NAME : BESSE NUR RAHMI WARSITA

NIM : I11116307

Genetic polymorphism

Genetic polymorphism is a genetic variation in the population structure. To determine

whether a population can safely be in the know with the disclosure of genetic
polymorphisms. Genetic polymorphisms occur because of changes in the arrangement of
nucleotides in a gene. Changes in the composition is influenced by several factors, among
others, mating, mutation and natural selection as well as the results of the process
buatan.Sebagaievolution, Polymorphism can be inherited and modified by natural selection,In
polymorphism, The genes of an individual allows a variety of forms, and the environment
determine which form will be shown.
In the genetic polymorphism of variation can also cause different activity and capacity
of an enzyme in performing its function. The existence of differences in genetic expression
between each individual will be able to provide different responses to the fate of drugs in the
body. This we can review mainly from the aspects of body metabolism. The metabolic
process occurs by enzyme aids. Enzyme is a protein whose existence is the result of genetic
expression (protein synthesis). The capacity of the enzymes produced by each individual is
different. This is one of the things that spur the difference in the body's response to the use of
the same drug. For example isoniazid drug used as antitubercolosis. Studies on the speed of
acetylation of isoniazid (N-acetylation) show that there is a difference in the ability of
acetylation of each individual based on genetic factors, has 2 types, ie fast acetylator type and
slow acetylator. The difference is due to the genetic variation of the encoding gene
expression of the enzyme N-acetylastransferase.
Genetic diversity is the basis of crossbreeding for livestock because this information
can be used as a starting point to increase the quantity and quality of livestock through
artificial selection. Genetic variation is an act of increasing genetic diversity among
populations and allows for new traits to be more or less visible. Variations of the genetic top
two include:

1. Variations that are quantitative, ie variations that can be seen in the form of a
mathematical sequence (continuum) and determined by many genes (polygeni). For
example: height, weight, and amount.

2. Variations that are qualitative, ie variations that are discontinuous (not sequenced
according to mathematical series) and determined by one gene (monogeni). For
example: skin color and blood type
Referens

Buis, R. C, et al. Preserving genetic resources 1994. variance in commercial and non-
commercial Populations. Netherlands Journal of Agricultural Science. No. 42: 29-36.

Murray, RK, et al. 2014. Biochemistry Harper (Harper's illustrated biochemistry). Jakarta:
EGC. edition 29

Wadelius M, Sorlin K, Wallerman O, Karlsson J, Yue QY, Magnusson PK, Wadelius C,

Melhus H. Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and
other factors. Pharmacogenomics J. 2004; 4 (1): 40-8.

Wandia, IN, Son IGAA ,, Soma IG. Population Genetic Polymorphisms 2009. Long-tailed
monkeys in tourist locations, Bali.Fakultas Veterinary Medicine. Fundamental Reports
DIPA funds Udayana University in the 2009 fiscal year.

Simple. Polymorphism (Biology), (Online), (id.m.wikipedia.org, accessed August 24, 2017).