49

DAFTAR PUSTAKA

1. Suwitra K. Penyakit Ginjal Kronik. In: Sudoyo AW, Setiyohadi B, Alwi I, et

al., 3rd ed. Buku Ajar Ilmu Penyakit Dalam. Jakarta: InternaPublishing
2009:1035-1040.
2. Kdoqi, National Kidney F. KDOQI Clinical Practice Guidelines and Clinical
Practice Recommendations for Anemia in Chronic Kidney Disease.
American journal of kidney diseases : the official journal of the National
Kidney Foundation [Internet]. 2006 [cited 2013 sept 3]; 47(5 Suppl 3):S11-
145. Available from: Elsevier.
3. Crews DC, Plantinga LC, Miller ER, 3rd, et al. Prevalence of chronic kidney
disease in persons with undiagnosed or prehypertension in the United States.
Hypertension [Internet]. 2010 [cited 2013 sept 4]; 55(5):1102-1109.
Available from: HypertensionAHA.
4. Centers for Disease Control and Prevention (U.S.), National Center for
Health Statistics (U.S.), National Vital Statistics System (U.S.). National vital
statistics reports : from the Centers for Disease Control and Prevention,
National Center for Health Statistics, National Vital Statistics System. DHHS
publication no (PHS). Hyattsville, Md.: National Center for Health
Statistics:v [Internet]. 2013 [cited 2014 Jan 11]. Available from:
www.cdc.gov/nchs/products/nvsr.htm
5. Prodjosudjadi W, Suhardjono, Suwitra K, et al. Detection and prevention of
chronic kidney disease in Indonesia: initial community screening.
Nephrology [Internet]. 2009 [cited 2013 okt 4]; 14(7):669-674. Available
from: WileyOnlineLibrary.
6. Kusman Ibrahim ST, Kittikorn Nilmanat. Coping and Quality of Life among
Indonesians Undergoing Hemodialysis. Thai J Nurs Res [Internet]. 2009
[cited 2013 okt 4]; 13(2):117-109. Available from :
http://antispam.kmutt.ac.th/index.php/PRIJNR/article/view/6435
7. Suhardjono. The development of a continuous ambulatory peritoneal dialysis
program in Indonesia. Peritoneal dialysis international : journal of the
International Society for Peritoneal Dialysis [Internet]. 2008 [cited 2013 okt
4]; 28 Suppl 3:S59-62. Available from : Perit Dial Int.
8. Robinson BE. Epidemiology of chronic kidney disease and anemia. Journal
of the American Medical Directors Association [Internet]. 2006 [cited 2013
okt 4]; 7(9 Suppl):S3-6; quiz S17-21. Available from : Elsevier.
9. Denny SD, Kuchibhatla MN, Cohen HJ. Impact of anemia on mortality,
cognition, and function in community-dwelling elderly. The American
journal of medicine [Internet]. 2006 [cited 2013 okt 12];119(4):327-334.
Available from : Elsevier.
10. Thomas MC. Anemia in diabetes: marker or mediator of microvascular
disease? Nature clinical practice Nephrology [Internet]. 2007 [cited 2013 des
22];3(1):20-30. Available from : Elsevier.
 50

11. Ma JZ, Ebben J, Xia H, et al. Hematocrit level and associated mortality in
hemodialysis patients. Journal of the American Society of Nephrology :
JASN [Internet]. 1999 [cited 2013 des 22];10(3):610-619. Available from :
JASN.
12. Nurko S. Anemia in chronic kidney disease: causes, diagnosis, treatment.
Cleveland Clinic journal of medicine [Internet]. 2006 [cited 2013 des
22];73(3):289-297. Available from : PubMed
13. Madore F, Lowrie EG, Brugnara C, et al. Anemia in hemodialysis patients:
variables affecting this outcome predictor. Journal of the American Society
of Nephrology : JASN [Internet]. 1997 [cited 2013 des 22];8(12):1921-1929.
Available from : JASN.
14. Valliant A, Hofmann RM. Managing dialysis patients who develop anemia
caused by chronic kidney disease: focus on peginesatide. International
journal of nanomedicine [Internet]. 2013 [cited 2013 des 25];8:3297-3307.
Available from: PubMed Central.
15. Hsu CY, McCulloch CE, Curhan GC. Epidemiology of anemia associated
with chronic renal insufficiency among adults in the United States: results
from the Third National Health and Nutrition Examination Survey. Journal of
the American Society of Nephrology : JASN. 2002;13(2):504-510. Available
from: PubMed Central.
16. Afshar R, Sanavi S, Salimi J, et al. Hematological profile of chronic kidney
disease (CKD) patients in Iran, in pre-dialysis stages and after initiation of
hemodialysis. Saudi journal of kidney diseases and transplantation : an
official publication of the Saudi Center for Organ Transplantation, Saudi
Arabia [Internet]. 2010 [cited 2013 des 26];21(2):368-371. Available from:
MedKnow.
17. Prodjosudjadi W. Clinical Practice Guideline for the Evaluation and
Management of Chronic Kidney Disease. In Chasani S, Gasem MH, Arwanto
A, (Eds). Current Guidelines in Internal Medicine to Improve Clinical
Practice, Kumpulan Naskah Pertemuan Ilmiah Tahunan XVII PAPDI Cabang
Semarang. Semarang: Badan Penerbit Universitas Diponegoro 2013.
18. Imai E, Horio M, Watanabe T, et al. Prevalence of chronic kidney disease in
the Japanese general population. Clinical and experimental nephrology
[Internet]. 2009 [cited 2014 Jan 2];13(6):621-630. Available from :
SpringerLink.
19. CDC. National Chronic Kidney Disease Fact Sheet: General Information and
National Estimates on Chronic Kidney Disease in the United States. Atlanta:
US Department of Health and Human Services. Centers for Disease Control
and Prevention[Internet]. 2014 [cited 2014 Feb 4]. Available from :
http://www.cdc.gov/diabetes/pubs/factsheets/kidney.htm
20. Prodjosudjadi W, Suhardjono A. End-stage renal disease in Indonesia:
treatment development. Ethnicity & disease [Internet]. 2009 [cited 2014 Jan
2];19(1 Suppl 1):S1-33-36. Available from : PubMed.
21. Arsono S. Diabetes Melitus Sebagai Faktor Risiko Kejadian Gagal Ginjal
Terminal. Jurnal Epidemiologi. 2005.
 51

22. Sukandar E. Nefrologi Klinik. Bandung: Pusat Informasi Ilmiah UNPAD

2006.
23. Parsudi I, Siregar P, Roesli RMA. Hemodialisis. In Sudoyo AW, Setiyohadi
B, Alwi I, et al., (Eds). Buku Ajar Ilmu Penyakit Dalam. Jakarta:
InternaPublishing 2009:1050-1052.
24. Hamilton RW. Complications of Dialysis: Selected Topics. In Schrier RW,
(Ed). Atlas of Disease of The Kidney. Colorado 1998.
25. Zepeda-Orozco D, Quigley R. Dialysis disequilibrium syndrome. Pediatric
nephrology. 2012;27(12):2205-2211.
26. Bakta IM. Pendekatan Terhadap Pasien Anemia. In Sudoyo AW, Setiyohadi
B, Alwi I, et al., (Eds). Buku Ajar Ilmu Penyakit Dalam. Jakarta:
InternaPublishing 2009:1109-1115.
27. Turgeon ML. Clinical hematology : theory and procedures. Philadelphia:
Lippincott Williams & Wilkins 2004.
28. WHO. Haemoglobin concentrations for the diagnosis of anaemia and
assessment of severity. Geneva: World Health Organization [Internet]. 2011
[cited 2014 Jan 2]. Available from:
http://www.who.int/vmnis/indicators/haemoglobin/en/
29. Schrier RW. Diseases of the kidney & urinary tract. Philadelphia: Wolters
Kluwer Health/Lippincott Williams & Wilkins 2007.
30. Mehdi U, Toto RD. Anemia, diabetes, and chronic kidney disease. Diabetes
care [Internet]. 2009 [cited 2014 Jan 5];32(7):1320-1326. Available from :
PubMed Central.
31. McClellan W, Aronoff SL, Bolton WK, et al. The prevalence of anemia in
patients with chronic kidney disease. Current medical research and opinion
[Internet]. 2004 [cited 2014 Jan 7];20(9):1501-1510. Available from :
Informa Healthcare.
32. Suega K, Bakta M, Dharmayudha TG, et al. Profile of anemia in chronic
renal failure patients: comparison between predialyzed and dialyzed patients
at the Division of Nephrology, Department of Internal Medicine, Sanglah
Hospital, Denpasar, Bali, Indonesia. Acta medica Indonesiana [Internet].
2005 [cited 2014 Feb 7]; 37(4):190-194. Available from : ISoIM.
33. Astor BC, Muntner P, Levin A, et al. Association of kidney function with
anemia: the Third National Health and Nutrition Examination Survey (1988-
1994). Archives of internal medicine [Internet]. 2002 [cited 2014 Feb 7];
162(12):1401-1408. Available from : JAMA International.
34. Rosenblatt SG, Drake S, Fadem S, et al. Gastrointestinal blood loss in
patients with chronic renal failure. American journal of kidney diseases : the
official journal of the National Kidney Foundation [Internet]. 1982 [cited
2014 Mar 2]; 1(4):232-236. Available from : Elsevier.
35. Kuo CC, Kuo HW, Lee IM, et al. The risk of upper gastrointestinal bleeding
in patients treated with hemodialysis: a population-based cohort study. BMC
nephrology [Internet]. 2013 [cited 2014 Mar 2];14:15. Available from :
PubMed Central.
 52

36. Kaw D, Malhotra D. Platelet dysfunction and end-stage renal disease.

Seminars in dialysis [Internet]. 2006 [cited 2014 Feb 2];19(4):317-322.
Available from : WileyOnlineLibrary.
37. Boccardo P, Remuzzi G, Galbusera M. Platelet dysfunction in renal failure.
Seminars in thrombosis and hemostasis [Internet]. 2004 [cited 2014 Feb 2];
30(5):579-589. Available from : PubMed Central.
38. Fishbane S, Pollack S, Feldman HI, et al. Iron indices in chronic kidney
disease in the National Health and Nutritional Examination Survey 1988-
2004. Clinical journal of the American Society of Nephrology : CJASN
[Internet]. 2009 [cited 2014 Jan 13];4(1):57-61. Available from : PubMed
Central.
39. Bakta IM, Suega K, Dharmayuda TG. Anemia Defisiensi Besi. In Sudoyo
AW, Setiyohadi B, Alwi I, et al., (Eds). Buku Ajar Ilmu Penyakit Dalam.
Jakarta: InternaPublishing 2009:1127-1137.
40. Spinowitz BS, Kausz AT, Baptista J, et al. Ferumoxytol for treating iron
deficiency anemia in CKD. Journal of the American Society of Nephrology :
JASN [Internet]. 2008 [cited 2014 Jan 13]; 19(8):1599-1605. Available from
: PubMed Central.
41. Supandiman I, Fadjari H, Sukrisman L. Anemia Pada Penyakit Kronis. In
Sudoyo AW, Setiyohadi B, Alwi I, et al., (Eds). Buku Ajar Ilmu Penyakit
Dalam. Jakarta: InternaPublishing 2009:1138-1140.
42. Poggiali E, Migone De Amicis M, Motta I. Anemia of chronic disease: A
unique defect of iron recycling for many different chronic diseases. European
journal of internal medicine [Internet]. 2014 [cited 2014 Jan 14]; 25(1):12-17.
Available from: Elsevier.
43. Weiss G, Goodnough LT. Anemia of chronic disease. The New England
journal of medicine [Internet]. 2005 [cited 2014 Mar 4];352(10):1011-1023.
Available from: NEJM.
44. Rice L, Alfrey CP, Driscoll T, et al. Neocytolysis contributes to the anemia
of renal disease. American journal of kidney diseases : the official journal of
the National Kidney Foundation [Internet]. 1999 [cited 2013 Des 3];33(1):59-
62. Available from: Elsevier.
45. Means RT, Jr. Recent developments in the anemia of chronic disease. Current
hematology reports [Internet]. 2003 [cited 2013 Des 17];2(2):116-121.
Available from: PubMed.
46. Miller CB, Jones RJ, Piantadosi S, et al. Decreased erythropoietin response in
patients with the anemia of cancer. The New England journal of medicine
[Internet]. 1990 [cited 2014 Jan 22];322(24):1689-1692. Available from:
NEJM
47. Maciejewski JP, Selleri C, Sato T, et al. Nitric oxide suppression of human
hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma
and tumor necrosis factor-alpha. The Journal of clinical investigation
[Internet]. 1995 [cited 2013 Des 25]; 96(2):1085-1092. Available from:
PubMed Central.
 53

48. Armitage AE, Eddowes LA, Gileadi U, et al. Hepcidin regulation by innate
immune and infectious stimuli. Blood [Internet]. 2011 [cited 2013 Des
25];118(15):4129-4139. Available from: BloodJournal.
49. Nicolas G, Bennoun M, Porteu A, et al. Severe iron deficiency anemia in
transgenic mice expressing liver hepcidin. Proceedings of the National
Academy of Sciences of the United States of America [Internet]. 2002 [cited
2013 Des 29] ;99(7):4596-4601. Available from: PubMed Central.
50. Rinaldi I, Sudoyo AW. Anemia Hemolitik Non Imun. In Sudoyo AW,
Setiyohadi B, Alwi I, et al., (Eds). Buku Ajar Ilmu Penyakit Dalam. Jakarta:
InternaPublishing 2009:1157-1164.
51. Collins AJ, Foley RN, Chavers B, et al. 'United States Renal Data System
2011 Annual Data Report: Atlas of chronic kidney disease & end-stage renal
disease in the United States. American journal of kidney diseases : the
official journal of the National Kidney Foundation [Internet]. 2012 [cited
2014 Feb 25]; 59(1 Suppl 1):A7, e1-420. Available from: Elsevier.
52. Prakash S, O'Hare AM. Interaction of aging and chronic kidney disease.
Seminars in nephrology [Internet]. 2009 [cited 2014 Jan 24];29(5):497-503.
Available from: Elsevier.
53. Anderson S, Halter JB, Hazzard WR, et al. Prediction, progression, and
outcomes of chronic kidney disease in older adults. Journal of the American
Society of Nephrology : JASN [Internet]. 2009 [cited 2014 feb
2];20(6):1199-1209. Available from: Highwire.
54. Singh AK, Farag YM, Mittal BV, et al. Epidemiology and risk factors of
chronic kidney disease in India - results from the SEEK (Screening and Early
Evaluation of Kidney Disease) study. BMC nephrology [Internet]. 2013
[cited 2014 Mar 24];14:114. Available from: PubMed Central.
55. Akinsola A, Durosinmi MO, Akinola NO. The haematological profile of
Nigerians with chronic renal failure. African journal of medicine and medical
sciences [Internet]. 2000 [cited 2014 Jan 2];29(1):13-16. Available from:
PubMed.
56. Neugarten J, Acharya A, Silbiger SR. Effect of gender on the progression of
nondiabetic renal disease: a meta-analysis. Journal of the American Society
of Nephrology : JASN [Internet]. 2000 [cited 2014 Jan 2];11(2):319-329.
Available from: JASN.
57. Silbiger SR, Neugarten J. The impact of gender on the progression of chronic
renal disease. American journal of kidney diseases : the official journal of the
National Kidney Foundation [Internet]. 1995 [cited 2014 Apr 3];25(4):515-
533. Available from: Elsevier.
58. Prodjosudjadi W. Incidence, prevalence, treatment and cost of end-stage
renal disease in Indonesia. Ethnicity & disease [Internet]. 2006 [cited 2014
Jan 16]; 16(2 Suppl 2):S2-14-16. Available from: PubMed.
59. Bennett PN, Hany A. Barriers to kidney transplants in Indonesia: a literature
review. International nursing review [Internet]. 2009 [cited 2014 Mar 2];
56(1):41-49. Available from: WileyOnlineLibrary.
60. Tangri N, Stevens LA, Griffith J, et al. A predictive model for progression of
chronic kidney disease to kidney failure. JAMA : the journal of the American
 54

Medical Association [Internet]. 2011[cited 2014 Mar 2];305(15):1553-1559.

Available from: JAMA.
61. Annear NM, Banerjee D, Joseph J, et al. Prevalence of chronic kidney
disease stages 3-5 among acute medical admissions: another opportunity for
screening. QJM : monthly journal of the Association of Physicians [Internet].
2008 [cited 2014 Jun 5];101(2):91-97. Available from: Oxford Journal.
62. Post JB, Wilkes BM, Michelis MF. Iron deficiency in patients with chronic
kidney disease: potential role for intravenous iron therapy independent of
erythropoietin. International urology and nephrology [Internet]. 2006 [cited
2014 Jun 5];38(3-4):719-723. Available from: SpringerLink.
 55

Lampiran 1. Lembar Inform Consent

Persetujuan Setelah Penjelasan
(INFORMED CONSENT)

Berikut ini naskah yang akan dibacakan pada Responden / Ibu Responden
Penelitian :
Bapak/Ibu Yth :
Saya Dhanny Candra Adiatma, mahasiswa Fakultas Kedokteran Universitas
Diponegoro Semarang, Program Studi Kedokteran Umum. Saya bermaksud
melakukan penelitian mengenai Prevalensi dan Jenis Anemia Pada Pasien
Penyakit Ginjal Kronik Yang Menjalani Hemodialisis Reguler. Penelitian
ini dilakukan sebagai tahap akhir dalam penyelesaian studi di Fakultas
Kedokteran Universitas Diponogoro, Program Studi Kedokteran Umum.
Pada penelitian ini akan dilakukan pengumpulan data berupa data karateristik
demografi sampel berupa nama, umur, jenis kelamin, alamat, serta penyakit
yang mendasari. Kemudian akan dilakukan pengambilan sampel darah vena
sebanyak 5 cc untuk dilakukan pemeriksaan laboratorium yaitu kadar Hb,
complete blood count, hitung retikulosit, serum besi, TIBC dan billirubin
total. Terdapat ketidaknyamanan saat proses pengambilan darah vena.
Analisis laboratorik akan dilakukan di laboratorium RSUP Dr. Kariadi
Semarang. Seluruh biaya pada proses penelitian ditanggung oleh peneliti.
Peneliti akan menjaga kerahasiaan identitas dan informasi yang diberikan dan
hanya digunakan untuk kepentingan penelitian.
Terima kasih atas kerjasama Bapak/Ibu/Sdr.
Peneliti : Dhanny Candra Adiatma.
Nomor kontak peneliti : 085641221493

Setelah mendengar dan memahami penjelasan Penelitian, dengan ini saya

menyatakan

SETUJU / TIDAK SETUJU

Untuk ikut sebagai responden / sampel penelitian.

Semarang,
Saksi : Nama Terang :
Nama Terang : Alamat :
Alamat :
 56

Lampiran 2. Data Subjek

No Umur Sex Penyakit Hb MCV MCH MCHC Tromb Rtc Leu TIBC SI Bill total
1 55 W Diabetes Mellitus 8.95 91.4 30.9 33.8 245 2.76 5.98 245 37 0.18
2 76 P Hipertensi 9.85 90.5 30.7 33.9 160 1.41 5.37 287 44 0.39
3 64 P Diabetes Mellitus 10.5 86.6 29.3 33.8 252 3.72 5.57 234 37 0.23
4 48 P Diabetes Mellitus 8.5 75.9 27 33.2 248 3.72 7.62 249 38 0.23
5 54 P Diabetes Mellitus 10.1 84.4 27.9 33 143 3.79 8.99 346 56 0.78
6 44 W Hipertensi 10.3 90.4 29.6 32.8 251 1.56 4.85 222 114 0.31
7 50 P Diabetes Mellitus 9.7 81.9 27.5 33.6 144 1.35 6.47 269 34 0.51
8 43 P Obstruksi Ginjal 8.49 84.7 29.6 34.9 428 2.73 6.46 341 162 0.25
9 52 W Hipertensi 10.2 77.6 26.7 33.1 271.2 2 6.6 273 134 0.39
10 62 W Diabetes Mellitus 11.4 84.9 28 33 309.3 3.1 9.8 326 57 1.1
11 69 W Obstruksi Ginjal 8.7 85.8 29.1 34 406 0.4 3.9 175 8 0.33
12 52 P Obstruksi Ginjal 8.1 73.3 24.4 29 302 4.3 8.1 370 50 0.33
13 71 P Diabetes Mellitus 9.1 88 29 33.7 161.8 1.1 4.4 285 97 0.24
14 57 P Diabetes Mellitus 10.2 67.1 22.5 29.5 222.5 1.2 5.3 361 52 0.28
15 52 P Diabetes Mellitus 8.2 74.4 24.6 30 225.7 0.5 5.9 346 16 1.39
16 61 P Hipertensi 8.8 83 27.6 33.3 134 0.9 4.5 263 152 0.28
17 74 P Hipertensi 9.9 83.7 28.6 34.1 170 1.4 5.7 244 51 0.43
18 49 W Diabetes Mellitus 9.2 82.4 26.9 32 181.1 2.6 4.6 285 67 0.44
19 65 P Diabetes Mellitus 8.7 82.5 28.3 34.2 76 0.4 2.2 338 89 1.18
20 66 P Diabetes Mellitus 10.3 92.6 29.3 31.6 174.4 - 8.6 215 42 0.76
21 25 P Hipertensi 8.9 84.2 29.1 34.6 198 2.71 7.4 236 182 0.37
22 53 P Hipertensi 8.2 89 28 31.3 427 1.7 7.4 210 55 0.87
23 25 W Hipertensi 9.6 78 26 33 218 0.4 5.9 223 53 0.35
24 54 W Hipertensi 10.6 85 28 33.9 216.7 0.9 7 288 68 0.78
25 77 W Hipertensi 8.7 89.2 30.1 33.7 254.4 1.3 9.7 172 44 0.51
26 36 P Obstruksi Ginjal 8.2 83.2 28.8 34.5 209.5 1.33 6.1 235 50 -
27 52 W Diabetes Mellitus 8.1 87 29.3 33.7 197.8 1.73 7.9 219 52 0.43
28 57 P Diabetes Mellitus 8.1 82 26.5 32.3 155 3 5.3 209 49 0.23
29 76 P Diabetes Mellitus 9.6 89.5 30.4 34 211.4 0.9 5.5 305 68 0.26
30 51 P Hipertensi 8.8 82 27.7 33.7 139 1.24 5.5 245 49 0.33
31 55 P Hipertensi 13.4 86.6 29.3 33.7 155.9 1.23 7.5 325 74 0.74
32 32 W Hipertensi 12.1 82.6 27.6 33.4 230 1.5 7.8 355 24 0.33
33 52 P Hipertensi 13.1 85 29 34 251 - 6.6 - - -
34 55 W Diabetes Mellitus 12.5 82.6 27.7 33.6 208 - 6.7 298 61 -
35 54 P Hipertensi 13 87 29 33.4 299.3 - 4.7 - - -
 57

Lampiran 3. Ethical Clearance