Volume 548 Number 7668 pp371-49

24 August 2017
A randomized synbiotic trial to prevent sepsis among infants in rural India Pinaki Panigrahi, Sailajanandan
Parida, Nimai C. Nanda, Radhanath Satpathy, Lingaraj Pradhan, + et al.
A synbiotic preparation of Lactobacillus plantarum and fructooligosaccharide was found to
significantly reduce sepsis and infections of the lower respiratory tract in a trial involving
newborns from rural India.

Correction of a pathogenic gene mutation in human embryos Hong Ma, Nuria Marti-Gutierrez, Sang-Wook
Park, Jun Wu, Yeonmi Lee + et al.
CRISPRCas9 genome editing is used to induce a DNA repair response and correct a disease-
causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair
using the wild-type copy of the gene.

The primed SNAREcomplexinsynaptotagmin complex for neuronal exocytosis Qiangjun Zhou, Peng
Zhou, Austin L. Wang, Dick Wu, Minglei Zhao, + et al.
An atomic model of the primed pre-fusion SNAREcomplexinsynaptotagmin-1 complex in
neuronal exocytosis accounting for vesicle priming and cooperation in synchronizing and activating
evoked release on the sub-millisecond timescale.

Volume 548 Number 7667 pp259-366

17 August 2017
New gliding mammaliaforms from the Jurassic Qing-Jin Meng, David M. Grossnickle, Di Liu, Yu-Guang Zhang, April
I. Neander + et al.
Maiopatagium, a haramiyid from the Jurassic Tiaojishan Formation (around 160million years ago)
of China was specialised for gliding with a patagium (wing membrane) and a fused wishbone,
reminiscent of that of birds.

Integrative clinical genomics of metastatic cancer

Dan R. Robinson, Yi-Mi Wu, Robert J. Lonigro, Pankaj Vats, Erin Cobain + et al.
Clinical exome and transcriptome sequencing of 500 adult patients with metastatic solid tumours
of diverse lineage and biopsy site, as part of the Michigan Oncology Sequencing (MI-ONCOSEQ)
Program.

Volume 548 Number 7666 pp135-254

10 August 2017
New infant cranium from the African Miocene sheds light on ape evolution Isaiah Nengo, Paul Tafforeau,
Christopher C. Gilbert, John G. Fleagle, Ellen R. Miller + et al.
Description of the most complete fossil skull of an infant ape recovered from the Miocene epoch
of Kenya, assigned to a new species in the genus Nyanzapithecus.

The complete connectome of a learning and memory centre in an insect brain Katharina Eichler, Feng Li,
Ashok Litwin-Kumar, Youngser Park, Ingrid Andrade + et al.
The complete, synapse-resolution connectome of the Drosophila larval mushroom body.
Volume 548 Number 7665 pp5-130
3 August 2017
Hypothalamic stem cells control ageing speed partly through exosomal miRNAs Yalin Zhang, Min Soo Kim,
Baosen Jia, Jingqi Yan, Juan Pablo Zuniga-Hertz + et al.
Ablation of hypothalamic stem/progenitor cells in mice leads to ageing-related decreases in
physiological parameters and lifespan, and the speed of ageing is partially controlled by these cells
through the release of exosomal miRNAs.