curved reformat of the LCX as it courses in
the posterior AV and gives rise to a large OM. (E) 3-D VR image demonstrates the epicardial surface anatomy of the LAD
and LCX as they arise from the LM bifurcation. The LAD runs in the anterior interventricular groove and gives of
diagonal branches, the LCX runs in the posterior AV groove and gives rise to a large OM. (F) 3-D VR coronary tree image
of the LM, LAD, LCX and their branches. (Color version of figure is available online.)
Segmental Anatomy either the first septal perforator or the first diagonal; the
For segmental anatomy of the coronary arteries different no- mid segment from that point to the second diagonal and
menclatures developed and modified by the American Heart the distal segment is from that point distally.
Association can be used.5,6 Although the numbering of the LCX: proximal segment is from the origin to the first ob-
segments is commonly used for research purposes, these no- tuse marginal, and the distal segment is distal to that
menclatures are referred to when analyzing and reporting point.
coronary CT examinations. The RCA, LAD, and LCX coro-
nary arteries are divided into the proximal, mid, and distal
segments as follows: Coronary Artery Anomalies
RCA: proximal segment from the ostium to the acute mar- Anomalies of the coronary arteries are rare, occurring in 1.3%
ginal, mid segment is the one that curves around the (range 0.3-5.64%) of the population.7 They are often an
acute margin of the heart and the distal segment runs incidental finding in asymptomatic patients. Approximately
along the posterior right AV groove. 20% of coronary anomalies may have a life-threatening pre-
LAD: proximal segment from the origin of the LAD to sentation, including myocardial infarction, arrhythmia, or
Anatomy of the coronary arteries 105
Figure 8 3D volume-rendered CT demonstrating the PDA and PLB Figure 10 Retroaortic course: Axial oblique MIP demonstrating the
branches arising from the LCXa left dominant system. Note a LM arising from the right sinus of Valsalva and taking a retroaortic
large OM arising from the LCX. (Color version of figure is available course between the aortic root (Ao) and the left atrium (LA). Note
online.) the RCA has stents.
106 S. Patel
the origin and proximal anatomic course, but also the pres-
ence of any atherosclerotic disease within that artery.
Coronary anomalies can generally be divided into anoma-
lies of origin and course, anomalies of intrinsic coronary ar-
terial anatomy, and anomalies of termination.7,13-16
Figure 13 Transeptal course. (A) An axial 5-mm MIP demonstrating the LAD originating from the right sinus of Valsalva
and taking a subpulmonic course as the dives down into the interventricular septum. (B) A sagittal reformat demon-
strates the intramyocardial course of the LAD in the proximal septum before. (C) Traversing back to the epicardial
surface of the heart more distally and is surrounded by epicardial fat.
erosclerotic disease prematurely affects the ret- pulmonary artery or right ventricular outflow tract.
roaortic LCX and is more severe.21 This anomaly may often be seen in patients with
d. Prepulmonicis a nonmalignant course that Tetralogy of Fallot.22
does not compromise flow. The involved coronary iii. Anomalous origin of the coronary artery from the pul-
artery, usually the LM, LAD, or LCX, courses ante- monary artery (Fig. 14): A rare but lethal anomaly
rior to the pulmonary artery or right ventricular presents in early infancy with an incidence of 1 in
outflow tract (Fig. 11). The prepulmonic segment 300.000 live births.13 Extensive collaterals develop be-
of the artery is long as it courses anterior to the tween the right and left coronary arterial systems and
Figure 14 Coronary artery arising from the pulmonary arteryaxial CT. (A) The LM is dilated as it arises from the LSV.
Note the dilated RCA in the anterior AV groove at a higher location than normal. Multiple collateral vessels are seen
(arrows); these were between the right and left coronary arterial systems. (B) The RCA arises from the pulmonary artery.
Note a large bronchial artery collateral from the descending thoracic aorta (arrowheads).
108 S. Patel
Figure 19 Myocardial bridging. (A) Curved reformat of the LAD demonstrates a long segment of the mid LAD demon-
strating an intramyocardial course (arrowheads). (B) On the cross-sectional orthogonal MIP view the tunneled artery
(arrow) is surrounded by muscle.
ization.29 The involved coronary artery is dilated and spectively. When the coronary artery does not arise from its
may have a single (most common) or multiple com- respective sinus, evaluate the opposite or noncoronary sinus
munications at its distal drainage site.28 Most fistulae for possible anomalous origin of a coronary artery. The
arise from the RCA and drain into the right heart course of each coronary artery should then be followed in
chambers. The right ventricle is the most common turn, to determine whether it follows a normal or anomalous
site of drainage followed by the right atrium, coro- course (interarterial, transeptal, prepulmonic, or retroaortic).
nary sinus, and the pulmonary artery. A small fistula It is usually the proximal portion of the artery that follows an
may be of no consequence, whereas a large fistula anomalous course; the distal distribution is normal. Maxi-
may increase in size over time and may have a serious mum intensity projection (MIP) images are useful in evaluat-
clinical outcome, due to myocardial steal phenome- ing the number of ostia, the anatomic course, particularly the
non or decreased myocardial blood flow distal to the intramyocardial course or transeptal course, as well as the
fistulous connection, arrhythmias, congestive heart intramural portion of the coronary artery which on cross-
failure, or aneurysm formation. section views may appear oval, slit-like, or round. The caliber
b. Extracardiac termination: rarely, the coronary arteries of the anomalous coronary artery can also be better evaluated
may terminate in extracardiac vessels such as bron- on the MIP views and compared with the caliber of the distal
chial, internal mammary, phrenic, or intercostals vessel. The interarterial or transeptal portion of an anomalous
arteries. vessel may be of smaller caliber when compared with the
vessel distal to this area. Volume-rendered images are useful
to evaluate the origin (sinus versus opposite coronary artery)
Image Analysis and the number of ostia as well as the epicardial course of the
and Interpretation coronary arterieswhich is exquisitely depicted in some pa-
It is important to review each coronary artery in a systematic tients (Figs. 11 and 17). The shape and number of ostia are
fashion from origin to termination. A lot of information can also well seen on endoluminal views. Besides evaluating the
be gathered from the axial source images (Fig. 1). When origin, course, and caliber of the anomalous vessel, it is im-
scrolling through the axial images, the left coronary ostium is portant to analyze the vessel for atherosclerotic disease caus-
visualized cranial to the RCA ostium, predominantly in the ing luminal stenosis due to calcified, noncalcified, or mixed
middle to top half of the left coronary sinus. On axial images, plaque.
the right ostium is seen caudal to the left coronary artery
origin as it arises from its respective sinus. Evaluation should
include assessment of ostial location within the respective
Conclusion
sinus/opposite sinus, ostial location above the sinotubular This article has reviewed the normal anatomy of the coronary
ridge (high-takeoff), ostial configuration (round, oval, or slit- arteries that every physician should be familiar with when
like), and number of ostia from the left and right sinus, re- interpreting coronary CT examinations. The article also re-
Anatomy of the coronary arteries 111
Figure 20 Coronary artery fistula (CAF). (A) 3D volume-rendered tree image demonstrates a small fistulous connection
from the LAD that terminated in the pulmonary artery. (B). 3D volume-rendered of the heart demonstrates the surface
anatomy of the coronary artery fistula from the LAD to the pulmonary artery. (Color version of figure is available
online.)
views the common and uncommon coronary artery anoma- 7. Angelini P: Coronary artery anomalies current clinical issues: defini-
lies and their prevalence. While rare, these coronary artery tions, classification, incidence, clinical relevance, and treatment guide-
lines. Tex Heart Inst J 29:271-278, 2002
anomalies can potentially cause symptoms in a small number 8. Datta J, White CS, Gilkeson RC, et al: Anomalous coronary arteries in
of patients and are often fatal. It is therefore important to adults: depiction at multi-detector row CT angiography. Radiology
recognize the anomalies and be aware of their significance. 235:812-818, 2005
9. Fedak PW, Verma S, David TE, et al: Clinical and pathophysiological
implications of a bicuspid aortic valve. Circulation 106:900-904, 2002
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