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Causes of Hypoxia
1. Ventilation
2. Diffusion of gases
3. Pulmonary capillary blood flow
4. Carriages of gases by blood
5. Tissue extraction of O2
Ventilation
A cyclical movement of ambient air into and out of lung
Accomplished by
Contraction & relaxation of respiratory muscles
Elastic recoil of lungs
During quiet breathing, 2/3 of inspired air reaches alveoli (VA). The rest entered less well
perfused sites (VD), aka wasted ventilation.
Total ventilation (L/min) = VA+VD
Static lung volume: Depends on compliance of both chest wall & lung
Diffusion of gases
Passive movement of O2 abd CO2 between alveolar gas and pulmonary capillary blood
Depends on:
Matching of ventilation and blood flow
Diffusion of gas from alveolus to red blood cell
Availability of Hb
Carriages of gases
O2 transported mainly by Hb and some in solution
CO2 transported by solution (as HCO3-) and Hb
Important factors
Influences in oxygen dissociation curve
Control factors Decrease Increase
Temperature Left Right shift
2.3-BPG Left Right shift
P(CO2) Left shift Right shift
pH Right shift (acidosis) Left shift (alkalosis)