Quiz #2

Midterm Coverage

Instruction: Write your answers on 1 whole sheet of yellow paper. You may use the
questionnaire as your scratch. NO ERASURES.

1. Define: (2 points each)

a. Absorption
b. Distribution
c. Metabolism
d. Excretion
e. Bioavailability
f. Bioequivalent
g. Plasma protein binding
h. First-pass effect
i. Enterohepatic recirculation
2. Give 2 factors affecting drug permeation. Describe how it affects absorption of
the drug (4 points)
3. Phase I reaction is also known as ______________.
4. Phase II reaction is also known as ______________.
5. Metabolism is also called _____________.
6. Describe and explain what happens if: (3 points each)
a. Infants were given Chloramphenicol
b. Sulfonamides were prescribed to Eskimos
c. Morphine was taken with Ketoconazole
d. A patient with uncontrolled calcium release was given neuromuscular
blocker
e. A patient taking oral contraceptive pills has chronic alcoholism
7. Give at least 6 reaction types for Phase I Metabolism. Cite at least one example
of drugs each. (12 points)
8. It is the major excretory organ of the body.
9. Give 4 other modes of excretion of drugs.
 Quiz #2
Midterm Coverage

Instruction: Write your answers on 1 whole sheet of yellow paper. You may use the
questionnaire as your scratch. NO ERASURES.

1. Define: (2 points each)

a. Absorption
b. Distribution
c. Metabolism
d. Excretion
e. Bioavailability
f. Bioequivalent
g. Plasma protein binding
h. First-pass effect
i. Enterohepatic recirculation
2. Give 2 factors affecting drug permeation. Describe how it affects absorption of
the drug (4 points)
3. Phase I reaction is also known as ______________.
4. Phase II reaction is also known as ______________.
5. Metabolism is also called _____________.
6. Describe and explain what happens if: (3 points each)
a. Infants were given Chloramphenicol
b. Sulfonamides were prescribed to Egyptians
c. Morphine was taken with Ketoconazole
d. A G6PD-deficient patient was prescribed with Primaquine
e. A patient taking oral contraceptive pills has chronic alcoholism
7. What are the different reactions of Phase II Metabolism? Give at least one
example of drugs each. (12 points)
8. It is the major excretory organ of the body.
9. Give 4 other modes of excretion of drugs.