*** ACCELERATED *** Rituximab infusion to infuse over to infuse over

for cycle #2 or beyond -- if patient has tolerated the standard rate 20% of dose 30 min 80% of dose 60 min
rev. 9/2012 pump at this rate pump at this rate
dose in vol of IV bag size total vol of final conc mg mL mL / hr mg mL mL / hr
in in
mg drug added product mg/mL for 30 minutes
< 65 mg mixed to a custom volume to result in conc = 1 mg / mL
65 mg 6.5 mL 56mL NS 62.5 mL 1.04 mg/mL 13 in 12.5 25 mL/hr 52 in 50 50 mL/hr
75 mg 7.5 mL Hospira IV 63.5 mL 1.18 mg/mL 15 in 12.7 25.4 mL/hr 60 in 50.8 50.8 mL/hr
100 mg 10 mL bag 66 mL 1.51 mg/mL 20 In 13.2 26.4 mL/hr 80 In 52.8 52.8 mL/hr

125 mg 12.5 mL 112.5 mL 1.11 mg/mL 25 In 22.5 45 mL/hr 100 In 90 90 mL/hr

150 mg 15 mL 115 mL 1.30 mg/mL 30 In 23.1 46.2 mL/hr 120 In 92.4 92.4 mL/hr
175 mg 17.5 mL 117.5 mL 1.49 mg/mL 35 In 23.5 47 mL/hr 140 In 93.9 93.9 mL/hr
200 mg 20 mL Mixed in a 120 mL 1.67 mg/mL 40 In 23.9 47.8 mL/hr 160 In 95.8 95.8 mL/hr
225 mg 22.5 mL partial-fill 122.5 mL 1.84 mg/mL 45 In 24.5 49 mL/hr 180 In 97.8 97.8 mL/hr
250 mg 25 mL IV bag 125 mL 2 mg/mL 50 In 25 50 mL/hr 200 In 100 100 mL/hr
275 mg 27.5 mL containing 127.5 mL 2.16 mg/mL 55 In 25.5 51 mL/hr 220 In 101.9 101.9 mL/hr
300 mg 30 mL 100 mL NS 130 mL 60 In 26 52 mL/hr 240 In 104 104 mL/hr
2.31 mg/mL
325 mg 32.5 mL
in a 250mL 132.5 mL 65 In 26.5 53 mL/hr 260 In 106 106 mL/hr
2.45 mg/mL
container
350 mg 35 mL 135 mL 2.59 mg/mL 70 In 27 54 mL/hr 280 In 108 108 mL/hr
375 mg 37.5 mL 137.5 mL 2.73 mg/mL 75 In 27.5 55 mL/hr 300 In 110 110 mL/hr
400 mg 40 mL 140 mL 2.86 mg/mL 80 In 28 56 mL/hr 320 In 112 112 mL/hr
425 mg 42.5 mL 142.5 mL 2.98 mg/mL 85 In 28.5 57 mL/hr 340 In 114 114 mL/hr
450 mg 45 mL 145 mL 3.1 mg/mL 90 In 29 58 mL/hr 360 In 116 116 mL/hr
475 mg 47.5 mL 147.5 mL 3.22 mg/mL 95 In 29.5 59 mL/hr 380 In 118 118 mL/hr
500 mg 50 mL 150 mL 3.33 mg/mL 100 In 30 60 mL/hr 400 In 120 120 mL/hr
525 mg 52.5 mL 152.5 mL 3.44 mg/mL 105 In 30.5 61 mL/hr 420 In 122 122 mL/hr
550 mg 55 mL 155 mL 3.55 mg/mL 110 In 31 62 mL/hr 440 In 124 124 mL/hr
575 mg 57.5 mL 157.5 mL 3.65 mg/mL 115 In 31.5 63 mL/hr 460 In 126 126 mL/hr
600 mg 60 mL 160 mL 3.75 mg/mL 120 In 32 64 mL/hr 480 In 128 128 mL/hr
625 mg 62.5 mL 162.5 mL 3.85 mg/mL 125 In 32.5 65 mL/hr 500 In 130 130 mL/hr
650 mg 65 mL 165 mL 3.94 mg/mL 130 In 33 66 mL/hr 520 In 132 132 mL/hr

675 mg 67.5 mL 317.5 mL 2.12 mg/mL 135 In 63.9 127.4 mL/hr 540 In 254.8 254.8 mL/hr
700 mg 70 mL 320 mL 2.19 mg/mL 140 In 64.2 127.8 mL/hr 560 In 255.6 255.6 mL/hr
725 mg 72.5 mL Mixed in a 322.5 mL 2.25 mg/mL 145 in 64.4 128.9 mL/hr 580 in 257.6 257.6 mL/hr
750 mg 75 mL partial-fill 325 mL 2.31 mg/mL 150 In 64.9 129.8 mL/hr 600 In 259.6 259.6 mL/hr
775 mg 77.5 mL IV bag 327.5 mL 2.37 mg/mL 155 In 65.4 130.8 mL/hr 620 In 261.6 261.6 mL/hr
800 mg 80 mL containing 330 mL 2.42 mg/mL 160 In 66.1 132.2 mL/hr 640 In 264.4 264.4 mL/hr
825 mg 82.5 mL 250 mL NS 332.5 mL 2.48 mg/mL 165 In 66.5 133 mL/hr 660 In 266 266 mL/hr
850 mg 85 mL in a 500 mL 335 mL 170 In 66.9 133.8 mL/hr 680 In 267.6 267.6 mL/hr
2.54 mg/mL
875 mg 87.5 mL
container 337.5 mL 175 In 67.6 135.2 mL/hr 700 In 270.4 270.4 mL/hr
2.59 mg/mL
900 mg 90 mL 340 mL 2.65 mg/mL 180 In 67.9 135.8 mL/hr 720 In 271.6 271.6 mL/hr
925 mg 92.5 mL 342.5 mL 2.70 mg/mL 185 In 68.5 137 mL/hr 740 In 274 274 mL/hr
950 mg 95 mL 345 mL 2.75 mg/mL 190 In 69.1 138.2 mL/hr 760 In 276.4 276.4 mL/hr
975 mg 97.5 mL 347.5 mL 2.81 mg/mL 195 In 69.4 138.8 mL/hr 780 In 277.6 277.6 mL/hr
1000 mg 100 mL 350 mL 2.86 mg/mL 200 In 69.9 139.8 mL/hr 800 In 279.6 279.6 mL/hr