Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
blo
od
e
Blood Flow phrin Find an error?
o r e pine etic) email dkm2112@columbia.edu
N pat h
(Sym iotensin
K Na Ang II
Afferent Arteriole
Glucose
Amino
Acids ATP ANP
Phosphate, ~ 3% of NA
in
gland
Lactate, or +r
Prosta ine
ea
m
citrate bs
a
or
Gl
p
b
& Do
uc
Na
ed
Am
os
rent Arteriole
-F
85% of reabsorbed HCO3- (if CO2 from tubule)
e
in
t.
ine
Late Distal
o
secre
Ac
Na
Ph cta e,
Tubule &
Tun
id
JGA
la trat
os te,
Renin
Collecting Duct
in
ci
ph or
Na ,
-Intercalated &
g Site
at
e
Principal Cells
Effe
H2O imp. w/o ADH
Early Proximal H2O permeable
Tubule with ADH
Isosm. abs. Na
be
d
Early Distal
or
H
+
67 b s Tubule
+
load-depend.
%
A + r c +
H of N diu blo H20 imp. Reabsorb K
O3
of
-
5% d e Dilutes
Na + a
i H excretion
HCO -3 + H + ~ iaz NaCl abs.
Th Aldost. stimd
Na+
H 2 CO 3
H 2 PO 4- excret.
nd K+ reabsorbed
Cl - NH 4+ excret.
New HCO3- (if NH4+ excreted)
ic)
H 2CO 3 Cl -
Furosemide (loop diuret
c.a. IV (blocked by ace
K+
(HPO4 or )
carbonic
anhydrase II AT
P K Na+
CO 2 + H2 O
2-
CO 2+ H2 O
Na ATP
K+
reabsorbed (if not blocked)
NH3 + H+
blocks
HCO-3 + H+ H+
tazolamide)
(excreted)
K
NH +4
ATP Principal Cell
K Cl - ATP
Secrete K +
Na
Formate-
(or H2 PO4 )
Cl- Add aquaporin2
25% of Na+ and 20% of K+
+
Na, K+ ADH R
-
-
Cl H2O
Cl - Gs
ATP H2O
Thick
K+ AC
(inhibit aldost. effect)
K -sparing diuretics ANP also blocks
Ascending
Limb cAMP
Angiotensin II Stimulated
load-depend.
PKA
Aldosterone Stimulated H2O imp.
Dilutes phosphoryln
ADH (vasopressin) Stimulated
ANP Stimulated Na+
Na
Sympathetic (Norepi.) Stimulated ATP
K+
Thin Ascending Limb K
H2O impermeable
Vasodilator
Vasoconstrictor Aldosterone increases # of:
Major effect 1. Na+ channels
Minor effect 2. Na+-K +-ATPase pumps
insignificant, unless lots o stim. 3. K + channels