( )

,

31.02.03
(
31.10.2016 . 13,
358 01.11.2016 .)

2018

- -
www.phoenixbooks.ru
 577:616(075.32)
53.4723
326
33

:

... -
, ,
;

. ..-
,
:
.., .., .., .., ..,
.., ..

33 :
. / . . [ .] ; . . . ,
. . . / : , 2018. 427, [1] . : .,
[4] . . ( ).
ISBN 978-5-222-28627-2

-
, ( -
) -
. -
, , -

. , ,
-
. , -
, , , -
, , . -
.
(-
, ) (, , -
).

, 31.02.03 .

577:616(075.32)
53.4723
, 2017
ISBN 978-5-222-28627-2 : , 2017

- -
www.phoenixbooks.ru







/ /







2--1 2--1
-6- -6-
-

()

-





- , -

- ,
, , -

3

- -
www.phoenixbooks.ru


-
-

-





-













-

4

- -
www.phoenixbooks.ru


( . EDTA) ethylenediaminetetraacetic acid
( )

BASO% (BA%)
BASO# (BA#)
CD cluster of differentiation ( )
CSF colony-stimulating factor (
)
EOS% (E%)
EOS# (E#)
G glycoprotein ()
GRN% (Gr%)
GRN# (Gr#)
CV coefficient of variation ( )
Hb (HGB) hemoglobin ()
HFR% high fluorescence ratio ( -
)
HLA-DR human leukocytes antigens (HLA)
II
HCT hematocrit ()
Ig immunoglobulin ()
IL interleukin ()
IPF immature platelet fraction ( -
)
IRF immature reticulocyte fraction (
)
LFR% low fluorescence ratio (
)
LYM% (LY%)

5

- -
www.phoenixbooks.ru


LYM# (LY#)
MCH mean corpuscular hemoglobin (
)
MCHC mean corpuscular hemoglobin concentration (-
)
MCV mean corpuscular volume ( -
)
MCVr mean cell volume reticulocytes (
)
MFR% middle fluorescence ratio (
)
MID middle ( )
MON% (MO%)
MON# (#)
MPV mean platelet volume ( )
MSRV mean sphered reticulocyte volume (
, -
)
MTHFR
NEUT% (NE%)
NEUT# (NE#)
NRBC nucleated red blood cells (- -
)
PAI plasminogenactivatorinhibitor ( -
)
PDW platelet distribution width (
)
PLT platelet ( )
PCT platelet crit ()
RET%
RET#
RBC red blood cells ( )
RDW red cell distribution width (
)

6

- -
www.phoenixbooks.ru


RPI reticulocyte production index (

)
t- tissue plasminogen activator (
)
WBC white blood cells ( )

- -
www.phoenixbooks.ru
 1.

,
-
:
(I ), (II )
(III ) -
-, ,
(IV ).
-
()
(-, -
.),
.
, , ,
( ),
( ) -
. -
, -

, ,
.
, ..-
.. (1973), -
3 : ( )
(12% ),
(2540%) (6075%).
2005. (.., .1) -
4 .

8

- -
www.phoenixbooks.ru
 1.

()
, -
.
-
. - ,
, in vivo -
in vitro.

(I ) : -
, ( )
; - , ( -
) ;
- .
-
(- ),
.

.
; -
. -
.
( 90%) -
G0;
G1-
S-. ,

1 100.
.
- -
-.
--
(II ).
- : - , -
; -

9

- -
www.phoenixbooks.ru


-
, ; - ,
, , -
.
- .
, -,
, ..
, -
(-).
--
(III )
. - --
: -,
- - - -
,
; - --
(); - -
.
-
(): - , -
, - ,
. - -,
in vitro .
- -
, - -
.
-
,
.
-
,
.
(IV -
) , .

10

- -
www.phoenixbooks.ru
 1.

, -
, -
,
. ,
, , , .
-
, -
.
,
;
(, -
); ; ;
.
, ;

,
. -
,
,
.
-
,
(, -
, , .).
, , .
, -
, , ,
.
- -,
, . . -
- -,
- - -
(- -

11

- -
www.phoenixbooks.ru


). -
, .
.
-
() ,
( )
, -
.
().
, -
,
.
,
. -

-, -
,
, ,
,
.
-


(
).
, -


,
(IL) 3, -,
(SCF), IL-1, IL-6, IL-11 -
, , -
, ,

12

- -
www.phoenixbooks.ru
 1.

(GM-CSF),

.
,
,
-
-
,
(G-CSF), -
(M-CSF),
(Meg-CSF),
-, - .
- --
IL-5, -
. ,
() IL-6,
.
, -
,
,
.
-

,
-
. ,

, -

.

13

- -
www.phoenixbooks.ru


1

1.
?
2. ?
3. -
?
4. IV
?
5.
?
6.
()?
7. ?
8.
?
9.
?
10. -
?

1. :
) ,
;
) - ;
) .
2. :
) ;
) ;
) ;
) ( 90% ).

14

- -
www.phoenixbooks.ru
 1.

3. :
) ;
) ;
) ;
) ;
) .

4. ,
, :
) ;
) ;
) .

5. ,
, :
) ;
) ;
) ;
) -.

15

- -
www.phoenixbooks.ru
 2.

2.1.

, -
, , -

(
7% ),
(, ),
.
, -
,
,
.
( , ,
.), ( , -
, , -
), ( ,
, ).
, , -
, 45% ,
, 55%-
. , -
,
, . -
-
, ,
,

16

- -
www.phoenixbooks.ru
 2.

. -

,
.
, ,
.. .

,
;
25, , 1000.
,
-
, ,
, , , -
.

,
.

2.2.

2.2.1.
.
7,28,0, -
, -
(.., .2,),

7.
(4,35,3)1012/,
(3,84,5)1012/, 140160/
121138/ . -
,
4045%, 3642%.

17

- -
www.phoenixbooks.ru


.
.
-.


, -
12 9.
1 32. -

, -
, ,
(.., . 1).
,
. -
.
36 ,
,
, -

(.., .2,). -
90120,

-
, 510% -
.
.
: 90%-
10%
,

. ,
,

18

- -
www.phoenixbooks.ru
 2.

-
.
.
.

- ,
. -
-
.
30 ( .-
3), ,
Kell.
. , -
:
1) , -
,
;
2) -
, , -
, , ;
3) -
-
.

2.2.2.
.
(24 ),
,
.
, -
, (.., . 3).

.

19

- -
www.phoenixbooks.ru


-
, , , , ,
. ,
,
.
(, -
), - (,
,
) (-
, -
).
-
,
, ,
,
,
.
(170350)109/ .
. -
(
9095%) 23,
, () - ,
() -
. (
1%) 34 ,
, ,

. (25%)
23, , ,
,
() . -
(12%) (35), ,
,
,

20

- -
www.phoenixbooks.ru
 2.

.
( 0,02%) 24 -
-
,
( ).
.
. -

(. ., .1).
-
,
, -
.
( )
, .
710,
, .
.
,
.
:
1) -
,

;
;
2) -
, -

;
3) - -
- -
() (
);

21

- -
www.phoenixbooks.ru


4)

(I, II, III, V, VII, X);
5) -
, ,
;
6) -
, , ,
.;
7)
( );
8) -
(, .); -

.

14 , -
.

2.2.3.
.
(), -
(49)109/,
.
1016, , -

- (. 2.1, ., .4,,). -
-
35 ( , ., .4,)
,
S- ( , ., .4,);
, .
-

22

- -
www.phoenixbooks.ru
 2.

(.., .4,).
10 70%
, 4365%,
25%.
.
,
46 ,
, ,
,
(. ., . 1). ,
,
35, ,
, -
.. ,
.
-
.

510 ( ),
,

23. . -
, -
1420.
, .
. -
,
.
,
, ,
.
, -
, .
-

23

- -
www.phoenixbooks.ru


,
.
,
, -

- (
).
.
-
(, , ),
.
,
, - -
,
,
.
,
,
. , -
, ,
.

2.2.4.
. -

1016, -
( )
(. 2.1). ,
, , -
. -
2 (-
) 3 ; ,
(. ., . 5).
15%.

24

- -
www.phoenixbooks.ru
 . 2.1


- -
-

/
- - / -
- -
-
() -
/-


1 2 3 4 5 6 7 8 9 10
- 1220 - - 23 / /
- (-
/- )
,
-

www.phoenixbooks.ru

- 1825 - - 12 / +/
( - - - (- - - -

/- )
-- (,
)
),

- -


 2.1
1 2 3 4 5 6 7 8 9 10
- 1018 , - - / - / -
- /- -
- ()
--
- 1012 - - - / / .
- /- -
-
,
- 1016 - - / / -
- , /-
- - -
- .

www.phoenixbooks.ru
,
- 1015

- 25-

, -
--
-
() -
-
( -

)

- -
- 1420 , - - / / ,
( - -
, - /-
, ,
) - -
,
-

 2.1
1 2 3 4 5 6 7 8 9 10
- 1215 - - / /
- /-
- -
-

-

- 810 - - / /
- /- -
- -

78 - - ( /

www.phoenixbooks.ru
- - -- ) /
/- -

- 812 - - - +/+
- /- -
-
(

- -
)


.
,
, -
,
, , (..,
.1). 34,
-
. 612
,
.
,
,
. -
. ,

814.
. -
,
, ,
, , ,
.

,
, , -
, .


.
. , -

, -
(, , ) -
-
,

28

- -
www.phoenixbooks.ru


...............................................................................................3

1. ...............................8
1.............................................................14

2. ...........................16
2.1.
..........................................................................16
2.2.
.............................................................17
2.2.1.....................................................................................17
2.2.2....................................................................................19
2.2.3. ...................................................22
2.2.4. ...................................................24
2.2.5. ........................................................29
2.2.6.....................................................................................30
2.2.7........................................................................................33
2.3.
.................................................................................35
2.............................................................37

3. ..............................................................................42
3.1. ..................................................................................42
3.2. : ,
.......................................44
3.3. AB...................................................50
3.3.1. ..............................................52
3.3.2. - --.............................58
3.4. ..............................................62
3.4.1. D ..........................................................64
3.5. ......................68
3.5.1.
..........................................69
3.5.2. - ...........73
3.5.3. ..........................................78
3.5.4.
...............................................................................89
3.5.5.
...............................................91

424

- -
www.phoenixbooks.ru


3.5.6.
.......................................................94
3.5.7.-
...............................................................97
3.6. .................................98
3...........................................................103

4. .............................................110
4.1.
.........................................................................................110
4.1.1. ...............................................................111
4.1.2. ,
...............................................................................115
4.1.3. ,
..............116
4.1.4. .........118
4.2. ...........................122
4.2.1. ................122
4.2.2. .................125
4.2.3. .........................................................133
4.2.4.
,
................................................133
4.2.5. ...............137
4.2.6. ()......141
4.2.7.
.....................................................................................145
4.2.8.
.............................................................148
4.2.9. ............151
4.2.10.

( ).......................152
4.2.11. ..............................................................153
4.3. ..........................................156
4.3.1. ...............................................156
4.3.2. ......157
4.3.3.
.............................................................158
4.3.4.
..........................................................................159
4.3.5.
................................................................................161
4.3.6. .................................163

425

- -
www.phoenixbooks.ru


4.4. .......163
4.4.1. ...................................................164
4.4.2. ................................................172
4.4.3. ...................................................174
4.4.4. ......................................................177
4.5. ..........182
4.5.1.
........................................................182
4.5.2.
Sheehan, Storey............................................................................184
4.5.3.
Goldberg, Barka...........................................................................185
4.5.4.
cManus (- PAS-).....................................186
4.5.5. -
ayhoe, Quaglino.........................................187
4.6.
.......................................................189
4.6.1.
...........................................................189
4.6.2.
.........................................190
4.6.3.

.................................................................................191
4.7.
............................................................192
4...........................................................195

5. . ...................205
5.1. .......................................205
5.2. .......................................................................210
5.3. .......................................................................215
5.3.1. ....................................215
5.3.2. .............................................................218
5.3.3. () .........................234
5.3.4.,
.......................................................................236
5.4. ...........................................................................238
5.4.1. ......................................................239
5.4.2. () .................248
5.4.3.....................................................................................249
5.4.4. .........................................250
5.5. .........................................................................251

426

- -
www.phoenixbooks.ru


5.5.1. (12- ) ......251

5.5.2. ............................256
5.6.........................................................................................257
5...........................................................260

6. ,
, .........................................................................................271
6.1. ..............................271
6.2...........................................................................................276
6.3. .......................................................................279
6.4..............................................................................................286
6...........................................................296

7. . .........................301
7.1. ...........................................301
7.2. ..........................................................305
7.3. .....................................................................................307
7.3.1. ...........................................307
7.3.2. -
............................................................................................309
7.3.3. ...........................................312
7.3.4. ..................................................317
7.3.5.
...............................................................................324
7.4. ..........................................................................324
7.4.1. .................................324
7.4.2.-
...................................................................325
7.5.................................................................................................335
7...........................................................337

8. .......348
8.1. .................................................349
8.1.1. ......................................349
8.1.2. ................................................350
8.1.3. ...........................352
8.1.4. .........................................358
8.1.5. .........................................................362
8.2.
.................................................................................364
8.3. ......367
8.4. ............370
8.5. ()
.....................................................................377

427

- -
www.phoenixbooks.ru


8.5.1. ....................................378
8.5.2. .........................378
8.5.3. ...................380
8.5.4. ......................381
8.5.5.
...................................................384
8.5.6.
.............................................................................389
8.5.7. .....................................................392
8.6. ......393
8.7. -....................................396
8...........................................................398

9. -
......................................................................404
9.1. .................404
9.2.
- ................................405
9.3.
- ................................408
9...........................................................409

..........................................................................411

.............................................................412

- -
www.phoenixbooks.ru


,
,
,
,
,
,

..
..
..

84108/32. .
. . . 22,68
1 500 . . 2222

e-mail:
maribas.fenix@gmail.com

- -
www.phoenixbooks.ru