DEPARTMENT OF PHARMACOLOGY, KIMS, Model questions THEORY

LONG ESSAYS

1. Mention the different generations of Cephalosporins, their antibacterial spectrum

and routes of administration. Discuss the therapeutic uses of Third generation
Cephalosporins. Add a note on the prophylaxis and treatment of Bacterial
meningitis.

2. Classify the Antitubercular drugs. Mention the mechanism of action and adverse
effects of the standard antitubercular drugs. Discuss the various regimes used for
the short course chemotherapy of Tuberculosis.

3. Name the Broad spectrum Antibiotics. Discuss the antimicrobial spectrum,

mechanism of action, adverse effects, therapeutic uses and contraindications for
Tetracyclines.

4. Classify the Antiretroviral drugs. Explain the mechanism of action and adverse
effects of drugs from each group. Add a note on the management of various
opportunistic infections in AIDS patients.

5. Classify the Antimalarial drugs based on their chemical group as well as their
action in relation to life cycle of the malarial parasite. Discuss the mechanism of
action, adverse effects and therapeutic uses of Chloroquine. Add a note on the
treatment of Chloroquine resistant falciparum malaria.

6. Classify the Anticancer drugs. Mention the cell cycle specific drugs. Discuss the
mechanism of action, adverse effects and therapeutic uses of alkylating agents.

7. Discuss the biosynthesis, biological actions and therapeutic uses of Thyroid

Hormones. Add a note on the management of Myxoedema coma.

8. Classify the Antithyroid drugs. Discuss the mechanism of action, adverse effect
and indications of Thioamide drugs. Add a note on the management of Thyrotoxic
crisis.

9. Classify the Antidiabetic drugs. Discuss the metabolic actions and adverse effects
of Insulin. Add a note on the management of Diabetic coma.

10. Classify the Glucocorticoids. Discuss their adverse effects and therapeutic uses.

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11. Classify the Hormonal contraceptives. Discuss the mechanism of action and
adverse effects and collateral benefits of combined oral contraceptive pills. Add a
note on post coital contraception.

12. Classify the drugs used in Peptic ulcer. Discuss the pharmacological actions;
adverse effects and therapeutic uses of Proton pump inhibitors. Add a note on the
management of H.Pylori infection.

13. Classify the Antiemitic drugs. Discuss the mechanism of action, adverse effects
and therapeutic uses of Pro-kinetic drugs.

14. Classify the Antifungal drugs. Discuss the mechanism of action, adverse effects
and therapeutic uses of Imidazole antifungal drugs. Add a note on the management
of Cryptococcal Meningitis.

15. Classify the drugs used in Amoebiasis. Discuss the antimicrobial spectrum,
mechanism of action, adverse effects and therapeutic uses of Metronidazole.

16. Classify the Antiviral drugs. Discuss the mechanism of action, pharmacokinetics
and therapeutic uses of Acyclovir.

17. Name the Antimetabolites. Discuss the mechanism of action, adverse effects and
therapeutic uses of Methotrexate.

18. Name the Macrolide antibiotics and explain their mechanism of action. Mention
the antimicrobial spectrum, adverse effects and therapeutic uses of any one of
them.

19. Name the Aminoglycoside antibiotics and explain their mechanism of action.
Discuss the antimicrobial spectrum, pharmacokinetics and uses of Gentamicin.

20. Discuss the various mechanisms of antimicrobial resistance with suitable

examples. What are the measures and precaution to be taken to prevent or
minimize drug resistance in microorganisms.

21. Name the components of cotrimoxazole and explain the rationale of the
combination. Discuss its antimicrobial spectrum, adverse effects and therapeutic
uses.

22. Discuss the chemotherapy and prophylaxis of urinary tract infections.

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23. Enumerate fluroquinolones. Explain their mechanism of action and adverse
effects. Discuss the antimicrobial spectrum and therapeutic uses of the second
generation of fluroquinolones.

24. Discuss the various mechanisms of antimicrobial resistance with suitable

examples. What are the measures and precautions to be taken to prevent or
minimize the same.

25. Discuss the drugs that alter uterine contractility and their therapeutic applications.

26. Discuss the pharmacological factors influencing the calcium metabolism and their
therapeutic application. Out line the management of osteoporosis.

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SHORT NOTES.

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1. Somatostatin. 31. Tamoxifen
2. Radioactive Iodine. 32. Carbapenems
3. Insulin resistance. 33. Superinfection
4. Sweetening agents. 34. Antibiotic prophylaxis for surgery
5. Metformin. 35. Thiazolidine Antidiabetic drugs
6. Mupirocin. 36. 5-alpha reductase inhibitors.
7. Albendazole. 37. Drugs used for Endometriosis.
8. Spiramycin. 38. Tocolytic agents.
9. PUVA therapy. 39. Ribavirin.
10. Insulin analogues. 40. Hydroxyurea.
11. Sunscreening agents. 41. Alpha glucosidase inhibitors.
12. Praziquantel. 42. Inhalation Glucocorticoids.
13. Drugs used for Filariasis. 43. Drugs used for anaerobic infections
14. Anthracycline antibiotics. 44. Obstetrical uses of Prostaglandins
15. Treatment of Lepra reaction. 45. Streptogramins
16. Keratolytic agents. 46. Drugs used for inflammatory bowel disease
17. Mifepristone. 47. Adverse effects of Aminoglycosides
18. Beta lactamase inhibitors. 48. Prophylactic uses of Benzyl Penicillin
19. Ovulation inducing agents. 49. Antipseudomonal Penicillin
20. Antiandrogens. 50. Treatment of Acne Vulgaris
21. Biphosphonates. 51. Urinary antiseptics
22. Linezolid. 52. Biological response modifiers
23. Glycopeptide antibiotics. 53. Treatment of chlamydial urethritis
24. Antimotility drugs 54. Drugs used for CML
25. Clindamycin. 55. DMARDs
26. Lactulose. 56. GnRH analogues
27. Cyclosporin 57. Penicillamine
28. DOTS 58. Dimercaprol
29. Cisplatin 59. Ondansetron
30. Bulk Laxatives 60. Protease inhibitors
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