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Pigs, the viruses ca n re-assort (i.e. Swap genes) leading to influenza (Flu) pandemics are caused by new development of new n ovel strain. There are four main influe nza type a virus subtypes both in terms of recurrence and magnitude.
Pigs, the viruses ca n re-assort (i.e. Swap genes) leading to influenza (Flu) pandemics are caused by new development of new n ovel strain. There are four main influe nza type a virus subtypes both in terms of recurrence and magnitude.
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Pigs, the viruses ca n re-assort (i.e. Swap genes) leading to influenza (Flu) pandemics are caused by new development of new n ovel strain. There are four main influe nza type a virus subtypes both in terms of recurrence and magnitude.
Copyright:
Attribution Non-Commercial (BY-NC)
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Scarica in formato TXT, PDF, TXT o leggi online su Scribd
Monthly Newsletter of National Institute of Communicable Di
seases, Directorate General of Health Services, Government of In dia March- April 2009 Vol.12 : No.8 Special Issue: Human Swine Influenza: a pandemic threat pigs, the viruses ca n re-assort (i.e. swap genes) INTRODUCTION and new viruses , a mix of swine, human and/or avian influenza viru ses - can emerge leading to Influenza (Flu) pandemics are caused by new development of new n ovel strain for which influenza viruses that have recently adapted to human beings do not have no immunity. There humans and resemble major natural disasters are four main influe nza type A virus subtypes both in terms of recurrence and magnitude. that have been isola ted in pigs: H1N1, H1N2, The influenza virus, known to be circulating as H3N1 and H3N2. Howev er, most of the recently a pathogen in the human population since at least the 16th century is notable for its unique isolated influenza v iruses from pigs have been H1N1 viruses. ability to cause recurrent epidemics and global pandemics. Genetic re-assortments in the influenza virus cause fast and unpredictable Swine flu virus spre ads mostly through close antigenic changes in important immune targets contact among pigs a nd possibly from leading to recurrent epidemics of febrile contaminated objects moving between infected respiratory disease every 1 to 3 years, and uninfected pigs. Symptoms of swine flu in consistently necessitated the development of pigs can include sud den onset of fever, new vaccines. Each century has seen some depression, coughing (barking), discharge pandemics rapidly progressing to all parts of from the nose or eye s, sneezing, breathing the world due to emergence of a novel virus to difficulties, eye re dness or inflammation, and which the overall population holds no going off feed. immunity. SWINE FLU IN HUMANS SWINE FLU IN PIGS Swine flu viruses do not normally infect humans. Swine Influenza (swine flu) is a respiratory However, sporadic hu man infections with swine disease of pigs caused by type A influenza flu have occurred. M ost commonly, these cases virus that regularly causes outbreaks of occur in persons hav ing direct exposure to pigs. influenza in pigs. Swine flu viruses cause high In addition, there h ave been sporadic cases of levels of illness and low death rates in pigs. one person spreading swine flu to others. Swine influenza viruses usually circulate Occasional human swi ne influenza virus among swine throughout the year, but most infection occurs eve ry one to two years in the outbreaks occur during the late fall and winter U.S., but from Decem ber 2005 through February months similar to outbreaks in humans. The 2009, 12 cases of hu man infection with swine classical swine flu virus (an influenza type A influenza have been reported. H1N1 virus) was first isolated from a pig in 1930. H3N2 influenza viruses began SWINE FLU OUTBREAK circulating among pigs from 1998. The H3N2 viruses initially were introduced into the pig Recently, human case s of swine influenza A population from humans. (H1N1) virus infecti on have been recently reported in several countries. This is a novel Like all influenza viruses, swine flu viruses influenza A virus th at has not been identified in change constantly. Pigs can be infected by people before, and human-to-human avian influenza, human influenza viruses as transmission of the virus appears to be well as swine influenza viruses and hence the ongoing and thus rep resents a real pandemic pigs are known to be a mixing vessel. When threat. WHO has upgr aded the phasing of influenza viruses from different species infect pandemic influenza f rom Phase -3 to Phase - 5 1 WHO PHASES OF PANDEMIC ALERT Influenza A HA and NA Subtypes (Source: WHO) N1 H1 N2 H2 N3 H3 N4 H4 N5 H5 N6 H6 H7 N7 H8 N8 H9 N9 H10 H11 H12 H13 H14 H15, H16 The above diagram shows various subtypes of Phase 1 No animal influe nza virus circulating Influenza, A virus which infects humans, swine, among animals ha s been reported to birds, poultry and horses and other animals, but cause infections in humans. wild birds are the natural hosts for these viruses. Phase 2 An animal influe nza virus circulating Influenza type A viruses are divided into subtypes among domesticat ed or wild animals and named on the basis of two proteins on the is known to have caused infection in surface of the virus: hemagglutinin (HA) and humans, and is t herefore considered neuraminidase (NA. There are 16 known HA a specific poten tial pandemic threat. subtypes and 9 known NA subtypes. Many different Phase 3 An animal or hum an-animal influenza combinations of HA and NA proteins are possible. . reassortant viru s has caused sporadic For example, an “H1N1” virus has an HA 1 protein cases or small c lusters of disease in and an NA 1 protein Only some influenza A people, but has not resulted in human- subtypes (i.e., H1N1, H1N2, and H3N2) are to-human transmi ssion sufficient to currently in general circulation among people. sustain communit y-level outbreaks. Other subtypes are found most commonly in other Phase 4 Human-to-human t ransmission(H2H) animal species. of an animal or human-animal influenza reasso rtant virus able to Current Situation: The current situation sustain “communi ty-level outbreaks regarding the outbreak of swine influenza has been verifie d. A(H1N1) is evolving rapidly. As on 29 April Phase 5 The same identif ied virus has caused 2009, nine countries have officially reported sustained commun ity level outbreaks in two or more c ountries in one WHO 148 confirmed cases of swine influenza region A/H1N1 infection. Of these, United States has Phase 6 The pande mic phase, is reported 91 laboratory confirmed human characterized by community level cases, including one death. Mexico has outbreaks in at least one other country reported 26 confirmed human cases including in a different W HO region in addition to seven deaths. the criteria def ined in Phase 5. Post Peak Levels of pandem ic influenza in most The following countries have reported Period countries with a dequate surveillance laboratory confirmed cases with no deaths - have dropped bel ow peak levels Austria (1), Canada (13), Germany (3), Israel Possible Level of pandemi c influenza activity in new wave most countr ies with adequate (2), New Zealand (3), Spain (4) and the United surveillance ris ing again Kingdom (5). All these cases have history of Post Levels of Influe nza activity have travel to Mexico. Pandemic returned to leve ls seen for seasonal Period influenza in mos t countries with Unlike the experience in Mexico, the United adequate surveil lance. States is currently reporting infection by the identical virus strain or less severe clinical The current WHO phase of pan demic alert is 5. spectrum of disease. Mexican health officials WHO has declared the outbrea k as PUBLIC have reported several hundred suspect cases, HEALTH EMERGENCY OF INTERNAT IONAL including several deaths associated with swine CONCERN (PHEIC) influenza A (H1N1) virus infection. In Mexico, many patients have experienced rapidly progressive pneumonia, respiratory failure and (Source: WHO: Pa ndemic influenza acute respiratory distress syndrome (ARDS) preparedness and response) requiring mechanical ventilation. 2 A probable case of swine influenza A (H1N1) virus INFLUENZA SURVEILLANCE infection is defined as a person with an acute febrile respiratory illn ess who: Surveillance is the foundation of all efforts to understand and control influenza. The monitoring of is positive for influe nza A, but unsubtypable for influenza disease patterns is essential for H1 and H3 by influenz a RT-PCR or reagents identification of high risk groups, planning of used to detect season al influenza virus infection, prevention and response activities for complications or and for estimating the burden of disease in terms of is positive for influe nza A by an influenza rapid health and economic impact. test or an influenza immunofluorescence assay (IFA) plus meets crit eria for a suspected case, or It is important to use standardized case definitions individual with a clin ically compatible illness who that enable comparisons between different areas died of an unexplaine d acute respiratory illness within a country and also between countries. There who is considered to be epidemiologically linked are two case definitions used by the influenza to a probable or conf irmed case. surveillance system: A confirmed case of swin e influenza A (H1N1) virus 1. Influenza-like illness (ILI) is defined (according infection is defined as a person with an acute febrile to WHO criteria) as: respiratory illness with laboratory confirmed swine • Sudden onset of a fever over 38°C, AND influenza A (H1N1) virus infection at WHO approved • Cough or sore throat, AND laboratories by one or m ore of the following tests: • An absence of other diagnoses. 2. Severe Acute Respiratory Infections (SARI):. Real Time PCR Viral culture For persons ≥ 5 years the definition for SARI is Four-fold rise in swin e influenza A (H1N1) virus adapted from the WHO protocol on rapid specific neutralizing antibodies. response: • Sudden onset of fever over 38°C, AND OTHER DEFINITIONS • Cough or sore throat, AND • Shortness of breath or difficulty in breathing, AND Close contact is defined within 6 feet of an ill • Requiring hospital admission person who is a confirme d, probable or suspected case of swine influenza A (H1N1) virus infection For children <5 years old: definition is adapted during the infectious pe riod. from the program for Integrated Management of Childhood Illness (IMCI): Any child <5 years old clinically suspected of Acute respiratory illnes s is defined as illness of having Pneumonia or Severe/very Severe recent onset with least two of the following: Pneumonia and requiring hospital admission. rhinorrhea or nasal cong estion, sore throat, cough (with or without fever). 3. Confirmed case of influenza is defined as any case with laboratory test results positive for High-risk group for comp lications of influenza is influenza virus. defined as a person such as: resident of institu tions for elderly people and CASE DEFINITION OF SWINE FLU IN the disabled; HUMANS people with certain chronic health conditions (chronic heart or l ung disease, metabolic or renal disease or im munodeficiencies); A suspected case of swine influenza A (H1N1) elderly people and very young children. virus infection is defined as a person with acute febrile respiratory illness (fever ≥ 380 C) with onset. Infectious period: The i nfectious period for a confirmed case of swine influenza A (H1N1) virus within 7 days of close contact with a person who infection is defined as 1 day prior to the onset of is a confirmed case of swine influenza A (H1N1) illness to 7 days after onset. virus infection, or within 7 days of travel to areas where there are TRANSMISSION one or more confirmed swine influenza A(H1N1) cases, or resides in a community where there are one or Influenza viruses can be directly transmitted from more confirmed swine influenza cases. pigs to people and fr om people to pigs. Human infection with f lu viruses from pigs are most likely to occur when people are in close 3 proximity to infected pigs, such as in pig barns labeled clearly and in clude patient’s and livestock exhibits housing pigs at fairs. complete information a nd should be sent to Human-to-human transmission of swine flu can NIV, Pune or NICD, Del hi within 24 hours also occur. This is thought to occur in the same for further investigat ions. way as seasonal flu which is mainly person-to- Laboratory biosafety m easures should person transmission through coughing or be followed for collec tion, storage, sneezing by people infected with the influenza packaging and shipping of influenza virus. samples. Disease spreads very quickly among the Available Laboratory t ests: population especially in crowded places. Rapid Antigen Tests: not as sensitive as Cold and dry weather enables the virus to survive longer outside the body than in other conditions other available tes ts. and, as a consequence, seasonal epidemics in RT-PCR temperate areas appear in winter. Virus isolation People may become infected by Virus Genome Sequenc ing touching/handling something contaminated with Four-fold rise in sw ine influenza A flu viruses on it and then touching their mouth or (H1N1) virus specific neutralizing nose. antibodies. Swine influenza viruses are not transmitted by food. Eating properly handled and cooked pork (at an It is important to note that samples from internal temperature of ≥160°F) and pork all cases, once the Pand emic starts, are products is safe. not required to be teste d. SYMPTOMS Important Contact Number s: Outbreak Monitoring Cell (Control Room, The symptoms of swine flu in people are NICD): 011-23921401 expected to be similar to the symptoms of EMR Control room (Minist ry of Health and regular human seasonal influenza like fever, family Welfare: 011- 230 61469 lethargy, lack of appetite and cough. Some Important Websites: people have also reported runny nose, sore www.mohfw.nic.in; www.ni cd.nic.in throat, nausea, vomiting and diarrhoea. PREVENTIVE MEASURES DIAGNOSIS OF SWINE FLU There is currently no vacc ine available For diagnosis of swine influenza A infection, against human swine influe nza. One has respiratory specimen would generally need to to follow proper hand hygi ene and be collected within the first 4 to 5 days of respiratory etiquettes. illness (when an infected person is most likely to be shedding virus). However, some Do’s and Don’ts: persons, especially children, may shed virus for 10 days or longer. Avoid close contact wi th people who are having respiratory il lness. Sample Collection & Laboratory Diagnosis Sick persons should ke ep distance from others. If possible, stay at h ome, away from work, Sample Collection and handling is same school, and public pl aces when you are as for human avian flu or seasonal sick. influenza like illness (Refer CD Alert on AI). Cover your mouth and n ose with a tissue or Sample Collection: should be done by the handkerchief when cou ghing or sneezing. treating doctor who is managing the case. If you have no tissue or handkerchief you Preferred respiratory samples : should not clean the nose with the hands nasopharyngeal swab and throat swab but with the cuff of your shirt or clothes. Storage of Samples: all samples should Washing your hands oft en with soap or be kept at 2-80C until they can be placed at alcohol based hand wa sh will help protect -700C. from germs. Get plenty of sleep, b e physically active, Transportation of Samples: Clinical manage your stress, d rink plenty of fluids, samples should be transported on dry ice and eat nutritious fo od. in triple packaging. All samples should be 4 Schools and childcare facilities in Persons who develop influenza-like-illness o unaffected areas shou ld begin to prepare (ILI) (fever with either cough or sore throat) for the possibility o f school or childcare should be strongly encouraged to self- facility closure. isolate in their home for 7 days after the onset of illness or at least 24 hours after Social Distancing Interven tions: symptoms have resolved, whichever is o Large gatherings linked to settings or longer. institutions with laboratory-confirmed cases should be cance lled, for example a Persons who experience ILI and wish to school event linked t o a school with cases; seek medical care should contact their other large gathering s in the community health care providers to report illness (by may not need to be ca ncelled at this time. telephone or other remote means) before o Additional social distan cing measures are seeking care at a clinic, physician’s office, currently not recomme nded. or hospital. o Persons with underlying medical Persons who have difficulty breathing or conditions who are at high risk for shortness of breath should seek immediate complications of infl uenza may wish to medical attention and report to the nearby consider avoiding lar ge gatherings. hospital. If ill persons must go into the community SWINE INFLUENZA A (H1N1) VIR US: (e.g., to seek medical care) they should wear a face mask to reduce the risk of BIOSAFETY GUI DELINES FOR spreading the virus in the community. LABORATORY WORKERS If a face mask is unavailable, ill persons needing to go into the community should Laboratory workers who may b e processing or use a handkerchief or tissues to cover any performing diagnostic testin g on clinical specimens coughing and sneezing. from patients with suspected swine influenza A Persons in home isolation and their (H1N1) virus infection, or p erforming viral isolation. household members should be given infection control instructions like frequent Diagnostic laboratory work o n clinical samples from hand washing with soap and water; use of patients who are suspected c ases of swine alcohol-based hand gels (containing at least influenza A (H1N1) virus inf ection should be 60%alcohol). conducted in a BSL2 laborato ry. All sample When the ill person is within 6 feet of others manipulations should be done inside a biosafety at home, the ill person should wear a face cabinet. mask, if available or handkerchief or tissues. Viral isolation on clinical specimens from patients Household contacts who are well should: who are suspected cases of s wine influenza A remain home at the earliest sign of illness; o (H1N1) virus infection shoul d be performed in a minimize contact in the community to the o BSL2 laboratory with BSL3 pr actices (enhanced extent possible; BSL2 conditions). designate a single household family o member as the ill person’s caregiver to minimize interactions with asymptomatic Additional precautions inclu de: persons. Precautions for School children: Recommended Personal Pr otective Equipment Schools with a confirmed or a suspected o (based on site specific risk assessment ) case should be considered for closure. Respiratory protection – fit-tested N95 All school or childcare related gatherings o respirator or higher le vel of protection. should be cancelled and encourage Shoe covers parents and students to avoid Closed-front gown congregating outside of the school. Double gloves Schools and childcare facilities should bar o Eye protection (goggles or face shields) students for a time period to be evaluated Appropriate disinfectan ts on an ongoing basis depending upon o 70% Ethanol epidemiological findings. o 5% Lysol Schools and childcare facilities should o o 10% Bleach consult with their local or state health departments for guidance on reopening. If All personnel should self mo nitor for fever and other no additional confirmed or suspected symptoms of Swine influenza. Any illness should be cases are identified among students (or reported to the supervisor i mmediately. school-based personnel) for a period of 7 days, schools may consider reopening. 5 Oseltamivir is the dru g of choice. For personnel who had unprotected exposure or a Prophylaxis should be provided till 10 days after known breach in personal protective equipment to clinical material or live virus from a confirmed case last exposure (maximu m period of 6 weeks) By Weight: of swine influenza A (H1N1), antiviral chemoprophylaxis with oseltamivir for 7 days after For weight <1 5kg: 30 mg OD 15-23kg: 45 mg OD exposure can be considered. 24-<40kg: 60 mg OD ≥40kg: 75 mg OD Waste disposal For infants: < 3 months: not recommended unless All waste disposal procedures should be followed situation jud ged critical due to limited data as outlined in the respective facility standard on use in thi s age group laboratory operating procedures. 3-5 months: 20 mg OD 6-11 months : 25 mg OD ANTIVIRAL TREATMENT Close Contacts of susp ected, probable and Oseltamivir is the recommended drug both for confirmed cases shoul d be advised to remain at prophylaxis and treatment. home (voluntary home quarantine) for at least 7 days after the last c ontact with the case. Supportive therapy includes: Monitoring of fever s hould be done for at least 7 - IV Fluids. days. Prompt testing and hospitalization must be - Parentral nutrition. done when symptoms ar e reported. - Oxygen therapy/ ventilatory support. - Antibiotics for secondary infection. All suspected cases, clu sters of ILI/SARI cases need to be - Vasopressors for shock. notified to the State He alth Authorities and the Ministry of Health - Paracetamol or ibuprofen is prescribed for fever, & Family Welfare, Govt. of India (Director, EMR and Director, NICD) myalgia and headache. Patient is advised to drink plenty of fluids. Smokers should avoid FREQUENTLY ASKED QUESTIO NS smoking. For sore throat, short course of topical decongestants, saline nasal drops, throat What is swine flu? lozenges and steam inhalation may be beneficial. Swine Influenza (swine f lu) is a respiratory disease - Salicylate / aspirin is strictly contra-indicated in of pigs caused by type A influenza viruses that any influenza patient due to its potential to causes regular outbreaks in pigs. People do not cause Reye’s syndrome. normally get swine flu, but human infections can and do happen. Swine flu viruses have been The suspected cases would be constantly reported to spread from person-to-person, but in monitored for clinical / radiological evidence of the past, this transmiss ion was limited and not lower respiratory tract infection and for hypoxia sustained beyond three p eople. (respiratory rate, oxygen saturation, level of Are there human infectio ns with swine flu in consciousness). India.? In late March and early April 2009, cases of human Adult patients should be discharged 7 days after infection with swine inf luenza A (H1N1) viruses were symptoms have subsided. first reported in Southe rn California and near San Children should be discharged 14 days after Antonio, Texas. Other U. S. states have reported symptoms have subsided. cases of swine flu infec tion in humans and cases have been reported inter nationally as well. Central & The family of patients discharged earlier should be State Health Authorities are monitoring the situation educated on personal hygiene and infection control in India. So far, no cas e has been reported. measures at home; children should not attend Is this swine flu virus contagious? school during this period. CDC has determined that this swine influenza A (H1N1) virus is contagio us and is spreading from ANTIVIRAL CHEMOPROPHYLAXIS human to human. However, at this time, it is not known how easily the vir us spreads between people Prophylaxis is given to: and between countries. What are the signs and s ymptoms of swine flu in All close contacts of suspected, probable and people? confirmed cases. Close contacts include The symptoms of swine fl u in people are similar to household /social contacts, workplace or school the symptoms of regular human flu and include contacts, fellow travelers etc. fever, cough, sore throa t, body aches, headache, All health care personnel coming in contact with chills and fatigue. Some people have reported suspected, probable or confirmed cases 6 diarrhea and vomiting associated with swine flu. In What can I do to protec t myself from getting the past, severe illness (pneumonia and respiratory sick? failure) and deaths have been reported with swine flu Currently available sea sonal influenza vaccine does infection in people. Like seasonal flu, swine flu may not protect against swi ne flu. There are everyday cause a worsening of underlying chronic medical actions that can help p revent the spread of germs conditions. that cause respiratory illnesses like influenza. Take these everyday steps to protect your health: How does swine flu spread? Spread of swine influenza A (H1N1) virus is thought Cover your nose and m outh with a tissue when to be happening in the same way as that of seasonal you cough or sneeze. Throw the tissue in the trash flu. Flu viruses are spread mainly from person to after you use it. person through coughing or sneezing of people with Wash your hands often with soap and water, influenza. Sometimes people may become infected especially after you cough or sneeze. Alcohol- by touching something with flu viruses on it and then based hand cleaners are also effective. touching their mouth or nose. Avoid touching your e yes, nose or mouth. Germs spread this way. How can someone with the flu infect someone Try to avoid close co ntact with people having else? respiratory illness. Infected people may be able to infect others If one gets sick with influenza, one must stay at beginning 1 day before symptoms develop and up to home, away from work or school and limit contact 7 or more days after becoming sick. with others to keep from infecting them. However, What should I do to keep from getting the flu? if one is having any respiratory distress, one First and most important: wash your hands should report to a n earby hospital. frequently. Try to stay in good general health. Get What should I do if I g et sick? plenty of sleep, be physically active, manage your stress, drink plenty of fluids, and eat nutritious food. If you live in areas wh ere swine influenza cases Avoid touching surfaces that may be contaminated have been identified an d become ill with influenza- with the flu virus. Avoid close contact with people like symptoms e.g. feve r, body aches, runny nose, having respiratory illness. sore throat, nausea, or vomiting or diarrhea, you may contact their healt h care provider, particularly if Are there medicines to treat swine flu? you are worried about y our symptoms. Your health Yes. The use of oseltamivir for the treatment and/or care provider will dete rmine whether influenza prevention of infection with these swine influenza testing or treatment is needed. viruses is recommended. Antiviral drugs fight against the flu by keeping flu viruses from reproducing in If you are sick, you sh ould stay home and avoid your body. If you get sick, antiviral drugs can make contact with other peop le as much as possible to your illness milder and make you feel better faster. keep from spreading you r illness to others. If you They may also prevent serious flu complications. For become ill and experien ce any of the following treatment, antiviral drugs work best if started soon warning signs, seek eme rgency medical care. after getting sick (within 2 days of symptoms). They In children emergency w arning signs that need are currently available with hospitals and are to be urgent medical attentio n include: administered under supervision of clinicians. Fast breathing or trouble breathing How long can an infected person spread swine Bluish skin color flu to others? Not drinking enou gh fluids/eating food People with swine influenza virus infection should be Not waking up or not interacting considered potentially contagious as long as they are Being so irritabl e that the child does not symptomatic and possibly for up to 7 days following want to be held onset of illness. Children, especially younger children, might potentially be contagious for longer periods. Flu-like symptoms improve but then return with fever and wo rse cough What surfaces are most likely to be sources of Fever with a rash contamination? In adults, emergency wa rning signs that need Germs can be spread when a person touches urgent medical attentio n include: something that is contaminated with germs and then touches his or her eyes, nose, or mouth. Difficulty breathi ng or shortness of breath Droplets from a cough or sneeze of an infected Pain or pressure i n the chest or abdomen person move through the air. Sudden dizziness Confusion How long can viruses live outside the body? We know that some viruses and bacteria can live 2 Severe or persiste nt vomiting hours or longer on surfaces like cafeteria tables, Can I get swine influen za from eating or doorknobs, and desks. Frequent hand washing will preparing pork? help you reduce the chance of getting contamination No. swine influenza vir uses are not spread by food. from these common surfaces. Eating properly handled and cooked pork products is safe. 7 ...about CD Alert CDAlert is a monthly newsletter of the National Institute of Communicable Diseas es (NICD) , Directorate General of Health Services, to disseminate information on various aspects of communicable diseases to medical fraternity and health administrators. The newsletter may be reproduced, in part or whole, for educatio nal purposes. Chief Editor: Dr. R. K. Srivastava Editorial Board: Dr. Shiv Lal, Dr. R. L. Ichhpujani, Dr. Shashi Khare, Dr. A. K. Harit Guest Editor (Authors): Dr Archana Aravindan, Dr. Avdhesh Kumar, Dr Arti Bahl, Dr Shashi Khare Publisher: Director, National Institute of Communicable Diseases, 22 Shamnath Marg, Delhi 110 054 Tel: 011-23971272, 23971060 Fax : 011-23922677 E-mail: dirnicd@bol.net.in and dirnicd@gmail.com Websi te: www.nicd.nic.in Acknowledgement: Financial assistance by WHO/USAID is duly acknowledged . 8