Fda 2010 N 0100 0005

FINAL REPORT
Volume 1 of 16
(Text, Figures, and Summary Tables 1-44)
STUDY TITLE
A DIETARY DEVELOPMENTAL
NEUROTOXICITY STUDY OF BISPHENOL A IN RATS
STUDY NUMBER
WIL-186056
DATA REQUIREMENT
U.S. EPA OPPTS Guideline 870.6300

OECD Guideline 426
STUDY DIRECTOR
Donald G. Stump, PhD, DABT
STUDY INITIATION DATE
26 June 2008
STUDY COMPLETION DATE
30 September 2009
PERFORMING LABORATORY
WIL Research Laboratories, LLC

1407 George Road
Ashland, OH 44805-8946
SPONSOR
Polycarbonate/BPA Global Group

American Chemistry Council
1300 Wilson Boulevard
Arlington, VA 22209
Page 1 of 4796
WIL-186056 Bisphenol A
COMPLIANCE
STATEMENT
This study, designated WIL- 186056, was conducted in compliance with the United States
Environmental Protection Agency (EPA) Good Laboratory Practice Standards
(40 CFR Part 792), 18 September 1989; the Organisation for Economic Cooperation and
Development (OECD) Principles of Good Laboratory Practice [C(97) 186Rinal1,
26 November 1997, with the following exceptions. The analysis of the phytoestrogen
content in the diet (Appendix E) was not performed according to GLPs. The
characterization of the internal standard used for the analyses of test diets was unknown.
In addition, although hlly trained, completion of training was not documented for three
technicians that used the Zymark TurboVap LV Evaporator and one technician that used
the Agilent GC-MS system during the analyses of dietary formulations.
This study was also conducted in accordance with the standard operating procedures of
WIL Research Laboratories, LLC and the protocol as approved by the Sponsor.
The protocol was designed to be in accordance with the United States EPA Health Effects
Test Guidelines OPPTS 870.6300 Developmental Neurotoxicity Study, August 1998 and
the OECD Guideline for Testing of Chemicals, Guideline 426, Developmental
Neurotoxicity Study, 16 October 2007.

Director, Developmentaland
Reproductive Toxicology
Study Director
Page 2 of 4796
TABLE OF CONTENTS
VOLUME 1 Page
Compliance Statement ........................................................................... 2

Table Of Contents.................................................................................. 3
Index Of Figures .................................................................................... 8
Index Of Tables.................................................................................... 10
Index Of Appendices............................................................................ 14
1. Summary .............................................................................................. 20
2. Introduction ......................................................................................... 24
2.1. General Study Information..................................................................... 24
2.2. Key Study Dates .................................................................................... 25
2.3. Principal Investigators And Test Sites.................................................... 25
3. Study Design......................................................................................... 26
4. Experimental Procedures - Materials And Methods .......................... 28
4.1. Test Substances And Vehicle ................................................................. 28
4.1.1. Test Substance Identification ................................................................. 28
4.1.2. Carrier Identification.............................................................................. 28
4.1.3. Preparation............................................................................................. 29
4.1.4. Sampling And Analysis ......................................................................... 31
4.2. Test System ........................................................................................... 31
4.3. Organization Of Test Groups, Exposure Levels, And Treatment
Regimen ................................................................................................ 32
4.4. F0 Maternal Generation.......................................................................... 33
4.4.1. Animal Receipt And Acclimation .......................................................... 33
4.4.2. Animal Housing..................................................................................... 34
4.4.3. Diet, Drinking Water, And Maintenance ................................................ 34
4.4.4. Environmental Conditions...................................................................... 35
4.4.5. Assignment Of Animals To Treatment Groups And Breeding
Procedures ............................................................................................. 36
Page 3 of 4796
VOLUME 1 (continued) Page
5. Parameters Evaluated.......................................................................... 38
5.1. F0 Observations...................................................................................... 38
5.1.1. Clinical Observations And Survival ....................................................... 38
5.1.2. Detailed Clinical Observations............................................................... 38
5.1.3. Body Weights ........................................................................................ 39
5.1.4. Food Consumption And Test Substance Consumption ........................... 39
5.1.5. Parturition.............................................................................................. 39
5.1.6. Anatomic Pathology............................................................................... 40
5.1.6.1. Macroscopic Examinations .................................................................... 40
5.1.6.2. Organ Weights....................................................................................... 41
5.1.6.3. Microscopic Examinations ..................................................................... 41
5.2. F1 Litter Parameters ............................................................................... 41
5.2.1. Litter Viability And Deaths.................................................................... 41
5.2.2. Litter Reduction..................................................................................... 42
5.2.3. Clinical Observations............................................................................. 42
5.2.4. Body Weights ........................................................................................ 42
5.2.5. Sex Determination ................................................................................. 43
5.2.6. Calculation Of Litter Parameters............................................................ 43
5.2.7. Weaning And Selection ......................................................................... 43
5.2.8. Developmental Landmarks, Sensory Function, And
Neurobehavioral Testing ........................................................................ 44
5.2.8.1. Surface Righting Response .................................................................... 45
5.2.8.2. Balanopreputial Separation (Subset A)................................................... 45
5.2.8.3. Vaginal Patency (Subset A) ................................................................... 45
5.2.8.4. Detailed Clinical Observations (Subset A) ............................................. 45
5.2.8.5. Auditory Startle Response (Subset A) .................................................... 46
5.2.8.6. Motor Activity (Subset A)...................................................................... 47
5.2.8.7. Biel Maze Swimming Trials (Subsets A And B) .................................... 47
5.2.9. Macroscopic And Microscopic Examinations ........................................ 49
Page 4 of 4796
5.2.9.1. Offspring Not Selected For Behavioral Evaluations (Subset D).............. 49

5.2.9.2. Offspring Euthanized Following Completion Of The PND 22
Learning And Memory Assessments (Subset B)..................................... 49
5.2.9.3. Neuropathology (Subsets A And C) ....................................................... 50
5.2.9.3.1. Macroscopic Examination...................................................................... 50
5.2.9.3.2. Microscopic Examination ...................................................................... 50
5.2.9.3.3. Morphometric Analysis.......................................................................... 53
5.3. Statistical Methods................................................................................. 54
5.3.1. Body Weight And Food Consumption Data ........................................... 55
5.3.2. Organ Weights....................................................................................... 57
5.3.3. Developmental Landmarks .................................................................... 57
5.3.4. Motor Activity ....................................................................................... 58
5.3.4.1. Motor Activity Within Sessions - PND 13, 17, And 21 .......................... 58
5.3.4.2. Motor Activity Across Sessions - PND 13, 17, And 21 .......................... 58
5.3.4.3. Motor Activity Within Session - PND 61 ............................................... 59
5.3.5. Auditory Startle Response...................................................................... 59
5.3.5.1. Auditory Startle Response Within Session - PND 20.............................. 59
5.3.5.2. Auditory Startle Response Within Session - PND 60.............................. 60
5.3.6. Biel Maze .............................................................................................. 60
5.3.6.1. Biel Maze - PND 22............................................................................... 60
5.3.6.2. Biel Maze - PND 62............................................................................... 61
5.3.7. Brain Measurements And Brain Morphometry....................................... 62
5.4. Data Retention ....................................................................................... 64
6. Results .................................................................................................. 65
6.1. Analytical Chemistry ............................................................................. 65
6.2. F0 Maternal Generation.......................................................................... 66
6.2.1. Pregnancy Status.................................................................................... 66
6.2.3. Detailed Clinical Observations............................................................... 67
Page 5 of 4796
6.2.4. Body Weights ........................................................................................ 68

6.2.4.1. Gestation ............................................................................................... 68
6.2.4.2. Lactation................................................................................................ 68
6.2.5. Food Consumption................................................................................. 69
6.2.5.1. Gestation ............................................................................................... 69
6.2.5.2. Lactation................................................................................................ 70
6.2.5.3. Test Substance Consumption ................................................................. 70
6.2.6. Gestation Length And Parturition........................................................... 71
6.2.7. Anatomic Pathology (F0)........................................................................ 71
6.2.7.1. Macroscopic Examinations .................................................................... 71
6.2.7.2. Organ Weights....................................................................................... 72
6.2.7.3. Microscopic Examinations ..................................................................... 72
6.3. F1 Litter Data ......................................................................................... 73
6.3.1. PND 0 Litter Data And Postnatal Survival ............................................. 73
6.3.2. General Physical Condition.................................................................... 73
6.3.3. Offspring Body Weights ........................................................................ 74
6.3.4. Necropsies Of Pups Found Dead Or Euthanized In Extremis.................. 75
6.3.5. Necropsies Of Pups Euthanized Due To Death Of Dam, Sex Ratio
Criteria Not Met, Or On PND 21 Not Selected For
Neuropathological Evaluation ................................................................ 76
6.4. Developmental Landmarks .................................................................... 76
6.4.1. Surface Righting Response .................................................................... 76
6.4.2. Balanopreputial Separation .................................................................... 77
6.4.3. Vaginal Patency..................................................................................... 77
6.5. F1 Generation......................................................................................... 78
6.5.2. Body Weights ........................................................................................ 79
6.5.3. Detailed Clinical Observations (Subset A) ............................................. 79
6.5.4. Motor Activity (Subset A)...................................................................... 81
6.5.5. Auditory Startle Test (Subset A) ............................................................ 81
Page 6 of 4796
6.5.6. Biel Maze Swimming Trials (Subsets A And B) .................................... 82

6.5.7. Macroscopic Examinations .................................................................... 83
6.5.7.1. Unscheduled Deaths............................................................................... 83
6.5.7.2. Animals Euthanized Following PND 22 Learning And Memory
(Subset B).............................................................................................. 83
6.5.8. Neuropathology ..................................................................................... 84
6.5.8.1. PND 21 (Subset C) ................................................................................ 84
6.5.8.1.1. Macroscopic Examinations .................................................................... 84
6.5.8.1.2. Brain Weights/Brain Measurements....................................................... 84
6.5.8.1.3. Qualitative Histopathology And Brain Morphometry............................. 84
6.5.8.2. PND 72 (Subset A) ................................................................................ 85
6.5.8.2.1. Macroscopic Examinations .................................................................... 85
6.5.8.2.2. Brain Weights/Brain Measurements....................................................... 86
6.5.8.2.3. Qualitative Histopathology And Brain Morphometry............................. 86
7. Discussion ............................................................................................. 87
8. Conclusions .......................................................................................... 89
9. Key Study Personnel And Report Submission.................................... 90
10. Quality Assurance Unit Statement ...................................................... 92
10.1. Phases Inspected .................................................................................... 92
10.2. Approval................................................................................................ 98
11. References ............................................................................................ 99
12. Deviations From The Protocol........................................................... 102
Page 7 of 4796
INDEX OF FIGURES
1. Summary Of Body Weights During Gestation [G] (F0 Females)............................ 107
2. Summary Of Body Weights During Lactation [G] (F0 Females)............................ 108
3. Summary Of Test Substance Consumption During Gestation [Mg/Kg/Day]

(F0 Females).............................................................................................................. 109
4. Summary Of Test Substance Consumption During Lactation [Mg/Kg/Day]

(F0 Females).............................................................................................................. 110
5. Summary Of Offspring Weights [G] (F1 Males) ..................................................... 111
6. Summary Of Offspring Weights [G] (F1 Females).................................................. 112
7. Summary Of Post-Weaning Body Weights [G] (F1 Males) .................................... 113
8. Summary Of Post-Weaning Body Weights [G] (F1 Females)................................. 114
9. Summary Of Motor Activity Total Counts By Session

(F1 Combined Sexes - PND 13, 17, and 21) ............................................................ 115
10. Summary Of Motor Activity Total Counts (F1 Combined Sexes - PND 13).......... 116

(F1 Males - PND 61)................................................................................................. 119

(F1 Females - PND 61) ............................................................................................. 120
15. Summary Of Motor Activity Total Counts (F1 Males - PND 61) ........................... 121
16. Summary Of Motor Activity Total Counts (F1 Females - PND 61)........................ 122
17. Summary Of Startle Response Data [Max] (F1 Combined Sexes - PND 20) ......... 123
18. Summary Of Startle Response Data [Max] (F1 Combined Sexes - PND 60) ......... 124
Page 8 of 4796
19. Summary Of Biel Maze Data - Mean No. Of Errors

(F1 Combined Sexes - PND 22) ............................................................................... 125
20. Summary Of Biel Maze Data - Mean No. Of Errors (F1 Males - PND 22) ............ 126
21. Summary Of Biel Maze Data - Mean No. Of Errors (F1 Females - PND 22)......... 127
22. Summary Of Biel Maze Data - Mean No. Of Errors

(F1 Combined Sexes - PND 62) ............................................................................... 128
23. Summary Of Biel Maze Data - Mean No. Of Errors (F1 Males - PND 62) ............ 129
24. Summary Of Biel Maze Data - Mean No. Of Errors (F1 Females - PND 62)......... 130
25. Summary Of Brain Morphometry [Level 1] (F1 Combined Sexes - PND 21)........ 131
Page 9 of 4796
INDEX OF TABLES
SUMMARY DATA - F0 GENERATION

1. Summary Of Maternal Survival And Pregnancy Status (F0)................................... 138
2. Summary Of Clinical Findings: Total Occurrence/No. Of Animals

(F0 - Daily Examinations)......................................................................................... 139
3. Summary Of Detailed Clinical Observations (F0 - Gestation) ................................ 142
4. Summary Of Detailed Clinical Observations (F0 - Lactation)................................. 152
5. Summary Of Body Weights During Gestation [G] (F0) .......................................... 164
6. Summary Of Body Weight Changes During Gestation [G] (F0)............................. 166
7. Summary Of Body Weights During Lactation [G] (F0) .......................................... 168
8. Summary Of Body Weight Changes During Lactation [G] (F0) ............................. 170
9. Summary Of Food Consumption During Gestation [G/Animal/Day] (F0) ............. 172
10. Summary Of Food Consumption During Lactation [G/Animal/Day] (F0) ............. 174
11. Summary Of Calculated Gestation Test Substance Consumption

[Mg/Kg/Day] (F0)..................................................................................................... 176
12. Summary Of Calculated Lactation Test Substance Consumption

[Mg/Kg/Day] (F0)..................................................................................................... 178
13. Summary Of Gestation Lengths [Days] (F0) ........................................................... 180
14. Summary Of Macroscopic Findings (F0 - Unscheduled Death).............................. 181
15. Summary Of Macroscopic Findings (F0 - Failed To Deliver)................................. 182
16. Summary Of Macroscopic Findings (F0 - Pup Sex Ratio Criteria Not Met) .......... 183
17. Summary Of Macroscopic Findings (F0 - Lactation Day 21).................................. 184
18. Summary Of Implantation Sites (F0)........................................................................ 186
Page 10 of 4796
19. Summary Of Organ Weights And Organ Weights Relative To Body Weights
(F0 - Lactation Day 21)............................................................................................. 187
20. Summary Of Microscopic Findings (F0 - Unscheduled Death) .............................. 189
21. Summary Of Microscopic Findings (F0 - Failed To Deliver).................................. 190
22. Summary Of Microscopic Findings (F0 - Pup Sex Ratio Criteria Not Met) ........... 191
23. Summary Of Microscopic Findings (F0 - Lactation Day 21) .................................. 192
SUMMARY DATA - F1 LITTERS

24. Summary Of PND 0 Litter Data (F1) ....................................................................... 195
25. Summary Of Postnatal Survival [% Per Litter] (F1) ................................................ 196
26. Summary Of Pup Clinical Observations (F1)........................................................... 198
27. Summary Of Offspring Weights [G] (F1) ................................................................ 200
28. Summary Of Offspring Weight Changes [G] (F1)................................................... 209
29. Summary Of Pup Necropsy Findings

(F1 - Found Dead Or Euthanized In Extremis Pups)................................................ 215
30. Summary Of Pup Necropsy Findings (F1 - Pups Euthanized Due To Death
Of Dam, Sex Ratio Criteria Not Met, Or On PND 21)............................................ 216
SUMMARY DATA - F1 DEVELOPMENTAL LANDMARKS

31. Summary Of Developmental Landmarks - Surface Righting Response (F1).......... 217
32. Summary Of Developmental Landmarks - Balanopreputial Separation

(F1 - Subset A) .......................................................................................................... 218
33. Summary Of Developmental Landmarks - Vaginal Patency

(F1 - Subset A) .......................................................................................................... 219
Page 11 of 4796
SUMMARY DATA - F1 GENERATION

(F1 Males - Subsets A And B).................................................................................. 220

(F1 Females - Subsets A And B) .............................................................................. 222
36. Summary Of Body Weights [G] (F1 - Subset A) ..................................................... 224
37. Summary Of Body Weight Changes [G] (F1 Males - Subset A)............................. 230
38. Summary Of Body Weight Changes [G] (F1 Females - Subset A) ......................... 232
39. Summary Of Detailed Clinical Observations (F1 - Subset A) ................................. 234
40. Summary Of Motor Activity Counts Across Sessions - Total Counts

(F1 - Subset A) .......................................................................................................... 291
41. Summary Of Motor Activity Counts Within Sessions - Total Counts

(F1 - Subset A) .......................................................................................................... 294
42. Summary Of Startle Response Data - Max [Newtons] (F1 - Subset A) .................. 318
43. Summary Of Biel Maze Swim Trials - Mean Number Of Errors

(F1 - PND 22 - Subset B).......................................................................................... 326
44. Summary Of Biel Maze Swim Trials - Mean Number Of Errors

(F1 - PND 62 - Subset A).......................................................................................... 339
VOLUME 2
45. Summary Of Macroscopic Findings (F1 Males - Unscheduled Deaths) ................. 351
46. Summary Of Macroscopic Findings (F1 Females - Unscheduled Death) ............... 352
47. Summary Of Macroscopic Findings

(F1 Males - Scheduled Necropsy - Subset B)........................................................... 353

(F1 Females - Scheduled Necropsy - Subset B) ....................................................... 354

(F1 - Animals Selected For Neuropathology - PND 21 - Subset C) ........................ 355
Page 12 of 4796
50. Summary Of Brain Weights And Measurements

51. Summary Of Microscopic Findings

52. Summary Of Brain Morphometry [CM]


(F1 - Animals Selected For Neuropathology - PND 72 - Subset A)........................ 371
54. Summary Of Brain Weights And Measurements

55. Summary Of Microscopic Findings

56. Summary Of Brain Morphometry [CM]

Page 13 of 4796
INDEX OF APPENDICES
A. Individual Animal Data............................................................................................ 396
INDIVIDUAL DATA - F0 GENERATION

A1. Individual Clinical Observations (F0 - Daily Examinations) ...................... 397
VOLUME 3
A2. Individual Detailed Clinical Observations (F0 - Gestation) ........................ 656
A3. Individual Detailed Clinical Observations (F0 - Lactation)......................... 728
A4. Individual Body Weights During Gestation [G] (F0) .................................. 800
A5. Individual Body Weight Changes During Gestation [G] (F0)..................... 806
A6. Individual Body Weights During Lactation [G] (F0) .................................. 818
A7. Individual Body Weight Changes During Lactation [G] (F0)..................... 824
A8. Individual Food Consumption During Gestation [G/Animal/Day]

(F0)................................................................................................................ 830
A9. Individual Food Consumption During Lactation [G/Animal/Day]

(F0)................................................................................................................ 836
A10. Individual Calculated Gestation Test Substance Consumption

[Mg/Kg/Day] (F0) ........................................................................................ 842
A11. Individual Calculated Lactation Test Substance Consumption

[Mg/Kg/Day] (F0) ........................................................................................ 848
A12. Individual Gestation Lengths [Days] (F0) ................................................... 854
A13. Individual Animal Cause Of Death (F0 - Unscheduled Death)................... 855
A14. Individual Macroscopic And Microscopic Findings

(F0 - Unscheduled Death) ............................................................................ 856

(F0 - Failed To Deliver)................................................................................ 857
Page 14 of 4796

(F0 - Pup Sex Ratio Criteria Not Met) ......................................................... 859

(F0 - Lactation Day 21) ................................................................................ 863
VOLUME 4
A18. Individual Implantation Sites (F0).............................................................. 1003
A19. Individual Organ Weights And Final Body Weights [G]

(F0 - Lactation Day 21) .............................................................................. 1009
A20. Individual Organ Weights Relative To Final Body Weights

[G/100 G] (F0 - Lactation Day 21) ............................................................ 1015
INDIVIDUAL DATA - F1 LITTERS

A21. Individual Litter Viability (F1)................................................................... 1021
A22. Individual Pup Viability (F1) ..................................................................... 1045
A23. Individual Postnatal Survival [% Per Litter] (F1) ...................................... 1063
A24. Individual Pup Clinical Observations (F1)................................................. 1069
VOLUME 5
A25. Individual Offspring Weights [G] (F1) ...................................................... 1310
A26. Individual Offspring Weight Changes [G] (F1)......................................... 1417
A27. Individual Pup Necropsy Findings

(F1 - Found Dead Or Euthanized In Extremis Pups) ................................. 1523
A28. Individual Pup Necropsy Findings (F1 - Pups Euthanized Due To

Death Of Dam, Sex Ratio Criteria Not Met, Or On PND 21) .................. 1530
INDIVIDUAL DATA - F1 DEVELOPMENTAL LANDMARKS

A29. Individual Developmental Parameters [Litter Values] -
Surface Righting Response (F1)................................................................. 1548
Page 15 of 4796
A30. Individual Animal Developmental Parameters -

Balanopreputial Separation (F1 - Subset A) .............................................. 1570
A31. Individual Animal Developmental Parameters -

Vaginal Patency (F1 - Subset A) ................................................................ 1582
INDIVIDUAL DATA - F1 GENERATION

A32. Individual Clinical Observations (F1 Males - Subsets A And B).............. 1588
VOLUME 6
A33. Individual Clinical Observations (F1 Females - Subsets A And B) .......... 1648
A34. Individual Body Weights [G] (F1 Males - Subsets A And B)................... 1707
A35. Individual Body Weights [G] (F1 Females - Subsets A And B) ............... 1719
A36. Individual Body Weight Changes [G] (F1 Males - Subsets A And B) ..... 1731
A37. Individual Body Weight Changes [G]

(F1 Females - Subsets A And B)................................................................ 1737
A38. Individual Detailed Clinical Observations (F1 - Subset A) ....................... 1749
VOLUME 7
A38. Individual Detailed Clinical Observations (F1 - Subset A) [continued].... 1967
A39. Individual Motor Activity Counts (F1 - Subset A) .................................... 2183
A40. Individual Startle Response Data (F1 - Subset A) ..................................... 2231
A41. Individual Biel Maze Straight Channel Swim Trials

(F1 - PND 22 - Subset B) ........................................................................... 2255
A42. Individual Biel Maze Swim Trials (F1 - PND 22 - Subset B) ................... 2267
A43. Individual Biel Maze Straight Channel Swim Trials

(F1 - PND 62 - Subset A) ........................................................................... 2291
VOLUME 8
A44. Individual Biel Maze Swim Trials (F1 - PND 62 - Subset A)................... 2305
Page 16 of 4796
A45. Individual Macroscopic Findings (F1 Males - Unscheduled Deaths) ....... 2329
A46. Individual Macroscopic Findings (F1 Females - Unscheduled Death) ..... 2332
A47. Individual Macroscopic Findings

(F1 Males - Scheduled Necropsy - Subset B) ............................................ 2333
A48. Individual Macroscopic Findings

(F1 Females - Scheduled Necropsy - Subset B)......................................... 2467
VOLUME 9
A49. Individual Macroscopic And Microscopic Findings (F1 - Animals

Selected For Neuropathology - PND 21 - Subset C)................................. 2605
A50. Individual Final Body And Brain Weights And Brain Measurements
(F1 - Animals Selected For Neuropathology - PND 21 - Subset C).......... 2878
A51. Individual Brain Weights Relative To Final Body Weights [G/100 G]

(F1 - Animals Selected For Neuropathology - PND 21 - Subset C).......... 2890
A52. Individual Brain Morphometry [CM] (F1 - Animals Selected For

Neuropathology - PND 21 - Subset C)...................................................... 2902
VOLUME 10
A53. Individual Macroscopic And Microscopic Findings (F1 - Animals

Selected For Neuropathology - PND 72 - Subset A) ................................ 2952
A54. Individual Final Body And Brain Weights And Brain Measurements
(F1 - Animals Selected For Neuropathology - PND 72 - Subset A) ......... 3223
A55. Individual Brain Weights Relative To Final Body Weights [G/100 G]

(F1 - Animals Selected For Neuropathology - PND 72 - Subset A) ......... 3235
A56. Individual Brain Morphometry [CM] (F1 - Animals Selected For

Neuropathology - PND 72 - Subset A)...................................................... 3247
Page 17 of 4796
VOLUME 11 Page
B. Certificates Of Analysis (Sponsor-Provided Data)................................................ 3296
C. Analyses Of Dietary Formulations (WIL Research Laboratories, LLC) .............. 3303
D. Nesting Material Analyses ..................................................................................... 3381
E. Feed And Water Analyses...................................................................................... 3388
F. Animal Room Environmental Conditions ............................................................. 3458
G. Scoring Criteria For The Detailed Clinical Observations...................................... 3474
H. Pathology Report (WIL Research Laboratories, LLC).......................................... 3479
I. Peer Review Statement (Consultants In Veterinary Pathology, Inc.).................... 3495
J. Statistical Analysis Summary (BioSTAT Consultants, Inc.)................................. 3499
VOLUME 12
K. WIL Reproductive Historical Control Data Version 2.8m2

[Crl:CD(SD) Rats].................................................................................................. 3623
L. Developmental Neurotoxicity Method Development And Positive Control

Studies (WIL Research Laboratories, LLC) .......................................................... 3633
M. WIL Functional Observational Battery Historical Control Data Version 2.0

[Crl:CD(SD) Rats].................................................................................................. 3846
VOLUME 13
N. Follow-Up Study (A Dietary Study Of Bisphenol A In Rats To Re-Evaluate

Pup Observations From A Developmental Neurotoxicity Study;
WIL-186058).......................................................................................................... 3920
VOLUME 14

WIL-186058) [continued] ...................................................................................... 4236
Page 18 of 4796
VOLUME 15 Page

WIL-186058) [continued] ...................................................................................... 4414
VOLUME 16
O. WIL Motor Activity Historical Control Data Version 1.2 [Crl:CD(SD) Rats]..... 4686
P. WIL Startle Response Historical Control Data Version 1.3

[Crl:CD(SD) Rats].................................................................................................. 4699
Q. WIL Biel Maze Historical Control Data Version 2.1 [Crl:CD(SD) Rats]............. 4708
R. WIL Brain Morphometry Historical Control Data Version 1.2

[Crl:CD(SD) Rats].................................................................................................. 4735
S. Study Protocol And Amendments.......................................................................... 4740
Page 19 of 4796
1. SUMMARY
The objective of this study was to determine the potential of the test substance,
bisphenol A, to induce functional and/or morphological effects to the nervous system of
offspring following exposure of the mother during pregnancy and lactation. The study
was conducted in accordance with and exceeded OECD Test Guideline 426 and U.S.
EPA OPPTS Guideline 870.6300 and was in conformance with Good Laboratory Practice
Regulations (40 CFR Part 792) and the OECD Principles of Good Laboratory Practice
[C(97) 186/Final]. As specified in the guidelines, positive control data, using reference
chemicals to establish the reliability and sensitivity of the test methods at the appropriate
offspring ages used for neurotoxicity endpoints, were developed by WIL Research
Laboratories, LLC and are included in Appendix L.
The test substance, bisphenol A (BPA), was offered at concentrations of 0 (control), 0.15,
1.5, 75, 750, and 2250 parts per million (ppm) on a continuous basis in the diet to
six groups of 24 bred female Crl:CD(SD) rats (F0 dams) daily from gestation day 0
through lactation day 21. The mean test substance consumption in the 0, 0.15, 1.5, 75,
750, and 2250 ppm groups was 0, 0.01, 0.12, 5.85, 56.4, and 164 mg/kg/day,
respectively, during gestation and 0, 0.03, 0.25, 13.1, 129, and 410 mg/kg/day,
respectively, during lactation.
Clinical observations, body weights, and food consumption were recorded at appropriate
intervals. In addition, detailed clinical observations (DCO) were conducted outside of the
home cage on all dams in each group on gestation days 10 and 15 and on lactation
days 10 and 21. All females were allowed to deliver and rear their offspring
(F1 generation) to lactation day 21, at which time the dams were euthanized and
necropsied. The liver and kidneys were weighed and examined microscopically for all
F0 females surviving to the scheduled necropsies.
Clinical observations, body weights, and sex were recorded for the F1 pups at appropriate
intervals. Surface righting response was evaluated for all available F1 pups beginning on
Page 20 of 4796
postnatal day (PND) 2. On PND 4, litters were culled to eight pups/litter

(four pups/sex/litter, when possible).
Following culling, a subset (Subset A) consisting of one pup/sex/litter was assigned to

detailed clinical observations (PND 4, 11, 21, 35, 45, and 60), auditory startle response
(PND 20 and 60), motor activity (PND 13, 17, 21, and 61), and learning and memory using
the Biel maze (PND 62). This same subset of animals was selected for brain weight
measurements on PND 72; of these, one pup/litter (10 pups/sex) from all groups was
selected for neuropathological and morphometric evaluations on PND 72. A second subset
(Subset B) consisting of one pup/sex/litter was selected for learning and memory using the
Biel maze on PND 22. A third subset (Subset C) consisting of one pup/sex/litter was
selected for brain weight evaluations on PND 21; of these, one pup/litter (10 pups/sex) from
all groups was selected for neuropathological and morphometric evaluations on PND 21.
Developmental landmarks (balanopreputial separation or vaginal patency) were evaluated
for all F1 animals in Subset A. All F1 animals not selected for behavioral evaluations
(Subset D) were euthanized and necropsied on PND 21.
F0 maternal survival was unaffected by test diet exposure. No remarkable clinical

findings were noted at the daily examinations and no test substance-related changes in
detailed clinical observations were noted at any F0 exposure level.
Maternal toxicity was expressed at 750 and 2250 ppm in the F0 generation by lower mean
body weight gains during gestation (gestation days 0-20) of 9.5% and 22.4%,
respectively, with an associated reduction in mean food consumption from the onset of
test substance exposure through gestation days 10 and 20, respectively. Mean body
weight gains and food consumption in the 750 and 2250 ppm groups were similar to the
control group throughout lactation. Mean body weights, body weight gains, and food
consumption in the 0.15, 1.5, and 75 ppm groups were unaffected by test substance
exposure throughout gestation and lactation. No additional evidence of systemic toxicity
was observed in F0 females, including liver weights, kidney weights, and microscopic
changes. There were no effects on reproductive performance.
Page 21 of 4796
With the exception of reduced mean pup body weights at exposure levels of 750 and
2250 ppm, there were no effects on litter or offspring developmental parameters.
Reductions in mean male and female pup body weight gains occurred during PND 7-14.
This resulted in lower mean male and female pup body weights during PND 14-17 in the
750 ppm group (up to 5.6% lower) and PND 11-21 in the 2250 ppm group (up to 8.3%
lower) relative to the control group. There were no test substance-related effects on
post-weaning body weight or the onset of sexual maturation as measured by the age of
attainment of vaginal opening or preputial separation.
For F1 males and females, there were no test substance-related effects on DCO, motor
activity, auditory startle, learning and memory, macroscopic examinations and
measurements, neuropathology, or brain morphometry at any dietary concentration at any
age. At the PND 11 DCO, two pups in the 750 ppm group and four pups in the 2250 ppm
group exhibited clonic movements that were recorded as convulsions and/or popcorn
seizures. These observations were not reproduced in a follow-up study (Stump, 2009;
WIL-186058) conducted under conditions designed to replicate, as closely as possible,
this original developmental neurotoxicity study through PND 11. A single dietary
concentration (2250 ppm) was used in the follow-up study, with DCO conducted on
twice the number of pups per litter (from 27 litters). The initial observations were not
considered to be test substance-related because they were not noted at any other age, and
they were not reproduced in the follow-up study. In addition, no other neurobehavioral
or neuropathological parameters were altered in any animals, including those that
exhibited clonic movements on PND 11.
In conclusion, there were no test substance-related effects observed in this study at

dietary concentrations of 75 ppm or lower (0.15 and 1.5 ppm). Reductions in mean body
weight and body weight gain were observed in dams and offspring at dietary
concentrations of 750 and 2250 ppm. There was no evidence of non-monotonic
exposure-response curves for any parameter. Therefore, the no-observed-adverse-effect
Page 22 of 4796
level (NOAEL) for systemic toxicity of BPA was 75 ppm (5.85 mg/kg/day and
13.1 mg/kg/day during gestation and lactation, respectively).
There was no evidence of developmental neurotoxicity at any dietary concentration.

Thus, the NOAEL for developmental neurotoxicity of BPA was 2250 ppm
(164 mg/kg/day and 410 mg/kg/day during gestation and lactation, respectively), the
highest dietary concentration tested. Based on the conditions of this study, there was no
evidence that BPA is a developmental neurotoxicant in rats.
Page 23 of 4796
2. INTRODUCTION
2.1. GENERAL STUDY INFORMATION
This report presents the data from A Dietary Developmental Neurotoxicity Study of
Bisphenol A in Rats. Due to software spacing constraints, the study title is presented as
Dietary Developmental Neurotoxicity Study of Bisphenol A in Rats on the report
tables. For clarification of the terminology used to differentiate the generations in the
report text, the offspring of the F0 generation were defined as the F1 litters; pups from the
F1 litters were selected to constitute the F1 generation.
The following computer protocols were used for data collection during the study:
Computer Protocol Type of Data Collected

WIL-186056 ........................................... F0 maternal and F1 litter data (including
F0 detailed clinical observations and
F1 surface righting reflex data)
WIL-186056A ........................................ F1 male (Subsets A and B) post-weaning
body weight, clinical observations,
developmental landmarks, and necropsy
data (necropsy data for animals in
Subset B only)
WIL-186056D ........................................ F1 female (Subsets A and B) post-weaning
body weight, clinical observations,
developmental landmarks, and necropsy
data (necropsy data for animals in Subset
B only)
WIL-186056S......................................... F1 Subset A detailed clinical observations,
motor activity, auditory startle response,
and PND 62 learning and memory data
WIL-186056W ....................................... F1 Subset B learning and memory data
(PND 22)
WIL-186056U ........................................ F1 Subset C necropsy and brain
weight/measurement/morphometry data
(PND 21)
WIL-186056V ........................................ F1 Subset A necropsy and brain
weight/measurement/morphometry data
(PND 72)
Page 24 of 4796
2.2. KEY STUDY DATES1

Date(s) Event(s)
1 July 2008.............................................. Animal receipt (Cohort 1; OECD
experimental starting date)
13-17 July 2008 ...................................... F0 mating period (Cohort 1)
14 July 2008 ........................................... Initiation of F0 test diet exposure (Cohort 1;
EPA experimental start date)
14 July - 29 August 2008 ....................... F0 test diet exposure (Cohort 1)
29 July 2008 ........................................... Animal receipt (Cohort 2)
6 August - 15 October 2008 ................... F1 developmental indices and behavioral
testing (Cohort 1)
10-14 August 2008 ................................. F0 mating period (Cohort 2)
11 August - 26 September 2008............. F0 test diet exposure (Cohort 2)
25-29 August 2008 ................................. F0 lactation day 21 and F1 PND 21
(Subsets C and D) necropsies (Cohort 1)
4 September - 12 November 2008 ......... F1 developmental indices and behavioral
testing (Cohort 2)
8-9 September 2008................................ F1 necropsies (Subset B - following
completion of PND 22 learning and
memory assessments - Cohort 1)
23-26 September 2008 ........................... F0 lactation day 21 and F1 PND 21
(Subsets C and D) necropsies (Cohort 2)
8-9 October 2008.................................... F1 necropsies (Subset B - following
completion of PND 22 learning and
memory assessments - Cohort 2)
15-19 October 2008................................ F1 PND 72 (Subset A) necropsies
(Cohort 1)
13-16 November 2008............................ F1 PND 72 (Subset A) necropsies
(Cohort 2)
10 September 2009................................. Experimental termination/completion date
(last F1 neuropathologic and/or
morphometric examination)
2.3. PRINCIPAL INVESTIGATOR AND TEST SITE

Test Site Principal Investigator Les Freshwater, MS
for Statistical Analysis BioSTAT Consultants, Inc.
528 W. Centre St.
Portage, MI 49024
1
Date ranges represent the first and last dates of evaluation.
Page 25 of 4796
3. STUDY DESIGNA
Acclimation period
F0 clinical observations, body weights, and food

consumption recorded at appropriate intervals
24 mated F0 females per group (1-6) offered

basal or test diets from gestation day 0
through lactation day 21
F0 detailed clinical observations performed on

gestation days 10 and 15 and lactation days 10 and 21
All F0 females allowed to deliver
Gross necropsies were performed

on F0 animals that were found
dead or failed to deliver
F1 pups potentially exposed to test substance in

utero and through nursing during lactation and via
direct consumption of the maternal test diet during
the latter portion of the pre-weaning period
F1 pups observed daily; detailed physical

examinations and body weights recorded at
appropriate intervals
F1 pups evaluated for surface righting reflex

beginning on PND 2
Necropsies performed on lactation

Litters standardized on PND 4 to
day/PND 4 for dams and pups that
eight pups of equal sex distribution
failed to meet the sex ratio criteria for
when possible. Culled pups euthanized
inclusion in the study and for pups
and discarded without examination
found dead or euthanized in extremis
on PND 4.
throughout the postnatal period
F0 females necropsied on lactation day 21; liver and

kidneys weighed and examined microscopically
A= In order to accommodate the introduction of variables that could have affected the study
outcome and to accommodate the logistics of data collection, the study consisted of
two cohorts starting approximately four weeks apart; each cohort was composed of
12 females per group.
Page 26 of 4796
STUDY DESIGN (CONTINUED) A
Subset C
One pup/sex/litter
Subset D
selected for in situ
Nonselected pups
perfusion; brain
necropsied on
weights, and brain
PND 21
measurements on
PND 21
Neuropathological and
morphometric
evaluations conducted
for 10 pups/sex/group
Subset B
Subset A One pup/sex/litter selected
One pup/sex/litter selected for for learning and memory
post-weaning developmental landmarks
evaluations beginning on
beginning on PND 25 or 35; startle PND 22
response evaluations on PND 20 and 60;
motor activity evaluations on PND 13, 17,
21, and 61; detailed clinical observations Gross necropsy performed
on PND 4, 11, 21, 35, 45, and 60; learning on all F1 Subset B rats
and memory evaluation beginning on following completion of
PND 62 learning and memory
evaluations
All animals selected for in situ perfusion;

brain weights, and measurements
on PND 72
Neuropathological and morphometric

evaluations conducted for
10 rats/sex/group
A= In order to accommodate the introduction of variables that could have affected the study
outcome and to accommodate the logistics of data collection, the study consisted of
two cohorts starting approximately four weeks apart; each cohort was composed of
12 females per group.
Page 27 of 4796
4. EXPERIMENTAL PROCEDURES - MATERIALS AND METHODS

4.1. TEST SUBSTANCES AND VEHICLE
4.1.1. TEST SUBSTANCE IDENTIFICATION
The test substance, bisphenol A (BPA), was provided by Acros Organics NV, Fair Lawn,
NJ and was received from Research Triangle Institute, Research Triangle Park, NC, on
5 December 2007, as follows:
Physical
Identification Description
Bisphenol A White granular solid

Lot no. B0070138
Exp. date: None*
CAS no. 80-05-07
[WIL log no. 7777A]
* = Because the purity ranged from 99.1% to 99.76% over an approximate

11-year period, the test substance was expected to be stable indefinitely and
an expiration date was not assigned.
Documentation regarding the purity and stability of the test substance is on file with the
Sponsor and WIL Research Laboratories, LLC. The Certificates of Analysis for the test
substance prepared prior to and following the experimental phase of the study were
provided by the Sponsor and are presented in Appendix B. The purity of the test
substance ranged from 99.59% to 99.62%. The test substance was stored at room
temperature in a desiccator, protected from light, and was considered stable under these
conditions. A reserve sample (1.0 g) of the test substance was collected and is stored (in
a desiccator and protected from light) in the Archives of WIL Research Laboratories,
LLC.
4.1.2. CARRIER IDENTIFICATION

PMI Nutrition International, LLC, Certified Rodent LabDiet 5002 (meal) was used in
the preparation of the control and test diets. A single lot (no. JUN03082C) was used for
the entire study, with the following exception. During the first day of the mating period
Page 28 of 4796
for Cohort 1 (13-14 July 2008), males and females were offered the basal diet from lot
no. APR09082C. This one day of exposure to the different lot did not negatively impact
the quality or integrity of the data or the outcome of the study.
4.1.3. PREPARATION
For the control group, an appropriate volume of acetone (lot nos. [exp. dates]: 076771
[21 February 2010], 076783 [28 February 2010], and 076784 [3 March 2010]; received
from Fisher Scientific, Co. LLC, Florence, KY) was added to a glass jar. For control
group diets prepared on 4 August 2008 and thereafter, basal diet and acetone were mixed
for approximately five minutes in a Hobart mixer and disposed prior to mixing the diet
for exposure to the control group to ensure the absence of any test substance in the mixer;
a Hobart mixer and paddle were dedicated for preparation of control group diets only.
Following cleaning of the mixer, approximately 10 kilograms of PMI Nutrition
International, LLC, Certified Rodent LabDiet 5002 (meal) was placed in the Hobart
mixer, and 400 mL of acetone was added (the approximate amount added for the
preparation of the diets for Groups 2-6). The basal diet pre-mix was mixed for
approximately five minutes and the remaining 10 kilograms of basal diet (initially
weighed in a metal container) was added to the mixer and mixed for approximately
10 minutes. The prepared diet for the control group was stored in metal containers
dedicated for use for the control group diet only.
For preparation of the test diets for Groups 2 and 3, a test substance stock solution
(0.1 mg/mL) was prepared as follows. An appropriate amount of the test substance was
added to a tared weighing vessel. Approximately 50% of the acetone and the appropriate
amount of test substance were added to a volumetric flask. The flask was swirled and
acetone was added to bring the mixture to the calibration mark. This stock solution was
used to prepare the Group 2 and Group 3 stock solutions. For the Group 2 and 3 stock
solutions, the appropriate volume of the 0.1 mg/mL stock solution was added to glass
jars. The appropriate amount of acetone was added to each jar, and the contents were
mixed using a magnetic stirrer until uniform.
Page 29 of 4796
Test diets for Groups 2 and 3 were prepared as follows. The appropriate amount of the
appropriate stock solution was added to a reagent sprayer. Approximately 10 kilograms
of basal diet was weighed into a metal container and added to a Hobart mixer. Using the
sprayer, approximately one-half of the desired volume of stock solution was sprayed onto
the diet. The diet was mixed for approximately two minutes and the remaining
10 kilograms of basal diet (initially weighed in a metal container) was added to the mixer
and sprayed with the remaining stock solution. The diet was mixed for approximately
15 minutes. The volume of stock solution added to the diet for Groups 2 and 3 was
approximately 15% greater than the required amount to account for the loss of stock
solution during the spraying process. Following preparation of the test diet for Group 3,
the Hobart mixer was washed with soap and water and rinsed twice with adequate
volumes of acetone. Following washing, approximately one kilogram of basal diet and
200 mL of acetone were mixed for approximately two minutes in the mixer; this diet was
then disposed.
Test diets for Groups 4-6 were prepared in a room separate from the room used to prepare
the test diets for Groups 1-3, as follows. The appropriate amount of test substance was
added to a tared glass jar. The appropriate volume of acetone was added to the glass jar,
and the contents were swirled to dissolve the test substance. The dissolved test substance
was transferred into a Hobart mixer with approximately five kilograms of diet. The
formulation was then mixed for approximately 10 minutes. The resultant formulation
was termed pre-mix and was at an approximately four-fold higher concentration than the
desired final concentration. The appropriate amount of additional diet (approximately
15 kilograms) to achieve the desired concentration was weighed in a metal container and
placed in a V-blender (i.e. twin shell blender), and the pre-mix was then added to the
blender. The diet was blended for approximately 15 minutes (an intensifier bar was used
during the first and last 5 minutes).
The control and test diets were prepared approximately bi-weekly and placed in stainless
steel storage containers. Approximately half of each formulation was stored at room
Page 30 of 4796
temperature for use during the first week of exposure, and the remaining half of each
formulation was stored frozen for use during the second week of exposure.
4.1.4. SAMPLING AND ANALYSIS

Stability of the test substance in the diet at a concentration range of 10 ppb to 7500 ppm
following up to 15 days of room temperature and frozen storage was established in a
previous study (Bodle, 2009; WIL-186057). Therefore, stability analyses were not
conducted in this study.
Prior to the initiation of test substance exposure, duplicate samples (approximately 100 g)
were collected from the top, middle, and bottom of each test diet formulation prepared for
the first week of exposure and analyzed for homogeneity; samples were also collected
from the middle of the control diet. For concentration analysis, duplicate samples
(approximately 100 g) were collected from the middle of the control and test diets
prepared for the remainder of the study. One set of samples from each collection was
analyzed and the remaining set of samples was stored frozen (approximately -20C). All
analyses were performed by the Analytical Chemistry Department, WIL Research
Laboratories, LLC. The methodology and results of these analyses are presented in
Appendix C and are summarized in Section 6.1.
4.2. TEST SYSTEM

Sexually mature, virgin female Sprague Dawley Crl:CD(SD) rats, hereafter referred to as
Crl:CD(SD) rats, from Charles River Laboratories, Inc., Raleigh, NC, were used as the
test system on this study.
The animal model selected, the Crl:CD(SD) rat, is recognized by international regulatory
agencies as appropriate for developmental neurotoxicity studies. WIL Research
Laboratories, LLC, has reproductive and neurotoxicity historical control data for the
Crl:CD(SD) rat. As specified in the guidelines, positive control data, using reference
chemicals to establish the reliability and sensitivity of the test methods at the appropriate
Page 31 of 4796
offspring ages used for neurotoxicity endpoints, were developed by WIL Research
Laboratories, LLC and are included in Appendix L.
4.3. ORGANIZATION OF TEST GROUPS, EXPOSURE LEVELS, AND

TREATMENT REGIMEN
The control and test diets were offered ad libitum to the F0 females daily from gestation
day 0 to lactation day 21. The test substance was administered as a constant
concentration (ppm) in the diet. The F0 maternal animals were assigned to study groups
as follows:
Target
Group Exposure Level Exposure Level Number of Femalesa
Number Test substance (ppm) (mg/kg/day) Cohort 1 Cohort 2
1 Basal Diet 0 0 12 12
2 Bisphenol A 0.15 0.01 12 12
3 Bisphenol A 1.5 0.1 12 12
4 Bisphenol A 75 5 12 12
5 Bisphenol A 750 50 12 12
6 Bisphenol A 2250 150 12 12
a
= In order to accommodate the logistics of data collection, the study consisted of two cohorts
starting approximately four weeks apart.
Exposure levels were selected to provide doses that spanned the range from low doses
used in some published studies reporting developmental neurotoxicity (CERHR, 2007) to
a high dose that was anticipated to result in systemic toxicity in the pregnant rat. This
high dose was selected based on the results of a previous range-finding study in which
BPA was offered on a continuous basis in the diet to rats at exposure levels of 250, 750,
2500, and 7500 ppm (Stump, 2009; WIL-186055). In the range-finding study, an
exposure level of 7500 ppm exceeded the maximum tolerated dose based on maternal
body weight losses and lower body weight gain and food consumption resulting in early
termination of the group during gestation. Mean maternal body weight losses and/or
lower mean body weight gains and food consumption were also observed at exposure
levels of 750 and 2500 ppm. Slightly lower pup birth weights, pup weight gains, and
postnatal survival were noted at 2500 ppm. Based on these results and information from
Page 32 of 4796
other studies with BPA, exposure levels of 0.15, 1.5, 75, 750, and 2250 ppm were
selected for the current study.
The F1 animals in the present study were potentially exposed to the test substance in
utero, as well as via the milk while nursing and via direct consumption of the diet during
the latter portion of the lactation period. To maximize exposure, the dietary
concentration was not adjusted to provide a consistent dose of BPA (mg/kg/day) during
lactation, although it is well documented that an increased food consumption (to support
milk production) would result in a higher dose to the dams during this period.
The selected route of administration was oral (dietary) because this is a potential route of
human exposure. The number of animals selected for this study was the minimum
required to meet the goals of the study and fulfulled the U.S. EPA OPPTS and OECD
testing guidelines.
4.4. F0 MATERNAL GENERATION

4.4.1. ANIMAL RECEIPT AND ACCLIMATION
One hundred eighty sexually mature female Crl:CD(SD) rats were received from Charles
River Laboratories, Inc., Raleigh, NC. Ninety females were received on 1 July 2008
(Cohort 1) and 90 additional females were received on 29 July 2008 (Cohort 2). The
animals were approximately 70 days old upon receipt. Each animal was examined by a
qualified technician on the day of receipt and weighed the following day. Each rat was
uniquely identified by a Monel metal ear tag displaying the animal number and housed
for 13 days for acclimation purposes. Individual cage cards that displayed the animal
number, group number, study number, dose level, and sex of the animal were also affixed
to each cage. During the acclimation period, the rats were observed twice daily for
general changes in appearance and behavior. Body weights were recorded prior to the
initiation of mating.
Page 33 of 4796
4.4.2. ANIMAL HOUSING

Upon arrival and until pairing, all animals were individually housed in clean, stainless
steel wire-mesh cages suspended above cage-board which was changed at least three
times per week. The animals from the two cohorts were housed in separate
environmentally controlled rooms. The animals were paired for mating in the home cage
of the resident male. Following positive evidence of mating, the females were
individually housed in stainless steel wire-mesh cages until gestation day 18. Thereafter,
females were housed in polyphenylsulfone RaTEMP thermoplastic rat cages (Allentown
Inc., Allentown, NJ) with nesting material, ground corncob bedding (Bed-O'Cobs; The
Andersons, Cob Products Division, Maumee, OH). The nesting material, used in all
developmental neurotoxicity studies at WIL Research Laboratories, LLC, including
positive control studies, is periodically analyzed by the manufacturer for contaminants.
Analyses of the nesting material are provided by the manufacturer and are presented in
Appendix D. No contaminants were present in the bedding at concentrations sufficient to
interfere with the outcome of the study. The results of these analyses are maintained at
WIL Research Laboratories, LLC. The females were housed in these cages through
lactation day 21, the scheduled day of necropsy. Pups that continued on study following
weaning on PND 21 were housed by litter in the polyphenylsulfone RaTEMP
thermoplastic rat cages with nesting material until PND 28. On PND 28, surviving
offspring were housed individually in suspended wire-mesh, stainless steel cages until
euthanasia. Females that did not deliver were necropsied on post-mating day 25.
Animals were housed in accordance with the Guide for the Care and Use of Laboratory
Animals (National Research Council, 1996) The animal facilities at WIL Research
Laboratories, LLC, are accredited by the Association for Assessment and Accreditation
of Laboratory Animal Care International (AAALAC International).
4.4.3. DIET, DRINKING WATER, AND MAINTENANCE

The basal diet used in this study, PMI Nutrition International, LLC, Certified Rodent
LabDiet 5002 (meal), is a certified feed with appropriate analyses performed by the
manufacturer and provided to WIL Research Laboratories, LLC. A single feed lot
Page 34 of 4796
(no. JUN03082C) was used during the study and was documented in the study records,
with the following exception. During the first day of the mating period for Cohort 1
(13-14 July 2008), males and females were offered the basal diet from lot
no. APR09082C. The phytoestrogen content of feed lot no. JUN03082C (total
isoflavones of 312 ppm aglycone units) is presented in Appendix E; the phytoestrogen
content of feed lot no. APR09082C was not evaluated because the single day of exposure
to this feed lot during the mating period was not expected to have an impact on the
outcome of the study. Feeders were changed and sanitized at least once per week.
Municipal water supplying the facility is sampled for contaminants according to standard
operating procedures. The results of the diet and water analyses are maintained at WIL
Research Laboratories, LLC, and are presented in Appendix E. No contaminants were
present in animal feed or water at concentrations sufficient to interfere with the objectives
of this study. Reverse osmosis-purified (on-site) drinking water, delivered by an
automatic watering system was provided ad libitum throughout the acclimation period
and during the study; the lixits were checked daily for proper functioning. The basal diet
was provided ad libitum to all groups throughout the acclimation period, to Groups 2-6
through the day of evidence of mating, and to the control group (Group 1) throughout the
study. Beginning on gestation day 0, the appropriate test diet was offered to Groups 2-6
through lactation day/PND 21. Following weaning on PND 21 and throughout the
remainder of the study, the basal diet was provided to the F1 animals in all groups.
4.4.4. ENVIRONMENTAL CONDITIONS

All rats were housed throughout the acclimation period and during the study in one of
two environmentally controlled rooms. The room temperature and humidity controls
were set to maintain average daily environmental conditions of 71F 5F (22C 3C)
temperature and 50% 20% relative humidity. Room temperature and relative humidity
were controlled and monitored using the Metasys DDC Electronic Environmental
control system. These data were recorded approximately hourly and are summarized in
Appendix F. Actual mean daily temperature ranged from 70.2F to 72.2F (21.2C to
Page 35 of 4796
22.3C) and mean daily relative humidity ranged from 37.5% to 54.8% for animals in
Cohort 1 (B Room 47). For animals in Cohort 2 (B Room 42), actual mean daily
temperature ranged from 70.2F to 72.7F (21.2C to 22.6C) and mean daily relative
humidity ranged from 40.0% to 50.8%. Fluorescent lighting controlled by light timers
were calibrated to provide a 12-hour light (0600 hours to 1800 hours)/12-hour dark
photoperiod. Air handling units were set to provide a minimum of 10 fresh air changes
per hour.
4.4.5. ASSIGNMENT OF ANIMALS TO TREATMENT GROUPS AND BREEDING

PROCEDURES
At the conclusion of the respective acclimation periods, all available females were
weighed and examined in detail for physical abnormalities. At the discretion of the Study
Director, each animal judged to be in good health and meeting acceptable body weight
(minimum of 220 g) requirements at the time of cohabitation was placed in a suspended
wire-mesh cage with a resident male from the same strain and source for mating.
Resident males were untreated, sexually mature rats utilized exclusively for mating and
were paired only once for breeding. These rats were maintained under similar laboratory
conditions as the females. A breeding record containing the male and female
identification numbers and the date of cohabitation was prepared. The selected females
were approximately 12 weeks old when paired for mating.
Positive evidence of mating was confirmed by the presence of a vaginal copulatory plug
or the presence of sperm in a vaginal lavage. Each mating pair was examined daily. The
day on which evidence of mating was identified was termed gestation day 0, and the
animals were separated.
The experimental design consisted of five test substance-treated groups and one control
group, composed of 24 rats each consisting of two cohorts starting approximately four
weeks apart; each cohort was composed of 12 females per group. On each gestation
day 0, the bred females were assigned to groups using a WIL Toxicology Data
Management System (WTDMS) computer program which randomized the animals
Page 36 of 4796
based on stratification of the gestation day 0 body weights in a block design. Body
weight values ranged from 231 g to 297 g on gestation day 0.
Page 37 of 4796
5. PARAMETERS EVALUATED
5.1. F0 OBSERVATIONS
5.1.1. CLINICAL OBSERVATIONS AND SURVIVAL
All rats were observed twice daily, once in the morning and once in the afternoon, for
moribundity and mortality. Individual clinical observations were recorded daily for each
F0 female from gestation day 0 until necropsy. The observations included, but were not
limited to, evaluations for changes in skin and fur, eyes, mucous membranes, respiratory
and circulatory systems, autonomic and central nervous systems, somatomotor activity,
and behavior. The absence or presence of findings was recorded for individual animals.
Females expected to deliver were also observed twice daily during the period of expected
parturition and at parturition for dystocia (prolonged labor, delayed labor, or other
difficulties).
5.1.2. DETAILED CLINICAL OBSERVATIONS

All dams in each group were observed outside of the home cage in an open field on
gestation days 10 and 15 and on lactation days 10 and 21. The following parameters
were evaluated (refer to Appendix G for a detailed description of the scoring criteria used
for each observation):
Arousal Mobility
Backing Mucous membrane/eye/skin
Bizarre/stereotypic behavior color
Convulsions/tremors Muscle tone
Ease of handling animal in hand Palpebral closure
Ease of removal from cage Piloerection
Eye prominence Pupillary response
Fur appearance Red/crusty deposits
Gait Respiratory rate/character
General body posture Salivation
Grooming Urination/defecation
Lacrimation/chromodacryorrhea
The detailed clinical observation battery utilized at WIL Research Laboratories, LLC, is
based on previously developed protocols (Gad, 1982; Haggerty, 1989; Irwin, 1968;
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Moser et al. 1988; Moser et al. 1991; ODonoghue, 1989). Testing was performed by
trained biologists without knowledge of the animals group assignment.
5.1.3. BODY WEIGHTS

Individual maternal body weights were measured on gestation days 0, 3, 7, 10, 14, 17,
and 20 and on lactation days 1, 4, 7, 11, 14, 17, and 21. Group mean body weights were
calculated for each of these days. Group mean body weight changes were calculated for
each corresponding interval of gestation and lactation and also for gestation days 0-7,
7-14, 14-20, and 0-20 and for lactation days 1-21. When body weights could not be
determined for an animal during a given interval (due to an unscheduled death or pup sex
ratio criteria not met), group mean values were calculated for that interval using the
available data.
5.1.4. FOOD CONSUMPTION AND TEST SUBSTANCE CONSUMPTION

Individual maternal food consumption was recorded on gestation days 0, 3, 7, 10, 14, 17,
and 20 and on lactation days 1, 4, 7, 11, 14, 17, and 21. Food intake was reported as
g/animal/day for the corresponding body weight change intervals. Mean test substance
consumption (mg/kg/day) for each group was determined by multiplying the
concentration of the test substance in the diet (mg/kg) by the g/kg/day food consumption
value for each interval.
When food consumption could not be determined for an animal during a given interval
(due to an unscheduled death, pup sex ratio criteria not met, weighing error, food
spillage, obvious erroneous value, etc.), group mean values were calculated for that
interval using the available data. The time periods when food consumption values were
unavailable for a given animal were designated as NA (Not Applicable) on the
individual report tables.
5.1.5. PARTURITION
All females were allowed to deliver naturally and rear their young to weaning (PND 21).
During the period of expected parturition, the females were observed twice daily for
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initiation and completion of parturition and for signs of dystocia. The day parturition was
initiated was designated lactation day 0 (dams) and PND 0 (pups). On the day parturition
completed (PND 0 or 1), pups were sexed and examined for gross malformations, and the
numbers of stillbirths and live pups were recorded. Individual gestation length was
calculated using the date delivery was first observed.
5.1.6. ANATOMIC PATHOLOGY

5.1.6.1. MACROSCOPIC EXAMINATIONS
All surviving females with viable pups on lactation day 21, that had six pups or fewer or
failed to meet the pup sex ratio criteria (lactation day 4), and that did not deliver
(post-mating day 25) were euthanized by carbon dioxide inhalation. A gross necropsy
was performed for each of these females. In addition, a gross necropsy was performed
for one female that was found dead. The gross necropsy included examination of the
external surfaces, all orifices, and the cranial, thoracic, abdominal, and pelvic cavities.
For females that delivered, the numbers of former implantation sites (the attachment site
of the placenta to the uterus) were recorded; the number of corpora lutea was also
recorded for the female found dead on lactation day 0 and for females that failed to meet
the pup sex ratio criteria. For the female that died on lactation day 0, fetuses were
examined externally, and the litter was euthanized due to the death of the dam. The
number of unaccounted-for implantation sites was calculated by subtracting the number
of pups born from the number of implantation sites observed. For females that failed to
deliver, a pregnancy status was determined by placing the uteri in 10% ammonium
sulfide solution for detection of early implantation loss (Salewski, 1964), and specific
emphasis was placed on anatomic or pathologic findings that may have interfered with
pregnancy.
Tissues with gross lesions and the liver and kidneys from all F0 females were preserved
in 10% neutral-buffered formalin. The carcass of each female was then discarded.
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5.1.6.2. ORGAN WEIGHTS

The liver and kidneys from all F0 females (except the female that was found dead) were
weighed. Absolute weights and organ to final body weight ratios were reported. Liver
and kidney weights for F0 females that failed to deliver or whose litters failed to meet pup
sex ratio criteria on PND 4 were not included in the mean group values.
5.1.6.3. MICROSCOPIC EXAMINATIONS

Microscopic evaluations were performed on the liver and kidneys from all F0 females.
After fixation, the liver and kidneys were trimmed according to standard operating
procedures of WIL Research Laboratories, LLC. Trimmed tissues were processed into
paraffin blocks, sectioned at 4 to 8 microns, mounted on glass microscope slides and
stained with hematoxylin and eosin. Microscopic examination was performed by Ann
Radovsky, DVM, PhD, DACVP, DABT, WIL Research Laboratories, LLC. The
pathology report is presented in Appendix H.
5.2. F1 LITTER PARAMETERS

5.2.1. LITTER VIABILITY AND DEATHS
Each litter was examined daily for survival, and all deaths were recorded. All pups were
individually identified by application of foot markings (tattoo) following completion of
parturition. A daily record of litter size was maintained. Intact offspring dying from
PND 0 to 4 were examined externally and necropsied using a fresh dissection technique
that included the heart and major vessels (Stuckhardt and Poppe, 1984) and the sex was
verified (if possible). The stomachs were examined for the presence of milk on PND 0
and 1. A detailed gross necropsy was performed on any pup dying or euthanized in
extremis (by intraperitoneal injection of sodium pentobarbital) after PND 4. Tissues from
all pups found dead or euthanized in extremis were saved in 10% neutral-buffered
formalin for possible histopathological examination only as deemed necessary by the
gross findings. The carcass of each pup was then discarded.
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5.2.2. LITTER REDUCTION

To reduce variability among the litters, eight pups/litter, four/sex when possible, were
randomly selected on PND 4. Culled pups were weighed, euthanized by intraperitoneal
injection of sodium pentobarbital on PND 4 and discarded without examination. If a
litter consisted of six pups or fewer or did not meet the sex ratio criteria (at least
three/sex) for inclusion in the study, the litter was not used for neurobehavioral or
neuropathological evaluation and the pups were necropsied on PND 4. The carcass of
each pup was then discarded.
5.2.3. CLINICAL OBSERVATIONS

Litters were examined daily for survival and any adverse changes in appearance or
behavior. Each pup received a detailed physical examination on PND 4, 11, and 21 and
at weekly intervals thereafter until necropsy. Clinical observations for appearance,
behavior and overt signs of toxicity were recorded on the day observed. The
observations included, but were not limited to, evaluations for changes in skin and fur,
eyes, mucous membranes, respiratory and circulatory systems, autonomic and central
nervous systems, somatomotor activity, and behavior. Any abnormalities in nursing
behavior were recorded.
5.2.4. BODY WEIGHTS

Pups were individually weighed on PND 1, 4, 7, 11, 14, 17, 21, and at weekly intervals
thereafter until necropsy and whenever they were removed from their cages for
behavioral testing. Mean pup weights were presented by sex for each litter and by group,
with the following exceptions. Offspring weights that were recorded when the animals
were removed from their cages for behavioral testing are maintained in the study records
and are not presented in this report. In addition, when body weights could not be
recorded for a given interval (due to unscheduled death, euthanized due to pup sex ratio
criteria not met or death of dam, weighing error, etc.) group values were calculated for
that interval using the available data. The time periods when body weight values were
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unavailable for a given animal were designated as NA (Not Applicable) on the

individual report tables.
5.2.5. SEX DETERMINATION

Pups were individually sexed on PND 0 (when possible) or 1, 4, 11, and 21.
5.2.6. CALCULATION OF LITTER PARAMETERS

Litter parameters were defined as follows:
Total no. of viable pups PND 0

Mean Live Litter Size =
No. of litters with viable pups PND 0
Postnatal Survival Between Sum of (Viable pups per litter on PND 0

Birth and PND 0 or PND 4 = or PND 4/No. of pups born per litter) x 100
(% Per Litter) No. of litters/group
Sum of (Viable pups per litter

Postnatal Survival for All at end of interval N/Viable pups
x 100
Other Intervals (% Per Litter) = per litter at start of interval N)
No. of litters/group
Where N = PND 0-1, 1-4 (Pre-Selection), 4 (Post-Selection)-7,

7-14, 14-21, or 4 (Post-Selection)-21
5.2.7. WEANING AND SELECTION

Each dam and litter remained together until weaning on lactation day 21. Following
culling on PND 4, a subset (Subset A) consisting of one pup/sex/litter was assigned to
detailed clinical observations on PND 4, 11, 21, 35, 45, and 60, auditory startle response
(PND 20 and 60), motor activity (PND 13, 17, 21, and 61), and learning and memory
(PND 62). These same animals were selected for brain weight evaluations on PND 72; of
these, one pup/litter for a total of 10 animals/sex/group was selected for neuropathological
and morphometric evaluations on PND 72. A second subset (Subset B) consisting of
one pup/sex/litter was selected for learning and memory (PND 22). A third subset
(Subset C) consisting of one pup/sex/litter was selected for brain weight evaluations on
PND 21; of these, one pup/litter for a total of 10 animals/sex/group was selected for
neuropathological and morphometric evaluations on PND 21. Indicators of physical
development (balanopreputial separation and vaginal patency) were evaluated for all
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F1 animals in Subset A. All F1 animals not selected for behavioral evaluations (Subset D)
were euthanized and necropsied on PND 21. F1 animals selected for learning and memory
assessment on PND 22 (Subset B) were necropsied following completion of that
assessment.
The following table summarizes the allocation of offspring for behavioral tests, brain
weights, and neuropathological evaluation.
No. Selected (Subset) Age Evaluation

One pup/sex/litter (C) PND 21 Brain weights, Neuropathological
assessment, Morphometry*
One pup/sex/litter (A)** PND 4, 11, 21, Detailed Clinical Observations+
35, 45, and 60
One pup/sex/litter (A)** PND 20 and 60 Auditory startle
One pup/sex/litter (A)** PND 13, 17, 21, Motor Activity+
and 61
One pup/sex/litter (B) PND 22 Learning and Memory***
One pup/sex/litter (A)** PND 62 Learning and Memory***
One pup/sex/litter (A)** PND 72 Brain weights, Neuropathological
assessment, Morphometry*
* - Neuropathological and morphometric evaluations were conducted on
10 pups/sex/group (one pup per litter).
** - The same pup subset was used for detailed clinical observations,
auditory startle, motor activity, and learning and memory assessment
at 62 days of age. Except as directed for learning and memory, the
same pups were evaluated at multiple time points.
*** - Different pups were evaluated on PND 22 and 62.
+ - For tests that occur on the day of weaning (PND 21), pups were
removed from the litter prior to removing the dam.
Selected pups retained the dam number and tattoo mark (e.g., 99999-01). Each selected
pup was uniquely identified by a metal ear tag displaying the identification number
following weaning.
5.2.8. DEVELOPMENTAL LANDMARKS, SENSORY FUNCTION, AND

NEUROBEHAVIORAL TESTING
The various investigations described herein were used to assess the maturation and
behavioral development of the selected F1 pups. Cumulative litter values include pups
Page 44 of 4796
that tested positive for the event but were found dead prior to the end of the testing
period.
5.2.8.1. SURFACE RIGHTING RESPONSE

Each pup was evaluated for attainment of surface righting response beginning on PND 2.
Each pup was placed in a supine position and allotted two seconds to return to an upright
position. Failure to return to an upright position in the allotted time was considered a
negative response. Pups were evaluated daily until demonstration of a positive surface
righting reflex or until the pup was found dead, missing, or selected for culling (i.e. for
pups that did not have a positive response by PND 4). Litters that failed to meet the pup
sex ratio criteria on PND 4 were excluded from statistical analysis due to the limited
number of pups (zero to two pups/litter) having a positive surface righting response in
these litters prior to euthanasia.
5.2.8.2. BALANOPREPUTIAL SEPARATION (SUBSET A)

Each male pup was observed for balanopreputial separation beginning on PND 35
(Korenbrot et al., 1977). The day on which balanopreputial separation was first observed
was recorded for each pup. Examination of the pups continued daily until
balanopreputial separation was present. Individual body weights were recorded on the
day of attainment of this landmark.
5.2.8.3. VAGINAL PATENCY (SUBSET A)

Each female pup was observed for vaginal perforation beginning on PND 25 (Adams et
al., 1985). The day on which the vaginal lumen was first observed to open was recorded
for each pup. Examination of the females was continued daily until vaginal patency was
present. Individual body weights were recorded on the day of attainment of this
landmark.
5.2.8.4. DETAILED CLINICAL OBSERVATIONS (SUBSET A)

One pup/sex/litter was observed outside of the home cage in an open field for a duration
of two minutes on PND 4, 11, 21, 35, 45, and 60; all pup detailed clinical observations
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were conducted by trained biologists without knowledge of the animals group

assignment. The same animals were examined at each interval, with the following
exception. Any animal found dead between PND 4 and 13 was replaced with a littermate
of the same sex, if available. The following parameters were evaluated:
Arousal Lacrimation/chromodacryorrhea
Backinga Mobilitya
Bizarre/stereotypic behavior Mucous membrane and skin
Convulsions/tremors color
Ease of handling animal in hand Muscle tone
Ease of removal from cage Palpebral closurea,b
Eye colora,b Piloerectiona,b
Eye prominencea,b Pupillary responsea,b
Fur appearancea,b Red/crusty deposits
Gaita Respiratory rate/character
General body posture Salivation
Groominga,b Urination/defecation
a
= Parameters were not assessed on PND 4 due to stage of development.
b
= Parameters were not assessed on PND 11 due to stage of development.
5.2.8.5. AUDITORY STARTLE RESPONSE (SUBSET A)

An auditory startle response test was performed on one rat/sex/litter on PND 20 and 60
(following the detailed clinical observations) using the Kinder Scientific StartleMonitor
System (Kinder Scientific, LLC, Poway, CA). The same animals were tested at each
interval. Each compact cabinet was composed of high-quality laminate and
medium-density fiberboard, and measured 10.9 x 14.0 x 19.5 inches. Each cabinet was
equipped with an internal light, fan, viewing lens, and a white-noise generation system.
The animal was placed in a rectangular enclosure of appropriate size, which was then
placed into the isolation cabinet. Each enclosure was equipped with a motion sensor.
Auditory startle response testing was performed in a room equipped with a white-noise
generation system set to operate at 70 10 decibels [dB(A)]. Each test session consisted
of a five-minute acclimation period with a 65 5-dB(A) broadband background white
noise. The startle stimulus for each trial was a 115 5-dB(A) mixed-frequency noise
burst stimulus, approximately 20 milliseconds (ms) in duration. Responses were
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recorded during the first 100 ms following the onset of the startle stimulus for each trial.
Each test session consisted of 50 trials, with an eight-second intertrial interval. Startle
response data were analyzed in five blocks of 10 trials each. Startle response
measurements obtained were maximum response amplitude (MAX) in Newtons (N) and
latency to MAX (TMAX) in milliseconds (ms). TMAX was used as a reference to verify
analysis of the primary startle response and was not statistically analyzed.
5.2.8.6. MOTOR ACTIVITY (SUBSET A)

Motor activity testing was performed in a room equipped with a white-noise generation
system set to operate at 70 10 decibels [dB(A)]. Motor activity was assessed for
one rat/sex/litter on PND 13, 17, 21 (following the detailed clinical observations), and 61.
The same animals were tested at each interval. Motor activity was measured
automatically using the Kinder Scientific Motor Monitor System (Kinder Scientific, LLC,
Poway, CA). This personal computer-controlled system utilizes a series of infrared
photobeams surrounding an amber, plastic rectangular cage to quantify an animals motor
activity. Four-sided black plastic enclosures were used to surround the transparent plastic
boxes and decrease the potential for distraction from extraneous environmental stimuli or
activity by biologists or adjacent animals. The black enclosures rested on top of the
photobeam frame and did not interfere with the path of the beams. Each animal was
tested separately. Data were collected in five-minute epochs (print intervals) and the test
session duration was 60 minutes. These data were compiled as six 10-minute
subintervals for tabulation.
Data for total motor activity were tabulated. Total motor activity was defined as a
combination of gross and fine (interruption of a single photobeam) motor movement.
5.2.8.7. BIEL MAZE SWIMMING TRIALS (SUBSETS A AND B)

Beginning on PND 22 and PND 62, swimming ability and learning and memory were
assessed for one rat/sex/litter (assigned to Subsets B and A, respectively) using a
water-filled eight-unit T-maze (Biel, 1940). Animals were placed in the maze and were
required to traverse the maze and escape by locating a submerged platform. For the
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learning and memory phases, the time required to traverse the maze and the numbers of
errors for all trials were recorded. An error was defined as any instance when an animal
deviated from the correct channel with all four feet. The first testing interval was
initiated for each animal on PND 22 (Subset B); the second testing interval was initiated
for each animal on PND 62 (Subset A). Animals tested on PND 22 were not used for the
second testing interval.
Each testing interval consisted of three phases that were conducted over
seven consecutive days. Phase 1 was an evaluation of swimming ability and motivation
to escape from the maze, and was performed on day 1 of the Biel maze procedure. For
this evaluation, animals were placed in a straight channel opposite the escape platform,
and the time required for each animal to escape was recorded. Each animal was allowed
four trials to evaluate swimming ability and motivation. For each trial, animals were
allowed two minutes to complete the trial. At the end of each trial, the animal was
immediately placed at the starting position for another trial until all four trials were
complete.
Phase 2 of the Biel maze procedure evaluated sequential learning. This evaluation was
conducted on days 2-6 of the Biel maze procedure. Animals were allowed two trials per
day for two days to solve the maze in path A. Animals were then allowed two trials per
day for three consecutive days to solve the maze in path B (reverse of path A).
Phase 3 of the Biel maze procedure probed the animal for its memory to solve the maze
when challenged in path A. This evaluation was conducted on day 7 of the Biel maze
procedure. Each animal was allowed two trials to solve the maze in path A.
For each trial in Phases 2 and 3, animals were allowed three minutes to solve the maze.
If an animal did not escape the maze within the allotted three minutes, the animal was
placed on the escape platform for approximately 20 seconds, then removed from the
maze. The minimum intertrial interval for these phases was one hour.
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Biel maze data were evaluated as the numbers of errors committed during Phases 2 and 3
(i.e., sequential learning and memory). Time to escape was recorded to verify that the
animals were removed within the specified time (two minutes for Phase 1 and three
minutes for Phases 2 and 3). The time to escape data were not statistically analyzed and
are presented in Appendix A.
A diagram of Path A and Bath B of the Biel water maze is shown below:
5.2.9. MACROSCOPIC AND MICROSCOPIC EXAMINATIONS

5.2.9.1. OFFSPRING NOT SELECTED FOR BEHAVIORAL EVALUATIONS
(SUBSET D)
On PND 21, all F1 animals not selected for behavioral evaluations (Subset D) were
euthanized by carbon dioxide inhalation and subjected to gross pathology examinations.
The necropsy included examination of the external surface, all orifices, and the cranial,
thoracic, abdominal, and pelvic cavities, including viscera. Tissues were retained in
10% neutral-buffered formalin only as deemed necessary by the gross findings. The
carcass of each animal was then discarded.
5.2.9.2. OFFSPRING EUTHANIZED FOLLOWING COMPLETION OF THE

PND 22 LEARNING AND MEMORY ASSESSMENTS (SUBSET B)
Offspring scheduled for euthanasia after completion of the learning and memory
evaluations initiated on PND 22 (Subset B) were euthanized by carbon dioxide inhalation
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and subjected to a gross pathology examination. The necropsy included examination of

the external surface, all orifices, and the cranial, thoracic, abdominal, and pelvic cavities,
including viscera. Organ and tissue samples were preserved in 10% neutral-buffered
formalin as deemed necessary by the gross findings. The carcass of each animal was then
discarded.
5.2.9.3. NEUROPATHOLOGY (SUBSETS A AND C)

5.2.9.3.1. MACROSCOPIC EXAMINATION
On PND 21, one pup/sex/litter (Subset C) was macroscopically examined for
neuropathology. At the termination of the study (PND 72), one pup/sex/litter (Subset A)
was also macroscopically examined for neuropathology. All animals were anesthetized
by an intraperitoneal injection of sodium pentobarbital and perfused in situ with fixative
(4% paraformaldehyde/1.4% glutaraldehyde) as described in WIL standard operating
procedures. On PND 21 and 72, brains from all animals were retained for microscopic
examination. At study termination (PND 72), the central and peripheral nervous system
and tissues were dissected and preserved for microscopic examination. Following at least
36 hours in fixative, the whole brains were removed (including olfactory bulbs), weighed,
and the dimensions (length [excluding olfactory bulbs] and width) were recorded for all
Subset A and C animals. Any abnormal coloration or lesions of the external brain and
spinal cord were recorded.
5.2.9.3.2. MICROSCOPIC EXAMINATION

Brains from pups perfused on PND 21 and 72 were prepared for a qualitative
histopathological examination by embedding in paraffin, sectioning, and staining with
hematoxylin and eosin. Brains from pups in all groups (one pup/sex/litter at each age)
were processed and embedded; 10 pups/sex/group at each age (no more than
one pup/litter at each age) and any additional pups that showed potential exposure-related
effects on neurobehavioral observations or measurements (which were any pups, not
otherwise selected, that had exhibited clonic movements on PND 11) were evaluated.
Sections from all major brain regions (including olfactory bulbs, cerebral cortex,
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hippocampus, basal ganglia, thalamus, hypothalamus, midbrain, cerebellum, pons, and

medulla oblongata) were examined from 10 rats/sex/group (no more than one pup/litter)
that met the criteria for measurement; the two cohorts were as equally represented as
possible. In addition to the qualitative histopathological evaluation, a simple
morphometric analysis, as described in Section 5.2.9.3.3., was performed on the
10 pups/sex/group at each age. Specific measurements taken were determined by the
pathologist, but included at least two measurements from the neocortical, hippocampal,
and cerebellar areas.
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Nervous system tissues from the offspring perfused in situ at study termination (PND 72,
Subset A) were processed for neuropathological evaluation. The following tissues were
microscopically examined:
Brain - olfactory bulbs, cerebral cortex, hippocampus, basal ganglia, thalamus,

hypothalamus, midbrain, cerebellum, pons, and medulla oblongata
Cervical dorsal root fibers at C3 - C7*
Cervical dorsal root ganglion at C3 - C7*
Cervical ventral root fibers at C3 - C7*
Eyes with retinaa
Lumbar dorsal root fibers at T13 - L4*
Lumbar dorsal root ganglion at T13 - L4*
Lumbar ventral root fibers at T13 - L4*
Optic nervesa
Peroneal nerves (2)+
Sciatic nerves (2)+
Skeletal muscle (gastrocnemius)
Spinal cord - at cervical swellings C3 - C7 and at lumbar swellings T13 - L4**
Sural nerves (2)+
Tibial nerves (2)+
Trigeminal ganglion/nervesa
a
= Both processed and evaluated microscopically. Note that the optic tract in
the brain was also evaluated. Lesions in the optic nerve would be
associated with degeneration in the optic tract of the brain.
*
= Four to six tissues were collected at necropsy; two tissues were evaluated
microscopically
+ = One processed for microscopic examination
(2) = Indicates that two sections (one cross and one longitudinal) of the tissue
were evaluated from the right hind leg. The tissues from the left hind leg
were collected and preserved for possible future evaluation.
** = One cross and one longitudinal section
In addition to the tissues listed above, the lumbar spinal nerves associated with the
lumbar root fibers and ganglia, and the cervical spinal nerves associated with the cervical
root fibers and ganglia were examined but were tabulated only if there was an
abnormality present.
The central nervous system tissues were embedded in paraffin, and the peripheral
nervous system tissues were embedded in glycol methacrylate. Tissues were prepared for
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histopathological evaluation by sectioning and staining with hematoxylin and eosin. The
histopathologic examination included a simple morphometric analysis as described in
Section 5.2.9.3.3. Missing tissues were identified as not found at necropsy, lost at
necropsy, lost during the processing, or other designations as appropriate. Tissues may
appear on the report tables as not examined due to the tissue not being in the plane of
section, not present at trimming, etc. Neuropathology examinations of tissues from
PND 21 and PND 72 were performed by Ann Radovsky, DVM, PhD, DACVP, DABT,
WIL Research Laboratories, LLC. The pathology report is presented in Appendix H. A
peer review was performed by Robert H. Garman, DVM, Consultants in Veterinary
Pathology, Inc, Murrysville, PA. The peer review consisted of examination of brain
morphometry measurements from all PND 21 and 72 animals, microscopic evaluation of
the brains from at least 50% of the selected PND 21 and 72 animals (including those
animals euthanized on PND 72 that exhibited clonic movements on PND 11), and the
eyes with retina, optic nerves, trigeminal ganglia nerves, skeletal muscle, spinal cords,
and peripheral nerves from 25% of the selected PND 72 rats. The peer review statement
is presented in Appendix I.
5.2.9.3.3. MORPHOMETRIC ANALYSIS

Quantitative examinations of the brains from the selected PND 21 and PND 72 offspring
were conducted using the Pax-It (MIS, Inc., Franklin Park, IL) image-capturing
computer system and software (version 4.0 or later), and included the following.
Specific levels analyzed, designated as Levels 1, 3, and 5, were defined as follows.

Level 1 was a coronal section of rostral cerebrum, including caudoputamen, Level 3 was
a coronal section of mid-cerebrum (cerebral cortex, hippocampal formation, thalamus,
etc.) and Level 5 was a mid-saggital section of cerebellum and medulla oblongata. Levels
1, 3 and 5 corresponded to Plates 11, 33, and 79, respectively, in Paxinos and Watson
(1998). Measurements on Levels 1 and 3 were bilateral and were averaged for each
animal. Measurements on Level 5 were not paired since the other half of these tissues
were sectioned transversely to enable visualization of cerebellar nuclei.
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Measurements were made on homologous sections to ensure that the dimensions of the
regions were comparable. In some cases, there was deformation or irregularity of the
desired region. As a result, morphometric analysis could not be made for some regions in
a few animals and are presented as NA (Not Applicable) on the individual data tables.
5.3. STATISTICAL METHODS

All statistical tests were performed using appropriate computing devices or programs and
were in accordance with the published literature (Holson et al., 2007). The litter was
used as the experimental unit, where applicable. The data for Cohorts 1 and 2 were
combined for all statistical analyses. Analyses were conducted for Type I error, using
two-tailed tests (except as noted otherwise) for minimum significance levels of 0.01 and
0.05, comparing each test substance-treated group to the control group. Each mean was
presented with the standard deviation (S.D.), standard error (S.E.; except for detailed
clinical observation parameters), and the number of animals (N) used to calculate the
mean. Due to the use of significant figures and the different rounding conventions
inherent in the types of software used, the means and standard deviations on the summary
and individual tables may differ slightly. Data obtained from nongravid animals were
excluded from statistical analyses following the mating period.
Mean gestation lengths, former implantation sites, unaccounted-for sites, numbers of

pups born, live litter sizes, and continuous detailed clinical observation data were
analyzed by Dunnett's test (Dunnett, 1964), comparing the test substance-treated groups
to the control group.
Mean litter proportions (percent per litter) of pup viability and males per litter were
subjected to the Kruskal-Wallis nonparametric ANOVA test to determine intergroup
differences (Kruskal and Wallis, 1952). If the ANOVA revealed significant (p<0.05)
intergroup variance, Dunns test (Dunn, 1964) was used to compare the test
substance-treated groups to the control group. Detailed clinical observation data which
yielded scalar and descriptive data of the control group were compared to each treated
group by the Fishers Exact Test (Steel and Torrie, 1980).
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Statistical analyses of body weights, food consumption, developmental landmarks, brain

morphometry, organ weights, motor activity, auditory startle response, and Biel maze
data were performed by BioSTAT Consultants, Inc, Portage, MI. The results of these
analyses are presented in Appendix J.
5.3.1. BODY WEIGHT AND FOOD CONSUMPTION DATA

Body weight and food consumption data for gestation days 0 through 20 and lactation
days 1 through 21 and body weight gain data during gestation (gestation days 0-7, 7-14,
and 14-20) were analyzed separately with a repeated measures analysis of variance
(RANOVA). Factors in the model included fixed effects for treatment group (TRT),
gestation or lactation day (TIME), and the TRT*TIME interaction term; COHORT was
used as a blocking factor. The covariance structure was selected by comparing Akaikes
Information Criterion (AIC). The Kenward-Rogers adjustment for denominator degrees
of freedom was applied. If the TRT*TIME interaction was significant, Dunnetts test
(Dunnett, 1964) was conducted for each individual day. If the TRT*TIME interaction
was not significant, Dunnetts test was conducted overall across the pooled days only.
Cumulative gestation body weight gain (gestation days 0-20) was analyzed with analysis
of variance (ANOVA). Factors in the model included fixed effect TRT with COHORT
as a blocking factor. Pairwise comparisons were made for each individual test substance-
treated group with the control group using Dunnetts test (Dunnett, 1964). Dams that
failed to deliver offspring were excluded from all statistical analyses.
Pre-culling (PND 1 and 4) and post-culling (PND 4, 7, 11, 14, 17, and 21) pup body
weights and post-culling pup body weight gains (PND 4-7, 7-14, and 14-21) were
analyzed separately with a RANOVA. Factors in the model included random effects for
LITTER, fixed effects for TRT, SEX, and postnatal day (TIME), and the interaction
terms TRT*SEX, TRT*TIME, and TRT*SEX*TIME; COHORT was used as a blocking
factor. For these parameters, the first examination was whether the TRT*SEX and/or
TRT*SEX*TIME interaction was significant. If either interaction was significant, the
analysis was conducted, by sex, with a RANOVA including factors in the model for
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random effects of LITTER, fixed effects for TRT and TIME, and the interaction term
TRT*TIME; COHORT was using as a blocking factor. The covariance structure for the
RANOVA model was selected by comparing the AIC. The Kenward-Rogers adjustment
for denominator degrees of freedom was applied. In the final RANOVA model,
Dunnetts test was used for make pairwise comparisons of each individual treatment
group with the control group. If the TRT*TIME interaction was significant, Dunnetts
test was conducted for each individual day. If the TRT*TIME interaction was not
significant, Dunnetts test was conducted overall across the pooled days only.
Pre-culling pup body weight gain (PND 1-4) was analyzed with a nested ANOVA.
Factors in the model included random effects for LITTER and fixed effects of TRT and
SEX with COHORT as a blocking factor. For these parameters, the first examination
was whether the TRT*SEX interaction was significant. If the interaction was significant,
the analysis was conducted, by sex, with a nested ANOVA including factors in the model
for random effects for LITTER and fixed effects for TRT; COHORT was used as a
blocking factor. The Kenward-Rogers adjustment for denominator degrees of freedom
was applied. Pairwise comparisons were made for each individual test substance-treated
group with the control group using Dunnetts test (Dunnett, 1964).
F1 body weights for PND 28-70 were analyzed separately with a RANOVA. Factors in
the model included fixed effects of TRT, SEX, and postnatal day (TIME) and the
interaction terms TRT*SEX, TRT*TIME, and TRT*SEX*TIME; COHORT was used as
a blocking factor. For these parameters, the first examination was whether the TRT*SEX
and/or TRT*SEX*TIME interaction was significant. If either interaction was significant,
the analysis was conducted, by sex, with a RANOVA including factors in the model for
fixed effects for TRT and TIME and the interaction term TRT*TIME; COHORT was
used as a blocking factor. The covariance structure for the RANOVA model was
selected by comparing the AIC. The Kenward-Rogers adjustment for denominator
degrees of freedom was applied. In the final RANOVA model, Dunnetts test was used
to make pairwise comparisons of each individual treatment group with the control group.
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If the TRT*TIME interaction was significant, Dunnetts test was conducted for each
individual day. If the TRT*TIME interaction was not significant, Dunnetts test was
conducted overall across the pooled days only.
5.3.2. ORGAN WEIGHTS

Maternal organ weights were analyzed with analysis of covariance (ANCOVA). Factors
in the model included fixed effect TRT with COHORT as a blocking factor and final
body weight as a covariate. Pairwise comparisons were made for each individual test
substance-treated group with the control group using Dunnetts test. Organ weight ratios
relative to final body weights were not statistically analyzed.
5.3.3. DEVELOPMENTAL LANDMARKS

The mean day of attainment for surface righting was analyzed with a nested ANOVA.
Factors in the model included random effects for LITTER, fixed effects for TRT and
SEX, and the interaction term TRT*SEX; COHORT was used as a blocking factor. The
first examination was whether the TRT*SEX interaction was significant. If the
interaction was significant, the analysis was conducted, by sex, with a nested ANOVA
including factors in the model for random effects for LITTER and fixed effects for TRT;
COHORT was used as a blocking factor.
The mean day of attainment for balanopreputial separation (male pups) and vaginal
separation (female pups) was analyzed, individually, with a nested ANOVA. Factors in
the model included random effects for LITTER and fixed effects for TRT; COHORT was
used as a blocking factor.
For all developmental landmark nested ANOVA analyses, the Kenward-Rogers

adjustment for denominator degrees of freedom were applied and pairwise comparisons
were made for each individual treatment group with the control group using Dunnetts
test.
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5.3.4. MOTOR ACTIVITY

5.3.4.1. MOTOR ACTIVITY WITHIN SESSIONS - PND 13, 17, AND 21
Total counts from six 10-minute intervals were analyzed, by session, with a RANOVA.
Factors in the model included random effects for LITTER, fixed effects for TRT, SEX,
and TIME interval, and the interaction terms TRT*SEX, TRT*TIME, and
TRT*SEX*TIME; COHORT was used as a blocking factor. For these parameters, the
first examination was whether the TRT*SEX and/or TRT*SEX*TIME interaction was
significant. If either interaction was significant, the analysis was conducted, by sex, with
a RANOVA. Factors in the model included fixed effects for TRT and TIME and the
interaction term TRT*TIME; COHORT was used as a blocking factor. The covariance
structure for the RANOVA model was selected comparing the AIC. The
Kenward-Rogers adjustment denominator degrees of freedom was applied. In the final
RANOVA model, Dunnetts test was used to make pairwise comparisons of each
individual treatment group with the control group. If the TRT*TIME interaction was
significant, Dunnetts test was conducted for each individual time interval. If the
TRT*TIME interaction was not significant, Dunnetts test was conducted overall across
the pooled time intervals only.
5.3.4.2. MOTOR ACTIVITY ACROSS SESSIONS - PND 13, 17, AND 21

Cumulative total counts from six 10-minute SESSION intervals were analyzed with a
RANOVA. Factors in the model included random effects for LITTER, fixed effects for
TRT, SEX, and SESSION, and the interaction terms TRT*SEX, TRT*SESSION, and
TRT*SEX*SESSION; COHORT was used as a blocking factor. For these parameters,
the first examination was whether the TRT*SEX and/or TRT*SEX*SESSION interaction
was significant. If either interaction was significant, the analysis was conducted, by sex,
with a RANOVA. Factors in the model included fixed effects for TRT and SESSION
and the interaction term TRT*SESSION; COHORT was used as a blocking factor. The
covariance structure for the RANOVA model was selected by comparing AIC. The
Kenward-Rogers adjustment for denominator degrees of freedom was applied. In the
final RANOVA model, Dunnetts test was used to make pairwise comparisons of each
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individual treated group with the control group. If the TRT*SESSION interaction was
significant, Dunnetts test was conducted for each individual session. If the
TRT*SESSION interaction was not significant, Dunnetts test was conducted overall
across the pooled sessions only.
5.3.4.3. MOTOR ACTIVITY WITHIN SESSION - PND 61

Total counts from six 10-minute time intervals were analyzed with a RANOVA. Factors
in the model included fixed effects for TRT, SEX, and TIME and the interaction terms
TRT*SEX, TRT*TIME, and TRT*SEX*TIME; COHORT was used as a blocking factor.
For these parameters, the first examination was whether the TRT*SEX and/or
TRT*SEX*TIME interaction was significant. If either interaction was significant, the
analysis was conducted, by sex, with a RANOVA. Factors in the model included fixed
effects for TRT and TIME and the interaction term TRT*TIME; COHORT was used as a
blocking factor. The covariance structure for the RANOVA model was selected by
comparing the AIC. The Kenward-Rogers adjustment for denominator degrees of
freedom was applied. In the final RANOVA model, Dunnetts test was used to make
pairwise comparisons of each individual treated group with the control group. If the
TRT*TIME interaction was significant, Dunnetts test was conducted for each individual
time interval. If TRT*TIME was not significant, Dunnetts test was conducted overall
across the pooled time intervals only.
5.3.5. AUDITORY STARTLE RESPONSE

5.3.5.1. AUDITORY STARTLE RESPONSE WITHIN SESSION - PND 20
Max (N) was analyzed with a RANOVA. Factors in the model included random effects
for LITTER, fixed effects for TRT, SEX, and TRIAL block, and the interaction terms
TRT*SEX, TRT*TRIAL, and TRT*SEX*TRIAL; COHORT was used as a blocking
TRT*SEX*TRIAL interaction was significant. If either interaction was significant, the
effects for TRT and TRIAL and the interaction term TRT*TRIAL; COHORT was used
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as a blocking factor. The covariance structure for the RANOVA model was selected by
pairwise comparisons of each individual treatment group with the control group. If the
TRT*TRIAL interaction was significant, Dunnetts test was conducted for each
individual trial block. If TRT*TRIAL was not significant, Dunnetts test was conducted
overall across the pooled trial blocks only.
5.3.5.2. AUDITORY STARTLE RESPONSE WITHIN SESSION - PND 60

Max (N) was analyzed with a RANOVA. Factors in the model included fixed effects for
TRT, SEX, and TRIAL block and the interaction terms TRT*SEX, TRT*TRIAL, and
TRT*SEX*TRIAL; COHORT was used as a blocking factor. For these parameters, the
first examination was whether the TRT*SEX and/or TRT*SEX*TRIAL interaction was
a RANOVA. Factors in the model included fixed effects for TRT and TRIAL and the
interaction term TRT*TRIAL; COHORT was used as a blocking factor. The covariance
structure for the RANOVA model was selected by comparing the AIC. The
individual treatment group with the control group. If the TRT*TRIAL interaction was
significant, Dunnetts test was conducted for each individual trial block. If TRT*TRIAL
was not significant, Dunnetts test was conducted overall across the pooled trial blocks
only.
5.3.6. BIEL MAZE

The number of errors for learning paths A and B and memory path A were statistically
analyzed individually. Time to escape was reported but not statistically analyzed.
5.3.6.1. BIEL MAZE - PND 22

Analyses were conducted with a RANOVA. Factors in the model included random
effects for LITTER, fixed effects for TRT, SEX, and TRIAL, and the interaction terms
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TRT*SEX, TRT*TRIAL, and TRT*SEX*TRIAL; COHORT was used as a blocking

TRT*SEX*TRIAL interaction was significant. If either interaction was significant, the
effects for TRT and TRIAL and the interaction term TRT*TRIAL; COHORT was used
as a blocking factor. The covariance structure for the RANOVA model was selected by
pairwise comparisons of each individual treatment group with the control group. If the
TRT*TRIAL interaction was significant, Dunnetts test was conducted for each
individual trial. If the TRT*TRIAL interaction was not significant, Dunnetts test was
conducted overall across the pooled trial blocks.
5.3.6.2. BIEL MAZE - PND 62

Analyses were conducted with a RANOVA. Factors in the model included fixed effects
for TRT, SEX, and TRIAL and the interaction terms TRT*SEX, TRT*TRIAL, and
TRT*SEX*TRIAL; COHORT was used as a blocking factor. For these parameters, the
first examination was whether the TRT*SEX and/or TRT*SEX*TRIAL interaction was
a RANOVA. Factors in the model included fixed effects for TRT and TRIAL and the
interaction term TRT*TRIAL; COHORT was used as a blocking factor. The covariance
structure for the RANOVA model was selected by comparing the AIC. The
individual treatment group with the control group. If the TRT*TRIAL interaction was
significant, Dunnetts test was conducted for each individual trial. If the TRT*TRIAL
interaction was not significant, Dunnetts test was conducted overall across the pooled
trial blocks.
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5.3.7. BRAIN MEASUREMENTS AND BRAIN MORPHOMETRY

The acceptable Type I error rate was set to be 0.05, except as noted otherwise. Absolute
brain weights, brain width, brain length, and microscopic morphometric measurements
collected on PND 21 and 72 were analyzed, including data from one pup/litter resulting
in 10 pups/sex/exposure group.
The data were analyzed separately for PND 21 and 72. First, brain weight, brain length,
and brain width were analyzed using a multivariate analysis of variance (MANOVA)
with TRT, SEX, and TRT*SEX as fixed factors and COHORT as a blocking factor. The
first examination was the TRT*SEX interaction. If that effect was not statistically
significant, the overall TRT factor was tested for statistical significance for the combined
sexes. If TRT was statistically significant, linear contrasts, as part of the MANOVA
across the dependent variables, brain weight, brain length, and brain width was used to
test for pairwise differences between each exposure group and the control group. The
Type I error rate was corrected for multiple comparisons between the control group and
each of the test substance exposure groups by dividing the original Type I error rate of
0.05 by the square root of the number of comparisons. The Type I error rate for these
comparisons was then 0.02.
If the TRT*SEX interaction effect was statistically significant, the MANOVA analysis
was conducted for each sex separately. The overall TRT factor was examined for
statistical significance for each sex separately. If TRT was statistically significant, linear
contrasts, as part of the MANOVA across the dependant variables, brain weight, brain
length, and brain width was used to test for pairwise differences between each test
substance-treated group and the control group. The Type I error rate was corrected for
multiple comparisons between the control group and each of the test substance-treated
groups as described above. The Type I error rate for these comparisons was 0.02.
For the cases where TRT was statistically significant in the MANOVA, as described
above, all the endpoints from the microscopic examination, which included at least
two measurements each from the neocortical, hippocampal and cerebellar areas, was
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analyzed statistically using a MANOVA with TRT, SEX, and TRT*SEX as fixed factors.
The first examination was the TRT*SEX interaction. If that effect was not statistically
significant, the overall TRT factor was examined for statistical significance for the
combined sexes. If TRT was statistically significant, linear contrasts, as part of the
MANOVA across the dependant variables from the microscopic examination was used to
test for pairwise differences between each test substance-treated group and the control
group. The Type I error rate was corrected for multiple comparisons between the control
group and each of the test substance-treated groups as described above. The Type I error
rate for these comparisons was 0.02. If TRT was not statistically significant when
analyzing microscopic parameters, no additional statistical analysis were conducted.
If the TRT*SEX interaction effect was statistically significant, the MANOVA analysis
were conducted for each sex separately. The overall TRT factor was examined for
statistical significance for each sex separately. If TRT was statistically significant, linear
contrasts, as part of the MANOVA across the dependant variables from the microscopic
examination was used to test for pairwise differences between each test substance-treated
group and the control group. The Type I error rate was corrected for multiple
comparisons between the control group and each of the test substance-treated groups as
described above. The Type I error rate for these comparisons was 0.02. If TRT was not
statistically significant when analyzing microscopic parameters, no additional statistical
analysis were conducted.
For the case where TRT was not statistically significant in the MANOVA analysis of
perfused brain weight, brain length, and brain width, the endpoints from the microscopic
examination were then individually analyzed using ANOVA with TRT, SEX, and
TRT*SEX as fixed factors and COHORT as a blocking factor at the two time periods.
The first examination was the TRT*SEX interaction. If that effect was not statistically
significant, Dunnetts test was conducted across the combined sexes to test for pairwise
differences between each test substance-treated group and the control group at each time
point. If the TRT*SEX interaction effect was statistically significant, the analysis was
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conducted for each sex and each time point separately. Dunnetts test was then
conducted for each sex at each time point to test for pairwise differences between each
test substance-treated group and the control group.
5.4. DATA RETENTION

The Sponsor has title to all documentation records, raw data, specimens, or other work
product generated during the performance of the study. All work product generated by
WIL Research Laboratories, LLC, including raw paper data and specimens, are retained
in the Archives at WIL Research Laboratories, LLC, as specified in the study protocol.
Appropriate supporting documentation for statistical analyses conducted and reported by
BioSTAT Consultants, Inc., is maintained in the Archives at WIL Research Laboratories,
LLC.
A reserve sample of the test substance, pertinent electronic storage media, and the
original final report are retained in the Archives at WIL Research Laboratories, LLC, in
compliance with regulatory requirements.
Page 64 of 4796
6. RESULTS
6.1. ANALYTICAL CHEMISTRY
Analytical Chemistry Report: Appendix C
Results of the analyses of the dietary formulations are summarized below.
Text Table 1. Results of Homogeneity and Concentration Analyses for the Initial
Diet used in the Study
Group 2 Group 3 Group 4 Group 5 Group 6
(0.15 ppm) (1.5 ppm) (75 ppm) (750 ppm) (2250 ppm)
Homogeneity Assessment of the 7 and 8 July 2008 Formulations*

Mean Concentration (ppm) 0.139 1.44 66.9 657 1935
RSD (%) 2.7 0.75 0.59 2.5 0.99
Mean % of Target 92.9 96.3 89.2 87.6 86.0
* = Homogeneity was verified prior to the start of the study on formulations that were used
for exposure to Cohort 1 at initiation of test diet treatment. The 0.15 and 1.5 ppm group
formulations were prepared on 7 July 2008 and the 75, 750, and 2250 ppm group
formulations were prepared on 8 July 2008.
Text Table 2. Results of Concentration Analyses of Subsequent Diet Preparations

used in the Study
Mean Concentration, ppm (% of Target)
Group 2 Group 3 Group 4 Group 5 Group 6
Date of Preparation (0.15 ppm) (1.5 ppm) (75 ppm) (750 ppm) (2250 ppm)
21 July 2008 0.163 (109) 1.48 (98.9) 69.9 (93.2) 726 (96.8) 2103 (93.4)
4 August 2008 0.160 (107) 1.69 (113) 75.5 (101) 786 (105) 2337 (104)
21 August 2008 0.160 (106) 1.52 (101) 69.5 (92.7) 738 (98.3) 2212 (98.3)
2 September 2008 0.147 (97.8) 1.51 (101) 70.5 (93.9) 715 (95.3) 2183 (97.0)
15 September 2008 0.0723 (48.2)* 0.862 (57.5)* 64.9 (86.6) 661 (88.1) 1994 (88.6)
19 September 2008 0.169 (113) 1.58 (105) NA NA NA
* = The 0.15 and 1.5 ppm group formulations prepared on 15 September 2008 were below
the acceptable concentrations. Therefore, these diets were not used for exposure and
were reformulated on 19 September 2008.
NA = Not applicable.
The analyzed dietary formulations were within the WIL Research Laboratories, LLCs,
standard operating procedures range (85% to 115%) and were homogeneous, with the
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following exceptions: The 0.15 and 1.5 ppm group formulations prepared on
15 September 2008 were 48.2% and 57.5% of target concentrations, respectively.
However, these test diets were not used for exposure on study and were subsequently
reformulated. The control group diet prepared on 21 July 2008 contained 0.0327 ppm
bisphenol A. As a result, this diet was not offered to control group animals. In all other
dietary formulations prepared for exposure to control group animals, test substance was
not detected or was below the lower limit of quantitation (LLOQ). Based on these
results, the protocol-specified exposure levels of test substance were administered to the
animals.
6.2. F0 MATERNAL GENERATION

6.2.1. PREGNANCY STATUS
Summary Data: Table 1
Historical Control Data: Appendix K
There were no test substance-related effects on pregnancy rates; the values in the control,
0.15, 1.5, 75, 750, and 2250 ppm groups were 95.8%, 95.8%, 100.0%, 100.0%, 100.0%,
and 100.0%, respectively. One female each in the control and 0.15 ppm groups failed to
deliver and were determined to be nongravid at necropsy.

Summary Data: Table 1, Table 2
Individual Data: Table A1
In the 2250 ppm group, female no. 23237 was found dead during the process of
parturition on lactation day 0. This female delivered 12 pups and had three dead fetuses
and one early resorption retained in utero at necropsy. No remarkable clinical findings
prior to death were noted for this female, and the only other gross finding noted at
necropsy was dark red stomach contents. There were no indications of the cause of death
in the tissues (liver and kidneys) examined microscopically. Based on these findings, the
single mortality in the 2250 ppm group, in the absence of any adverse clinical findings or
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other occurrences of mortality or moribundity at any exposure level in this study, was not
attributed to test substance exposure. All other F0 females survived to the scheduled
necropsies.
No test substance-related clinical findings were noted in the F0 females at the daily
examinations. Findings noted in the test substance-treated groups, including hair loss on
various body surfaces and red material around the nose, occurred infrequently and/or at
similar frequencies in the control group.
6.2.3. DETAILED CLINICAL OBSERVATIONS

Individual Data: Table A2, Table A3
Scoring Criteria: Appendix G
Positive Control Data: Appendix L
No test substance-related findings were observed for F0 females at the detailed clinical
observations. A statistically significantly higher number of females in the 750 ppm group
(four females) was noted with red deposits around the nose compared to the control group
(zero females) on lactation day 10. However, a similar increase in the incidence of this
finding was not observed at any other time point in this group on which detailed clinical
observations were conducted (gestation days 10 and 15 and lactation day 21) or at the
daily examinations. Furthermore, a similar incidence of red deposits around the nose was
observed in the control group on lactation day 21. Thus, in the absence of any trend
towards an increase in this finding at any other exposure level, the increase in animals
with red deposits around the nose on lactation day 10 in the 750 ppm group was not
attributed to test substance exposure. No other differences were apparent between the
control and test substance-treated groups when the detailed clinical observation data were
evaluated for gestation days 10 and 15 and lactation days 10 and 21.
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6.2.4. BODY WEIGHTS

6.2.4.1. GESTATION
Summary Data: Table 5, Table 6; Figure 1
Statistical Analysis Summary: Appendix J
Test substance-related lower mean body weight gains were noted in the 750 and
2250 ppm groups following the onset of the exposure period (gestation days 0-7); these
differences from the control group were statistically significant. Mean body weight gains
in these groups were similar to the control group during gestation days 7-14 and 14-20.
As a result of the initial reductions, mean body weight gains in the 750 and 2250 ppm
groups were statistically significantly lower (9.5% and 22.4%, respectively) compared to
the control group for the overall gestation exposure period (gestation days 0-20). In
addition, mean body weights were 4.7% to 5.2% and 8.6% to 10.7% lower in these same
respective groups during gestation days 3-20; these differences from the control group
were statistically significant.
Mean body weights and body weight gains in the 0.15, 1.5, and 75 ppm groups were
unaffected by test substance exposure during gestation and not statistically significantly
different from the control group.
6.2.4.2. LACTATION
Summary Data: Table 7, Table 8; Figure 2
As a result of the initial reductions in mean body weight gains during gestation days 0-7,
the mean body weights for the 750 ppm (not statistically significant) and 2250 ppm
(statistically significant) groups were lower than the control group on lactation day 1.
During lactation days 1-17, the mean body weights in the 750 and 2250 ppm groups
ranged from 3.8% to 5.2% and 8.1% to 9.6% lower, respectively, compared to the control
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group; these differences achieved statistical significance on lactation days 11 and 14 in

the 750 ppm group and lactation days 1-17 in the 2250 ppm group. Mean body weight
changes in the 0.15, 1.5, 75, 750, and 2250 ppm groups were unaffected by test diet
exposure during lactation. A mean body weight gain (8 g) was noted in the 2250 ppm
group during lactation days 17-21 compared to a mean body weight loss (-17 g) in the
control group, resulting in a slightly higher mean body weight gain for the overall
lactation period (lactation days 1-21). Mean body weights in the 750 and 2250 ppm
groups recovered to be within 2.1% and 2.4%, respectively, of the control group by
lactation day 21 due to expected mean body weight loss in the control group during
lactation days 17-21. Mean body weights in the 0.15, 1.5, and 75 ppm groups were
similar to the control group throughout lactation.
6.2.5. FOOD CONSUMPTION

6.2.5.1. GESTATION
Mean food consumption, evaluated as g/animal/day, in the 2250 ppm group was
generally reduced throughout gestation (gestation days 0-20) compared to the control
group. Differences from the control group achieved statistical significance during
gestation days 0-3, 3-7, and 10-14 and corresponded to a reduced mean body weight gain
during the first week (gestation days 0-7) of test diet exposure.
In the 750 ppm group, mean food consumption was statistically significantly lower
during gestation days 0-3, 3-7, and 7-10 and similar to the control group throughout the
remainder of the gestation period (gestation days 10-14 and 14-20). The reductions in
mean food consumption corresponded to a reduced mean body weight gain during the
first week (gestation days 0-7) of test diet exposure.
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Mean food consumption in the 0.15, 1.5, and 75 ppm groups was unaffected by test
substance exposure during gestation and not statistically significantly different from the
control group.
6.2.5.2. LACTATION
Mean food consumption, evaluated as g/animal/day, in the 0.15, 1.5, 75, 750, and
2250 ppm groups was unaffected by test substance exposure during lactation, with the
exception of a statistically significantly lower mean food consumption during lactation
days 7-11 in the 750 ppm group that was not considered to be test substance-related.
6.2.5.3. TEST SUBSTANCE CONSUMPTION

Summary Data: Table 11, Table 12; Figure 3, Figure 4
The mean doses of bisphenol A, consumed by the dams, are presented below. Values for
the entire lactation period of all groups were elevated, as food consumption increased to
support milk production.
Calculated Test Substance Consumption

Mean (Range) mg/kg/daya
Nominal
Dietary Level Gestation Lactation
0.15 ppm 0.01 (0.01 - 0.01) 0.03 (0.02 - 0.03)
1.5 ppm 0.12 (0.10 - 0.13) 0.25 (0.18 - 0.31)
75 ppm 5.85 (5.32 - 6.43) 13.1 (9.31 - 16.1)
750 ppm 56.4 (51.1 - 60.9) 129 (86.9 - 158)
2250 ppm 164 (93.8 - 196) 410 (288 - 527)
Summation of mean test substance consumption for the specified interval
a= Number of days or intervals assessed
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6.2.6. GESTATION LENGTH AND PARTURITION

No test substance-related effects were noted on mean gestation lengths at any exposure
level. Mean F0 gestation lengths in the test substance-treated groups were similar to the
control group value and not statistically significantly different. The mean gestation
lengths in the 0.15, 1.5, 75, 750, and 2250 ppm groups were 21.7, 21.7, 22.0, 21.8, and
21.8 days, respectively, compared to mean gestation lengths of 21.7 days in the
concurrent control group and 21.8 days in the WIL historical control data. No test
substance-related effects were noted on parturition at any exposure level. As described
above, female no. 23237 in the 2250 ppm group was found dead during parturition on
lactation day 0 which was not considered test substance-related.
6.2.7. ANATOMIC PATHOLOGY (F0)

6.2.7.1. MACROSCOPIC EXAMINATIONS
Summary Data: Table 14, Table 15, Table 16, Table 17, Table 18
Individual Data: Table A14, Table A15, Table A16, Table A17, Table A18
Pathology Report: Appendix H
No test substance-related gross findings were observed at any exposure level at the
scheduled necropsies. One female each in the control and 0.15 ppm groups failed to
deliver and were determined to be nongravid at necropsy; the only macroscopic finding
for these females was clear fluid in the uterus for female no. 26528 in the control group.
No macroscopic findings were noted for the two females each in the 75 and 750 ppm
groups that were euthanized on lactation day 4 due to the pup sex ratio criteria not being
met. At the lactation day 21 necropsy, macroscopic findings noted in the test
substance-treated groups generally occurred in single females.
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At the lactation day 21 necropsy, no test substance-related effects were observed on the
number of former implantation sites and the number of unaccounted-for sites.
At necropsy, the female in the 2250 ppm group that was found dead on lactation day 0
was observed with three dead fetuses and one early resorption in utero. The only other
gross finding noted for this female was dark red stomach contents.
6.2.7.2. ORGAN WEIGHTS

There were no statistically significant or test substance-related alterations in mean kidney

and liver weights in F0 females at any exposure level when analyzed with final body
weight as the covariate. Liver and kidney weights, relative to final body weights, are also
shown on Table 19.
6.2.7.3. MICROSCOPIC EXAMINATIONS

Summary Data: Table 20, Table 21, Table 22, Table 23
Individual Data: Table A13, Table A14, Table A15, Table A16, Table A17
There were no microscopic alterations associated with test substance exposure in the
livers and kidneys of any F0 females at any exposure level. Histopathological findings
were generally consistent with background lesions or did not occur in a dose-related
manner.
Page 72 of 4796
6.3. F1 LITTER DATA

6.3.1. PND 0 LITTER DATA AND POSTNATAL SURVIVAL
Individual Data: Table A21, Table A22, Table A23
The mean number of pups born, live litter size, percentage of males per litter at birth, and
postnatal survival between birth and weaning were unaffected at all exposure levels.
6.3.2. GENERAL PHYSICAL CONDITION

No clinical observations noted for F1 pups in this study were attributed to test substance
exposure. In the 750 ppm group, three pups from one litter (nos. 23249-04, -06, and -10)
were noted with reddened forelimbs and/or hindlimbs on PND 11 or 14; all three pups
were subsequently found dead. However, because these findings were limited to a single
litter and occurred in a manner that was not exposure-related, they were not considered
test substance-related. Pups (litters) that were found dead or euthanized in extremis
numbered 9(8), 14(9), 15(8), 22(8), 14(6), and 11(7) in the control, 0.15, 1.5, 75, 750, and
2250 ppm groups, respectively. Four (4), 2(2), 3(2), 6(6), 4(4), and 4(3) pups (litters) in
the same respective groups were missing and presumed to have been cannibalized. In
addition, 12 pups (one litter) in the 2250 ppm group were sent to necropsy on PND 0 due
to the death of the dam (no. 23237).
Page 73 of 4796
6.3.3. OFFSPRING BODY WEIGHTS

Summary Data: Table 27, Table 28; Figure 5, Figure 6
On PND 1, mean male and female pup body weights in the 750 and 2250 ppm groups
were similar to the control group. During PND 1-4 (pre-culling), mean combined male
and female pup body weight gains in these groups were similar to the control group.
Following culling on PND 4, mean male and female pup body weight gains in the 750
and 2250 ppm groups were similar to the control group during PND 4-7, statistically
significantly lower during PND 7-14, and similar to the control group during PND 14-21.
Mean male and female pup weights in these groups were generally similar to the control
group on PND 4 (pre- and post-culling) and 7. The mean female pup body weight in the
2250 ppm group on PND 4 (pre-culling) was statistically significantly lower (5.6%)
compared to the control group. Because of the reduced mean male and female pup body
weight gains during PND 7-14, mean male and female pup body weights in the 750 ppm
group were statistically significantly lower (4.7% to 5.6%) on PND 14 and/or 17 before
recovering by PND 21, and mean male and female body weights in the 2250 ppm group
were statistically significantly lower (4.8% to 8.3%) beginning on PND 11 and
continuing through the end of the pre-weaning period (PND 21) compared to the control
group.
Mean pup body weights and body weight changes in the 0.15, 1.5, and 75 ppm group
males and females were unaffected by test substance exposure throughout the postnatal
period. Statistically significantly higher mean male body weight gains were noted in 0.15
and 75 ppm groups during PND 14-21 compared to the control group. In addition, mean
female pup body weights in the 75 ppm group were statistically significantly higher on
PND 4 (pre-culling), mean male body weights in the 75 ppm group were statistically
significantly higher during PND 4 (pre- and post-culling) through 11 and on PND 21, and
Page 74 of 4796
the mean male body weight in the 0.15 ppm group was statistically significantly higher
on PND 21 compared to the control group. However, differences from the control group
were generally slight ( 8.5%) and because no dose-related trends were apparent and no
consistent temporal trends were observed, the differences in mean body weights in the
0.15 and 75 ppm groups were not attributed to test substance exposure. In addition, at
75 ppm there were slightly fewer pups per litter at birth and gestation length was 0.3 days
longer; both of these factors may have contributed to the higher mean pup body weights
in this group. There were no other statistically significant differences from the control
group.
6.3.4. NECROPSIES OF PUPS FOUND DEAD OR EUTHANIZED IN EXTREMIS

The numbers of pups (litters) found dead or euthanized in extremis during the
pre-weaning period (PND 0-21) numbered 9(8), 14(9), 15(8), 22(8), 14(6), and 11(7) in
the control, 0.15, 1.5, 75, 750, and 2250 ppm groups, respectively. No gross findings that
could be attributed to parental test substance exposure were noted at the necropsies of
pups that were found dead or euthanized in extremis. Aside from the presence or absence
of milk in the stomach, the following findings commonly seen at a low incidence for this
strain of rats were noted. In the 2250 ppm group, pup no. 23192-05 had
two developmental malformations (situs inversus and lobular dysgenesis of the lungs).
Pup no. 26462-04 in the 2250 ppm group was noted with a swollen liver and a
hemorrhagic ring around the right iris. Because these findings were noted in single pups,
they were not attributed to test substance exposure. In the 750 ppm group, pup
nos. 23249-06 and 23249-10 had reddened hindpaws; pup no. 23249-10 also had red
fluid in the bladder. Because these findings occurred in a single litter and were not noted
at any other exposure level, they were not attributed to test substance exposure. In the
75 ppm group, pup no. 26516-07 was noted with renal papilla not fully developed (Woo
Page 75 of 4796
and Hoar Grade 1); because this finding was noted in a single pup, it was not considered
test substance-related. No other gross findings were noted in any pups from any group.
6.3.5. NECROPSIES OF PUPS EUTHANIZED DUE TO DEATH OF DAM, SEX

RATIO CRITERIA NOT MET, OR ON PND 21 NOT SELECTED FOR
NEUROPATHOLOGICAL EVALUATION
No gross findings that could be attributed to test substance exposure were noted at the
necropsy of pups euthanized due to the death of the dam, on PND 4 due to sex ratio
criteria not met, or on PND 21. Gross findings observed on PND 21 included dilated
renal pelves in pup nos. 26459-09 and 26511-11 in the 75 and 2250 ppm groups,
respectively, and eye atrophy in pup no. 26537-04 in the 750 ppm group. No other gross
findings were noted.
6.4. DEVELOPMENTAL LANDMARKS

6.4.1. SURFACE RIGHTING RESPONSE
Surface righting response in the F1 male and female pups was not affected by test
substance exposure, with no statistically significant difference for any test
substance-treated group. The mean ages of attainment were 6.7, 6.6, 6.3, 6.2, 6.3, and
6.3 days for the F1 animals (combined sexes) in the control, 0.15, 1.5, 75, 750, and
2250 ppm groups, respectively.
Page 76 of 4796
6.4.2. BALANOPREPUTIAL SEPARATION

Mean ages of attainment of balanopreputial separation were unaffected by test substance

exposure, with no statistically significant difference for any test substance-treated group.
The mean ages of attainment of balanopreputial separation were 46.0, 44.8, 44.3, 44.6,
and 45.0 days in the 0.15, 1.5, 75, 750, and 2250 ppm groups, respectively, compared to
44.8 days in the control group. Additionally, mean body weights at the age of attainment
in the test substance-treated groups were similar to the control group.
6.4.3. VAGINAL PATENCY

Mean ages of attainment of vaginal patency were unaffected by test substance exposure,
with no statistically significant difference for any test substance-treated group. The mean
ages of attainment of vaginal patency were 32.4, 32.9, 32.8, 33.3, and 32.7 days in the
0.15, 1.5, 75, 750, and 2250 ppm groups, respectively, compared to 32.3 days in the
control group. Additionally, mean body weights at the age of attainment in the test
substance-treated groups were similar to the control group.
Page 77 of 4796
6.5. F1 GENERATION
One female and three males in the control and 1.5 ppm groups, respectively, were found
dead or euthanized in extremis following the pre-weaning period. In the 1.5 ppm group,
male no. 26510-09 (Subset B) was found dead on PND 22 and male no. 23208-08
(Subset A) was found dead on PND 56; no remarkable clinical observations were noted
for either of these males. Male no. 23244-07 (Subset B) in the 1.5 ppm group was
euthanized in extremis on PND 24 due to clinical findings of impaired use of both
hindlimbs and excessive vocalization on the day of euthanasia. No remarkable gross
findings were noted at necropsy for any of the three males found dead or euthanized in
extremis. In the absence of any mortality or moribundity at any other exposure level or
any other evidence of toxicity in the 1.5 ppm group, the mortality or moribundity
observed in three males in this group were not attributed to test substance exposure. In
the control group, female no. 23182-11 (Subset A) was found dead on PND 41; no
remarkable clinical or gross findings were noted for this female. All other F1 animals in
Subsets A and B survived to the scheduled necropsies.
No test substance-related clinical findings were noted at the weekly examinations of the
F1 animals. Findings noted in the test substance-treated groups, including hair loss on
various body surfaces, occurred infrequently and/or at similar frequencies in the control
group.
Page 78 of 4796
6.5.2. BODY WEIGHTS

Summary Data: Table 36, Table 37, Table 38; Figure 7, Figure 8
Individual Data: Table A34, Table A35, Table A36, Table A37
Mean post-weaning offspring body weights and body weight gains in the 0.15, 1.5, 75,
750, and 2250 ppm groups were unaffected by test substance exposure, with no
statistically significant difference for any test substance-treated group. Mean female
body weight in the 2250 ppm group was slightly lower (8.0%) on PND 28 due to reduced
mean body weight gain during the pre-weaning period. However, the difference from the
control group did not achieve statistical significance and mean female body weights in
this group were similar to the control group throughout the remainder of the
post-weaning period (PND 35-70).
6.5.3. DETAILED CLINICAL OBSERVATIONS (SUBSET A)

Scoring Criteria: Appendix G
Historical Control Data: Appendix M
No test substance-related effects were noted when detailed clinical observation data were
evaluated on PND 4, 11, 21, 35, 45, and 60. Findings in the test substance-treated groups
were noted infrequently and included the following.
On PND 11 only, two animals from the 750 ppm group and four animals from the
2250 ppm group exhibited irregular jerking movements of limbs, head, and/or body
(recorded as convulsions) and/or jumping with all four feet in the air (recorded as
popcorn seizures). These findings were not statistically significant and occurred during
the same period where statistically significantly reduced mean pup body weight gains
were noted (PND 7-14) in the 750 and 2250 ppm groups. No animals in the control
Page 79 of 4796
group were noted with these findings on any evaluation day. In addition, these findings
were not observed in any animals, including these six animals, at any other age. For
these six animals, there were no other remarkable findings in the other endpoints
examined as part of the detailed clinical observations or in the histopathological
examination of the nervous system. In addition, there were no test substance-related
differences from the control group for the BPA-treated groups (which included these six
animals) for motor activity, auditory startle response, or learning behavior. The historical
control data indicated that these findings have been observed in control animals at PND
11 (two of 244 females and not observed in 243 males). Since the incidence of these
findings was greater than the historical control incidence, a follow-up study was
conducted to determine the reproducibility and, if appropriate, further characterize these
findings (Appendix N). No effects in the DCO, including the clonic movements
observed in this study on PND 11, were evident in the follow-up study (see Section 7.).
In conclusion, the PND 11 observations were not considered to be test substance-related.
The following statistically significant differences from the control group were also
observed: the number of males (six males in the 2250 ppm group) noted to be rearing on
PND 35 was statistically significantly higher compared to the control group (zero males),
the number of females (zero females) asleep in the 1.5 ppm group on PND 35 was
statistically significantly lower compared to the control group (five females), and the
mean number of defecation counts in the 75 ppm group males (0.2 counts) on PND 45
was statistically significantly higher compared to the control group (0.0 counts). Because
these findings were limited to single sexes on one evaluation day each, they were not
attributed to test substance-exposure.
Page 80 of 4796
6.5.4. MOTOR ACTIVITY (SUBSET A)

Summary Data: Table 40, Table 41; Figure 9, Figure 10, Figure 11, Figure 12, Figure 13,
Figure 14, Figure 15, Figure 16
Historical Control Data: Appendix O
Motor activity, as measured by all activity counts, in F1 animals was unaffected by test
substance exposure at 0.15, 1.5, 75, 750, and 2250 ppm when evaluated on PND 13, 17,
21, and 61. The pattern of activity obtained from the six intervals evaluated (0-10, 11-20,
21-30, 31-40, 41-50, and 51-60 minutes) and the overall 60-minute test session values
were comparable to the concurrent control group. There were no statistically significant
differences from the control group when the data were evaluated by repeated measures
analysis. No remarkable shifts in the pattern of habituation occurred in any of the groups
exposed to the test diet when the F1 animals were evaluated at PND 13, 17, 21, and 61.
6.5.5. AUDITORY STARTLE TEST (SUBSET A)

Summary Data: Table 42; Figure 17, Figure 18
Historical Control Data: Appendix P
The auditory startle response habituation paradigm was conducted as a longitudinal

assessment with selected F1 animals evaluated on PND 20 and PND 60. Test substance
exposure at 0.15, 1.5, 75, 750, and 2250 ppm had no significant effect on auditory startle
response amplitude at PND 20 or 60. No effects were noted in the pattern of the
habituation over the entire 50-trial test session at either age.
Page 81 of 4796
6.5.6. BIEL MAZE SWIMMING TRIALS (SUBSETS A AND B)

Summary Data: Table 43, Table 44; Figure 19, Figure 20, Figure 21, Figure 22,
Figure 23, Figure 24
Individual Data: Table A41, Table A42, Table A43, Table A44
Historical Control Data: Appendix Q
Swimming ability on day 1 of the Biel maze assessment (PND 22 or 62) was similar
between the control, 0.15, 1.5, 75, 750, and 2250 ppm groups. Data are presented in
Appendix A.
There were no test substance-related effects observed in the number of errors committed
in either sex at PND 22 or 62. For females on PND 22, the overall mean number of
errors committed in the 0.15 and 2250 ppm groups was statistically significantly lower
than the control group for Path B (Trials 5-10). The mean number of errors for the
control group of PND 22 females in Path B was higher than historical control mean
values (Appendix Q) while the mean number of errors for these test substance-treated
groups was similar to historical control mean values, which contributed to the statistically
significant differences observed for the 0.15 and 2250 ppm groups.
In addition, the overall mean number of errors committed by males in the 0.15 ppm group
for Path A (Trials 1-4) on PND 62 were statistically significantly higher than the control
group mean. However, the mean values for the control group were lower for Trials 3
and 4 than the comparable historical control mean values (Appendix Q) which
contributed to the significant difference in the 0.15 ppm group. Furthermore, the
0.15 ppm group performed similarly to the control animals in Path B on PND 62.
In Path B, the mean number of errors for males and females combined in the 1.5 ppm
group for Trial 7 on PND 62 only were statistically significantly higher than the control
Page 82 of 4796
group. However, the mean number of errors for all other trials in Path B was similar to
the control group means.
In summary, the statistically significant differences noted were considered spurious and
not test substance-related because they did not occur consistently between or within
testing periods, did not demonstrate any evidence of a dose-related trend, and/or resulted
from atypical control group responses.
6.5.7. MACROSCOPIC EXAMINATIONS

6.5.7.1. UNSCHEDULED DEATHS
One female and three males in the control and 1.5 ppm groups, respectively, were found
dead or euthanized in extremis following the pre-weaning period. No remarkable gross
findings were noted for any of these animals at necropsy.
6.5.7.2. ANIMALS EUTHANIZED FOLLOWING PND 22 LEARNING AND

MEMORY (SUBSET B)
At the necropsies of Subset B animals euthanized following completion of the learning

and memory assessments, no gross findings related to test substance exposure were
observed. Gross findings noted in the test substance-treated groups were limited to dark
red areas on the thymus for male no. 23180-07 in the 0.15 ppm group, cystic kidneys for
female nos. 23252-16 and 26464-08 in the 1.5 and 750 ppm groups, respectively, and a
white area on the spleen for female no. 26499-10 in the 75 ppm group. Because these
findings occurred in single animals in the absence of any exposure-related trend, they
were not attributed to test substance exposure.
Page 83 of 4796
6.5.8. NEUROPATHOLOGY
6.5.8.1. PND 21 (SUBSET C)
6.5.8.1.1. MACROSCOPIC EXAMINATIONS
At the necropsies of F1 animals selected for brain weights on PND 21, no test
substance-related gross findings were noted in the brain. In the 1.5 ppm group, female
no. 23208-12 had dark red areas on the brain and female no. 26534-08 had depressed
areas on the brain. Based on the histopathological examination, these findings were
considered to be artifacts from perfusion (Appendix H).
6.5.8.1.2. BRAIN WEIGHTS/BRAIN MEASUREMENTS

There were no test substance-related effects on mean brain weights or mean brain lengths
and widths at any exposure level on PND 21, with no statistically significant differences
for any test substance-treated group.
6.5.8.1.3. QUALITATIVE HISTOPATHOLOGY AND BRAIN MORPHOMETRY

Summary Data: Table 51, Table 52; Figure 25, Figure 26, Figure 27
Historical Control Data: Appendix R
There were no test substance-related histopathologic or morphometric alterations in the

brains of the F1 males and females at any exposure level on PND 21. The following
Page 84 of 4796
incidental alterations were observed. Five pups (two males and one female in the 0.15
ppm group, one female in the 75 ppm group, and one male in the 2250 ppm group) each
had a nest of embryonal cells unilaterally in the lateral caudoputamen. A third male in
the 0.15 ppm group had nests of embryonal cells at the lateral aspect of the caudate
nucleus adjacent to the external capsule. These nests of embryonal cells most closely
resembled the cells of the normal subependymal zone and occurred in the lateral
caudoputamen close to the location of the lateral ventricles. These nests were most likely
migrating cells that did not complete their migration or undergo programmed cell death
by PND 21. The historical control data indicate that ectopic tissue in the basal ganglia of
the brain of PND 21 rats similar to the embryonal cell nests diagnosed in the present
study was observed in one male and one female (of 70 and 69, respectively) control rats.
The occurrence of this finding in the historical control for rats of both sexes, the lack of
an exposure-related response, and the unilateral nature of the finding in the present study
suggest that it is incidental rather than test substance-related.
One female in the 750 ppm group had mild cortical dysplasia in the molecular/plexiform
layer of the cerebral cortex where the normally hypocellular superficial layer either had a
cellular focus in Level 1, or was unusually expanded (focally wider) in Level 4. The
presence of this dysplasia in only one pup and lack of a dose response-relationship
indicated that it was a spontaneous lesion rather than a test substance-related effect.
6.5.8.2. PND 72 (SUBSET A)

6.5.8.2.1. MACROSCOPIC EXAMINATIONS
At the necropsies of F1 animals selected for brain weights on PND 72, no test
substance-related gross findings were noted in the brain or spinal cord. One male each in
the control, 0.15, 1.5, and 75 ppm groups had dark red areas on the brain. Based on
histopathological examination, these findings were considered to be artifacts from
Page 85 of 4796
perfusion (Appendix H). One male in the 0.15 ppm group had depressed areas on the
brain diagnosed as hydrocephalus upon microscopic examination (Appendix H).
Because this latter finding occurred in a single animal it was not attributed to test
substance exposure.
6.5.8.2.2. BRAIN WEIGHTS/BRAIN MEASUREMENTS

There were no test substance-related effects on mean brain weights or mean brain lengths
and widths at any exposure level on PND 72, with no statistically significant difference
for any test substance-treated group.
6.5.8.2.3. QUALITATIVE HISTOPATHOLOGY AND BRAIN MORPHOMETRY

Summary Data: Table 55, Table 56; Figure 28, Figure 29, Figure 30
Historical Control Data: Appendix R
There were no test substance-related histopathologic or morphometric alterations in the

brain or histopathologic alterations in the central and peripheral nervous system tissues of
the F1 males and females at any exposure level on PND 72. Alterations occurred in
single animals and/or in a manner that was not exposure-related. Brain and nervous
system tissues, from additional animals examined because of detailed clinical
observations, had no test substance-related microscopic alterations.
Page 86 of 4796
7. DISCUSSION
The objective of this study was to determine the potential of the test substance,
bisphenol A, to induce functional and/or morphological effects to the nervous system of
offspring following exposure of the mother during pregnancy and lactation. To
accomplish this objective, the study was conducted in accordance with U.S. EPA and
OECD testing guidelines. These guidelines were exceeded by evaluation and external
peer review of neuropathology and brain morphometry for all dose groups, as well as the
concurrent control group, and in the use of five dietary levels of the test substance, as
well as the concurrent control group, ranging from very low to concentrations sufficient
to achieve maternal toxicity. As specified in the guidelines, positive control data, using
reference chemicals to establish the reliability and sensitivity of the test methods at the
appropriate offspring ages used for neurotoxicity endpoints, were developed by WIL
Research Laboratories, LLC and are included in Appendix L.
Actual mean test substance consumption in the 0.15, 1.5, 75, 750, and 2250 ppm groups
was 0.01, 0.12, 5.85, 56.4, and 164 mg/kg/day, respectively, during gestation and 0.03,
0.25, 13.1, 129, and 410 mg/kg/day, respectively, during lactation. F0 maternal survival
was unaffected by test diet exposure. There were no test substance-related effects on
clinical observations, detailed clinical observations, mean liver and kidney weights, gross
findings, or microscopic findings for maternal animals at any exposure level. However,
maternal toxicity was expressed at 750 and 2250 ppm in the F0 generation females by
lower mean body weight gains during gestation (gestation days 0-20) of 9.5% and 22.4%,
respectively.
In the offspring, there were no test substance-related effects on reproductive parameters,

birth weight, postnatal survival, or developmental landmarks at any dietary concentration.
However, F1 pup toxicity was expressed at exposure levels of 750 and 2250 ppm by
reductions in mean male and female pup body weight gains during PND 7-14. This
resulted in lower mean male and female pup body weights during PND 14-17 in the
Page 87 of 4796
750 ppm group (up to 5.6% lower) and PND 11-21 in the 2250 ppm group (up to 8.3%
lower).
No test substance-related effects were observed with respect to DCO, motor activity,
auditory startle, learning and memory, macroscopic examinations and measurements,
neuropathology, or brain morphometry at any dietary concentration at any age. At the
PND 11 detailed clinical observation evaluations, two pups in the 750 ppm group and
four pups in the 2250 ppm group exhibited clonic movements that were recorded as
convulsions and/or popcorn seizures. A follow-up study, to further assess these
observations, was conducted at the highest dietary concentration (2250 ppm) with
conditions designed to replicate, as closely as possible, the original developmental
neurotoxicity study through PND 11 (Appendix N). The effects on maternal and pup
body weights were similar in both studies. For the test substance-treated group in the
follow-up study, DCO were conducted on twice the number of pups per litter and with
additional litters (i.e. two pups per sex per litter from 27 litters) on PND 11. The
observations previously recorded as clonic convulsions or popcorn seizures in this
developmental neurotoxicity study were not observed in any pup in the follow-up study.
The initial observations of clonic movements, observed only at PND 11, were not
considered to be test substance-related because they were not observed in any animals
(including the original six animals) at any other age of evaluation in this developmental
neurotoxicity study and were not reproduced in the follow-up study, which was designed
to further investigate these findings. In addition, these clonic movements were not
considered to be test substance-related because no effects were observed for any other
parameter, including other clinical observations, motor activity, auditory startle response,
learning and memory, macroscopic examinations and measurements, neuropathology, or
brain morphometry.
Page 88 of 4796
8. CONCLUSIONS
There were no test substance-related effects observed in this study at dietary
concentrations of 75 ppm or lower (0.15 and 1.5 ppm). Reductions in mean body weight
and body weight gain were observed in dams and offspring at dietary concentrations of
750 and 2250 ppm. There was no evidence of non-monotonic exposure-response curves
for any parameter. Therefore, the no-observed-adverse-effect level (NOAEL) for
systemic toxicity of BPA was 75 ppm (5.85 mg/kg/day and 13.1 mg/kg/day during
gestation and lactation, respectively).
There was no evidence of developmental neurotoxicity at any dietary concentration.

Thus, the NOAEL for developmental neurotoxicity of BPA was 2250 ppm
(164 mg/kg/day and 410 mg/kg/day during gestation and lactation, respectively), the
highest dietary concentration tested. Based on the conditions of this study, there was no
evidence that BPA is a developmental neurotoxicant in rats.
Page 89 of 4796
9. KEYSTUDYPERSONNEL
ANDREPORT
SUBMISSION
Report Submitted By:
- -
zs&i!zdbaq
Date
Director, Developmental and
Reproductive Toxicology
Study Director
Report Prepared By:
30-Sep-2ooC(
Christian Sfeinfort, BS Date
Senior Study Analyst
Report Reviewed By:
L
Melissa J. Beck, PhD
Assistant Director, Neurosciences
30-s
q -JQq
elyn Tanchevski, BS Date
Group Supervisor, Study Analysis and Reports
Page 90 of 4796
KEY STUDY PERSONNEL AND REPORT SUBMISSION (CONTINUED)

Study Personnel:
Sally A. Keets, AS Senior Operations Manager, Vivarium

Carol A. Kopp, BS, LAT Manager, Gross Pathology and Developmental
Toxicology Laboratory
Theresa M. Rafeld, CPhT Group Manager, Formulations Laboratory
Michael A. Safron, AS,
HT (ASCP)CM Manager, Histology
Daniel W. Sved, PhD Director, Metabolism and Analytical Chemistry
Bennett J. Varsho, MPH, DABT Operations Manager, Developmental and
Reproductive Toxicology and the
Formulations Laboratory
Robert A. Wally, BS, RAC Manager, Reporting and Regulatory Technical
Services
Page 91 of 4796
10. QUALITY ASSURANCE UNIT STATEMENT

10.1. PHASES INSPECTED
Date(s) Date(s)
Findings Findings
Date(s) of Reported to Reported to
Inspection(s) Phase Inspected Study Director Management Auditor(s)
07-Jul-2008 Diet Preparation 07-Jul-2008 22-Aug-2008 L.Weinstock
14-Jul-2008 Diet Administration 14-Jul-2008 22-Aug-2008 P.Rusnak
04-Aug-2008 Diet Preparation 04-Aug-2008 22-Sep-2008 N.Daniels
05-Aug-2008 Test Article Analysis 05-Aug-2008 22-Sep-2008 N.Daniels
22-Aug-2008 Functional Observational

Battery 22-Aug-2008 22-Sep-2008 P.Rusnak
25-Aug-2008 Perfusions 25-Aug-2008 22-Sep-2008 J.Dieterly /

D.Risner
28-Aug-2008 Biel Maze 28-Aug-2008 22-Sep-2008 M.Herrick /

J.Tooman
22-Sep-2008 Trimming of Tissues 22-Sep-2008 24-Oct-2008 P.Rusnak
23-Sep-2008 Perfusions 23-Sep-2008 24-Oct-2008 D.Risner
09-Oct-2008,
10-Oct-2008,
10-Dec-2008 Study Records (I-12) 10-Dec-2008 26-Jan-2009 A.Deppe
15-Oct-2008 Detailed Physicals and Body

Weights 15-Oct-2008 24-Nov-2008 P.Rusnak
15-Oct-2008 Perfusions 15-Oct-2008 24-Nov-2008 J.Dieterly /

D.Risner
17-Oct-2008 Functional Observational

Battery 17-Oct-2008 24-Nov-2008 P.Rusnak
04-Nov-2008 Biel Maze 04-Nov-2008 22-Dec-2008 J.Tooman /

M.Herrick
12-Nov-2008 Trimming of Tissues 12-Nov-2008 22-Dec-2008 P.Rusnak
13-Nov-2008 Perfusions 13-Nov-2008 22-Dec-2008 R.Rohr /

M.Salyers
Page 92 of 4796
Date(s) Date(s)
Findings Findings
15-Nov-2008,
17-Nov-2008,
17-Nov-2008,
18-Nov-2008,
20-Nov-2008,
20-Nov-2008,
21-Nov-2008,
05-Dec-2008,
06-Dec-2008,
08-Dec-2008,
04-Dec-2008,
05-Dec-2008,
06-Jan-2009 Study Records (I-20) 06-Jan-2009 23-Feb-2009 A.Deppe
05-Dec-2008,
06-Dec-2008,
05-Dec-2008,
29-Dec-2008,
30-Dec-2008,
08-Dec-2008,
09-Dec-2008,
10-Dec-2008,
11-Dec-2008,
31-Dec-2008 Study Records (I-1a) 31-Dec-2008 26-Jan-2009 A.Deppe
12-Dec-2008,
13-Dec-2008,
Page 93 of 4796
Date(s) Date(s)
Findings Findings
16-Dec-2008,
19-Dec-2008,
19-Dec-2008,
20-Dec-2008,
16-Dec-2008,
17-Dec-2008,
18-Dec-2008,
19-Dec-2008,
18-Dec-2008,
19-Dec-2008,
18-Dec-2008,
19-Dec-2008,
20-Dec-2008,
20-Dec-2008,
22-Dec-2008,
30-Dec-2008,
31-Dec-2008,
05-Jan-2009 Study Records (Rx-1) 05-Jan-2009 23-Feb-2009 A.Deppe
02-Jan-2009,
05-Jan-2009,
09-Jan-2009 Study Records (N-2) 09-Jan-2009 23-Feb-2009 A.Deppe
05-Jan-2009,
06-Jan-2009,
07-Jan-2009,
09-Jan-2009 Study Records (N-3, N-4, N-5
N-6, N-8) 09-Jan-2009 23-Feb-2009 A.Deppe
Page 94 of 4796
Date(s) Date(s)
Findings Findings
05-Jan-2009,
07-Jan-2009,
16-Jan-2009 Trimming of Tissues, 16-Jan-2009 23-Feb-2009 M.Ninness
27-Feb-2009,
02-Mar-2009,
03-Mar-2009,
04-Mar-2009,
05-Mar-2009 Study Records (A1 through
A-6) 05-Mar-2009 20-Apr-2009 M.Stauffer
27-Feb-2009,
02-Mar-2009,
03-Mar-2009,
04-Mar-2009,
05-Mar-2009,
06-Mar-2009,
13-Mar-2009,
14-Mar-2009,
16-Mar-2009,
17-Mar-2009 Draft Report Tables (without
Neuropathology, Statistical
Analysis and Analytical
Chemistry appendices) 17-Mar-2009 20-Apr-2009 A.Deppe
02-Mar-2009 Statistical Analysis Summary

Report 02-Mar-2009 20-Apr-2009 A.Deppe
06-Mar-2009 Draft Report (Analytical

Chemistry Appendix) 06-Mar-2009 20-Apr-2009 M.Stauffer
11-Jun-2009,
12-Jun-2009 Study Records (H-1) 12-Jun-2009 23-Jul-2009 A.Deppe
11-Jun-2009,
12-Jun-2009 Study Records (P-1) PND 21
Morphometry and Maternal
Liver/Kidneys 12-Jun-2009 23-Jul-2009 A.Deppe
Page 95 of 4796
Date(s) Date(s)
Findings Findings
12-Jun-2009 Study Records (P-1)

Supplemental, including PND
21 Neuropathology 12-Jun-2009 23-Jul-2009 A.Deppe
28-Jul-2009 Study Records (H-3, H-5) 28-Jul-2009 20-Aug-2009 A.Deppe
28-Jul-2009 Study Records (P-2) 28-Jul-2009 20-Aug-2009 A.Deppe
28-Jul-2009,
31-Jul-2009,
03-Aug-2009,
04-Aug-2009,
05-Aug-2009,
06-Aug-2009,
07-Aug-2009,
10-Aug-2009 Draft Report (Text and updated
Tables without Statistical
Analysis, Pathology and
Analytical Chemistry
appendices) 10-Aug-2009 23-Sep-2009 A.Deppe
30-Jul-2009,
31-Jul-2009,
03-Aug-2009,
07-Aug-2009 Pathology Appendix 07-Aug-2009 23-Sep-2009 A.Deppe
12-Aug-2009 Revised Statistical Analysis

Report 12-Aug-2009 23-Sep-2009 A.Deppe
This study was inspected in accordance with the U.S. EPA Good Laboratory Practice
Standards (40 CFR Part 792), the OECD Principles of Good Laboratory Practice, the
standard operating procedures of WIL Research Laboratories, LLC, and the Sponsor's
protocol and protocol amendments with the following exceptions. The data located in
Appendix B (Certificates of Analysis) were the responsibility of the Sponsor and the data
located in Appendix I (Peer Review Statement) were the responsibility of Consultants in
Veterinary Pathology, Inc. Quality Assurance findings, derived from the inspections
during the conduct of the study and from the inspections of the raw data and draft report,
Page 96 of 4796
are documented and have been reported to the Study Director. Review of the protocol
and protocol amendments as well as a yearly internal facility inspection are conducted by
the WIL Quality Assurance Unit. A status report is submitted to management monthly.
This report accurately reflects the data generated during the study. The methods and
procedures used in the study were those specified in the protocol, its amendments, and
the standard operating procedures of WIL Research Laboratories, LLC.
The raw data, the retention sample, and the final report will be stored in the Archives at
WIL Research Laboratories, LLC, or another location specified by the Sponsor.
Page 97 of 4796
10.2. APPROVAL
This study was inspected accorc'ing to h e criteria discussed in Section 10.1.
Report Audited By: A
w -
Alan D. Deppe, BA, RQAP-GLP Date

Project Coordinator, Quality Assurance
compliance Specialist
Report Released By:
Manager, Quality Assurance
Page 98 of 4796
11. REFERENCES
Adams, J.; Buelke-Sam, J.; Kimmel, C.A.; Nelson, C.J.; Reiter, L.W.; Sobotka, T.J.;
Tilson, H.A.; Nelson, B.K. Collaborative behavioral teratology study: protocol
design and testing procedure. Neurobehavioral Toxicology and Teratology 1985, 7,
579-586.
Biel, W.C. Early age differences in maze performance in the albino rat. Journal of
Genetic Psychology 1940, 56, 439-453.
Bodle, E.S. Development and Validation of a GC/NCI-MS Method for the

Determination of Bisphenol A Concentration and Stability in Rodent Diet Admix
Formulations (Study No. WIL-186057). WIL Research Laboratories, LLC,
Ashland, OH, 2009.
Center for the Evaluation of Risks to Human Reproduction (CERHR).

NTP-CERHR Expert Panel Report on the Reproductive and Developmental
Toxicity of Bisphenol A. National Toxicology Program (NTP), U.S. Department of
Health and Human Services (httpt://cerhr.niehs.nih.gov), 2007.
Dunn, O.J. Multiple comparisons using rank sums. Technometrics 1964, 6(3),
241-252.
Dunnett, C.W. New tables for multiple comparisons with a control. Biometrics
1964, 20, 482-491.
Gad, S.C. A neuromuscular screen for use in industrial toxicology. Journal of

Toxicology and Environmental Health 1982, 9, 691-704.
Haggerty, G.C. Development of tier I neurobehavioral testing capabilities for

incorporation into pivotal rodent safety assessment studies. Journal of the American
College of Toxicology. 1989, 8(1), 53-69.
Holson, R.; Freshwater, L.; Maurissen, P. J.; Moser, V. C.; Phang, W. Statistical
issues and techniques appropriate for developmental neurotoxicity testing: a report
from the ILSI Research Foundation/Risk Science Institute expert working group on
neurodevelopmental endpoints. Neurotoxicology and teratology 2007, 30(4),
326-48.
Irwin, S.C. Comprehensive observational assessment: Ia. A systematic quantitative

procedure for assessing the behavioral physiological state of the mouse.
Psychopharmacologia 1968, 13, 222-256.
Page 99 of 4796
Korenbrot, C.C.; Huhtaniemi, I.T.; Weiner, R.I. Preputial separation as an external

sign of pubertal development in the male rat. Biology of Reproduction 1977, 17,
298-303.
Kruskal, W.H.; Wallis, W.A. Use of ranks in one-criterion variance analysis.

Journal of the American Statistical Association 1952, 47, 583-621.
Moser, V.C.; McCormick, J.P.; Creason, J.P.; MacPhail, R.C. Comparison of

chlordimeform and carbaryl using a functional observational battery. Fundamental
and Applied Toxicology 1988, 11, 189-206.
Moser, V.C.; McDaniel, K.L.; Phillips, P.M. Rat strain and stock comparisons using
a functional observational battery: Baseline values and effects of Amitraz.
Toxicology and Applied Pharmacology 1991, 108, 267-283.
National Research Council. Guide for the Care and Use of Laboratory Animals,
Institute of Laboratory Animal Resources, Commission on Life Sciences; National
Academy Press: Washington, DC, 1996.
ODonoghue, J.L. Screening for neurotoxicity using a neurologically based

examination and neuropathology. Journal of the American College of Toxicology
1989, 8(1), 97-115.
Paxinos, G.; Watson, C. The Rat Brain in Stereotaxic Coordinates, Fourth Edition.
Academic Press: New York, NY, 1998.
Salewski, E. Frbemethode zum makroskopischen Nachweis von

Implantationsstellen am Uterus der Ratte. [Staining method for a macroscopic test
for implantation sites in the uterus of the rat]. Naunyn - Schmiedebergs Archiv fr
Experimentelle Pathologie und Pharmakologie 1964, 247, 367.
Steel, R.G.D.; Torrie, J.H. Principles and Procedures of Statistics, A Biometrical

Approach, 2nd ed.; McGraw-Hill Book Company: New York, NY, 1980;
pp 504-506.
Stuckhardt, J.L.; Poppe, S.M. Fresh visceral examination of rat and rabbit fetuses
used in teratogenicity testing. Teratogenesis, Carcinogenesis and Mutagenesis
1984, 4, 181-188.
Stump, D.G. A Dietary Dose Range-Finding Developmental Neurotoxicity Study of

Bisphenol A in Rats (Study No. WIL-186055). WIL Research Laboratories, LLC,
Ashland, OH, 2009.
Page 100 of 4796

Stump, D.G. A Dietary Study of Bisphenol A in Rats to Re-evaluate Pup

Observations from a Developmental Neurotoxicity Study (Study No. WIL-186058).
WIL Research Laboratories, LLC, Ashland, OH, 2009.
Page 101 of 4796

12. DEVIATIONS FROM THE PROTOCOL

This study was conducted in accordance with the protocol and protocol amendments,
except for the following.
Protocol Section 4.6 states that the test substance would be stored at room
temperature, protected from light, and desiccated. Prior to the initiation of the study,
the test substance was stored without desiccation from 5 December 2007 to
22 January 2008. In addition, 2 samples of the test substance used for calibration and
quality control stock solutions were received in amber bottles from the formulations
department; however, protection from light was not documented.
Protocol Section 5.5 states that animals would have a body weight of at least 220 g at
the initiation of the breeding period. Female no. 23265 had a body weight of 218 g
on 13 July 2008 and was paired with a male on 15 July 2008. The female was
unpaired on 17 July 2008 without evidence of mating and was not placed on study.
Protocol Section 6.1 states that females would be transferred to polyphenylsulfone

RaTEMP thermoplastic rat cages (Allentown Inc., Allentown, NJ) with nesting
material on gestation day 18 and the animals would remain in these cages until
euthanasia. The transfer of the animals into litter boxes at the appropriate age was
documented; however, the specific litter box type was not documented.
Protocol Section 6.2 states that fluorescent lighting would provide illumination for a
12-hour light (0600 hours to 0600 hours)/dark photoperiod. The 12-hour light
photoperiod was interrupted for approximately 28 minutes for animals receiving a
PND 60 detailed clinical observation on 6 October 2008. On the morning of
30 October 2008, the light photoperiod was interrupted for approximately 15 minutes
(0615 hours to 0630 hours) due to a power outage. In addition, the 12-hour light
photoperiod was interrupted for approximately 34 minutes for animals receiving a
motor activity assessment on 5 November 2008.
Protocol Section 6.4 states that a single lot of diet would be used for the entire study.
The single lot selected for use throughout the study was lot no. JUN03082C.
However, during the first day of the mating period (13-14 July 2008) for Cohort 1,
males and females were offered the basal diet from lot no. APR09082C. In addition,
the lot of diet used was not documented during 1-16 July 2008.
Protocol Section 7.7.2 states that all dams would be examined for detailed clinical
observations on gestation days 10 and 15 and lactation days 10 and 21. Female
no. 26505 in the 0.15 ppm group was not examined for detailed clinical observations
on gestation day 10.
Protocol Section 7.8.1 states that individual pup body weights would be recorded
whenever they are removed from their cages for behavioral testing. The appropriate
Page 102 of 4796

body weights were not recorded for PND 4 animals receiving a detailed clinical
observation on 8 August 2008; however, the scheduled PND 4 body weights were
collected for these animals. Additionally, the appropriate weight was not collected
for female nos. 23261-10 and 23264-13 in the 0.15 ppm group and female
no. 23260-11 in the 1.5 ppm group prior to the PND 21 detailed clinical observations;
however, the scheduled PND 21 body weights were collected for these animals.
Protocol Section 7.9.3 states that all pups would be examined for surface righting
reflex beginning on PND 2 and would continue to be evaluated until attainment of the
criterion or until the pup was selected for culling and did not have a positive response
by PND 4. Pup no. 23248-09 (1.5 ppm group) was not examined for surface righting
reflex on PND 11; this animal exhibited a negative response on PND 10 and a
positive response on PND 12.
Protocol Section 7.10.1 states that the same animals would be evaluated for detailed
clinical observations on PND 4, 11, 21, 35, 45, and 60. Female nos. 23207-10,
23244-11, and 23257-16 in the 0, 1.5 and 2250 ppm groups, respectively, received
detailed clinical observations on PND 4 and were found dead or missing prior to the
PND 11 evaluation. As a result, these same respective animals were replaced on
study by female nos. 23207-14, 23244-17, and 23257-11, respectively, for subsequent
evaluations. Male no. 23244-01 in the 1.5 ppm group received detailed clinical
observations on PND 4 and 11 and was found dead on PND 13. As a result, this
animal was replaced on study by male no. 23244-04 for subsequent evaluations.
Protocol Section 7.10.2 states that motor activity would be evaluated for
1 pup/sex/litter (animals assigned to Subset A) on PND 13, 17, 21, and 61. Motor
activity counts were not recorded as scheduled for female no. 26514-14 in the
1.5 ppm group on PND 17 due to an equipment malfunction.
Protocol Section 7.10.4 states that the minimum intertrial interval would be 1 hour
for learning and memory evaluation. The time that male no. 23203-08 in the control
group was placed in the Biel Maze was not recorded for Trial 12 of the PND 22
learning and memory evaluation; therefore, it was not possible to confirm that the
animal rested for 1 hour between trials. However, the animals evaluated before
(no. 23203-13) and after (no. 23201-04) this male both received at least 1 hour of rest
between trials.
Protocol Section 7.10.4 states that the time to escape and number of errors in the Biel
maze would be recorded. The time to escape for male no. 23217-04 in the 1.5 ppm
group was not recorded appropriately for Trial 12 on PND 28. The time to escape for
male no. 26479-03 in the 0.15 ppm group was not recorded for Trial 4 on PND 64.
Additionally, the number of errors was not recorded for female no. 23247-13 in the
750 ppm group for Trial 8 on PND 67.
Page 103 of 4796

Protocol Section 8.1.1 states that the number and location of former implantation
sites would be recorded. The number of former implantation sites was not recorded
for female no. 26481 in the 750 ppm group.
Protocol Section 8.1.6 states that the liver and kidneys would be examined
microscopically for all maternal animals. In addition to the protocol-required tissues,
gross lesions from female nos. 23210 (thymus) and 23184 (stomach) in the 75 ppm
group and female no. 23234 (diaphragm and ureters) in the 2250 ppm group were
processed to slide and examined microscopically.
Protocol Section 8.3.1.2 and 8.4.2 state that neuropathological examinations would
be performed on 1 pup/litter (10 pups/sex) from all groups and any pups that showed
potential exposure-related effects on neurobehavioral observations or measurements.
In addition to the protocol-required examinations, the brain of an additional female
pup (no. 26534-08) in the 1.5 ppm group was microscopically examined on PND 21
and the brain from an additional male pup (no. 26492-03) in the 0.15 ppm group was
microscopically examined on PND 72 due to macroscopic findings. As only limited
tissues were examined for these two animals, the microscopic data for these animals
was not included on the summary tables but are presented on the individual animal
data tables.
Protocol Section 8.3.1.2 and 8.4.2 state that a neuropathological examination would
be performed on any pup not selected in the original 10 pups/sex/group that showed
potential treatment-related effects on neurobehavioral observations or measurements.
The protocol specified that the histopathological examination would include a simple
morphometric analysis. Although a neuropathology examination was performed on
all six pups observed with clonic movements, brain morphometry measurements were
not recorded for four of these pups (male no. 23223-08 in the 750 ppm group and
female nos. 23211-11, 23234-08, and 26465-12 in the 2250 ppm group) because the
tissue sections for PND 72 morphometry for these animals were generally not
adequate for measurement of all levels.
Protocol Section 8.4.1 states that animals on PND 72 would be anesthetized by an

intraperitoneal injection of sodium pentobarbital and euthanized by perfusion. There
is no documentation of the route of administration of sodium pentobarbital for
PND 72 animals euthanized on 14 November 2008.
Protocol Section 8.4.1 states that after perfusion, the nervous system tissues would
be retained for all animals and the central and peripheral nervous system tissues from
all animals would be dissected and preserved in 10% neutral-buffered formalin; the
brains were to be retained following measurements. The heads for all animals
perfused on 15 and 16 October 2008 (6, 4, 6, 2, 4, and 2 animals in the control, 0.15,
1.5, 75, 750, and 2250 groups, respectively) were not retained after measurement;
therefore, the eyes, optic nerves, and trigeminal nerves were not retained for these
animals.
Page 104 of 4796

Protocol Section 8.4.2 states that specific brain morphometry measurements would
be conducted according to WIL Research Laboratories, LLCs standard operating
procedures. However, the first measurement on Level 5 was changed to the height of
the cerebellum perpendicular to the brainstem from the heel of the Purkinje cell layer
of lobule 10 at a scale of 1:2. Additionally, a scale of 1:1 was used for measuring the
cortex thickness of Level 1 at the apex of the cingulum, and a scale of 3:1 was used
for the first measurement on Level 1 due to the size of the images.
Protocol Section 8.4.2 states the specific tissues to be examined microscopically. In

addition to the protocol-specified tissues, the cervical and lumbar spinal nerves were
examined for all animals; findings were only to be tabulated on the report tables if
there was an abnormality present. However, the lumbar spinal nerve was recorded as
being examined for male no. 26452-02 in the control group despite having no
abnormalities present.
Protocol Section 8.5 states that the pathology peer review of the microscopic
evaluation of brains would be conducted on 50% of the selected PND 21 animals
(5/sex/group). However, all male rats from the control and 2250 ppm groups
(10/group) were evaluated by the peer review pathologist.
These deviations did not negatively impact the quality or integrity of the data or the
outcome of the study.
Page 105 of 4796

FIGURES 1 - 30
Page 106 of 4796

PROJECT NO.:WIL-186056 FIGURE 1 (F0 FEMALES)
SPONSOR:ACC SUMMARY OF BODY WEIGHTS DURING GESTATION [G]
450
400
*
MEAN BODY WEIGHT [G] (SE)
*
350
*
Page 107 of 4796
*
*
300
* *
* *
* *
250
*
200
150
0 3 7 10 14 17 20
GESTATION DAY
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
* = Significantly different from the control group at 0.05 using Dunnett's test
BW v1.00 02/11/2009
SPONSOR:ACC SUMMARY OF BODY WEIGHTS DURING LACTATION [G]
380
360
340
* *
320
*
*
Page 108 of 4796
*
300
*
*
280
*
260
240
220
200
1 4 7 11 14 17 21
LACTATION DAY
BW v1.00 02/12/2009
SPONSOR:ACC SUMMARY OF TEST SUBSTANCE CONSUMPTION DURING GESTATION [MG/KG/DAY]
TEST SUBSTANCE CONSUMPTION [MG/KG/DAY] (SE)
1000
100
10
Page 109 of 4796
0.1
0.01
0.001
GESTATION DAYS 0-20
SPONSOR:ACC SUMMARY OF TEST SUBSTANCE CONSUMPTION DURING LACTATION [MG/KG/DAY]
1000
TEST SUBSTANCE CONSUMPTION [MG/KG/DAY] (SE)
100
10
Page 110 of 4796
0.1
0.01
0.001
LACTATION DAYS 1-21
PROJECT NO.:WIL-186056 FIGURE 5 (F1 MALES)
SPONSOR:ACC SUMMARY OF OFFSPRING WEIGHTS [G]
60
*
*
50
*
40
**
Page 111 of 4796
30 **
*
*
20
*
* *
10
0
1 4 (pre- 4 (post- 7 11 14 17 21
culling) culling)
POSTNATAL DAY
BW v1.00 02/12/2009
60
50
40
*
Page 112 of 4796
30 *
*
*
20
*
10
*
0
1 4 (pre- 4 (post- 7 11 14 17 21
culling) culling)
POSTNATAL DAY
BW v1.00 02/12/2009
PROJECT NO.:WIL-186056A FIGURE 7 (F1 MALES)
SPONSOR:ACC SUMMARY OF POST-WEANING BODY WEIGHTS [G]
500
450
400
350
300
Page 113 of 4796
250
200
150
100
50
0
28 35 42 49 56 63 70
POSTNATAL DAY
BW v1.00 02/12/2009
PROJECT NO.:WIL-186056D FIGURE 8 (F1 FEMALES)
SPONSOR:ACC SUMMARY OF POST-WEANING BODY WEIGHTS [G]
300
250
200
Page 114 of 4796
150
100
50
0
28 35 42 49 56 63 70
POSTNATAL DAY
BW v1.00 02/12/2009
PROJECT NO.:WIL-186056S FIGURE 9 (F1 COMBINED SEXES - PND 13, 17, AND 21)
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY TOTAL COUNTS BY SESSION
4500
4000
3500
TOTAL COUNTS IN SESSION (SE)
3000
Page 115 of 4796
2500
2000
1500
1000
500
0
PND 13 PND 17 PND 21
PROJECT NO.:WIL-186056S FIGURE 10 (F1 COMBINED SEXES - PND 13)
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY TOTAL COUNTS
700
600
500
MEAN TOTAL COUNTS (SE)
Page 116 of 4796
400
300
200
100
0
0-10 11-20 21-30 31-40 41-50 51-60
TIME (MINUTES)
1600
1400
1200
1000
Page 117 of 4796
800
600
400
200
0
0-10 11-20 21-30 31-40 41-50 51-60
TIME (MINUTES)
1800
1600
1400
1200
Page 118 of 4796
1000
800
600
400
200
0
0-10 11-20 21-30 31-40 41-50 51-60
TIME (MINUTES)
PROJECT NO.:WIL-186056S FIGURE 13 (F1 MALES - PND 61)
7000
6000
5000
Page 119 of 4796
4000
3000
2000
1000
0
MALES
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PM 2250 PPM

PROJECT NO.:WIL-186056S FIGURE 14 (F1 FEMALES - PND 61)
7000
6000
5000
Page 120 of 4796
4000
3000
2000
1000
0
FEMALES
0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PM 2250 PPM

1800
1600
1400
1200
Page 121 of 4796
1000
800
600
400
200
0
0-10 11-20 21-30 31-40 41-50 51-60
TIME (MINUTES)
2500
2000
Page 122 of 4796
1500
1000
500
0
0-10 11-20 21-30 31-40 41-50 51-60
TIME (MINUTES)
SPONSOR:ACC SUMMARY OF STARTLE RESPONSE DATA [MAX]
2.5
MAX [NEWTONS] (SE)
2
Page 123 of 4796
1.5
0.5
0
0-10 11-20 21-30 31-40 41-50
TIME (MINUTES)
SPONSOR:ACC SUMMARY OF STARTLE RESPONSE DATA [MAX]
3.5
3
MAX [NEWTONS] (SE)
2.5
Page 124 of 4796
1.5
0.5
0
0-10 11-20 21-30 31-40 41-50
TIME (MINUTES)
PROJECT NO.:WIL-186056W FIGURE 19 (F1 COMBINED SEXES - PND 22)
SPONSOR:ACC SUMMARY OF BIEL MAZE DATA - MEAN NO. OF ERRORS
40
35
30
MEAN NO. OF ERRORS (SE)
25
Page 125 of 4796
20
15
10
0
1 2 3 4 5 6 7 8 9 10 11 12
PATH A PATH B PATH A
TRIAL
PROJECT NO.:WIL-186056W FIGURE 20 (F1 MALES - PND 22)
45
40
35
30
Page 126 of 4796
25
20
15
10
0
1 2 3 4 5 6 7 8 9 10 11 12
TRIAL
PROJECT NO.:WIL-186056W FIGURE 21 (F1 FEMALES - PND 22)
45
40
35
30
Page 127 of 4796
25
20
15
10
0
1 2 3 4 5 6 7 8 9 10 11 12
TRIAL
35
30
25
Page 128 of 4796
20
*
15
10
0
1 2 3 4 5 6 7 8 9 10 11 12
TRIAL
35
30
25
Page 129 of 4796
20
15
10
0
1 2 3 4 5 6 7 8 9 10 11 12
TRIAL
40
35
30
25
Page 130 of 4796
20
15
10
0
1 2 3 4 5 6 7 8 9 10 11 12
TRIAL
PROJECT NO.:WIL-186056U FIGURE 25 (F1 COMBINED SEXES - PND 21)
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [LEVEL 1]
0.8
0.7
0.6
CENTIMETERS (SE)
0.5
Page 131 of 4796
0.4
0.3
0.2
0.1
0
HT HEMISPHERE V THICKNESS CORTEX
HT = HEIGHT V = VERTICAL
0.18
0.16
0.14
0.12
CENTIMETERS (SE)
Page 132 of 4796
0.1
0.08
0.06
0.04
0.02
0
RADIAL THICKNESS CORTEX V HT BTW HIPPOCAMPAL V HT DENTATE HILUS LENGTH VENTRAL LIMB
PYRAMIDAL NEURON LAYERS DENTATE HILUS
HT = HEIGHT V = VERTICAL BTW = BETWEEN
0.6
0.5
0.4
CENTIMETERS (SE)
Page 133 of 4796
0.3
0.2
0.1
0
V HEIGHT OF THE CEREBELLUM BASE OF LOBULE 9
V = VERTICAL
0.8
0.7
0.6
CENTIMETERS (SE)
0.5
Page 134 of 4796
0.4
0.3
0.2
0.1
0
HT HEMISPHERE V THICKNESS CORTEX
HT = HEIGHT V = VERTICAL
0.2
0.18
0.16
0.14
CENTIMETERS (SE)
0.12
Page 135 of 4796
0.1
0.08
0.06
0.04
0.02
0
RADIAL THICKNESS CORTEX V HT BTW HIPPOCAMPAL V HT DENTATE HILUS LENGTH VENTRAL LIMB
PYRAMIDAL NEURON LAYERS DENTATE HILUS
HT = HEIGHT V = VERTICAL BTW = BETWEEN
0.6
0.5
0.4
CENTIMETERS (SE)
Page 136 of 4796
0.3
0.2
0.1
0
V HEIGHT OF THE CEREBELLUM BASE OF LOBULE 9
V = VERTICAL
TABLES 1 -44
Page 137 of 4796

TABLE 1 (F0)
PROJECT NO.:WIL-186056 DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF MATERNAL SURVIVAL AND PREGNANCY STATUS
-----------------------------------------------------------------------------------------------------------------------------------
DOSE GROUP : 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NO. % NO. % NO. % NO. % NO. % NO. %
FEMALES ON STUDY 24 24 24 24 24 24
FEMALES THAT DIED 0 0 0 0 0 1-A
FEMALES THAT WERE EUTH. IN EXTREMIS 0 0 0 0 0 0
FEMALES SCHEDULED TO DELIVER 24 24 24 24 24 24

NONGRAVID 1 4.2 1 4.2 0 0.0 0 0.0 0 0.0 0 0.0
GRAVID 23 95.8 23 95.8 24 100.0 24 100.0 24 100.0 24 100.0
NO. THAT FAILED TO DELIVER 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0
NO. WITH TOTAL LITTER LOSS 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0
NO. WITH VIABLE PUPS 23 100.0 23 100.0 24 100.0 24 100.0 24 100.0 24 100.0
Page 138 of 4796
TOTAL FEMALES GRAVID 23 95.8 23 95.8 24 100.0 24 100.0 24 100.0 24 100.0

-----------------------------------------------------------------------------------------------------------------------------------
1- 0 PPM 2- 0.15 PPM 3- 1.5 PPM 4- 75 PPM 5- 750 PPM 6- 2250 PPM
A = FEMALE NO. 23237 WAS FOUND DEAD ON LACTATION DAY 0; INCLUDED IN CALCULATIONS.
MANUALv1.0
12/17/2008
R:12/17/2008
TABLE 2 (F0 - DAILY EXAMINATIONS)
SPONSOR:ACC SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS
----- F E M A L E -----
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NORMAL
-NO SIGNIFICANT CLINICAL OBSERVATIONS 967/24 832/23 904/24 878/24 894/24 855/24
DISPOSITION
-FOUND DEAD 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1
-SCHEDULED EUTHANASIA; POST-MATING DAY 25 1/ 1 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0
-SENT TO NECROPSY; SEX RATIO CRITERIA 0/ 0 0/ 0 0/ 0 2/ 2 2/ 2 0/ 0
NOT MET
-SCHEDULED EUTHANASIA; LACTATION DAY 21 23/23 23/23 24/24 22/22 22/22 23/23
BEHAVIOR/CNS
Page 139 of 4796
-BODY FLATTENED 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0
BODY/INTEGUMENT
-HAIR LOSS RIGHT FORELIMB 59/ 5 193/ 9 127/ 5 118/ 5 88/ 4 77/ 5
-HAIR LOSS LEFT FORELIMB 49/ 4 190/ 8 120/ 5 127/ 6 97/ 4 71/ 5
-HAIR LOSS RIGHT HINDLIMB 0/ 0 0/ 0 0/ 0 0/ 0 17/ 1 107/ 3
-HAIR LOSS LEFT HINDLIMB 0/ 0 0/ 0 0/ 0 0/ 0 15/ 1 97/ 3
-HAIR LOSS RUMP 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 72/ 3
-HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 54/ 3
-HAIR LOSS VENTRAL ABDOMINAL AREA 1/ 1 0/ 0 9/ 1 0/ 0 0/ 0 75/ 3
-HAIR LOSS LEFT LATERAL ABDOMINAL AREA 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 40/ 3
-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
BODY/INTEGUMENT
-HAIR LOSS RIGHT INGUINAL AREA 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 35/ 3
-HAIR LOSS LEFT INGUINAL AREA 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 29/ 1
-HAIR LOSS VENTRAL THORACIC AREA 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0 3/ 2
-HAIR LOSS RIGHT LATERAL THORACIC AREA 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 4/ 1
-HAIR LOSS UROGENITAL AREA 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 15/ 2
-SCABBING LEFT FORELIMB 0/ 0 0/ 0 0/ 0 1/ 1 1/ 1 0/ 0
-SCABBING VENTRAL ABDOMINAL AREA 0/ 0 0/ 0 5/ 1 4/ 1 0/ 0 0/ 0
-SCABBING RIGHT FORELIMB 0/ 0 0/ 0 11/ 1 2/ 1 0/ 0 0/ 0
-WET RED MATERIAL UROGENITAL AREA 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0
Page 140 of 4796
CARDIO-PULMONARY
-INCREASED RESPIRATION 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0
EYES/EARS/NOSE
-DRIED RED MATERIAL AROUND NOSE 1/ 1 1/ 1 2/ 2 2/ 1 5/ 3 9/ 5
-DRIED RED MATERIAL AROUND RIGHT EYE 0/ 0 1/ 1 0/ 0 5/ 1 0/ 0 0/ 0
-WET RED MATERIAL AROUND NOSE 0/ 0 0/ 0 1/ 1 1/ 1 0/ 0 0/ 0
-DRIED RED MATERIAL AROUND LEFT EYE 0/ 0 0/ 0 3/ 1 0/ 0 0/ 0 0/ 0
EXCRETA
-DECREASED DEFECATION 0/ 0 0/ 0 0/ 0 0/ 0 4/ 2 1/ 1
-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
EXCRETA
-WET RED VAGINAL DISCHARGE 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1
ORAL/DENTAL
-WET RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 0/ 0 2/ 2 0/ 0
-----------------------------------------------------------------------------------------------------------------------------------
PCSUv4.07
12/16/2008
Page 141 of 4796
TABLE 3 (F0 - GESTATION)
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS GD 10
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS TESTED 23 22 24 24 24 24
GENERAL BODY POSTURE

SITTING/STANDING NORMALLY 12 15 18 16 18 14
ASLEEP 7 6 5 5 4 8
ALERT 4 1 1 3 2 2
EASE OF REMOVAL FROM CAGE

VERY EASY 23 20 23 22 20 21
EASY - 2 1 2 4 3
WITH VOCALIZATION - 2 1 1 2 1
WITHOUT VOCALIZATION - - - 1 2 2
Page 142 of 4796
EASE OF HANDLING ANIMAL IN HAND

LOW 23 20 22 22 22 23
MODERATELY LOW - 2 2 2 2 1
WITHOUT VOCALIZATION - 2 2 1 2 1
- - - 1 - -
LACRIMATION
NONE 23 22 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
DATA PRESENTED ARE NUMBER OF ANIMALS EXHIBITING RESPONSE, UNLESS OTHERWISE NOTED
GD= GESTATIONAL DAY
None significantly different from control group
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
CHROMODACRYORRHEA
ABSENT 23 22 24 24 24 24
SALIVATION
NONE 23 22 24 24 24 24
PILOERECTION
NONE 23 22 24 24 24 24
FUR APPEARANCE
NORMAL: CLEAN AND GROOMED 23 22 24 24 24 24
Page 143 of 4796
PALPEBRAL CLOSURE
EYELIDS WIDE OPEN 23 22 24 24 24 24
RESPIRATORY RATE
NORMAL (80-110) 23 22 24 24 24 24
RESPIRATORY CHARACTER
NORMAL 23 22 24 24 24 24
RED DEPOSITS - EYES

PRESENT 1 - - - 1 -
ABSENT 22 22 24 24 23 24
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
RED DEPOSITS - NOSE

PRESENT 2 1 3 1 3 3
ABSENT 21 21 21 23 21 21
RED DEPOSITS - MOUTH

ABSENT 23 22 24 24 24 24
CRUSTY DEPOSITS - EYES

ABSENT 23 22 24 24 24 24
CRUSTY DEPOSITS - NOSE

Page 144 of 4796
ABSENT 23 22 24 24 24 24
CRUSTY DEPOSITS - MOUTH

ABSENT 23 22 24 24 24 24
MUCOUS MEMBRANES - COLOR

PINK 23 22 24 24 24 24
EYE COLOR
PINK 23 22 24 24 24 24
SKIN COLOR
PINK 23 22 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
EYE PROMINENCE
NORMAL 23 22 24 24 24 24
MUSCLE TONE
FIRM BUT NOT HARD 23 22 24 24 24 24
MOBILITY
NORMAL 23 22 24 24 24 24
GAIT
NORMAL 23 22 24 24 24 24
Page 145 of 4796
CONVULSIONS-CLONIC
ABSENT 23 22 24 24 24 24
CONVULSIONS-TONIC
ABSENT 23 22 24 24 24 24
TREMORS
NONE 23 22 24 24 24 24
AROUSAL
NORMAL 23 22 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
BIZARRE/STEREOTYPIC BEHAVIOR
NONE 23 22 24 24 24 24
PUPILLARY RESPONSE
PRESENT 23 22 24 24 24 24
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 22 24 24 24 24
GROOMING COUNTS
Page 146 of 4796
MEAN 0.0 0.0 0.0 0.1 0.2 0.1

S.D. 0.21 0.21 0.20 0.28 0.48 0.28
N 23 22 24 24 24 24
URINATION COUNTS
MEAN 0.3 0.4 0.3 0.3 0.3 0.3
S.D. 0.49 0.50 0.69 0.55 0.69 0.53
N 23 22 24 24 24 24
DEFECATION COUNTS
MEAN 0.3 0.3 0.2 0.7 0.5 0.7
S.D. 0.76 0.77 0.66 1.40 1.38 2.12
N 23 22 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ASLEEP 4 7 5 1 4 6
ALERT 3 2 2 4 4 1
REARING - - - - - 1

VERY EASY 22 19 21 24 21 19
EASY 1 4 3 - 3 5
WITH VOCALIZATION 1 3 2 - 1 2
WITHOUT VOCALIZATION - 1 1 - 2 3
Page 147 of 4796

LOW 23 19 22 22 22 19
MODERATELY LOW - 4 2 2 2 5
WITH VOCALIZATION - 2 1 1 - 1
WITHOUT VOCALIZATION - 2 1 1 2 4
LACRIMATION
NONE 23 23 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
CHROMODACRYORRHEA
ABSENT 23 23 24 24 24 24
SALIVATION
NONE 23 23 24 24 24 24
PILOERECTION
NONE 23 23 24 24 24 24
FUR APPEARANCE
Page 148 of 4796
PALPEBRAL CLOSURE
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 24 24 24
NORMAL 23 23 24 24 24 24
RED DEPOSITS - EYES

PRESENT 1 - 2 - 1 -
ABSENT 22 23 22 24 23 24
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
RED DEPOSITS - NOSE

PRESENT 3 1 3 5 4 3
ABSENT 20 22 21 19 20 21

ABSENT 23 23 24 24 24 24

ABSENT 23 23 24 24 24 24

Page 149 of 4796
ABSENT 23 23 24 24 24 24

ABSENT 23 23 24 24 24 24

PINK 23 23 24 24 24 24
EYE COLOR
PINK 23 23 24 24 24 24
SKIN COLOR
PINK 23 23 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
EYE PROMINENCE
NORMAL 23 23 24 24 24 24
MUSCLE TONE
MOBILITY
NORMAL 23 23 24 24 24 24
GAIT
NORMAL 23 23 24 24 24 24
Page 150 of 4796
CONVULSIONS-CLONIC
ABSENT 23 23 24 24 24 24
CONVULSIONS-TONIC
ABSENT 23 23 24 24 24 24
TREMORS
NONE 23 23 24 24 24 24
AROUSAL
NORMAL 23 23 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NONE 23 23 24 24 24 24
PUPILLARY RESPONSE
PRESENT 23 23 24 24 24 24
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 24 24 24
GROOMING COUNTS
Page 151 of 4796
MEAN 0.1 0.0 0.2 0.3 0.1 0.0

S.D. 0.29 0.21 0.38 0.92 0.34 0.20
N 23 23 24 24 24 24
URINATION COUNTS
MEAN 0.3 0.2 0.3 0.3 0.1 0.2
S.D. 0.56 0.52 0.62 0.61 0.28 0.38
N 23 23 24 24 24 24
DEFECATION COUNTS
MEAN 0.5 0.6 0.3 0.4 0.3 0.2
S.D. 1.53 1.23 0.74 1.35 0.85 0.66
N 23 23 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
PFOBGv1.52
01/12/2009
R:01/12/2009
TABLE 4 (F0 - LACTATION)
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS LD 10
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ASLEEP 2 3 1 3 1 2
ALERT 4 3 5 3 3 4
REARING 1 1 2 - 1 2

VERY EASY 22 22 23 20 21 19
EASY 1 1 1 2 - 4
WITH VOCALIZATION - - - - - 3
WITHOUT VOCALIZATION 1 1 1 2 - 1
Page 152 of 4796
MODERATELY DIFFICULT - - - - 1 -
WITH VOCALIZATION - - - - 1 -
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

LOW 20 21 24 22 22 22
MODERATELY LOW 3 1 - - - 1
WITH VOCALIZATION 1 - - - - -
WITHOUT VOCALIZATION 2 1 - - - 1
MODERATELY HIGH - 1 - - - -
WITHOUT VOCALIZATION - 1 - - - -
LACRIMATION
NONE 23 23 24 21 22 22
SLIGHT - - - 1 - 1
Page 153 of 4796
CHROMODACRYORRHEA
ABSENT 23 23 24 22 22 23
SALIVATION
NONE 23 23 24 22 22 23
PILOERECTION
NONE 23 23 24 22 22 23
FUR APPEARANCE
SLIGHTLY SOILED - - - - - 1
PALPEBRAL CLOSURE
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 22 23
NORMAL 23 23 24 22 22 23
RED DEPOSITS - EYES

ABSENT 23 23 24 22 22 23
RED DEPOSITS - NOSE

PRESENT - - - 1 4+ -
Page 154 of 4796
ABSENT 23 23 24 21 18+ 23

ABSENT 23 23 24 22 22 23

ABSENT 23 23 24 22 22 23

PRESENT 1 - 3 1 - 3
ABSENT 22 23 21 21 22 20
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
+ = Significantly different from the control group at 0.05 using Fisher's Exact test
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

PRESENT 1 - - - - -
ABSENT 22 23 24 22 22 23

PINK 23 23 24 22 22 23
EYE COLOR
PINK 23 23 24 22 22 23
SKIN COLOR
Page 155 of 4796
PINK 23 23 24 22 22 23
EYE PROMINENCE
NORMAL 23 23 24 22 22 23
MUSCLE TONE
MOBILITY
NORMAL 23 23 24 22 22 23
GAIT
NORMAL 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 22 23
CONVULSIONS-TONIC
ABSENT 23 23 24 22 22 23
TREMORS
NONE 23 23 24 22 22 23
AROUSAL
NORMAL 23 23 24 22 22 23
Page 156 of 4796
NONE 23 23 24 22 22 23
PUPILLARY RESPONSE
PRESENT 23 23 24 22 22 23
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 22 23
GROOMING COUNTS
MEAN 0.0 0.3 0.2 0.1 0.2 0.0
S.D. 0.00 0.54 0.64 0.43 0.53 0.00
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
URINATION COUNTS
MEAN 0.3 0.2 0.3 0.5 0.4 0.2
S.D. 0.49 0.49 0.53 0.60 0.58 0.42
N 23 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.4 0.4 0.7 0.7 0.8 0.7
S.D. 0.90 0.99 1.46 1.24 1.97 1.54
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
Page 157 of 4796
LD= LACTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ASLEEP - 1 3 3 - -
ALERT 2 3 4 5 2 2
REARING 3 1 1 - 3 2

VERY EASY 20 19 23 16 19 20
EASY 3 4 1 6 3 3
WITH VOCALIZATION - - - 2 - 1
WITHOUT VOCALIZATION 3 4 1 4 3 2
Page 158 of 4796

LOW 21 20 22 19 19 20
MODERATELY LOW 2 3 2 3 3 3
WITH VOCALIZATION - - - - 1 2
WITHOUT VOCALIZATION 2 3 2 3 2 1
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION
NONE 23 23 23 21 22 23
SLIGHT - - 1 1 - -
CHROMODACRYORRHEA
ABSENT 23 23 24 22 22 23
SALIVATION
NONE 23 23 24 22 22 23
PILOERECTION
NONE 23 23 24 22 22 23
Page 159 of 4796
FUR APPEARANCE
SLIGHTLY SOILED - - - - 2 -
PALPEBRAL CLOSURE
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 22 23
NORMAL 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
RED DEPOSITS - EYES

PRESENT - 1 1 - - -
ABSENT 23 22 23 22 22 23
RED DEPOSITS - NOSE

PRESENT 5 2 2 1 3 1
ABSENT 18 21 22 21 19 22

ABSENT 23 23 24 22 22 23
Page 160 of 4796

ABSENT 23 23 24 22 22 23

PRESENT 1 - 2 1 2 1
ABSENT 22 23 22 21 20 22

ABSENT 23 23 24 22 22 23

PINK 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
EYE COLOR
PINK 23 23 24 22 22 23
SKIN COLOR
PINK 23 23 24 22 22 23
EYE PROMINENCE
NORMAL 23 23 24 22 22 23
MUSCLE TONE
Page 161 of 4796
MOBILITY
NORMAL 23 23 24 22 22 23
GAIT
NORMAL 23 23 24 22 22 23
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 22 23
CONVULSIONS-TONIC
ABSENT 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
TREMORS
NONE 22 23 24 22 22 23
SLIGHT (1.5MM) 1 - - - - -
AROUSAL
LOW 1 - - - - 1
NORMAL 22 23 24 22 22 22
NONE 23 23 24 22 22 23
Page 162 of 4796
PUPILLARY RESPONSE
ABSENT - 1 - - - -
PRESENT 23 22 24 22 22 23
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 22 23
GROOMING COUNTS
MEAN 0.1 0.0 0.2 0.2 0.1 0.1
S.D. 0.46 0.21 0.59 0.53 0.47 0.29
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
URINATION COUNTS
MEAN 0.3 0.2 0.2 0.3 0.2 0.2
S.D. 0.78 0.42 0.48 0.48 0.39 0.39
N 23 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.3 0.1 0.6 1.0 0.3 1.0
S.D. 0.93 0.46 1.32 1.88 0.70 1.61
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
Page 163 of 4796
LD= LACTATIONAL DAY
PFOBGv1.52
01/12/2009
R:01/12/2009
TABLE 5 (F0)
Exposure Level (ppm)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
Day Statistic __________ __________ __________ __________ __________ __________ ____________
GD00 Mean 259 259 256 254 254 257

% Difference Control 0.0 -1.2 -1.9 -1.9 -0.8
S.D. 13.4 12.0 13.9 11.3 10.9 13.9
S.E. of Mean 2.8 2.5 2.8 2.3 2.2 2.8
N 23 23 24 24 24 24
LSMean 259 259 256 254 254 257
Dunnett p-value# 1.000 0.944 0.622 0.630 0.990
GD03 Mean 273 275 271 267 259 246

S.D. 13.9 14.4 15.3 13.1 12.8 15.9
Page 164 of 4796
S.E. of Mean 2.9 3.0 3.1 2.7 2.6 3.2

N 23 23 24 24 24 24
LSMean 273 275 271 267 259 246
Dunnett p-value# 0.992 0.988 0.482 0.004* <.001*
GD07 Mean 289 293 288 285 275 259

S.D. 18.6 17.0 15.6 14.6 15.4 17.9
S.E. of Mean 3.9 3.5 3.2 3.0 3.1 3.6
N 23 23 24 24 24 24
LSMean 289 293 288 285 275 259
Dunnett p-value# 0.951 0.998 0.793 0.018* <.001*
GD10 Mean 308 312 305 301 292 275

S.D. 17.9 17.1 18.0 16.2 16.4 16.1
S.E. of Mean 3.7 3.6 3.7 3.3 3.4 3.3
N 23 23 24 24 24 24
LSMean 308 312 305 301 292 275
Dunnett p-value# 0.875 0.973 0.533 0.007* <.001*
-------------------------------------------------------------------------------------------------------------------------------------
# P-values: listed under Statistical Model are tested at 0.05 level;
listed under individual dose group (pairwise comparison with control) are tested with Dunnett's at 0.05 level.
* : Statistically Significant. NT : Not tested. NA : Not applicable.
LSMean = Least squares mean. Mean adjusted for terms in the statistical model.
TABLE 5 (F0)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
Day Statistic __________ __________ __________ __________ __________ __________ ____________
GD14 Mean 328 332 328 319 311 294

% Difference Control 1.2 0.0 -2.7 -5.2 -10.4
S.D. 19.5 19.9 20.5 17.8 20.4 17.6
S.E. of Mean 4.1 4.2 4.2 3.6 4.2 3.6
N 23 23 24 24 24 24
LSMean 328 332 328 319 311 294
Dunnett p-value# 0.913 1.000 0.413 0.021* <.001*
GD17 Mean 358 362 359 349 341 325

S.D. 20.7 22.5 23.6 19.0 27.1 17.7
Page 165 of 4796
S.E. of Mean 4.3 4.7 4.8 3.9 5.5 3.6

N 23 23 24 24 24 24
LSMean 358 362 359 349 341 325
Dunnett p-value# 0.931 0.999 0.581 0.039* <.001*
GD20 Mean 406 410 407 397 387 371

S.D. 24.4 25.1 25.8 23.8 29.8 18.9
S.E. of Mean 5.1 5.2 5.3 4.8 6.1 3.9
N 23 23 24 24 24 24
LSMean 406 410 407 397 387 371
Dunnett p-value# 0.979 1.000 0.657 0.040* <.001*
Overall LSMean 317 320 316 310 303 289

Dunnett p-value# NT NT NT NT NT
Treatment*Time p-value# <.001*
-------------------------------------------------------------------------------------------------------------------------------------
Overall = Used for statistical model but not for interpretative purposes.
TABLE 6 (F0)
SPONSOR:ACC SUMMARY OF BODY WEIGHT CHANGES DURING GESTATION [G]

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
Day Statistic __________ __________ __________ __________ __________ __________ ____________
GD00_07 Mean 31 34 32 31 21 2
S.D. 9.9 8.5 8.6 7.0 8.0 15.6
S.E. of Mean 2.1 1.8 1.7 1.4 1.6 3.2
N 23 23 24 24 24 24
LSMean 31 34 32 31 21 2
Dunnett p-value# 0.749 0.999 1.000 0.003* <.001*
GD07_14 Mean 38 39 40 34 36 35
S.D. 6.9 7.4 8.4 11.6 8.2 9.7
S.E. of Mean 1.4 1.5 1.7 2.4 1.7 2.0
N 23 23 24 24 24 24
Page 166 of 4796
LSMean 38 39 40 34 36 35
Dunnett p-value# 0.994 0.940 0.427 0.913 0.603
GD14_20 Mean 78 78 79 78 75 77
S.D. 9.5 8.1 8.9 12.7 14.7 10.2
S.E. of Mean 2.0 1.7 1.8 2.6 3.0 2.1
N 23 23 24 24 24 24
LSMean 78 78 79 78 75 77
Dunnett p-value# 1.000 0.995 1.000 0.819 0.991
Overall LSMean 49 50 50 48 44 38
-------------------------------------------------------------------------------------------------------------------------------------
TABLE 6 (F0)
SPONSOR:ACC SUMMARY OF BODY WEIGHT CHANGES DURING GESTATION [G]

_________________________________________________________________
0 0.15 1.5 75 750 2250
Day Statistic __________ __________ __________ __________ __________ __________
GD00_20 Mean 147 151 151 143 133 114

S.D. 17.0 16.1 17.3 18.8 22.6 13.5
S.E. of Mean 3.6 3.4 3.5 3.8 4.6 2.8
N 23 23 24 24 24 24
LSMean 147.3 150.9 151.2 143.2 132.5 113.9
Dunnett p-value# 0.939 0.914 0.886 0.019* <.001*
Page 167 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
TABLE 7 (F0)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
Day Statistic __________ __________ __________ __________ __________ __________ ____________
01 Mean 301 309 303 296 289 273
S.D. 21.4 18.1 22.4 18.0 24.3 19.0
S.E. of Mean 4.5 3.8 4.6 3.7 5.0 4.0
N 23 23 24 24 24 23
LSMean 301 309 303 296 289 273
Dunnett p-value# 0.612 1.000 0.863 0.124 <.001*
04 Mean 312 317 316 310 297 282

S.D. 22.2 20.4 22.6 18.5 23.4 18.7
S.E. of Mean 4.6 4.3 4.6 3.8 4.8 3.9
Page 168 of 4796
N 23 23 24 24 24 23
LSMean 312 317 316 310 297 282
Dunnett p-value# 0.923 0.951 0.994 0.060 <.001*
07 Mean 318 323 321 317 306 292

S.D. 20.5 18.2 20.9 19.9 19.8 18.1
S.E. of Mean 4.3 3.8 4.3 4.2 4.2 3.8
N 23 23 24 22 22 23
LSMean 318 323 321 316 307 292
Dunnett p-value# 0.833 0.979 0.998 0.204 <.001*
11 Mean 334 335 334 329 318 307

S.D. 23.4 16.8 19.8 17.4 22.3 22.8
S.E. of Mean 4.9 3.5 4.0 3.7 4.8 4.8
N 23 23 24 22 22 23
LSMean 334 335 334 329 318 307
Dunnett p-value# 1.000 1.000 0.844 0.033* <.001*
-------------------------------------------------------------------------------------------------------------------------------------
TABLE 7 (F0)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
Day Statistic __________ __________ __________ __________ __________ __________ ____________
14 Mean 345 345 344 338 327 314

S.D. 19.8 17.9 20.5 17.6 20.1 17.9
S.E. of Mean 4.1 3.7 4.2 3.8 4.3 3.7
N 23 23 24 22 22 23
LSMean 345 345 344 338 328 314
Dunnett p-value# 1.000 0.999 0.483 0.007* <.001*
17 Mean 356 354 352 348 340 322

% Difference Control -0.6 -1.1 -2.2 -4.5 -9.6
S.D. 17.9 21.2 18.5 20.8 22.3 29.8
Page 169 of 4796
S.E. of Mean 3.7 4.4 3.8 4.4 4.8 6.2

N 23 23 24 22 22 23
LSMean 356 354 352 348 341 322
Dunnett p-value# 0.997 0.954 0.535 0.073 <.001*
21 Mean 339 346 344 327 332 331

S.D. 19.9 17.6 23.2 20.2 21.0 22.5
S.E. of Mean 4.1 3.7 4.7 4.3 4.5 4.7
N 23 23 24 22 22 23
LSMean 339 345 344 327 332 330
Dunnett p-value# 0.801 0.924 0.199 0.749 0.519
Overall LSMean 329 333 330 323 316 303

-------------------------------------------------------------------------------------------------------------------------------------
TABLE 8 (F0)
SPONSOR:ACC SUMMARY OF BODY WEIGHT CHANGES DURING LACTATION [G]
GROUP: 0 PPM 0.15 PPM 1.5 PPM 75 PPM 750 PPM 2250 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4
MEAN 11. 8. 13. 13. 9. 9.
S.D. 8.5 8.4 8.3 7.1 11.6 9.7
S.E. 1.8 1.7 1.7 1.5 2.4 2.0
N 23 23 24 24 24 23
DAY 4- 7
MEAN 6. 7. 5. 6. 10. 10.
S.D. 9.7 9.0 12.6 9.1 9.7 6.7
S.E. 2.0 1.9 2.6 2.0 2.1 1.4
N 23 23 24 22 22 23
DAY 7- 11
MEAN 16. 12. 13. 12. 11. 14.
Page 170 of 4796
S.D. 10.4 14.1 17.1 9.4 11.3 9.7

S.E. 2.2 2.9 3.5 2.0 2.4 2.0
N 23 23 24 22 22 23
DAY 11- 14
MEAN 12. 10. 10. 9. 9. 7.
S.D. 13.6 12.7 20.8 7.8 7.5 12.3
S.E. 2.8 2.7 4.2 1.7 1.6 2.6
N 23 23 24 22 22 23
DAY 14- 17
MEAN 11. 9. 8. 10. 13. 8.
S.D. 13.4 15.6 14.7 16.8 12.6 22.0
S.E. 2.8 3.3 3.0 3.6 2.7 4.6
N 23 23 24 22 22 23
DAY 17- 21
MEAN -17. -9. -8. -21. -8. 8.
S.D. 21.1 18.7 16.8 21.5 13.0 28.9
S.E. 4.4 3.9 3.4 4.6 2.8 6.0
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
MEAN DIFFERENCES CALCULATED FROM INDIVIDUAL DIFFERENCES
TABLE 8 (F0)
SPONSOR:ACC SUMMARY OF BODY WEIGHT CHANGES DURING LACTATION [G]
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 21
MEAN 38. 37. 41. 30. 44. 58.
S.D. 16.7 15.4 15.1 18.3 15.1 13.6
S.E. 3.5 3.2 3.1 3.9 3.2 2.8
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
PLBWSUv5.07
01/12/2009
Page 171 of 4796
TABLE 9 (F0)
SPONSOR:ACC SUMMARY OF FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
Day Statistic __________ __________ __________ __________ __________ __________ ____________
GD00_03 Mean 22 22 22 21 17 11
S.D. 1.4 2.0 1.9 2.0 3.6 2.8
S.E. of Mean 0.3 0.4 0.4 0.4 0.7 0.6
N 23 23 24 24 24 24
LSMean 22 22 22 21 17 11
Dunnett p-value# 1.000 1.000 0.425 <.001* <.001*
GD03_07 Mean 25 25 25 24 20 20
S.D. 2.1 2.3 2.4 2.1 3.3 3.7
S.E. of Mean 0.4 0.5 0.5 0.4 0.7 0.8
N 23 23 24 24 23 24
LSMean 25 25 25 24 20 20
Page 172 of 4796
Dunnett p-value# 1.000 0.998 0.855 <.001* <.001*
GD07_10 Mean 25 25 24 24 22 23
S.D. 1.7 2.3 2.7 2.2 2.5 5.3
S.E. of Mean 0.4 0.5 0.5 0.5 0.5 1.1
N 23 23 24 24 24 24
LSMean 25 25 24 24 22 23
Dunnett p-value# 1.000 0.987 0.558 0.030* 0.191
GD10_14 Mean 26 26 26 25 25 23
S.D. 1.8 2.5 3.1 2.7 3.4 2.5
S.E. of Mean 0.4 0.5 0.6 0.6 0.7 0.5
N 23 23 24 24 24 23
LSMean 26 26 26 25 25 23
Dunnett p-value# 1.000 1.000 0.217 0.174 0.001*
GD14_17 Mean 26 27 27 26 26 25
S.D. 1.9 2.7 3.2 2.7 3.8 2.1
S.E. of Mean 0.4 0.6 0.6 0.6 0.8 0.4
N 23 23 24 24 24 24
LSMean 26 27 27 26 26 25
Dunnett p-value# 0.964 0.969 0.988 0.905 0.076
-------------------------------------------------------------------------------------------------------------------------------------
TABLE 9 (F0)
SPONSOR:ACC SUMMARY OF FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
Day Statistic __________ __________ __________ __________ __________ __________ ____________
GD17_20 Mean 27 27 26 27 27 25
S.D. 2.4 2.7 2.9 2.4 3.2 2.4
S.E. of Mean 0.5 0.6 0.6 0.5 0.7 0.5
N 23 23 23 24 24 24
LSMean 27 27 26 27 27 25
Dunnett p-value# 1.000 0.980 0.993 0.993 0.053
Page 173 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
TABLE 10 (F0)
SPONSOR:ACC SUMMARY OF FOOD CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
Day Statistic __________ __________ __________ __________ __________ __________ ____________
01_04 Mean 38 36 37 38 34 36
S.D. 4.9 4.6 5.1 4.1 6.7 6.4
S.E. of Mean 1.1 1.0 1.1 0.9 1.4 1.5
N 19 20 20 21 23 17
LSMean 38 37 37 38 34 35
Dunnett p-value# 0.945 0.993 1.000 0.055 0.474
04_07 Mean 41 43 42 44 42 41
S.D. 3.7 4.9 4.0 5.0 5.7 4.1
S.E. of Mean 0.8 1.1 0.8 1.1 1.3 0.9
N 22 22 24 22 21 21
LSMean 41 43 42 44 42 42
Page 174 of 4796
Dunnett p-value# 0.833 0.973 0.170 0.996 1.000
07_11 Mean 54 53 53 54 50 51
S.D. 4.6 4.4 5.2 3.8 6.3 4.0
S.E. of Mean 1.0 0.9 1.1 0.8 1.4 0.9
N 23 22 24 22 21 20
LSMean 54 53 53 54 50 51
Dunnett p-value# 0.987 0.900 1.000 0.021* 0.147
11_14 Mean 63 63 62 62 59 59
S.D. 4.6 5.7 6.5 4.2 10.2 5.1
S.E. of Mean 1.0 1.2 1.3 0.9 2.2 1.1
N 23 23 24 22 22 23
LSMean 63 63 62 62 59 59
Dunnett p-value# 0.994 1.000 0.996 0.330 0.177
14_17 Mean 66 66 65 66 62 62
S.D. 6.2 5.6 5.5 7.1 7.7 7.5
S.E. of Mean 1.3 1.2 1.1 1.5 1.6 1.6
N 23 23 24 22 22 23
LSMean 66 66 65 66 62 62
Dunnett p-value# 1.000 0.998 1.000 0.245 0.292
-------------------------------------------------------------------------------------------------------------------------------------
TABLE 10 (F0)
SPONSOR:ACC SUMMARY OF FOOD CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
Day Statistic __________ __________ __________ __________ __________ __________ ____________
17_21 Mean 70 75 71 72 71 76
S.D. 6.2 9.0 8.4 5.7 11.2 8.3
S.E. of Mean 1.3 1.9 1.7 1.3 2.4 1.7
N 23 23 24 20 22 23
LSMean 70 75 71 73 71 76
Dunnett p-value# 0.218 0.997 0.871 1.000 0.081
Page 175 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
TABLE 11 (F0)
SPONSOR:ACC SUMMARY OF CALCULATED GESTATION TEST SUBSTANCE CONSUMPTION [MG/KG/DAY]
-----------------------------------------------------------------------------------------------------------------------------------
DAY 0- 3
MEAN 0.00 0.01 0.13 6.04 51.05 93.84
S.D. 0.000 0.001 0.008 0.443 9.564 21.962
S.E. 0.000 0.000 0.002 0.090 1.952 4.483
N 23 23 24 24 24 24
DAY 3- 7
MEAN 0.00 0.01 0.13 6.43 56.37 178.46
S.D. 0.000 0.001 0.009 0.491 8.137 32.511
S.E. 0.000 0.000 0.002 0.100 1.697 6.636
N 23 23 24 24 23 24
DAY 7- 10
MEAN 0.00 0.01 0.12 6.04 59.25 195.76
Page 176 of 4796
S.D. 0.000 0.001 0.009 0.444 5.944 47.726

S.E. 0.000 0.000 0.002 0.091 1.213 9.742
N 23 23 24 24 24 24
DAY 10- 14
MEAN 0.00 0.01 0.12 5.93 60.94 182.43
S.D. 0.000 0.001 0.009 0.592 6.533 16.434
S.E. 0.000 0.000 0.002 0.121 1.334 3.427
N 23 23 24 24 24 23
DAY 14- 17
MEAN 0.00 0.01 0.12 5.86 59.31 178.79
S.D. 0.000 0.001 0.009 0.570 6.122 13.757
S.E. 0.000 0.000 0.002 0.116 1.250 2.808
N 23 23 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN
TABLE 11 (F0)
SPONSOR:ACC SUMMARY OF CALCULATED GESTATION TEST SUBSTANCE CONSUMPTION [MG/KG/DAY]
-----------------------------------------------------------------------------------------------------------------------------------
DAY 17- 20
MEAN 0.00 0.01 0.10 5.32 54.55 161.89
S.D. 0.000 0.001 0.007 0.445 5.599 15.350
S.E. 0.000 0.000 0.002 0.091 1.143 3.133
N 23 23 23 24 24 24
DAY 0- 20
MEAN 0.00 0.01 0.12 5.85 56.43 163.93
S.D. 0.000 0.001 0.007 0.355 4.332 13.189
S.E. 0.000 0.000 0.002 0.072 0.884 2.692
N 23 23 23 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
NONGRAVID WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN
Page 177 of 4796
PGFWSUv5.14
01/12/2009
R:01/12/2009
TABLE 12 (F0)
SPONSOR:ACC SUMMARY OF CALCULATED LACTATION TEST SUBSTANCE CONSUMPTION [MG/KG/DAY]
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4
MEAN 0.00 0.02 0.18 9.31 86.87 287.74
S.D. 0.000 0.002 0.020 0.921 17.331 48.206
S.E. 0.000 0.000 0.004 0.201 3.614 11.692
N 19 20 20 21 23 17
DAY 4- 7
MEAN 0.00 0.02 0.20 10.61 104.11 326.04
S.D. 0.000 0.002 0.015 1.121 13.621 30.768
S.E. 0.000 0.000 0.003 0.239 2.972 6.714
N 22 22 24 22 21 21
DAY 7- 11
MEAN 0.00 0.02 0.24 12.57 119.82 384.13
Page 178 of 4796
S.D. 0.000 0.002 0.023 0.939 14.993 33.474

S.E. 0.000 0.000 0.005 0.200 3.272 7.485
N 23 22 24 22 21 20
DAY 11- 14
MEAN 0.00 0.03 0.28 13.93 138.34 426.15
S.D. 0.000 0.003 0.027 1.197 21.192 39.448
S.E. 0.000 0.001 0.006 0.255 4.518 8.225
N 23 23 24 22 22 23
DAY 14- 17
MEAN 0.00 0.03 0.28 14.47 140.56 440.97
S.D. 0.000 0.003 0.022 1.453 16.281 46.944
S.E. 0.000 0.001 0.005 0.310 3.471 9.789
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
TABLE 12 (F0)
SPONSOR:ACC SUMMARY OF CALCULATED LACTATION TEST SUBSTANCE CONSUMPTION [MG/KG/DAY]
-----------------------------------------------------------------------------------------------------------------------------------
DAY 17- 21
MEAN 0.00 0.03 0.31 16.13 158.03 526.70
S.D. 0.000 0.004 0.041 1.462 23.691 64.798
S.E. 0.000 0.001 0.008 0.327 5.051 13.511
N 23 23 24 20 22 23
DAY 1- 21
MEAN 0.00 0.03 0.25 13.14 128.61 410.45
S.D. 0.000 0.002 0.019 0.983 13.162 34.871
S.E. 0.000 0.000 0.004 0.220 2.806 8.458
N 19 20 20 20 22 17
-----------------------------------------------------------------------------------------------------------------------------------
PLFWSUv5.20
Page 179 of 4796
01/12/2009
R:01/12/2009
TABLE 13 (F0)
SPONSOR:ACC SUMMARY OF GESTATION LENGTHS [DAYS]
-----------------------------------------------------------------------------------------------------------------------------------
GESTATION LENGTH (DAYS)
MEAN 21.7 21.7 21.7 22.0 21.8 21.8
S.D. 0.45 0.45 0.46 0.20 0.51 0.41
S.E. 0.09 0.09 0.09 0.04 0.10 0.08
N 23 23 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
PGLv5.06
12/16/2008
R:07/13/2009
Page 180 of 4796
TABLE 14 (F0 - UNSCHEDULED DEATH)
SPONSOR:ACC SUMMARY OF MACROSCOPIC FINDINGS
FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS

-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER OF ANIMALS IN DOSE GROUP 24 24 24 24 24 24
NUMBER OF ANIMALS EXAMINED 0 0 0 0 0 1
SKIN
-MATTING, RED 0 0 0 0 0 1
STOMACH
-CONTENTS, DARK RED 0 0 0 0 0 1
-----------------------------------------------------------------------------------------------------------------------------------
Page 181 of 4796
PGRSI2v4.07
03/26/2009
TABLE 15 (F0 - FAILED TO DELIVER)
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
UTERUS
-CONTENTS, CLEAR FLUID 1 0 0 0 0 0
NO SIGNIFICANT CHANGES OBSERVED - ALL EXAMINED TISSUES 0 1 0 0 0 0

-----------------------------------------------------------------------------------------------------------------------------------
PGRSI2v4.07
Page 182 of 4796
03/26/2009
TABLE 16 (F0 - PUP SEX RATIO CRITERIA NOT MET)
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
PGRSI2v4.07
03/26/2009
Page 183 of 4796
TABLE 17 (F0 - LACTATION DAY 21)
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
DIAPHRAGM
-HERNIA 0 0 0 0 0 1
KIDNEYS
-AREA(S), DEPRESSED 0 2 1 2 1 1
-PALE 0 1 0 1 1 0
-DILATED PELVIS 0 0 0 0 0 2
Page 184 of 4796
LIVER
-DISCOLORATION, DARK RED 0 0 0 0 0 1
LUNGS
-AREA(S), DARK RED 0 0 0 0 0 1
SKIN
-HAIR LOSS 0 0 0 0 0 1
SPLEEN
-NODULE(S) 0 0 1 0 0 0
-AREA(S), WHITE 0 0 1 0 0 0
STOMACH
-CONTENTS, YELLOW 1 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
THYMUS
URETERS
-DISTENDED 0 0 0 0 0 1

-----------------------------------------------------------------------------------------------------------------------------------
Page 185 of 4796
PGRSI2v4.07
08/18/2009
TABLE 18 (F0)
SPONSOR:ACC SUMMARY OF IMPLANTATION SITES
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
IMPLANTATION SITES
MEAN 16.3 16.3 16.5 16.0 15.7 16.2
S.D. 1.28 2.20 1.90 2.35 1.86 1.50
S.E. 0.27 0.46 0.40 0.48 0.39 0.31
N 22-A 23 23-A 24 23 24
NUMBER BORN
MEAN 15.7 15.2 15.8 14.9 14.4 15.3
S.D. 1.55 2.19 1.86 2.87 1.90 1.69
S.E. 0.32 0.46 0.38 0.59 0.40 0.34
N 23 23 24 24 23 24
UNACCOUNTED SITES
MEAN 0.8 1.1 0.7 1.0 1.3 0.7
Page 186 of 4796
S.D. 0.81 1.00 0.82 2.01 1.46 0.86

S.E. 0.17 0.21 0.17 0.41 0.30 0.18
N 22-A 23 23-A 24 23 23-B
-----------------------------------------------------------------------------------------------------------------------------------
NOTE: ONLY DAMS THAT HAVE DELIVERED ONE OR MORE PUPS ARE INCLUDED IN CALCULATION OF MEAN.
A = NUMBER OF PUPS BORN EXCEEDED NUMBER OF IMPLANTATION SITES FOR 1 FEMALE; NOT INCLUDED IN CALCULATION OF MEANS.
B = FEMALE NO. 23237 WAS FOUND DEAD ON LACTATION DAY 0 WITH 3 FETUSES AND 1 EARLY RESORPTION RETAINED IN UTERO; NOT INCLUDED
IN CALCULATION OF MEAN.
PISSUv5.07
12/17/2008
R:07/13/2009
SPONSOR:ACC SUMMARY OF ORGAN WEIGHTS AND ORGAN WTS. RELATIVE TO BODY WTS.

_________________________________________________________________
0 0.15 1.5 75 750 2250
Organ Statistic __________ __________ __________ __________ __________ __________
KIDNEYS (G) Mean 2.60 2.68 2.65 2.58 2.53 2.52

S.D. 0.213 0.251 0.284 0.273 0.251 0.192
S.E. of Mean 0.044 0.052 0.058 0.058 0.054 0.040
N 23 23 24 22 22 23
LSMean 2.6 2.6 2.6 2.6 2.6 2.6
Dunnett p-value# 0.938 0.996 0.890 0.991 0.980
LIVER (G) Mean 15.99 16.06 15.92 14.92 15.14 14.95

S.D. 1.957 1.874 1.967 1.364 1.788 1.428
Page 187 of 4796
S.E. of Mean 0.408 0.391 0.402 0.291 0.381 0.298

N 23 23 24 22 22 23
LSMean 15.8 15.7 15.6 15.3 15.3 15.2
Dunnett p-value# 0.990 0.940 0.577 0.575 0.396
-------------------------------------------------------------------------------------------------------------------------------------
SPONSOR:ACC SUMMARY OF ORGAN WEIGHTS AND ORGAN WTS. RELATIVE TO BODY WTS.

_________________________________________________________________
0 0.15 1.5 75 750 2250
Organ Statistic __________ __________ __________ __________ __________ __________
KIDNEYS Mean 0.769 0.775 0.772 0.789 0.763 0.762

(G/100 G BODY WEIGHT) % Difference Control 0.8 0.4 2.6 -0.8 -0.9
S.D. 0.0567 0.0604 0.0642 0.0860 0.0509 0.0448
S.E. of Mean 0.0118 0.0126 0.0131 0.0183 0.0108 0.0093
N 23 23 24 22 22 23
LIVER Mean 4.713 4.646 4.626 4.564 4.562 4.531

(G/100 G BODY WEIGHT) % Difference Control -1.4 -1.8 -3.2 -3.2 -3.9
S.D. 0.4798 0.4550 0.4199 0.3337 0.4618 0.3951
S.E. of Mean 0.1001 0.0949 0.0857 0.0711 0.0985 0.0824
N 23 23 24 22 22 23
Page 188 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
Organ weight ratios relative to final body weights not statistically analyzed.
TABLE 20 (F0 - UNSCHEDULED DEATH)
SPONSOR:ACC SUMMARY OF MICROSCOPIC FINDINGS
----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
KIDNEYS
TOTAL NUMBER EXAMINED 0 0 0 0 0 1
EXAMINED, UNREMARKABLE 0 0 0 0 0 1
LIVER
-----------------------------------------------------------------------------------------------------------------------------------
Page 189 of 4796
PHSI2v4.30
03/26/2009
R:07/13/2009
TABLE 21 (F0 - FAILED TO DELIVER)
----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
KIDNEYS
-MINERALIZATION 0 1 0 0 0 0
MINIMAL NONE 1 NONE NONE NONE NONE
LIVER
Page 190 of 4796
-INFILTRATE, MONONUCLEAR 1 0 0 0 0 0
MINIMAL 1 NONE NONE NONE NONE NONE
-----------------------------------------------------------------------------------------------------------------------------------
PHSI2v4.30
03/26/2009
R:07/13/2009
TABLE 22 (F0 - PUP SEX RATIO CRITERIA NOT MET)
----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
KIDNEYS
-CYST 0 0 0 1 0 0
PRESENT NONE NONE NONE 1 NONE NONE
MINIMAL NONE NONE NONE NONE 2 NONE
-MINERALIZATION, PAPILLARY TUBULAR 0 0 0 0 1 0
Page 191 of 4796
LIVER
-HEMATOPOIESIS, EXTRAMEDULLARY 0 0 0 1 0 0
MILD NONE NONE NONE 1 NONE NONE
MINIMAL NONE NONE NONE 1 1 NONE
-----------------------------------------------------------------------------------------------------------------------------------
PHSI2v4.30
03/26/2009
R:07/13/2009
----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
DIAPHRAGM
TOTAL NUMBER EXAMINED NA NA NA NA NA 1
EXAMINED, UNREMARKABLE NA NA NA NA NA 0
-FIBROSIS NA NA NA NA NA 1
MILD NA NA NA NA NA 1
KIDNEYS
Page 192 of 4796
-#M NEPHROBLASTOMA 0 0 0 1 0 0
PRESENT NONE NONE NONE 1 NONE NONE
-BASOPHILIC TUBULES 0 1 0 0 1 1
MINIMAL NONE 1 NONE NONE 1 NONE
MODERATE NONE NONE NONE NONE NONE 1
-CYST 0 0 0 0 1 1
PRESENT NONE NONE NONE NONE 1 1
-DILATATION, TUBULAR 0 0 1 0 0 1
MINIMAL NONE NONE 1 NONE NONE 1
-HYDRONEPHROSIS 0 0 0 0 0 2
MILD NONE NONE NONE NONE NONE 2
MINIMAL 4 4 6 8 2 2
MINIMAL 7 9 10 10 4 8
MILD 1 NONE 2 NONE 2 3
-----------------------------------------------------------------------------------------------------------------------------------
# = NEOPLASM, M = MALIGNANT
NA = NOT APPLICABLE
----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
KIDNEYS - CONTINUED
-MINERALIZATION, PAPILLARY TUBULAR 0 1 0 1 1 1
MINIMAL NONE 1 NONE 1 1 1
-NEPHROPATHY, CHRONIC PROGRESSIVE 6 7 6 2 5 1
MINIMAL 6 6 6 2 5 1
MILD NONE 1 NONE NONE NONE NONE
LIVER
Page 193 of 4796
-FIBROSIS 0 0 0 0 0 1
-HEMATOPOIESIS, EXTRAMEDULLARY 0 0 0 0 2 0
-HEMORRHAGE 0 0 0 0 0 1
-HYPERPLASIA, BILE DUCT 0 0 1 0 0 0
MINIMAL NONE NONE 1 NONE NONE NONE
MINIMAL 19 22 21 21 22 18
MILD 1 NONE 1 NONE NONE NONE
-NECROSIS 1 0 1 0 1 0
MINIMAL NONE NONE 1 NONE 1 NONE
MILD 1 NONE NONE NONE NONE NONE
-----------------------------------------------------------------------------------------------------------------------------------
----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
LIVER - CONTINUED
-PIGMENT, BROWN 0 0 0 0 0 1
STOMACH
TOTAL NUMBER EXAMINED NA NA NA 1 NA NA
EXAMINED, UNREMARKABLE NA NA NA 0 NA NA
-EROSION NA NA NA 1 NA NA
MINIMAL NA NA NA 1 NA NA
Page 194 of 4796
THYMUS
TOTAL NUMBER EXAMINED NA NA NA 1 NA NA
EXAMINED, UNREMARKABLE NA NA NA 0 NA NA
-HEMORRHAGE NA NA NA 1 NA NA
MINIMAL NA NA NA 1 NA NA
URETERS
TOTAL NUMBER EXAMINED NA NA NA NA NA 1
EXAMINED, UNREMARKABLE NA NA NA NA NA 0
-DILATATION, LUMEN NA NA NA NA NA 1
MILD NA NA NA NA NA 1
-----------------------------------------------------------------------------------------------------------------------------------
NA = NOT APPLICABLE
PHSI2v4.30
08/18/2009
TABLE 24 (F1)
SPONSOR:ACC SUMMARY OF PND 0 LITTER DATA
GROUP : 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER BORN
MEAN 15.7 15.2 15.8 14.9 14.5 15.3
S.D. 1.55 2.19 1.86 2.87 1.89 1.69
S.E. 0.32 0.46 0.38 0.59 0.39 0.34
N 23 23 24 24 24 24
SEX AT BIRTH (% MALES PER LITTER)

MEAN 47.2 50.3 50.2 49.7 49.7 52.9
S.D. 14.57 12.62 10.78 11.71 14.40 13.70
S.E. 3.04 2.63 2.20 2.39 2.94 2.80
N 23 23 24 24 24 24
LIVE LITTER SIZE (PND 0)

Page 195 of 4796
MEAN 15.4 14.8 15.7 14.3 14.2 15.3

S.D. 1.31 2.33 1.90 3.12 2.28 1.65
S.E. 0.27 0.49 0.39 0.64 0.47 0.34
N 23 23 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
SEX AT BIRTH COMPARED USING DUNN'S, NUMBER BORN, AND LIVE LITTER SIZE COMPARED USING DUNNETT'S
-----------------------------------------------------------------------------------------------------------------------------------
* INDICATES PARAMETRIC ANALYSIS AND + INDICATES NON-PARAMETRIC ANALYSIS.
PPVIASv5.07
12/17/2008
R:07/13/2009
TABLE 25 (F1)
SPONSOR:ACC SUMMARY OF POSTNATAL SURVIVAL [% PER LITTER]
GROUP : 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
PND 0 (RELATIVE TO NUMBER BORN)

MEAN 98.2 97.4 99.2 96.1 97.7 99.5
S.D. 3.16 5.39 2.21 8.65 6.06 1.71
S.E. 0.66 1.12 0.45 1.76 1.24 0.35
N 23 23 24 24 24 24
PND 0 TO PND 1
MEAN 99.8 99.4 99.3 96.6 98.6 98.6
S.D. 1.16 1.99 2.52 10.26 4.73 2.76
S.E. 0.24 0.42 0.51 2.09 0.97 0.58
N 23 23 24 24 24 23
PND 1 TO PND 4 (PRE-SELECTION)

Page 196 of 4796
MEAN 99.2 98.7 98.7 98.8 99.5 98.4

S.D. 2.12 2.94 3.19 2.82 1.71 3.72
S.E. 0.44 0.61 0.65 0.58 0.35 0.78
N 23 23 24 24 24 23
PND 4 (POST-SELECTION) TO PND 7

MEAN 100.0 100.0 99.0 100.0 99.4 99.5
S.D. 0.00 0.00 3.53 0.00 2.67 2.61
S.E. 0.00 0.00 0.72 0.00 0.57 0.54
N 23 23 24 22 22 23
PND 7 TO PND 14
MEAN 98.9 100.0 98.3 100.0 97.7 99.5
S.D. 3.60 0.00 4.64 0.00 10.66 2.61
S.E. 0.75 0.00 0.95 0.00 2.27 0.54
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
TABLE 25 (F1)
SPONSOR:ACC SUMMARY OF POSTNATAL SURVIVAL [% PER LITTER]
GROUP : 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
PND 14 TO PND 21
MEAN 100.0 100.0 98.6 100.0 100.0 100.0
S.D. 0.00 0.00 6.80 0.00 0.00 0.00
S.E. 0.00 0.00 1.39 0.00 0.00 0.00
N 23 23 24 22 22 23
BIRTH TO PND 4 (PRE-SELECTION)

MEAN 97.2 95.5 97.2 92.3 96.0 96.5
S.D. 3.99 6.13 4.36 14.38 8.95 5.39
S.E. 0.83 1.28 0.89 2.93 1.83 1.12
N 23 23 24 24 24 23
Page 197 of 4796
PND 4 (POST-SELECTION) TO PND 21

MEAN 98.9 100.0 96.4 100.0 97.2 98.9
S.D. 3.60 0.00 11.35 0.00 10.86 3.60
S.E. 0.75 0.00 2.32 0.00 2.32 0.75
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
STATISTICS PERFORMED USING DUNN'S
-----------------------------------------------------------------------------------------------------------------------------------
PPVIASv5.07
12/17/2008
R:07/13/2009
TABLE 26 (F1)
SPONSOR:ACC SUMMARY OF PUP CLINICAL OBSERVATIONS
ALL OBSERVATION PERIODS

TOTAL NUMBER OF FINDINGS/NUMBER OF PUPS WITH FINDING
-----------------------------------------------------------------------------------------------------------------------------------
FINDING GROUP : 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NORMAL
NO REMARKABLE OBSERVATIONS 712/ 348 696/ 332 733/ 365 681/ 329 670/ 333 704/ 340
DISPOSITION
FOUND DEAD 9/ 9 14/ 14 15/ 15 22/ 22 13/ 13 11/ 11
EUTHANIZED IN EXTREMIS 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0
SCHEDULED EUTHANASIA (PND 21) 90/ 90 92/ 92 90/ 90 88/ 88 84/ 84 90/ 90
CULLED ON SCHEDULED DAY (PND 4) 166/ 166 149/ 149 177/ 177 142/ 142 144/ 144 159/ 159
SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET (PND 4) 0/ 0 0/ 0 0/ 0 12/ 12 16/ 16 0/ 0
MISSING 4/ 4 2/ 2 3/ 3 6/ 6 4/ 4 4/ 4
SENT TO NECROPSY DUE TO DEATH OF DAM 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0 12/ 12
Page 198 of 4796
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 92/ 92 92/ 92 95/ 95 88/ 88 86/ 86 92/ 92
BEHAVIOR/CNS
HYPOACTIVITY 0/ 0 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0
BODY/INTEGUMENT
LACERATION 0/ 0 1/ 1 0/ 0 1/ 1 1/ 1 1/ 1
SUBCUTANEOUS HEMORRHAGE(S) 1/ 1 1/ 1 0/ 0 0/ 0 1/ 1 0/ 0
SMALL STATURE 1/ 1 1/ 1 10/ 7 1/ 1 3/ 3 3/ 3
BODY PALE 1/ 1 3/ 3 1/ 1 0/ 0 1/ 1 1/ 1
BODY COOL 0/ 0 1/ 1 0/ 0 0/ 0 2/ 2 0/ 0
REDDENED PLANTAR SURFACE OF LEFT HINDLIMB 0/ 0 0/ 0 0/ 0 0/ 0 3/ 3 0/ 0
REDDENED PLANTAR SURFACE OF RIGHT HINDLIMB 0/ 0 0/ 0 0/ 0 0/ 0 3/ 3 0/ 0
REDDENED PALMAR SURFACE OF RIGHT FORELIMB 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0
REDDENED PALMAR SURFACE OF LEFT FORELIMB 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0
-----------------------------------------------------------------------------------------------------------------------------------
TABLE 26 (F1)
SPONSOR:ACC SUMMARY OF PUP CLINICAL OBSERVATIONS

TOTAL NUMBER OF FINDINGS/NUMBER OF PUPS WITH FINDING
-----------------------------------------------------------------------------------------------------------------------------------
FINDING GROUP : 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
BODY/INTEGUMENT
SCABBING 0/ 0 1/ 1 0/ 0 0/ 0 1/ 1 0/ 0
CARDIO-PULMONARY
GASPING 0/ 0 0/ 0 3/ 3 4/ 4 2/ 2 0/ 0
LABORED RESPIRATION 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0
EYES/EARS/NOSE
EXOPHTHALMUS 0/ 0 2/ 1 0/ 0 0/ 0 0/ 0 0/ 0
BUPHTHALMOS 0/ 0 2/ 1 0/ 0 0/ 0 0/ 0 0/ 0
EYELIDS COMPLETELY SHUT 0/ 0 0/ 0 0/ 0 0/ 0 2/ 1 0/ 0
Page 199 of 4796
WET RED MATERIAL AROUND RIGHT EYE 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0

-----------------------------------------------------------------------------------------------------------------------------------
PPOBSIv4.07
02/04/2009
R:07/13/2009
TABLE 27 (F1)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
Sex Day Statistic __________ __________ __________ __________ __________ __________ ____________
P PND_01 Mean 6.8 7.0 6.8 7.2 6.9 6.6

% Difference Control 2.9 0.0 5.9 1.5 -2.9
S.D. 0.59 0.65 0.69 0.69 0.69 0.63
S.E. of Mean 0.12 0.13 0.14 0.14 0.14 0.13
N (Litters) 23 23 24 24 24 23
PND_04 Mean 9.2 9.6 9.2 9.9 9.4 8.7

S.D. 0.92 1.11 1.17 1.07 1.12 1.11
S.E. of Mean 0.19 0.23 0.24 0.22 0.23 0.23
N (Litters) 23 23 24 24 24 23
Page 200 of 4796
Overall Treatment*Sex p-value# 0.631

Treatment*Sex*Time p-value# <.001*
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.
TABLE 27 (F1)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P PND_04A Mean 9.2 9.6 9.2 9.9 9.4 8.7

S.D. 0.95 1.17 1.19 1.09 1.14 1.11
S.E. of Mean 0.20 0.24 0.24 0.22 0.23 0.23
N (Litters) 23 23 24 24 24 23
PND_07 Mean 15.1 15.6 15.2 16.0 15.2 14.4

S.D. 1.57 1.84 1.97 1.56 1.80 2.03
S.E. of Mean 0.33 0.38 0.40 0.33 0.38 0.42
N (Litters) 23 23 24 22 22 23
Page 201 of 4796
PND_11 Mean 24.6 25.2 24.3 25.3 23.7 22.7

% Difference Control 2.4 -1.2 2.8 -3.7 -7.7
S.D. 1.92 2.52 2.55 2.55 3.03 2.45
S.E. of Mean 0.40 0.53 0.52 0.54 0.65 0.51
N (Litters) 23 23 24 22 22 23
PND_14 Mean 32.6 33.2 32.3 33.1 30.9 30.3

S.D. 1.77 2.71 2.69 2.91 4.33 2.79
S.E. of Mean 0.37 0.57 0.55 0.62 0.92 0.58
N (Litters) 23 23 24 22 22 23
PND_17 Mean 39.8 40.8 39.8 40.5 37.9 37.1

% Difference Control 2.5 0.0 1.8 -4.8 -6.8
S.D. 2.08 3.08 3.09 3.52 5.19 3.61
S.E. of Mean 0.43 0.64 0.63 0.75 1.11 0.75
N (Litters) 23 23 24 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined. A = Body weight following culling.
TABLE 27 (F1)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P PND_21 Mean 51.2 53.0 51.3 52.7 49.1 48.3

S.D. 3.57 4.90 4.70 5.22 6.89 4.52
S.E. of Mean 0.74 1.02 0.96 1.11 1.47 0.94
N (Litters) 23 23 24 22 22 23

Page 202 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.
TABLE 27 (F1)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M PND_01 Mean 7.0 7.2 7.0 7.4 7.1 6.8

S.D. 0.63 0.69 0.71 0.70 0.73 0.65
S.E. of Mean 0.13 0.14 0.15 0.14 0.15 0.14
N (Litters) 23 23 24 24 24 23
LSMean 7.0 7.2 6.9 7.4 7.0 6.8
Dunnett p-value# 0.718 0.998 0.118 0.998 0.679
PND_04 Mean 9.5 9.8 9.5 10.2 9.6 9.0

S.D. 0.96 1.16 1.25 1.14 1.12 1.14
Page 203 of 4796
S.E. of Mean 0.20 0.24 0.25 0.23 0.23 0.24

N (Litters) 23 23 24 24 24 23
LSMean 9.4 9.8 9.4 10.1 9.5 8.9
Dunnett p-value# 0.212 1.000 0.002* 0.962 0.067
Overall LSMean 8.2 8.5 8.2 8.8 8.3 7.8

-------------------------------------------------------------------------------------------------------------------------------------
TABLE 27 (F1)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M PND_04A Mean 9.4 9.8 9.6 10.2 9.7 9.0

S.D. 0.95 1.22 1.29 1.16 1.16 1.11
S.E. of Mean 0.20 0.26 0.26 0.24 0.24 0.23
N (Litters) 23 23 24 24 24 23
LSMean 9.4 9.8 9.6 10.2 9.6 9.0
Dunnett p-value# 0.330 0.956 0.012* 0.843 0.334
PND_07 Mean 15.4 16.0 15.7 16.6 15.6 14.8

S.D. 1.60 1.95 2.19 1.65 1.85 2.07
Page 204 of 4796
S.E. of Mean 0.33 0.41 0.45 0.35 0.39 0.43

N (Litters) 23 23 24 22 22 23
LSMean 15.4 16.0 15.8 16.7 15.6 14.8
Dunnett p-value# 0.322 0.784 <.001* 0.953 0.245
PND_11 Mean 25.1 25.8 25.0 26.1 24.1 23.4

S.D. 2.09 2.55 2.81 2.57 3.08 2.41
S.E. of Mean 0.44 0.53 0.57 0.55 0.66 0.50
N (Litters) 23 23 24 22 22 23
LSMean 25.0 25.8 25.0 26.2 24.1 23.3
Dunnett p-value# 0.320 1.000 0.048* 0.165 0.001*
PND_14 Mean 33.2 33.7 32.9 34.0 31.6 31.1

S.D. 2.10 2.87 2.89 2.92 4.12 2.85
S.E. of Mean 0.44 0.60 0.59 0.62 0.88 0.60
N (Litters) 23 23 24 22 22 23
LSMean 33.1 33.7 32.8 34.2 31.4 31.0
Dunnett p-value# 0.623 0.984 0.166 0.012* <.001*
-------------------------------------------------------------------------------------------------------------------------------------
A = Body weight following culling.
TABLE 27 (F1)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M PND_17 Mean 40.6 41.6 40.5 41.6 38.7 38.1

S.D. 2.50 3.36 3.30 3.49 4.84 3.73
S.E. of Mean 0.52 0.70 0.67 0.74 1.03 0.78
N (Litters) 23 23 24 22 22 23
LSMean 40.4 41.6 40.3 41.8 38.5 37.9
Dunnett p-value# 0.236 1.000 0.163 0.016* <.001*
PND_21 Mean 52.2 54.3 52.5 54.4 50.2 49.7

S.D. 3.96 5.66 5.33 5.23 6.58 5.04
Page 205 of 4796
S.E. of Mean 0.83 1.18 1.09 1.12 1.40 1.05

N (Litters) 23 23 24 22 22 23
LSMean 52.0 54.4 52.3 54.6 50.1 49.5
Dunnett p-value# 0.046* 0.996 0.025* 0.159 0.034*
Overall LSMean 29.2 30.2 29.3 30.6 28.2 27.6

-------------------------------------------------------------------------------------------------------------------------------------
TABLE 27 (F1)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F PND_01 Mean 6.6 6.8 6.5 7.0 6.8 6.4

% Difference Control 3.0 -1.5 6.1 3.0 -3.0
S.D. 0.62 0.66 0.69 0.70 0.67 0.67
S.E. of Mean 0.13 0.14 0.14 0.14 0.14 0.14
N (Litters) 23 23 24 24 24 23
LSMean 6.6 6.8 6.6 6.9 6.7 6.4
Dunnett p-value# 0.731 0.998 0.276 0.927 0.484
PND_04 Mean 8.9 9.3 8.9 9.6 9.2 8.4

S.D. 0.96 1.11 1.18 1.04 1.15 1.09
Page 206 of 4796
S.E. of Mean 0.20 0.23 0.24 0.21 0.23 0.23

N (Litters) 23 23 24 24 24 23
LSMean 8.9 9.2 8.9 9.4 9.1 8.3
Dunnett p-value# 0.425 1.000 0.031* 0.777 0.029*
Overall LSMean 7.7 8.0 7.7 8.2 7.9 7.4

-------------------------------------------------------------------------------------------------------------------------------------
TABLE 27 (F1)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F PND_04A Mean 9.0 9.3 8.9 9.6 9.2 8.4

S.D. 1.02 1.15 1.18 1.05 1.18 1.13
S.E. of Mean 0.21 0.24 0.24 0.21 0.24 0.24
N (Litters) 23 23 24 24 24 23
LSMean 9.0 9.3 8.9 9.5 9.2 8.4
Dunnett p-value# 0.702 0.997 0.137 0.810 0.142
PND_07 Mean 14.7 15.2 14.7 15.4 14.8 13.9

S.D. 1.67 1.86 1.93 1.55 1.88 2.03
Page 207 of 4796
S.E. of Mean 0.35 0.39 0.39 0.33 0.40 0.42

N (Litters) 23 23 24 22 22 23
LSMean 14.7 15.2 14.7 15.5 14.9 13.9
Dunnett p-value# 0.591 1.000 0.104 0.988 0.074
PND_11 Mean 24.1 24.6 23.7 24.6 23.3 22.1

S.D. 1.96 2.65 2.60 2.60 3.15 2.58
S.E. of Mean 0.41 0.55 0.53 0.55 0.67 0.54
N (Litters) 23 23 24 22 22 23
LSMean 24.0 24.6 23.7 24.7 23.4 22.0
Dunnett p-value# 0.682 0.952 0.522 0.555 <.001*
PND_14 Mean 32.0 32.6 31.6 32.2 30.2 29.6

S.D. 1.72 2.86 2.83 3.00 4.57 2.85
S.E. of Mean 0.36 0.60 0.58 0.64 0.97 0.59
N (Litters) 23 23 24 22 22 23
LSMean 31.9 32.6 31.6 32.3 30.5 29.4
Dunnett p-value# 0.574 0.965 0.909 0.047* <.001*
-------------------------------------------------------------------------------------------------------------------------------------
TABLE 27 (F1)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F PND_17 Mean 39.1 40.0 39.1 39.5 37.3 36.2

S.D. 1.95 3.12 3.36 3.69 5.54 3.64
S.E. of Mean 0.41 0.65 0.69 0.79 1.18 0.76
N (Litters) 23 23 24 22 22 23
LSMean 39.0 40.0 39.0 39.6 37.5 36.1
Dunnett p-value# 0.470 1.000 0.888 0.080 <.001*
PND_21 Mean 50.2 51.7 50.0 51.1 48.1 46.8

S.D. 3.52 4.59 4.48 5.36 7.20 4.13
Page 208 of 4796
S.E. of Mean 0.73 0.96 0.91 1.14 1.54 0.86

N (Litters) 23 23 24 22 22 23
LSMean 50.2 51.7 49.9 51.2 48.4 46.6
Dunnett p-value# 0.301 0.995 0.690 0.151 <.001*
Overall LSMean 28.1 28.9 27.9 28.8 27.3 26.1

-------------------------------------------------------------------------------------------------------------------------------------
TABLE 28 (F1)
SPONSOR:ACC SUMMARY OF OFFSPRING WEIGHT CHANGES [G]

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P PND_01-04 Mean 2.4 2.6 2.5 2.7 2.5 2.1

S.D. 0.43 0.64 0.61 0.66 0.63 0.64
S.E. of Mean 0.09 0.13 0.13 0.14 0.13 0.13
N (Litters) 23 23 24 24 24 23
LSMean 2.4 2.6 2.4 2.7 2.5 2.1
Dunnett p-value# 0.737 0.987 0.145 0.967 0.320
Treatment*Sex p-value# 0.736
Page 209 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.
TABLE 28 (F1)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P PND_04-07A Mean 5.9 6.0 6.0 6.2 5.8 5.6

S.D. 0.70 0.81 0.87 0.70 0.85 1.01
S.E. of Mean 0.15 0.17 0.18 0.15 0.18 0.21
N (Litters) 23 23 24 22 22 23
PND_07-14 Mean 17.4 17.6 17.0 17.1 15.6 16.0

S.D. 1.16 1.31 1.52 1.63 3.38 1.57
S.E. of Mean 0.24 0.27 0.31 0.35 0.72 0.33
N (Litters) 23 23 24 22 22 23
PND_14-21 Mean 18.6 19.8 18.9 19.6 18.3 17.9

Page 210 of 4796
S.D. 2.69 2.68 2.48 2.84 2.96 2.02

S.E. of Mean 0.56 0.56 0.51 0.61 0.63 0.42
N (Litters) 23 23 24 22 22 23

-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined. A = Body weight following culling.
TABLE 28 (F1)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M PND_01-04 Mean 2.5 2.6 2.6 2.8 2.5 2.1

S.D. 0.42 0.67 0.67 0.71 0.62 0.65
S.E. of Mean 0.09 0.14 0.14 0.15 0.13 0.14
N (Litters) 23 23 24 24 24 23
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX interaction.
Page 211 of 4796
TABLE 28 (F1)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M PND_04-07A Mean 6.0 6.1 6.2 6.5 6.0 5.8

S.D. 0.73 0.89 1.00 0.70 0.89 1.06
S.E. of Mean 0.15 0.19 0.20 0.15 0.19 0.22
N (Litters) 23 23 24 22 22 23
LSMean 6.0 6.1 6.2 6.5 6.0 5.8
Dunnett p-value# 0.972 0.926 0.162 1.000 0.809
PND_07-14 Mean 17.7 17.7 17.2 17.4 15.9 16.3

S.D. 1.29 1.39 1.62 1.67 3.20 1.73
S.E. of Mean 0.27 0.29 0.33 0.36 0.68 0.36
N (Litters) 23 23 24 22 22 23
Page 212 of 4796
LSMean 17.7 17.7 17.1 17.4 16.2 16.2

Dunnett p-value# 1.000 0.370 0.948 <.001* <.001*
PND_14-21 Mean 19.0 20.6 19.6 20.3 18.7 18.6

S.D. 2.88 3.18 3.02 2.90 2.92 2.43
S.E. of Mean 0.60 0.66 0.62 0.62 0.62 0.51
N (Litters) 23 23 24 22 22 23
LSMean 18.9 20.6 19.5 20.4 18.8 18.5
Dunnett p-value# 0.006* 0.674 0.030* 1.000 0.910
Overall LSMean 14.2 14.8 14.3 14.8 13.7 13.5

-------------------------------------------------------------------------------------------------------------------------------------
TABLE 28 (F1)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F PND_01-04 Mean 2.3 2.5 2.3 2.7 2.4 2.0

S.D. 0.45 0.64 0.61 0.67 0.65 0.64
S.E. of Mean 0.09 0.13 0.12 0.14 0.13 0.13
N (Litters) 23 23 24 24 24 23
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX interaction.
Page 213 of 4796
TABLE 28 (F1)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F PND_04-07A Mean 5.8 5.9 5.9 6.0 5.7 5.5

S.D. 0.75 0.84 0.85 0.74 0.88 0.99
S.E. of Mean 0.16 0.17 0.17 0.16 0.19 0.21
N (Litters) 23 23 24 22 22 23
LSMean 5.8 5.9 5.9 6.0 5.7 5.5
Dunnett p-value# 0.973 0.992 0.858 0.990 0.730
PND_07-14 Mean 17.2 17.5 16.8 16.8 15.4 15.6

S.D. 1.17 1.44 1.61 1.71 3.55 1.55
S.E. of Mean 0.24 0.30 0.33 0.36 0.76 0.32
N (Litters) 23 23 24 22 22 23
Page 214 of 4796
LSMean 17.2 17.4 16.9 16.8 15.6 15.6

Dunnett p-value# 0.927 0.842 0.733 <.001* <.001*
PND_14-21 Mean 18.3 19.1 18.3 18.8 17.9 17.3

S.D. 2.64 2.41 2.12 2.90 3.05 1.72
S.E. of Mean 0.55 0.50 0.43 0.62 0.65 0.36
N (Litters) 23 23 24 22 22 23
LSMean 18.3 19.1 18.3 18.8 17.9 17.2
Dunnett p-value# 0.313 1.000 0.669 0.921 0.113
Overall LSMean 13.7 14.1 13.7 13.9 13.0 12.8

-------------------------------------------------------------------------------------------------------------------------------------
TABLE 29 (F1 - FOUND DEAD OR EUTHANIZED IN EXTREMIS PUPS)
SPONSOR:ACC SUMMARY OF PUP NECROPSY FINDINGS
FOUND DEAD PUPS

-----------------------------------------------------------------------------------------------------------------------------------
P U P S L I T T E R S
DOSE GROUP: 1 2 3 4 5 6 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER EXAMINED VISCERALLY 9 14 15 22 14 11 8 9 8 8 6 7
PAWS
REDDENED 0 0 0 0 2 0 0 0 0 0 1 0
EYES
HEMORRHAGIC RING AROUND THE IRIS 0 0 0 0 0 1 0 0 0 0 0 1
LIVER
SWOLLEN 0 0 0 0 0 1 0 0 0 0 0 1
Page 215 of 4796
STOMACH
MILK NOT PRESENT 7 8 3 14 7 4 6 5 3 4 3 4
MILK PRESENT 0 0 0 0 1 0 0 0 0 0 1 0
KIDNEY
RENAL PAPILLA NOT FULLY DEVELOPED (WOO AND HOAR GRADE 1) 0 0 0 1 0 0 0 0 0 1 0 0
BLADDER
CONTENTS, RED FLUID 0 0 0 0 1 0 0 0 0 0 1 0
MALFORMATION
LUNGS- LOBULAR DYSGENESIS 0 0 0 0 0 1 0 0 0 0 0 1
SITUS INVERSUS 0 0 0 0 0 1 0 0 0 0 0 1
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
PPNSIv4.03
12/17/2008
R:07/13/2009
TABLE 30 (F1 - PUPS EUTHANIZED DUE TO DEATH OF DAM, SEX RATIO CRITERIA NOT MET, OR ON PND 21)
SPONSOR:ACC SUMMARY OF PUP NECROPSY FINDINGS
EUTHANIZED PUPS
-----------------------------------------------------------------------------------------------------------------------------------
P U P S L I T T E R S
DOSE GROUP: 1 2 3 4 5 6 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NUMBER EXAMINED VISCERALLY 44 46 43 56 56 56 23 23 22 24 23 24
EYES
ATROPHY 0 0 0 0 1 0 0 0 0 0 1 0
KIDNEY
DILATED PELVIS 0 0 0 1 0 1 0 0 0 1 0 1
-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 216 of 4796
PPNSIv4.03
12/17/2008
R:07/13/2009
TABLE 31 (F1)
SPONSOR:ACC SUMMARY OF DEVELOPMENTAL LANDMARKS SURFACE RIGHTING RESPONSE

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
Sex Statistic __________ __________ __________ __________ __________ __________ ____________
P Mean (Day) 6.7 6.6 6.3 6.2 6.3 6.3

S.D. 1.15 1.22 1.01 1.21 1.26 0.88
S.E. of Mean 0.24 0.25 0.21 0.26 0.27 0.18
N (Litters) 23 23 24 22 22 23
LSMean 6.7 6.7 6.3 6.1 6.3 6.3
Dunnett p-value# 1.000 0.645 0.274 0.564 0.683
M Mean (Day) 6.5 6.3 6.0 5.8 5.9 5.9

S.D. 1.33 1.44 1.19 1.59 1.34 0.96
S.E. of Mean 0.28 0.30 0.24 0.34 0.29 0.20
Page 217 of 4796
N (Litters) 23 23 24 22 22 23
F Mean (Day) 7.0 7.1 6.7 6.5 6.7 6.8

S.D. 1.19 1.18 1.11 1.20 1.30 1.04
S.E. of Mean 0.25 0.25 0.23 0.26 0.28 0.22
N (Litters) 23 23 24 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.
TABLE 32 (F1 SUBSET A)
PROJECT NO.:WIL-186056A DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF DEVELOPMENTAL LANDMARKS BALANOPREPUTIAL SEPARATION

_________________________________________________________________
0 0.15 1.5 75 750 2250
Statistic __________ __________ __________ __________ __________ __________
Mean (Day) 44.8 46.0 44.8 44.3 44.6 45.0

S.D. 2.66 5.04 2.19 2.44 2.25 2.93
S.E. of Mean 0.55 1.05 0.45 0.52 0.49 0.61
N (Litters) 23 23 24 22 21 23
LSMean 44.8 46.0 44.7 44.3 44.7 45.0
Dunnett p-value# 0.479 1.000 0.978 1.000 1.000
Mean (Body Weight) 246.2 262.3 247.5 245.1 243.1 240.3

S.D. 27.58 34.66 16.84 15.40 20.30 20.00
S.E. of Mean 5.75 7.23 3.44 3.28 4.43 4.17
Page 218 of 4796
N 23 23 24 22 21 23
-------------------------------------------------------------------------------------------------------------------------------------
PROJECT NO.:WIL-186056D DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF DEVELOPMENTAL LANDMARKS VAGINAL PATENCY

_________________________________________________________________
0 0.15 1.5 75 750 2250
Statistic __________ __________ __________ __________ __________ __________
Mean (Day) 32.3 32.4 32.9 32.8 33.3 32.7

S.D. 0.88 1.04 1.70 1.95 2.33 1.19
S.E. of Mean 0.18 0.22 0.35 0.42 0.50 0.25
N (Litters) 23 23 24 22 22 23
LSMean 32.3 32.5 32.9 32.8 33.3 32.7
Dunnett p-value# 0.997 0.548 0.739 0.110 0.865
Mean (Body Weight) 116.7 121.9 118.9 117.7 119.4 111.0

S.D. 8.86 12.46 10.43 12.21 13.77 9.40
S.E. of Mean 1.85 2.60 2.13 2.60 2.94 1.96
Page 219 of 4796
N 23 23 24 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------
TABLE 34 (F1 MALES - SUBSETS A AND B)
----- M A L E -----
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 08-31-08 TO 11-16-08
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NORMAL
DISPOSITION
-EUTHANIZED IN EXTREMIS 0/ 0 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0
-SCHEDULED EUTHANASIA; SUBSET B 23/23 23/23 22/22 22/22 21/21 23/23
-FOUND DEAD 0/ 0 0/ 0 2/ 2 0/ 0 0/ 0 0/ 0
-SCHEDULED EUTHANASIA; SUBSET A 23/23 23/23 23/23 22/22 21/21 23/23
BEHAVIOR/CNS
-IMPAIRED USE OF LEFT HINDLIMB 0/ 0 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0
Page 220 of 4796
-IMPAIRED USE OF RIGHT HINDLIMB 0/ 0 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0

-EXCESSIVE VOCALIZATION 0/ 0 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0
BODY/INTEGUMENT
-SCABBING VENTRAL NECK 1/ 1 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0
-SCABBING DORSAL HEAD 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0
-HAIR LOSS DORSAL HEAD 1/ 1 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0
-SCABBING RIGHT FORELIMB 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0
-SCABBING LEFT FORELIMB 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0
-----------------------------------------------------------------------------------------------------------------------------------
TABLE 34 (F1 MALES - SUBSETS A AND B)
----- M A L E -----
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 08-31-08 TO 11-16-08
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
BODY/INTEGUMENT
-SCABBING RIGHT LATERAL THORACIC AREA 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0
EYES/EARS/NOSE
-DRIED RED MATERIAL AROUND NOSE 0/ 0 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0
-LACRIMATION RIGHT EYE 2/ 1 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0
-OPACITY LEFT EYE 9/ 1 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0
-OPACITY RIGHT EYE 9/ 1 9/ 1 0/ 0 0/ 0 0/ 0 0/ 0
ORAL/DENTAL
Page 221 of 4796
-UPPER INCISORS MALALIGNED 0/ 0 0/ 0 3/ 1 0/ 0 0/ 0 0/ 0

-----------------------------------------------------------------------------------------------------------------------------------
PCSUv4.07
02/04/2009
R:07/13/2009
TABLE 35 (F1 FEMALES - SUBSETS A AND B)
----- F E M A L E -----
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 09-01-08 TO 11-16-08
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NORMAL
DISPOSITION
-SCHEDULED EUTHANASIA; SUBSET B 23/23 23/23 23/23 22/22 22/22 23/23
-FOUND DEAD 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0
-SCHEDULED EUTHANASIA; SUBSET A 22/22 23/23 24/24 22/22 22/22 23/23
BODY/INTEGUMENT
-SCABBING RIGHT LATERAL NECK 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0
Page 222 of 4796

-HAIR LOSS VENTRAL NECK 4/ 1 0/ 0 4/ 1 0/ 0 0/ 0 0/ 0
-HAIR LOSS LEFT HINDLIMB 0/ 0 0/ 0 2/ 1 0/ 0 0/ 0 0/ 0
-HAIR LOSS RIGHT LATERAL NECK 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0 0/ 0
-HAIR LOSS VENTRAL THORACIC AREA 0/ 0 0/ 0 2/ 1 0/ 0 0/ 0 0/ 0
-HAIR LOSS VENTRAL ABDOMINAL AREA 0/ 0 0/ 0 2/ 1 0/ 0 0/ 0 0/ 0
-HAIR LOSS DORSAL HEAD 1/ 1 0/ 0 0/ 0 0/ 0 2/ 1 0/ 0
-SCABBING DORSAL HEAD 1/ 1 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0
-SCABBING VENTRAL NECK 3/ 1 0/ 0 0/ 0 0/ 0 0/ 0 0/ 0
EYES/EARS/NOSE
-OPACITY RIGHT EYE 0/ 0 6/ 1 0/ 0 0/ 0 0/ 0 0/ 0
-----------------------------------------------------------------------------------------------------------------------------------
TABLE 35 (F1 FEMALES - SUBSETS A AND B)
----- F E M A L E -----
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 09-01-08 TO 11-16-08
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
EYES/EARS/NOSE
-LACRIMATION RIGHT EYE 0/ 0 1/ 1 0/ 0 1/ 1 0/ 0 0/ 0
-EXOPHTHALMUS LEFT EYE 0/ 0 0/ 0 4/ 1 0/ 0 0/ 0 0/ 0
-RIGHT PUPIL ELONGATED VERTICALLY; PUPIL 0/ 0 1/ 1 0/ 0 0/ 0 2/ 1 0/ 0
ORIENTED TOWARD BOTTOM EDGE OF EYE
ORAL/DENTAL
-UPPER INCISORS MALALIGNED 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0 0/ 0
-----------------------------------------------------------------------------------------------------------------------------------
Page 223 of 4796
PCSUv4.07
02/04/2009
R:07/13/2009
SPONSOR:ACC SUMMARY OF BODY WEIGHTS [G]

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P PND028 Mean 90 93 90 91 88 86
S.D. 9.1 10.0 9.7 10.6 11.8 10.3
S.E. of Mean 1.3 1.5 1.4 1.6 1.8 1.5
N 46 46 48 44 43 46
PND035 Mean 144 150 145 144 142 138

S.D. 17.4 18.6 17.8 19.4 20.3 18.4
S.E. of Mean 2.6 2.7 2.6 2.9 3.1 2.7
N 46 46 48 44 43 46
Page 224 of 4796
PND042 Mean 197 204 197 198 193 190

S.D. 31.6 31.8 31.9 33.9 34.7 31.8
S.E. of Mean 4.7 4.7 4.6 5.1 5.3 4.7
N 45 46 48 44 43 46
PND049 Mean 239 248 241 242 236 234

S.D. 49.1 48.8 48.6 53.2 51.5 48.9
S.E. of Mean 7.3 7.2 7.0 8.0 7.9 7.2
N 45 46 48 44 43 46
PND056 Mean 281 292 280 286 279 277

S.D. 66.3 68.2 67.2 71.7 70.4 68.0
S.E. of Mean 9.9 10.1 9.8 10.8 10.7 10.0
N 45 46 47 44 43 46
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P PND063 Mean 311 324 311 317 307 304

S.D. 76.1 77.1 78.0 82.9 80.7 79.0
S.E. of Mean 11.3 11.4 11.4 12.5 12.3 11.6
N 45 46 47 44 43 46
PND070 Mean 332 344 332 339 330 325

S.D. 83.7 85.7 86.2 92.4 88.7 86.8
S.E. of Mean 12.5 12.6 12.6 13.9 13.5 12.8
N 45 46 47 44 43 46
Page 225 of 4796

-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M PND028 Mean 94 97 94 96 93 91
S.D. 8.6 11.1 8.7 10.4 11.7 8.7
S.E. of Mean 1.8 2.3 1.8 2.2 2.6 1.8
N 23 23 24 22 21 23
LSMean 94 97 94 96 92 91
PND035 Mean 156 161 157 158 154 149

S.D. 14.1 17.7 12.9 16.0 17.2 14.9
Page 226 of 4796
S.E. of Mean 2.9 3.7 2.6 3.4 3.8 3.1

N 23 23 24 22 21 23
LSMean 156 161 157 158 154 149
PND042 Mean 223 230 224 227 221 216

S.D. 18.7 22.4 17.2 19.9 22.9 20.6
S.E. of Mean 3.9 4.7 3.5 4.2 5.0 4.3
N 23 23 24 22 21 23
LSMean 223 230 224 227 221 216
PND049 Mean 283 291 286 290 283 276

S.D. 24.1 26.4 19.4 28.8 25.0 29.0
S.E. of Mean 5.0 5.5 4.0 6.1 5.5 6.1
N 23 23 24 22 21 23
LSMean 283 291 286 290 283 276
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M PND056 Mean 341 355 345 352 344 338

S.D. 28.1 31.3 21.7 34.7 30.5 35.3
S.E. of Mean 5.9 6.5 4.5 7.4 6.6 7.4
N 23 23 23 22 21 23
LSMean 341 354 346 352 344 338
PND063 Mean 380 395 387 394 383 376

S.D. 29.7 35.3 23.9 35.4 34.1 38.7
Page 227 of 4796
S.E. of Mean 6.2 7.4 5.0 7.6 7.4 8.1

N 23 23 23 22 21 23
LSMean 380 395 388 394 383 376
PND070 Mean 410 423 416 425 414 404

S.D. 29.2 39.1 24.5 38.2 37.6 42.7
S.E. of Mean 6.1 8.2 5.1 8.1 8.2 8.9
N 23 23 23 22 21 23
LSMean 410 423 417 425 414 404
Overall LSMean 270 279 273 277 270 264

Dunnett p-value# 0.547 0.980 0.703 1.000 0.896
Treatment*Time p-value# 0.574
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F PND028 Mean 87 89 86 85 85 80
S.D. 8.0 6.9 8.9 8.2 10.6 9.3
S.E. of Mean 1.7 1.4 1.8 1.8 2.3 1.9
N 23 23 24 22 22 23
LSMean 87 89 86 85 85 80
PND035 Mean 132 138 132 131 130 126

S.D. 11.2 11.0 12.9 10.4 15.3 13.2
Page 228 of 4796
S.E. of Mean 2.3 2.3 2.6 2.2 3.3 2.7

N 23 23 24 22 22 23
LSMean 132 138 132 131 130 126
PND042 Mean 169 178 170 169 166 164

S.D. 12.5 12.1 15.1 14.7 19.4 14.8
S.E. of Mean 2.7 2.5 3.1 3.1 4.1 3.1
N 22 23 24 22 22 23
LSMean 171 178 170 169 166 164
PND049 Mean 194 204 196 195 191 192

S.D. 15.0 16.0 16.4 16.6 19.9 17.0
S.E. of Mean 3.2 3.3 3.3 3.5 4.2 3.5
N 22 23 24 22 22 23
LSMean 196 204 196 195 191 191
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F PND056 Mean 218 229 218 221 216 215

S.D. 15.6 17.3 19.0 17.5 25.5 17.8
S.E. of Mean 3.3 3.6 3.9 3.7 5.4 3.7
N 22 23 24 22 22 23
LSMean 220 229 218 221 216 215
PND063 Mean 238 253 239 240 234 232

S.D. 17.8 18.4 21.8 20.0 24.5 21.1
Page 229 of 4796
S.E. of Mean 3.8 3.8 4.4 4.3 5.2 4.4

N 22 23 24 22 22 23
LSMean 240 252 239 240 234 232
PND070 Mean 251 265 252 253 250 245

S.D. 18.4 20.3 21.7 22.8 25.7 21.7
S.E. of Mean 3.9 4.2 4.4 4.9 5.5 4.5
N 22 23 24 22 22 23
LSMean 253 265 252 253 250 245
Overall LSMean 185 193 185 185 182 179

Dunnett p-value# 0.295 1.000 1.000 0.887 0.511
-------------------------------------------------------------------------------------------------------------------------------------
TABLE 37 (F1 MALES - SUBSET A)
SPONSOR:ACC SUMMARY OF BODY WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
MALES
-----------------------------------------------------------------------------------------------------------------------------------
PND 28- 35
MEAN 62. 64. 62. 63. 62. 59.
S.D. 6.8 8.5 4.8 6.8 7.0 7.3
S.E. 1.4 1.8 1.0 1.4 1.5 1.5
N 23 23 24 22 21 23
PND 35- 42
MEAN 67. 69. 67. 69. 67. 67.
S.D. 6.3 7.4 5.8 6.0 7.0 7.5
S.E. 1.3 1.6 1.2 1.3 1.5 1.6
N 23 23 24 22 21 23
PND 42- 49
Page 230 of 4796
MEAN 59. 61. 61. 63. 62. 60.

S.D. 8.5 7.1 5.1 10.3 7.3 10.0
S.E. 1.8 1.5 1.0 2.2 1.6 2.1
N 23 23 24 22 21 23
PND 49- 56
MEAN 59. 64. 60. 62. 61. 62.
S.D. 7.9 10.3 7.9 7.5 9.9 10.7
S.E. 1.6 2.1 1.6 1.6 2.2 2.2
N 23 23 23 22 21 23
PND 56- 63
MEAN 39. 40. 42. 42. 39. 38.
S.D. 8.9 8.9 14.5 6.8 7.8 7.0
S.E. 1.9 1.9 3.0 1.4 1.7 1.5
N 23 23 23 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
TABLE 37 (F1 MALES - SUBSET A)
-----------------------------------------------------------------------------------------------------------------------------------
MALES
-----------------------------------------------------------------------------------------------------------------------------------
PND 63- 70
MEAN 29. 28. 30. 31. 31. 28.
S.D. 7.0 8.3 8.1 7.3 7.2 9.6
S.E. 1.5 1.7 1.7 1.6 1.6 2.0
N 23 23 23 22 21 23
PND 70- 72
MEAN 12. 12. 10. 11. 12. 13.
S.D. 5.3 6.4 5.0 6.4 5.4 9.7
S.E. 1.1 1.3 1.1 1.4 1.2 2.0
N 23 23 23 22 21 23
PND 28- 72
Page 231 of 4796
MEAN 328. 338. 332. 341. 333. 326.

S.D. 27.8 34.6 20.9 32.2 32.4 38.3
S.E. 5.8 7.2 4.4 6.9 7.1 8.0
N 23 23 23 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
PJTBWSUv5.15
03/24/2009
R:07/13/2009
TABLE 38 (F1 FEMALES - SUBSET A)
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
-----------------------------------------------------------------------------------------------------------------------------------
PND 28- 35
MEAN 46. 49. 46. 45. 45. 45.
S.D. 6.3 6.1 6.2 4.1 6.1 4.9
S.E. 1.3 1.3 1.3 0.9 1.3 1.0
N 23 23 24 22 22 23
PND 35- 42
MEAN 38. 40. 38. 39. 36. 38.
S.D. 6.2 5.4 7.1 8.0 7.0 6.4
S.E. 1.3 1.1 1.5 1.7 1.5 1.3
N 22 23 24 22 22 23
PND 42- 49
Page 232 of 4796
MEAN 25. 27. 26. 26. 25. 27.

S.D. 5.1 6.1 5.9 7.8 5.7 6.1
S.E. 1.1 1.3 1.2 1.7 1.2 1.3
N 22 23 24 22 22 23
PND 49- 56
MEAN 24. 25. 22. 25. 25. 24.
S.D. 7.1 10.0 8.5 5.2 8.4 7.6
S.E. 1.5 2.1 1.7 1.1 1.8 1.6
N 22 23 24 22 22 23
PND 56- 63
MEAN 20. 23. 21. 19. 18. 17.
S.D. 7.5 8.1 8.1 5.8 5.3 6.6
S.E. 1.6 1.7 1.7 1.2 1.1 1.4
N 22 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
TABLE 38 (F1 FEMALES - SUBSET A)
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
-----------------------------------------------------------------------------------------------------------------------------------
PND 63- 70
MEAN 14. 12. 13. 14. 16. 13.
S.D. 8.0 8.0 8.7 5.8 4.7 6.1
S.E. 1.7 1.7 1.8 1.2 1.0 1.3
N 22 23 24 22 22 23
PND 70- 72
MEAN 5. 7. 5. 4. 5. 7.
S.D. 7.5 6.5 8.0 6.1 7.6 5.8
S.E. 1.6 1.4 1.6 1.3 1.6 1.2
N 22 23 24 22 22 23
PND 28- 72
Page 233 of 4796
MEAN 170. 183. 170. 171. 170. 172.

S.D. 15.5 18.7 21.4 18.7 18.2 20.0
S.E. 3.3 3.9 4.4 4.0 3.9 4.2
N 22 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
PJTBWSUv5.14
01/12/2009
R:07/13/2009
TABLE 39 (F1 - SUBSET A)
PROJECT NO.:WIL-186056S DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF DETAILED CLINICAL OBSERVATIONS PND 4
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------


VERY EASY 22 21 21 21 20 21
EASY 1 2 3 1 2 2
WITH VOCALIZATION 1 2 3 1 2 2

LOW 23 23 24 22 22 23
Page 234 of 4796
LACRIMATION
NONE 23 23 24 22 22 23
CHROMODACRYORRHEA
ABSENT 23 23 24 22 22 23
SALIVATION
NONE 23 23 24 22 22 23
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NORMAL 23 23 24 22 22 23
RED DEPOSITS - EYES

ABSENT 23 23 24 22 22 23
RED DEPOSITS - NOSE

ABSENT 23 23 24 22 22 23

ABSENT 23 23 24 22 22 23
Page 235 of 4796

ABSENT 23 23 24 22 22 23

PRESENT 1 - - - 1 -
ABSENT 22 23 24 22 21 23

PRESENT 1 - - - - -
ABSENT 22 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

PINK 23 23 24 22 22 23
SKIN COLOR
PINK 23 23 24 22 22 23
MUSCLE TONE
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 22 23
Page 236 of 4796
CONVULSIONS-TONIC
ABSENT 23 23 24 22 22 23
TREMORS
NONE 23 23 24 22 22 23
AROUSAL
NORMAL 23 23 24 22 22 23
NONE 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
URINATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
Page 237 of 4796
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------


VERY EASY 23 19 23 20 20 22
EASY - 4 1 2 2 1

LOW 23 23 24 22 22 23
Page 238 of 4796
LACRIMATION
NONE 23 23 24 22 22 23
CHROMODACRYORRHEA
ABSENT 23 23 24 22 22 23
SALIVATION
NONE 23 23 24 22 22 23
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NORMAL 23 23 24 22 22 23
RED DEPOSITS - EYES

ABSENT 23 23 24 22 22 23
RED DEPOSITS - NOSE

ABSENT 23 23 24 22 22 23

ABSENT 23 23 24 22 22 23
Page 239 of 4796

ABSENT 23 23 24 22 22 23

ABSENT 23 23 24 22 22 23

ABSENT 23 23 24 22 22 23

PINK 23 23 24 22 22 22
PALE - - - - - 1
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
SKIN COLOR
PINK 23 23 24 22 22 22
PALE - - - - - 1
MUSCLE TONE
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 22 23
CONVULSIONS-TONIC
Page 240 of 4796
ABSENT 23 23 24 22 22 23
TREMORS
NONE 23 23 24 22 22 23
AROUSAL
NORMAL 23 23 24 22 22 23
NONE 23 23 24 22 22 23
URINATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.21 0.00 0.00
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
DEFECATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
Page 241 of 4796
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ASLEEP - - 1 - - 1

VERY EASY 19 21 20 20 20 19
EASY 4 2 4 2 2 4
WITH VOCALIZATION 3 2 4 2 2 4
WITHOUT VOCALIZATION 1 - - - - -

Page 242 of 4796
LOW 20 21 21 20 21 20
MODERATELY LOW 3 2 3 2 1 3
WITH VOCALIZATION 2 2 3 2 - 2
WITHOUT VOCALIZATION 1 - - - 1 1
LACRIMATION
NONE 23 23 24 22 22 23
CHROMODACRYORRHEA
ABSENT 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
SALIVATION
NONE 23 23 24 22 22 23
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 22 23
NORMAL 23 23 24 22 22 23
RED DEPOSITS - EYES

ABSENT 23 23 24 22 22 23
Page 243 of 4796
RED DEPOSITS - NOSE

ABSENT 23 23 24 22 22 23

ABSENT 23 23 24 22 22 23

ABSENT 23 23 24 22 22 23

PRESENT - 1 - - - 1
ABSENT 23 22 24 22 22 22
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ABSENT 23 23 24 22 22 23

PINK 23 23 24 22 22 23
SKIN COLOR
PINK 23 23 23 22 22 23
PALE - - 1 - - -
MUSCLE TONE
Page 244 of 4796
MOBILITY
NORMAL 23 23 24 22 22 23
GAIT
NORMAL 23 23 24 22 22 23
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 21 22
CONVULSIONS, POPCORN SEIZURE - - - - 1 1
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
CONVULSIONS-TONIC
ABSENT 23 23 24 22 22 23
TREMORS
NONE 23 23 24 22 22 23
AROUSAL
LOW - - 1 - 1 -
NORMAL 23 23 23 22 21 23
NONE 23 23 24 22 22 23
Page 245 of 4796
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 22 23
URINATION COUNTS
MEAN 0.2 0.3 0.3 0.3 0.3 0.3
S.D. 0.39 0.47 0.46 0.48 0.48 0.45
N 23 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.21 0.00 0.00
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ASLEEP - 2 - - - 1

VERY EASY 20 23 24 20 22 21
EASY 3 - - 2 - 2
WITH VOCALIZATION 3 - - 2 - 2

LOW 20 22 23 22 22 19
Page 246 of 4796
MODERATELY LOW 3 1 1 - - 4
WITH VOCALIZATION 3 1 1 - - 4
LACRIMATION
NONE 23 23 24 22 22 23
CHROMODACRYORRHEA
ABSENT 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
SALIVATION
NONE 23 23 24 22 22 23
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 22 23
NORMAL 23 23 24 22 22 23
RED DEPOSITS - EYES

ABSENT 23 23 24 22 22 23
Page 247 of 4796
RED DEPOSITS - NOSE

ABSENT 23 23 24 22 22 23

ABSENT 23 23 24 22 22 23

ABSENT 23 23 24 22 22 23

ABSENT 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ABSENT 23 23 24 22 22 23

PINK 23 23 24 22 22 23
SKIN COLOR
PINK 23 23 24 22 22 23
MUSCLE TONE
Page 248 of 4796
MOBILITY
NORMAL 23 23 24 22 22 23
GAIT
NORMAL 23 23 24 22 22 23
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 21 20
CONVULSIONS - - - - 1 1
CONVULSIONS, POPCORN SEIZURE - - - - - 2
CONVULSIONS-TONIC
ABSENT 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
TREMORS
NONE 23 23 24 22 22 23
AROUSAL
NORMAL 23 23 24 22 22 23
NONE 23 23 24 22 22 23
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
Page 249 of 4796
S.D. 0.00 0.00 0.00 0.00 0.00 0.00

N 23 23 24 22 22 23
URINATION COUNTS
MEAN 0.4 0.3 0.2 0.2 0.5 0.3
S.D. 0.50 0.54 0.41 0.43 0.60 0.47
N 23 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ASLEEP 4 1 4 4 3 3
ALERT 6 3 4 5 6 5

VERY EASY 23 23 24 21 21 23
EASY - - - 1 - -
WITH VOCALIZATION - - - 1 - -

Page 250 of 4796
LOW 23 23 24 22 21 22
MODERATELY LOW - - - - - 1
WITH VOCALIZATION - - - - - 1
LACRIMATION
NONE 23 23 24 22 21 23
CHROMODACRYORRHEA
ABSENT 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
SALIVATION
NONE 23 23 24 22 21 23
PILOERECTION
NONE 23 23 24 22 21 23
FUR APPEARANCE
PALPEBRAL CLOSURE
Page 251 of 4796
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 21 23
NORMAL 23 23 24 22 21 23
RED DEPOSITS - EYES

PRESENT - - 1 - - -
ABSENT 23 23 23 22 21 23
RED DEPOSITS - NOSE

PRESENT 1 1 3 - 1 1
ABSENT 22 22 21 22 20 22
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ABSENT 23 23 24 22 21 23

ABSENT 23 23 24 22 21 23

PRESENT - - - - - 1
ABSENT 23 23 24 22 21 22

ABSENT 23 23 24 22 21 23
Page 252 of 4796

PINK 23 23 23 22 21 23
PALE - - 1 - - -
EYE COLOR
PINK 23 23 23 22 21 23
PALE - - 1 - - -
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
SKIN COLOR
PINK 23 23 23 22 21 23
PALE - - 1 - - -
EYE PROMINENCE
NORMAL 23 23 24 22 21 23
MUSCLE TONE
MOBILITY
Page 253 of 4796
NORMAL 23 23 24 22 21 23
GAIT
NORMAL 23 23 24 22 21 23
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 21 23
CONVULSIONS-TONIC
ABSENT 23 23 24 22 21 23
TREMORS
NONE 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
AROUSAL
NORMAL 23 23 24 22 21 23
NONE 23 23 24 22 21 23
PUPILLARY RESPONSE
ABSENT 1 - - - - -
PRESENT 22 23 24 22 21 23
BACKING COUNTS
Page 254 of 4796
MEAN 0.0 0.0 0.0 0.0 0.0 0.0

S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 21 23
GROOMING COUNTS
MEAN 0.1 0.0 0.0 0.1 0.0 0.0
S.D. 0.29 0.21 0.20 0.29 0.00 0.00
N 23 23 24 22 21 23
URINATION COUNTS
MEAN 0.2 0.0 0.1 0.2 0.1 0.1
S.D. 0.49 0.21 0.34 0.39 0.36 0.46
N 23 23 24 22 21 23
DEFECATION COUNTS
MEAN 0.7 0.5 0.7 0.7 0.4 0.5
S.D. 1.18 0.95 1.08 1.16 0.98 0.99
N 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ASLEEP 1 1 2 2 5 3
ALERT 5 1 4 6 6 2

VERY EASY 22 21 23 22 21 23
EASY 1 2 1 - 1 -
WITH VOCALIZATION 1 2 1 - 1 -

Page 255 of 4796
LOW 23 22 23 21 22 23
MODERATELY LOW - 1 1 1 - -
WITH VOCALIZATION - 1 1 1 - -
LACRIMATION
NONE 23 23 24 22 22 23
CHROMODACRYORRHEA
ABSENT 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
SALIVATION
NONE 23 23 24 22 22 23
PILOERECTION
NONE 23 23 24 22 22 23
FUR APPEARANCE
PALPEBRAL CLOSURE
Page 256 of 4796
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 22 23
NORMAL 23 23 24 22 22 23
RED DEPOSITS - EYES

PRESENT - 1 - - - -
ABSENT 23 22 24 22 22 23
RED DEPOSITS - NOSE

PRESENT - 2 - 3 1 1
ABSENT 23 21 24 19 21 22
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ABSENT 23 23 24 22 22 23

ABSENT 23 23 24 22 22 23

ABSENT 23 23 24 22 22 23

ABSENT 23 23 24 22 22 23
Page 257 of 4796

PINK 23 23 23 22 22 23
PALE - - 1 - - -
EYE COLOR
PINK 23 23 23 22 22 23
PALE - - 1 - - -
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
SKIN COLOR
PINK 23 23 23 22 22 23
PALE - - 1 - - -
EYE PROMINENCE
NORMAL 23 23 24 22 22 23
MUSCLE TONE
MOBILITY
NORMAL 23 23 24 22 22 23
Page 258 of 4796
GAIT
NORMAL 23 23 24 22 22 23
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 22 23
CONVULSIONS-TONIC
ABSENT 23 23 24 22 22 23
TREMORS
NONE 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
AROUSAL
NORMAL 23 23 24 22 22 23
NONE 23 23 24 22 22 23
PUPILLARY RESPONSE
PRESENT 23 23 24 22 22 23
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
Page 259 of 4796
N 23 23 24 22 22 23
GROOMING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.1 0.1
S.D. 0.00 0.21 0.20 0.21 0.29 0.63
N 23 23 24 22 22 23
URINATION COUNTS
MEAN 0.0 0.1 0.0 0.1 0.0 0.0
S.D. 0.00 0.29 0.20 0.29 0.00 0.21
N 23 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.2 0.4 0.5 0.3 0.3 0.4
S.D. 0.58 1.12 1.02 0.70 0.63 0.84
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ASLEEP 5 9 3 3 2 4
ALERT 8 6 10 7 10 8
REARING - 1 3 2 3 6+

VERY EASY 23 21 22 21 20 22
EASY - 2 2 1 1 1
WITHOUT VOCALIZATION - - 1 - - -
Page 260 of 4796

LOW 23 23 24 22 21 23
LACRIMATION
NONE 23 23 24 22 21 23
CHROMODACRYORRHEA
ABSENT 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
SALIVATION
NONE 23 23 24 22 21 23
PILOERECTION
NONE 23 23 24 22 21 23
FUR APPEARANCE
PALPEBRAL CLOSURE
Page 261 of 4796
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 21 23
NORMAL 23 23 24 22 21 23
RED DEPOSITS - EYES

ABSENT 23 23 24 22 21 23
RED DEPOSITS - NOSE

PRESENT 2 - 2 3 1 3
ABSENT 21 23 22 19 20 20
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ABSENT 23 23 24 22 21 23

ABSENT 23 23 24 22 21 23

PRESENT - 1 2 1 - -
ABSENT 23 22 22 21 21 23

Page 262 of 4796
ABSENT 23 23 24 22 21 23

PINK 23 23 24 22 21 23
EYE COLOR
PINK 23 23 24 22 21 23
SKIN COLOR
PINK 23 23 24 22 21 23
EYE PROMINENCE
NORMAL 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
MUSCLE TONE
MOBILITY
NORMAL 23 23 24 22 21 23
GAIT
NORMAL 23 23 24 22 21 23
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 21 23
Page 263 of 4796
CONVULSIONS-TONIC
ABSENT 23 23 24 22 21 23
TREMORS
NONE 23 23 24 22 21 23
AROUSAL
NORMAL 23 23 24 22 21 23
NONE 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
PUPILLARY RESPONSE
ABSENT 1 - - - - -
PRESENT 22 23 24 22 21 23
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 21 23
GROOMING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.2 0.0
Page 264 of 4796
S.D. 0.00 0.00 0.00 0.21 0.68 0.00

N 23 23 24 22 21 23
URINATION COUNTS
MEAN 0.1 0.2 0.2 0.2 0.0 0.3
S.D. 0.29 0.42 0.51 0.39 0.00 0.45
N 23 23 24 22 21 23
DEFECATION COUNTS
MEAN 0.0 0.3 0.6 0.1 0.6 0.1
S.D. 0.21 1.30 1.59 0.64 1.66 0.42
N 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ASLEEP 5 1 -+ 2 1 2
ALERT 10 9 10 9 13 13
REARING 3 3 4 3 3 4

VERY EASY 22 21 23 20 22 22
EASY 1 2 1 2 - 1
WITH VOCALIZATION 1 2 1 2 - 1
Page 265 of 4796

LOW 23 23 23 20 22 23
MODERATELY LOW - - 1 2 - -
WITH VOCALIZATION - - 1 2 - -
LACRIMATION
NONE 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
CHROMODACRYORRHEA
ABSENT 23 23 24 22 22 23
SALIVATION
NONE 23 23 24 22 22 23
PILOERECTION
NONE 23 23 24 22 22 23
FUR APPEARANCE
Page 266 of 4796
PALPEBRAL CLOSURE
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 22 23
NORMAL 23 23 24 22 22 23
RED DEPOSITS - EYES

ABSENT 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
RED DEPOSITS - NOSE

PRESENT 1 - - - - -
ABSENT 22 23 24 22 22 23

ABSENT 23 23 24 22 22 23

ABSENT 23 23 24 22 22 23

Page 267 of 4796
PRESENT 1 - 1 - 1 -
ABSENT 22 23 23 22 21 23

ABSENT 23 23 24 22 22 23

PINK 23 23 24 22 22 23
EYE COLOR
PINK 23 23 24 22 22 23
SKIN COLOR
PINK 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
EYE PROMINENCE
NORMAL 23 23 24 22 22 23
MUSCLE TONE
MOBILITY
NORMAL 23 23 24 22 22 23
GAIT
NORMAL 23 23 24 22 22 23
Page 268 of 4796
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 22 23
CONVULSIONS-TONIC
ABSENT 23 23 24 22 22 23
TREMORS
NONE 23 23 24 22 22 23
AROUSAL
NORMAL 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NONE 23 23 24 22 22 23
PUPILLARY RESPONSE
PRESENT 23 23 24 22 22 23
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 22 23
GROOMING COUNTS
Page 269 of 4796
MEAN 0.0 0.0 0.0 0.0 0.0 0.0

S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 22 23
URINATION COUNTS
MEAN 0.1 0.1 0.1 0.0 0.0 0.2
S.D. 0.29 0.29 0.34 0.00 0.21 0.52
N 23 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.0 0.2 0.2 0.0 0.0 0.0
S.D. 0.00 1.04 0.82 0.00 0.00 0.00
N 23 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ASLEEP 1 - 1 - - 4
ALERT 4 2 5 2 3 2
REARING - 1 1 2 - 1

VERY EASY 22 22 23 22 20 22
EASY 1 1 1 - 1 1
WITH VOCALIZATION 1 1 1 - - -
WITHOUT VOCALIZATION - - - - 1 1
Page 270 of 4796

LOW 22 22 24 22 20 22
MODERATELY LOW 1 1 - - 1 1
WITH VOCALIZATION 1 1 - - - -
WITHOUT VOCALIZATION - - - - 1 1
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION
NONE 22 23 24 22 21 23
SEVERE 1 - - - - -
CHROMODACRYORRHEA
ABSENT 22 23 24 22 21 23
PRESENT 1 - - - - -
SALIVATION
NONE 23 23 24 22 21 23
PILOERECTION
Page 271 of 4796
NONE 23 23 24 22 21 23
FUR APPEARANCE
PALPEBRAL CLOSURE
RESPIRATORY RATE
NORMAL (80-110) 23 23 24 22 21 23
NORMAL 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
RED DEPOSITS - EYES

PRESENT 1 - - - - -
ABSENT 22 23 24 22 21 23
RED DEPOSITS - NOSE

PRESENT 1 - 2 1 - -
ABSENT 22 23 22 21 21 23

ABSENT 23 23 24 22 21 23
Page 272 of 4796

ABSENT 23 23 24 22 21 23

PRESENT - - 1 - - -
ABSENT 23 23 23 22 21 23

PRESENT - - - - 1 -
ABSENT 23 23 24 22 20 23

PINK 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
EYE COLOR
PINK 23 23 24 22 21 23
SKIN COLOR
PINK 23 23 24 22 21 23
EYE PROMINENCE
NORMAL 23 23 24 22 21 23
MUSCLE TONE
Page 273 of 4796
MOBILITY
NORMAL 23 23 24 22 21 23
GAIT
NORMAL 23 23 24 22 21 23
CONVULSIONS-CLONIC
ABSENT 23 23 24 22 21 23
CONVULSIONS-TONIC
ABSENT 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
TREMORS
NONE 23 23 24 22 21 23
AROUSAL
NORMAL 23 23 24 22 21 23
NONE 23 23 24 22 21 23
PUPILLARY RESPONSE
ABSENT 1 - - - - -
PRESENT 22 23 24 22 21 23
Page 274 of 4796
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 24 22 21 23
GROOMING COUNTS
MEAN 0.1 0.1 0.1 0.0 0.0 0.1
S.D. 0.63 0.42 0.28 0.00 0.00 0.29
N 23 23 24 22 21 23
URINATION COUNTS
MEAN 0.5 0.4 0.3 0.3 0.3 0.1
S.D. 0.85 0.95 0.64 0.70 0.64 0.29
N 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
DEFECATION COUNTS
MEAN 0.0 0.0 0.0 0.2* 0.0 0.0
S.D. 0.00 0.00 0.20 0.61 0.00 0.00
N 23 23 24 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
Page 275 of 4796
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ALERT 4 3 6 3 3 2
REARING 2 2 3 3 3 1

VERY EASY 22 21 23 20 20 23
EASY - 2 1 2 2 -
WITHOUT VOCALIZATION - 2 - - 2 -
Page 276 of 4796

LOW 21 21 23 20 19 23
MODERATELY LOW 1 2 1 2 3 -
WITHOUT VOCALIZATION 1 2 - - 3 -
LACRIMATION
NONE 22 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
CHROMODACRYORRHEA
ABSENT 22 23 24 22 22 23
SALIVATION
NONE 22 23 24 22 22 23
PILOERECTION
NONE 22 23 24 22 22 23
FUR APPEARANCE
Page 277 of 4796
PALPEBRAL CLOSURE
RESPIRATORY RATE
NORMAL (80-110) 22 23 24 22 22 23
NORMAL 22 23 24 21 22 23
RALES - - - 1 - -
RED DEPOSITS - EYES

ABSENT 22 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
RED DEPOSITS - NOSE

ABSENT 22 23 24 22 22 23

ABSENT 22 23 24 22 22 23

ABSENT 22 23 24 22 22 23

PRESENT 1 - - - - -
Page 278 of 4796
ABSENT 21 23 24 22 22 23

ABSENT 22 23 24 22 22 23

PINK 22 23 24 22 22 23
EYE COLOR
PINK 22 23 24 22 22 23
SKIN COLOR
PINK 22 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
EYE PROMINENCE
NORMAL 22 23 23 22 22 23
EXOPHTHALMUS - - 1 - - -
MUSCLE TONE
MOBILITY
NORMAL 22 23 24 22 22 23
GAIT
Page 279 of 4796
NORMAL 22 23 24 22 22 23
CONVULSIONS-CLONIC
ABSENT 22 23 24 22 22 23
CONVULSIONS-TONIC
ABSENT 22 23 24 22 22 23
TREMORS
NONE 22 23 24 22 22 23
AROUSAL
NORMAL 21 23 24 22 20 23
SOMEWHAT HIGH 1 - - - 2 -
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NONE 22 23 24 22 22 23
PUPILLARY RESPONSE
ABSENT - - 1 1 - -
PRESENT 22 23 23 21 22 23
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 22 23 24 22 22 23
Page 280 of 4796
GROOMING COUNTS
MEAN 0.0 0.0 0.0 0.2 0.0 0.0
S.D. 0.00 0.00 0.00 0.66 0.00 0.00
N 22 23 24 22 22 23
URINATION COUNTS
MEAN 0.0 0.0 0.0 0.1 0.0 0.0
S.D. 0.21 0.21 0.00 0.35 0.21 0.00
N 22 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.21 0.00 0.00
N 22 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ASLEEP 2 2 3 2 4 4
ALERT 14 16 12 15 13 16
REARING - - 1 - - -

VERY EASY 23 23 23 21 20 22
EASY - - - 1 1 1
WITH VOCALIZATION - - - 1 1 1
Page 281 of 4796

LOW 23 23 23 22 21 23
LACRIMATION
NONE 23 23 22 22 21 23
SLIGHT - - 1 - - -
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
CHROMODACRYORRHEA
ABSENT 23 23 22 22 21 23
PRESENT - - 1 - - -
SALIVATION
NONE 23 23 23 22 21 23
PILOERECTION
NONE 23 23 23 22 21 23
FUR APPEARANCE
Page 282 of 4796
PALPEBRAL CLOSURE
RESPIRATORY RATE
NORMAL (80-110) 23 23 23 22 21 23
NORMAL 23 23 23 22 21 23
RED DEPOSITS - EYES

PRESENT 1 - 1 - - -
ABSENT 22 23 22 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
RED DEPOSITS - NOSE

PRESENT 1 1 4 2 1 -
ABSENT 22 22 19 20 20 23

ABSENT 23 23 23 22 21 23

ABSENT 23 23 23 22 21 23

Page 283 of 4796
ABSENT 23 23 23 22 21 23

PRESENT 1 - - - - -
ABSENT 22 23 23 22 21 23

PINK 22 23 23 22 21 23
PALE 1 - - - - -
EYE COLOR
PINK 23 23 23 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
SKIN COLOR
PINK 23 23 23 22 21 23
EYE PROMINENCE
NORMAL 23 23 23 22 21 23
MUSCLE TONE
MOBILITY
NORMAL 23 23 23 22 21 23
Page 284 of 4796
GAIT
NORMAL 23 23 23 22 21 23
CONVULSIONS-CLONIC
ABSENT 23 23 23 22 21 23
CONVULSIONS-TONIC
ABSENT 23 23 23 22 21 23
TREMORS
NONE 23 23 23 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
MALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
AROUSAL
NORMAL 22 23 23 22 21 23
SOMEWHAT HIGH 1 - - - - -
NONE 23 23 23 22 21 23
PUPILLARY RESPONSE
ABSENT 1 - - - - -
PRESENT 22 23 23 22 21 23
Page 285 of 4796
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 23 23 23 22 21 23
GROOMING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.21 0.00 0.00 0.00
N 23 23 23 22 21 23
URINATION COUNTS
MEAN 0.9 0.5 0.5 0.6 0.5 0.5
S.D. 0.97 0.59 0.90 0.95 0.75 0.90
N 23 23 23 22 21 23
DEFECATION COUNTS
MEAN 0.1 0.0 0.0 0.1 0.0 0.0
S.D. 0.63 0.00 0.00 0.29 0.00 0.00
N 23 23 23 22 21 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

ASLEEP 1 - - - - -
ALERT 18 20 21 20 19 18

VERY EASY 21 22 24 22 22 22
EASY 1 1 - - - 1
WITH VOCALIZATION 1 1 - - - 1

Page 286 of 4796
LOW 22 22 24 22 22 23
MODERATELY LOW - 1 - - - -
WITH VOCALIZATION - 1 - - - -
LACRIMATION
NONE 22 23 24 21 22 23
PRESENT - - - 1 - -
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
CHROMODACRYORRHEA
ABSENT 22 23 24 22 22 23
SALIVATION
NONE 22 23 24 22 22 23
PILOERECTION
NONE 22 23 24 22 22 23
FUR APPEARANCE
Page 287 of 4796
PALPEBRAL CLOSURE
RESPIRATORY RATE
NORMAL (80-110) 22 23 24 22 22 23
NORMAL 22 23 24 22 22 23
RED DEPOSITS - EYES

PRESENT - - - 1 - -
ABSENT 22 23 24 21 22 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
RED DEPOSITS - NOSE

PRESENT - - 1 - - -
ABSENT 22 23 23 22 22 23

ABSENT 22 23 24 22 22 23

ABSENT 22 23 24 22 22 23

Page 288 of 4796
ABSENT 22 23 24 22 22 23

ABSENT 22 23 24 22 22 23

PINK 22 23 24 22 22 23
EYE COLOR
PINK 22 23 24 22 22 23
SKIN COLOR
PINK 22 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
EYE PROMINENCE
NORMAL 22 23 24 22 22 23
MUSCLE TONE
MOBILITY
NORMAL 22 23 24 22 22 23
GAIT
NORMAL 22 23 24 22 22 23
Page 289 of 4796
CONVULSIONS-CLONIC
ABSENT 22 23 24 22 22 23
CONVULSIONS-TONIC
ABSENT 22 23 24 22 22 23
TREMORS
NONE 22 23 24 22 22 23
AROUSAL
NORMAL 22 23 22 22 22 22
SOMEWHAT HIGH - - 2 - - 1
-----------------------------------------------------------------------------------------------------------------------------------
FEMALES
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
NONE 22 23 24 22 22 23
PUPILLARY RESPONSE
PRESENT 22 23 24 22 22 23
BACKING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 22 23 24 22 22 23
Page 290 of 4796
GROOMING COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 22 23 24 22 22 23
URINATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.21 0.00 0.00
N 22 23 24 22 22 23
DEFECATION COUNTS
MEAN 0.0 0.0 0.0 0.0 0.0 0.0
S.D. 0.00 0.00 0.00 0.00 0.00 0.00
N 22 23 24 22 22 23
-----------------------------------------------------------------------------------------------------------------------------------
PFOBGv1.52
02/03/2009
R:07/13/2009
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS ACROSS SESSIONS - TOTAL COUNTS

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
Sex Interval Statistic __________ __________ __________ __________ __________ __________ ____________
P PND_013 Mean 1401 1250 1391 1330 2022 1331

S.D. 766.1 591.4 675.4 834.9 1721.4 654.1
S.E. of Mean 159.7 123.3 137.9 178.0 367.0 136.4
N (Litters) 23 23 24 22 22 23
LSMean 1403 1247 1391 1330 1930 1328
PND_017 Mean 2521 3679 2914 3405 3239 3057

S.D. 1293.8 1984.7 1703.6 1663.5 2504.3 1599.2
S.E. of Mean 269.8 413.8 347.8 354.7 533.9 333.5
N (Litters) 23 23 24 22 22 23
Page 291 of 4796
LSMean 2524 3676 2961 3405 3097 3055

PND_021 Mean 3045 3225 3033 2988 3139 2806

S.D. 1240.2 1710.1 936.2 1016.7 1048.7 1118.5
S.E. of Mean 258.6 356.6 191.1 216.8 223.6 233.2
N (Litters) 23 23 24 22 22 23
LSMean 3048 3223 3033 2988 3089 2803
Cumulative Mean 6967 8155 7338 7722 8400 7194

S.D. 2379.3 3214.3 2147.7 2430.6 4166.2 2256.0
S.E. of Mean 496.1 670.2 438.4 518.2 888.2 470.4
N (Litters) 23 23 24 22 22 23
Overall LSMean 2325 2715 2462 2574 2705 2395

Dunnett p-value# 0.434 0.979 0.816 0.475 0.999
Treatment*Session p-value# 0.246
Treatment*Sex*Session p-value# 0.525
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M PND_013 Mean 1069 1294 1378 1351 1775 1266

S.D. 498.1 1000.1 1023.2 836.6 1661.6 856.9
S.E. of Mean 103.9 208.5 208.9 178.4 362.6 178.7
N (Litters) 23 23 24 22 21 23
PND_017 Mean 2813 3200 2821 3225 2689 3242

S.D. 2001.1 2680.8 2109.4 1861.6 2930.1 2129.4
S.E. of Mean 417.2 559.0 430.6 396.9 639.4 444.0
N (Litters) 23 23 24 22 21 23
PND_021 Mean 3350 3097 3053 2683 2917 2970

Page 292 of 4796
S.D. 1724.6 2653.0 1261.7 977.4 1349.6 1323.8

S.E. of Mean 359.6 553.2 257.6 208.4 294.5 276.0
N (Litters) 23 23 24 22 21 23
Cumulative Mean 7231 7592 7252 7259 7381 7478

S.D. 3320.6 4755.7 3040.5 2323.6 3856.3 3216.4
S.E. of Mean 692.4 991.6 620.6 495.4 841.5 670.7
N (Litters) 23 23 24 22 21 23
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*SESSION interaction.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F PND_013 Mean 1732 1206 1404 1309 2050 1396

S.D. 1386.0 653.0 962.1 1022.7 1900.8 996.9
S.E. of Mean 289.0 136.1 196.4 218.0 405.3 207.9
N (Litters) 23 23 24 22 22 23
PND_017 Mean 2230 4158 3105 3584 3471 2873

S.D. 1472.8 2567.1 2083.8 2495.4 2808.4 2228.3
S.E. of Mean 307.1 535.3 434.5 532.0 598.7 464.6
N (Litters) 23 23 23 22 22 23
PND_021 Mean 2741 3353 3014 3292 3227 2641

Page 293 of 4796
S.D. 1183.8 1738.8 1554.8 1566.7 1288.3 1406.4

S.E. of Mean 246.8 362.6 317.4 334.0 274.7 293.3
N (Litters) 23 23 24 22 22 23
Cumulative Mean 6703 8717 7394 8185 8748 6910

S.D. 2897.2 3742.1 3509.8 3664.2 4393.8 3107.8
S.E. of Mean 604.1 780.3 716.4 781.2 936.8 648.0
N (Litters) 23 23 24 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*SESSION interaction.
SPONSOR:ACC SUMMARY OF MOTOR ACTIVITY COUNTS WITHIN SESSIONS - TOTAL COUNTS

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
Sex Session Interval Statistic __________ __________ __________ __________ __________ __________ ____________
P 00_10 PND_013 Mean 365 330 387 349 511 283

% Difference Control -9.6 6.0 -4.4 40.0 -22.5
S.D. 201.9 177.4 261.7 202.9 357.2 138.2
S.E. of Mean 42.1 37.0 53.4 43.3 76.2 28.8
N(Litters) 23 23 24 22 22 23
LSMean 366 329 387 349 496 282
11_20 Mean 257 239 242 208 350 202

% Difference Control -7.0 -5.8 -19.1 36.2 -21.4
S.D. 158.1 211.9 232.8 191.2 326.8 152.7
Page 294 of 4796
S.E. of Mean 33.0 44.2 47.5 40.8 69.7 31.8

N(Litters) 23 23 24 22 22 23
LSMean 258 238 242 208 332 201
21_30 Mean 217 159 223 176 291 210

S.D. 126.6 154.6 195.1 145.2 416.6 162.4
S.E. of Mean 26.4 32.2 39.8 30.9 88.8 33.9
N(Litters) 23 23 24 22 22 23
LSMean 218 158 223 176 258 209
31_40 Mean 187 141 199 162 271 217

S.D. 237.7 114.4 184.0 129.6 272.8 171.7
S.E. of Mean 49.6 23.9 37.6 27.6 58.2 35.8
N(Litters) 23 23 24 22 22 23
LSMean 188 140 199 162 258 216
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P 41_50 PND_013 Mean 183 172 156 193 309 232

S.D. 196.1 177.5 98.6 200.6 352.9 188.0
S.E. of Mean 40.9 37.0 20.1 42.8 75.2 39.2
N(Litters) 23 23 24 22 22 23
LSMean 184 171 156 193 294 231
51_60 Mean 192 210 185 242 291 186

S.D. 132.7 170.0 145.2 218.9 493.6 144.6
S.E. of Mean 27.7 35.4 29.6 46.7 105.2 30.2
N (Litters) 23 23 24 22 22 23
Page 295 of 4796
LSMean 193 209 185 242 300 185

Cumulative Mean 1401 1250 1391 1330 2022 1331

S.D. 766.1 591.4 675.4 834.9 1721.4 654.1
S.E. of Mean 159.7 123.3 137.9 178.0 367.0 136.4
N (Litters) 23 23 24 22 22 23
Overall LSMean 234 207 232 222 323 221

Dunnett p-value# 0.960 1.000 0.999 0.177 0.998
Treatment*Sex*Time p-value# 0.911
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M 00_10 PND_013 Mean 244 322 411 379 497 264

% Difference Control 32.0 68.4 55.3 103.7 8.2
S.D. 176.6 215.7 395.4 237.8 425.6 206.3
S.E. of Mean 36.8 45.0 80.7 50.7 92.9 43.0
N(Litters) 23 23 24 22 21 23
11_20 Mean 216 243 246 234 324 196

S.D. 205.4 310.3 283.4 218.9 453.1 168.2
S.E. of Mean 42.8 64.7 57.8 46.7 98.9 35.1
N(Litters) 23 23 24 22 21 23
Page 296 of 4796
21_30 Mean 180 128 200 190 223 195

% Difference Control -28.9 11.1 5.6 23.9 8.3
S.D. 113.5 102.8 223.1 147.0 377.4 194.3
S.E. of Mean 23.7 21.4 45.5 31.3 82.4 40.5
N(Litters) 23 23 24 22 21 23
31_40 Mean 115 154 146 164 242 226

S.D. 157.1 216.6 226.2 134.6 295.8 254.5
S.E. of Mean 32.8 45.2 46.2 28.7 64.5 53.1
N(Litters) 23 23 24 22 21 23
41_50 Mean 155 204 171 196 234 220

S.D. 113.0 362.0 161.7 218.0 295.2 266.7
S.E. of Mean 23.6 75.5 33.0 46.5 64.4 55.6
N(Litters) 23 23 24 22 21 23
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TIME interaction.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M 51_60 PND_013 Mean 158 243 205 188 255 166

S.D. 146.0 311.6 281.5 163.1 517.9 149.1
S.E. of Mean 30.5 65.0 57.5 34.8 113.0 31.1
N(Litters) 23 23 24 22 21 23
Cumulative Mean 1069 1294 1378 1351 1775 1266

S.D. 498.1 1000.1 1023.2 836.6 1661.6 856.9
S.E. of Mean 103.9 208.5 208.9 178.4 362.6 178.7
N(Litters) 23 23 24 22 21 23
Page 297 of 4796
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F 00_10 PND_013 Mean 485 338 362 320 487 303

S.D. 351.1 264.6 333.3 244.8 407.7 200.7
S.E. of Mean 73.2 55.2 68.0 52.2 86.9 41.8
N(Litters) 23 23 24 22 22 23
11_20 Mean 298 235 239 183 331 208

S.D. 248.2 304.0 388.1 267.9 386.4 279.6
S.E. of Mean 51.7 63.4 79.2 57.1 82.4 58.3
N(Litters) 23 23 24 22 22 23
Page 298 of 4796
21_30 Mean 253 189 247 161 284 225

S.D. 272.2 270.7 297.4 230.6 442.8 237.1
S.E. of Mean 56.8 56.4 60.7 49.2 94.4 49.4
N(Litters) 23 23 24 22 22 23
31_40 Mean 259 127 252 159 265 209

S.D. 433.3 113.0 303.5 165.1 385.8 195.4
S.E. of Mean 90.3 23.6 62.0 35.2 82.2 40.8
N(Litters) 23 23 24 22 22 23
41_50 Mean 212 140 141 190 346 245

S.D. 349.3 118.4 97.9 215.2 467.4 282.2
S.E. of Mean 72.8 24.7 20.0 45.9 99.7 58.8
N(Litters) 23 23 24 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F 51_60 PND_013 Mean 225 177 164 296 336 207

S.D. 245.9 143.7 149.1 339.2 513.8 235.5
S.E. of Mean 51.3 30.0 30.4 72.3 109.5 49.1
N(Litters) 23 23 24 22 22 23
Cumulative Mean 1732 1206 1404 1309 2050 1396

S.D. 1386.0 653.0 962.1 1022.7 1900.8 996.9
S.E. of Mean 289.0 136.1 196.4 218.0 405.3 207.9
N(Litters) 23 23 24 22 22 23
Page 299 of 4796
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P 00_10 PND_017 Mean 1057 1383 1168 1289 1253 1137

S.D. 328.0 448.7 448.1 415.1 335.6 418.0
S.E. of Mean 68.4 93.6 91.5 88.5 71.6 87.2
N(Litters) 23 23 24 22 22 23
LSMean 1056 1384 1181 1289 1257 1138
11_20 Mean 449 597 491 496 470 558

S.D. 306.8 332.4 409.2 377.3 401.6 360.4
Page 300 of 4796
S.E. of Mean 64.0 69.3 83.5 80.4 85.6 75.1

N(Litters) 23 23 24 22 22 23
LSMean 447 598 501 496 449 559
21_30 Mean 234 484 350 346 388 378

S.D. 257.1 352.0 356.1 293.7 490.5 317.4
S.E. of Mean 53.6 73.4 72.7 62.6 104.6 66.2
N(Litters) 23 23 24 22 22 23
LSMean 233 485 354 346 362 379
31_40 Mean 204 406 250 366 341 343

S.D. 226.1 418.4 323.3 362.3 489.2 382.8
S.E. of Mean 47.1 87.2 66.0 77.2 104.3 79.8
N(Litters) 23 23 24 22 22 23
LSMean 203 408 253 366 315 344
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P 41_50 PND_017 Mean 262 387 327 432 358 316

S.D. 285.7 417.5 353.8 396.4 548.9 288.4
S.E. of Mean 59.6 87.1 72.2 84.5 117.0 60.1
N(Litters) 23 23 24 22 22 23
LSMean 261 388 332 432 327 317
51_60 Mean 315 422 328 475 429 326

S.D. 303.6 485.6 303.6 385.0 598.8 338.6
S.E. of Mean 63.3 101.3 62.0 82.1 127.7 70.6
N(Litters) 23 23 24 22 22 23
Page 301 of 4796
LSMean 314 423 332 475 391 327

Cumulative Mean 2521 3679 2914 3405 3239 3057

S.E. of Mean 269.8 413.8 347.8 354.7 533.9 333.5
S.D. 1293.8 1984.7 1703.6 1663.5 2504.3 1599.2
N(Litters) 23 23 24 22 22 23
Overall LSMean 419 614 492 567 517 511

Dunnett p-value# 0.094 0.859 0.298 0.687 0.725
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M 00_10 PND_017 Mean 1106 1305 1041 1286 1197 1204

% Difference Control 18.0 -5.9 16.3 8.2 8.9
S.D. 383.9 497.8 565.9 631.0 549.6 604.5
S.E. of Mean 80.0 103.8 115.5 134.5 119.9 126.0
N(Litters) 23 23 24 22 21 23
11_20 Mean 517 529 430 461 289 596

% Difference Control 2.3 -16.8 -10.8 -44.1 15.3
S.D. 484.2 454.0 419.9 435.3 427.0 560.2
S.E. of Mean 101.0 94.7 85.7 92.8 93.2 116.8
N(Litters) 23 23 24 22 21 23
Page 302 of 4796
21_30 Mean 293 364 355 274 304 356

% Difference Control 24.2 21.2 -6.5 3.8 21.5
S.D. 429.1 510.1 428.8 348.3 639.6 406.1
S.E. of Mean 89.5 106.4 87.5 74.3 139.6 84.7
N(Litters) 23 23 24 22 21 23
31_40 Mean 217 283 267 310 304 393

S.D. 388.0 677.7 420.0 341.4 637.4 522.7
S.E. of Mean 80.9 141.3 85.7 72.8 139.1 109.0
N(Litters) 23 23 24 22 21 23
41_50 Mean 296 343 348 421 285 350

S.D. 410.1 579.0 510.8 475.5 585.0 472.8
S.E. of Mean 85.5 120.7 104.3 101.4 127.7 98.6
N(Litters) 23 23 24 22 21 23
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M 51_60 PND_017 Mean 384 376 380 474 310 343

S.D. 498.4 619.6 446.0 516.8 560.7 530.3
S.E. of Mean 103.9 129.2 91.0 110.2 122.4 110.6
N(Litters) 23 23 24 22 21 23
Cumulative Mean 2813 3200 2821 3225 2689 3242

% Difference Control 13.8 0.3 14.6 -4.4 15.3
S.D. 2001.1 2680.8 2109.4 1861.6 2930.1 2129.4
S.E. of Mean 417.2 559.0 430.6 396.9 639.4 444.0
N(Litters) 23 23 24 22 21 23
Page 303 of 4796
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F 00_10 PND_017 Mean 1008 1461 1325 1292 1309 1070

S.D. 403.9 577.4 605.2 507.5 573.7 549.9
S.E. of Mean 84.2 120.4 126.2 108.2 122.3 114.7
N(Litters) 23 23 23 22 22 23
11_20 Mean 380 665 575 531 603 520

S.D. 354.5 565.9 524.8 484.3 533.5 450.8
S.E. of Mean 73.9 118.0 109.4 103.3 113.8 94.0
N(Litters) 23 23 23 22 22 23
Page 304 of 4796
21_30 Mean 176 604 357 419 414 401

S.D. 261.4 485.5 515.5 497.2 553.6 498.7
S.E. of Mean 54.5 101.2 107.5 106.0 118.0 104.0
N(Litters) 23 23 23 22 22 23
31_40 Mean 192 530 242 423 318 292

S.D. 320.7 541.2 398.1 553.2 503.0 414.7
S.E. of Mean 66.9 112.8 83.0 117.9 107.2 86.5
N(Litters) 23 23 23 22 22 23
41_50 Mean 228 431 319 443 363 282

S.D. 430.5 527.1 444.6 588.8 666.0 373.7
S.E. of Mean 89.8 109.9 92.7 125.5 142.0 77.9
N(Litters) 23 23 23 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F 51_60 PND_017 Mean 246 468 287 476 464 309

S.D. 401.7 637.0 407.7 603.7 682.8 472.4
S.E. of Mean 83.8 132.8 85.0 128.7 145.6 98.5
N(Litters) 23 23 23 22 22 23
Cumulative Mean 2230 4158 3105 3584 3471 2873

S.D. 1472.8 2567.1 2083.8 2495.4 2808.4 2228.3
S.E. of Mean 307.1 535.3 434.5 532.0 598.7 464.6
N(Litters) 23 23 23 22 22 23
Page 305 of 4796
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P 00_10 PND_021 Mean 1482 1614 1512 1506 1470 1421

S.D. 368.6 430.3 222.5 283.7 193.0 374.1
S.E. of Mean 76.9 89.7 45.4 60.5 41.2 78.0
N(Litters) 23 23 24 22 22 23
LSMean 1482 1614 1512 1506 1476 1422
11_20 Mean 586 641 520 533 572 489

S.D. 302.9 427.6 245.6 216.7 222.1 227.5
Page 306 of 4796
S.E. of Mean 63.2 89.2 50.1 46.2 47.4 47.4

N(Litters) 23 23 24 22 22 23
LSMean 586 641 520 533 563 489
21_30 Mean 375 360 323 288 375 286

S.D. 236.8 338.0 228.1 247.2 264.7 251.7
S.E. of Mean 49.4 70.5 46.6 52.7 56.4 52.5
N(Litters) 23 23 24 22 22 23
LSMean 374 361 323 288 364 286
31_40 Mean 249 251 298 217 281 284

S.D. 239.2 299.9 237.8 214.7 256.9 274.1
S.E. of Mean 49.9 62.5 48.5 45.8 54.8 57.1
N(Litters) 23 23 24 22 22 23
LSMean 248 251 297 217 266 284
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P 41_50 PND_021 Mean 167 179 220 211 240 151

S.D. 212.1 224.8 228.7 224.3 265.1 166.1
S.E. of Mean 44.2 46.9 46.7 47.8 56.5 34.6
N(Litters) 23 23 24 22 22 23
LSMean 166 179 220 210 227 152
51_60 Mean 187 181 161 234 201 175

S.D. 217.4 274.2 188.2 254.2 252.1 189.7
S.E. of Mean 45.3 57.2 38.4 54.2 53.7 39.6
N(Litters) 23 23 24 22 22 23
Page 307 of 4796
LSMean 187 181 161 234 192 176

Cumulative Mean 3045 3225 3033 2988 3139 2806

% Difference Control 5.9 -0.4 -1.9 3.1 -7.8
S.D. 1240.2 1710.1 936.2 1016.7 1048.7 1118.5
S.E. of Mean 258.6 356.6 191.1 216.8 223.6 233.2
N(Litters) 23 23 24 22 22 23
Overall LSMean 507 538 506 498 515 468

Dunnett p-value# 0.982 1.000 1.000 1.000 0.950
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M 00_10 PND_021 Mean 1472 1617 1538 1535 1508 1444

S.D. 541.7 547.6 369.2 476.4 341.0 401.3
S.E. of Mean 113.0 114.2 75.4 101.6 74.4 83.7
N(Litters) 23 23 24 22 21 23
11_20 Mean 652 616 555 527 504 555

S.D. 391.9 630.4 360.2 302.8 321.0 312.3
S.E. of Mean 81.7 131.4 73.5 64.6 70.1 65.1
N(Litters) 23 23 24 22 21 23
Page 308 of 4796
21_30 Mean 416 356 332 232 308 273

S.D. 324.9 514.2 298.9 268.4 330.9 288.5
S.E. of Mean 67.8 107.2 61.0 57.2 72.2 60.1
N(Litters) 23 23 24 22 21 23
31_40 Mean 298 196 270 120 244 346

S.D. 348.9 475.5 291.1 165.3 273.4 422.1
S.E. of Mean 72.7 99.2 59.4 35.2 59.7 88.0
N(Litters) 23 23 24 22 21 23
41_50 Mean 236 148 217 106 169 168

S.D. 342.2 314.4 280.8 186.4 276.6 255.3
S.E. of Mean 71.4 65.6 57.3 39.8 60.4 53.2
N(Litters) 23 23 24 22 21 23
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M 51_60 PND_021 Mean 275 164 140 164 184 185

S.D. 361.1 425.4 250.1 281.0 321.2 311.1
S.E. of Mean 75.3 88.7 51.1 59.9 70.1 64.9
N(Litters) 23 23 24 22 21 23
Cumulative Mean 3350 3097 3053 2683 2917 2970

S.D. 1724.6 2653.0 1261.7 977.4 1349.6 1323.8
S.E. of Mean 359.6 553.2 257.6 208.4 294.5 276.0
N(Litters) 23 23 24 22 21 23
Page 309 of 4796
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F 00_10 PND_021 Mean 1491 1611 1486 1477 1439 1399

S.D. 341.0 432.2 294.8 206.9 279.1 481.0
S.E. of Mean 71.1 90.1 60.2 44.1 59.5 100.3
N(Litters) 23 23 24 22 22 23
11_20 Mean 521 665 484 539 616 422

S.D. 355.4 364.3 341.1 265.3 260.0 347.7
S.E. of Mean 74.1 76.0 69.6 56.6 55.4 72.5
N(Litters) 23 23 24 22 22 23
Page 310 of 4796
21_30 Mean 333 364 313 344 414 298

S.D. 318.0 428.2 410.3 354.7 342.3 335.2
S.E. of Mean 66.3 89.3 83.7 75.6 73.0 69.9
N(Litters) 23 23 24 22 22 23
31_40 Mean 199 306 325 314 283 222

S.D. 280.4 412.9 434.7 393.0 336.3 266.2
S.E. of Mean 58.5 86.1 88.7 83.8 71.7 55.5
N(Litters) 23 23 24 22 22 23
41_50 Mean 98 210 222 315 280 135

S.D. 230.5 331.7 362.7 409.9 356.8 256.0
S.E. of Mean 48.1 69.2 74.0 87.4 76.1 53.4
N(Litters) 23 23 24 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F 51_60 PND_021 Mean 100 198 183 304 195 165

S.D. 151.6 351.1 313.4 398.4 301.6 288.9
S.E. of Mean 31.6 73.2 64.0 84.9 64.3 60.2
N(Litters) 23 23 24 22 22 23
Cumulative Mean 2741 3353 3014 3292 3227 2641

S.D. 1183.8 1738.8 1554.8 1566.7 1288.3 1406.4
S.E. of Mean 246.8 362.6 317.4 334.0 274.7 293.3
N(Litters) 23 23 24 22 22 23
Page 311 of 4796
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P 00_10 PND_061 Mean 1696 1745 1714 1724 1667 1727

S.D. 314.2 347.9 295.8 306.9 358.6 303.6
S.E. of Mean 46.8 51.3 43.1 46.3 54.7 44.8
N 45 46 47 44 43 46
11_20 Mean 1170 1174 1176 1178 1216 1193

S.D. 258.3 317.0 281.2 325.5 325.8 266.6
S.E. of Mean 38.5 46.7 41.0 49.1 49.7 39.3
N 45 46 47 44 43 46
Page 312 of 4796
21_30 Mean 857 875 812 858 881 854

S.D. 221.7 289.5 282.7 268.2 344.8 313.4
S.E. of Mean 33.1 42.7 41.2 40.4 52.6 46.2
N 45 46 47 44 43 46
31_40 Mean 722 746 691 642 713 689

S.D. 299.4 392.2 357.6 289.4 368.8 364.0
S.E. of Mean 44.6 57.8 52.2 43.6 56.2 53.7
N 45 46 47 44 43 46
41_50 Mean 620 657 532 588 597 471

S.D. 348.2 373.0 392.8 375.8 392.0 362.4
S.E. of Mean 51.9 55.0 57.3 56.6 59.8 53.4
N 45 46 47 44 43 46
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P 51_60 PND_061 Mean 488 488 423 444 499 396

S.D. 340.6 314.3 302.1 368.6 364.0 299.9
S.E. of Mean 50.8 46.3 44.1 55.6 55.5 44.2
N 45 46 47 44 43 46
Cumulative Mean 5553 5686 5349 5434 5573 5330

S.D. 1237.2 1373.6 1156.6 1434.9 1485.1 1206.8
S.E. of Mean 184.4 202.5 168.7 216.3 226.5 177.9
N 45 46 47 44 43 46
Page 313 of 4796

-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M 00_10 PND_061 Mean 1529 1642 1559 1594 1485 1583

S.D. 245.2 304.5 292.5 300.4 234.9 207.9
S.E. of Mean 51.1 63.5 61.0 64.1 51.3 43.3
N 23 23 23 22 21 23
LSMean 1527 1645 1561 1594 1488 1585
11_20 Mean 1103 1104 1074 1126 1064 1192

% Difference Control 0.1 -2.6 2.1 -3.5 8.1
S.D. 204.3 275.4 206.1 312.4 206.3 221.6
Page 314 of 4796
S.E. of Mean 42.6 57.4 43.0 66.6 45.0 46.2

N 23 23 23 22 21 23
LSMean 1101 1106 1076 1126 1066 1194
21_30 Mean 830 832 819 814 802 852

% Difference Control 0.2 -1.3 -1.9 -3.4 2.7
S.D. 174.6 196.5 304.5 242.5 319.1 323.1
S.E. of Mean 36.4 41.0 63.5 51.7 69.6 67.4
N 23 23 23 22 21 23
LSMean 828 834 821 814 805 854
31_40 Mean 723 703 666 681 663 617

S.D. 315.4 291.6 314.6 218.8 319.9 360.1
S.E. of Mean 65.8 60.8 65.6 46.6 69.8 75.1
N 23 23 23 22 21 23
LSMean 721 705 668 681 665 619
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M 41_50 PND_061 Mean 623 661 618 569 605 448

S.D. 279.8 345.5 419.4 284.6 326.7 325.5
S.E. of Mean 58.3 72.0 87.5 60.7 71.3 67.9
N 23 23 23 22 21 23
LSMean 620 663 620 569 607 450
51_60 Mean 533 526 497 445 468 337

S.D. 338.7 342.6 297.1 326.5 323.5 307.0
S.E. of Mean 70.6 71.4 62.0 69.6 70.6 64.0
N 23 23 23 22 21 23
Page 315 of 4796
LSMean 531 528 499 445 470 339

Cumulative Mean 5342 5468 5234 5228 5088 5029

S.D. 940.4 1132.2 1299.2 1295.8 1196.0 1184.1
S.E. of Mean 196.1 236.1 270.9 276.3 261.0 246.9
N 23 23 23 22 21 23
Overall LSMean 888 913 874 871 850 840

Dunnett p-value# 0.990 0.999 0.998 0.948 0.866
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F 00_10 PND_061 Mean 1870 1848 1862 1854 1840 1872

% Difference Control -1.2 -0.4 -0.9 -1.6 0.1
S.D. 285.6 364.3 215.2 258.9 374.4 318.7
S.E. of Mean 60.9 76.0 43.9 55.2 79.8 66.4
N 22 23 24 22 22 23
LSMean 1870 1848 1862 1854 1840 1871
11_20 Mean 1240 1244 1274 1231 1361 1193

% Difference Control 0.3 2.7 -0.7 9.8 -3.8
S.D. 293.3 345.6 311.7 337.1 355.8 310.3
Page 316 of 4796
S.E. of Mean 62.5 72.1 63.6 71.9 75.9 64.7

N 22 23 24 22 22 23
LSMean 1240 1243 1274 1231 1361 1193
21_30 Mean 885 918 805 901 956 856

S.D. 263.6 359.0 266.5 290.5 358.6 310.6
S.E. of Mean 56.2 74.9 54.4 61.9 76.5 64.8
N 22 23 24 22 22 23
LSMean 885 918 805 901 956 855
31_40 Mean 720 789 716 603 761 761

S.D. 289.0 475.1 399.7 347.1 411.8 361.2
S.E. of Mean 61.6 99.1 81.6 74.0 87.8 75.3
N 22 23 24 22 22 23
LSMean 720 789 716 603 761 760
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F 41_50 PND_061 Mean 618 653 450 608 589 494

S.D. 414.8 406.4 354.7 455.3 453.4 402.0
S.E. of Mean 88.4 84.7 72.4 97.1 96.7 83.8
N 22 23 24 22 22 23
LSMean 618 652 450 608 589 494
51_60 Mean 440 451 353 442 529 455

S.D. 343.7 286.0 295.6 414.1 404.2 287.0
S.E. of Mean 73.3 59.6 60.3 88.3 86.2 59.8
N 22 23 24 22 22 23
Page 317 of 4796
LSMean 440 450 353 442 529 454

Cumulative Mean 5773 5903 5459 5639 6037 5632

S.D. 1476.8 1574.3 1017.4 1564.8 1608.7 1177.5
S.E. of Mean 314.8 328.3 207.7 333.6 343.0 245.5
N 22 23 24 22 22 23
Overall LSMean 962 983 910 940 1006 938

Dunnett p-value# 0.998 0.911 0.998 0.958 0.997
-------------------------------------------------------------------------------------------------------------------------------------
SPONSOR:ACC SUMMARY OF STARTLE RESPONSE DATA MAX [NEWTONS]

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P PND_20 00_10 Mean 2.194 2.274 2.057 2.293 2.169 1.774
S.D. 0.8597 0.8541 0.6588 0.6015 0.7840 0.3240
S.E. of Mean 0.1793 0.1781 0.1345 0.1282 0.1671 0.0676
N (Litters) 23 23 24 22 22 23
LSMean 2.203 2.265 2.075 2.293 2.184 1.757
11_20 Mean 1.809 1.855 1.771 1.968 1.928 1.610

S.D. 0.6449 0.6535 0.5911 0.5491 0.6909 0.3192
S.E. of Mean 0.1345 0.1363 0.1207 0.1171 0.1473 0.0665
Page 318 of 4796
N (Litters) 23 23 24 22 22 23
LSMean 1.818 1.846 1.779 1.968 1.937 1.592
21_30 Mean 1.644 1.648 1.592 1.873 1.793 1.470

S.D. 0.6286 0.5323 0.4856 0.7939 0.6930 0.4168
S.E. of Mean 0.1311 0.1110 0.0991 0.1693 0.1477 0.0869
N (Litters) 23 23 24 22 22 23
LSMean 1.652 1.640 1.596 1.873 1.811 1.456
31_40 Mean 1.564 1.558 1.526 1.626 1.717 1.455

% Difference Control -0.4 -2.4 4.0 9.8 -7.0
S.D. 0.5799 0.4314 0.4745 0.6712 0.6451 0.3625
S.E. of Mean 0.1209 0.0900 0.0969 0.1431 0.1375 0.0756
N (Litters) 23 23 24 22 22 23
LSMean 1.573 1.549 1.537 1.626 1.736 1.440
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P PND_20 41_50 Mean 1.499 1.603 1.492 1.664 1.650 1.317

S.D. 0.5974 0.5700 0.5233 0.5109 0.6542 0.3658
S.E. of Mean 0.1246 0.1189 0.1068 0.1089 0.1395 0.0763
N (Litters) 23 23 24 22 22 23
LSMean 1.508 1.594 1.493 1.664 1.656 1.300
Overall LSMean 1.751 1.779 1.696 1.885 1.865 1.509

Dunnett p-value# 1.000 0.995 0.816 0.895 0.308
Page 319 of 4796
Treatment*Trial p-value# 0.650

Treatment*Sex*Trial p-value# 0.450
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M PND_20 00_10 Mean 2.412 2.374 2.018 2.226 2.182 1.666

S.D. 1.0269 1.1669 0.9957 1.0325 0.9167 0.4552
S.E. of Mean 0.2141 0.2433 0.2076 0.2201 0.2000 0.0970
N (Litters) 23 23 23 22 21 22
11_20 Mean 1.913 1.887 1.678 1.925 1.933 1.601

S.D. 0.8369 0.7853 0.7386 0.8584 0.6896 0.4585
S.E. of Mean 0.1745 0.1638 0.1540 0.1830 0.1505 0.0977
N (Litters) 23 23 23 22 21 22
Page 320 of 4796
21_30 Mean 1.784 1.660 1.530 1.750 1.879 1.506

S.D. 0.7608 0.7605 0.5838 1.0146 0.9763 0.5928
S.E. of Mean 0.1586 0.1586 0.1217 0.2163 0.2130 0.1264
N (Litters) 23 23 23 22 21 22
31_40 Mean 1.750 1.609 1.555 1.537 1.658 1.443

S.D. 0.6183 0.6427 0.5834 0.9002 0.7497 0.5467
S.E. of Mean 0.1289 0.1340 0.1217 0.1919 0.1636 0.1166
N (Litters) 23 23 23 22 21 22
41_50 Mean 1.600 1.781 1.513 1.710 1.538 1.223

S.D. 0.6819 0.8059 0.7808 0.8313 0.7519 0.4032
S.E. of Mean 0.1422 0.1680 0.1628 0.1772 0.1641 0.0860
N (Litters) 23 23 23 22 21 22
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TRIAL interaction.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F PND_20 00_10 Mean 1.977 2.174 2.128 2.361 2.204 1.872

S.D. 0.8459 0.7907 0.6122 0.7714 0.9928 0.5876
S.E. of Mean 0.1764 0.1649 0.1250 0.1645 0.2117 0.1225
N (Litters) 23 23 24 22 22 23
11_20 Mean 1.706 1.823 1.875 2.011 1.959 1.606

S.D. 0.7422 0.6873 0.6390 0.5658 1.0238 0.5887
S.E. of Mean 0.1548 0.1433 0.1304 0.1206 0.2183 0.1228
N (Litters) 23 23 24 22 22 23
Page 321 of 4796
21_30 Mean 1.504 1.636 1.656 1.996 1.761 1.428

S.D. 0.7531 0.6248 0.5685 0.8019 0.9512 0.6737
S.E. of Mean 0.1570 0.1303 0.1161 0.1710 0.2028 0.1405
N (Litters) 23 23 24 22 22 23
31_40 Mean 1.379 1.507 1.514 1.715 1.833 1.459

S.D. 0.6732 0.5881 0.5764 0.6803 1.0180 0.5628
S.E. of Mean 0.1404 0.1226 0.1177 0.1450 0.2170 0.1174
N (Litters) 23 23 24 22 22 23
41_50 Mean 1.399 1.426 1.468 1.619 1.792 1.399

S.D. 0.7120 0.5956 0.5933 0.5146 0.9290 0.6022
S.E. of Mean 0.1485 0.1242 0.1211 0.1097 0.1981 0.1256
N (Litters) 23 23 24 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P PND_60 00_10 Mean 2.415 2.301 2.072 3.021 2.165 2.038
% Difference Control -4.7 -14.2 25.1 -10.4 -15.6
S.D. 1.7938 1.3884 1.1180 2.3208 1.7647 1.0727
S.E. of Mean 0.2704 0.2047 0.1631 0.3499 0.2691 0.1582
N 44 46 47 44 43 46
LSMean 2.392 2.308 2.077 3.021 2.167 2.045
11_20 Mean 1.796 1.624 1.605 2.149 1.454 1.375

S.D. 1.2816 0.9790 1.0032 1.7252 1.1706 0.7835
S.E. of Mean 0.1932 0.1443 0.1463 0.2601 0.1785 0.1155
Page 322 of 4796
N 44 46 47 44 43 46
LSMean 1.782 1.631 1.608 2.149 1.455 1.382
21_30 Mean 1.431 1.393 1.333 1.571 1.277 1.196

S.D. 1.1176 0.9616 0.9972 0.9863 1.0425 0.6765
S.E. of Mean 0.1685 0.1418 0.1455 0.1487 0.1590 0.0998
N 44 46 47 44 43 46
LSMean 1.416 1.400 1.336 1.571 1.279 1.203
31_40 Mean 1.342 1.310 1.214 1.438 1.136 1.118

S.D. 1.0247 0.8015 0.9902 0.9074 0.8192 0.7246
S.E. of Mean 0.1545 0.1182 0.1444 0.1368 0.1249 0.1068
N 44 46 47 44 43 46
LSMean 1.329 1.317 1.216 1.438 1.140 1.125
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P PND_60 41_50 Mean 1.231 1.206 1.103 1.274 1.172 1.048

S.D. 0.8352 0.7237 0.6430 0.6791 0.8433 0.6372
S.E. of Mean 0.1259 0.1067 0.0938 0.1024 0.1286 0.0939
N 44 46 47 44 43 46
LSMean 1.222 1.213 1.108 1.274 1.176 1.055
Overall LSMean 1.629 1.574 1.469 1.891 1.444 1.362

Dunnett p-value# 0.999 0.879 0.540 0.817 0.513
Page 323 of 4796

-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M PND_60 00_10 Mean 2.892 2.368 2.156 3.275 2.089 2.334

S.D. 2.0506 1.5852 1.1611 2.8117 1.5816 1.1157
S.E. of Mean 0.4276 0.3305 0.2421 0.5995 0.3451 0.2326
N 23 23 23 22 21 23
11_20 Mean 2.094 1.590 1.567 2.251 1.351 1.399

S.D. 1.5223 1.0783 1.0885 2.0021 0.7936 0.8690
S.E. of Mean 0.3174 0.2248 0.2270 0.4268 0.1732 0.1812
N 23 23 23 22 21 23
Page 324 of 4796
21_30 Mean 1.741 1.452 1.291 1.482 1.192 1.276

S.D. 1.1737 1.1769 1.1005 0.9675 0.6684 0.7941
S.E. of Mean 0.2447 0.2454 0.2295 0.2063 0.1458 0.1656
N 23 23 23 22 21 23
31_40 Mean 1.627 1.355 1.148 1.332 1.178 1.205

S.D. 1.1871 0.9573 0.7939 0.6887 0.8184 0.8348
S.E. of Mean 0.2475 0.1996 0.1655 0.1468 0.1786 0.1741
N 23 23 23 22 21 23
41_50 Mean 1.425 1.272 1.146 1.227 1.169 1.163

S.D. 1.0010 0.8773 0.6677 0.5979 0.8203 0.7873
S.E. of Mean 0.2087 0.1829 0.1392 0.1275 0.1790 0.1642
N 23 23 23 22 21 23
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F PND_60 00_10 Mean 1.892 2.234 1.991 2.767 2.238 1.742

S.D. 1.3204 1.1920 1.0937 1.7287 1.9583 0.9620
S.E. of Mean 0.2881 0.2486 0.2233 0.3686 0.4175 0.2006
N 21 23 24 22 22 23
11_20 Mean 1.470 1.658 1.641 2.047 1.552 1.351

S.D. 0.8764 0.8917 0.9363 1.4368 1.4561 0.7068
S.E. of Mean 0.1913 0.1859 0.1911 0.3063 0.3104 0.1474
N 21 23 24 22 22 23
Page 325 of 4796
21_30 Mean 1.090 1.334 1.374 1.659 1.357 1.116

S.D. 0.9681 0.7064 0.9094 1.0196 1.3169 0.5405
S.E. of Mean 0.2113 0.1473 0.1856 0.2174 0.2808 0.1127
N 21 23 24 22 22 23
31_40 Mean 1.030 1.265 1.277 1.545 1.095 1.030

S.D. 0.7152 0.6271 1.1616 1.0898 0.8371 0.6009
S.E. of Mean 0.1561 0.1308 0.2371 0.2323 0.1785 0.1253
N 21 23 24 22 22 23
41_50 Mean 1.019 1.139 1.062 1.321 1.176 0.934

S.D. 0.5542 0.5408 0.6300 0.7631 0.8840 0.4278
S.E. of Mean 0.1209 0.1128 0.1286 0.1627 0.1885 0.0892
N 21 23 24 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------
TABLE 43 (F1 PND 22 - SUBSET B)
PROJECT NO.:WIL-186056W DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SPONSOR:ACC SUMMARY OF BIEL MAZE SWIM TRIALS - MEAN NUMBER OF ERRORS

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
Sex Trial Statistic __________ __________ __________ __________ __________ __________ ____________
P 1 (Path A) Mean 16 14 15 19 16 14
S.D. 6.6 6.0 7.4 9.9 6.6 8.5
S.E. of Mean 1.4 1.3 1.5 2.1 1.4 1.8
N (Litters) 23 23 23 22 22 23
LSMean 16 14 15 19 16 14
2 (Path A) Mean 13 12 14 15 11 16
% Difference Control -7.7 7.7 15.4 -15.4 23.1
S.D. 8.2 7.3 7.6 7.8 7.3 8.0
S.E. of Mean 1.7 1.5 1.6 1.7 1.6 1.7
Page 326 of 4796
N (Litters) 23 23 23 22 22 23
LSMean 13 12 14 15 11 16
3 (Path A) Mean 11 16 13 13 15 14
S.D. 8.0 9.0 9.4 10.3 6.8 8.6
S.E. of Mean 1.7 1.9 2.0 2.2 1.4 1.8
N (Litters) 23 23 23 22 22 23
LSMean 11 16 14 13 14 14
4 (Path A) Mean 10 12 9 10 10 9
S.D. 8.3 7.4 5.8 6.1 8.3 5.7
S.E. of Mean 1.7 1.5 1.2 1.3 1.8 1.2
N (Litters) 23 23 23 22 22 23
LSMean 10 12 9 10 10 9
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P Overall LSMean 13 13 13 14 13 13
(Path A) Dunnett p-value# 0.962 1.000 0.451 1.000 0.981
Page 327 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M 1 (Path A) Mean 16 14 17 16 14 14
% Difference Control -12.5 6.3 0.0 -12.5 -12.5
S.D. 11.7 9.8 11.2 11.3 10.2 11.3
S.E. of Mean 2.4 2.1 2.3 2.4 2.2 2.3
N (Litters) 23 23 23 22 21 23
2 (Path A) Mean 9 13 15 15 10 19
S.D. 7.8 12.4 10.0 11.9 8.0 12.3
S.E. of Mean 1.6 2.6 2.1 2.5 1.8 2.6
N (Litters) 23 23 23 22 21 23
Page 328 of 4796
3 (Path A) Mean 10 16 14 12 12 15
S.D. 10.1 13.1 13.0 11.3 9.5 12.5
S.E. of Mean 2.1 2.7 2.8 2.4 2.1 2.6
N (Litters) 23 23 22 22 21 23
4 (Path A) Mean 11 9 7 15 12 10
S.D. 13.7 7.8 6.1 11.4 14.5 8.8
S.E. of Mean 2.9 1.6 1.3 2.4 3.2 1.8
N (Litters) 23 23 22 22 21 23
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed due to lack of a statistically significant TRT*SEX or TRT*SEX*TRIAL interaction

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F 1 (Path A) Mean 17 14 13 22 17 13
S.D. 12.3 8.2 10.3 13.9 8.0 11.0
S.E. of Mean 2.6 1.7 2.2 3.0 1.7 2.3
N (Litters) 23 23 23 22 22 23
2 (Path A) Mean 16 11 13 16 13 14
S.D. 13.4 9.4 9.9 13.4 13.6 9.8
S.E. of Mean 2.8 2.0 2.1 2.9 2.9 2.0
N (Litters) 23 23 23 22 22 23
Page 329 of 4796
3 (Path A) Mean 13 16 13 14 17 14
S.D. 10.2 12.0 11.6 15.3 11.8 11.7
S.E. of Mean 2.1 2.5 2.4 3.3 2.5 2.4
N (Litters) 23 23 23 22 22 23
4 (Path A) Mean 9 14 10 6 8 8
S.D. 8.4 12.8 8.2 6.0 8.5 6.8
S.E. of Mean 1.8 2.7 1.7 1.3 1.8 1.4
N (Litters) 23 23 23 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P 5 (Path B) Mean 36 32 33 33 32 32
S.D. 7.1 9.7 11.6 9.6 10.5 8.8
S.E. of Mean 1.5 2.0 2.4 2.1 2.2 1.8
N (Litters) 23 23 23 22 22 23
6 (Path B) Mean 32 29 27 26 27 25
S.D. 8.9 10.3 12.8 9.6 11.3 8.9
S.E. of Mean 1.9 2.2 2.7 2.0 2.4 1.9
N (Litters) 23 23 23 22 22 23
Page 330 of 4796
7 (Path B) Mean 28 24 26 24 23 21
S.D. 10.4 12.5 13.3 12.0 10.7 12.6
S.E. of Mean 2.2 2.6 2.8 2.6 2.3 2.6
N (Litters) 23 23 23 22 22 23
8 (Path B) Mean 20 21 27 17 18 16
S.D. 7.6 10.4 12.7 9.1 11.0 10.2
S.E. of Mean 1.6 2.2 2.7 1.9 2.4 2.1
N (Litters) 23 23 23 22 22 23
9 (Path B) Mean 21 17 24 11 18 18
% Difference Control -19.0 14.3 -47.6 -14.3 -14.3
S.D. 11.9 12.1 13.5 8.0 11.8 12.9
S.E. of Mean 2.5 2.5 2.8 1.7 2.5 2.7
N (Litters) 23 23 23 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P 10 (Path B) Mean 13 13 15 9 12 13
% Difference Control 0.0 15.4 -30.8 -7.7 0.0
S.D. 10.4 9.4 10.4 6.8 7.9 13.5
S.E. of Mean 2.2 2.0 2.2 1.4 1.7 2.8
N (Litters) 23 23 23 22 22 23
Overall Treatment*Sex p-value# 0.016*

(Path B) Treatment*Sex*Trial p-value# 0.643
Page 331 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M 5 (Path B) Mean 34 32 34 34 33 37
S.D. 11.8 14.6 14.5 14.5 13.8 11.7
S.E. of Mean 2.5 3.0 3.1 3.1 3.0 2.5
N (Litters) 23 23 22 22 21 22
LSMean 34 32 34 34 33 37
6 (Path B) Mean 28 32 29 23 29 26
S.D. 16.2 15.4 16.1 15.4 13.1 15.0
Page 332 of 4796
S.E. of Mean 3.4 3.2 3.4 3.3 2.9 3.1

N (Litters) 23 23 22 22 21 23
LSMean 28 32 29 23 29 26
7 (Path B) Mean 26 28 25 22 26 21
S.D. 15.4 15.4 16.9 17.6 16.9 14.9
S.E. of Mean 3.2 3.2 3.6 3.8 3.7 3.1
N (Litters) 23 23 22 22 21 23
LSMean 26 28 25 22 26 21
8 (Path B) Mean 16 25 26 15 19 15
S.D. 15.2 14.3 17.9 14.4 16.7 14.8
S.E. of Mean 3.2 3.0 3.8 3.1 3.6 3.1
N (Litters) 23 23 22 22 21 23
LSMean 16 26 26 15 19 15
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M 9 (Path B) Mean 16 22 24 8 17 18
% Difference Control 37.5 50.0 -50.0 6.3 12.5
S.D. 15.1 17.4 16.5 10.2 15.3 14.9
S.E. of Mean 3.2 3.6 3.5 2.2 3.3 3.1
N (Litters) 23 23 22 22 21 23
LSMean 16 22 24 8 17 19
10 (Path B) Mean 14 16 11 6 10 13
S.D. 14.8 15.7 11.1 6.6 10.6 14.4
Page 333 of 4796
S.E. of Mean 3.1 3.3 2.4 1.4 2.3 3.0

N (Litters) 23 23 22 22 21 23
LSMean 14 17 11 6 10 13
(Path B) Dunnett p-value# 0.511 0.871 0.361 1.000 0.999
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F 5 (Path B) Mean 39 31 34 32 32 27
S.D. 8.2 13.4 13.9 15.0 13.5 14.9
S.E. of Mean 1.7 2.8 2.9 3.2 2.9 3.1
N (Litters) 23 23 23 22 22 23
LSMean 39 31 34 32 32 27
6 (Path B) Mean 35 27 27 29 26 24
S.D. 12.7 14.9 14.4 14.0 15.2 14.2
Page 334 of 4796
S.E. of Mean 2.7 3.1 3.0 3.0 3.2 3.0

N (Litters) 23 23 23 22 22 23
LSMean 35 27 27 29 26 24
7 (Path B) Mean 31 20 29 27 21 20
S.D. 17.5 16.7 17.3 18.2 18.1 15.7
S.E. of Mean 3.7 3.5 3.6 3.9 3.9 3.3
N (Litters) 23 23 23 22 22 23
LSMean 31 20 28 27 21 20
8 (Path B) Mean 24 16 29 18 18 17
S.D. 13.4 15.0 16.4 14.6 16.7 13.8
S.E. of Mean 2.8 3.1 3.4 3.1 3.6 2.9
N (Litters) 23 23 23 22 22 23
LSMean 24 16 29 18 18 17
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F 9 (Path B) Mean 25 11 25 15 19 18
S.D. 17.4 11.6 17.4 15.5 16.9 17.7
S.E. of Mean 3.6 2.4 3.6 3.3 3.6 3.7
N (Litters) 23 23 23 22 22 23
LSMean 25 11 24 15 19 18
10 (Path B) Mean 13 9 20 13 14 14
S.D. 11.5 11.8 16.0 12.2 13.2 18.0
Page 335 of 4796
S.E. of Mean 2.4 2.5 3.3 2.6 2.8 3.8

N (Litters) 23 23 23 22 22 23
LSMean 13 9 20 13 14 14
(Path B) Dunnett p-value# 0.007* 1.000 0.167 0.096 0.025*
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P 11 (Path A) Mean 24 23 24 24 28 25
S.D. 10.4 9.3 12.9 12.0 12.0 11.1
S.E. of Mean 2.2 1.9 2.7 2.6 2.6 2.3
N (Litters) 23 23 23 22 22 23
LSMean 24 23 24 24 27 25
12 (Path A) Mean 18 16 14 14 18 14
S.D. 12.0 8.5 6.9 6.4 10.5 12.6
Page 336 of 4796
S.E. of Mean 2.5 1.8 1.4 1.4 2.2 2.6

N (Litters) 23 23 23 22 22 23
LSMean 18 16 14 14 18 14
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M 11 (Path A) Mean 24 18 20 21 27 27
% Difference Control -25.0 -16.7 -12.5 12.5 12.5
S.D. 14.8 12.7 15.5 15.3 13.4 16.8
S.E. of Mean 3.1 2.7 3.3 3.3 2.9 3.5
N (Litters) 23 23 22 22 21 23
12 (Path A) Mean 16 15 15 14 20 12
S.D. 14.0 11.0 11.4 13.4 12.3 11.6
S.E. of Mean 2.9 2.3 2.4 2.9 2.7 2.4
N (Litters) 23 23 22 22 21 23
Page 337 of 4796
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F 11 (Path A) Mean 23 29 28 26 27 23
S.D. 16.8 13.4 18.1 15.1 18.3 15.9
S.E. of Mean 3.5 2.8 3.8 3.2 3.9 3.3
N (Litters) 23 23 23 22 22 23
12 (Path A) Mean 20 17 13 13 17 16
S.D. 16.5 13.2 9.4 9.0 13.6 17.9
S.E. of Mean 3.4 2.8 2.0 1.9 2.9 3.7
N (Litters) 23 23 23 22 22 23
Page 338 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
TABLE 44 (F1 PND 62 - SUBSET A)

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P 1 (Path A) Mean 16 14 17 15 16 16
% Difference Control -12.5 6.3 -6.3 0.0 0.0
S.D. 9.1 10.2 10.4 9.7 11.2 10.1
S.E. of Mean 1.4 1.5 1.5 1.5 1.7 1.5
N 45 46 47 44 42 46
2 (Path A) Mean 10 13 10 12 12 11
S.D. 9.1 11.2 7.9 9.9 7.7 10.5
S.E. of Mean 1.4 1.6 1.2 1.5 1.2 1.5
N 45 46 47 44 43 46
Page 339 of 4796
3 (Path A) Mean 5 10 7 9 8 9
S.D. 5.9 8.6 8.4 10.0 10.7 7.4
S.E. of Mean 0.9 1.3 1.2 1.5 1.6 1.1
N 45 46 47 44 43 46
4 (Path A) Mean 4 6 4 4 5 4
S.D. 5.1 5.3 3.2 4.6 5.6 4.9
S.E. of Mean 0.8 0.8 0.5 0.7 0.8 0.7
N 45 46 47 44 43 46

(Path A) Treatment*Sex*Trial p-value# 0.044*
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M 1 (Path A) Mean 16 14 17 13 20 14
S.D. 8.1 10.8 8.4 10.5 12.8 8.5
S.E. of Mean 1.7 2.3 1.7 2.2 2.9 1.8
N 23 23 23 22 20 23
LSMean 15 15 17 13 20 14
2 (Path A) Mean 12 16 12 10 12 10
S.D. 9.5 12.7 9.6 9.1 8.6 8.4
S.E. of Mean 2.0 2.6 2.0 1.9 1.9 1.8
Page 340 of 4796
N 23 23 23 22 21 23
LSMean 12 16 12 10 12 10
3 (Path A) Mean 5 13 8 10 5 10
S.D. 6.2 9.3 8.9 11.0 5.7 7.4
S.E. of Mean 1.3 1.9 1.9 2.3 1.2 1.5
N 23 23 23 22 21 23
LSMean 5 13 8 10 5 10
4 (Path A) Mean 3 7 5 4 6 4
S.D. 3.5 5.1 4.0 5.1 7.0 5.5
S.E. of Mean 0.7 1.1 0.8 1.1 1.5 1.1
N 23 23 23 22 21 23
LSMean 3 7 5 4 6 4
(Path A) Dunnett p-value# 0.037* 0.811 1.000 0.466 0.989
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F 1 (Path A) Mean 16 13 17 17 12 19
S.D. 10.2 9.7 12.2 8.7 8.0 11.1
S.E. of Mean 2.2 2.0 2.5 1.9 1.7 2.3
N 22 23 24 22 22 23
LSMean 16 13 17 17 12 19
2 (Path A) Mean 9 10 8 13 11 12
% Difference Control 11.1 -11.1 44.4 22.2 33.3
S.D. 8.6 8.7 5.3 10.8 6.9 12.3
S.E. of Mean 1.8 1.8 1.1 2.3 1.5 2.6
Page 341 of 4796
N 22 23 24 22 22 23
LSMean 9 10 8 13 11 12
3 (Path A) Mean 5 8 6 7 11 8
S.D. 5.6 7.2 8.0 8.8 13.4 7.3
S.E. of Mean 1.2 1.5 1.6 1.9 2.9 1.5
N 22 23 24 22 22 23
LSMean 4 8 6 7 11 8
4 (Path A) Mean 5 5 3 4 4 4
S.D. 6.4 5.6 2.1 4.0 3.8 4.3
S.E. of Mean 1.4 1.2 0.4 0.9 0.8 0.9
N 22 23 24 22 22 23
LSMean 5 5 3 4 4 4
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P 5 (Path B) Mean 25 31 28 29 27 25
S.D. 12.4 14.5 12.2 12.1 13.5 11.8
S.E. of Mean 1.9 2.1 1.8 1.8 2.1 1.7
N 45 46 47 44 43 46
LSMean 25 31 28 29 27 25
Dunnett p-value# 0.112 0.688 0.392 0.782 0.998
6 (Path B) Mean 18 19 19 18 19 19
S.D. 14.0 14.3 13.6 12.8 13.0 13.1
S.E. of Mean 2.1 2.1 2.0 1.9 2.0 1.9
Page 342 of 4796
N 45 46 47 44 43 46
LSMean 18 19 19 18 19 19
Dunnett p-value# 0.997 1.000 1.000 1.000 1.000
7 (Path B) Mean 10 14 18 14 14 12
S.D. 12.2 12.9 14.5 13.1 12.7 12.3
S.E. of Mean 1.8 1.9 2.1 2.0 1.9 1.8
N 45 46 47 44 43 46
LSMean 10 14 18 14 14 12
Dunnett p-value# 0.611 0.026* 0.519 0.448 0.981
8 (Path B) Mean 11 12 9 8 11 7
S.D. 13.6 13.2 10.2 9.7 10.3 7.3
S.E. of Mean 2.0 1.9 1.5 1.5 1.6 1.1
N 45 46 47 44 42 46
LSMean 11 12 9 8 10 7
Dunnett p-value# 1.000 0.805 0.403 0.986 0.125
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P 9 (Path B) Mean 5 7 6 7 9 7
S.D. 7.8 9.8 7.9 9.2 8.9 7.0
S.E. of Mean 1.2 1.5 1.2 1.4 1.4 1.0
N 45 46 47 44 43 46
LSMean 5 7 7 7 9 7
Dunnett p-value# 0.439 0.738 0.661 0.110 0.677
10 (Path B) Mean 6 4 7 4 5 5
S.D. 9.5 6.2 8.9 5.2 8.4 7.8
Page 343 of 4796
S.E. of Mean 1.4 0.9 1.3 0.8 1.3 1.1

N 45 46 47 44 43 46
LSMean 6 4 7 4 5 5
Dunnett p-value# 0.512 0.982 0.467 0.968 0.791
(Path B) Dunnett p-value# NT NT NT NT NT
Treatment*Trial p-value# 0.043*
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M 5 (Path B) Mean 26 30 29 26 27 26
S.D. 12.6 12.9 9.6 9.8 11.8 10.0
S.E. of Mean 2.6 2.7 2.0 2.1 2.6 2.1
N 23 23 23 22 21 23
6 (Path B) Mean 17 19 20 20 17 17
S.D. 14.4 16.0 11.8 12.6 11.8 12.4
S.E. of Mean 3.0 3.3 2.5 2.7 2.6 2.6
N 23 23 23 22 21 23
Page 344 of 4796
7 (Path B) Mean 10 14 16 13 14 12
S.D. 12.0 13.2 14.7 12.3 12.9 13.0
S.E. of Mean 2.5 2.8 3.1 2.6 2.8 2.7
N 23 23 23 22 21 23
8 (Path B) Mean 8 12 11 11 11 8
S.D. 11.5 13.0 10.9 12.0 11.4 8.7
S.E. of Mean 2.4 2.7 2.3 2.6 2.5 1.8
N 23 23 23 22 21 23
9 (Path B) Mean 3 5 9 8 8 8
S.D. 7.5 7.3 9.1 11.1 8.5 8.3
S.E. of Mean 1.6 1.5 1.9 2.4 1.9 1.7
N 23 23 23 22 21 23
10 (Path B) Mean 6 4 7 4 5 6
% Difference Control -33.3 16.7 -33.3 -16.7 0.0
S.D. 8.4 6.9 6.9 5.4 8.0 10.3
S.E. of Mean 1.7 1.4 1.4 1.2 1.7 2.1
N 23 23 23 22 21 23
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F 5 (Path B) Mean 23 31 26 32 27 25
S.D. 12.4 16.2 14.3 13.5 15.2 13.5
S.E. of Mean 2.6 3.4 2.9 2.9 3.2 2.8
N 22 23 24 22 22 23
6 (Path B) Mean 20 20 18 17 21 21
% Difference Control 0.0 -10.0 -15.0 5.0 5.0
S.D. 13.7 12.7 15.4 13.0 14.0 13.8
S.E. of Mean 2.9 2.6 3.1 2.8 3.0 2.9
N 22 23 24 22 22 23
Page 345 of 4796
7 (Path B) Mean 10 14 19 15 14 11
S.D. 12.6 12.9 14.5 14.1 12.9 11.8
S.E. of Mean 2.7 2.7 3.0 3.0 2.8 2.5
N 22 23 24 22 22 23
8 (Path B) Mean 15 11 8 5 11 5
S.D. 15.0 13.6 9.5 5.3 9.3 5.6
S.E. of Mean 3.2 2.8 1.9 1.1 2.0 1.2
N 22 23 24 22 21 23
9 (Path B) Mean 6 9 4 5 9 5
S.D. 8.1 11.7 5.8 6.5 9.5 5.1
S.E. of Mean 1.7 2.4 1.2 1.4 2.0 1.1
N 22 23 24 22 22 23
10 (Path B) Mean 6 4 7 4 5 4
S.D. 10.8 5.6 10.6 5.0 9.0 4.0
S.E. of Mean 2.3 1.2 2.2 1.1 1.9 0.8
N 22 23 24 22 22 23
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
P 11 (Path A) Mean 15 16 18 18 14 17
S.D. 12.3 12.0 13.1 12.3 11.3 12.8
S.E. of Mean 1.8 1.8 1.9 1.8 1.7 1.9
N 45 46 47 44 43 46
LSMean 15 16 18 18 14 17
12 (Path A) Mean 8 7 7 8 8 7
S.D. 9.4 6.6 8.6 10.1 7.7 6.4
Page 346 of 4796
S.E. of Mean 1.4 1.0 1.3 1.5 1.2 0.9

N 45 46 47 44 43 46
LSMean 8 7 7 8 8 7
-------------------------------------------------------------------------------------------------------------------------------------
P = Sexes combined.

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
M 11 (Path A) Mean 16 14 16 17 14 20
S.D. 14.4 7.1 12.8 10.2 7.9 12.7
S.E. of Mean 3.0 1.5 2.7 2.2 1.7 2.6
N 23 23 23 22 21 23
12 (Path A) Mean 9 7 6 9 7 7
S.D. 10.8 7.1 6.9 10.9 7.3 6.6
S.E. of Mean 2.3 1.5 1.4 2.3 1.6 1.4
N 23 23 23 22 21 23
Page 347 of 4796
-------------------------------------------------------------------------------------------------------------------------------------

_________________________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
F 11 (Path A) Mean 14 19 20 19 13 15
S.D. 9.9 15.3 13.4 14.2 14.0 12.7
S.E. of Mean 2.1 3.2 2.7 3.0 3.0 2.6
N 22 23 24 22 22 23
12 (Path A) Mean 7 6 8 7 9 7
S.D. 7.8 6.3 9.9 9.5 8.1 6.5
S.E. of Mean 1.7 1.3 2.0 2.0 1.7 1.3
N 22 23 24 22 22 23
Page 348 of 4796
-------------------------------------------------------------------------------------------------------------------------------------
FINAL REPORT
Volume 2 of 16
(Summary Tables 45-56 and Appendix A [Table A1])
STUDY TITLE
STUDY NUMBER
WIL-186056
DATA REQUIREMENT

OECD Guideline 426
STUDY DIRECTOR
26 June 2008
30 September 2009

1407 George Road
SPONSOR

Arlington, VA 22209
Page 349 of 4796

TABLES 45 -56
Page 350 of 4796

TABLE 45 (F1 MALES - UNSCHEDULED DEATHS)

-----------------------------------------------------------------------------------------------------------------------------------
----- M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
SKIN

-----------------------------------------------------------------------------------------------------------------------------------
PGRSI2v4.07
03/27/2009
Page 351 of 4796
R:07/13/2009
TABLE 46 (F1 FEMALES - UNSCHEDULED DEATH)

-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
PGRSI2v4.07
03/27/2009
R:07/13/2009
Page 352 of 4796
TABLE 47 (F1 MALES - SCHEDULED NECROPSY - SUBSET B)
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
LUNGS
THYMUS

-----------------------------------------------------------------------------------------------------------------------------------
Page 353 of 4796
PGRSI2v4.07
03/26/2009
R:07/13/2009
TABLE 48 (F1 FEMALES - SCHEDULED NECROPSY - SUBSET B)
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
KIDNEYS
-CYST(S) 0 0 1 0 1 0
SPLEEN
-AREA(S), WHITE 0 0 0 1 0 0

-----------------------------------------------------------------------------------------------------------------------------------
Page 354 of 4796
PGRSI2v4.07
03/26/2009
R:07/13/2009
TABLE 49 (F1 - ANIMALS SELECTED FOR NEUROPATHOLOGY - PND 21 - SUBSET C)
PROJECT NO.:WIL-186056U DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
Page 355 of 4796
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
BRAIN

-----------------------------------------------------------------------------------------------------------------------------------
PGRSI2v4.07
Page 356 of 4796
08/17/2009
R:08/17/2009
TABLE 50 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 21 SUBSET C)
SPONSOR:ACC SUMMARY OF BRAIN WEIGHTS AND MEASUREMENTS

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
Period Sex Variable Statistic ________ ________ ________ ________ ________ ________ ___________
PND21 P Brain (GRAMS) Mean 1.6003 1.6481 1.5978 1.6095 1.5979 1.5880
S.D. 0.07569 0.10094 0.10753 0.08183 0.07596 0.06898
S.E. of Mean 0.01692 0.02257 0.02404 0.01830 0.01699 0.01542
N 20 20 20 20 20 20
LSMean 1.6003 1.6447 1.6012 1.6061 1.5945 1.5813
Dunnett p-value# 0.148 1.000 0.999 0.999 0.842
Brain Length (MM) Mean 18.1 18.2 18.1 18.1 18.1 18.0
S.D. 0.27 0.38 0.45 0.45 0.32 0.37
Page 357 of 4796
S.E. of Mean 0.06 0.08 0.10 0.10 0.07 0.08

N 20 20 20 20 20 20
LSMean 18.1 18.2 18.1 18.1 18.1 18.0
Dunnett p-value# 0.985 0.977 0.932 1.000 0.523
Brain Width (MM) Mean 14.6 14.7 14.5 14.6 14.5 14.6
S.D. 0.31 0.39 0.44 0.25 0.20 0.29
S.E. of Mean 0.07 0.09 0.10 0.06 0.05 0.07
N 20 20 20 20 20 20
LSMean 14.6 14.7 14.5 14.6 14.5 14.6
Dunnett p-value# 0.348 0.985 1.000 0.842 0.999
MANOVA
Wilks' Lambda Trt p-value# 0.422
Wilks' Lambda Trt*Sex p-value# 0.301
-------------------------------------------------------------------------------------------------------------------------------------

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND21 M Brain (GRAMS) Mean 1.6379 1.6909 1.6619 1.6461 1.6428 1.6191
S.D. 0.08954 0.11710 0.08955 0.08289 0.05422 0.04342
S.E. of Mean 0.02831 0.03703 0.02832 0.02621 0.01714 0.01373
N 10 10 10 10 10 10
S.D. 0.26 0.34 0.37 0.45 0.18 0.37
S.E. of Mean 0.08 0.11 0.12 0.14 0.06 0.12
N 10 10 10 10 10 10
Page 358 of 4796
S.D. 0.28 0.31 0.37 0.29 0.23 0.15
S.E. of Mean 0.09 0.10 0.12 0.09 0.07 0.05
N 10 10 10 10 10 10
-------------------------------------------------------------------------------------------------------------------------------------
Not statistically analyzed.

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND21 F Brain (GRAMS) Mean 1.5627 1.6053 1.5338 1.5729 1.5529 1.5570
S.D. 0.03062 0.06100 0.08526 0.06548 0.06898 0.07755
S.E. of Mean 0.00968 0.01929 0.02696 0.02071 0.02181 0.02452
N 10 10 10 10 10 10
S.D. 0.20 0.41 0.46 0.37 0.33 0.34
S.E. of Mean 0.06 0.13 0.14 0.12 0.10 0.11
N 10 10 10 10 10 10
Page 359 of 4796
S.D. 0.31 0.35 0.37 0.20 0.18 0.29
S.E. of Mean 0.10 0.11 0.12 0.06 0.06 0.09
N 10 10 10 10 10 10
-------------------------------------------------------------------------------------------------------------------------------------
----- MALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
BASAL GANGLIA
-EMBRYONAL CELL NEST 0 3 0 0 0 1
MINIMAL NONE 2 NONE NONE NONE 1
MILD NONE 1 NONE NONE NONE NONE
CEREBELLUM
Page 360 of 4796
CEREBRAL CORTEX
HIPPOCAMPUS
HYPOTHALAMUS
-----------------------------------------------------------------------------------------------------------------------------------
----- MALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
MEDULLA OBLONG.
MIDBRAIN
OLFACTORY BULBS
Page 361 of 4796
PONS
THALAMUS
-----------------------------------------------------------------------------------------------------------------------------------
----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
BASAL GANGLIA
-EMBRYONAL CELL NEST 0 1 0 1 0 0
MINIMAL NONE 1 NONE 1 NONE NONE
CEREBELLUM
Page 362 of 4796
CEREBRAL CORTEX
-CORTICAL DYSPLASIA 0 0 0 0 1 0
MILD NONE NONE NONE NONE 1 NONE
HIPPOCAMPUS
HYPOTHALAMUS
-----------------------------------------------------------------------------------------------------------------------------------
----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
MEDULLA OBLONG.
MIDBRAIN
OLFACTORY BULBS
Page 363 of 4796
PONS
THALAMUS
-----------------------------------------------------------------------------------------------------------------------------------
PHSI2v4.30
08/17/2009
R:08/17/2009
SPONSOR:ACC SUMMARY OF BRAIN MORPHOMETRY [CM]

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND21 P Level 1 - HT Mean 0.7177 0.7271 0.7159 0.7195 0.7157 0.7153

Hemisphere
S.D. 0.02391 0.02911 0.02753 0.02726 0.02484 0.02100
S.E. of Mean 0.00535 0.00651 0.00616 0.00610 0.00570 0.00470
N 20 20 20 20 19 20
LSMean 0.7177 0.7259 0.7171 0.7183 0.7150 0.7129
Dunnett p-value# 0.689 1.000 1.000 0.995 0.948
Level 1 - V Mean 0.1792 0.1782 0.1780 0.1748 0.1774 0.1755

Thickness Cortex
Page 364 of 4796
S.D. 0.00872 0.01141 0.01250 0.01054 0.01039 0.00788

S.E. of Mean 0.00200 0.00255 0.00280 0.00236 0.00238 0.00176
N 19 20 20 20 19 20
LSMean 0.1793 0.1777 0.1785 0.1743 0.1771 0.1745
Dunnett p-value# 0.975 0.999 0.302 0.918 0.340
Level 3 - Radial Mean 0.1584 0.1578 0.1560 0.1543 0.1537 0.1548

Thickness Cortex
S.D. 0.00828 0.00897 0.00844 0.00847 0.01124 0.00784
S.E. of Mean 0.00185 0.00201 0.00189 0.00189 0.00251 0.00175
N 20 20 20 20 20 20
LSMean 0.1584 0.1575 0.1563 0.1540 0.1534 0.1541
Dunnett p-value# 0.997 0.898 0.325 0.226 0.366
-------------------------------------------------------------------------------------------------------------------------------------

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND21 P Level 3 - V HT Btw Mean 0.0910 0.0901 0.0892 0.0889 0.0909 0.0906
Hippo Pyramidal
Neuron Layers
S.D. 0.00617 0.00406 0.00430 0.00608 0.00571 0.00559
S.E. of Mean 0.00138 0.00091 0.00096 0.00136 0.00128 0.00125
N 20 20 20 20 20 20
LSMean 0.0910 0.0899 0.0893 0.0887 0.0907 0.0902
Dunnett p-value# 0.942 0.764 0.467 1.000 0.985
Level 3 - V HT Mean 0.0495 0.0489 0.0488 0.0484 0.0493 0.0485

Page 365 of 4796
Dentate Hilus
S.D. 0.00409 0.00387 0.00389 0.00396 0.00351 0.00377
S.E. of Mean 0.00092 0.00087 0.00087 0.00089 0.00078 0.00084
N 20 20 20 20 20 20
LSMean 0.0495 0.0488 0.0489 0.0482 0.0491 0.0482
Dunnett p-value# 0.966 0.986 0.742 0.999 0.742
Level 3 - Length Mean 0.1421 0.1397 0.1368 0.1380 0.1372 0.1413

Ventral Limb
Dentate Hilus
S.D. 0.01399 0.01353 0.01924 0.01774 0.01164 0.01291
S.E. of Mean 0.00321 0.00310 0.00430 0.00397 0.00260 0.00289
N 19 19 20 20 20 20
LSMean 0.1423 0.1396 0.1372 0.1376 0.1368 0.1405
Dunnett p-value# 0.964 0.665 0.741 0.603 0.993
-------------------------------------------------------------------------------------------------------------------------------------

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND21 P Level 5 - V Height Mean 0.4774 0.4748 0.4706 0.4784 0.4710 0.4683
of the Cerebellum
S.D. 0.01600 0.02931 0.03502 0.03097 0.02815 0.02729
S.E. of Mean 0.00358 0.00655 0.00803 0.00693 0.00629 0.00626
N 20 20 19 20 20 19
LSMean 0.4774 0.4736 0.4722 0.4772 0.4698 0.4650
Dunnett p-value# 0.988 0.956 1.000 0.816 0.426
Level 5 - Base of Mean 0.0649 0.0645 0.0643 0.0637 0.0637 0.0633

Lobule 9
Page 366 of 4796
S.D. 0.00438 0.00557 0.00557 0.00550 0.00393 0.00528

S.E. of Mean 0.00098 0.00125 0.00128 0.00123 0.00088 0.00118
N 20 20 19 20 20 20
LSMean 0.0649 0.0644 0.0643 0.0637 0.0637 0.0633
Dunnett p-value# 0.999 0.997 0.916 0.919 0.770
-------------------------------------------------------------------------------------------------------------------------------------

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND21 M Level 1 - HT Mean 0.7184 0.7286 0.7251 0.7209 0.7165 0.7093

Hemisphere
S.D. 0.03063 0.03683 0.02862 0.02567 0.02167 0.01499
S.E. of Mean 0.00969 0.01165 0.00905 0.00812 0.00685 0.00474
N 10 10 10 10 10 10
Level 1 - V Mean 0.1773 0.1810 0.1813 0.1777 0.1790 0.1764

Thickness Cortex
S.D. 0.01127 0.01066 0.01589 0.01088 0.00633 0.00843
S.E. of Mean 0.00376 0.00337 0.00502 0.00344 0.00200 0.00267
N 9 10 10 10 10 10
Page 367 of 4796

Thickness Cortex
S.D. 0.00829 0.00999 0.00708 0.01026 0.00998 0.01012
S.E. of Mean 0.00262 0.00316 0.00224 0.00325 0.00315 0.00320
N 10 10 10 10 10 10
-------------------------------------------------------------------------------------------------------------------------------------

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND21 M Level 3 - V HT Btw Mean 0.0904 0.0905 0.0900 0.0904 0.0904 0.0919
Hippo Pyramidal
Neuron Layers
S.D. 0.00730 0.00386 0.00516 0.00661 0.00512 0.00498
S.E. of Mean 0.00231 0.00122 0.00163 0.00209 0.00162 0.00157
N 10 10 10 10 10 10
Level 3 - V HT Mean 0.0490 0.0495 0.0497 0.0485 0.0496 0.0488

Dentate Hilus
S.D. 0.00535 0.00424 0.00459 0.00394 0.00252 0.00363
S.E. of Mean 0.00169 0.00134 0.00145 0.00125 0.00080 0.00115
Page 368 of 4796
N 10 10 10 10 10 10

Ventral Limb
Dentate Hilus
S.D. 0.01660 0.01407 0.00726 0.01589 0.01138 0.01309
S.E. of Mean 0.00553 0.00469 0.00230 0.00502 0.00360 0.00414
N 9 9 10 10 10 10
Level 5 - V Height Mean 0.4794 0.4778 0.4789 0.4870 0.4775 0.4700

of the Cerebellum
S.D. 0.02028 0.03022 0.03695 0.03142 0.02137 0.02600
S.E. of Mean 0.00641 0.00956 0.01168 0.00994 0.00676 0.00822
N 10 10 10 10 10 10

Lobule 9
S.D. 0.00397 0.00761 0.00534 0.00706 0.00447 0.00401
S.E. of Mean 0.00125 0.00241 0.00169 0.00223 0.00141 0.00127
N 10 10 10 10 10 10
-------------------------------------------------------------------------------------------------------------------------------------

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND21 F Level 1 - HT Mean 0.7171 0.7256 0.7067 0.7181 0.7147 0.7214

Hemisphere
S.D. 0.01637 0.02068 0.02435 0.03009 0.02930 0.02499
S.E. of Mean 0.00518 0.00654 0.00770 0.00952 0.00977 0.00790
N 10 10 10 10 9 10
Level 1 - V Mean 0.1809 0.1753 0.1747 0.1719 0.1757 0.1745

Thickness Cortex
S.D. 0.00569 0.01198 0.00726 0.00989 0.01382 0.00763
S.E. of Mean 0.00180 0.00379 0.00229 0.00313 0.00461 0.00241
N 10 10 10 10 9 10
Page 369 of 4796

Thickness Cortex
S.D. 0.00705 0.00831 0.00987 0.00676 0.01290 0.00513
S.E. of Mean 0.00223 0.00263 0.00312 0.00214 0.00408 0.00162
N 10 10 10 10 10 10
------------------------------------------------------------------------------------------------------------------------------------

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND21 F Level 3 - V HT Btw Mean 0.0915 0.0897 0.0883 0.0873 0.0915 0.0892
Hippo Pyramidal
Neuron Layers
S.D. 0.00515 0.00442 0.00332 0.00539 0.00647 0.00610
S.E. of Mean 0.00163 0.00140 0.00105 0.00170 0.00205 0.00193
N 10 10 10 10 10 10
Level 3 - V HT Mean 0.0499 0.0484 0.0479 0.0482 0.0489 0.0483

Dentate Hilus
S.D. 0.00249 0.00360 0.00301 0.00419 0.00440 0.00408
S.E. of Mean 0.00079 0.00114 0.00095 0.00132 0.00139 0.00129
Page 370 of 4796
N 10 10 10 10 10 10

Ventral Limb
Dentate Hilus
S.D. 0.01199 0.01340 0.02236 0.01917 0.00687 0.01223
S.E. of Mean 0.00379 0.00424 0.00707 0.00606 0.00217 0.00387
N 10 10 10 10 10 10

of the Cerebellum
S.D. 0.01100 0.02968 0.03225 0.02955 0.03349 0.03013
S.E. of Mean 0.00348 0.00939 0.01075 0.00934 0.01059 0.01004
N 10 10 9 10 10 9

Lobule 9
S.D. 0.00381 0.00273 0.00608 0.00374 0.00317 0.00647
S.E. of Mean 0.00120 0.00086 0.00203 0.00118 0.00100 0.00205
N 10 10 9 10 10 10
-------------------------------------------------------------------------------------------------------------------------------------
TABLE 53 (F1 - ANIMALS SELECTED FOR NEUROPATHOLOGY - PND 72 - SUBSET A)
PROJECT NO.:WIL-186056V DIETARY DEVELOPMENTAL NEUROTOXICITY STUDY OF BISPHENOL A IN RATS PAGE 1
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
BRAIN

-----------------------------------------------------------------------------------------------------------------------------------
Page 371 of 4796
SCHEDULED NECROPSY
-----------------------------------------------------------------------------------------------------------------------------------
----- F E M A L E -----
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
PGRSI2v4.07
08/17/2009
R:09/18/2009
Page 372 of 4796
TABLE 54 (F1 ANIMALS SELECTED FOR NEUROPATHOLOGY PND 72 SUBSET A)

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND72 P Brain (GRAMS) Mean 2.1015 2.1665 2.1170 2.0830 2.0660 2.0650
S.D. 0.11310 0.12175 0.10048 0.12974 0.13040 0.13225
S.E. of Mean 0.02529 0.02722 0.02247 0.02901 0.02916 0.02957
N 20 20 20 20 20 20
LSMean 2.1052 2.1665 2.1170 2.0812 2.0642 2.0632
Pairwise p-value# 0.029 0.670 0.389 0.142 0.133
S.D. 0.47 0.50 0.52 0.44 0.38 0.46
S.E. of Mean 0.11 0.11 0.12 0.10 0.09 0.10
Page 373 of 4796
N 20 20 20 20 20 20
LSMean 20.7 20.7 20.8 20.6 20.7 20.6
Pairwise p-value# 0.965 0.428 0.121 0.417 0.283
S.D. 0.36 0.41 0.35 0.39 0.38 0.42
S.E. of Mean 0.08 0.09 0.08 0.09 0.09 0.09
N 20 20 20 20 20 20
LSMean 15.4 15.5 15.4 15.3 15.2 15.3
Pairwise p-value# 0.295 0.833 0.230 0.024 0.331
MANOVA
Wilks' Lambda Trt p-value# 0.015*
-------------------------------------------------------------------------------------------------------------------------------------
listed under individual dose group (pairwise comparison with control) are tested at 0.02 level.

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND72 M Brain (GRAMS) Mean 2.1820 2.2530 2.1720 2.1840 2.1520 2.1500
S.D. 0.08270 0.08274 0.10163 0.08140 0.09473 0.11324
S.E. of Mean 0.02615 0.02616 0.03214 0.02574 0.02996 0.03581
N 10 10 10 10 10 10
S.D. 0.45 0.47 0.36 0.24 0.28 0.37
S.E. of Mean 0.14 0.15 0.11 0.08 0.09 0.12
N 10 10 10 10 10 10
Page 374 of 4796
S.D. 0.24 0.25 0.32 0.25 0.25 0.39
S.E. of Mean 0.07 0.08 0.10 0.08 0.08 0.12
N 10 10 10 10 10 10
-------------------------------------------------------------------------------------------------------------------------------------

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND72 F Brain (GRAMS) Mean 2.0210 2.0800 2.0620 1.9820 1.9800 1.9800
S.D. 0.07593 0.08844 0.06529 0.07899 0.10242 0.08969
S.E. of Mean 0.02401 0.02797 0.02065 0.02498 0.03239 0.02836
N 10 10 10 10 10 10
S.D. 0.29 0.36 0.34 0.32 0.34 0.40
S.E. of Mean 0.09 0.11 0.11 0.10 0.11 0.13
Page 375 of 4796
N 10 10 10 10 10 10
S.D. 0.28 0.38 0.18 0.17 0.32 0.25
S.E. of Mean 0.09 0.12 0.06 0.05 0.10 0.08
N 10 10 10 10 10 10
-------------------------------------------------------------------------------------------------------------------------------------
----- MALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
BASAL GANGLIA
BRAIN
TOTAL NUMBER EXAMINED NA NA 2 NA NA NA
EXAMINED, UNREMARKABLE NA NA 0 NA NA NA
-HYDROCEPHALUS NA NA 2 NA NA NA
MINIMAL NA NA 2 NA NA NA
Page 376 of 4796
CEREBELLUM
CEREBRAL CORTEX
CERV SPIN NERVE - A

TOTAL NUMBER EXAMINED NA 1 NA NA NA NA
EXAMINED, UNREMARKABLE NA 0 NA NA NA NA
-DEGENERATION, AXONAL NA 1 NA NA NA NA
MINIMAL NA 1 NA NA NA NA
-----------------------------------------------------------------------------------------------------------------------------------
NA = NOT APPLICABLE
A = THE CERVICAL AND LUMBAR SPINAL NERVES WERE EXAMINED FOR ALL ANIMALS. HOWEVER, FINDINGS WERE TABULATED ONLY IF THERE WAS
AN ABNORMALITY PRESENT.
----- MALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
CERV. DOR. FIB.

CERV. DOR. GANG.

CERV. VENT. FIB.

Page 377 of 4796
NOT PRESENT FOR EXAMINATION 0 1 0 0 0 0

-DEGENERATION, AXONAL 0 0 0 1 0 0
MINIMAL NONE NONE NONE 1 NONE NONE
EYES
-DYSPLASIA, RETINAL 0 0 0 0 0 1
MINIMAL NONE NONE NONE NONE NONE 1
-KERATITIS 1 0 0 0 0 0
-MINERALIZATION, CORNEAL 1 0 0 0 0 0
MILD 1 NONE NONE NONE NONE NONE
-----------------------------------------------------------------------------------------------------------------------------------
----- MALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
GASTROC. MUSCLE
-DEGENERATION, MUSCLE 0 2 2 2 2 1
MINIMAL NONE 2 2 2 2 1
MINIMAL NONE NONE 1 1 1 NONE
HIPPOCAMPUS
Page 378 of 4796
HYPOTHALAMUS
LUM SPIN NERVE - A

EXAMINED, UNREMARKABLE 1-B 0 0 0 0 0
MINIMAL NA 3 4 2 1 1
-----------------------------------------------------------------------------------------------------------------------------------
NA = NOT APPLICABLE
B = DUE TO A TECHNICAL ERROR, THE LUMBAR SPINAL NERVE WAS RECORDED AS BEING EXAMINED FOR MALE NO. 26452-02 DESPITE HAVING
NO ABNORMALITIES PRESENT.
----- MALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
LUMBAR DOR. FIB.

MINIMAL 2 3 4 2 5 2
LUMBAR DOR. GANG

LUMBAR VENT. FIB

Page 379 of 4796

MINIMAL NONE 2 1 2 NONE 2
MEDULLA OBLONG.
MIDBRAIN
-----------------------------------------------------------------------------------------------------------------------------------
----- MALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
OLFACTORY BULBS
OPTIC NERVE
PERONEAL NERVE
Page 380 of 4796
PONS
SCIATIC NERVE
MINIMAL 6 7 6 8 7 6
-----------------------------------------------------------------------------------------------------------------------------------
----- MALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
SCIATIC NERVE - CONTINUED
SPINAL C.-CERV.
MINIMAL 1 1 NONE NONE NONE NONE
SPINAL C.-LUMB.
Page 381 of 4796
MINIMAL NONE NONE 1 NONE NONE 1
SURAL NERVE
THALAMUS
-----------------------------------------------------------------------------------------------------------------------------------
----- MALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
TIBIAL NERVE
TRIG. GANGLION
Page 382 of 4796
TRIGEMINAL NERVE
MINIMAL 1 NONE NONE 1 NONE 1
-----------------------------------------------------------------------------------------------------------------------------------
----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
BASAL GANGLIA
CEREBELLUM
CEREBRAL CORTEX
Page 383 of 4796
CERV SPIN NERVE - A

TOTAL NUMBER EXAMINED NA NA NA NA NA NA
EXAMINED, UNREMARKABLE NA NA NA NA NA NA
CERV. DOR. FIB.

CERV. DOR. GANG.

CERV. VENT. FIB.

-----------------------------------------------------------------------------------------------------------------------------------
NA = NOT APPLICABLE
----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
EYES
-DYSPLASIA, RETINAL 0 0 1 0 1 0
MINIMAL NONE NONE 1 NONE 1 NONE
GASTROC. MUSCLE
-DEGENERATION, MUSCLE 0 1 1 0 1 1
Page 384 of 4796
MINIMAL NONE 1 1 NONE 1 1

HIPPOCAMPUS
HYPOTHALAMUS
-----------------------------------------------------------------------------------------------------------------------------------
----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
LUM SPIN NERVE - A

TOTAL NUMBER EXAMINED 1 1 1 1 NA NA
EXAMINED, UNREMARKABLE 0 0 0 0 NA NA
-DEGENERATION, AXONAL 1 1 1 1 NA NA
MINIMAL 1 1 1 1 NA NA
LUMBAR DOR. FIB.

MINIMAL 1 1 2 1 NONE NONE
Page 385 of 4796
LUMBAR DOR. GANG

LUMBAR VENT. FIB

MINIMAL NONE NONE 1 3 2 2
-----------------------------------------------------------------------------------------------------------------------------------
NA = NOT APPLICABLE
----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
MEDULLA OBLONG.
MIDBRAIN
OLFACTORY BULBS
Page 386 of 4796
OPTIC NERVE
PERONEAL NERVE
MINIMAL 1 2 1 1 4 2
-----------------------------------------------------------------------------------------------------------------------------------
----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
PONS
SCIATIC NERVE
MINIMAL 6 4 7 3 4 7
-ECTOPIC TISSUE 0 1 0 1 0 0
Page 387 of 4796
MINIMAL NONE 1 NONE 1 NONE NONE
SPINAL C.-CERV.
SPINAL C.-LUMB.
-CYST, KERATIN 0 0 1 0 0 0
MILD NONE NONE 1 NONE NONE NONE
-----------------------------------------------------------------------------------------------------------------------------------
----- FEMALE -----

-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
SURAL NERVE
MINIMAL 1 1 1 NONE NONE NONE
THALAMUS
TIBIAL NERVE
Page 388 of 4796

MINIMAL 1 NONE NONE 2 NONE 1
TRIG. GANGLION
TRIGEMINAL NERVE
-----------------------------------------------------------------------------------------------------------------------------------
PHSI2v4.30
08/17/2009
R:09/09/2009

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND72 P Level 1 - HT Mean 0.7253 0.7310 0.7198 0.7276 0.7108 0.7154

Hemisphere
S.D. 0.02565 0.03139 0.02923 0.02910 0.03367 0.03340
S.E. of Mean 0.00574 0.00702 0.00654 0.00651 0.00753 0.00747
N 20 20 20 20 20 20
LSMean 0.7284 0.7324 0.7180 0.7309 0.7110 0.7116
Level 1 - V Mean 0.1770 0.1801 0.1798 0.1776 0.1746 0.1773

Thickness Cortex
S.D. 0.00716 0.01056 0.00718 0.00682 0.00855 0.00886
S.E. of Mean 0.00160 0.00236 0.00161 0.00153 0.00191 0.00198
Page 389 of 4796
N 20 20 20 20 20 20
LSMean 0.1770 0.1809 0.1793 0.1771 0.1747 0.1773

Thickness Cortex
S.D. 0.01249 0.01010 0.00935 0.00989 0.00866 0.00887
S.E. of Mean 0.00279 0.00226 0.00209 0.00221 0.00194 0.00198
N 20 20 20 20 20 20
LSMean 0.1691 0.1727 0.1644 0.1711 0.1673 0.1642
-------------------------------------------------------------------------------------------------------------------------------------

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND72 P Level 3 - V HT Btw Mean 0.0947 0.0971 0.0954 0.0954 0.0920 0.0918
Hippo Pyramidal
Neuron Layers
S.D. 0.00470 0.00531 0.00755 0.00930 0.00786 0.00742
S.E. of Mean 0.00105 0.00119 0.00169 0.00208 0.00176 0.00166
N 20 20 20 20 20 20
LSMean 0.0959 0.0976 0.0966 0.0969 0.0924 0.0923
Level 3 - V HT Mean 0.0499 0.0505 0.0513 0.0514 0.0498 0.0496

Dentate Hilus
S.D. 0.00288 0.00410 0.00289 0.00423 0.00305 0.00378
Page 390 of 4796
S.E. of Mean 0.00068 0.00094 0.00068 0.00097 0.00070 0.00087

N 18 19 18 19 19 19
LSMean 0.0499 0.0506 0.0512 0.0514 0.0498 0.0496

Ventral Limb
Dentate Hilus
S.D. 0.01276 0.01231 0.01540 0.01681 0.01816 0.01417
S.E. of Mean 0.00285 0.00275 0.00344 0.00376 0.00406 0.00317
N 20 20 20 20 20 20
LSMean 0.1469 0.1459 0.1424 0.1435 0.1374 0.1406
-------------------------------------------------------------------------------------------------------------------------------------

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND72 P Level 5 - V Height Mean 0.5141 0.5174 0.5088 0.5105 0.4990 0.4928
of the Cerebellum
S.D. 0.02751 0.03020 0.02004 0.02488 0.02480 0.02552
S.E. of Mean 0.00631 0.00675 0.00448 0.00556 0.00555 0.00571
N 19 20 20 20 20 20
LSMean 0.5136 0.5184 0.5083 0.5120 0.5000 0.4914

Lobule 9
S.D. 0.00558 0.00670 0.00510 0.00552 0.00490 0.00455
S.E. of Mean 0.00128 0.00150 0.00114 0.00123 0.00110 0.00102
Page 391 of 4796
N 19 20 20 20 20 20
LSMean 0.0739 0.0738 0.0720 0.0729 0.0747 0.0745
MANOVA
Wilks' Lambda Trt p-value# 0.071
-------------------------------------------------------------------------------------------------------------------------------------

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND72 M Level 1 - HT Mean 0.7304 0.7335 0.7067 0.7277 0.7190 0.7124

Hemisphere
S.D. 0.03043 0.03718 0.03047 0.03276 0.03626 0.03287
S.E. of Mean 0.00962 0.01176 0.00964 0.01036 0.01147 0.01040
N 10 10 10 10 10 10
Level 1 - V Mean 0.1776 0.1814 0.1800 0.1788 0.1766 0.1794

Thickness Cortex
S.D. 0.00929 0.01309 0.00744 0.00599 0.01048 0.00818
S.E. of Mean 0.00294 0.00414 0.00235 0.00190 0.00332 0.00259
N 10 10 10 10 10 10
Page 392 of 4796

Thickness Cortex
S.D. 0.01417 0.01122 0.00895 0.00774 0.00751 0.00936
S.E. of Mean 0.00448 0.00355 0.00283 0.00245 0.00237 0.00296
N 10 10 10 10 10 10
-------------------------------------------------------------------------------------------------------------------------------------

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND72 M Level 3 - V HT Btw Mean 0.0966 0.0972 0.0967 0.0982 0.0935 0.0951
Hippo Pyramidal
Neuron Layers
S.D. 0.00412 0.00505 0.00854 0.01058 0.00867 0.00744
S.E. of Mean 0.00130 0.00160 0.00270 0.00335 0.00274 0.00235
N 10 10 10 10 10 10
Level 3 - V HT Mean 0.0496 0.0499 0.0503 0.0520 0.0494 0.0509

Dentate Hilus
S.D. 0.00341 0.00473 0.00256 0.00361 0.00316 0.00346
S.E. of Mean 0.00114 0.00149 0.00085 0.00120 0.00100 0.00115
Page 393 of 4796
N 9 10 9 9 10 9

Ventral Limb
Dentate Hilus
S.D. 0.01224 0.01433 0.01136 0.01423 0.02412 0.01595
S.E. of Mean 0.00387 0.00453 0.00359 0.00450 0.00763 0.00504
N 10 10 10 10 10 10

of the Cerebellum
S.D. 0.03035 0.02422 0.02259 0.03039 0.02833 0.02265
S.E. of Mean 0.00960 0.00766 0.00714 0.00961 0.00896 0.00716
N 10 10 10 10 10 10

Lobule 9
S.D. 0.00616 0.00841 0.00521 0.00573 0.00587 0.00349
S.E. of Mean 0.00195 0.00266 0.00165 0.00181 0.00186 0.00110
N 10 10 10 10 10 10
-------------------------------------------------------------------------------------------------------------------------------------

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND72 F Level 1 - HT Mean 0.7202 0.7285 0.7329 0.7275 0.7025 0.7184

Hemisphere
S.D. 0.02015 0.02615 0.02226 0.02674 0.03045 0.03541
S.E. of Mean 0.00637 0.00827 0.00704 0.00846 0.00963 0.01120
N 10 10 10 10 10 10
Level 1 - V Mean 0.1764 0.1787 0.1795 0.1764 0.1725 0.1752

Thickness Cortex
S.D. 0.00460 0.00776 0.00731 0.00770 0.00592 0.00942
S.E. of Mean 0.00146 0.00245 0.00231 0.00243 0.00187 0.00298
N 10 10 10 10 10 10
Page 394 of 4796

Thickness Cortex
S.D. 0.01085 0.00845 0.00993 0.01181 0.01010 0.00883
S.E. of Mean 0.00343 0.00267 0.00314 0.00374 0.00319 0.00279
N 10 10 10 10 10 10
------------------------------------------------------------------------------------------------------------------------------------

_____________________________________________________ Statistical
0 0.15 1.5 75 750 2250 Model
PND72 F Level 3 - V HT Btw Mean 0.0929 0.0971 0.0940 0.0926 0.0904 0.0885
Hippo Pyramidal
Neuron Layers
S.D. 0.00466 0.00583 0.00658 0.00728 0.00707 0.00606
S.E. of Mean 0.00148 0.00184 0.00208 0.00230 0.00224 0.00192
N 10 10 10 10 10 10
Level 3 - V HT Mean 0.0502 0.0512 0.0523 0.0507 0.0503 0.0484

Dentate Hilus
S.D. 0.00242 0.00340 0.00298 0.00483 0.00303 0.00383
S.E. of Mean 0.00081 0.00113 0.00099 0.00153 0.00101 0.00121
Page 395 of 4796
N 9 9 9 10 9 10

Ventral Limb
Dentate Hilus
S.D. 0.01254 0.00991 0.01906 0.01982 0.01020 0.00871
S.E. of Mean 0.00396 0.00313 0.00603 0.00627 0.00323 0.00275
N 10 10 10 10 10 10
Level 5 V Height Mean 0.5014 0.5061 0.5070 0.5025 0.4871 0.4796

of the Cerebellum
S.D. 0.01788 0.03245 0.01819 0.01556 0.01353 0.02181
S.E. of Mean 0.00596 0.01026 0.00575 0.00492 0.00428 0.00690
N 9 10 10 10 10 10

Lobule 9
S.D. 0.00449 0.00489 0.00519 0.00551 0.00385 0.00500
S.E. of Mean 0.00150 0.00155 0.00164 0.00174 0.00122 0.00158
N 9 10 10 10 10 10
-------------------------------------------------------------------------------------------------------------------------------------
APPENDIX A
Individual Animal Data
TABLE A1
Page 396 of 4796

TABLE A1 (F0 - DAILY EXAMINATIONS)
SPONSOR:ACC INDIVIDUAL CLINICAL OBSERVATIONS
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS
-----------------------------------------------------------------------------------------------------------------------------------
23243 F 0 PPM NORMAL 07-14-08 9:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS
07-15-08 11:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS
Page 397 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 398 of 4796

23243 F 0 PPM DISPOSITION 08-25-08 10:26 P SCHEDULED EUTHANASIA; LACTATION DAY 21
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 399 of 4796

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23203 F 0 PPM BODY/INTEGUMENT 08-13-08 13:40 1 HAIR LOSS RIGHT FORELIMB
08-13-08 13:40 1 HAIR LOSS LEFT FORELIMB
08-14-08 13:01 1 HAIR LOSS RIGHT FORELIMB
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23203 F 0 PPM BODY/INTEGUMENT 08-27-08 10:19 1 HAIR LOSS LEFT FORELIMB
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26452 F 0 PPM EYES/EARS/NOSE 08-19-08 8:45 1 DRIED RED MATERIAL AROUND NOSE
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26528 F 0 PPM DISPOSITION 09-07-08 11:16 P SCHEDULED EUTHANASIA; POST-MATING DAY 25
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08-29-08 6:41 1 HAIR LOSS VENTRAL THORACIC AREA
08-29-08 6:42 1 HAIR LOSS VENTRAL ABDOMINAL AREA
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23195 F 0.15 PPM NORMAL 07-14-08 9:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS
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23195 F 0.15 PPM DISPOSITION 08-26-08 10:35 P SCHEDULED EUTHANASIA; LACTATION DAY 21
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23180 F 0.15 PPM BODY/INTEGUMENT 08-01-08 7:33 1 HAIR LOSS RIGHT FORELIMB
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23180 F 0.15 PPM BODY/INTEGUMENT 08-16-08 12:31 1 HAIR LOSS LEFT FORELIMB
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23180 F 0.15 PPM EYES/EARS/NOSE 07-27-08 6:34 1 DRIED RED MATERIAL AROUND NOSE
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23199 F 0.15 PPM DISPOSITION 08-10-08 9:47 P SCHEDULED EUTHANASIA; POST-MATING DAY 25
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23205 F 0.15 PPM EYES/EARS/NOSE 08-11-08 10:33 1 DRIED RED MATERIAL AROUND RIGHT EYE
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09-05-08 9:22 P SCABBING RIGHT FORELIMB
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26514 F 1.5 PPM BODY/INTEGUMENT 08-18-08 7:35 P SCABBING VENTRAL ABDOMINAL AREA
08-19-08 8:55 P SCABBING VENTRAL ABDOMINAL AREA
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26534 F 1.5 PPM EYES/EARS/NOSE 08-15-08 8:13 1 DRIED RED MATERIAL AROUND LEFT EYE
08-16-08 13:33 1 DRIED RED MATERIAL AROUND LEFT EYE
08-17-08 11:21 1 WET RED MATERIAL AROUND NOSE
08-17-08 11:22 1 DRIED RED MATERIAL AROUND LEFT EYE
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23246 F 75 PPM DISPOSITION 08-11-08 11:11 P SENT TO NECROPSY; SEX RATIO CRITERIA NOT MET
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26533 F 75 PPM BODY/INTEGUMENT 08-16-08 13:37 P SCABBING VENTRAL ABDOMINAL AREA

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Page 549 of 4796

26502 F 75 PPM EYES/EARS/NOSE 08-14-08 9:18 2 DRIED RED MATERIAL AROUND RIGHT EYE
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26502 F 75 PPM EYES/EARS/NOSE 08-13-08 10:19 2 DRIED RED MATERIAL AROUND RIGHT EYE
08-15-08 8:16 1 DRIED RED MATERIAL AROUND RIGHT EYE
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26451 F 75 PPM EYES/EARS/NOSE 08-14-08 9:18 1 WET RED MATERIAL AROUND NOSE
08-16-08 13:38 1 DRIED RED MATERIAL AROUND NOSE
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08-28-08 9:43 P SCABBING LEFT FORELIMB

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23254 F 750 PPM EXCRETA 07-26-08 6:55 P DECREASED DEFECATION
07-27-08 6:48 P DECREASED DEFECATION
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23239 F 750 PPM BODY/INTEGUMENT 08-16-08 12:45 P SCABBING LEFT FORELIMB
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23258 F 750 PPM BEHAVIOR/CNS 08-01-08 10:21 P BODY FLATTENED
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08-01-08 10:21 1 WET RED MATERIAL UROGENITAL AREA
23258 F 750 PPM CARDIO-PULMONARY 08-01-08 10:21 P INCREASED RESPIRATION
08-03-08 10:34 P DECREASED DEFECATION
23258 F 750 PPM ORAL/DENTAL 08-01-08 10:21 1 WET RED MATERIAL AROUND MOUTH
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TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 595 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
26471 F 750 PPM BODY/INTEGUMENT 08-24-08 8:44 1 HAIR LOSS RIGHT HINDLIMB
Page 596 of 4796
08-28-08 9:48 2 HAIR LOSS RIGHT HINDLIMB

08-29-08 7:00 1 HAIR LOSS RUMP
08-29-08 7:00 1 HAIR LOSS LEFT HINDLIMB
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 597 of 4796

26471 F 750 PPM ORAL/DENTAL 08-16-08 13:47 1 WET RED MATERIAL AROUND MOUTH
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 598 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
07-19-08 10:10 1 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA
Page 599 of 4796

07-22-08 14:45 1 HAIR LOSS RUMP
07-23-08 11:05 1 HAIR LOSS RUMP
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
23255 F 2250 PPM BODY/INTEGUMENT 07-24-08 6:36 1 HAIR LOSS RUMP
Page 600 of 4796

07-26-08 7:03 1 HAIR LOSS LEFT LATERAL ABDOMINAL AREA
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 601 of 4796

07-30-08 9:24 1 HAIR LOSS RIGHT LATERAL THORACIC AREA
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
08-02-08 10:55 1 HAIR LOSS RUMP
08-02-08 10:56 1 HAIR LOSS RIGHT INGUINAL AREA
Page 602 of 4796

08-03-08 10:35 1 HAIR LOSS RUMP
08-03-08 10:36 1 HAIR LOSS UROGENITAL AREA
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
23255 F 2250 PPM BODY/INTEGUMENT 08-04-08 7:54 2 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA
08-05-08 13:49 1 HAIR LOSS RUMP
Page 603 of 4796

08-06-08 13:18 1 HAIR LOSS RUMP
08-07-08 13:37 1 HAIR LOSS RUMP
08-08-08 14:02 1 HAIR LOSS RUMP
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
23255 F 2250 PPM BODY/INTEGUMENT 08-08-08 14:02 1 HAIR LOSS VENTRAL ABDOMINAL AREA
08-09-08 14:04 1 HAIR LOSS RUMP
08-10-08 14:34 1 HAIR LOSS RUMP
Page 604 of 4796

08-11-08 10:44 1 HAIR LOSS RUMP
08-12-08 10:35 1 HAIR LOSS RUMP
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
08-13-08 13:55 1 HAIR LOSS RUMP
08-14-08 13:35 1 HAIR LOSS RUMP
Page 605 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
23255 F 2250 PPM BODY/INTEGUMENT 08-17-08 13:57 1 HAIR LOSS LEFT HINDLIMB
Page 606 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 607 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
23237 F 2250 PPM DISPOSITION 08-06-08 8:10 P FOUND DEAD
Page 608 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 609 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 610 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 611 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 612 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
07-22-08 14:47 1 HAIR LOSS RUMP
Page 613 of 4796
07-23-08 11:06 1 HAIR LOSS RUMP

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 614 of 4796

08-02-08 10:58 1 HAIR LOSS RUMP
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
08-05-08 13:51 1 HAIR LOSS RUMP
08-06-08 13:10 1 HAIR LOSS RUMP
08-07-08 13:39 1 HAIR LOSS RUMP
Page 615 of 4796

08-08-08 14:03 1 HAIR LOSS RUMP
08-09-08 14:05 1 HAIR LOSS RUMP
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 616 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 617 of 4796

07-23-08 11:08 1 HAIR LOSS RUMP
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 618 of 4796

07-26-08 7:08 1 HAIR LOSS LEFT INGUINAL AREA
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 619 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
08-02-08 11:00 1 HAIR LOSS RUMP
Page 620 of 4796

08-03-08 10:39 1 HAIR LOSS RUMP
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
08-05-08 13:52 2 HAIR LOSS RUMP
Page 621 of 4796

08-06-08 13:10 1 HAIR LOSS RUMP
08-07-08 13:21 1 HAIR LOSS RUMP
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
23211 F 2250 PPM BODY/INTEGUMENT 08-07-08 13:21 1 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA
08-08-08 14:04 1 HAIR LOSS RUMP
Page 622 of 4796

08-09-08 14:05 1 HAIR LOSS RUMP
08-10-08 14:38 1 HAIR LOSS RUMP
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
08-11-08 10:46 1 HAIR LOSS RUMP
08-12-08 10:36 1 HAIR LOSS RUMP
Page 623 of 4796

08-13-08 13:58 1 HAIR LOSS RUMP
08-14-08 13:38 1 HAIR LOSS RUMP
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 624 of 4796

08-18-08 13:29 1 HAIR LOSS RUMP
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
23211 F 2250 PPM BODY/INTEGUMENT 08-20-08 14:00 1 HAIR LOSS LEFT INGUINAL AREA
Page 625 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 626 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 627 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 628 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 629 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 630 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 631 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 632 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 633 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 634 of 4796

23227 F 2250 PPM EXCRETA 08-01-08 11:20 P WET RED VAGINAL DISCHARGE
-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 635 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 636 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 637 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
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Page 638 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 639 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 640 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 641 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 642 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 643 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 644 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 645 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 646 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 647 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 648 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 649 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 650 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 651 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 652 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
TABLE RANGE: 07-14-08 TO 09-26-08

-----------------------------------------------------------------------------------------------------------------------------------
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-----------------------------------------------------------------------------------------------------------------------------------
PCRDv4.11
12/16/2008
Page 653 of 4796
FINAL REPORT
Volume 3 of 16
(Appendix A [Tables A2-A17])
STUDY TITLE
STUDY NUMBER
WIL-186056
DATA REQUIREMENT

OECD Guideline 426
STUDY DIRECTOR
26 June 2008
30 September 2009

1407 George Road
SPONSOR

Arlington, VA 22209
Page 654 of 4796

APPENDIX A
TABLES A2-A17
Page 655 of 4796

TABLE A2 (F0 - GESTATION)
SPONSOR:ACC INDIVIDUAL DETAILED CLINICAL OBSERVATIONS GD 10
GROUP: 0 PPM SEX: FEMALES

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23243 23213 23203 23207 23226 23242 23209 23178 23186 23194
-----------------------------------------------------------------------------------------------------------------------------------
GENERAL BODY POSTURE : 1 3 1 1 1 1 2 1 2 2
EASE OF REMOVAL FROM CAGE : 1 1 1 1 1 1 1 1 1 1
EASE OF HANDLING ANIMAL IN HAND: 1 1 1 1 1 1 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
CHROMODACRYORRHEA : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
PALPEBRAL CLOSURE : 1 1 1 1 1 1 1 1 1 1
RESPIRATORY RATE : 1 1 1 1 1 1 1 1 1 1
RESPIRATORY CHARACTER : 1 1 1 1 1 1 1 1 1 1
RED DEPOSITS - EYES : 2 2 2 2 1 2 2 2 2 2
Page 656 of 4796
RED DEPOSITS - NOSE : 2 2 2 2 1 1 2 2 2 2

RED DEPOSITS - MOUTH : 2 2 2 2 2 2 2 2 2 2
CRUSTY DEPOSITS - EYES : 2 2 2 2 2 2 2 2 2 2
CRUSTY DEPOSITS - NOSE : 2 2 2 2 2 2 2 2 2 2
CRUSTY DEPOSITS - MOUTH : 2 2 2 2 2 2 2 2 2 2
MUCOUS MEMBRANES - COLOR : 1 1 1 1 1 1 1 1 1 1
EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
CONVULSIONS-CLONIC : 1 1 1 1 1 1 1 1 1 1
CONVULSIONS-TONIC : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BIZARRE/STEREOTYPIC BEHAVIOR : 1 1 1 1 1 1 1 1 1 1
PUPILLARY RESPONSE : 2 2 2 2 2 2 2 2 2 2
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 1 0 0
-----------------------------------------------------------------------------------------------------------------------------------
-W WITH VOCALIZATION -W/O WITHOUT VOCALIZATION
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23243 23213 23203 23207 23226 23242 23209 23178 23186 23194
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 1 1 1 0 0 1 0 0 0
DEFECATION : 3 0 0 2 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 657 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23182 23240 26521 26449 26473 26452 26528 26491 26512 26454
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 658 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23182 23240 26521 26449 26473 26452 26528 26491 26512 26454
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 0 0 0 0 0 1 0 0 0
DEFECATION : 0 0 0 0 0 1 2 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 659 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26529 26453 26527 26489
-----------------------------------------------------------------------------------------------------------------------------------
GENERAL BODY POSTURE : 3 3 2 1
EASE OF REMOVAL FROM CAGE : 1 1 1 1
EASE OF HANDLING ANIMAL IN HAND: 1 1 1 1
LACRIMATION : 1 1 1 1
CHROMODACRYORRHEA : 1 1 1 1
SALIVATION : 1 1 1 1
PILOERECTION : 1 1 1 1
FUR APPEARANCE : 1 1 1 1
PALPEBRAL CLOSURE : 1 1 1 1
RESPIRATORY RATE : 1 1 1 1
RESPIRATORY CHARACTER : 1 1 1 1
RED DEPOSITS - EYES : 2 2 2 2
Page 660 of 4796
RED DEPOSITS - NOSE : 2 2 2 2

RED DEPOSITS - MOUTH : 2 2 2 2
CRUSTY DEPOSITS - EYES : 2 2 2 2
CRUSTY DEPOSITS - NOSE : 2 2 2 2
CRUSTY DEPOSITS - MOUTH : 2 2 2 2
MUCOUS MEMBRANES - COLOR : 1 1 1 1
EYE COLOR : 1 1 1 1
SKIN COLOR : 1 1 1 1
EYE PROMINENCE : 1 1 1 1
MUSCLE TONE : 1 1 1 1
MOBILITY : 1 1 1 1
GAIT : 1 1 1 1
CONVULSIONS-CLONIC : 1 1 1 1
CONVULSIONS-TONIC : 1 1 1 1
TREMORS : 1 1 1 1
AROUSAL : 3 3 3 3
BIZARRE/STEREOTYPIC BEHAVIOR : 1 1 1 1
PUPILLARY RESPONSE : 2 2 2 2
BACKING : 0 0 0 0
GROOMING : 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26529 26453 26527 26489
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 0 1 0
DEFECATION : 0 0 1 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 661 of 4796
GROUP: 0.15 PPM SEX: FEMALES

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23195 23180 23176 23251 23235 23199 23231 23216 23261 23205
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF HANDLING ANIMAL IN HAND: 2-W/O 1 1 1 1 1 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 662 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 1
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23195 23180 23176 23251 23235 23199 23231 23216 23261 23205
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 0 1 0 0 0 0 1 1 1
DEFECATION : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 663 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23181 23264 26474 26476 26496 26483 26479 26450 26457 26492
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 1 2-W 1 1 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 664 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23181 23264 26474 26476 26496 26483 26479 26450 26457 26492
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 0 0 0 0 0 1 0 1 0
DEFECATION : 0 0 1 0 0 0 2 0 3 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 665 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26493 26488 26520
-----------------------------------------------------------------------------------------------------------------------------------
GENERAL BODY POSTURE : 3 1 2
EASE OF REMOVAL FROM CAGE : 1 2-W 1
EASE OF HANDLING ANIMAL IN HAND: 1 2-W/O 1
LACRIMATION : 1 1 1
CHROMODACRYORRHEA : 1 1 1
SALIVATION : 1 1 1
PILOERECTION : 1 1 1
FUR APPEARANCE : 1 1 1
PALPEBRAL CLOSURE : 1 1 1
RESPIRATORY RATE : 1 1 1
RESPIRATORY CHARACTER : 1 1 1
RED DEPOSITS - EYES : 2 2 2
Page 666 of 4796
RED DEPOSITS - NOSE : 2 1 2

RED DEPOSITS - MOUTH : 2 2 2
CRUSTY DEPOSITS - EYES : 2 2 2
CRUSTY DEPOSITS - NOSE : 2 2 2
CRUSTY DEPOSITS - MOUTH : 2 2 2
MUCOUS MEMBRANES - COLOR : 1 1 1
EYE COLOR : 1 1 1
SKIN COLOR : 1 1 1
EYE PROMINENCE : 1 1 1
MUSCLE TONE : 1 1 1
MOBILITY : 1 1 1
GAIT : 1 1 1
CONVULSIONS-CLONIC : 1 1 1
CONVULSIONS-TONIC : 1 1 1
TREMORS : 1 1 1
AROUSAL : 3 3 3
BIZARRE/STEREOTYPIC BEHAVIOR : 1 1 1
PUPILLARY RESPONSE : 2 2 2
BACKING : 0 0 0
GROOMING : 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26493 26488 26520
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 0 0
DEFECATION : 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 667 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23248 23217 23190 23236 23260 23221 23263 23253 23244 23218
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF HANDLING ANIMAL IN HAND: 1 1 1 1 2-W/O 1 2-W/O 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 668 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 1 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23248 23217 23190 23236 23260 23221 23263 23253 23244 23218
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 1 0 0 0 1 0 3 0 0
DEFECATION : 0 0 0 0 0 0 1 1 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 669 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23208 23252 26510 26519 26468 26475 26532 26507 26480 26482
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 1 1 1 2-W 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 670 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23208 23252 26510 26519 26468 26475 26532 26507 26480 26482
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 1 0 0 0 0 1 0 0 0
DEFECATION : 0 3 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 671 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26522 26517 26514 26534
-----------------------------------------------------------------------------------------------------------------------------------
Page 672 of 4796

EYE COLOR : 1 1 1 1
MOBILITY : 1 1 1 1
GAIT : 1 1 1 1
TREMORS : 1 1 1 1
AROUSAL : 3 3 3 3
BACKING : 0 0 0 0
GROOMING : 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26522 26517 26514 26534
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 673 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23179 23212 23201 23259 23210 23256 23238 23228 23246 23220
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF HANDLING ANIMAL IN HAND: 1 1 1 2-W/O 1 1 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 674 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 1 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23179 23212 23201 23259 23210 23256 23238 23228 23246 23220
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 1 0 0 0 1 0 0 0 0
DEFECATION : 1 4 0 3 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 675 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23183 23184 26516 26497 26495 26499 26494 26533 26502 26451
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 1 1 1 1 1 1 1 2-W/O
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 676 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 1 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23183 23184 26516 26497 26495 26499 26494 26533 26502 26451
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 2 0 1 0 0 0 0 1 0 0
DEFECATION : 1 0 0 0 0 0 0 5 2 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 677 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26535 26456 26518 26459
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 2-W 1 1
Page 678 of 4796

EYE COLOR : 1 1 1 1
MOBILITY : 1 1 1 1
GAIT : 1 1 1 1
TREMORS : 1 1 1 1
AROUSAL : 3 3 3 3
BACKING : 0 0 0 0
GROOMING : 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26535 26456 26518 26459
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 1 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 679 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23198 23233 23241 23254 23239 23245 23223 23191 23247 23230
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF HANDLING ANIMAL IN HAND: 1 1 1 1 2-W/O 2-W/O 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 680 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 1 0 2 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23198 23233 23241 23254 23239 23245 23223 23191 23247 23230
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 1 0 3 0 0 0 0 0
DEFECATION : 4 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 681 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23249 23258 26485 26478 26501 26486 26464 26498 26481 26472
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 1 1 2-W 1 1 1 1 2-W/O
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 682 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 1 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23249 23258 26485 26478 26501 26486 26464 26498 26481 26472
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0 0 1 0 0 0 1
DEFECATION : 0 0 0 0 0 3 0 0 0 5
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 683 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26537 26506 26471 26455
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 2-W/O 2-W 1
Page 684 of 4796

EYE COLOR : 1 1 1 1
MOBILITY : 1 1 1 1
GAIT : 1 1 1 1
TREMORS : 1 1 1 1
AROUSAL : 3 3 3 3
BACKING : 0 0 0 0
GROOMING : 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26537 26506 26471 26455
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 1 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 685 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23255 23237 23215 23214 23192 23219 23211 23189 23204 23257
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 2-W/O 1 1 1 1 1 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 686 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 1 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23255 23237 23215 23214 23192 23219 23211 23189 23204 23257
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0 2 0 0 0 0 0
DEFECATION : 1 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 687 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23234 23227 26509 26448 26508 26463 26504 26465 26477 26511
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 688 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23234 23227 26509 26448 26508 26463 26504 26465 26477 26511
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0 0 0 1 0 0 0
DEFECATION : 0 0 0 8 7 0 1 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 689 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26466 26462 26523 26470
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 2-W 1 1
Page 690 of 4796

EYE COLOR : 1 1 1 1
MOBILITY : 1 1 1 1
GAIT : 1 1 1 1
TREMORS : 1 1 1 1
AROUSAL : 3 3 3 3
BACKING : 0 0 0 0
GROOMING : 0 0 1 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26466 26462 26523 26470
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 1 0 1
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 691 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23243 23213 23203 23207 23226 23242 23209 23178 23186 23194
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 692 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 1 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23243 23213 23203 23207 23226 23242 23209 23178 23186 23194
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 0 0 0 1 0 1 0 0 0
DEFECATION : 0 0 0 1 0 0 0 2 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 693 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23182 23240 26521 26449 26473 26452 26528 26491 26512 26454
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 1 1 1 1 2-W/O 1 1 2-W
EASE OF HANDLING ANIMAL IN HAND: 1 1 1 1 1 1 2-W/O 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 694 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 1 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23182 23240 26521 26449 26473 26452 26528 26491 26512 26454
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 0 0 0 0 0 0 0 0 0
DEFECATION : 7 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 695 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26529 26453 26527 26489
-----------------------------------------------------------------------------------------------------------------------------------
Page 696 of 4796

EYE COLOR : 1 1 1 1
MOBILITY : 1 1 1 1
GAIT : 1 1 1 1
TREMORS : 1 1 1 1
AROUSAL : 3 3 3 3
BACKING : 0 0 0 0
GROOMING : 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26529 26453 26527 26489
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 1 2 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 697 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23195 23180 23176 23251 23235 23199 23231 23216 23261 23205
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 2-W 1 1 1 1 1 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 698 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 1 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23195 23180 23176 23251 23235 23199 23231 23216 23261 23205
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0 0 0 0 0 0 0
DEFECATION : 1 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 699 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23181 23264 26474 26476 26496 26505 26483 26479 26450 26457
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 1 2-W 1 2-W 1 1 1 1
EASE OF HANDLING ANIMAL IN HAND: 1 1 1 2-W 1 2-W 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 700 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23181 23264 26474 26476 26496 26505 26483 26479 26450 26457
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0 1 0 0 1 0 0
DEFECATION : 0 0 3 0 2 0 0 1 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 701 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26492 26493 26488 26520
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 2-W/O 1
EASE OF HANDLING ANIMAL IN HAND: 1 1 2-W/O 1
Page 702 of 4796

EYE COLOR : 1 1 1 1
MOBILITY : 1 1 1 1
GAIT : 1 1 1 1
TREMORS : 1 1 1 1
AROUSAL : 3 3 3 3
BACKING : 0 0 0 0
GROOMING : 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26492 26493 26488 26520
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 2 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 703 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23248 23217 23190 23236 23260 23221 23263 23253 23244 23218
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 2-W/O 1 1 1 1 1 1 1
EASE OF HANDLING ANIMAL IN HAND: 1 1 2-W/O 1 1 1 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 704 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 1 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23248 23217 23190 23236 23260 23221 23263 23253 23244 23218
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 2 2 0 0 0 1 1 0 0
DEFECATION : 0 0 0 0 0 0 3 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 705 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23208 23252 26510 26519 26468 26475 26532 26507 26480 26482
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 2-W 1 1 1 1 1 1 1
EASE OF HANDLING ANIMAL IN HAND: 1 1 2-W 1 1 1 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 706 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 1 1 1 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23208 23252 26510 26519 26468 26475 26532 26507 26480 26482
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 1 0 0 0 0 0 0 0
DEFECATION : 0 0 0 0 0 0 0 0 1 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 707 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26522 26517 26514 26534
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 2-W 1 1 1
Page 708 of 4796

EYE COLOR : 1 1 1 1
MOBILITY : 1 1 1 1
GAIT : 1 1 1 1
TREMORS : 1 1 1 1
AROUSAL : 3 3 3 3
BACKING : 0 0 0 0
GROOMING : 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26522 26517 26514 26534
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 709 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23179 23212 23201 23259 23210 23256 23238 23228 23246 23220
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF HANDLING ANIMAL IN HAND: 1 1 2-W 1 1 1 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 710 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 1 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23179 23212 23201 23259 23210 23256 23238 23228 23246 23220
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0 0 0 0 0 0 0
DEFECATION : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 711 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23183 23184 26516 26497 26495 26499 26494 26533 26502 26451
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 712 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 2 0 0 0 4 0 0 0 1 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23183 23184 26516 26497 26495 26499 26494 26533 26502 26451
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0 0 0 0 1 1 0
DEFECATION : 0 0 3 0 0 0 0 6 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 713 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26535 26456 26518 26459
-----------------------------------------------------------------------------------------------------------------------------------
Page 714 of 4796

EYE COLOR : 1 1 1 1
MOBILITY : 1 1 1 1
GAIT : 1 1 1 1
TREMORS : 1 1 1 1
AROUSAL : 3 3 3 3
BACKING : 0 0 0 0
GROOMING : 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26535 26456 26518 26459
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 2 2 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 715 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23198 23233 23241 23254 23239 23245 23223 23191 23247 23230
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 716 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 1 0 1 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23198 23233 23241 23254 23239 23245 23223 23191 23247 23230
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 1 0 0 0 0 0 0 0
DEFECATION : 1 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 717 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23249 23258 26485 26478 26501 26486 26464 26498 26481 26472
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 2-W 1 1 1 1 1 1 2-W/O 1
EASE OF HANDLING ANIMAL IN HAND: 1 1 1 1 1 1 1 1 2-W/O 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 718 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 1 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23249 23258 26485 26478 26501 26486 26464 26498 26481 26472
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0 0 0 0 0 1 0
DEFECATION : 0 0 0 0 0 4 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 719 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26537 26506 26471 26455
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 2-W/O 1 1
EASE OF HANDLING ANIMAL IN HAND: 1 2-W/O 1 1
Page 720 of 4796

EYE COLOR : 1 1 1 1
MOBILITY : 1 1 1 1
GAIT : 1 1 1 1
TREMORS : 1 1 1 1
AROUSAL : 3 3 3 3
BACKING : 0 0 0 0
GROOMING : 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26537 26506 26471 26455
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 721 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23255 23237 23215 23214 23192 23219 23211 23189 23204 23257
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 722 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23255 23237 23215 23214 23192 23219 23211 23189 23204 23257
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 0 0 0 0 0 0 0 0 0
DEFECATION : 3 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 723 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23234 23227 26509 26448 26508 26463 26504 26465 26477 26511
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 1 2-W 1 1 1 2-W/O 1 2-W
EASE OF HANDLING ANIMAL IN HAND: 1 2-W/O 1 2-W 1 1 1 2-W/O 1 2-W/O
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 724 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 1 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23234 23227 26509 26448 26508 26463 26504 26465 26477 26511
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 1 0 0 0 0 1 0 0 0
DEFECATION : 0 0 0 1 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
Page 725 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26466 26462 26523 26470
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 2-W/O 1 1 1
Page 726 of 4796

EYE COLOR : 1 1 1 1
MOBILITY : 1 1 1 1
GAIT : 1 1 1 1
TREMORS : 1 1 1 1
AROUSAL : 3 3 3 3
BACKING : 0 0 0 0
GROOMING : 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26466 26462 26523 26470
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 1 0
-----------------------------------------------------------------------------------------------------------------------------------
GD= GESTATIONAL DAY
PFOBGv1.52
01/12/2009
R:01/12/2009
Page 727 of 4796
TABLE A3 (F0 - LACTATION)
SPONSOR:ACC INDIVIDUAL DETAILED CLINICAL OBSERVATIONS LD 10

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23243 23213 23203 23207 23226 23242 23209 23178 23186 23194
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 1 1 1 1 1 1 1 2-W/O
EASE OF HANDLING ANIMAL IN HAND: 1 1 1 1 1 2-W/O 1 1 1 2-W/O
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 728 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23243 23213 23203 23207 23226 23242 23209 23178 23186 23194
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 0 0 1 1 1 1 0 0 1
DEFECATION : 1 0 1 1 0 0 0 3 0 1
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 729 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23182 23240 26521 26449 26473 26452 26491 26512 26454 26529
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF HANDLING ANIMAL IN HAND: 1 1 1 1 1 2-W 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 730 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23182 23240 26521 26449 26473 26452 26491 26512 26454 26529
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 0 0 0 0 0 0 1 0 0
DEFECATION : 0 0 0 0 0 3 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 731 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26453 26527 26489
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 1
EASE OF HANDLING ANIMAL IN HAND: 1 1 1
LACRIMATION : 1 1 1
SALIVATION : 1 1 1
Page 732 of 4796

EYE COLOR : 1 1 1
SKIN COLOR : 1 1 1
MUSCLE TONE : 1 1 1
MOBILITY : 1 1 1
GAIT : 1 1 1
TREMORS : 1 1 1
AROUSAL : 3 3 3
BACKING : 0 0 0
GROOMING : 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26453 26527 26489
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0
DEFECATION : 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 733 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23195 23180 23176 23251 23235 23231 23216 23261 23205 23181
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF HANDLING ANIMAL IN HAND: 1 1 1 1 1 1 1 1 2-W/O 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 734 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 1 0 0 0 0 0 1
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23195 23180 23176 23251 23235 23231 23216 23261 23205 23181
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0 0 0 0 1 2 0
DEFECATION : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 735 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23264 26474 26476 26496 26505 26483 26479 26450 26457 26492
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 736 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 2 0 0 0 1 0 1 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23264 26474 26476 26496 26505 26483 26479 26450 26457 26492
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 1 0 0 0 0 0 0
DEFECATION : 0 0 0 2 0 0 0 0 0 4
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 737 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26493 26488 26520
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 2-W/O 1
EASE OF HANDLING ANIMAL IN HAND: 1 3-W/O 1
LACRIMATION : 1 1 1
SALIVATION : 1 1 1
Page 738 of 4796

EYE COLOR : 1 1 1
SKIN COLOR : 1 1 1
MUSCLE TONE : 1 1 1
MOBILITY : 1 1 1
GAIT : 1 1 1
TREMORS : 1 1 1
AROUSAL : 3 3 3
BACKING : 0 0 0
GROOMING : 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26493 26488 26520
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0
DEFECATION : 2 1 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 739 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23248 23217 23190 23236 23260 23221 23263 23253 23244 23218
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 1 1 2-W/O 1 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 740 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23248 23217 23190 23236 23260 23221 23263 23253 23244 23218
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 1 1 0 1 0 1 2 0 0
DEFECATION : 1 0 0 0 0 0 2 1 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 741 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23208 23252 26510 26519 26468 26475 26532 26507 26480 26482
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 742 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 3 1 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23208 23252 26510 26519 26468 26475 26532 26507 26480 26482
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0 0 0 0 0 0 0
DEFECATION : 0 0 0 0 0 0 0 0 6 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 743 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26522 26517 26514 26534
-----------------------------------------------------------------------------------------------------------------------------------
Page 744 of 4796

EYE COLOR : 1 1 1 1
MOBILITY : 1 1 1 1
GAIT : 1 1 1 1
TREMORS : 1 1 1 1
AROUSAL : 3 3 3 3
BACKING : 0 0 0 0
GROOMING : 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26522 26517 26514 26534
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 745 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23179 23212 23201 23259 23210 23256 23238 23228 23220 23183
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 2-W/O 2-W/O 1 1 1 1 1 1 1
LACRIMATION : 1 2 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 746 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 2 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23179 23212 23201 23259 23210 23256 23238 23228 23220 23183
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 1 2 0 1 0 0 0 0
DEFECATION : 0 1 0 2 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 747 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23184 26497 26495 26499 26494 26533 26502 26451 26535 26456
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 748 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23184 26497 26495 26499 26494 26533 26502 26451 26535 26456
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 1 0 0 0 1 1 0 0 0
DEFECATION : 2 3 0 0 0 4 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 749 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26518 26459
-----------------------------------------------------------------------------------------------------------------------------------
GENERAL BODY POSTURE : 1 3
EASE OF REMOVAL FROM CAGE : 1 1
EASE OF HANDLING ANIMAL IN HAND: 1 1
LACRIMATION : 1 1
CHROMODACRYORRHEA : 1 1
SALIVATION : 1 1
PILOERECTION : 1 1
FUR APPEARANCE : 1 1
PALPEBRAL CLOSURE : 1 1
RESPIRATORY RATE : 1 1
RESPIRATORY CHARACTER : 1 1
RED DEPOSITS - EYES : 2 2
Page 750 of 4796
RED DEPOSITS - NOSE : 2 2

RED DEPOSITS - MOUTH : 2 2
CRUSTY DEPOSITS - EYES : 2 2
CRUSTY DEPOSITS - NOSE : 2 2
CRUSTY DEPOSITS - MOUTH : 2 2
MUCOUS MEMBRANES - COLOR : 1 1
EYE COLOR : 1 1
SKIN COLOR : 1 1
EYE PROMINENCE : 1 1
MUSCLE TONE : 1 1
MOBILITY : 1 1
GAIT : 1 1
CONVULSIONS-CLONIC : 1 1
CONVULSIONS-TONIC : 1 1
TREMORS : 1 1
AROUSAL : 3 3
BIZARRE/STEREOTYPIC BEHAVIOR : 1 1
PUPILLARY RESPONSE : 2 2
BACKING : 0 0
GROOMING : 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26518 26459
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 1
DEFECATION : 3 1
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 751 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23198 23233 23241 23239 23245 23223 23191 23247 23230 23249
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 1 1 1 3-W 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 752 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 1 0 0 0 0 1 2 1
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23198 23233 23241 23239 23245 23223 23191 23247 23230 23249
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 0 2 0 0 0 0 1 0 0
DEFECATION : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 753 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23258 26478 26501 26486 26464 26498 26481 26472 26537 26506
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 754 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23258 26478 26501 26486 26464 26498 26481 26472 26537 26506
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 0 0 1 0 0 1 0 0 1
DEFECATION : 6 0 0 3 0 0 1 0 0 7
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 755 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26471 26455
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION : 1 1
SALIVATION : 1 1
PILOERECTION : 1 1
Page 756 of 4796

EYE COLOR : 1 1
SKIN COLOR : 1 1
MUSCLE TONE : 1 1
MOBILITY : 1 1
GAIT : 1 1
TREMORS : 1 1
AROUSAL : 3 3
BACKING : 0 0
GROOMING : 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26471 26455
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0
DEFECATION : 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 757 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23255 23215 23214 23192 23219 23211 23189 23204 23257 23234
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 1 2-W 1 1 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 2 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 2 1 1 1 1
Page 758 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23255 23215 23214 23192 23219 23211 23189 23204 23257 23234
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 0 0 1 0 0 0 0 0 0
DEFECATION : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 759 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23227 26509 26448 26508 26463 26504 26465 26477 26511 26466
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 2-W 1 1 1 2-W/O 1 1 1
EASE OF HANDLING ANIMAL IN HAND: 1 1 1 1 1 1 2-W/O 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 760 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23227 26509 26448 26508 26463 26504 26465 26477 26511 26466
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 1 1 0 1 0 0 0 0
DEFECATION : 0 0 3 1 0 5 0 1 2 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 761 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26462 26523 26470
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 2-W 1
LACRIMATION : 1 1 1
SALIVATION : 1 1 1
Page 762 of 4796

EYE COLOR : 1 1 1
SKIN COLOR : 1 1 1
MUSCLE TONE : 1 1 1
MOBILITY : 1 1 1
GAIT : 1 1 1
TREMORS : 1 1 1
AROUSAL : 3 3 3
BACKING : 0 0 0
GROOMING : 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26462 26523 26470
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0
DEFECATION : 0 0 5
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 763 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23243 23213 23203 23207 23226 23242 23209 23178 23186 23194
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 764 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 2 1 1
AROUSAL : 3 3 3 3 3 3 3 2 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 2 0 0 0 0 0 1 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23243 23213 23203 23207 23226 23242 23209 23178 23186 23194
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 3 0 0 1 2 0 0 1 0 0
DEFECATION : 3 0 0 0 2 0 0 3 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 765 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23182 23240 26521 26449 26473 26452 26491 26512 26454 26529
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 1 2-W/O 2-W/O 1 1 1 1 1
EASE OF HANDLING ANIMAL IN HAND: 1 1 1 2-W/O 1 1 2-W/O 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 766 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23182 23240 26521 26449 26473 26452 26491 26512 26454 26529
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0 1 0 0 0 0 0
DEFECATION : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 767 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26453 26527 26489
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION : 1 1 1
SALIVATION : 1 1 1
Page 768 of 4796

EYE COLOR : 1 1 1
SKIN COLOR : 1 1 1
MUSCLE TONE : 1 1 1
MOBILITY : 1 1 1
GAIT : 1 1 1
TREMORS : 1 1 1
AROUSAL : 3 3 3
BACKING : 0 0 0
GROOMING : 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26453 26527 26489
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0
DEFECATION : 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 769 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23195 23180 23176 23251 23235 23231 23216 23261 23205 23181
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF HANDLING ANIMAL IN HAND: 1 2-W/O 1 1 1 1 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 770 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 1 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23195 23180 23176 23251 23235 23231 23216 23261 23205 23181
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0 0 0 0 0 1 0
DEFECATION : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 771 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23264 26474 26476 26496 26505 26483 26479 26450 26457 26492
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 1 2-W/O 1 1 1 1 1 2-W/O
EASE OF HANDLING ANIMAL IN HAND: 1 1 1 2-W/O 1 1 1 1 1 2-W/O
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 772 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23264 26474 26476 26496 26505 26483 26479 26450 26457 26492
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 1 0 0 0 1 0 1
DEFECATION : 0 0 0 2 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 773 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26493 26488 26520
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 2-W/O 1
LACRIMATION : 1 1 1
SALIVATION : 1 1 1
Page 774 of 4796

EYE COLOR : 1 1 1
SKIN COLOR : 1 1 1
MUSCLE TONE : 1 1 1
MOBILITY : 1 1 1
GAIT : 1 1 1
TREMORS : 1 1 1
AROUSAL : 3 3 3
BACKING : 0 0 0
GROOMING : 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26493 26488 26520
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 1 0
DEFECATION : 0 1 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 775 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23248 23217 23190 23236 23260 23221 23263 23253 23244 23218
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF HANDLING ANIMAL IN HAND: 1 1 1 1 2-W/O 1 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 776 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 1 0 2 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23248 23217 23190 23236 23260 23221 23263 23253 23244 23218
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0 1 0 1 0 0 0
DEFECATION : 0 0 0 0 0 0 1 1 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 777 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23208 23252 26510 26519 26468 26475 26532 26507 26480 26482
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 2-W/O 1 1 1 1 1 1 1 1
EASE OF HANDLING ANIMAL IN HAND: 1 2-W/O 1 1 1 1 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 778 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 2 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23208 23252 26510 26519 26468 26475 26532 26507 26480 26482
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0 0 0 0 0 2 0
DEFECATION : 0 0 2 0 0 0 0 0 5 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 779 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26522 26517 26514 26534
-----------------------------------------------------------------------------------------------------------------------------------
Page 780 of 4796

EYE COLOR : 1 1 1 1
MOBILITY : 1 1 1 1
GAIT : 1 1 1 1
TREMORS : 1 1 1 1
AROUSAL : 3 3 3 3
BACKING : 0 0 0 0
GROOMING : 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26522 26517 26514 26534
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 781 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23179 23212 23201 23259 23210 23256 23238 23228 23220 23183
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 782 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 1 0 1 0 0 0 0 2 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23179 23212 23201 23259 23210 23256 23238 23228 23220 23183
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 1 0 0 0 0 0 0
DEFECATION : 0 3 0 2 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 783 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23184 26497 26495 26499 26494 26533 26502 26451 26535 26456
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 2-W/O 2-W/O 1 2-W/O 1 1 1 1 1
EASE OF HANDLING ANIMAL IN HAND: 1 1 2-W/O 1 2-W/O 1 1 1 1 1
LACRIMATION : 1 1 1 2 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 784 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 1 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23184 26497 26495 26499 26494 26533 26502 26451 26535 26456
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 1 0 0 1 1 0 0 0 1
DEFECATION : 0 3 0 0 0 7 0 0 0 3
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 785 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26518 26459
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 2-W 2-W
LACRIMATION : 1 1
SALIVATION : 1 1
PILOERECTION : 1 1
Page 786 of 4796

EYE COLOR : 1 1
SKIN COLOR : 1 1
MUSCLE TONE : 1 1
MOBILITY : 1 1
GAIT : 1 1
TREMORS : 1 1
AROUSAL : 3 3
BACKING : 0 0
GROOMING : 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26518 26459
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 1
DEFECATION : 4 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 787 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23198 23233 23241 23239 23245 23223 23191 23247 23230 23249
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 788 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 1 2 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23198 23233 23241 23239 23245 23223 23191 23247 23230 23249
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0 0 0 0 0 0 0
DEFECATION : 1 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 789 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23258 26478 26501 26486 26464 26498 26481 26472 26537 26506
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 2-W/O 2-W/O 1 1 1 1 1 1 1 2-W/O
EASE OF HANDLING ANIMAL IN HAND: 2-W/O 2-W 1 1 1 1 1 1 1 2-W/O
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 2 1 1 1 2 1 1 1 1
Page 790 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23258 26478 26501 26486 26464 26498 26481 26472 26537 26506
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 1 1 0 1 0 0 0 0 0 1
DEFECATION : 3 1 0 0 0 0 0 1 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 791 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26471 26455
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION : 1 1
SALIVATION : 1 1
PILOERECTION : 1 1
Page 792 of 4796

EYE COLOR : 1 1
SKIN COLOR : 1 1
MUSCLE TONE : 1 1
MOBILITY : 1 1
GAIT : 1 1
TREMORS : 1 1
AROUSAL : 3 3
BACKING : 0 0
GROOMING : 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26471 26455
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0
DEFECATION : 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 793 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23255 23215 23214 23192 23219 23211 23189 23204 23257 23234
-----------------------------------------------------------------------------------------------------------------------------------
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 794 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 1 1 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23255 23215 23214 23192 23219 23211 23189 23204 23257 23234
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 0 0 0 0 0 0 0
DEFECATION : 0 0 0 0 0 0 0 0 2 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 795 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23227 26509 26448 26508 26463 26504 26465 26477 26511 26466
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF REMOVAL FROM CAGE : 1 1 2-W/O 2-W/O 1 1 1 1 2-W 1
EASE OF HANDLING ANIMAL IN HAND: 1 1 2-W 2-W/O 1 1 1 1 1 1
LACRIMATION : 1 1 1 1 1 1 1 1 1 1
SALIVATION : 1 1 1 1 1 1 1 1 1 1
PILOERECTION : 1 1 1 1 1 1 1 1 1 1
FUR APPEARANCE : 1 1 1 1 1 1 1 1 1 1
Page 796 of 4796

EYE COLOR : 1 1 1 1 1 1 1 1 1 1
SKIN COLOR : 1 1 1 1 1 1 1 1 1 1
EYE PROMINENCE : 1 1 1 1 1 1 1 1 1 1
MUSCLE TONE : 1 1 1 1 1 1 1 1 1 1
MOBILITY : 1 1 1 1 1 1 1 1 1 1
GAIT : 1 1 1 1 1 1 1 1 1 1
TREMORS : 1 1 1 1 1 1 1 1 1 1
AROUSAL : 3 3 3 3 3 3 3 3 3 3
BACKING : 0 0 0 0 0 0 0 0 0 0
GROOMING : 0 0 0 0 0 0 0 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 23227 26509 26448 26508 26463 26504 26465 26477 26511 26466
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0 1 0 1 1 0 1 0
DEFECATION : 0 0 3 2 0 4 5 0 4 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
Page 797 of 4796

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26462 26523 26470
-----------------------------------------------------------------------------------------------------------------------------------
EASE OF HANDLING ANIMAL IN HAND: 1 1 2-W
LACRIMATION : 1 1 1
SALIVATION : 1 1 1
Page 798 of 4796

EYE COLOR : 1 1 1
SKIN COLOR : 1 1 1
MUSCLE TONE : 1 1 1
MOBILITY : 1 1 1
GAIT : 1 1 1
TREMORS : 1 1 1
AROUSAL : 3 3 2
BACKING : 0 0 0
GROOMING : 0 0 0
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL 26462 26523 26470
-----------------------------------------------------------------------------------------------------------------------------------
URINATION : 0 0 0
DEFECATION : 0 0 2
-----------------------------------------------------------------------------------------------------------------------------------
LD= LACTATIONAL DAY
PFOBGv1.52
01/12/2009
R:01/12/2009
Page 799 of 4796
TABLE A4 (F0)
SPONSOR:ACC INDIVIDUAL BODY WEIGHTS DURING GESTATION [G]
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0 3 7 10 14 17 20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM
---------------------------------------
23243 G 261. 274. 294. 309. 328. 362. 414.
23213 G 276. 297. 315. 325. 339. 366. 414.
23203 G 258. 282. 290. 317. 342. 374. 437.
23207 G 232. 247. 242. 267. 293. 326. 362.
23226 G 238. 246. 256. 275. 285. 312. 358.
23242 G 249. 260. 273. 294. 305. 343. 390.
23209 G 251. 262. 278. 297. 319. 345. 394.
23178 G 256. 261. 264. 282. 296. 325. 359.
23186 G 262. 276. 290. 307. 332. 363. 410.
23194 G 271. 280. 300. 326. 343. 379. 433.
23182 G 263. 272. 291. 301. 322. 345. 400.
Page 800 of 4796
23240 G 253. 279. 296. 315. 332. 356. 398.

26521 G 279. 295. 313. 329. 350. 383. 433.
26449 G 264. 283. 301. 317. 343. 376. 417.
26473 G 249. 273. 292. 306. 333. 365. 406.
26452 G 236. 256. 268. 289. 301. 332. 387.
26528 NG 247. 254. 270. 284. 278. 276. 274.
26491 G 250. 261. 286. 305. 324. 355. 399.
26512 G 256. 279. 302. 331. 348. 376. 411.
26454 G 261. 278. 297. 318. 336. 364. 420.
26529 G 271. 283. 296. 309. 338. 366. 420.
26453 G 284. 295. 317. 337. 355. 398. 453.
26527 G 273. 278. 297. 308. 329. 350. 396.
26489 G 257. 271. 300. 318. 344. 367. 425.
MEAN 259. 273. 289. 308. 328. 358. 406.

S.D. 13.4 13.9 18.6 17.9 19.5 20.7 24.4
S.E. 2.8 2.9 3.9 3.7 4.1 4.3 5.1
N 23 23 23 23 23 23 23
G = GRAVID NG = NONGRAVID - WEIGHT(S) NOT INCLUDED IN CALCULATION OF MEAN

TABLE A4 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0 3 7 10 14 17 20
-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM
---------------------------------------
23195 G 261. 279. 307. 321. 341. 363. 412.
23180 G 263. 286. 293. 320. 345. 382. 433.
23176 G 259. 273. 280. 307. 326. 352. 400.
23251 G 247. 269. 275. 302. 328. 354. 403.
23235 G 240. 251. 266. 285. 301. 332. 382.
23199 NG 243. 258. 273. 293. 288. 279. 278.
23231 G 253. 268. 278. 304. 314. 342. 394.
23216 G 259. 284. 303. 324. 349. 379. 437.
23261 G 260. 277. 288. 307. 323. 346. 397.
23205 G 289. 311. 330. 362. 377. 413. 460.
23181 G 271. 283. 311. 318. 345. 375. 417.
Page 801 of 4796
23264 G 259. 286. 304. 318. 334. 369. 411.

26474 G 272. 297. 322. 341. 372. 409. 457.
26476 G 265. 288. 311. 321. 347. 379. 433.
26496 G 248. 272. 290. 301. 331. 362. 396.
26505 G 236. 251. 271. 290. 307. 329. 375.
26483 G 244. 256. 275. 292. 309. 333. 370.
26479 G 253. 261. 279. 308. 311. 345. 375.
26450 G 255. 268. 281. 306. 324. 362. 405.
26457 G 262. 272. 295. 315. 328. 364. 413.
26492 G 267. 278. 301. 322. 340. 372. 421.
26493 G 272. 285. 300. 317. 350. 380. 440.
26488 G 267. 273. 294. 304. 326. 354. 408.
26520 G 248. 259. 275. 291. 306. 336. 384.
MEAN 259. 275. 293. 312. 332. 362. 410.

S.D. 12.0 14.4 17.0 17.1 19.9 22.5 25.1
S.E. 2.5 3.0 3.5 3.6 4.2 4.7 5.2
N 23 23 23 23 23 23 23

TABLE A4 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0 3 7 10 14 17 20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23248 G 258. 275. 298. 319. 353. 384. 439.
23217 G 272. 294. 300. 332. 360. 404. 466.
23190 G 260. 270. 274. 291. 318. 339. 386.
23236 G 242. 258. 268. 284. 310. 335. 385.
23260 G 239. 265. 284. 304. 322. 352. 397.
23221 G 242. 245. 259. 272. 288. 317. 365.
23263 G 252. 260. 271. 289. 302. 333. 377.
23253 G 254. 270. 283. 297. 327. 359. 415.
23244 G 265. 278. 296. 316. 336. 365. 414.
23218 G 269. 285. 306. 317. 341. 373. 430.
23208 G 297. 310. 318. 348. 375. 416. 462.
Page 802 of 4796
23252 G 255. 271. 293. 305. 330. 355. 408.

26510 G 242. 260. 286. 296. 314. 343. 387.
26519 G 257. 283. 297. 317. 342. 375. 416.
26468 G 253. 269. 285. 296. 321. 354. 399.
26475 G 234. 249. 267. 288. 311. 343. 386.
26532 G 238. 248. 262. 279. 297. 330. 373.
26507 G 254. 267. 287. 309. 332. 373. 423.
26480 G 256. 275. 296. 318. 333. 373. 421.
26482 G 259. 268. 285. 299. 324. 355. 398.
26522 G 267. 283. 305. 323. 346. 371. 413.
26517 G 275. 295. 314. 327. 352. 385. 426.
26514 G 259. 272. 288. 299. 318. 348. 388.
26534 G 249. 264. 286. 297. 317. 344. 402.
MEAN 256. 271. 288. 305. 328. 359. 407.

S.D. 13.9 15.3 15.6 18.0 20.5 23.6 25.8
S.E. 2.8 3.1 3.2 3.7 4.2 4.8 5.3
N 24 24 24 24 24 24 24

TABLE A4 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0 3 7 10 14 17 20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23179 G 259. 271. 292. 310. 325. 350. 387.
23212 G 266. 287. 294. 324. 341. 367. 429.
23201 G 257. 266. 277. 301. 327. 360. 399.
23259 G 234. 246. 253. 267. 284. 304. 344.
23210 G 237. 242. 258. 279. 298. 329. 378.
23256 G 247. 258. 267. 288. 303. 332. 385.
23238 G 253. 268. 281. 298. 312. 349. 402.
23228 G 255. 268. 284. 294. 314. 342. 401.
23246 G 262. 278. 287. 304. 320. 351. 378.
23220 G 270. 288. 308. 330. 349. 382. 429.
23183 G 253. 267. 286. 300. 321. 334. 377.
Page 803 of 4796
23184 G 246. 257. 278. 288. 313. 332. 381.

26516 G 254. 263. 283. 291. 305. 338. 378.
26497 G 266. 292. 309. 325. 344. 372. 424.
26495 G 239. 263. 275. 289. 319. 350. 394.
26499 G 231. 246. 267. 290. 311. 344. 401.
26494 G 244. 257. 276. 290. 309. 335. 371.
26533 G 253. 262. 283. 301. 318. 342. 389.
26502 G 255. 265. 284. 305. 319. 353. 418.
26451 G 261. 276. 296. 316. 334. 370. 431.
26535 G 269. 272. 294. 312. 328. 363. 409.
26456 G 272. 282. 302. 320. 333. 377. 428.
26518 G 258. 265. 293. 284. 281. 332. 371.
26459 G 258. 279. 305. 322. 348. 378. 432.
MEAN 254. 267. 285. 301. 319. 349. 397.

S.D. 11.3 13.1 14.6 16.2 17.8 19.0 23.8
S.E. 2.3 2.7 3.0 3.3 3.6 3.9 4.8
N 24 24 24 24 24 24 24

TABLE A4 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0 3 7 10 14 17 20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23198 G 246. 253. 268. 283. 301. 331. 366.
23233 G 266. 273. 293. 304. 325. 361. 391.
23241 G 256. 270. 284. 310. 334. 365. 399.
23254 G 236. 245. 243. 261. 264. 290. 346.
23239 G 241. 249. 263. 291. 311. 333. 377.
23245 G 243. 252. 262. 279. 288. 312. 350.
23223 G 252. 271. 285. 301. 324. 353. 409.
23191 G 254. 237. 255. 276. 301. 331. 381.
23247 G 265. 272. 289. 306. 326. 358. 411.
23230 G 266. 270. 285. 305. 321. 353. 407.
23249 G 254. 245. 279. 288. 314. 333. 378.
Page 804 of 4796
23258 G 243. 248. 257. 271. 286. 277. 322.

26485 G 276. 285. 299. 317. 347. 375. 430.
26478 G 253. 250. 269. 281. 297. 323. 371.
26501 G 249. 248. 272. 284. 304. 345. 392.
26486 G 235. 245. 254. 269. 285. 309. 354.
26464 G 246. 250. 258. 275. 296. 328. 359.
26498 G 251. 262. 276. 302. 324. 357. 405.
26481 G 254. 265. 287. 312. 332. 378. 431.
26472 G 263. 255. 282. 300. 313. 358. 409.
26537 G 267. 282. 304. 323. 350. 388. 439.
26506 G 271. 266. 286. 297. 319. 358. 415.
26471 G 259. 264. 279. 285. 310. 332. 368.
26455 G 254. 257. 273. 280. 301. 325. 370.
MEAN 254. 259. 275. 292. 311. 341. 387.

S.D. 10.9 12.8 15.4 16.4 20.4 27.1 29.8
S.E. 2.2 2.6 3.1 3.4 4.2 5.5 6.1
N 24 24 24 24 24 24 24

TABLE A4 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0 3 7 10 14 17 20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23255 G 237. 240. 242. 262. 270. 314. 345.
23237 G 262. 262. 268. 282. 302. 335. 387.
23215 G 257. 237. 259. 286. 311. 335. 394.
23214 G 250. 245. 237. 261. 278. 299. 355.
23192 G 241. 204. 228. 244. 253. 281. 328.
23219 G 247. 239. 251. 257. 276. 304. 355.
23211 G 251. 250. 259. 274. 284. 307. 342.
23189 G 257. 242. 264. 266. 292. 323. 368.
23204 G 265. 246. 229. 253. 275. 310. 375.
23257 G 288. 285. 291. 312. 317. 338. 390.
23234 G 289. 265. 284. 300. 317. 342. 391.
Page 805 of 4796
23227 G 260. 254. 275. 292. 306. 335. 390.

26509 G 238. 239. 269. 279. 302. 336. 366.
26448 G 265. 270. 282. 297. 326. 360. 393.
26508 G 251. 242. 254. 266. 281. 314. 363.
26463 G 238. 242. 257. 268. 289. 329. 364.
26504 G 244. 228. 252. 275. 297. 330. 370.
26465 G 252. 226. 226. 259. 271. 307. 359.
26477 G 256. 250. 261. 272. 295. 327. 354.
26511 G 260. 253. 271. 285. 304. 331. 373.
26466 G 264. 252. 277. 281. 304. 344. 398.
26462 G 276. 247. 247. 279. 309. 344. 384.
26523 G 266. 249. 274. 283. 301. 332. 391.
26470 G 254. 234. 259. 261. 296. 314. 366.
MEAN 257. 246. 259. 275. 294. 325. 371.

S.D. 13.9 15.9 17.9 16.1 17.6 17.7 18.9
S.E. 2.8 3.2 3.6 3.3 3.6 3.6 3.9
N 24 24 24 24 24 24 24

PGBWv4.07
01/12/2009
TABLE A5 (F0)
SPONSOR:ACC INDIVIDUAL BODY WEIGHT CHANGES DURING GESTATION [G]
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0- 7 7-14 14-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23243 G 13. 20. 15. 19. 34. 52. 33. 34. 86.
23213 G 21. 18. 10. 14. 27. 48. 39. 24. 75.
23203 G 24. 8. 27. 25. 32. 63. 32. 52. 95.
23207 G 15. -5. 25. 26. 33. 36. 10. 51. 69.
23226 G 8. 10. 19. 10. 27. 46. 18. 29. 73.
23242 G 11. 13. 21. 11. 38. 47. 24. 32. 85.
23209 G 11. 16. 19. 22. 26. 49. 27. 41. 75.
23178 G 5. 3. 18. 14. 29. 34. 8. 32. 63.
23186 G 14. 14. 17. 25. 31. 47. 28. 42. 78.
23194 G 9. 20. 26. 17. 36. 54. 29. 43. 90.
23182 G 9. 19. 10. 21. 23. 55. 28. 31. 78.
Page 806 of 4796
23240 G 26. 17. 19. 17. 24. 42. 43. 36. 66.
26521 G 16. 18. 16. 21. 33. 50. 34. 37. 83.
26449 G 19. 18. 16. 26. 33. 41. 37. 42. 74.
26473 G 24. 19. 14. 27. 32. 41. 43. 41. 73.
26452 G 20. 12. 21. 12. 31. 55. 32. 33. 86.
26528 NG 7. 16. 14. -6. -2. -2. 23. 8. -4.
26491 G 11. 25. 19. 19. 31. 44. 36. 38. 75.
26512 G 23. 23. 29. 17. 28. 35. 46. 46. 63.
26454 G 17. 19. 21. 18. 28. 56. 36. 39. 84.
26529 G 12. 13. 13. 29. 28. 54. 25. 42. 82.
26453 G 11. 22. 20. 18. 43. 55. 33. 38. 98.
26527 G 5. 19. 11. 21. 21. 46. 24. 32. 67.
26489 G 14. 29. 18. 26. 23. 58. 43. 44. 81.
MEAN 15. 16. 18. 20. 30. 48. 31. 38. 78.
S.D. 6.1 7.3 5.1 5.4 5.2 7.7 9.9 6.9 9.5
S.E. 1.3 1.5 1.1 1.1 1.1 1.6 2.1 1.4 2.0
N 23 23 23 23 23 23 23 23 23

TABLE A5 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23243 G 153.
23213 G 138.
23203 G 179.
23207 G 130.
23226 G 120.
23242 G 141.
23209 G 143.
23178 G 103.
23186 G 148.
23194 G 162.
23182 G 137.
Page 807 of 4796
23240 G 145.
26521 G 154.
26449 G 153.
26473 G 157.
26452 G 151.
26528 NG 27.
26491 G 149.
26512 G 155.
26454 G 159.
26529 G 149.
26453 G 169.
26527 G 123.
26489 G 168.
MEAN 147.
S.D. 17.0
S.E. 3.6
N 23

TABLE A5 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0- 7 7-14 14-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23195 G 18. 28. 14. 20. 22. 49. 46. 34. 71.
23180 G 23. 7. 27. 25. 37. 51. 30. 52. 88.
23176 G 14. 7. 27. 19. 26. 48. 21. 46. 74.
23251 G 22. 6. 27. 26. 26. 49. 28. 53. 75.
23235 G 11. 15. 19. 16. 31. 50. 26. 35. 81.
23199 NG 15. 15. 20. -5. -9. -1. 30. 15. -10.
23231 G 15. 10. 26. 10. 28. 52. 25. 36. 80.
23216 G 25. 19. 21. 25. 30. 58. 44. 46. 88.
23261 G 17. 11. 19. 16. 23. 51. 28. 35. 74.
23205 G 22. 19. 32. 15. 36. 47. 41. 47. 83.
23181 G 12. 28. 7. 27. 30. 42. 40. 34. 72.
Page 808 of 4796
23264 G 27. 18. 14. 16. 35. 42. 45. 30. 77.
26474 G 25. 25. 19. 31. 37. 48. 50. 50. 85.
26476 G 23. 23. 10. 26. 32. 54. 46. 36. 86.
26496 G 24. 18. 11. 30. 31. 34. 42. 41. 65.
26505 G 15. 20. 19. 17. 22. 46. 35. 36. 68.
26483 G 12. 19. 17. 17. 24. 37. 31. 34. 61.
26479 G 8. 18. 29. 3. 34. 30. 26. 32. 64.
26450 G 13. 13. 25. 18. 38. 43. 26. 43. 81.
26457 G 10. 23. 20. 13. 36. 49. 33. 33. 85.
26492 G 11. 23. 21. 18. 32. 49. 34. 39. 81.
26493 G 13. 15. 17. 33. 30. 60. 28. 50. 90.
26488 G 6. 21. 10. 22. 28. 54. 27. 32. 82.
26520 G 11. 16. 16. 15. 30. 48. 27. 31. 78.
MEAN 16. 17. 19. 20. 30. 47. 34. 39. 78.
S.D. 6.2 6.3 6.7 7.2 4.9 7.1 8.5 7.4 8.1
S.E. 1.3 1.3 1.4 1.5 1.0 1.5 1.8 1.5 1.7
N 23 23 23 23 23 23 23 23 23

TABLE A5 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23195 G 151.
23180 G 170.
23176 G 141.
23251 G 156.
23235 G 142.
23199 NG 35.
23231 G 141.
23216 G 178.
23261 G 137.
23205 G 171.
23181 G 146.
Page 809 of 4796
23264 G 152.
26474 G 185.
26476 G 168.
26496 G 148.
26505 G 139.
26483 G 126.
26479 G 122.
26450 G 150.
26457 G 151.
26492 G 154.
26493 G 168.
26488 G 141.
26520 G 136.
MEAN 151.
S.D. 16.1
S.E. 3.4
N 23

TABLE A5 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0- 7 7-14 14-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23248 G 17. 23. 21. 34. 31. 55. 40. 55. 86.
23217 G 22. 6. 32. 28. 44. 62. 28. 60. 106.
23190 G 10. 4. 17. 27. 21. 47. 14. 44. 68.
23236 G 16. 10. 16. 26. 25. 50. 26. 42. 75.
23260 G 26. 19. 20. 18. 30. 45. 45. 38. 75.
23221 G 3. 14. 13. 16. 29. 48. 17. 29. 77.
23263 G 8. 11. 18. 13. 31. 44. 19. 31. 75.
23253 G 16. 13. 14. 30. 32. 56. 29. 44. 88.
23244 G 13. 18. 20. 20. 29. 49. 31. 40. 78.
23218 G 16. 21. 11. 24. 32. 57. 37. 35. 89.
23208 G 13. 8. 30. 27. 41. 46. 21. 57. 87.
Page 810 of 4796
23252 G 16. 22. 12. 25. 25. 53. 38. 37. 78.
26510 G 18. 26. 10. 18. 29. 44. 44. 28. 73.
26519 G 26. 14. 20. 25. 33. 41. 40. 45. 74.
26468 G 16. 16. 11. 25. 33. 45. 32. 36. 78.
26475 G 15. 18. 21. 23. 32. 43. 33. 44. 75.
26532 G 10. 14. 17. 18. 33. 43. 24. 35. 76.
26507 G 13. 20. 22. 23. 41. 50. 33. 45. 91.
26480 G 19. 21. 22. 15. 40. 48. 40. 37. 88.
26482 G 9. 17. 14. 25. 31. 43. 26. 39. 74.
26522 G 16. 22. 18. 23. 25. 42. 38. 41. 67.
26517 G 20. 19. 13. 25. 33. 41. 39. 38. 74.
26514 G 13. 16. 11. 19. 30. 40. 29. 30. 70.
26534 G 15. 22. 11. 20. 27. 58. 37. 31. 85.
MEAN 15. 16. 17. 23. 32. 48. 32. 40. 79.
S.D. 5.3 5.7 5.8 5.0 5.5 6.1 8.6 8.4 8.9
S.E. 1.1 1.2 1.2 1.0 1.1 1.2 1.7 1.7 1.8
N 24 24 24 24 24 24 24 24 24

TABLE A5 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23248 G 181.
23217 G 194.
23190 G 126.
23236 G 143.
23260 G 158.
23221 G 123.
23263 G 125.
23253 G 161.
23244 G 149.
23218 G 161.
23208 G 165.
Page 811 of 4796
23252 G 153.
26510 G 145.
26519 G 159.
26468 G 146.
26475 G 152.
26532 G 135.
26507 G 169.
26480 G 165.
26482 G 139.
26522 G 146.
26517 G 151.
26514 G 129.
26534 G 153.
MEAN 151.
S.D. 17.3
S.E. 3.5
N 24

TABLE A5 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0- 7 7-14 14-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23179 G 12. 21. 18. 15. 25. 37. 33. 33. 62.
23212 G 21. 7. 30. 17. 26. 62. 28. 47. 88.
23201 G 9. 11. 24. 26. 33. 39. 20. 50. 72.
23259 G 12. 7. 14. 17. 20. 40. 19. 31. 60.
23210 G 5. 16. 21. 19. 31. 49. 21. 40. 80.
23256 G 11. 9. 21. 15. 29. 53. 20. 36. 82.
23238 G 15. 13. 17. 14. 37. 53. 28. 31. 90.
23228 G 13. 16. 10. 20. 28. 59. 29. 30. 87.
23246 G 16. 9. 17. 16. 31. 27. 25. 33. 58.
23220 G 18. 20. 22. 19. 33. 47. 38. 41. 80.
23183 G 14. 19. 14. 21. 13. 43. 33. 35. 56.
Page 812 of 4796
23184 G 11. 21. 10. 25. 19. 49. 32. 35. 68.
26516 G 9. 20. 8. 14. 33. 40. 29. 22. 73.
26497 G 26. 17. 16. 19. 28. 52. 43. 35. 80.
26495 G 24. 12. 14. 30. 31. 44. 36. 44. 75.
26499 G 15. 21. 23. 21. 33. 57. 36. 44. 90.
26494 G 13. 19. 14. 19. 26. 36. 32. 33. 62.
26533 G 9. 21. 18. 17. 24. 47. 30. 35. 71.
26502 G 10. 19. 21. 14. 34. 65. 29. 35. 99.
26451 G 15. 20. 20. 18. 36. 61. 35. 38. 97.
26535 G 3. 22. 18. 16. 35. 46. 25. 34. 81.
26456 G 10. 20. 18. 13. 44. 51. 30. 31. 95.
26518 G 7. 28. -9. -3. 51. 39. 35. -12. 90.
26459 G 21. 26. 17. 26. 30. 54. 47. 43. 84.
MEAN 13. 17. 17. 18. 30. 48. 31. 34. 78.
S.D. 5.7 5.7 7.3 6.2 7.8 9.4 7.0 11.6 12.7
S.E. 1.2 1.2 1.5 1.3 1.6 1.9 1.4 2.4 2.6
N 24 24 24 24 24 24 24 24 24

TABLE A5 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23179 G 128.
23212 G 163.
23201 G 142.
23259 G 110.
23210 G 141.
23256 G 138.
23238 G 149.
23228 G 146.
23246 G 116.
23220 G 159.
23183 G 124.
Page 813 of 4796
23184 G 135.
26516 G 124.
26497 G 158.
26495 G 155.
26499 G 170.
26494 G 127.
26533 G 136.
26502 G 163.
26451 G 170.
26535 G 140.
26456 G 156.
26518 G 113.
26459 G 174.
MEAN 143.
S.D. 18.8
S.E. 3.8
N 24

TABLE A5 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0- 7 7-14 14-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23198 G 7. 15. 15. 18. 30. 35. 22. 33. 65.
23233 G 7. 20. 11. 21. 36. 30. 27. 32. 66.
23241 G 14. 14. 26. 24. 31. 34. 28. 50. 65.
23254 G 9. -2. 18. 3. 26. 56. 7. 21. 82.
23239 G 8. 14. 28. 20. 22. 44. 22. 48. 66.
23245 G 9. 10. 17. 9. 24. 38. 19. 26. 62.
23223 G 19. 14. 16. 23. 29. 56. 33. 39. 85.
23191 G -17. 18. 21. 25. 30. 50. 1. 46. 80.
23247 G 7. 17. 17. 20. 32. 53. 24. 37. 85.
23230 G 4. 15. 20. 16. 32. 54. 19. 36. 86.
23249 G -9. 34. 9. 26. 19. 45. 25. 35. 64.
Page 814 of 4796
23258 G 5. 9. 14. 15. -9. 45. 14. 29. 36.

26485 G 9. 14. 18. 30. 28. 55. 23. 48. 83.
26478 G -3. 19. 12. 16. 26. 48. 16. 28. 74.
26501 G -1. 24. 12. 20. 41. 47. 23. 32. 88.
26486 G 10. 9. 15. 16. 24. 45. 19. 31. 69.
26464 G 4. 8. 17. 21. 32. 31. 12. 38. 63.
26498 G 11. 14. 26. 22. 33. 48. 25. 48. 81.
26481 G 11. 22. 25. 20. 46. 53. 33. 45. 99.
26472 G -8. 27. 18. 13. 45. 51. 19. 31. 96.
26537 G 15. 22. 19. 27. 38. 51. 37. 46. 89.
26506 G -5. 20. 11. 22. 39. 57. 15. 33. 96.
26471 G 5. 15. 6. 25. 22. 36. 20. 31. 58.
26455 G 3. 16. 7. 21. 24. 45. 19. 28. 69.
MEAN 5. 16. 17. 20. 29. 46. 21. 36. 75.

S.D. 8.3 7.1 5.9 5.9 10.8 8.2 8.0 8.2 14.7
S.E. 1.7 1.5 1.2 1.2 2.2 1.7 1.6 1.7 3.0
N 24 24 24 24 24 24 24 24 24

TABLE A5 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23198 G 120.
23233 G 125.
23241 G 143.
23254 G 110.
23239 G 136.
23245 G 107.
23223 G 157.
23191 G 127.
23247 G 146.
23230 G 141.
23249 G 124.
Page 815 of 4796
23258 G 79.
26485 G 154.
26478 G 118.
26501 G 143.
26486 G 119.
26464 G 113.
26498 G 154.
26481 G 177.
26472 G 146.
26537 G 172.
26506 G 144.
26471 G 109.
26455 G 116.
MEAN 133.
S.D. 22.6
S.E. 4.6
N 24

TABLE A5 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0- 7 7-14 14-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23255 G 3. 2. 20. 8. 44. 31. 5. 28. 75.
23237 G 0. 6. 14. 20. 33. 52. 6. 34. 85.
23215 G -20. 22. 27. 25. 24. 59. 2. 52. 83.
23214 G -5. -8. 24. 17. 21. 56. -13. 41. 77.
23192 G -37. 24. 16. 9. 28. 47. -13. 25. 75.
23219 G -8. 12. 6. 19. 28. 51. 4. 25. 79.
23211 G -1. 9. 15. 10. 23. 35. 8. 25. 58.
23189 G -15. 22. 2. 26. 31. 45. 7. 28. 76.
23204 G -19. -17. 24. 22. 35. 65. -36. 46. 100.
23257 G -3. 6. 21. 5. 21. 52. 3. 26. 73.
23234 G -24. 19. 16. 17. 25. 49. -5. 33. 74.
Page 816 of 4796
23227 G -6. 21. 17. 14. 29. 55. 15. 31. 84.
26509 G 1. 30. 10. 23. 34. 30. 31. 33. 64.
26448 G 5. 12. 15. 29. 34. 33. 17. 44. 67.
26508 G -9. 12. 12. 15. 33. 49. 3. 27. 82.
26463 G 4. 15. 11. 21. 40. 35. 19. 32. 75.
26504 G -16. 24. 23. 22. 33. 40. 8. 45. 73.
26465 G -26. 0. 33. 12. 36. 52. -26. 45. 88.
26477 G -6. 11. 11. 23. 32. 27. 5. 34. 59.
26511 G -7. 18. 14. 19. 27. 42. 11. 33. 69.
26466 G -12. 25. 4. 23. 40. 54. 13. 27. 94.
26462 G -29. 0. 32. 30. 35. 40. -29. 62. 75.
26523 G -17. 25. 9. 18. 31. 59. 8. 27. 90.
26470 G -20. 25. 2. 35. 18. 52. 5. 37. 70.
MEAN -11. 13. 16. 19. 31. 46. 2. 35. 77.

S.D. 11.3 11.7 8.5 7.3 6.5 10.4 15.6 9.7 10.2
S.E. 2.3 2.4 1.7 1.5 1.3 2.1 3.2 2.0 2.1
N 24 24 24 24 24 24 24 24 24

TABLE A5 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23255 G 108.
23237 G 125.
23215 G 137.
23214 G 105.
23192 G 87.
23219 G 108.
23211 G 91.
23189 G 111.
23204 G 110.
23257 G 102.
23234 G 102.
Page 817 of 4796
23227 G 130.
26509 G 128.
26448 G 128.
26508 G 112.
26463 G 126.
26504 G 126.
26465 G 107.
26477 G 98.
26511 G 113.
26466 G 134.
26462 G 108.
26523 G 125.
26470 G 112.
MEAN 114.
S.D. 13.5
S.E. 2.8
N 24

PGBWv4.07
01/12/2009
TABLE A6 (F0)
SPONSOR:ACC INDIVIDUAL BODY WEIGHTS DURING LACTATION [G]
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23243 298. 300. 322. 348. 329. 337. 354.
23213 313. 312. 331. 342. 351. 364. 342.
23203 310. 320. 318. 344. 338. 340. 348.
23207 266. 270. 292. 292. 317. 336. 321.
23226 259. 267. 268. 287. 299. 338. 319.
23242 285. 293. 296. 328. 339. 376. 351.
23209 287. 314. 315. 307. 338. 315. 337.
23178 273. 288. 277. 296. 306. 337. 310.
23186 311. 318. 332. 341. 349. 372. 362.
23194 319. 312. 312. 325. 353. 354. 358.
23182 298. 321. 332. 339. 362. 366. 314.
Page 818 of 4796
23240 291. 299. 318. 319. 355. 363. 306.

26521 335. 345. 339. 360. 379. 381. 373.
26449 307. 325. 319. 352. 355. 371. 329.
26473 310. 319. 319. 345. 360. 367. 354.
26452 272. 276. 296. 299. 322. 331. 325.
26491 303. 328. 328. 340. 353. 353. 340.
26512 320. 329. 329. 346. 353. 359. 340.
26454 308. 328. 329. 350. 353. 357. 341.
26529 314. 328. 336. 357. 363. 369. 361.
26453 350. 356. 359. 376. 368. 387. 360.
26527 302. 309. 322. 344. 339. 354. 348.
26489 296. 317. 319. 334. 359. 362. 302.
MEAN 301. 312. 318. 334. 345. 356. 339.

S.D. 21.4 22.2 20.5 23.4 19.8 17.9 19.9
S.E. 4.5 4.6 4.3 4.9 4.1 3.7 4.1
N 23 23 23 23 23 23 23
TABLE A6 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23195 313. 306. 320. 342. 346. 330. 343.
23180 319. 328. 324. 329. 346. 372. 349.
23176 283. 299. 313. 328. 334. 346. 350.
23251 299. 311. 323. 337. 352. 365. 361.
23235 284. 281. 292. 317. 321. 332. 339.
23231 298. 293. 306. 322. 324. 346. 343.
23216 325. 335. 330. 309. 354. 310. 346.
23261 293. 307. 312. 332. 340. 369. 343.
23205 351. 362. 358. 329. 374. 369. 385.
23181 317. 345. 349. 348. 352. 383. 338.
23264 328. 335. 342. 366. 369. 371. 368.
Page 819 of 4796
26474 344. 344. 352. 371. 386. 398. 379.

26476 312. 332. 325. 347. 353. 362. 347.
26496 319. 324. 325. 346. 334. 355. 331.
26505 305. 309. 318. 339. 342. 350. 346.
26483 296. 302. 302. 313. 315. 319. 321.
26479 290. 290. 292. 304. 317. 325. 319.
26450 320. 320. 327. 340. 339. 358. 343.
26457 299. 314. 309. 340. 346. 360. 349.
26492 310. 320. 324. 340. 349. 358. 349.
26493 307. 322. 340. 346. 357. 368. 361.
26488 310. 321. 346. 347. 359. 366. 316.
26520 282. 285. 309. 315. 327. 337. 321.
MEAN 309. 317. 323. 335. 345. 354. 346.

S.D. 18.1 20.4 18.2 16.8 17.9 21.2 17.6
S.E. 3.8 4.3 3.8 3.5 3.7 4.4 3.7
N 23 23 23 23 23 23 23
TABLE A6 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23248 326. 341. 349. 374. 369. 377. 384.
23217 330. 327. 345. 351. 361. 391. 379.
23190 281. 296. 297. 307. 327. 335. 339.
23236 285. 284. 301. 313. 330. 353. 337.
23260 301. 310. 319. 333. 342. 374. 355.
23221 265. 281. 278. 335. 298. 307. 315.
23263 270. 282. 291. 287. 314. 334. 312.
23253 298. 317. 311. 326. 332. 338. 347.
23244 308. 325. 321. 333. 338. 359. 362.
23218 313. 324. 332. 305. 376. 341. 354.
23208 362. 389. 354. 336. 389. 366. 396.
Page 820 of 4796
23252 296. 319. 335. 332. 354. 366. 357.

26510 291. 310. 310. 328. 340. 351. 344.
26519 311. 317. 327. 348. 348. 360. 344.
26468 312. 319. 320. 330. 339. 336. 334.
26475 282. 294. 304. 325. 334. 351. 321.
26532 266. 294. 291. 322. 315. 330. 321.
26507 301. 327. 317. 358. 342. 350. 346.
26480 323. 333. 340. 360. 359. 367. 357.
26482 305. 318. 325. 332. 344. 352. 323.
26522 317. 319. 338. 346. 352. 353. 358.
26517 323. 327. 358. 362. 367. 376. 343.
26514 292. 309. 314. 325. 339. 336. 315.
26534 304. 322. 326. 345. 350. 349. 307.
MEAN 303. 316. 321. 334. 344. 352. 344.

S.D. 22.4 22.6 20.9 19.8 20.5 18.5 23.2
S.E. 4.6 4.6 4.3 4.0 4.2 3.8 4.7
N 24 24 24 24 24 24 24
TABLE A6 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23179 306. 313. 332. 341. 350. 346. 335.
23212 298. 325. 334. 331. 352. 365. 343.
23201 296. 308. 315. 330. 346. 367. 348.
23259 256. 271. 278. 283. 307. 340. 313.
23210 277. 297. 292. 312. 317. 327. 309.
23256 278. 289. 292. 313. 313. 344. 340.
23238 291. 313. 311. 325. 324. 346. 342.
23228 290. 299. 296. 317. 324. 294. 305.
23246 310. 320. SENT TO NECROPSY; SEX RATIO CRITERIA NOT MET
23220 321. 347. 337. 353. 367. 392. 357.
23183 287. 297. 319. 318. 318. 367. 278.
Page 821 of 4796
23184 273. 285. 300. 312. 330. 332. 285.

26497 313. 314. 322. 346. 355. 342. 343.
26495 303. 313. 311. 321. 342. 345. 331.
26499 279. 297. 300. 323. 332. 332. 323.
26494 295. 299. 302. 331. 325. 323. 331.
26533 304. 310. 322. 329. 338. 351. 318.
26502 308. 318. 326. 347. 352. 363. 347.
26451 305. 330. 334. 343. 351. 361. 343.
26535 312. 330. 323. 328. 330. 337. 318.
26456 327. 332. 346. 340. 347. 360. 340.
26518 294. 303. 314. 331. 346. 344. 319.
26459 322. 338. 362. 366. 374. 377. 329.
MEAN 296. 310. 317. 329. 338. 348. 327.

S.D. 18.0 18.5 19.9 17.4 17.6 20.8 20.2
S.E. 3.7 3.8 4.2 3.7 3.8 4.4 4.3
N 24 24 22 22 22 22 22
TABLE A6 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23198 265. 264. 281. 289. 310. 336. 319.
23233 306. 306. 325. 324. 338. 365. 354.
23241 297. 311. 326. 331. 333. 351. 346.
23239 289. 305. 306. 318. 327. 342. 345.
23245 254. 257. 270. 285. 286. 309. 301.
23223 290. 308. 306. 312. 328. 338. 353.
23191 249. 285. 303. 298. 306. 330. 325.
23247 303. 327. 333. 344. 340. 378. 349.
23230 320. 327. 335. 339. 350. 381. 362.
23249 290. 301. 320. 315. 329. 327. 330.
Page 822 of 4796
23258 264. 284. 284. 284. 299. 311. 313.

26478 281. 282. 287. 320. 328. 331. 338.
26501 282. 298. 300. 316. 333. 358. 312.
26486 264. 266. 272. 275. 281. 294. 285.
26464 267. 278. 306. 317. 323. 334. 333.
26498 303. 314. 313. 345. 345. 350. 338.
26481 304. 309. 321. 334. 345. 352. 355.
26472 300. 315. 304. 318. 334. 343. 332.
26537 333. 328. 332. 338. 350. 366. 355.
26506 321. 299. 326. 362. 354. 346. 342.
26471 277. 293. 305. 325. 341. 336. 317.
26455 274. 276. 287. 299. 316. 309. 298.
MEAN 289. 297. 306. 318. 327. 340. 332.

S.D. 24.3 23.4 19.8 22.3 20.1 22.3 21.0
S.E. 5.0 4.8 4.2 4.8 4.3 4.8 4.5
N 24 24 22 22 22 22 22
TABLE A6 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23255 246. 258. 267. 282. 286. 300. 297.
23237 DIED DAY 0
23215 289. 284. 291. 304. 321. 335. 329.
23214 251. 257. 271. 284. 298. 307. 324.
23192 225. 233. 246. 258. 270. 291. 279.
23219 249. 273. 279. 268. 299. 277. 326.
23211 260. 265. 280. 291. 297. 314. 326.
23189 254. 281. 300. 305. 319. 323. 319.
23204 255. 266. 269. 289. 299. 303. 314.
23257 292. 305. 312. 328. 332. 370. 376.
23234 286. 282. 302. 320. 308. 245. 346.
Page 823 of 4796
23227 279. 298. 300. 301. 322. 286. 349.

26509 291. 291. 309. 336. 335. 345. 350.
26448 293. 319. 325. 357. 336. 369. 368.
26508 283. 298. 299. 325. 318. 327. 343.
26463 280. 290. 302. 317. 320. 335. 325.
26504 277. 288. 291. 317. 311. 329. 328.
26465 263. 272. 281. 287. 294. 315. 300.
26477 278. 283. 292. 314. 326. 328. 327.
26511 289. 304. 304. 329. 322. 333. 340.
26466 290. 284. 304. 312. 323. 333. 344.
26462 297. 292. 315. 322. 340. 354. 342.
26523 277. 293. 300. 312. 335. 353. 345.
26470 275. 275. 287. 299. 317. 344. 305.
MEAN 273. 282. 292. 307. 314. 322. 331.

S.D. 19.0 18.7 18.1 22.8 17.9 29.8 22.5
S.E. 4.0 3.9 3.8 4.8 3.7 6.2 4.7
N 23 23 23 23 23 23 23
PLBWv4.05
01/12/2009
R:02/05/2009
TABLE A7 (F0)
SPONSOR:ACC INDIVIDUAL BODY WEIGHT CHANGES DURING LACTATION [G]
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21 1-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23243 2. 22. 26. -19. 8. 17. 56.
23213 -1. 19. 11. 9. 13. -22. 29.
23203 10. -2. 26. -6. 2. 8. 38.
23207 4. 22. 0. 25. 19. -15. 55.
23226 8. 1. 19. 12. 39. -19. 60.
23242 8. 3. 32. 11. 37. -25. 66.
23209 27. 1. -8. 31. -23. 22. 50.
23178 15. -11. 19. 10. 31. -27. 37.
23186 7. 14. 9. 8. 23. -10. 51.
23194 -7. 0. 13. 28. 1. 4. 39.
23182 23. 11. 7. 23. 4. -52. 16.
Page 824 of 4796
23240 8. 19. 1. 36. 8. -57. 15.

26521 10. -6. 21. 19. 2. -8. 38.
26449 18. -6. 33. 3. 16. -42. 22.
26473 9. 0. 26. 15. 7. -13. 44.
26452 4. 20. 3. 23. 9. -6. 53.
26491 25. 0. 12. 13. 0. -13. 37.
26512 9. 0. 17. 7. 6. -19. 20.
26454 20. 1. 21. 3. 4. -16. 33.
26529 14. 8. 21. 6. 6. -8. 47.
26453 6. 3. 17. -8. 19. -27. 10.
26527 7. 13. 22. -5. 15. -6. 46.
26489 21. 2. 15. 25. 3. -60. 6.
MEAN 11. 6. 16. 12. 11. -17. 38.

S.D. 8.5 9.7 10.4 13.6 13.4 21.1 16.7
S.E. 1.8 2.0 2.2 2.8 2.8 4.4 3.5
N 23 23 23 23 23 23 23
TABLE A7 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21 1-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23195 -7. 14. 22. 4. -16. 13. 30.
23180 9. -4. 5. 17. 26. -23. 30.
23176 16. 14. 15. 6. 12. 4. 67.
23251 12. 12. 14. 15. 13. -4. 62.
23235 -3. 11. 25. 4. 11. 7. 55.
23231 -5. 13. 16. 2. 22. -3. 45.
23216 10. -5. -21. 45. -44. 36. 21.
23261 14. 5. 20. 8. 29. -26. 50.
23205 11. -4. -29. 45. -5. 16. 34.
23181 28. 4. -1. 4. 31. -45. 21.
23264 7. 7. 24. 3. 2. -3. 40.
Page 825 of 4796
26474 0. 8. 19. 15. 12. -19. 35.

26476 20. -7. 22. 6. 9. -15. 35.
26496 5. 1. 21. -12. 21. -24. 12.
26505 4. 9. 21. 3. 8. -4. 41.
26483 6. 0. 11. 2. 4. 2. 25.
26479 0. 2. 12. 13. 8. -6. 29.
26450 0. 7. 13. -1. 19. -15. 23.
26457 15. -5. 31. 6. 14. -11. 50.
26492 10. 4. 16. 9. 9. -9. 39.
26493 15. 18. 6. 11. 11. -7. 54.
26488 11. 25. 1. 12. 7. -50. 6.
26520 3. 24. 6. 12. 10. -16. 39.
MEAN 8. 7. 12. 10. 9. -9. 37.

S.D. 8.4 9.0 14.1 12.7 15.6 18.7 15.4
S.E. 1.7 1.9 2.9 2.7 3.3 3.9 3.2
N 23 23 23 23 23 23 23
TABLE A7 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21 1-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23248 15. 8. 25. -5. 8. 7. 58.
23217 -3. 18. 6. 10. 30. -12. 49.
23190 15. 1. 10. 20. 8. 4. 58.
23236 -1. 17. 12. 17. 23. -16. 52.
23260 9. 9. 14. 9. 32. -19. 54.
23221 16. -3. 57. -37. 9. 8. 50.
23263 12. 9. -4. 27. 20. -22. 42.
23253 19. -6. 15. 6. 6. 9. 49.
23244 17. -4. 12. 5. 21. 3. 54.
23218 11. 8. -27. 71. -35. 13. 41.
23208 27. -35. -18. 53. -23. 30. 34.
Page 826 of 4796
23252 23. 16. -3. 22. 12. -9. 61.

26510 19. 0. 18. 12. 11. -7. 53.
26519 6. 10. 21. 0. 12. -16. 33.
26468 7. 1. 10. 9. -3. -2. 22.
26475 12. 10. 21. 9. 17. -30. 39.
26532 28. -3. 31. -7. 15. -9. 55.
26507 26. -10. 41. -16. 8. -4. 45.
26480 10. 7. 20. -1. 8. -10. 34.
26482 13. 7. 7. 12. 8. -29. 18.
26522 2. 19. 8. 6. 1. 5. 41.
26517 4. 31. 4. 5. 9. -33. 20.
26514 17. 5. 11. 14. -3. -21. 23.
26534 18. 4. 19. 5. -1. -42. 3.
MEAN 13. 5. 13. 10. 8. -8. 41.

S.D. 8.3 12.6 17.1 20.8 14.7 16.8 15.1
S.E. 1.7 2.6 3.5 4.2 3.0 3.4 3.1
N 24 24 24 24 24 24 24
TABLE A7 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21 1-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23179 7. 19. 9. 9. -4. -11. 29.
23212 27. 9. -3. 21. 13. -22. 45.
23201 12. 7. 15. 16. 21. -19. 52.
23259 15. 7. 5. 24. 33. -27. 57.
23210 20. -5. 20. 5. 10. -18. 32.
23256 11. 3. 21. 0. 31. -4. 62.
23238 22. -2. 14. -1. 22. -4. 51.
23228 9. -3. 21. 7. -30. 11. 15.
23246 10. SENT TO NECROPSY; SEX RATIO CRITERIA NOT MET
23220 26. -10. 16. 14. 25. -35. 36.
23183 10. 22. -1. 0. 49. -89. -9.
Page 827 of 4796
23184 12. 15. 12. 18. 2. -47. 12.

26497 1. 8. 24. 9. -13. 1. 30.
26495 10. -2. 10. 21. 3. -14. 28.
26499 18. 3. 23. 9. 0. -9. 44.
26494 4. 3. 29. -6. -2. 8. 36.
26533 6. 12. 7. 9. 13. -33. 14.
26502 10. 8. 21. 5. 11. -16. 39.
26451 25. 4. 9. 8. 10. -18. 38.
26535 18. -7. 5. 2. 7. -19. 6.
26456 5. 14. -6. 7. 13. -20. 13.
26518 9. 11. 17. 15. -2. -25. 25.
26459 16. 24. 4. 8. 3. -48. 7.
MEAN 13. 6. 12. 9. 10. -21. 30.

S.D. 7.1 9.1 9.4 7.8 16.8 21.5 18.3
S.E. 1.5 2.0 2.0 1.7 3.6 4.6 3.9
N 24 22 22 22 22 22 22
TABLE A7 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21 1-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23198 -1. 17. 8. 21. 26. -17. 54.
23233 0. 19. -1. 14. 27. -11. 48.
23241 14. 15. 5. 2. 18. -5. 49.
23254 -3. SENT TO NECROPSY; SEX RATIO CRITERIA NOT MET
23239 16. 1. 12. 9. 15. 3. 56.
23245 3. 13. 15. 1. 23. -8. 47.
23223 18. -2. 6. 16. 10. 15. 63.
23191 36. 18. -5. 8. 24. -5. 76.
23247 24. 6. 11. -4. 38. -29. 46.
23230 7. 8. 4. 11. 31. -19. 42.
23249 11. 19. -5. 14. -2. 3. 40.
Page 828 of 4796
23258 20. 0. 0. 15. 12. 2. 49.

26478 1. 5. 33. 8. 3. 7. 57.
26501 16. 2. 16. 17. 25. -46. 30.
26486 2. 6. 3. 6. 13. -9. 21.
26464 11. 28. 11. 6. 11. -1. 66.
26498 11. -1. 32. 0. 5. -12. 35.
26481 5. 12. 13. 11. 7. 3. 51.
26472 15. -11. 14. 16. 9. -11. 32.
26537 -5. 4. 6. 12. 16. -11. 22.
26506 -22. 27. 36. -8. -8. -4. 21.
26471 16. 12. 20. 16. -5. -19. 40.
26455 2. 11. 12. 17. -7. -11. 24.
MEAN 9. 10. 11. 9. 13. -8. 44.

S.D. 11.6 9.7 11.3 7.5 12.6 13.0 15.1
S.E. 2.4 2.1 2.4 1.6 2.7 2.8 3.2
N 24 22 22 22 22 22 22
TABLE A7 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21 1-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23255 12. 9. 15. 4. 14. -3. 51.
23237 DIED DAY 0
23215 -5. 7. 13. 17. 14. -6. 40.
23214 6. 14. 13. 14. 9. 17. 73.
23192 8. 13. 12. 12. 21. -12. 54.
23219 24. 6. -11. 31. -22. 49. 77.
23211 5. 15. 11. 6. 17. 12. 66.
23189 27. 19. 5. 14. 4. -4. 65.
23204 11. 3. 20. 10. 4. 11. 59.
23257 13. 7. 16. 4. 38. 6. 84.
23234 -4. 20. 18. -12. -63. 101. 60.
Page 829 of 4796
23227 19. 2. 1. 21. -36. 63. 70.

26509 0. 18. 27. -1. 10. 5. 59.
26448 26. 6. 32. -21. 33. -1. 75.
26508 15. 1. 26. -7. 9. 16. 60.
26463 10. 12. 15. 3. 15. -10. 45.
26504 11. 3. 26. -6. 18. -1. 51.
26465 9. 9. 6. 7. 21. -15. 37.
26477 5. 9. 22. 12. 2. -1. 49.
26511 15. 0. 25. -7. 11. 7. 51.
26466 -6. 20. 8. 11. 10. 11. 54.
26462 -5. 23. 7. 18. 14. -12. 45.
26523 16. 7. 12. 23. 18. -8. 68.
26470 0. 12. 12. 18. 27. -39. 30.
MEAN 9. 10. 14. 7. 8. 8. 58.

S.D. 9.7 6.7 9.7 12.3 22.0 28.9 13.6
S.E. 2.0 1.4 2.0 2.6 4.6 6.0 2.8
N 23 23 23 23 23 23 23
PLBWv4.05
01/12/2009
R:02/05/2009
TABLE A8 (F0)
SPONSOR:ACC INDIVIDUAL FOOD CONSUMPTION DURING GESTATION [G/ANIMAL/DAY]
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23243 G 21. 25. 25. 26. 28. 31.
23213 G 24. 27. 26. 27. 27. 28.
23203 G 23. 27. 25. 27. 29. 30.
23207 G 20. 19. 22. 25. 25. 24.
23226 G 19. 21. 21. 22. 23. 25.
23242 G 22. 24. 25. 26. 27. 26.
23209 G 20. 24. 24. 27. 26. 27.
23178 G 21. 22. 22. 23. 25. 24.
23186 G 23. 27. 26. 29. 30. 30.
23194 G 23. 26. 28. 28. 30. 32.
23182 G 22. 23. 24. 25. 27. 28.
Page 830 of 4796
23240 G 25. 25. 28. 28. 28. 26.

26521 G 24. 27. 25. 26. 27. 25.
26449 G 22. 25. 26. 26. 26. 24.
26473 G 23. 25. 25. 26. 26. 25.
26452 G 23. 25. 24. 24. 24. 26.
26528 NG 19. 21. 21. 19. 16. 13.
26491 G 22. 25. 25. 27. 26. 25.
26512 G 23. 26. 27. 28. 28. 25.
26454 G 21. 25. 24. 25. 23. 27.
26529 G 23. 23. 24. 27. 25. 29.
26453 G 23. 27. 26. 29. 28. 29.
26527 G 22. 23. 24. 25. 25. 25.
26489 G 21. 24. 25. 25. 26. 26.
MEAN 22. 25. 25. 26. 26. 27.

S.D. 1.4 2.1 1.7 1.8 1.9 2.4
S.E. 0.3 0.4 0.4 0.4 0.4 0.5
N 23 23 23 23 23 23

TABLE A8 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23195 G 24. 28. 27. 28. 30. 30.
23180 G 24. 24. 27. 29. 31. 30.
23176 G 21. 25. 26. 25. 26. 25.
23251 G 22. 26. 26. 28. 27. 25.
23235 G 19. 22. 22. 23. 24. 24.
23199 NG 20. 24. 24. 22. 18. 16.
23231 G 21. 22. 23. 26. 27. 29.
23216 G 26. 30. 29. 33. 32. 31.
23261 G 21. 24. 23. 25. 24. 29.
23205 G 26. 29. 31. 30. 30. 32.
23181 G 24. 25. 25. 28. 31. 30.
Page 831 of 4796
23264 G 24. 24. 25. 26. 29. 28.

26474 G 24. 27. 28. 27. 28. 28.
26476 G 23. 26. 25. 24. 25. 27.
26496 G 22. 25. 24. 27. 27. 26.
26505 G 20. 22. 23. 24. 22. 25.
26483 G 19. 22. 22. 23. 23. 23.
26479 G 20. 24. 25. 25. 28. 23.
26450 G 21. 22. 23. 24. 24. 23.
26457 G 22. 25. 24. 25. 26. 25.
26492 G 23. 26. 24. 26. 27. 25.
26493 G 21. 25. 24. 27. 26. 27.
26488 G 21. 22. 23. 24. 27. 27.
26520 G 20. 22. 24. 23. 25. 24.
MEAN 22. 25. 25. 26. 27. 27.

S.D. 2.0 2.3 2.3 2.5 2.7 2.7
S.E. 0.4 0.5 0.5 0.5 0.6 0.6
N 23 23 23 23 23 23

TABLE A8 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23248 G 24. 28. 28. 31. 34. 32.
23217 G 24. 28. 26. 28. 30. 30.
23190 G 20. 21. 21. 23. 24. 24.
23236 G 21. 24. 23. 25. 26. NA
23260 G 23. 26. 26. 27. 28. 27.
23221 G 18. 21. 20. 22. 25. 24.
23263 G 21. 23. 22. 24. 25. 25.
23253 G 23. 25. 24. 28. 28. 28.
23244 G 23. 26. 26. 28. 28. 29.
23218 G 25. 29. 27. 31. 28. 28.
23208 G 26. 30. 31. 35. 36. 34.
Page 832 of 4796
23252 G 23. 25. 26. 27. 27. 28.

26510 G 21. 26. 26. 26. 25. 23.
26519 G 24. 26. 27. 27. 28. 26.
26468 G 20. 23. 23. 24. 25. 25.
26475 G 20. 23. 23. 26. 27. 25.
26532 G 21. 22. 21. 22. 22. 23.
26507 G 22. 24. 24. 26. 27. 27.
26480 G 24. 26. 26. 26. 28. 26.
26482 G 21. 23. 22. 26. 26. 26.
26522 G 21. 24. 23. 25. 23. 24.
26517 G 24. 25. 26. 26. 28. 25.
26514 G 20. 22. 21. 22. 24. 22.
26534 G 22. 25. 23. 24. 24. 27.
MEAN 22. 25. 24. 26. 27. 26.

S.D. 1.9 2.4 2.7 3.1 3.2 2.9
S.E. 0.4 0.5 0.5 0.6 0.6 0.6
N 24 24 24 24 24 23

NA = NOT APPLICABLE
TABLE A8 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23179 G 23. 26. 24. 26. 27. 28.
23212 G 24. 26. 28. 27. 27. 32.
23201 G 20. 24. 25. 26. 29. 27.
23259 G 17. 19. 20. 21. 22. 23.
23210 G 19. 27. 25. 26. 25. 26.
23256 G 19. 21. 22. 23. 25. 25.
23238 G 22. 23. 22. 24. 25. 26.
23228 G 23. 28. 26. 27. 28. 30.
23246 G 22. 23. 22. 25. 29. 29.
23220 G 22. 25. 25. 27. 28. 25.
23183 G 22. 23. 25. 27. 28. 29.
Page 833 of 4796
23184 G 24. 25. 26. 28. 28. 27.

26516 G 20. 22. 21. 24. 22. 23.
26497 G 23. 25. 26. 23. 22. 24.
26495 G 19. 22. 21. 25. 26. 26.
26499 G 18. 22. 22. 24. 24. 25.
26494 G 19. 22. 21. 24. 23. 23.
26533 G 21. 23. 22. 23. 22. 24.
26502 G 20. 23. 23. 25. 25. 28.
26451 G 22. 25. 25. 26. 26. 28.
26535 G 19. 23. 23. 24. 25. 24.
26456 G 23. 25. 25. 24. 32. 29.
26518 G 21. 24. 21. 15. 28. 27.
26459 G 24. 26. 27. 28. 30. 28.
MEAN 21. 24. 24. 25. 26. 27.

S.D. 2.0 2.1 2.2 2.7 2.7 2.4
S.E. 0.4 0.4 0.5 0.6 0.6 0.5
N 24 24 24 24 24 24

TABLE A8 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23198 G 15. 19. 21. 23. 25. 24.
23233 G 20. 24. 23. 27. 29. 26.
23241 G 20. 23. 25. 28. 29. 27.
23254 G 15. 13. 19. 18. 20. 29.
23239 G 19. 22. 28. 27. 26. 28.
23245 G 18. 23. 24. 25. 25. 23.
23223 G 24. 25. 24. 27. 29. 29.
23191 G 9. 15. 23. 29. 28. 28.
23247 G 22. 25. 25. 28. 28. 29.
23230 G 18. 23. 22. 26. 27. 28.
23249 G 14. 22. 24. 27. 27. 29.
Page 834 of 4796
23258 G 17. 19. 21. 23. 14. 24.

26485 G 23. NA 25. 29. 29. 31.
26478 G 13. 19. 21. 18. 22. 28.
26501 G 14. 20. 20. 22. 24. 26.
26486 G 16. 18. 20. 20. 21. 22.
26464 G 16. 17. 18. 24. 24. 19.
26498 G 16. 19. 21. 24. 28. 27.
26481 G 20. 23. 24. 27. 30. 31.
26472 G 14. 20. 25. 19. 29. 27.
26537 G 23. 23. 24. 28. 31. 31.
26506 G 16. 17. 18. 24. 25. 26.
26471 G 18. 16. 20. 23. 26. 22.
26455 G 19. 21. 21. 24. 24. 22.
MEAN 17. 20. 22. 25. 26. 27.

S.D. 3.6 3.3 2.5 3.4 3.8 3.2
S.E. 0.7 0.7 0.5 0.7 0.8 0.7
N 24 23 24 24 24 24

NA = NOT APPLICABLE
TABLE A8 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23255 G 11. 15. 21. 22. 26. 24.
23237 G 14. 22. 23. 26. 26. 28.
23215 G 9. 24. 23. 25. 27. 29.
23214 G 10. 16. 21. 22. 23. 24.
23192 G 3. 18. 22. 21. 22. 25.
23219 G 8. 21. 16. 22. 22. 24.
23211 G 12. 17. 20. 20. 21. 25.
23189 G 9. 19. 17. 24. 25. 23.
23204 G 10. 13. 21. NA 26. 30.
23257 G 17. 19. 21. 26. 22. 26.
23234 G 10. 20. 19. 24. 25. 28.
Page 835 of 4796
23227 G 13. 19. 25. 25. 28. 28.

26509 G 10. 18. 22. 23. 25. 23.
26448 G 11. 22. 22. 24. 24. 22.
26508 G 8. 23. 29. 22. 22. 24.
26463 G 12. 25. 25. 25. 26. 22.
26504 G 8. 18. 23. 24. 25. 24.
26465 G 12. 16. 27. 15. 23. 26.
26477 G 14. 30. 37. 24. 26. 20.
26511 G 10. 20. 21. 23. 25. 24.
26466 G 9. 22. 19. 24. 25. 26.
26462 G 11. 25. 38. 28. 29. 25.
26523 G 8. 21. 22. 22. 24. 24.
26470 G 13. 19. 19. 24. 22. 25.
MEAN 11. 20. 23. 23. 25. 25.

S.D. 2.8 3.7 5.3 2.5 2.1 2.4
S.E. 0.6 0.8 1.1 0.5 0.4 0.5
N 24 24 24 23 24 24

NA = NOT APPLICABLE
PGFWv4.09
01/12/2009
TABLE A9 (F0)
SPONSOR:ACC INDIVIDUAL FOOD CONSUMPTION DURING LACTATION [G/ANIMAL/DAY]
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23243 36. 43. 52. 62. 68. 70.
23213 38. 46. 59. 65. 68. 55.
23203 34. 40. 52. 59. 64. 70.
23207 31. 39. 48. 61. 62. 66.
23226 NA 35. 52. 59. 68. 74.
23242 35. 41. 53. 63. 70. 78.
23209 42. 42. 48. 67. 61. 81.
23178 35. 37. 50. 62. 65. 72.
23186 34. 42. 51. 60. 62. 69.
23194 NA 38. 52. 63. 69. 75.
23182 42. 48. 61. 66. 82. 68.
Page 836 of 4796
23240 NA NA 61. 66. 77. 69.

26521 NA 48. 57. 76. 71. 74.
26449 33. 37. 49. 62. 63. 68.
26473 36. 41. 50. 64. 57. 72.
26452 34. 37. 58. 67. 67. 79.
26491 44. 41. 52. 55. 59. 73.
26512 31. 38. 53. 59. 61. 65.
26454 42. 43. 55. 57. 58. 70.
26529 49. 48. 64. 68. 69. 80.
26453 40. 42. 53. 59. 62. 68.
26527 42. 39. 51. 56. 59. 65.
26489 41. 42. 61. 62. 73. 60.
MEAN 38. 41. 54. 63. 66. 70.

S.D. 4.9 3.7 4.6 4.6 6.2 6.2
S.E. 1.1 0.8 1.0 1.0 1.3 1.3
N 19 22 23 23 23 23
NA = NOT APPLICABLE
TABLE A9 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23195 NA 58. 62. 69. 67. 90.
23180 NA 41. 54. 66. 67. 83.
23176 33. NA 57. 65. 65. 77.
23251 42. 46. 59. 70. 74. 82.
23235 27. 33. 45. 52. 59. 66.
23231 34. 39. 55. 61. 67. 85.
23216 43. 42. 53. 79. 68. 90.
23261 33. 40. 49. 65. 72. 75.
23205 41. 46. 48. 71. 73. 94.
23181 40. 49. 61. 62. 81. 75.
23264 33. 41. 51. 58. 58. 65.
Page 837 of 4796
26474 34. 40. 50. 68. 64. 67.

26476 36. 44. 50. 64. 60. 76.
26496 35. 44. 50. 60. 64. 71.
26505 38. 41. 54. 58. 66. 79.
26483 NA 38. 53. 59. 60. 71.
26479 36. 39. NA 62. 66. 75.
26450 45. 43. 55. 58. 62. 62.
26457 36. 40. 54. 64. 63. 67.
26492 31. 41. 47. 61. 60. 61.
26493 42. 45. 56. 65. 64. 75.
26488 35. 48. 57. 58. 69. 71.
26520 32. 42. 55. 60. 73. 71.
MEAN 36. 43. 53. 63. 66. 75.

S.D. 4.6 4.9 4.4 5.7 5.6 9.0
S.E. 1.0 1.1 0.9 1.2 1.2 1.9
N 20 22 22 23 23 23
NA = NOT APPLICABLE
TABLE A9 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23248 41. 50. 59. 72. 76. 67.
23217 34. 40. 55. 66. 67. 73.
23190 35. 37. 52. 63. 64. 75.
23236 NA 37. 49. 57. 59. 64.
23260 30. 38. 48. 56. 62. 69.
23221 36. 41. 63. 58. 68. 85.
23263 NA 41. 49. 63. 66. 71.
23253 44. 43. 52. 65. 68. 79.
23244 40. 37. 49. 53. 63. 68.
23218 NA 47. 52. 78. 69. 95.
23208 47. 46. 46. 73. 71. 87.
Page 838 of 4796
23252 38. 43. 53. 62. 71. 64.

26510 35. 41. 45. 58. 57. 56.
26519 34. 49. 59. 74. 68. 76.
26468 31. 40. 46. 58. 56. 66.
26475 32. 40. 56. 64. 67. 73.
26532 31. 40. 50. 60. 59. 68.
26507 37. 41. 52. 62. 61. 69.
26480 44. 42. 55. 63. 63. 68.
26482 33. 38. 48. 56. 60. 69.
26522 NA 44. 56. 58. 61. 70.
26517 40. 50. 61. 61. 75. 69.
26514 35. 42. 53. 53. 63. 65.
26534 45. 46. 62. 60. 72. 65.
MEAN 37. 42. 53. 62. 65. 71.

S.D. 5.1 4.0 5.2 6.5 5.5 8.4
S.E. 1.1 0.8 1.1 1.3 1.1 1.7
N 20 24 24 24 24 24
NA = NOT APPLICABLE
TABLE A9 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23179 34. 45. 58. 63. 63. 72.
23212 NA 60. 58. 62. 73. NA
23201 39. 40. 50. 67. 63. 69.
23259 36. 43. 52. 68. 76. 81.
23210 39. 41. 56. 61. 64. 78.
23256 35. 39. 49. 57. 57. 69.
23238 39. 39. 52. 57. 65. 76.
23228 38. 41. 54. 63. 60. 78.
23246 NA SENT TO NECROPSY; SEX RATIO CRITERIA NOT MET
23220 47. 45. 59. 66. 77. 80.
23183 37. 50. 56. 62. 75. 71.
Page 839 of 4796
23184 35. 47. 51. 62. 76. 65.

26497 32. 44. 52. 68. 63. 78.
26495 40. 45. 51. 68. 66. NA
26499 39. 44. 59. 65. 67. 74.
26494 28. 36. 47. 58. 55. 63.
26533 41. 44. 55. 58. 59. 73.
26502 39. 47. 57. 61. 65. 76.
26451 38. 43. 55. 58. 65. 73.
26535 40. 39. 49. 52. 56. 59.
26456 45. 47. 53. 59. 62. 69.
26518 35. 46. 60. 64. 73. 72.
26459 35. 49. 58. 61. 77. 71.
MEAN 38. 44. 54. 62. 66. 72.

S.D. 4.1 5.0 3.8 4.2 7.1 5.7
S.E. 0.9 1.1 0.8 0.9 1.5 1.3
N 21 22 22 22 22 20
NA = NOT APPLICABLE
TABLE A9 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23198 34. 43. 52. 61. 66. 81.
23233 25. 37. 46. 56. 63. 73.
23241 42. 48. 52. 53. 59. 77.
23239 38. 46. 52. 74. 74. 91.
23245 32. 37. 48. 53. 60. 71.
23223 40. 44. 54. 72. 75. 90.
23191 37. 47. 57. 62. 61. 71.
23247 40. 46. 53. 62. 74. 77.
23230 35. 33. 35. 62. 58. 65.
23249 43. 56. 43. 33. 41. 40.
Page 840 of 4796
23258 33. 36. 43. 40. 59. 57.

26478 27. 40. 50. 66. 59. 82.
26501 35. 34. 46. 59. 59. 59.
26486 26. 35. 45. 52. 55. 66.
26464 28. 44. 54. 63. 62. 71.
26498 28. 39. 51. 66. 60. 72.
26481 29. 43. 53. 59. 60. 79.
26472 32. 37. 41. 63. 60. 65.
26537 38. 44. 59. 67. 71. 73.
26506 26. 48. 59. 77. 70. 71.
26471 33. 44. 57. 57. 69. 66.
26455 49. NA NA 51. 58. 63.
MEAN 34. 42. 50. 59. 62. 71.

S.D. 6.7 5.7 6.3 10.2 7.7 11.2
S.E. 1.4 1.3 1.4 2.2 1.6 2.4
N 23 21 21 22 22 22
NA = NOT APPLICABLE
TABLE A9 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23255 30. 36. 47. 53. 57. 67.
23237 DIED DAY 0
23215 33. 43. 54. 66. 70. 84.
23214 30. 42. 51. 61. 68. 91.
23192 28. 36. 46. 50. 51. 63.
23219 45. 49. 52. 68. 67. 90.
23211 NA 45. 46. 50. 57. 75.
23189 46. 48. 52. 60. 63. 77.
23204 NA 38. 58. 59. 59. 73.
23257 34. 41. 50. 56. 68. 75.
23234 NA 37. 52. 53. 37. 80.
Page 841 of 4796
23227 33. 44. 46. 62. 66. 84.

26509 29. 41. 48. 62. 57. 74.
26448 50. 48. 55. 59. 71. 83.
26508 NA NA NA 69. 70. 89.
26463 38. 44. 54. 62. 65. 65.
26504 30. 40. 45. 54. 60. 69.
26465 NA 38. 49. 55. 64. 73.
26477 NA 36. NA 60. 67. 76.
26511 38. 40. 57. 59. 65. 82.
26466 38. 46. 57. 60. 65. 81.
26462 38. NA NA 62. 66. 66.
26523 33. 40. 48. 58. 59. 70.
26470 34. 38. 49. 54. 65. 67.
MEAN 36. 41. 51. 59. 62. 76.

S.D. 6.4 4.1 4.0 5.1 7.5 8.3
S.E. 1.5 0.9 0.9 1.1 1.6 1.7
N 17 21 20 23 23 23
NA = NOT APPLICABLE
PLFWv4.10
01/12/2009
R:02/05/2009
TABLE A10 (F0)
SPONSOR:ACC INDIVIDUAL CALCULATED GESTATION TEST SUBSTANCE CONSUMPTION [MG/KG/DAY]
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23243 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23213 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23203 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23207 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23226 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23242 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23209 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23178 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23186 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23194 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23182 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Page 842 of 4796
23240 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00

26521 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26449 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26473 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26452 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26528 NG 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26491 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26512 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26454 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26529 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26453 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26527 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26489 G 0.00 0.00 0.00 0.00 0.00 0.00 0.00
MEAN 0.00 0.00 0.00 0.00 0.00 0.00 0.00

S.D. 0.000 0.000 0.000 0.000 0.000 0.000 0.000
S.E. 0.000 0.000 0.000 0.000 0.000 0.000 0.000
N 23 23 23 23 23 23 23

TABLE A10 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23195 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23180 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23176 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23251 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23235 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23199 NG 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23231 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23216 G 0.01 0.02 0.01 0.01 0.01 0.01 0.01
23261 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23205 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
23181 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
Page 843 of 4796
23264 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01

26474 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
26476 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
26496 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
26505 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
26483 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
26479 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
26450 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
26457 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
26492 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
26493 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
26488 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
26520 G 0.01 0.01 0.01 0.01 0.01 0.01 0.01
MEAN 0.01 0.01 0.01 0.01 0.01 0.01 0.01

S.D. 0.001 0.001 0.001 0.001 0.001 0.001 0.001
S.E. 0.000 0.000 0.000 0.000 0.000 0.000 0.000
N 23 23 23 23 23 23 23

TABLE A10 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23248 G 0.14 0.15 0.14 0.14 0.14 0.12 0.13
23217 G 0.13 0.14 0.12 0.12 0.12 0.10 0.12
23190 G 0.11 0.12 0.11 0.11 0.11 0.10 0.11
23236 G 0.12 0.14 0.12 0.13 0.12 NA NA
23260 G 0.14 0.14 0.13 0.13 0.12 0.11 0.13
23221 G 0.11 0.12 0.11 0.12 0.12 0.11 0.11
23263 G 0.12 0.13 0.12 0.12 0.12 0.11 0.12
23253 G 0.13 0.14 0.12 0.14 0.12 0.11 0.12
23244 G 0.13 0.14 0.13 0.13 0.12 0.11 0.12
23218 G 0.14 0.14 0.13 0.14 0.12 0.10 0.13
23208 G 0.13 0.14 0.14 0.14 0.14 0.12 0.13
Page 844 of 4796
23252 G 0.13 0.13 0.13 0.13 0.12 0.11 0.12

26510 G 0.13 0.14 0.13 0.13 0.11 0.09 0.12
26519 G 0.14 0.13 0.13 0.12 0.12 0.10 0.12
26468 G 0.11 0.12 0.12 0.12 0.11 0.10 0.11
26475 G 0.13 0.13 0.12 0.13 0.12 0.10 0.12
26532 G 0.13 0.13 0.12 0.11 0.10 0.10 0.11
26507 G 0.13 0.13 0.12 0.12 0.11 0.10 0.12
26480 G 0.14 0.13 0.13 0.12 0.12 0.10 0.12
26482 G 0.12 0.13 0.11 0.12 0.11 0.10 0.11
26522 G 0.12 0.12 0.11 0.11 0.10 0.09 0.11
26517 G 0.13 0.12 0.12 0.12 0.11 0.09 0.11
26514 G 0.11 0.12 0.11 0.11 0.11 0.09 0.11
26534 G 0.13 0.13 0.12 0.12 0.11 0.11 0.12
MEAN 0.13 0.13 0.12 0.12 0.12 0.10 0.12

S.D. 0.008 0.009 0.009 0.009 0.009 0.007 0.007
S.E. 0.002 0.002 0.002 0.002 0.002 0.002 0.002
N 24 24 24 24 24 23 23

NA = NOT APPLICABLE
TABLE A10 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23179 G 6.51 6.79 6.06 6.14 5.93 5.63 6.11
23212 G 6.51 6.78 6.72 6.09 5.79 6.03 6.21
23201 G 5.64 6.56 6.40 6.27 6.33 5.27 6.00
23259 G 5.21 5.79 5.67 5.58 5.61 5.40 5.49
23210 G 5.85 7.95 6.89 6.69 6.06 5.45 6.39
23256 G 5.74 6.07 6.04 5.90 5.83 5.30 5.72
23238 G 6.24 6.22 5.70 5.78 5.67 5.26 5.70
23228 G 6.60 7.54 6.66 6.66 6.40 5.99 6.54
23246 G 6.11 5.97 5.67 5.89 6.48 5.90 5.95
23220 G 6.00 6.35 5.88 5.96 5.75 4.69 5.69
23183 G 6.44 6.17 6.40 6.40 6.41 6.05 6.25
Page 845 of 4796
23184 G 7.06 6.87 6.89 6.93 6.59 5.68 6.57

26516 G 5.90 6.11 5.57 5.91 5.06 4.75 5.48
26497 G 6.18 6.18 6.07 5.16 4.61 4.46 5.34
26495 G 5.78 5.99 5.50 6.11 5.83 5.18 5.67
26499 G 5.76 6.29 5.84 5.99 5.50 5.03 5.64
26494 G 5.59 6.12 5.56 6.01 5.36 4.89 5.55
26533 G 6.02 6.40 5.65 5.63 5.08 4.99 5.55
26502 G 5.67 6.15 5.77 5.89 5.58 5.45 5.66
26451 G 6.05 6.49 6.21 6.00 5.61 5.24 5.83
26535 G 5.27 6.16 5.69 5.57 5.43 4.73 5.40
26456 G 6.32 6.36 6.11 5.57 6.76 5.40 5.96
26518 G 5.93 6.38 5.54 3.85 6.93 5.76 5.61
26459 G 6.61 6.61 6.46 6.21 6.13 5.12 6.08
MEAN 6.04 6.43 6.04 5.93 5.86 5.32 5.85

S.D. 0.443 0.491 0.444 0.592 0.570 0.445 0.355
S.E. 0.090 0.100 0.091 0.121 0.116 0.091 0.072
N 24 24 24 24 24 24 24

TABLE A10 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23198 G 46.08 53.26 58.06 59.08 59.33 52.36 54.34
23233 G 56.58 62.28 56.96 63.20 64.13 52.52 58.84
23241 G 57.98 60.92 63.97 64.64 62.94 52.36 59.89
23254 G 47.81 38.42 55.57 52.14 55.04 67.62 51.80
23239 G 58.16 65.18 74.92 67.90 61.33 58.46 63.56
23245 G 54.55 67.12 66.54 66.80 62.50 52.86 61.33
23223 G 68.83 67.45 61.43 64.20 63.52 57.09 62.66
23191 G 26.49 44.20 65.90 74.74 67.24 58.99 56.50
23247 G 62.38 66.85 63.85 65.27 60.68 57.21 61.76
23230 G 49.45 60.81 56.77 62.30 60.09 55.26 56.97
23249 G 41.09 62.26 64.36 67.27 63.36 61.88 60.14
Page 846 of 4796
23258 G 52.94 55.70 60.60 62.61 36.42 60.10 54.74

26485 G 62.38 NA 60.88 64.38 59.56 57.15 61.56
26478 G 37.79 54.92 56.37 46.71 54.02 59.80 51.11
26501 G 43.25 56.97 54.85 55.49 55.47 52.25 52.52
26486 G 48.97 53.35 57.36 52.80 53.86 49.78 51.94
26464 G 48.39 48.72 51.58 62.39 56.90 40.76 51.01
26498 G 47.74 51.58 54.50 58.11 62.40 52.50 54.02
26481 G 58.75 63.18 60.10 62.89 64.08 56.86 60.07
26472 G 40.54 55.87 64.43 47.11 64.09 52.16 52.98
26537 G 62.84 58.24 56.63 62.96 63.68 56.83 59.35
26506 G 43.77 45.52 46.31 59.05 56.12 49.81 49.60
26471 G 52.57 43.51 52.31 57.98 59.98 47.15 51.58
26455 G 55.77 60.14 57.85 62.61 56.72 47.48 56.07
MEAN 51.05 56.37 59.25 60.94 59.31 54.55 56.43

S.D. 9.564 8.137 5.944 6.533 6.122 5.599 4.332
S.E. 1.952 1.697 1.213 1.334 1.250 1.143 0.884
N 24 23 24 24 24 24 24

NA = NOT APPLICABLE
TABLE A10 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
PREGNANCY
STATUS DAY 0- 3 3- 7 7-10 10-14 14-17 17-20 0-20
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23255 G 100.67 137.70 184.54 181.87 197.80 161.64 159.57
23237 G 117.41 184.68 188.19 196.49 181.35 172.46 172.28
23215 G 84.98 213.21 192.62 190.33 188.08 179.01 174.62
23214 G 87.91 144.72 189.76 185.76 176.81 167.40 157.09
23192 G 33.68 187.49 209.75 190.15 188.17 182.29 165.10
23219 G 77.13 188.26 144.65 181.53 170.69 161.64 154.73
23211 G 107.78 150.30 166.07 163.31 162.41 173.34 153.34
23189 G 84.13 171.20 147.15 195.57 185.33 149.78 156.17
23204 G 88.06 120.78 199.15 NA 202.54 199.24 158.78
23257 G 133.52 146.47 159.19 182.43 148.88 162.76 154.60
23234 G 81.22 161.89 148.95 175.05 172.96 169.88 151.88
Page 847 of 4796
23227 G 116.71 163.75 195.79 184.37 194.24 175.84 170.39

26509 G 91.24 159.46 177.95 178.13 178.65 149.56 156.80
26448 G 95.31 179.35 170.98 175.16 159.59 131.47 152.26
26508 G 76.03 210.94 248.11 180.99 166.39 159.53 171.81
26463 G 112.50 225.45 214.29 199.96 189.31 144.99 180.34
26504 G 73.13 171.09 193.57 190.78 181.80 152.17 160.97
26465 G 112.97 159.30 253.57 127.35 179.06 175.68 161.24
26477 G 127.44 266.40 315.18 188.48 185.72 134.35 198.92
26511 G 84.83 171.76 172.64 173.81 174.82 155.52 155.84
26466 G 78.48 187.16 153.22 180.76 171.31 157.68 155.27
26462 G 97.49 227.72 327.92 216.20 202.12 154.53 198.20
26523 G 72.79 182.84 177.73 167.60 172.96 151.43 153.68
26470 G 116.84 171.13 167.29 189.85 159.86 163.26 160.36
MEAN 93.84 178.46 195.76 182.43 178.79 161.89 163.93

S.D. 21.962 32.511 47.726 16.434 13.757 15.350 13.189
S.E. 4.483 6.636 9.742 3.427 2.808 3.133 2.692
N 24 24 24 23 24 24 24

NA = NOT APPLICABLE
PGFWv4.09
01/12/2009
R:01/12/2009
TABLE A11 (F0)
SPONSOR:ACC INDIVIDUAL CALCULATED LACTATION TEST SUBSTANCE CONSUMPTION [MG/KG/DAY]
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21 1-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23243 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23213 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23203 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23207 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23226 NA 0.00 0.00 0.00 0.00 0.00 NA
23242 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23209 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23178 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23186 0.00 0.00 0.00 0.00 0.00 0.00 0.00
23194 NA 0.00 0.00 0.00 0.00 0.00 NA
23182 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Page 848 of 4796
23240 NA NA 0.00 0.00 0.00 0.00 NA

26521 NA 0.00 0.00 0.00 0.00 0.00 NA
26449 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26473 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26452 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26491 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26512 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26454 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26529 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26453 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26527 0.00 0.00 0.00 0.00 0.00 0.00 0.00
26489 0.00 0.00 0.00 0.00 0.00 0.00 0.00
MEAN 0.00 0.00 0.00 0.00 0.00 0.00 0.00

S.D. 0.000 0.000 0.000 0.000 0.000 0.000 0.000
S.E. 0.000 0.000 0.000 0.000 0.000 0.000 0.000
N 19 22 23 23 23 23 19
NA = NOT APPLICABLE
TABLE A11 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21 1-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23195 NA 0.03 0.03 0.03 0.03 0.04 NA
23180 NA 0.02 0.02 0.03 0.03 0.03 NA
23176 0.02 NA 0.03 0.03 0.03 0.03 0.03
23251 0.02 0.02 0.03 0.03 0.03 0.03 0.03
23235 0.01 0.02 0.02 0.02 0.03 0.03 0.02
23231 0.02 0.02 0.03 0.03 0.03 0.04 0.03
23216 0.02 0.02 0.02 0.04 0.03 0.04 0.03
23261 0.02 0.02 0.02 0.03 0.03 0.03 0.03
23205 0.02 0.02 0.02 0.03 0.03 0.04 0.03
23181 0.02 0.02 0.03 0.03 0.03 0.03 0.03
23264 0.01 0.02 0.02 0.02 0.02 0.03 0.02
Page 849 of 4796
26474 0.01 0.02 0.02 0.03 0.02 0.03 0.02

26476 0.02 0.02 0.02 0.03 0.03 0.03 0.02
26496 0.02 0.02 0.02 0.03 0.03 0.03 0.02
26505 0.02 0.02 0.02 0.03 0.03 0.03 0.03
26483 NA 0.02 0.03 0.03 0.03 0.03 NA
26479 0.02 0.02 NA 0.03 0.03 0.03 0.03
26450 0.02 0.02 0.02 0.03 0.03 0.03 0.02
26457 0.02 0.02 0.02 0.03 0.03 0.03 0.02
26492 0.01 0.02 0.02 0.03 0.03 0.03 0.02
26493 0.02 0.02 0.02 0.03 0.03 0.03 0.03
26488 0.02 0.02 0.02 0.02 0.03 0.03 0.03
26520 0.02 0.02 0.03 0.03 0.03 0.03 0.03
MEAN 0.02 0.02 0.02 0.03 0.03 0.03 0.03

S.D. 0.002 0.002 0.002 0.003 0.003 0.004 0.002
S.E. 0.000 0.000 0.000 0.001 0.001 0.001 0.000
N 20 22 22 23 23 23 20
NA = NOT APPLICABLE
TABLE A11 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21 1-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23248 0.18 0.22 0.24 0.29 0.30 0.26 0.25
23217 0.15 0.18 0.24 0.28 0.27 0.28 0.24
23190 0.18 0.19 0.26 0.30 0.29 0.33 0.27
23236 NA 0.19 0.24 0.26 0.26 0.28 NA
23260 0.15 0.18 0.22 0.25 0.26 0.28 0.23
23221 0.20 0.22 0.31 0.27 0.34 0.41 0.30
23263 NA 0.22 0.25 0.32 0.30 0.33 NA
23253 0.21 0.21 0.25 0.29 0.31 0.35 0.27
23244 0.19 0.17 0.22 0.24 0.27 0.28 0.23
23218 NA 0.21 0.25 0.35 0.29 0.41 NA
23208 0.19 0.18 0.20 0.30 0.28 0.34 0.25
Page 850 of 4796
23252 0.18 0.20 0.24 0.27 0.30 0.26 0.25

26510 0.17 0.20 0.21 0.26 0.25 0.24 0.23
26519 0.16 0.23 0.26 0.32 0.29 0.32 0.27
26468 0.15 0.19 0.21 0.26 0.25 0.30 0.23
26475 0.17 0.20 0.27 0.29 0.29 0.33 0.27
26532 0.17 0.21 0.25 0.28 0.27 0.31 0.26
26507 0.18 0.19 0.23 0.26 0.27 0.30 0.24
26480 0.20 0.19 0.24 0.26 0.26 0.28 0.24
26482 0.16 0.18 0.22 0.25 0.26 0.31 0.24
26522 NA 0.20 0.24 0.25 0.26 0.30 NA
26517 0.18 0.22 0.25 0.25 0.30 0.29 0.26
26514 0.17 0.20 0.25 0.24 0.28 0.30 0.25
26534 0.21 0.21 0.27 0.26 0.31 0.30 0.27
MEAN 0.18 0.20 0.24 0.28 0.28 0.31 0.25

S.D. 0.020 0.015 0.023 0.027 0.022 0.041 0.019
S.E. 0.004 0.003 0.005 0.006 0.005 0.008 0.004
N 20 24 24 24 24 24 20
NA = NOT APPLICABLE
TABLE A11 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21 1-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23179 8.24 10.39 12.82 13.68 13.51 15.91 12.79
23212 NA 13.73 13.14 13.62 15.20 NA NA
23201 9.60 9.71 11.57 14.94 13.32 14.53 12.56
23259 10.25 11.84 13.97 17.29 17.62 18.61 15.42
23210 10.19 10.36 13.97 14.47 14.91 18.28 14.14
23256 9.26 10.15 12.02 13.58 13.09 15.02 12.50
23238 9.60 9.38 12.21 13.25 14.48 16.57 12.94
23228 9.68 10.34 13.28 14.74 14.56 19.41 14.00
23220 10.48 9.80 12.77 13.68 15.22 16.02 13.34
23183 9.59 12.18 13.25 14.54 16.42 16.40 14.17
Page 851 of 4796
23184 9.41 12.14 12.50 14.56 17.30 15.68 13.95

26497 7.73 10.30 11.68 14.55 13.49 16.97 12.79
26495 9.82 10.82 11.99 15.38 14.41 NA NA
26499 10.07 11.05 14.21 14.96 15.14 17.00 14.15
26494 6.99 8.99 11.08 13.19 12.65 14.39 11.50
26533 10.02 10.52 12.62 13.04 12.84 16.42 12.93
26502 9.42 10.87 12.70 13.09 13.64 16.11 13.00
26451 8.98 9.79 12.13 12.54 13.69 15.55 12.47
26535 9.35 8.88 11.18 11.85 12.52 13.57 11.41
26456 10.17 10.47 11.48 12.88 13.08 14.68 12.31
26518 8.79 11.10 14.01 14.11 15.87 16.35 13.78
26459 7.88 10.57 12.00 12.43 15.38 15.03 12.58
MEAN 9.31 10.61 12.57 13.93 14.47 16.13 13.14

S.D. 0.921 1.121 0.939 1.197 1.453 1.462 0.983
S.E. 0.201 0.239 0.200 0.255 0.310 0.327 0.220
N 21 22 22 22 22 20 20
NA = NOT APPLICABLE
TABLE A11 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21 1-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23198 95.48 119.26 137.50 153.58 152.48 186.07 145.75
23233 61.27 88.74 106.32 126.88 134.42 151.25 115.28
23241 103.62 112.25 119.29 120.47 129.38 165.71 128.44
23254 64.54 SENT TO NECROPSY; SEX RATIO CRITERIA NOT MET
23239 96.79 112.12 123.79 172.86 166.66 198.69 149.12
23245 93.93 106.25 129.05 140.10 150.43 173.98 136.60
23223 101.16 106.69 130.46 168.75 169.67 195.92 149.16
23191 103.94 119.06 141.02 153.98 144.65 163.17 141.77
23247 96.02 103.79 117.98 135.24 153.91 158.35 130.92
23230 81.14 74.77 77.90 134.98 118.33 131.73 104.83
23249 109.14 134.47 100.40 76.09 94.51 91.33 100.63
Page 852 of 4796
23258 91.23 95.94 112.90 103.76 145.89 137.02 116.77

26478 71.93 106.32 123.56 153.54 134.29 183.29 133.85
26501 90.52 84.46 110.80 136.37 128.08 130.97 116.50
26486 73.58 97.58 124.09 139.40 143.48 170.98 128.48
26464 76.16 112.16 130.01 147.66 142.31 158.54 132.35
26498 68.87 92.51 115.69 144.19 130.21 157.52 122.04
26481 71.77 102.38 120.23 129.61 129.13 167.08 124.24
26472 78.85 90.46 98.87 144.18 133.67 143.89 116.99
26537 85.49 100.00 131.53 146.80 148.74 151.88 129.72
26506 62.90 116.00 129.18 160.62 150.71 153.71 132.14
26471 86.84 111.19 135.71 129.12 152.15 150.46 131.61
26455 132.73 NA NA 125.20 139.20 155.06 142.20
MEAN 86.87 104.11 119.82 138.34 140.56 158.03 128.61

S.D. 17.331 13.621 14.993 21.192 16.281 23.691 13.162
S.E. 3.614 2.972 3.272 4.518 3.471 5.051 2.806
N 23 21 21 22 22 22 22
NA = NOT APPLICABLE
TABLE A11 (F0)
-----------------------------------------------------------------------------------------------------------------------------------
DAY 1- 4 4- 7 7-11 11-14 14-17 17-21 1-21

-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23255 267.86 311.40 381.15 422.50 435.17 505.04 399.85
23237 DIED DAY 0
23215 261.76 336.53 406.51 475.20 477.92 567.58 433.80
23214 265.75 355.14 411.48 469.10 505.78 645.41 460.96
23192 271.87 338.20 408.49 423.31 409.10 495.40 405.11
23219 387.92 396.76 427.79 542.30 526.00 669.78 501.44
23211 NA 371.56 360.56 382.66 419.81 527.36 NA
23189 384.14 371.77 384.91 432.70 441.58 537.98 436.30
23204 NA 322.40 465.73 449.01 438.57 532.42 NA
23257 253.80 296.62 349.81 379.57 435.89 453.92 372.15
23234 NA 285.10 372.58 382.14 298.39 607.23 NA
Page 853 of 4796
23227 259.94 328.61 346.30 447.84 488.50 595.28 419.02

26509 221.67 307.51 336.62 415.80 379.39 480.76 368.80
26448 367.65 333.09 364.55 383.11 451.08 505.26 410.56
26508 NA NA NA 485.21 490.68 597.76 NA
26463 299.99 336.96 394.38 437.99 446.56 444.89 401.56
26504 241.56 308.32 334.91 386.93 419.56 470.88 370.39
26465 NA 309.22 384.23 423.43 472.90 534.15 NA
26477 NA 281.75 NA 419.56 461.00 522.13 NA
26511 285.86 296.06 405.20 405.56 444.31 546.62 410.58
26466 297.90 354.58 416.38 425.20 443.61 535.07 423.23
26462 287.80 NA NA 419.20 425.81 425.12 406.01
26523 257.92 303.55 354.78 401.11 385.90 452.90 370.46
26470 278.19 301.63 376.29 392.06 444.76 461.09 387.38
MEAN 287.74 326.04 384.13 426.15 440.97 526.70 410.45

S.D. 48.206 30.768 33.474 39.448 46.944 64.798 34.871
S.E. 11.692 6.714 7.485 8.225 9.789 13.511 8.458
N 17 21 20 23 23 23 17
NA = NOT APPLICABLE
PLFWv4.10
01/12/2009
R:02/05/2009
TABLE A12 (F0)
SPONSOR:ACC INDIVIDUAL GESTATION LENGTHS [DAYS]
-----------------------------------------------------------------------------------------------------------------------------------
GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
GESTATION GESTATION GESTATION GESTATION GESTATION GESTATION
ANIMAL LENGTH ANIMAL LENGTH ANIMAL LENGTH ANIMAL LENGTH ANIMAL LENGTH ANIMAL LENGTH
-----------------------------------------------------------------------------------------------------------------------------------
23243 21. 23195 22. 23248 21. 23179 22. 23198 22. 23255 22.
23213 22. 23180 22. 23217 21. 23212 22. 23233 22. 23237 22.
23203 22. 23176 21. 23190 21. 23201 22. 23241 22. 23215 22.
23207 21. 23251 22. 23236 22. 23259 22. 23254 23. 23214 22.
23226 21. 23235 21. 23260 21. 23210 22. 23239 22. 23192 21.
23242 21. 23231 21. 23221 22. 23256 22. 23245 21. 23219 22.
23209 22. 23216 22. 23263 22. 23238 22. 23223 22. 23211 22.
23178 22. 23261 22. 23253 22. 23228 22. 23191 22. 23189 22.
23186 21. 23205 22. 23244 22. 23246 22. 23247 22. 23204 22.
23194 22. 23181 22. 23218 22. 23220 22. 23230 21. 23257 21.
23182 22. 23264 21. 23208 22. 23183 22. 23249 22. 23234 22.
Page 854 of 4796
23240 22. 26474 22. 23252 22. 23184 22. 23258 22. 23227 21.
26521 22. 26476 22. 26510 22. 26516 22. 26485 21. 26509 22.
26449 22. 26496 22. 26519 21. 26497 22. 26478 22. 26448 22.
26473 22. 26505 22. 26468 22. 26495 22. 26501 22. 26508 22.
26452 22. 26483 22. 26475 22. 26499 22. 26486 22. 26463 22.
26491 22. 26479 22. 26532 21. 26494 21. 26464 22. 26504 21.
26512 22. 26450 22. 26507 21. 26533 22. 26498 21. 26465 22.
26454 22. 26457 21. 26480 22. 26502 22. 26481 22. 26477 22.
26529 22. 26492 21. 26482 22. 26451 22. 26472 21. 26511 22.
26453 22. 26493 22. 26522 22. 26535 22. 26537 22. 26466 22.
26527 21. 26488 22. 26517 22. 26456 22. 26506 21. 26462 22.
26489 22. 26520 22. 26514 22. 26518 22. 26471 22. 26523 21.
26534 22. 26459 22. 26455 22. 26470 22.
-----------------------------------------------------------------------------------------------------------------------------------
MEAN 21.7 21.7 21.7 22.0 21.8 21.8
S.D. 0.45 0.45 0.46 0.20 0.51 0.41
S.E. 0.09 0.09 0.09 0.04 0.10 0.08
N 23 23 24 24 24 24
-----------------------------------------------------------------------------------------------------------------------------------
PGLv5.06
12/16/2008
TABLE A13 (F0 - UNSCHEDULED DEATH)
SPONSOR:ACC INDIVIDUAL ANIMAL CAUSE OF DEATH
BY CAUSE OF DEATH
FEMALES
CAUSE OF DEATH GROUP: 1 2 3 4 5 6
-----------------------------------------------------------------------------------------------------------------------------------
OTHER
UNDETERMINED
- - - - - 23237
-----------------------------------------------------------------------------------------------------------------------------------
# = NEOPLASM, B = BENIGN, M = MALIGNANT, m = ANIMAL HAS MULTIPLE CAUSES OF DEATH
PPCDv4.09
03/26/2009
Page 855 of 4796
TABLE A14 (F0 - UNSCHEDULED DEATH)
SPONSOR:ACC INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGS
ANIMAL NO. 23237 GROUP 6: 2250 PPM FEMALE FOUND DEAD 08/06/08 DATE OF DEATH: 08/06/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
GENERAL COMMENT GROSS: IMPLANTATION SITES (LEFT,RIGHT) P
10,6
GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P
10,6
GENERAL COMMENT GROSS: GRAVID P
UTERUS: LEFT- 3 FETUSES, 7 FORMER IMPLANTATION SITES; RIGHT-
5 FORMER IMPLANTATION SITES, 1 EARLY RESORPTION
OVARIES: CORPORA LUTEA- 10, LEFT; 6, RIGHT
FETAL GROSS OBSERVATIONS
3 DEAD FETUSES, CROWN-RUMP LENGTHS: 4.0 TO 4.4 CM, NO
APPARENT MALFORMATIONS, 3 MALES
SKIN GROSS: MATTING, RED P
BUCCAL; UROGENITAL
Page 856 of 4796
STOMACH GROSS: CONTENTS, DARK RED P

CAUSE OF DEATH MICRO: UNDETERMINED P
NO SIGNIFICANT
CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
HEART INTESTINE KIDNEYS LIVER
LYMPH NODE, MES LUNGS MAMMARY GLAND OVIDUCTS
OVARIES PANCREAS PITUITARY SPINAL CORD
SAL. GLAND MAND SPLEEN THYMUS THYROID GLANDS
TRACHEA URINARY BLADDER UTERUS CERVIX
VAGINA DIAPHRAGM
MICRO:KIDNEYS LIVER
GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT
MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

PGRHv4.63
03/26/2009
TABLE A15 (F0 - FAILED TO DELIVER)
ANIMAL NO. 26528 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 09/07/08 DATE OF DEATH: 09/07/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: NONGRAVID- AMMONIUM SULFIDE NEGATIVE P
LIVER 9.81 3.554 LIVER MICRO: INFILTRATE, MONONUCLEAR 1
KIDNEYS 1.86 0.674 UTERUS GROSS: CONTENTS, CLEAR FLUID P
FINAL BODY WT(G) 276. BOTH HORNS
NO SIGNIFICANT
SAL. GLAND MAND SKIN SPLEEN STOMACH
THYMUS THYROID GLANDS TRACHEA URINARY BLADDER
CERVIX VAGINA DIAPHRAGM
MICRO:KIDNEYS
Page 857 of 4796

TABLE A15 (F0 - FAILED TO DELIVER)
ANIMAL NO. 23199 GROUP 2: 0.15 PPM FEMALE SCHEDULED EUTH 08/10/08 DATE OF DEATH: 08/10/08
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) GENERAL COMMENT GROSS: NONGRAVID- AMMONIUM SULFIDE NEGATIVE P
LIVER 10.01 KIDNEYS MICRO: MINERALIZATION 1
KIDNEYS 2.10 AT CORTICOMEDULLARY JUNCTION
NO SIGNIFICANT
UTERUS CERVIX VAGINA DIAPHRAGM
MICRO:LIVER
Page 858 of 4796

PGRHv4.63
03/26/2009
TABLE A16 (F0 - PUP SEX RATIO CRITERIA NOT MET)
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: FORMER IMPLANTATION SITES (LEFT,RIGHT) P
LIVER 13.21 4.128 14,3
KIDNEYS 2.46 0.769 GENERAL COMMENT GROSS: CORPORA LUTEA (LEFT,RIGHT) P
FINAL BODY WT(G) 320. 16,5
NO SIGNIFICANT
MICRO:KIDNEYS LIVER
Page 859 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 12.07 4.220 6,9
KIDNEYS MICRO: CYST P
CORTEX; UNILATERAL
LIVER MICRO: HEMATOPOIESIS, EXTRAMEDULLARY 2
INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
Page 860 of 4796


GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 10.50 4.070 8,9
KIDNEYS MICRO: MINERALIZATION 1
AT CORTICOMEDULLARY JUNCTION
MINERALIZATION, PAPILLARY TUBULAR 1
NO SIGNIFICANT
Page 861 of 4796

MICRO:LIVER

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.33 3.898 6,10
LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
Page 862 of 4796


PGRHv4.63
03/26/2009
TABLE A17 (F0 - LACTATION DAY 21)
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.88 5.051 7,8
KIDNEYS 2.65 0.749 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
FINAL BODY WT(G) 354. LIVER MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
Page 863 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 18.36 5.368 8,8
NO SIGNIFICANT
Page 864 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.36 4.989 9,8
KIDNEYS 2.55 0.733 LIVER MICRO: INFILTRATE, MONONUCLEAR 2
FINAL BODY WT(G) 348. NECROSIS 2
MULTIFOCAL
NO SIGNIFICANT
Page 865 of 4796
MICRO:KIDNEYS

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.36 5.408 5,10
KIDNEYS 2.62 0.816 KIDNEYS MICRO: MINERALIZATION 2
FINAL BODY WT(G) 321. AT CORTICOMEDULLARY JUNCTION
NO SIGNIFICANT
Page 866 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.72 5.555 7,8
KIDNEYS 2.72 0.853 NO SIGNIFICANT
FINAL BODY WT(G) 319. CHANGES OBSERVED GROSS:ADRENAL GLANDS BRAIN ESOPHAGUS EYES
MICRO:KIDNEYS LIVER

Page 867 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 19.81 5.644 6,12
NO SIGNIFICANT
Page 868 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 16.24 4.819 6,12
FINAL BODY WT(G) 337. NO SIGNIFICANT
MICRO:KIDNEYS
Page 869 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.54 4.690 5,12
NO SIGNIFICANT
Page 870 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 18.14 5.011 9,6
MICRO:KIDNEYS
Page 871 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.68 4.380 8,9
FINAL BODY WT(G) 358. MINERALIZATION 1
NO SIGNIFICANT
Page 872 of 4796
MICRO:LIVER

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.93 4.436 7,9
MICRO:KIDNEYS
Page 873 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.47 4.729 8,8
FINAL BODY WT(G) 306. STOMACH GROSS: CONTENTS, YELLOW P
NO SIGNIFICANT
SAL. GLAND MAND SKIN SPLEEN THYMUS
THYROID GLANDS TRACHEA URINARY BLADDER UTERUS
MICRO:KIDNEYS
Page 874 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.33 4.646 10,8
KIDNEYS 2.55 0.684 KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
Page 875 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.48 4.401 8,9
NO SIGNIFICANT
Page 876 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 16.04 4.531 6,9
NO SIGNIFICANT
Page 877 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.11 4.034 9,8
MICRO:KIDNEYS
Page 878 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.56 4.282 7,7
NO SIGNIFICANT
Page 879 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.67 4.609 6,8
NO SIGNIFICANT
Page 880 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.39 4.220 11,5
MICRO:LIVER
Page 881 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 18.28 5.064 8,9
NO SIGNIFICANT
Page 882 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.43 4.286 8,10
NO SIGNIFICANT
Page 883 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.01 4.313 10,7
NO SIGNIFICANT
Page 884 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 11.90 3.940 8,11
MICRO:KIDNEYS
Page 885 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.62 5.137 6,8
KIDNEYS 2.68 0.781 KIDNEYS GROSS: PALE P
FINAL BODY WT(G) 343. BILATERAL
KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
NO CORRELATE TO GROSS PALLOR
NO SIGNIFICANT
HEART INTESTINE LIVER LYMPH NODE, MES
LUNGS MAMMARY GLAND OVIDUCTS OVARIES
PANCREAS PITUITARY SPINAL CORD SAL. GLAND MAND
SKIN SPLEEN STOMACH THYMUS
Page 886 of 4796


GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 16.74 4.797 8,9
MICRO:KIDNEYS
Page 887 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 16.78 4.794 9,7
KIDNEYS 2.77 0.791 KIDNEYS GROSS: AREA(S), DEPRESSED P
FINAL BODY WT(G) 350. FEW, PINPOINT, IN CORTEX, BILATERAL
CORRELATES WITH GROSS DEPRESSED AREA(S)
MINERALIZATION 1
NO SIGNIFICANT
Page 888 of 4796


GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 19.92 5.518 8,7
NO SIGNIFICANT
Page 889 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.12 5.050 7,8
NO SIGNIFICANT
Page 890 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 19.28 5.621 8,6
KIDNEYS 2.69 0.784 KIDNEYS MICRO: BASOPHILIC TUBULES 1
NO SIGNIFICANT
Page 891 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 16.08 4.647 7,11
KIDNEYS 2.73 0.789 KIDNEYS MICRO: MINERALIZATION, PAPILLARY TUBULAR 1
NO SIGNIFICANT
Page 892 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.07 4.394 7,8
NO SIGNIFICANT
Page 893 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 20.72 5.382 10,8
MICRO:KIDNEYS
Page 894 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.65 4.334 6,11
NO SIGNIFICANT
Page 895 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.58 3.962 6,8
MICRO:KIDNEYS
Page 896 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.37 4.055 8,12
MICRO:KIDNEYS
Page 897 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.74 4.248 5,12
MICRO:KIDNEYS
Page 898 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.91 4.505 8,6
NO SIGNIFICANT
Page 899 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.12 4.370 6,6
FINAL BODY WT(G) 346. FEW, PINPOINT TO 1 MM IN DIAMETER, IN CORTEX, BILATERAL
NO CORRELATE TO GROSS DEPRESSED AREA(S)
MINERALIZATION 1
NO SIGNIFICANT
Page 900 of 4796


GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.14 4.405 7,9
MICRO:KIDNEYS
Page 901 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.84 4.339 7,8
NO SIGNIFICANT
Page 902 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.59 4.254 10,9
NO SIGNIFICANT
MICRO:LIVER
Page 903 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.90 4.556 10,9
NO SIGNIFICANT
Page 904 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.77 4.232 7,10
NO SIGNIFICANT
Page 905 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.01 4.712 11,10
NO SIGNIFICANT
Page 906 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.40 4.557 4,11
MICRO:KIDNEYS
Page 907 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 16.04 4.997 6,10
NO SIGNIFICANT
Page 908 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 20.24 5.271 7,10
FINAL BODY WT(G) 384. ONE, 3 X 1 X 1 MM, IN CORTEX, LEFT; ONE, PINPOINT, IN
CORTEX, RIGHT
NO SIGNIFICANT
Page 909 of 4796


GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.69 4.668 11,10
NO SIGNIFICANT
Page 910 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 16.96 5.003 6,11
NO SIGNIFICANT
Page 911 of 4796
MICRO:LIVER

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 18.02 5.347 8,7
MICRO:KIDNEYS
Page 912 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.04 4.800 8,6
MICRO:KIDNEYS
Page 913 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.47 4.594 6,9
FINAL BODY WT(G) 315. INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
Page 914 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.11 4.202 7,8
NO SIGNIFICANT
Page 915 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 16.88 4.865 5,12
NO SIGNIFICANT
Page 916 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 16.66 4.602 11,7
NO SIGNIFICANT
MICRO:LIVER
Page 917 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.36 4.339 12,6
NO SIGNIFICANT
Page 918 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 18.27 4.614 5,10
NO SIGNIFICANT
Page 919 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 16.85 4.720 10,7
NO SIGNIFICANT
Page 920 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 18.76 5.453 5,11
HYPERPLASIA, BILE DUCT 1
NECROSIS 1
FOCAL
SPLEEN GROSS: NODULE(S) P
MULTIPLE, 1 TO 3 MM IN DIAMETER
SPLEEN GROSS: AREA(S), WHITE P
FEW, IRREGULARLY SHAPED
NO SIGNIFICANT
Page 921 of 4796

SAL. GLAND MAND SKIN STOMACH THYMUS

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.74 4.285 10,8
NO SIGNIFICANT
Page 922 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.06 4.210 8,7
MICRO:KIDNEYS
Page 923 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.48 4.511 11,3
NO SIGNIFICANT
Page 924 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.64 4.561 7,10
KIDNEYS 2.47 0.769 KIDNEYS MICRO: DILATATION, TUBULAR 1
FINAL BODY WT(G) 321. MEDULLA; UNILATERAL
NO SIGNIFICANT
Page 925 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.45 4.465 10,10
NO SIGNIFICANT
Page 926 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 18.26 5.115 11,7
FINAL BODY WT(G) 357. INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
Page 927 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.37 4.139 9,4
MICRO:KIDNEYS
Page 928 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.86 3.872 9,6
NO SIGNIFICANT
Page 929 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.38 3.901 6,11
MICRO:KIDNEYS
Page 930 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.90 4.730 10,7
NO SIGNIFICANT
Page 931 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.60 4.756 5,11
NO SIGNIFICANT
Page 932 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.32 5.170 7,3
KIDNEYS 2.86 0.854 KIDNEYS GROSS: PALE P
FINAL BODY WT(G) 335. BILATERAL
KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
NO CORRELATE TO GROSS PALLOR
NO SIGNIFICANT
Page 933 of 4796


GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.30 5.044 11,7
NO SIGNIFICANT
Page 934 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.99 5.170 6,9
FINAL BODY WT(G) 348. FEW, PINPOINT, IN CORTEX, RIGHT
NO SIGNIFICANT
Page 935 of 4796


GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.86 4.748 5,9
NO SIGNIFICANT
Page 936 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.45 4.676 8,9
THYMUS GROSS: AREA(S), DARK RED P
MULTIPLE, PINPOINT
^==> THYMUS: HEMORRHAGE
THYMUS MICRO: HEMORRHAGE 1
NO SIGNIFICANT
Page 937 of 4796


^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.07 4.138 10,6
NO SIGNIFICANT
Page 938 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.30 4.181 8,11
#M NEPHROBLASTOMA P
UNILATERAL
NO SIGNIFICANT
Page 939 of 4796


# = NEOPLASM, M = MALIGNANT
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.38 4.387 9,9
MICRO:KIDNEYS
Page 940 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.36 4.863 7,11
NO SIGNIFICANT
Page 941 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.79 4.960 4,9
MICRO:KIDNEYS
Page 942 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.88 4.870 8,10
KIDNEYS 2.48 0.870 KIDNEYS MICRO: MINERALIZATION, PAPILLARY TUBULAR 1
FINAL BODY WT(G) 285. STOMACH GROSS: AREA(S), DARK RED P
MULTIPLE, IRREGULARLY SHAPED, GLANDULAR PORTION
^==> STOMACH: EROSION
STOMACH MICRO: EROSION 1
FOCAL; GLANDULAR STOMACH
NO SIGNIFICANT
Page 943 of 4796

MICRO:LIVER

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.33 4.469 4,12
MICRO:KIDNEYS
Page 944 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.55 4.396 6,9
NO SIGNIFICANT
Page 945 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.46 4.786 7,10
NO SIGNIFICANT
Page 946 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.24 4.302 4,8
NO SIGNIFICANT
Page 947 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.95 4.387 10,6
NO SIGNIFICANT
Page 948 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.08 4.346 11,7
MICRO:KIDNEYS
Page 949 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.15 4.417 5,12
NO SIGNIFICANT
Page 950 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.59 4.274 7,11
FINAL BODY WT(G) 318. MULTIPLE, PINPOINT, IN CORTEX, RIGHT
KIDNEYS MICRO: INFILTRATE, MONONUCLEAR 1
NO SIGNIFICANT
Page 951 of 4796


GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.03 4.126 8,11
MICRO:KIDNEYS
Page 952 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.81 4.329 6,7
THYMUS GROSS: AREA(S), DARK RED P
MULTIPLE, 1 MM IN DIAMETER
NO SIGNIFICANT
Page 953 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.35 4.362 3,11
FINAL BODY WT(G) 329. STOMACH GROSS: AREA(S), DARK RED P
FEW, PINPOINT TO 1 MM IN DIAMETER, NONGLANDULAR PORTION
NO SIGNIFICANT
Page 954 of 4796
MICRO:KIDNEYS

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 16.95 5.313 10,5
FINAL BODY WT(G) 319. ONE, PINPOINT, IN CORTEX, LEFT
KIDNEYS GROSS: PALE P
BILATERAL
KIDNEYS MICRO: NO SIGNIFICANT CHANGES OBSERVED
NO CORRELATES TO GROSS PALLOR OR DEPRESSED AREA(S)
NO SIGNIFICANT
Page 955 of 4796

MICRO:KIDNEYS

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.69 4.432 7,6
NO SIGNIFICANT
Page 956 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.35 5.014 8,7
MICRO:KIDNEYS
Page 957 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.17 4.977 7,7
NO SIGNIFICANT
Page 958 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.45 5.133 9,8
MICRO:KIDNEYS
Page 959 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 16.22 4.595 9,8
NO SIGNIFICANT
Page 960 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 18.21 5.603 6,10
NO SIGNIFICANT
Page 961 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.41 4.129 11,7
MICRO:KIDNEYS
Page 962 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 18.18 5.022 7,9
MICRO:KIDNEYS
Page 963 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 12.91 3.912 6,10
FINAL BODY WT(G) 330. MINERALIZATION, PAPILLARY TUBULAR 1
CYST P
MEDULLA; UNILATERAL
NO SIGNIFICANT
Page 964 of 4796


GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 12.01 3.837 4,8
NO SIGNIFICANT
Page 965 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.71 4.056 9,4
NO SIGNIFICANT
Page 966 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.88 4.769 7,10
NO SIGNIFICANT
Page 967 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 12.47 4.375 6,9
HEMATOPOIESIS, EXTRAMEDULLARY 1
NO SIGNIFICANT
Page 968 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.44 4.336 7,6
KIDNEYS 2.52 0.757 KIDNEYS MICRO: BASOPHILIC TUBULES 1
NO SIGNIFICANT
Page 969 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.20 4.201 7,12
FINAL BODY WT(G) 338. HEMATOPOIESIS, EXTRAMEDULLARY 1
NO SIGNIFICANT
MICRO:KIDNEYS
Page 970 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
ORGAN WEIGHT ABS.(G) REL. KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1
LIVER 16.72 4.710 LIVER MICRO: INFILTRATE, MONONUCLEAR 1

Page 971 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.15 4.262 8,10
MICRO:KIDNEYS
Page 972 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.36 4.327 10,8
NECROSIS 1
FOCAL
NO SIGNIFICANT
Page 973 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.04 4.398 6,11
NO SIGNIFICANT
Page 974 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.64 4.618 6,9
NO SIGNIFICANT
Page 975 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 12.92 4.336 9,6
MICRO:KIDNEYS
Page 976 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.73 4.960 8,8
KIDNEYS 2.30 0.774 SKIN GROSS: HAIR LOSS P
FINAL BODY WT(G) 297. ALL EXTERNAL SURFACES
NO SIGNIFICANT
SAL. GLAND MAND SPLEEN STOMACH THYMUS
MICRO:KIDNEYS LIVER
Page 977 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.62 5.356 9,8
NO SIGNIFICANT
MICRO:LIVER
Page 978 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 17.23 5.318 5,9
MICRO:KIDNEYS
Page 979 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.58 4.867 8,7
FINAL BODY WT(G) 279. ONE, IRREGULARLY SHAPED, IN CORTEX, RIGHT
NO SIGNIFICANT
Page 980 of 4796

MICRO:LIVER

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.60 4.479 7,9
MICRO:KIDNEYS
Page 981 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.08 4.319 9,5
NO SIGNIFICANT
MICRO:LIVER
Page 982 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.51 4.235 11,7
KIDNEYS 2.50 0.784 KIDNEYS MICRO: CYST P
FINAL BODY WT(G) 319. MEDULLA; UNILATERAL
NO SIGNIFICANT
Page 983 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.48 4.611 8,10
MICRO:KIDNEYS LIVER

Page 984 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 18.94 5.037 9,9
NO SIGNIFICANT
Page 985 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.76 3.977 12,4
KIDNEYS 2.77 0.801 KIDNEYS GROSS: DILATED PELVIS 2
FINAL BODY WT(G) 346. RIGHT
^==> KIDNEYS: HYDRONEPHROSIS
KIDNEYS MICRO: BASOPHILIC TUBULES 3
IN HYDRONEPHROTIC KIDNEY
HYDRONEPHROSIS 2
UNILATERAL
LIVER GROSS: DISCOLORATION, DARK RED P
CAUDATE LOBE
^==> LIVER: HEMORRHAGE
^==> LIVER: PIGMENT, BROWN
Page 986 of 4796

HEMORRHAGE 2
CAUDATE LOBE
PIGMENT, BROWN 2
CAUDATE LOBE
FIBROSIS 2
CAUDATE LOBE
DIAPHRAGM GROSS: HERNIA P
PORTION OF CAUDATE LOBE OF LIVER PROTRUDES INTO THORACIC
CAVITY THROUGH AN OPENING IN THE DIAPHRAGM
^==> DIAPHRAGM: FIBROSIS
DIAPHRAGM MICRO: FIBROSIS 2
CONSISTENT WITH GROSS HERNIA
GRADE
-----------------------------------------------------------------------------------------------------------------------------------
URETERS GROSS: DISTENDED 1
BILATERAL
^==> URETERS: DILATATION, LUMEN
URETERS MICRO: DILATATION, LUMEN 2
NO SIGNIFICANT
HEART INTESTINE LYMPH NODE, MES LUNGS
MAMMARY GLAND OVIDUCTS OVARIES PANCREAS
PITUITARY SPINAL CORD SAL. GLAND MAND SKIN
SPLEEN STOMACH THYMUS THYROID GLANDS
VAGINA
Page 987 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.17 4.347 7,9
NO SIGNIFICANT
Page 988 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.20 4.343 8,8
FINAL BODY WT(G) 350. AT CORTICOMEDULLARY JUNCTION AND IN URINARY SPACE
NO SIGNIFICANT
Page 989 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 16.26 4.418 7,8
NO SIGNIFICANT
Page 990 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.56 4.245 9,7
NO SIGNIFICANT
Page 991 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 12.88 3.963 7,8
MICRO:KIDNEYS
Page 992 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.56 4.439 8,8
NO SIGNIFICANT
Page 993 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.18 4.727 4,12
MICRO:KIDNEYS
Page 994 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 13.43 4.107 7,7
KIDNEYS 2.34 0.716 KIDNEYS GROSS: DILATED PELVIS 3
FINAL BODY WT(G) 327. RIGHT
^==> KIDNEYS: HYDRONEPHROSIS
HYDRONEPHROSIS 2
UNILATERAL
NO SIGNIFICANT
Page 995 of 4796


GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.71 4.326 6,8
NO SIGNIFICANT
Page 996 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.77 4.294 11,7
NO SIGNIFICANT
Page 997 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.62 4.567 9,9
KIDNEYS 2.64 0.772 KIDNEYS MICRO: DILATATION, TUBULAR 1
FINAL BODY WT(G) 342. CORTEX; FOCAL
NO SIGNIFICANT
Page 998 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 14.69 4.258 7,12
MICRO:KIDNEYS
Page 999 of 4796

GRADE
-----------------------------------------------------------------------------------------------------------------------------------
LIVER 15.33 5.026 9,9
MINERALIZATION, PAPILLARY TUBULAR 1
UNILATERAL
LUNGS GROSS: AREA(S), DARK RED P
MULTIPLE, IRREGULARLY SHAPED, ALL LOBES
SKIN GROSS: MATTING, RED P
NASAL
NO SIGNIFICANT
Page 1000 of 4796

LYMPH NODE, MES MAMMARY GLAND OVIDUCTS OVARIES
SPLEEN STOMACH THYMUS THYROID GLANDS
VAGINA DIAPHRAGM

PGRHv4.63
08/18/2009
FINAL REPORT
Volume 4 of 16
STUDY TITLE
STUDY NUMBER
WIL-186056
DATA REQUIREMENT

OECD Guideline 426
STUDY DIRECTOR
26 June 2008
30 September 2009

1407 George Road
SPONSOR

Arlington, VA 22209
Page 1001 of 4796

APPENDIX A
TABLES A18-A24
Page 1002 of 4796

TABLE A18 (F0)
SPONSOR:ACC INDIVIDUAL IMPLANTATION SITES
0 PPM
DAM IMPLANTATION PUPS UNACCOUNTED
NO. SITES BORN SITES
-----------------------------------------------------------------------------------------------------------------------------------
23243 15 15 0
23213 16 15 1
23203 17 17 0
23207 15 14 1
23226 15 15 0
23242 18 17 1
23209 18 16 2
23178 17 15 2
23186 15 14 1
23194 17 17 0
23182 16 16 0
23240 16 15 1
26521 18 17 1
Page 1003 of 4796
26449 17 17 0
26473 15 15 0
26452 17 17 0
26491 14 14 0
26512 14 13 1
26454 16 15 1
26529 17 16 1
26453 18 17 1
26527 17 14 3
26489 19-A 20 A
-----------------------------------------------------------------------------------------------------------------------------------
MEAN 16.3 15.7 0.8
S.D. 1.28 1.55 0.81
S.E. 0.27 0.32 0.17
N 22 23 22
A = NUMBER OF PUPS BORN EXCEEDED NUMBER OF IMPLANTATION SITES; VALUE NOT INCLUDED IN CALCULATION OF MEAN
TABLE A18 (F0)
0.15 PPM
-----------------------------------------------------------------------------------------------------------------------------------
23195 14 12 2
23180 17 16 1
23176 16 16 0
23251 15 15 0
23235 15 15 0
23231 14 13 1
23216 18 17 1
23261 15 13 2
23205 18 16 2
23181 17 14 3
23264 14 14 0
26474 20 17 3
26476 17 16 1
Page 1004 of 4796
26496 14 12 2
26505 12 12 0
26483 16 14 2
26479 15 14 1
26450 19 18 1
26457 19 17 2
26492 17 17 0
26493 21 21 0
26488 15 14 1
26520 16 16 0
-----------------------------------------------------------------------------------------------------------------------------------
MEAN 16.3 15.2 1.1
S.D. 2.20 2.19 1.00
S.E. 0.46 0.46 0.21
N 23 23 23
TABLE A18 (F0)
1.5 PPM
-----------------------------------------------------------------------------------------------------------------------------------
23248 17 17 0
23217 21 21 0
23190 17 17 0
23236 15-A 16 A
23260 14 14 0
23221 15 14 1
23263 15 15 0
23253 17 17 0
23244 18 17 1
23218 18 17 1
23208 15 14 1
23252 17 17 0
26510 16 15 1
Page 1005 of 4796
26519 18 15 3
26468 15 13 2
26475 14 14 0
26532 17 16 1
26507 20 18 2
26480 18 18 0
26482 13 13 0
26522 15 14 1
26517 17 16 1
26514 17 16 1
26534 16 16 0
-----------------------------------------------------------------------------------------------------------------------------------
MEAN 16.5 15.8 0.7
S.D. 1.90 1.86 0.82
S.E. 0.40 0.38 0.17
N 23 24 23
A = NUMBER OF PUPS BORN EXCEEDED NUMBER OF IMPLANTATION SITES; VALUE NOT INCLUDED IN CALCULATION OF MEAN
TABLE A18 (F0)
75 PPM
-----------------------------------------------------------------------------------------------------------------------------------
23179 10 10 0
23212 18 18 0
23201 15 14 1
23259 14 13 1
23210 17 16 1
23256 16 16 0
23238 19 19 0
23228 18 16 2
23246 17 7 10
23220 18 18 0
23183 13 12 1
23184 18 16 2
26516 15 15 0
Page 1006 of 4796
26497 16 16 0
26495 15 14 1
26499 17 17 0
26494 12 12 0
26533 16 15 1
26502 18 17 1
26451 17 17 0
26535 18 17 1
26456 19 18 1
26518 13 12 1
26459 14 13 1
-----------------------------------------------------------------------------------------------------------------------------------
MEAN 16.0 14.9 1.0
S.D. 2.35 2.87 2.01
S.E. 0.48 0.59 0.41
N 24 24 24
TABLE A18 (F0)
750 PPM
-----------------------------------------------------------------------------------------------------------------------------------
23198 15 15 0
23233 13 12 1
23241 15 13 2
23254 17 11 6
23239 14 13 1
23245 17 14 3
23223 17 16 1
23191 16 16 0
23247 18 16 2
23230 16 16 0
23249 16 13 3
23258 12 12 0
26485 16 14 2
Page 1007 of 4796
26478 13 12 1
26501 17 17 0
26486 15 14 1
26464 13 13 0
26498 19 16 3
26472 18 18 0
26537 18 16 2
26506 17 17 0
26471 15 14 1
26455 15 14 1
-----------------------------------------------------------------------------------------------------------------------------------
MEAN 15.7 14.4 1.3
S.D. 1.86 1.90 1.46
S.E. 0.39 0.40 0.30
N 23 23 23
TABLE A18 (F0)
2250 PPM
-----------------------------------------------------------------------------------------------------------------------------------
23255 16 16 0
23237 16 12 4-B
23215 17 16 1
23214 14 14 0
23192 15 13 2
23219 16 16 0
23211 14 14 0
23189 18 18 0
23204 18 18 0
23257 18 17 1
23234 16 15 1
23227 16 16 0
26509 16 13 3
Page 1008 of 4796
26448 15 15 0
26508 16 16 0
26463 15 15 0
26504 16 14 2
26465 16 15 1
26477 14 13 1
26511 14 14 0
26466 18 17 1
26462 18 17 1
26523 19 17 2
26470 18 17 1
-----------------------------------------------------------------------------------------------------------------------------------
MEAN 16.2 15.3 0.7
S.D. 1.50 1.69 0.86
S.E. 0.31 0.34 0.18
N 24 24 23
B = FEMALE WAS FOUND DEAD ON LACTATION DAY 0 WITH 3 FETUSES AND 1 EARLY RESORPTION RETAINED IN UTERO; NOT INCLUDED IN
CALCULATION OF MEAN
PIISv4.09
12/17/2008
R:02/05/2009
SPONSOR:ACC INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G]
FEMALE GROUP: 0 PPM

-----------------------------------------------------------------------------------------------------------------------------------
ANIMAL FBW(G) LIVER KIDNEYS

-----------------------------------------------------------------------------------------------------------------------------------
23243 354. 17.88 2.65
23213 342. 18.36 2.67
23203 348. 17.36 2.55
23207 321. 17.36 2.62
23226 319. 17.72 2.72
23242 351. 19.81 2.73
23209 337. 16.24 2.70
23178 310. 14.54 2.40
23186 362. 18.14 2.73
23194 358. 15.68 2.90
23182 314. 13.93 2.63
23240 306. 14.47 2.63
Page 1009 of 4796
26521 373. 17.33 2.55

26449 329. 14.48 2.54
26473 354. 16.04 2.60
26452 325. 13.11 2.35
26491 340. 14.56 2.49
26512 340. 15.67 2.41
26454 341. 14.39 2.38
26529 361. 18.28 3.23
26453 360. 15.43 2.81
26527 348. 15.01 2.42
26489 302. 11.90 2.20
MEAN 339. 15.99 2.60

S.D. 19.9 1.957 0.213
S.E. 4.1 0.408 0.044
N 23 23 23
FBW = FINAL BODY WEIGHT

FEMALE GROUP: 0.15 PPM

-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
23195 343. 17.62 2.68
23180 349. 16.74 3.05
23176 350. 16.78 2.77
23251 361. 19.92 2.90
23235 339. 17.12 2.40
23231 343. 19.28 2.69
23216 346. 16.08 2.73
23261 343. 15.07 2.70
23205 385. 20.72 3.20
23181 338. 14.65 2.93
23264 368. 14.58 2.53
26474 379. 15.37 2.80
Page 1010 of 4796
26476 347. 14.74 2.43

26496 331. 14.91 2.50
26505 346. 15.12 2.52
26483 321. 14.14 2.40
26479 319. 13.84 2.53
26450 343. 14.59 2.24
26457 349. 15.90 3.06
26492 349. 14.77 2.47
26493 361. 17.01 2.99
26488 316. 14.40 2.59
26520 321. 16.04 2.51
MEAN 346. 16.06 2.68

S.D. 17.6 1.874 0.251
S.E. 3.7 0.391 0.052
N 23 23 23


-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
23248 384. 20.24 3.31
23217 379. 17.69 2.74
23190 339. 16.96 2.63
23236 337. 18.02 2.41
23260 355. 17.04 2.89
23221 315. 14.47 2.58
23263 312. 13.11 2.18
23253 347. 16.88 2.75
23244 362. 16.66 2.71
23218 354. 15.36 3.10
23208 396. 18.27 3.06
23252 357. 16.85 2.73
Page 1011 of 4796
26510 344. 18.76 2.98

26519 344. 14.74 2.57
26468 334. 14.06 2.28
26475 321. 14.48 2.66
26532 321. 14.64 2.47
26507 346. 15.45 2.96
26480 357. 18.26 2.38
26482 323. 13.37 2.38
26522 358. 13.86 2.37
26517 343. 13.38 2.50
26514 315. 14.90 2.42
26534 307. 14.60 2.61
MEAN 344. 15.92 2.65

S.D. 23.2 1.967 0.284
S.E. 4.7 0.402 0.058
N 24 24 24

FEMALE GROUP: 75 PPM

-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
23179 335. 17.32 2.86
23212 343. 17.30 2.81
23201 348. 17.99 2.72
23259 313. 14.86 2.35
23210 309. 14.45 2.78
23256 340. 14.07 2.59
23238 342. 14.30 3.39
23228 305. 13.38 2.64
23220 357. 17.36 2.67
23183 278. 13.79 2.44
23184 285. 13.88 2.48
26497 343. 15.33 2.45
Page 1012 of 4796
26495 331. 14.55 2.48

26499 323. 15.46 2.70
26494 331. 14.24 2.05
26533 318. 13.95 2.36
26502 347. 15.08 2.69
26451 343. 15.15 2.34
26535 318. 13.59 2.25
26456 340. 14.03 2.35
26518 319. 13.81 2.72
26459 329. 14.35 2.54
MEAN 327. 14.92 2.58

S.D. 20.2 1.364 0.273
S.E. 4.3 0.291 0.058
N 22 22 22


-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
23198 319. 16.95 2.35
23233 354. 15.69 2.62
23241 346. 17.35 2.70
23239 345. 17.17 2.73
23245 301. 15.45 2.64
23223 353. 16.22 2.97
23191 325. 18.21 2.29
23247 349. 14.41 2.76
23230 362. 18.18 3.01
23249 330. 12.91 2.47
23258 313. 12.01 2.09
26478 338. 13.71 2.41
Page 1013 of 4796
26501 312. 14.88 2.44

26486 285. 12.47 2.24
26464 333. 14.44 2.52
26498 338. 14.20 2.64
26481 355. 16.72 2.53
26472 332. 14.15 2.46
26537 355. 15.36 2.91
26506 342. 15.04 2.46
26471 317. 14.64 2.36
26455 298. 12.92 2.12
MEAN 332. 15.14 2.53

S.D. 21.0 1.788 0.251
S.E. 4.5 0.381 0.054
N 22 22 22


-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
23255 297. 14.73 2.30
23215 329. 17.62 2.46
23214 324. 17.23 2.54
23192 279. 13.58 2.39
23219 326. 14.60 2.34
23211 326. 14.08 2.55
23189 319. 13.51 2.50
23204 314. 14.48 2.42
23257 376. 18.94 2.68
23234 346. 13.76 2.77
23227 349. 15.17 3.02
26509 350. 15.20 2.63
Page 1014 of 4796
26448 368. 16.26 2.74

26508 343. 14.56 2.77
26463 325. 12.88 2.44
26504 328. 14.56 2.51
26465 300. 14.18 2.35
26477 327. 13.43 2.34
26511 340. 14.71 2.39
26466 344. 14.77 2.53
26462 342. 15.62 2.64
26523 345. 14.69 2.38
26470 305. 15.33 2.18
MEAN 331. 14.95 2.52

S.D. 22.5 1.428 0.192
S.E. 4.7 0.298 0.040
N 23 23 23
POFBWv4.14
12/17/2008
R:01/12/2009
SPONSOR:ACC INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G]
FEMALE GROUP: 0 PPM

-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
23243 354. 5.051 0.749
23213 342. 5.368 0.781
23203 348. 4.989 0.733
23207 321. 5.408 0.816
23226 319. 5.555 0.853
23242 351. 5.644 0.778
23209 337. 4.819 0.801
23178 310. 4.690 0.774
23186 362. 5.011 0.754
23194 358. 4.380 0.810
23182 314. 4.436 0.838
23240 306. 4.729 0.859
Page 1015 of 4796
26521 373. 4.646 0.684

26449 329. 4.401 0.772
26473 354. 4.531 0.734
26452 325. 4.034 0.723
26491 340. 4.282 0.732
26512 340. 4.609 0.709
26454 341. 4.220 0.698
26529 361. 5.064 0.895
26453 360. 4.286 0.781
26527 348. 4.313 0.695
26489 302. 3.940 0.728
MEAN 339. 4.713 0.769

S.D. 19.9 0.4798 0.0567
S.E. 4.1 0.1001 0.0118
N 23 23 23


-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
23195 343. 5.137 0.781
23180 349. 4.797 0.874
23176 350. 4.794 0.791
23251 361. 5.518 0.803
23235 339. 5.050 0.708
23231 343. 5.621 0.784
23216 346. 4.647 0.789
23261 343. 4.394 0.787
23205 385. 5.382 0.831
23181 338. 4.334 0.867
23264 368. 3.962 0.688
26474 379. 4.055 0.739
Page 1016 of 4796
26476 347. 4.248 0.700

26496 331. 4.505 0.755
26505 346. 4.370 0.728
26483 321. 4.405 0.748
26479 319. 4.339 0.793
26450 343. 4.254 0.653
26457 349. 4.556 0.877
26492 349. 4.232 0.708
26493 361. 4.712 0.828
26488 316. 4.557 0.820
26520 321. 4.997 0.782
MEAN 346. 4.646 0.775

S.D. 17.6 0.4550 0.0604
S.E. 3.7 0.0949 0.0126
N 23 23 23


-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
23248 384. 5.271 0.862
23217 379. 4.668 0.723
23190 339. 5.003 0.776
23236 337. 5.347 0.715
23260 355. 4.800 0.814
23221 315. 4.594 0.819
23263 312. 4.202 0.699
23253 347. 4.865 0.793
23244 362. 4.602 0.749
23218 354. 4.339 0.876
23208 396. 4.614 0.773
23252 357. 4.720 0.765
Page 1017 of 4796
26510 344. 5.453 0.866

26519 344. 4.285 0.747
26468 334. 4.210 0.683
26475 321. 4.511 0.829
26532 321. 4.561 0.769
26507 346. 4.465 0.855
26480 357. 5.115 0.667
26482 323. 4.139 0.737
26522 358. 3.872 0.662
26517 343. 3.901 0.729
26514 315. 4.730 0.768
26534 307. 4.756 0.850
MEAN 344. 4.626 0.772

S.D. 23.2 0.4199 0.0642
S.E. 4.7 0.0857 0.0131
N 24 24 24


-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
23179 335. 5.170 0.854
23212 343. 5.044 0.819
23201 348. 5.170 0.782
23259 313. 4.748 0.751
23210 309. 4.676 0.900
23256 340. 4.138 0.762
23238 342. 4.181 0.991
23228 305. 4.387 0.866
23220 357. 4.863 0.748
23183 278. 4.960 0.878
23184 285. 4.870 0.870
26497 343. 4.469 0.714
Page 1018 of 4796
26495 331. 4.396 0.749

26499 323. 4.786 0.836
26494 331. 4.302 0.619
26533 318. 4.387 0.742
26502 347. 4.346 0.775
26451 343. 4.417 0.682
26535 318. 4.274 0.708
26456 340. 4.126 0.691
26518 319. 4.329 0.853
26459 329. 4.362 0.772
MEAN 327. 4.564 0.789

S.D. 20.2 0.3337 0.0860
S.E. 4.3 0.0711 0.0183
N 22 22 22


-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
23198 319. 5.313 0.737
23233 354. 4.432 0.740
23241 346. 5.014 0.780
23239 345. 4.977 0.791
23245 301. 5.133 0.877
23223 353. 4.595 0.841
23191 325. 5.603 0.705
23247 349. 4.129 0.791
23230 362. 5.022 0.831
23249 330. 3.912 0.748
23258 313. 3.837 0.668
26478 338. 4.056 0.713
Page 1019 of 4796
26501 312. 4.769 0.782

26486 285. 4.375 0.786
26464 333. 4.336 0.757
26498 338. 4.201 0.781
26481 355. 4.710 0.713
26472 332. 4.262 0.741
26537 355. 4.327 0.820
26506 342. 4.398 0.719
26471 317. 4.618 0.744
26455 298. 4.336 0.711
MEAN 332. 4.562 0.763

S.D. 21.0 0.4618 0.0509
S.E. 4.5 0.0985 0.0108
N 22 22 22


-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
23255 297. 4.960 0.774
23215 329. 5.356 0.748
23214 324. 5.318 0.784
23192 279. 4.867 0.857
23219 326. 4.479 0.718
23211 326. 4.319 0.782
23189 319. 4.235 0.784
23204 314. 4.611 0.771
23257 376. 5.037 0.713
23234 346. 3.977 0.801
23227 349. 4.347 0.865
26509 350. 4.343 0.751
Page 1020 of 4796
26448 368. 4.418 0.745

26508 343. 4.245 0.808
26463 325. 3.963 0.751
26504 328. 4.439 0.765
26465 300. 4.727 0.783
26477 327. 4.107 0.716
26511 340. 4.326 0.703
26466 344. 4.294 0.735
26462 342. 4.567 0.772
26523 345. 4.258 0.690
26470 305. 5.026 0.715
MEAN 331. 4.531 0.762

S.D. 22.5 0.3951 0.0448
S.E. 4.7 0.0824 0.0093
N 23 23 23
POFBWv4.14
12/17/2008
R:01/12/2009
TABLE A21 (F1)
SPONSOR:ACC INDIVIDUAL LITTER VIABILITY
GROUP: 0 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23243 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
23213 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
23203 ALIVE 17 17 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
Page 1021 of 4796
CULLED 8
MISSING 1
SELECTE...ESTING 4
23207 ALIVE 14 14 14 14 8 8 8 8 7 7 7 7 7 7 7 7 7 7 7 7 7 0
SCHED. EUTH. 3
CULLED 6
MISSING 1
SELECTE...ESTING 4
23226 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
23242 ALIVE 17 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 9
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
SELECTE...ESTING= SELECTED FOR POST-WEANING BEHAVIORAL TESTING
SCHEDULED CULL DAY IS PND 4
TABLE A21 (F1)
GROUP: 0 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23209 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
23178 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
23186 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
Page 1022 of 4796
SELECTE...ESTING 4
23194 ALIVE 17 17 17 17 8 8 8 8 7 7 7 7 7 7 7 7 7 7 7 7 7 0
FOUND DEAD 1
SCHED. EUTH. 3
CULLED 8
MISSING 1
SELECTE...ESTING 4
23182 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
23240 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 0 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26521 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26449 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26473 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
Page 1023 of 4796
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
26452 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26491 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26512 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 5
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 0 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26454 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
26529 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26453 ALIVE 17 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 9
Page 1024 of 4796
SELECTE...ESTING 4
26527 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26489 ALIVE 18 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 2
SCHED. EUTH. 4
CULLED 9
MISSING 1
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 0.15 PPM

-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23195 ALIVE 12 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
23180 ALIVE 16 16 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
23176 ALIVE 16 16 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
Page 1025 of 4796
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
23251 ALIVE 15 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
MISSING 1
SELECTE...ESTING 4
23235 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 2 1
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
23231 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 5
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 0.15 PPM

-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23216 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
23261 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 5
SELECTE...ESTING 4
23205 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
Page 1026 of 4796
CULLED 8
SELECTE...ESTING 4
23181 ALIVE 14 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 5
MISSING 1
SELECTE...ESTING 4
23264 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 5
SELECTE...ESTING 4
26474 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 0.15 PPM

-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26476 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
26496 ALIVE 12 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
26505 ALIVE 12 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
Page 1027 of 4796
CULLED 4
SELECTE...ESTING 4
26483 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26479 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26450 ALIVE 18 18 18 18 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 10
SELECTE...ESTING 4
26457 ALIVE 17 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 9
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 0.15 PPM

-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26492 ALIVE 17 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 9
SELECTE...ESTING 4
26493 ALIVE 21 21 21 20 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1 1
SCHED. EUTH. 4
CULLED 11
SELECTE...ESTING 4
26488 ALIVE 11 11 11 11 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 3
Page 1028 of 4796
SCHED. EUTH. 4
CULLED 3
SELECTE...ESTING 4
26520 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 1.5 PPM

-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23248 ALIVE 17 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
23217 ALIVE 21 21 21 21 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 13
SELECTE...ESTING 4
23190 ALIVE 17 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
Page 1029 of 4796
CULLED 9
SELECTE...ESTING 4
23236 ALIVE 16 16 16 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1 1
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
23260 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
23221 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
23263 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 1.5 PPM

-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23253 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
23244 ALIVE 17 17 17 17 8 8 7 7 7 7 7 7 7 6 6 6 6 6 6 6 6 0
FOUND DEAD 1 1
SCHED. EUTH. 2
CULLED 9
SELECTE...ESTING 4
23218 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
Page 1030 of 4796
FOUND DEAD 1 1
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
23208 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
23252 ALIVE 17 17 16 16 8 8 8 8 7 7 7 7 7 7 7 7 7 7 7 7 7 0
FOUND DEAD 1 1
SCHED. EUTH. 3
CULLED 8
SELECTE...ESTING 4
26510 ALIVE 15 15 15 15 8 8 8 7 7 7 7 7 7 6 6 6 6 6 6 6 4 0
FOUND DEAD 1 1 2
SCHED. EUTH. 1
CULLED 7
SELECTE...ESTING 3
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 1.5 PPM

-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26519 ALIVE 15 15 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
MISSING 1
SELECTE...ESTING 4
26468 ALIVE 12 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
26475 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
Page 1031 of 4796
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26532 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26507 ALIVE 18 18 18 18 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 10
SELECTE...ESTING 4
26480 ALIVE 18 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
MISSING 2
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 1.5 PPM

-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26482 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 5
SELECTE...ESTING 4
26522 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26517 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
Page 1032 of 4796
SELECTE...ESTING 4
26514 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26534 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 75 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23179 ALIVE 10 10 10 10 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 2
SELECTE...ESTING 4
23212 ALIVE 18 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 9
SELECTE...ESTING 4
23201 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1 1
Page 1033 of 4796
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
23259 ALIVE 13 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 4
MISSING 1
SELECTE...ESTING 4
23210 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
23256 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 75 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23238 ALIVE 19 18 18 18 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 10
MISSING 1
SELECTE...ESTING 4
23228 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
23246 ALIVE 7 7 7 7 0
SCHEDUL...OT MET 7
Page 1034 of 4796
23220 ALIVE 18 18 18 18 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 10
SELECTE...ESTING 4
23183 ALIVE 12 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 3
SELECTE...ESTING 4
23184 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26516 ALIVE 10 5 5 5 0
FOUND DEAD 5 5
SCHEDUL...OT MET 5
-----------------------------------------------------------------------------------------------------------------------------------
SCHEDUL...OT MET= SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET
TABLE A21 (F1)
GROUP: 75 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26497 ALIVE 16 16 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 7
MISSING 1
SELECTE...ESTING 4
26495 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26499 ALIVE 17 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
Page 1035 of 4796
CULLED 8
MISSING 1
SELECTE...ESTING 4
26494 ALIVE 12 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
26533 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26502 ALIVE 14 14 14 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 3
SCHED. EUTH. 4
CULLED 5
MISSING 1
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 75 PPM
-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26451 ALIVE 16 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 7
MISSING 1
SELECTE...ESTING 4
26535 ALIVE 17 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 9
SELECTE...ESTING 4
26456 ALIVE 18 18 18 18 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
Page 1036 of 4796
SCHED. EUTH. 4
CULLED 10
SELECTE...ESTING 4
26518 ALIVE 12 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
26459 ALIVE 10 10 10 10 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 3
SCHED. EUTH. 4
CULLED 2
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 750 PPM

-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23198 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
23233 ALIVE 9 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0
FOUND DEAD 3 1
SCHED. EUTH. 3
MISSING 1
SELECTE...ESTING 4
23241 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
Page 1037 of 4796
CULLED 5
SELECTE...ESTING 4
23254 ALIVE 11 11 11 11 0
CULLED 3
SCHEDUL...OT MET 8
23239 ALIVE 12 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
23245 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 5
SELECTE...ESTING 4
23223 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 750 PPM

-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23191 ALIVE 16 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
23247 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
23230 ALIVE 16 16 16 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
Page 1038 of 4796
CULLED 7
MISSING 1
SELECTE...ESTING 4
23249 ALIVE 11 11 11 11 8 8 8 8 8 8 8 7 5 5 4 4 4 4 4 4 4 0
FOUND DEAD 2 1 2 1
SCHED. EUTH. 2
CULLED 3
SELECTE...ESTING 2
23258 ALIVE 12 12 12 12 8 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0
EUTH. EXTREMIS 1
SCHED. EUTH. 3
CULLED 4
SELECTE...ESTING 4
26485 ALIVE 14 14 14 14 0
CULLED 6
SCHEDUL...OT MET 8
-----------------------------------------------------------------------------------------------------------------------------------
EUTH. EXTREMIS= EUTHANIZED IN EXTREMIS, SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY
TABLE A21 (F1)
GROUP: 750 PPM

-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26478 ALIVE 12 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
26501 ALIVE 17 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 9
SELECTE...ESTING 4
26486 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
Page 1039 of 4796
SELECTE...ESTING 4
26464 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 5
SELECTE...ESTING 4
26498 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26481 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26472 ALIVE 18 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 9
MISSING 1
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 750 PPM

-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26537 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26506 ALIVE 17 17 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
MISSING 1
SELECTE...ESTING 4
26471 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
Page 1040 of 4796
CULLED 6
SELECTE...ESTING 4
26455 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 2250 PPM

-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23255 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
23237 ALIVE 0
DEATH OF DAM 12
23215 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
Page 1041 of 4796
23214 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
23192 ALIVE 13 12 12 12 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 4
SELECTE...ESTING 4
23219 ALIVE 15 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 6
MISSING 1
SELECTE...ESTING 4
23211 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
SCHED. EUTH.= SCHEDULED EUTHANASIA, CULLED= CULLED ON SCHEDULED DAY, DEATH OF DAM= SENT TO NECROPSY DUE TO DEATH OF DAM
TABLE A21 (F1)
GROUP: 2250 PPM

-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23189 ALIVE 18 18 18 18 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 10
SELECTE...ESTING 4
23204 ALIVE 18 17 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1 2
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
23257 ALIVE 17 17 17 16 8 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 0
FOUND DEAD 1 1
Page 1042 of 4796
SCHED. EUTH. 3
CULLED 8
SELECTE...ESTING 4
23234 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
23227 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26509 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 5
SELECTE...ESTING 4
26448 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 2250 PPM

-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26508 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
26463 ALIVE 15 15 15 15 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 7
SELECTE...ESTING 4
26504 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
Page 1043 of 4796
SELECTE...ESTING 4
26465 ALIVE 15 14 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 5
MISSING 1 1
SELECTE...ESTING 4
26477 ALIVE 13 13 13 13 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 5
SELECTE...ESTING 4
26511 ALIVE 14 14 14 14 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 6
SELECTE...ESTING 4
26466 ALIVE 17 17 17 17 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
SCHED. EUTH. 4
CULLED 9
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A21 (F1)
GROUP: 2250 PPM

-----------------------------------------------------------------------------------------------------------------------------------
DAM # PND 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26462 ALIVE 17 17 17 16 8 8 8 8 7 7 7 7 7 7 7 7 7 7 7 7 7 0
FOUND DEAD 1 1
SCHED. EUTH. 3
CULLED 7
MISSING 1
SELECTE...ESTING 4
26523 ALIVE 17 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
Page 1044 of 4796
26470 ALIVE 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 0
FOUND DEAD 1
SCHED. EUTH. 4
CULLED 8
SELECTE...ESTING 4
-----------------------------------------------------------------------------------------------------------------------------------
PPVIAv4.02
12/17/2008
TABLE A22 (F1)
SPONSOR:ACC INDIVIDUAL PUP VIABILITY
--------------------------------------------------------
LITTERS FROM GROUP 1: 0 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23243 04-AUG-08 a21 e21 a21 C e21 C C C C a21 C e21 C e21 a21
M M M M M M M M M F F F F F F
23213 05-AUG-08 0 e21 e21 a21 C C C a21 a21 e21 C C e21 C a21
M M M M F F F F F F F F F F F
23203 06-AUG-08 a21 C C a21 e21 C 2 e21 a21 C C e21 e21 C a21 C C
M M M M M M M M F F F F F F F F F
23207 05-AUG-08 e21 e21 a21 a21 C e21 C C a21 8 C C C e21

M M M M F F F F F F F F F F
Page 1045 of 4796
23226 06-AUG-08 a21 e21 e21 a21 a21 C C e21 C a21 C C e21 4 C
23242 06-AUG-08 C C C e21 a21 e21 C a21 C C a21 C C C e21 e21 a21
23209 07-AUG-08 C C e21 C a21 e21 C a21 C C C a21 C e21 e21 a21
M M M M M M M M M F F F F F F F
23178 07-AUG-08 a21 C e21 a21 C C e21 C C C e21 a21 e21 a21 C
M M M M M M M M F F F F F F F
23186 06-AUG-08 e21 e21 a21 C a21 C e21 e21 a21 C a21 C C C
M M M M M M F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
A = ALIVE, NUMBER INDICATES POSTNATAL DAY WHEN DEATH OCCURRED, C = CULLED DAY 4
M = MALE, F = FEMALE, U = UNDETERMINED
a=SCHEDULED EUTHANASIA
e=SELECTED FOR POST-WEANING BEHAVIORAL TESTING
TABLE A22 (F1)
--------------------------------------------------------
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23194 07-AUG-08 e21 C 8 a21 C e21 C C C a21 C C e21 C a21 4 e21
23182 08-AUG-08 C C e21 a21 a21 C e21 C C a21 e21 a21 C C e21 C
M M M M M M M F F F F F F F F F
23240 08-AUG-08 0 a21 C C e21 e21 C a21 C C C e21 e21 a21 a21
M M M M M M M M M M M F F F F
26521 03-SEP-08 0 e21 e21 C a21 C C a21 C C C e21 C a21 C e21 a21
F M M M M M M M M M F F F F F F F
Page 1046 of 4796
26449 03-SEP-08 0 C C C e21 C e21 a21 a21 C C a21 C a21 e21 C e21
M M M M M M M M M M F F F F F F F
26473 03-SEP-08 C C e21 a21 a21 e21 C C a21 a21 e21 C e21 C C
M M M M M M M F F F F F F F F
26452 04-SEP-08 0 e21 a21 C a21 C C C C C e21 C a21 C e21 e21 a21
M M M M M M M M M M M F F F F F F
26491 04-SEP-08 C e21 a21 a21 e21 C a21 C e21 a21 C C C e21
26512 04-SEP-08 e21 a21 e21 C e21 a21 a21 C C C a21 C e21
M M M F F F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A22 (F1)
--------------------------------------------------------
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26454 04-SEP-08 e21 e21 C a21 a21 C C a21 C C e21 C C a21 e21
M M M M M F F F F F F F F F F
26529 04-SEP-08 a21 e21 a21 e21 C C C C C a21 C a21 C e21 C e21
M M M M M F F F F F F F F F F F
26453 04-SEP-08 C C C C e21 C C C a21 C a21 C e21 a21 a21 e21 e21
M M M M M M M M M M M M M F F F F
26527 04-SEP-08 C C e21 C a21 a21 e21 C C C e21 a21 a21 e21
M M M M M M M M F F F F F F
Page 1047 of 4796
26489 05-SEP-08 0 0 C C C C e21 e21 a21 C a21 C a21 C e21 a21 e21 C C 1
F F M M M M M M M M M F F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A22 (F1)
--------------------------------------------------------
LITTERS FROM GROUP 2: 0.15 PPM
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23195 05-AUG-08 a21 C C e21 a21 e21 C a21 C e21 a21 e21
M M M M M M M M M F F F
23180 06-AUG-08 C a21 e21 2 C a21 e21 C C a21 e21 e21 C C a21 C
M M M M M M M M F F F F F F F F
23176 05-AUG-08 e21 e21 a21 C C a21 C C C a21 C e21 a21 e21 2 C
23251 06-AUG-08 e21 e21 C C a21 C C C C a21 a21 a21 e21 1 e21
M M M M M M M M M M F F F F F
Page 1048 of 4796
23235 06-AUG-08 0 0 4 a21 a21 e21 a21 e21 a21 e21 C C C e21 C
F F M M M M F M F F F F F F F
23231 06-AUG-08 C C e21 a21 C a21 e21 C C a21 a21 e21 e21
M M M M M M M M M F F F F
23216 07-AUG-08 0 e21 a21 C e21 C C a21 C C e21 C C C a21 a21 e21
F M M M M M M M M M F F F F F F F
23261 07-AUG-08 e21 a21 C e21 a21 C a21 C a21 e21 C e21 C
M M M M M M F F F F F F F
23205 07-AUG-08 a21 e21 C e21 a21 C a21 C C a21 C C C e21 C e21
M M M M M M F F F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A22 (F1)
--------------------------------------------------------
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23181 08-AUG-08 C C e21 e21 a21 1 a21 a21 C C e21 e21 C a21
M M M M M M M F F F F F F F
23264 07-AUG-08 0 a21 a21 e21 e21 C e21 C C a21 a21 C e21 C
F M M M M M F F F F F F F F
26474 03-SEP-08 0 e21 a21 C e21 C C a21 C C C a21 e21 e21 C C a21
26476 03-SEP-08 0 C a21 C a21 e21 C e21 e21 C e21 C a21 C C a21
F M M M M M M M F F F F F F F F
Page 1049 of 4796
26496 03-SEP-08 a21 e21 a21 C e21 e21 e21 a21 C a21 C C
M M M M M F F F F F F F
26505 04-SEP-08 e21 C C a21 e21 C a21 C a21 e21 a21 e21
M M M M M M M M F F F F
26483 04-SEP-08 a21 e21 C e21 C C C a21 e21 C a21 a21 e21 C
26479 04-SEP-08 a21 e21 e21 C a21 a21 e21 C C a21 C e21 C C
M M M M M F F F F F F F F F
26450 04-SEP-08 C e21 C C a21 e21 C a21 C C C C C C e21 e21 a21 a21
M M M M M M M M M F F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A22 (F1)
--------------------------------------------------------
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26457 03-SEP-08 C C e21 e21 C C C C a21 C a21 e21 C a21 e21 a21 C
M M M M M M M M M F F F F F F M F
26492 03-SEP-08 C C e21 C C a21 a21 C C a21 C e21 e21 a21 C C e21
M M M M M M M M M F F F F F F F M
26493 04-SEP-08 4 C C e21 C a21 a21 C C 3 e21 C C a21 C e21 C a21 C e21 C
M M M M M M M M M M M M F F F F F F F F F
26488 05-SEP-08 0 0 0 C a21 e21 e21 a21 a21 C a21 e21 C e21
F M F M M M M M F F F F F F
Page 1050 of 4796
26520 05-SEP-08 e21 a21 e21 a21 a21 C C e21 C C e21 C a21 C C C
M M M M F F F F F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A22 (F1)
--------------------------------------------------------
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23248 04-AUG-08 1 C C C e21 a21 C e21 a21 a21 C C e21 e21 C a21 C
F M M M M M M M M F F F F F F F F
23217 05-AUG-08 C C a21 e21 C C C e21 a21 e21 a21 C C C C C C a21 C C e21
M M M M M M M M M F F F F F F F F F F F F
23190 05-AUG-08 a21 C e21 e21 a21 C C a21 C C C e21 C C a21 C e21
M M M M M M M F F F F F F F F F F
23236 06-AUG-08 a21 C C C C e21 a21 C e21 3 C e21 a21 e21 a21 4
M M M M M M M M M M F F F F F F
Page 1051 of 4796
23260 06-AUG-08 e21 C C e21 C a21 a21 C C e21 e21 a21 C a21
23221 07-AUG-08 a21 C C a21 C e21 e21 C C e21 a21 a21 C e21
23263 07-AUG-08 C a21 C C C e21 C e21 a21 e21 C C a21 e21 a21
M M M M M M M M M F F F F F F
23253 07-AUG-08 0 C e21 e21 a21 C C a21 C C C C C e21 a21 e21 a21
M M M M M M M M M M M M F F F F F
23244 07-AUG-08 13 C C e21 C C e21 C a21 C 6 C a21 C C e21 e21

-----------------------------------------------------------------------------------------------------------------------------------
TABLE A22 (F1)
--------------------------------------------------------
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23218 07-AUG-08 0 C e21 C a21 4 C a21 C C a21 C C e21 e21 e21 a21
F M M M M M M M M F F F F M F F F
23208 07-AUG-08 a21 C C a21 e21 C C e21 C C a21 a21 e21 e21
23252 08-AUG-08 e21 2 e21 C C 8 a21 C C C C e21 a21 C a21 e21 C

26510 02-SEP-08 C e21 a21 7 C C C C e21 C C e21 13 20 20

M M M M M M M M M M F F F F F
Page 1052 of 4796
26519 02-SEP-08 C 2 a21 e21 C a21 e21 e21 a21 C a21 C C C e21
F M M M M M M F F F F F F F F
26468 03-SEP-08 0 a21 e21 e21 a21 C C C e21 a21 C a21 e21
F M M M M M M M F F F F F
26475 04-SEP-08 a21 a21 e21 C e21 a21 C C e21 C C C a21 e21
M M M F M F F F F F F F F F
26532 03-SEP-08 C C e21 e21 C a21 C a21 C e21 C C a21 a21 C e21
26507 03-SEP-08 C a21 e21 e21 C C C a21 C C C C a21 e21 C e21 C a21
F M M M M M M M M F F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A22 (F1)
--------------------------------------------------------
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26480 04-SEP-08 C a21 a21 e21 e21 C C 1 C C e21 C e21 C a21 a21 1 C
M M M M M M M M M F F F F F F F F F
26482 04-SEP-08 e21 C a21 C e21 a21 a21 C C C a21 e21 e21
26522 04-SEP-08 e21 a21 a21 e21 a21 a21 C C C e21 C e21 C C
M M M M F F F F F F F F F F
26517 05-SEP-08 C a21 e21 e21 a21 C C a21 C C C e21 C e21 C a21
Page 1053 of 4796
26514 05-SEP-08 a21 C C C C e21 e21 a21 C C C C a21 e21 e21 a21
26534 05-SEP-08 e21 C C a21 a21 e21 C a21 C a21 C C e21 C C e21
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A22 (F1)
--------------------------------------------------------
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23179 05-AUG-08 a21 a21 e21 e21 C e21 C e21 a21 a21
M M M M F F F F F F
23212 06-AUG-08 1 e21 C C C C e21 a21 a21 C e21 C C C e21 a21 a21 C
F M M M M M M M M F F F F F F F F F
23201 06-AUG-08 0 e21 a21 e21 C e21 C e21 a21 C a21 4 C a21
F M M M F F F F F F F F F F
23259 07-AUG-08 1 e21 a21 C e21 a21 C C e21 a21 e21 C a21
F M M M M M F F F F F F F
Page 1054 of 4796
23210 07-AUG-08 a21 C e21 C C a21 C C e21 C C a21 C e21 a21 e21
23256 07-AUG-08 C C C a21 C C a21 e21 e21 C e21 C e21 a21 C a21
23238 07-AUG-08 C a21 e21 e21 C C a21 e21 a21 C C C e21 C C a21 C C 1
M M M M M M M F F F F F F F F F F F F
23228 07-AUG-08 C C a21 e21 a21 C e21 a21 C e21 a21 e21 C C C C
23246 07-AUG-08 b4 b4 b4 b4 b4 b4 b4
M M M M M F F
-----------------------------------------------------------------------------------------------------------------------------------
b=SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET
TABLE A22 (F1)
--------------------------------------------------------
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23220 07-AUG-08 C C C C C C a21 a21 e21 C e21 C a21 a21 e21 C C e21
M M M M M M M M M M M M F F F F F F
23183 08-AUG-08 a21 C C e21 4 e21 a21 e21 C a21 a21 e21
M M M M M M M F F F F F
23184 08-AUG-08 e21 C a21 C C e21 a21 e21 C C C C C a21 e21 a21
26516 02-SEP-08 0 0 1 1 b4 0 0 0 1 1 b4 b4 b4 b4 1
M M M M M F F F F F M M F F F
Page 1055 of 4796
26497 03-SEP-08 e21 C 2 C C e21 C C a21 a21 a21 C e21 C a21 e21
26495 03-SEP-08 e21 C e21 C a21 a21 C C a21 a21 C e21 C e21
26499 04-SEP-08 C 1 C a21 C e21 e21 a21 C e21 a21 e21 C a21 C C C
26494 03-SEP-08 e21 C a21 e21 C a21 C a21 e21 a21 C e21
M M M M M M F F F F F F
26533 04-SEP-08 0 C a21 C e21 e21 a21 e21 e21 C C a21 C a21 C
U M M M M M M F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A22 (F1)
--------------------------------------------------------
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26502 04-SEP-08 0 0 0 a21 e21 C C C e21 a21 e21 a21 e21 3 a21 C C
M M F M M M M M M M F F F F F F F
26451 04-SEP-08 0 e21 C e21 C a21 a21 1 C a21 a21 e21 e21 C C C C
F M M M M M M F F F F F F F F F F
26535 04-SEP-08 C C e21 a21 e21 C C a21 C C e21 C a21 e21 C a21 C
M M M M M M M M M F F F F F F F M
26456 04-SEP-08 e21 C C C a21 C C a21 C C e21 C C a21 a21 e21 C e21
M M M M M M M M M M M M F F F F F F
Page 1056 of 4796
26518 05-SEP-08 C a21 a21 e21 C e21 a21 e21 C a21 C e21
M M M M M M F F F F F F
26459 05-SEP-08 0 0 0 a21 e21 e21 a21 C a21 a21 e21 e21 C
M M F M M M M F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A22 (F1)
--------------------------------------------------------
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23198 05-AUG-08 a21 C C C C e21 a21 e21 C C a21 e21 C a21 e21
M M M M M M M M F F F F F F F
23233 05-AUG-08 0 0 0 e21 a21 1 a21 e21 e21 a21 e21 1

M F F M M M M M F F F F
23241 06-AUG-08 C C a21 a21 e21 e21 C a21 e21 e21 a21 C C
M M M M M M M F F F F F F
23254 08-AUG-08 b4 b4 b4 C C b4 b4 C b4 b4 b4
M M F F F F F F F F F
Page 1057 of 4796
23239 07-AUG-08 0 e21 e21 a21 a21 C C a21 e21 a21 C C e21
F M M M M F F F F F F F F
23245 06-AUG-08 0 a21 a21 e21 e21 C a21 C C a21 e21 C C e21
23223 07-AUG-08 C a21 C C e21 a21 C e21 C C e21 C a21 C e21 a21
23191 07-AUG-08 e21 1 C a21 C e21 C C a21 C a21 a21 C e21 e21 C
23247 07-AUG-08 C a21 C C e21 a21 e21 C C C C a21 e21 C a21 e21
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A22 (F1)
--------------------------------------------------------
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23230 06-AUG-08 C C a21 C a21 e21 e21 C 3 e21 a21 e21 C C a21 C
23249 08-AUG-08 0 0 a21 14 11 12 C C C 12 a21 e21 e21

M F M M M M M M M M F F F
23258 08-AUG-08 e21 a21 e21 C a21 C C a21 5 e21 e21 C

M M M M M M M F F F F F
26485 02-SEP-08 C b4 b4 b4 C C C C b4 b4 b4 C b4 b4
M M M M M M M M M M M M F F
Page 1058 of 4796
26478 03-SEP-08 a21 a21 e21 e21 C C e21 a21 e21 a21 C C
M M M M F F F F F F F F
26501 03-SEP-08 C C a21 C C e21 a21 e21 C e21 C C C C a21 e21 a21
M M M M M M M M M F F F F F F F F
26486 04-SEP-08 e21 e21 a21 C a21 C C a21 C e21 C C a21 e21
26464 04-SEP-08 C a21 e21 C a21 e21 C e21 a21 e21 a21 C C
26498 03-SEP-08 C C e21 e21 a21 a21 C C a21 C C a21 C e21 e21 C
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A22 (F1)
--------------------------------------------------------
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26481 04-SEP-08 a21 C a21 C C e21 e21 e21 C C a21 C e21 C C a21
26472 03-SEP-08 1 e21 C C C a21 C a21 C e21 C e21 a21 e21 a21 C C C
F F M M M M M M M M M M F F F F F F
26537 04-SEP-08 e21 C C a21 C C C a21 a21 e21 a21 C e21 C e21 C
M M M M M M M M F F F F M F F F
26506 03-SEP-08 C a21 e21 a21 e21 C C C e21 2 C e21 a21 C C C a21
M M M M M F F F F F F F F F F F F
Page 1059 of 4796
26471 05-SEP-08 C e21 C C C C a21 a21 e21 e21 e21 C a21 a21
M M M M M M M M M F F F F F
26455 05-SEP-08 e21 a21 C C e21 a21 C C e21 e21 a21 a21 C C
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A22 (F1)
--------------------------------------------------------
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23255 05-AUG-08 C a21 C e21 e21 C C a21 C C e21 a21 C e21 C a21
23237 06-AUG-08 d0 d0 d0 d0 d0 d0 d0 d0 d0 d0 d0 d0
M M M M F F F F F F F F
23215 06-AUG-08 C e21 a21 C e21 a21 C C C C a21 a21 e21 C e21 C
23214 06-AUG-08 C a21 C C e21 C e21 a21 C a21 e21 e21 C a21
M M M M M M M M M F F F F F
Page 1060 of 4796
23192 06-AUG-08 a21 C e21 C 1 C C e21 a21 e21 a21 a21 e21
M M M M M M M M M F F F F
23219 07-AUG-08 0 C C 1 e21 e21 C C C a21 a21 e21 a21 a21 e21 C
F M M M M M M M M M M F F F F F
23211 07-AUG-08 a21 e21 C e21 a21 C C C C C e21 a21 a21 e21
M M M M M M M M M M F F F F
23189 07-AUG-08 e21 C e21 C C a21 a21 C C a21 C a21 C C e21 C C e21
M M M M M M M F F F F F F F F F F F
23204 07-AUG-08 C 2 1 C C C C e21 C a21 a21 e21 2 e21 C a21 e21 a21
M M M M M M M M M M M M M F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
d=SENT TO NECROPSY DUE TO DEATH OF DAM
TABLE A22 (F1)
--------------------------------------------------------
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
23257 06-AUG-08 3 C C e21 a21 a21 C C e21 C e21 a21 C C e21 5 C
23234 07-AUG-08 a21 e21 e21 a21 C a21 C e21 e21 C C C C a21 C
23227 07-AUG-08 C a21 C C e21 C e21 C a21 C e21 e21 C a21 a21 C
26509 02-SEP-08 C a21 a21 e21 e21 C C e21 C a21 a21 C e21
Page 1061 of 4796
26448 03-SEP-08 C e21 C a21 a21 C C e21 C C e21 a21 e21 a21 C
F M M M M M M M M M F F F F F
26508 03-SEP-08 C C a21 e21 C C a21 e21 e21 C a21 C a21 e21 C C
26463 04-SEP-08 C a21 C e21 C e21 a21 e21 e21 C C a21 C a21 C
M M M M M M M F F F F F F F F
26504 03-SEP-08 a21 e21 a21 e21 C C a21 e21 C e21 a21 C C C
26465 04-SEP-08 C a21 1 e21 C C C e21 a21 a21 C e21 e21 a21 2
M M M M M M M M M M M F F F F
-----------------------------------------------------------------------------------------------------------------------------------
TABLE A22 (F1)
--------------------------------------------------------
--------------------------------------------------------
DAY OF
DAM # BIRTH PUP # 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
-----------------------------------------------------------------------------------------------------------------------------------
26477 04-SEP-08 C e21 e21 C a21 a21 C e21 C e21 a21 C a21
26511 04-SEP-08 e21 a21 C C e21 a21 e21 C C C a21 a21 C e21
26466 04-SEP-08 C a21 a21 C C C C e21 e21 C a21 a21 e21 C C e21 C
26462 04-SEP-08 a21 e21 C 8 C e21 C C e21 4 C C e21 C a21 3 a21

M M M M M M F F F F F F F F F F F
Page 1062 of 4796
26523 04-SEP-08 e21 C 1 C a21 e21 C C a21 C a21 C C e21 C a21 e21
M M M M M M M M M F F F F F F F F
26470 05-SEP-08 0 C C a21 e21 e21 a21 a21 e21 a21 e21 C C C C C C
F M M M M M M F F F F F F F F F F
-----------------------------------------------------------------------------------------------------------------------------------
PLITRv4.02
12/17/2008
TABLE A23 (F1)
SPONSOR:ACC INDIVIDUAL POSTNATAL SURVIVAL [% PER LITTER]
--------------------------------------------
--------------------------------------------
ANIMAL 0 0- 1 1- 4 4- 7 7-14 14-21 B- 4 4-21
-----------------------------------------------------------------------------------------------------------------------------------
23243 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23213 93.3 100.0 100.0 100.0 100.0 100.0 93.3 100.0
23203 100.0 100.0 94.1 100.0 100.0 100.0 94.1 100.0
23207 100.0 100.0 100.0 100.0 87.5 100.0 100.0 87.5
23226 100.0 100.0 93.3 100.0 100.0 100.0 93.3 100.0
23242 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23209 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23178 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23186 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23194 100.0 100.0 94.1 100.0 87.5 100.0 94.1 87.5
23182 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23240 93.3 100.0 100.0 100.0 100.0 100.0 93.3 100.0
Page 1063 of 4796
26521 94.1 100.0 100.0 100.0 100.0 100.0 94.1 100.0

26449 94.1 100.0 100.0 100.0 100.0 100.0 94.1 100.0
26473 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26452 94.1 100.0 100.0 100.0 100.0 100.0 94.1 100.0
26491 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26512 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26454 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26529 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26453 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26527 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26489 90.0 94.4 100.0 100.0 100.0 100.0 85.0 100.0
MEAN 98.2 99.8 99.2 100.0 98.9 100.0 97.2 98.9

S.D. 3.16 1.16 2.12 0.00 3.60 0.00 3.99 3.60
S.E. 0.66 0.24 0.44 0.00 0.75 0.00 0.83 0.75
N 23 23 23 23 23 23 23 23
B = BIRTH
TABLE A23 (F1)
--------------------------------------------
--------------------------------------------
ANIMAL 0 0- 1 1- 4 4- 7 7-14 14-21 B- 4 4-21
-----------------------------------------------------------------------------------------------------------------------------------
23195 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23180 100.0 100.0 93.8 100.0 100.0 100.0 93.8 100.0
23176 100.0 100.0 93.8 100.0 100.0 100.0 93.8 100.0
23251 100.0 93.3 100.0 100.0 100.0 100.0 93.3 100.0
23235 86.7 100.0 92.3 100.0 100.0 100.0 80.0 100.0
23231 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23216 94.1 100.0 100.0 100.0 100.0 100.0 94.1 100.0
23261 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23205 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23181 100.0 92.9 100.0 100.0 100.0 100.0 92.9 100.0
23264 92.9 100.0 100.0 100.0 100.0 100.0 92.9 100.0
26474 94.1 100.0 100.0 100.0 100.0 100.0 94.1 100.0
Page 1064 of 4796
26476 93.8 100.0 100.0 100.0 100.0 100.0 93.8 100.0

26496 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26505 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26483 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26479 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26450 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26457 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26492 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26493 100.0 100.0 90.5 100.0 100.0 100.0 90.5 100.0
26488 78.6 100.0 100.0 100.0 100.0 100.0 78.6 100.0
26520 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
MEAN 97.4 99.4 98.7 100.0 100.0 100.0 95.5 100.0

S.D. 5.39 1.99 2.94 0.00 0.00 0.00 6.13 0.00
S.E. 1.12 0.42 0.61 0.00 0.00 0.00 1.28 0.00
N 23 23 23 23 23 23 23 23
B = BIRTH
TABLE A23 (F1)
--------------------------------------------
--------------------------------------------
ANIMAL 0 0- 1 1- 4 4- 7 7-14 14-21 B- 4 4-21
-----------------------------------------------------------------------------------------------------------------------------------
23248 100.0 94.1 100.0 100.0 100.0 100.0 94.1 100.0
23217 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23190 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23236 100.0 100.0 87.5 100.0 100.0 100.0 87.5 100.0
23260 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23221 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23263 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23253 94.1 100.0 100.0 100.0 100.0 100.0 94.1 100.0
23244 100.0 100.0 100.0 87.5 85.7 100.0 100.0 75.0
23218 94.1 100.0 93.8 100.0 100.0 100.0 88.2 100.0
23208 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23252 100.0 100.0 94.1 100.0 87.5 100.0 94.1 87.5
Page 1065 of 4796
26510 100.0 100.0 100.0 87.5 85.7 66.7 100.0 50.0

26519 100.0 100.0 93.3 100.0 100.0 100.0 93.3 100.0
26468 92.3 100.0 100.0 100.0 100.0 100.0 92.3 100.0
26475 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26532 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26507 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26480 100.0 88.9 100.0 100.0 100.0 100.0 88.9 100.0
26482 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26522 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26517 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26514 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26534 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
MEAN 99.2 99.3 98.7 99.0 98.3 98.6 97.2 96.4

S.D. 2.21 2.52 3.19 3.53 4.64 6.80 4.36 11.35
S.E. 0.45 0.51 0.65 0.72 0.95 1.39 0.89 2.32
N 24 24 24 24 24 24 24 24
B = BIRTH
TABLE A23 (F1)
--------------------------------------------
--------------------------------------------
ANIMAL 0 0- 1 1- 4 4- 7 7-14 14-21 B- 4 4-21
-----------------------------------------------------------------------------------------------------------------------------------
23179 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23212 100.0 94.4 100.0 100.0 100.0 100.0 94.4 100.0
23201 92.9 100.0 92.3 100.0 100.0 100.0 85.7 100.0
23259 100.0 92.3 100.0 100.0 100.0 100.0 92.3 100.0
23210 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23256 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23238 100.0 94.7 100.0 100.0 100.0 100.0 94.7 100.0
23228 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23246 100.0 100.0 100.0 NA NA NA 100.0 NA
23220 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23183 100.0 100.0 91.7 100.0 100.0 100.0 91.7 100.0
23184 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
Page 1066 of 4796
26516 66.7 50.0 100.0 NA NA NA 33.3 NA

26497 100.0 100.0 93.8 100.0 100.0 100.0 93.8 100.0
26495 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26499 100.0 94.1 100.0 100.0 100.0 100.0 94.1 100.0
26494 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26533 93.3 100.0 100.0 100.0 100.0 100.0 93.3 100.0
26502 82.4 100.0 92.9 100.0 100.0 100.0 76.5 100.0
26451 94.1 93.8 100.0 100.0 100.0 100.0 88.2 100.0
26535 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26456 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26518 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26459 76.9 100.0 100.0 100.0 100.0 100.0 76.9 100.0
MEAN 96.1 96.6 98.8 100.0 100.0 100.0 92.3 100.0

S.D. 8.65 10.26 2.82 0.00 0.00 0.00 14.38 0.0
S.E. 1.76 2.09 0.58 0.00 0.00 0.00 2.93 0.0
N 24 24 24 22 22 22 24 22
B = BIRTH
TABLE A23 (F1)
--------------------------------------------
--------------------------------------------
ANIMAL 0 0- 1 1- 4 4- 7 7-14 14-21 B- 4 4-21
-----------------------------------------------------------------------------------------------------------------------------------
23198 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23233 75.0 77.8 100.0 100.0 100.0 100.0 58.3 100.0
23241 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23254 100.0 100.0 100.0 NA NA NA 100.0 NA
23239 92.3 100.0 100.0 100.0 100.0 100.0 92.3 100.0
23245 92.9 100.0 100.0 100.0 100.0 100.0 92.9 100.0
23223 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23191 100.0 93.8 100.0 100.0 100.0 100.0 93.8 100.0
23247 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23230 100.0 100.0 93.8 100.0 100.0 100.0 93.8 100.0
23249 84.6 100.0 100.0 100.0 50.0 100.0 84.6 50.0
23258 100.0 100.0 100.0 87.5 100.0 100.0 100.0 87.5
Page 1067 of 4796
26485 100.0 100.0 100.0 NA NA NA 100.0 NA

26478 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26501 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26486 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26464 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26498 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26481 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26472 100.0 94.4 100.0 100.0 100.0 100.0 94.4 100.0
26537 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26506 100.0 100.0 94.1 100.0 100.0 100.0 94.1 100.0
26471 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26455 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
MEAN 97.7 98.6 99.5 99.4 97.7 100.0 96.0 97.2

S.D. 6.06 4.73 1.71 2.67 10.66 0.00 8.95 10.86
S.E. 1.24 0.97 0.35 0.57 2.27 0.00 1.83 2.32
N 24 24 24 22 22 22 24 22
B = BIRTH
TABLE A23 (F1)
--------------------------------------------
--------------------------------------------
ANIMAL 0 0- 1 1- 4 4- 7 7-14 14-21 B- 4 4-21
-----------------------------------------------------------------------------------------------------------------------------------
23255 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23237 100.0 NA NA NA NA NA NA NA
23215 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23214 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23192 100.0 92.3 100.0 100.0 100.0 100.0 92.3 100.0
23219 93.8 93.3 100.0 100.0 100.0 100.0 87.5 100.0
23211 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23189 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23204 100.0 94.4 88.2 100.0 100.0 100.0 83.3 100.0
23257 100.0 100.0 94.1 87.5 100.0 100.0 94.1 87.5
23234 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
23227 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
Page 1068 of 4796
26509 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0

26448 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26508 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26463 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26504 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26465 100.0 93.3 92.9 100.0 100.0 100.0 86.7 100.0
26477 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26511 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26466 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0
26462 100.0 100.0 88.2 100.0 87.5 100.0 88.2 87.5
26523 100.0 94.1 100.0 100.0 100.0 100.0 94.1 100.0
26470 94.1 100.0 100.0 100.0 100.0 100.0 94.1 100.0
MEAN 99.5 98.6 98.4 99.5 99.5 100.0 96.5 98.9

S.D. 1.71 2.76 3.72 2.61 2.61 0.00 5.39 3.60
S.E. 0.35 0.58 0.78 0.54 0.54 0.00 1.12 0.75
N 24 23 23 23 23 23 23 23
B = BIRTH
PPVIASv5.07
12/17/2008
R:09/18/2009
TABLE A24 (F1)
SPONSOR:ACC INDIVIDUAL PUP CLINICAL OBSERVATIONS

-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 1: 0 PPM PUP # SEX PUP GROSS OBSERVATION POSTNATAL DAY
-----------------------------------------------------------------------------------------------------------------------------------
23243 1 M NO REMARKABLE OBSERVATIONS 4
NO REMARKABLE OBSERVATIONS 11
SCHEDULED EUTHANASIA 21
2 M NO REMARKABLE OBSERVATIONS 4
SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
Page 1069 of 4796
CULLED ON SCHEDULED DAY 4

10 F NO REMARKABLE OBSERVATIONS 4
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
23243 10 F NO REMARKABLE OBSERVATIONS 21
Page 1070 of 4796

23213 1 M FOUND DEAD 0

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1071 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1072 of 4796
7 M MISSING 2
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1073 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1074 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
23207 8 F CULLED ON SCHEDULED DAY 4
MISSING 8
Page 1075 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1076 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
14 F FOUND DEAD 4

Page 1077 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1078 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1079 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
23209 9 M CULLED ON SCHEDULED DAY 4
Page 1080 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1081 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1082 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1083 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
23194 1 M SUBCUTANEOUS HEMORRHAGE(S) 0

RIGHT HINDLIMB
3 M BODY PALE 4
Page 1084 of 4796
FOUND DEAD 8
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1085 of 4796

16 F MISSING 4

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1086 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1087 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1088 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
26521 1 F FOUND DEAD 0

Page 1089 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1090 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1091 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1092 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1093 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
26473 10 F SCHEDULED EUTHANASIA 21
Page 1094 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1095 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
26452 15 F SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21

Page 1096 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1097 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1098 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1099 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1100 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1101 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1102 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1103 of 4796

12 M SMALL STATURE 4
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1104 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
26527 3 M SELECTED FOR POST-WEANING BEHAVIORAL TESTING 21
Page 1105 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

2 F FOUND DEAD 0
Page 1106 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1107 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
20 F MISSING 1
Page 1108 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
DAMS FROM GROUP 2: 0.15 PPM PUP # SEX PUP GROSS OBSERVATION POSTNATAL DAY
-----------------------------------------------------------------------------------------------------------------------------------
Page 1109 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1110 of 4796

4 M FOUND DEAD 2
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1111 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1112 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1113 of 4796
15 F FOUND DEAD 2

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1114 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
14 F MISSING 1
Page 1115 of 4796

2 F FOUND DEAD 0
3 M FOUND DEAD 4
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1116 of 4796
13 F BODY PALE 4
BODY COOL 4
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1117 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1118 of 4796


TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1119 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1120 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1121 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1122 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1123 of 4796


TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
6 M MISSING 1
Page 1124 of 4796
8 F BODY PALE 4
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1125 of 4796
4 M SMALL STATURE 4
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1126 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1127 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1128 of 4796


TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1129 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1130 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1131 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1132 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1133 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1134 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1135 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1136 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
26450 5 M SCHEDULED EUTHANASIA 21
Page 1137 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1138 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1139 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1140 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
EXOPHTHALMUS 15
RIGHT EYE
BUPHTHALMOS 15
RIGHT EYE
BUPHTHALMOS 21
RIGHT EYE
EXOPHTHALMUS 21
RIGHT EYE
Page 1141 of 4796
WET RED MATERIAL AROUND RIGHT EYE 20

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1142 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
10 M FOUND DEAD 3
Page 1143 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

2 M FOUND DEAD 0
Page 1144 of 4796
3 F FOUND DEAD 0
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1145 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1146 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
LACERATION 6
FACIAL AREA
SUBCUTANEOUS HEMORRHAGE(S) 6
VENTRAL NECK
VENTRAL THORACIC AREA
Page 1147 of 4796
BODY PALE 6
SCABBING 11
FACIAL AREA
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
PARTIALLY CANNIBALIZED
Page 1148 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1149 of 4796


TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1150 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1151 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1152 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1153 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1154 of 4796
8 M SMALL STATURE 4
10 M FOUND DEAD 3
11 F SMALL STATURE 4
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
16 F FOUND DEAD 4

Page 1155 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1156 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1157 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1158 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1159 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1160 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1161 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

SMALL STATURE 11
FOUND DEAD 13
Page 1162 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
FOUND DEAD 6
Page 1163 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
6 M FOUND DEAD 4
Page 1164 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1165 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1166 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

2 M FOUND DEAD 2
Page 1167 of 4796
FOUND DEAD 8
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1168 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
FOUND DEAD 7
Page 1169 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
SMALL STATURE 11
FOUND DEAD 13
FOUND DEAD 20
BODY PALE 20
GASPING 20
HYPOACTIVITY 20
FOUND DEAD 20
Page 1170 of 4796
26519 1 F GASPING 0
2 M MISSING 2
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1171 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

SMALL STATURE 11
SMALL STATURE 21
Page 1172 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1173 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1174 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1175 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1176 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
26507 1 F GASPING 1
Page 1177 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1178 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1179 of 4796
8 M MISSING 1
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1180 of 4796
SMALL STATURE 11
SMALL STATURE 21
17 F MISSING 1

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1181 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1182 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1183 of 4796


TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1184 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1185 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1186 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1187 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1188 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1189 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1190 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1191 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1192 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1193 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
12 F FOUND DEAD 4
Page 1194 of 4796
23259 1 F SMALL STATURE 0

MISSING 1
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1195 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1196 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1197 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1198 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1199 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1200 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1201 of 4796
19 F MISSING 1

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1202 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1203 of 4796
SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET 4


TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1204 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1205 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
5 M FOUND DEAD 4
Page 1206 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1207 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1208 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
2 M FOUND DEAD 0
3 M GASPING 0
FOUND DEAD 1
4 M GASPING 0
FOUND DEAD 1
5 M GASPING 0
6 F FOUND DEAD 0
7 F FOUND DEAD 0
8 F FOUND DEAD 0
9 F GASPING 0
Page 1209 of 4796
FOUND DEAD 1
10 F FOUND DEAD 1
15 F FOUND DEAD 1

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
3 M MISSING 2
Page 1210 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1211 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1212 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

2 M MISSING 1
Page 1213 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1214 of 4796
17 F LACERATION 4
RIGHT AXILLARY AREA
VENTRAL NECK
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
VENTRAL THORACIC AREA

Page 1215 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1216 of 4796
26533 1 U FOUND DEAD 0

PARTIALLY CANNIBALIZED
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1217 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

2 M FOUND DEAD 0
3 F FOUND DEAD 0
Page 1218 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1219 of 4796
14 F MISSING 3

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1220 of 4796
8 F MISSING 1
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1221 of 4796


TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1222 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1223 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1224 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1225 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1226 of 4796

2 M FOUND DEAD 0
3 F FOUND DEAD 0
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1227 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1228 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1229 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1230 of 4796

2 F FOUND DEAD 0
3 F FOUND DEAD 0
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
6 M MISSING 1
Page 1231 of 4796
12 F FOUND DEAD 1

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1232 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1233 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1234 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1235 of 4796


TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1236 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1237 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1238 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

2 M FOUND DEAD 1
Page 1239 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1240 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1241 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1242 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
9 F MISSING 3
Page 1243 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

2 F FOUND DEAD 0
Page 1244 of 4796
FOUND DEAD 14
REDDENED PLANTAR SURFACE OF LEFT HINDLIMB 14
REDDENED PLANTAR SURFACE OF RIGHT HINDLIMB 14
FOUND DEAD 11
BODY COOL 11
REDDENED PALMAR SURFACE OF RIGHT FORELIMB 11
REDDENED PALMAR SURFACE OF LEFT FORELIMB 11
FOUND DEAD 12
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
FOUND DEAD 12
Page 1245 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1246 of 4796

SMALL STATURE 11
BODY PALE 5
BODY COOL 5
GASPING 5
LABORED RESPIRATION 5
EUTHANIZED IN EXTREMIS 5
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1247 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
26485 10 M SCHEDULED EUTHANASIA; SEX RATIO CRITERIA NOT MET 4

Page 1248 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1249 of 4796


2 M SMALL STATURE 4
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1250 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1251 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1252 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1253 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1254 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1255 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1256 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1257 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
26472 1 F GASPING 0
MISSING 1
2 F SUBCUTANEOUS HEMORRHAGE(S) 1
DORSAL ABDOMINAL AREA
VENTRAL ABDOMINAL AREA
Page 1258 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1259 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1260 of 4796

EYELIDS COMPLETELY SHUT 21
EYELIDS COMPLETELY SHUT 18
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
9 F LACERATION 4
LEFT INGUINAL AREA
LEFT HINDLIMB
SCABBING 11
LEFT INGUINAL AREA
Page 1261 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1262 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
10 F MISSING 2
Page 1263 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1264 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1265 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1266 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1267 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1268 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1269 of 4796

23237 1 M LACERATION 0
VENTRAL ABDOMINAL AREA
SENT TO NECROPSY DUE TO DEATH OF DAM 0
2 M SENT TO NECROPSY DUE TO DEATH OF DAM 0
5 F SENT TO NECROPSY DUE TO DEATH OF DAM 0
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
23237 6 F SENT TO NECROPSY DUE TO DEATH OF DAM 0

Page 1270 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1271 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1272 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1273 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
5 M FOUND DEAD 1
Page 1274 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

4 M MISSING 1
Page 1275 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1276 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1277 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1278 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1279 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

2 M FOUND DEAD 2
3 M FOUND DEAD 1
Page 1280 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
13 M FOUND DEAD 2
Page 1281 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

2 M SMALL STATURE 4
3 M SMALL STATURE 4
Page 1282 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1283 of 4796
FOUND DEAD 5
BODY PALE 4

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1284 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1285 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1286 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1287 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1288 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1289 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1290 of 4796

TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------
Page 1291 of 4796
TABLE A24 (F1)

-----------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------

Page 1292 of 4796

TABLE A24 (F1)

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-----------------------------------------------------------------------------------------------------------------------------------
Page 1293 of 4796

TABLE A24 (F1)

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Page 1294 of 4796
TABLE A24 (F1)

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Page 1295 of 4796

3 M MISSING 1
TABLE A24 (F1)

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Page 1296 of 4796
TABLE A24 (F1)

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15 F MISSING 2

Page 1297 of 4796
TABLE A24 (F1)

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TABLE A24 (F1)

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TABLE A24 (F1)

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Page 1300 of 4796
TABLE A24 (F1)

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Page 1301 of 4796
TABLE A24 (F1)

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Page 1302 of 4796
FOUND DEAD 8
TABLE A24 (F1)

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26462 10 F MISSING 4
Page 1303 of 4796
16 F FOUND DEAD 3

3 M FOUND DEAD 1
TABLE A24 (F1)

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Page 1304 of 4796

TABLE A24 (F1)

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Page 1305 of 4796

TABLE A24 (F1)

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Page 1306 of 4796
TABLE A24 (F1)

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PPOBSv4.06
02/04/2009
Page 1307 of 4796
FINAL REPORT
Volume 5 of 16
STUDY TITLE
STUDY NUMBER
WIL-186056
DATA REQUIREMENT

OECD Guideline 426
STUDY DIRECTOR
26 June 2008
30 September 2009

1407 George Road
SPONSOR

Arlington, VA 22209
Page 1308 of 4796

APPENDIX A
TABLES A25-A32
Page 1309 of 4796

TABLE A25 (F1)
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHTS [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23243-01 M 6.9 9.5 15.4 25.5 33.3 40.5 48.9
23243-02 M 6.7 9.1 16.0 25.7 32.7 41.7 52.6
23243-03 M 6.8 9.5 15.8 26.1 33.5 42.4 50.2
23243-04 M 7.5 10.4 NA NA NA NA NA
23243-05 M 6.8 9.6 15.6 25.6 33.5 40.2 49.1
23243-06 M 6.1 8.6 NA NA NA NA NA
23243-07 M 6.5 8.9 NA NA NA NA NA
23243-08 M 7.0 9.5 NA NA NA NA NA
23243-09 M 6.9 9.8 NA NA NA NA NA
23243-10 F 6.6 9.5 15.6 25.4 33.3 40.7 50.5
Page 1310 of 4796
23243-11 F 6.6 9.1 NA NA NA NA NA

23243-12 F 6.4 9.3 15.7 25.2 33.0 40.6 48.6
23243-13 F 6.3 8.5 NA NA NA NA NA
23243-14 F 6.9 9.3 16.0 26.5 35.2 42.3 50.1
23243-15 F 6.9 8.1 13.5 23.1 31.2 38.9 49.1
MALES MEAN 6.8 9.4 15.7 25.7 33.3 41.2 50.2

FEMALES MEAN 6.6 9.0 15.2 25.1 33.2 40.6 49.6
23213-02 M 7.8 10.3 16.2 26.2 34.7 42.6 53.4

23213-03 M 7.7 10.4 17.2 26.8 35.8 41.9 51.8
23213-04 M 8.1 10.7 16.9 26.9 35.2 43.1 52.7
23213-05 F 6.7 9.4 NA NA NA NA NA
23213-06 F 7.0 9.1 NA NA NA NA NA
23213-07 F 6.8 9.0 NA NA NA NA NA
23213-08 F 7.8 10.8 17.0 26.4 34.8 42.5 53.0
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23213-09 F 6.7 9.1 14.7 23.1 31.7 39.3 48.2
23213-10 F 7.6 10.6 16.6 26.6 35.1 41.5 52.1
23213-11 F 7.3 9.4 NA NA NA NA NA
23213-12 F 7.2 9.2 NA NA NA NA NA
23213-13 F 8.2 10.8 16.8 27.2 36.3 43.4 54.2
23213-14 F 6.6 8.2 NA NA NA NA NA
23213-15 F 7.3 9.7 15.6 24.6 33.1 39.5 49.7
MALES MEAN 7.9 10.5 16.8 26.6 35.2 42.5 52.6

FEMALES MEAN 7.2 9.6 16.1 25.6 34.2 41.2 51.4
Page 1311 of 4796
23203-01 M 6.9 8.6 13.7 23.8 33.1 41.2 54.4

23203-02 M 6.9 9.0 NA NA NA NA NA
23203-03 M 6.9 8.8 NA NA NA NA NA
23203-04 M 6.6 8.8 14.2 23.6 31.0 38.0 51.5
23203-05 M 5.7 6.7 10.5 18.9 25.8 32.3 40.5
23203-06 M 7.1 8.9 NA NA NA NA NA
23203-07 M 6.0 NA NA NA NA NA NA
23203-08 M 8.0 9.6 15.8 25.3 32.9 40.6 51.1
23203-09 F 6.8 9.2 14.9 25.2 34.4 41.2 54.1
23203-10 F 5.7 6.9 NA NA NA NA NA
23203-11 F 6.2 7.4 NA NA NA NA NA
23203-12 F 7.0 8.1 12.7 23.6 30.6 37.7 50.1
23203-13 F 6.6 8.3 13.5 22.0 32.5 40.5 50.4
23203-14 F 6.6 8.3 NA NA NA NA NA
23203-15 F 6.3 7.4 12.8 20.6 29.4 37.6 46.2
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23203-16 F 6.2 7.4 NA NA NA NA NA
23203-17 F 6.9 8.5 NA NA NA NA NA
MALES MEAN 6.8 8.6 13.6 22.9 30.7 38.0 49.4

FEMALES MEAN 6.5 7.9 13.5 22.9 31.7 39.3 50.2
23207-01 M 6.7 8.7 14.5 23.8 31.0 37.3 44.7

23207-02 M 7.1 9.9 16.8 27.1 36.3 45.9 53.5
23207-03 M 7.1 9.1 15.2 24.2 32.6 40.5 47.6
23207-04 M 6.3 8.3 13.6 22.2 30.4 39.2 48.2
Page 1312 of 4796
23207-05 F 6.0 7.6 NA NA NA NA NA

23207-06 F 6.8 9.0 15.0 23.3 30.5 38.6 46.6
23207-07 F 6.5 8.5 NA NA NA NA NA
23207-08 F 6.1 7.8 NA NA NA NA NA
23207-09 F 6.7 9.0 15.5 24.6 32.8 40.8 49.4
23207-10 F 6.6 8.6 8.6 NA NA NA NA
23207-11 F 6.4 8.1 NA NA NA NA NA
23207-12 F 6.8 9.0 NA NA NA NA NA
23207-13 F 6.1 8.0 NA NA NA NA NA
23207-14 F 6.3 8.4 13.6 21.5 28.5 34.7 41.2
MALES MEAN 6.8 9.0 15.0 24.3 32.6 40.7 48.5

FEMALES MEAN 6.4 8.4 13.2 23.1 30.6 38.0 45.7
23226-01 M 6.1 8.0 12.5 21.3 30.9 37.4 47.4

23226-02 M 6.5 8.6 14.1 23.8 31.8 39.0 50.8
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23226-03 M 5.4 6.7 10.5 19.2 28.1 36.0 43.8
23226-04 M 6.4 8.4 13.0 23.1 32.6 41.2 52.5
23226-05 F 5.6 7.6 11.9 20.8 30.1 36.8 45.9
23226-06 F 6.1 7.5 NA NA NA NA NA
23226-07 F 5.3 6.4 NA NA NA NA NA
23226-08 F 5.4 6.5 10.3 18.8 27.7 34.5 41.1
23226-09 F 5.8 7.2 NA NA NA NA NA
23226-10 F 5.9 8.4 12.6 22.3 30.8 38.3 48.7
23226-11 F 5.8 7.2 NA NA NA NA NA
23226-12 F 6.1 7.3 NA NA NA NA NA
Page 1313 of 4796
23226-13 F 6.0 6.9 11.0 19.3 28.6 35.3 44.2

23226-14 F 6.5 NA NA NA NA NA NA
23226-15 F 6.1 7.9 NA NA NA NA NA
MALES MEAN 6.1 7.9 12.5 21.9 30.9 38.4 48.6

FEMALES MEAN 5.9 7.3 11.5 20.3 29.3 36.2 45.0
23242-01 M 6.4 9.0 NA NA NA NA NA

23242-02 M 6.3 8.2 NA NA NA NA NA
23242-03 M 6.4 8.5 NA NA NA NA NA
23242-04 M 6.5 9.0 14.3 23.6 30.6 37.5 49.1
23242-05 M 6.6 9.1 14.9 24.1 32.9 40.3 51.9
23242-06 M 7.1 9.4 15.7 26.2 35.5 43.0 55.9
23242-07 M 6.2 8.2 NA NA NA NA NA
23242-08 M 6.5 8.4 14.3 24.4 33.2 41.8 53.1
23242-09 F 6.1 8.4 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23242-10 F 5.9 8.3 NA NA NA NA NA
23242-11 F 5.9 7.9 13.7 23.1 32.8 40.5 51.6
23242-12 F 6.4 8.5 NA NA NA NA NA
23242-13 F 6.2 8.2 NA NA NA NA NA
23242-14 F 5.8 7.6 NA NA NA NA NA
23242-15 F 6.0 8.2 13.3 22.2 30.8 36.8 47.2
23242-16 F 6.1 8.0 13.7 22.3 30.9 37.4 47.1
23242-17 F 5.3 7.9 13.3 22.3 30.9 38.3 46.9
MALES MEAN 6.5 8.7 14.8 24.6 33.1 40.7 52.5

Page 1314 of 4796
FEMALES MEAN 6.0 8.1 13.5 22.5 31.4 38.3 48.2
23209-01 M 7.3 10.6 NA NA NA NA NA

23209-02 M 6.9 9.8 NA NA NA NA NA
23209-03 M 7.2 10.2 16.9 24.7 32.1 38.3 50.3
23209-04 M 6.9 8.8 NA NA NA NA NA
23209-05 M 7.0 9.9 16.1 23.7 31.3 37.3 47.4
23209-06 M 6.4 8.6 14.4 22.6 31.7 37.1 49.0
23209-07 M 7.2 9.4 NA NA NA NA NA
23209-08 M 7.4 10.1 14.8 24.5 32.8 40.3 52.8
23209-09 M 6.7 9.0 NA NA NA NA NA
23209-10 F 7.0 9.4 NA NA NA NA NA
23209-11 F 6.7 9.7 NA NA NA NA NA
23209-12 F 7.1 10.7 17.1 26.1 35.3 41.2 51.3
23209-13 F 6.5 8.2 NA NA NA NA NA
23209-14 F 6.8 9.3 14.5 22.9 30.3 36.7 48.4
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23209-15 F 7.7 10.8 17.4 26.7 35.1 40.0 52.2
23209-16 F 7.0 9.3 15.7 24.2 32.2 36.7 49.4
MALES MEAN 7.0 9.6 15.6 23.9 32.0 38.3 49.9

FEMALES MEAN 7.0 9.6 16.2 25.0 33.2 38.7 50.3
23178-01 M 6.6 9.8 16.7 25.7 34.7 42.8 57.3

23178-02 M 6.4 8.8 NA NA NA NA NA
23178-03 M 5.6 7.9 13.2 20.8 29.2 34.6 43.4
23178-04 M 6.3 8.8 15.1 24.5 33.0 40.7 52.8
Page 1315 of 4796
23178-05 M 5.3 7.7 NA NA NA NA NA

23178-06 M 6.1 8.5 NA NA NA NA NA
23178-07 M 6.3 9.1 15.4 24.4 31.9 39.6 54.0
23178-08 M 6.2 8.3 NA NA NA NA NA
23178-09 F 5.9 8.5 NA NA NA NA NA
23178-10 F 5.5 7.3 NA NA NA NA NA
23178-11 F 5.3 7.4 12.3 20.3 28.6 35.8 47.2
23178-12 F 5.3 7.4 12.8 20.9 29.4 36.7 44.2
23178-13 F 5.4 7.5 12.7 20.5 26.8 33.2 44.5
23178-14 F 5.8 8.3 14.0 23.1 30.8 37.6 49.0
23178-15 F 5.7 8.2 NA NA NA NA NA
MALES MEAN 6.1 8.6 15.1 23.9 32.2 39.4 51.9

FEMALES MEAN 5.6 7.8 13.0 21.2 28.9 35.8 46.2
23186-01 M 6.7 8.8 15.0 23.4 32.0 38.7 48.8
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23186-02 M 6.1 8.0 13.8 23.9 30.8 37.7 46.2
23186-03 M 5.9 8.0 13.2 22.2 30.8 37.2 44.6
23186-04 M 6.0 8.2 NA NA NA NA NA
23186-05 M 5.6 7.3 12.0 20.1 28.2 35.4 42.8
23186-06 M 6.2 8.4 NA NA NA NA NA
23186-07 F 5.8 7.4 12.2 20.0 27.3 33.0 40.6
23186-08 F 5.4 7.5 12.7 20.9 28.0 35.4 43.3
23186-09 F 5.9 7.5 13.2 21.1 28.9 35.9 44.1
23186-10 F 5.9 7.9 NA NA NA NA NA
23186-11 F 5.8 7.6 13.4 22.4 31.6 38.4 46.0
Page 1316 of 4796
23186-12 F 6.1 8.2 NA NA NA NA NA

23186-13 F 5.5 7.2 NA NA NA NA NA
23186-14 F 6.1 8.3 NA NA NA NA NA
MALES MEAN 6.1 8.1 13.5 22.4 30.5 37.3 45.6

FEMALES MEAN 5.8 7.7 12.9 21.1 29.0 35.7 43.5
23194-01 M 5.9 7.9 12.9 21.3 31.2 39.4 48.4

23194-02 M 6.6 8.6 NA NA NA NA NA
23194-03 M 6.1 6.9 7.1 NA NA NA NA
23194-04 M 6.5 9.0 15.0 24.0 32.4 42.2 51.8
23194-05 M 6.3 8.4 NA NA NA NA NA
23194-06 M 6.6 9.2 15.5 26.3 35.0 43.5 54.1
23194-07 M 5.9 8.1 NA NA NA NA NA
23194-08 M 6.2 8.6 NA NA NA NA NA
23194-09 F 5.7 7.2 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23194-10 F 6.2 7.5 12.9 21.5 29.2 38.0 46.9
23194-11 F 5.9 8.2 NA NA NA NA NA
23194-12 F 5.5 7.2 NA NA NA NA NA
23194-13 F 4.7 6.5 10.7 19.6 28.7 38.3 46.6
23194-14 F 6.0 8.2 NA NA NA NA NA
23194-15 F 6.0 7.9 12.9 22.8 33.2 42.5 53.1
23194-17 F 5.9 8.0 13.1 21.9 30.3 38.6 48.8
MALES MEAN 6.3 8.3 12.6 23.9 32.9 41.7 51.4

Page 1317 of 4796
FEMALES MEAN 5.6 7.6 12.4 21.5 30.4 39.4 48.9
23182-01 M 7.7 9.8 NA NA NA NA NA

23182-02 M 7.6 10.5 NA NA NA NA NA
23182-03 M 7.8 11.1 18.0 30.9 38.1 46.0 57.2
23182-04 M 7.6 9.5 16.2 27.3 35.4 44.4 48.3
23182-05 M 7.4 9.8 16.5 28.8 38.9 47.8 56.1
23182-06 M 7.8 10.4 NA NA NA NA NA
23182-07 M 7.9 10.4 17.4 29.5 37.9 46.1 57.1
23182-08 F 7.1 9.1 NA NA NA NA NA
23182-09 F 7.6 10.3 NA NA NA NA NA
23182-10 F 7.4 9.6 16.5 27.3 37.5 46.5 54.6
23182-11 F 7.0 9.4 15.0 27.4 33.9 41.0 50.1
23182-12 F 6.7 8.4 13.9 24.3 32.2 41.2 49.2
23182-13 F 7.2 9.3 NA NA NA NA NA
23182-14 F 7.2 9.5 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23182-15 F 7.4 9.1 16.0 27.6 35.5 45.4 54.7
23182-16 F 7.0 9.2 NA NA NA NA NA
MALES MEAN 7.7 10.2 17.0 29.1 37.6 46.1 54.7

FEMALES MEAN 7.2 9.3 15.4 26.7 34.8 43.5 52.2
23240-02 M 8.1 11.1 18.4 27.5 35.4 41.7 51.3

23240-03 M 8.2 10.6 NA NA NA NA NA
23240-04 M 8.0 11.4 NA NA NA NA NA
23240-05 M 6.6 8.8 15.6 24.4 32.0 38.1 48.0
Page 1318 of 4796
23240-06 M 7.7 10.3 16.7 26.2 33.5 38.7 48.6

23240-07 M 6.5 8.9 NA NA NA NA NA
23240-08 M 8.0 10.5 17.7 26.9 34.0 41.4 49.6
23240-09 M 8.3 11.4 NA NA NA NA NA
23240-10 M 8.2 10.6 NA NA NA NA NA
23240-11 M 7.9 10.7 NA NA NA NA NA
23240-12 F 7.5 9.4 16.6 25.9 32.3 37.5 45.2
23240-13 F 7.5 10.0 17.2 27.1 34.1 40.7 49.4
23240-14 F 7.5 10.0 16.6 26.1 33.5 40.1 50.3
23240-15 F 7.2 10.3 16.2 26.0 32.9 40.1 48.2
MALES MEAN 7.8 10.4 17.1 26.3 33.7 40.0 49.4

FEMALES MEAN 7.4 9.9 16.7 26.3 33.2 39.6 48.3
26521-02 M 7.4 9.8 16.6 25.9 35.1 43.0 55.2

26521-03 M 7.4 10.2 16.3 26.3 35.5 41.7 56.0
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26521-04 M 6.9 9.8 NA NA NA NA NA
26521-05 M 7.2 10.0 17.1 27.2 36.9 46.3 58.7
26521-06 M 7.1 10.3 NA NA NA NA NA
26521-07 M 7.1 10.6 NA NA NA NA NA
26521-08 M 6.8 9.5 15.7 25.4 35.0 42.2 52.5
26521-09 M 7.4 10.0 NA NA NA NA NA
26521-10 M 6.8 9.3 NA NA NA NA NA
26521-11 F 7.0 9.5 NA NA NA NA NA
26521-12 F 6.5 9.1 15.2 24.8 32.9 39.4 49.9
26521-13 F 7.2 9.8 NA NA NA NA NA
Page 1319 of 4796
26521-14 F 7.2 10.0 17.5 27.2 36.3 43.6 57.4

26521-15 F 6.0 8.1 NA NA NA NA NA
26521-16 F 7.0 9.5 15.5 24.9 34.2 41.4 54.1
26521-17 F 7.2 10.2 16.7 26.1 36.3 43.7 56.0
MALES MEAN 7.1 9.9 16.4 26.2 35.6 43.3 55.6

FEMALES MEAN 6.9 9.5 16.2 25.8 34.9 42.0 54.4
26449-02 M 6.2 8.4 NA NA NA NA NA

26449-03 M 7.4 10.0 NA NA NA NA NA
26449-04 M 7.1 9.3 NA NA NA NA NA
26449-05 M 7.1 9.3 15.1 23.7 31.5 39.9 54.6
26449-06 M 7.1 9.8 NA NA NA NA NA
26449-07 M 7.0 9.2 15.5 23.2 31.8 38.5 56.2
26449-08 M 6.8 9.1 14.9 24.2 32.3 40.9 57.0
26449-09 M 6.5 9.3 15.4 24.6 32.4 41.7 57.5
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26449-10 M 6.9 9.0 NA NA NA NA NA
26449-11 F 6.5 9.2 NA NA NA NA NA
26449-12 F 6.8 9.4 15.2 24.5 33.1 40.9 57.4
26449-13 F 6.8 9.1 NA NA NA NA NA
26449-14 F 6.5 8.9 14.7 24.0 31.6 39.7 53.5
26449-15 F 6.5 9.1 15.1 24.3 31.7 39.8 56.2
26449-16 F 6.8 8.6 NA NA NA NA NA
26449-17 F 6.2 8.7 14.7 24.0 29.6 36.7 50.9
MALES MEAN 6.9 9.3 15.2 23.9 32.0 40.3 56.3

Page 1320 of 4796
FEMALES MEAN 6.6 9.0 14.9 24.2 31.5 39.3 54.5
26473-01 M 7.4 9.7 NA NA NA NA NA

26473-02 M 7.3 9.8 NA NA NA NA NA
26473-03 M 7.0 9.2 15.4 24.7 33.0 41.2 57.7
26473-04 M 7.9 10.5 16.9 26.1 32.6 38.8 56.7
26473-05 M 7.7 10.2 16.4 25.3 32.3 39.0 50.2
26473-06 M 7.8 10.5 16.6 25.9 31.6 37.0 52.6
26473-07 M 8.5 11.4 NA NA NA NA NA
26473-08 F 6.7 8.8 NA NA NA NA NA
26473-09 F 6.7 8.7 14.1 22.6 29.4 35.8 51.2
26473-10 F 7.2 9.8 15.7 24.8 32.3 38.3 51.7
26473-11 F 7.6 9.7 15.5 25.2 32.2 37.7 51.3
26473-12 F 7.4 10.5 NA NA NA NA NA
26473-13 F 7.3 10.1 16.1 25.2 31.9 38.2 54.5
26473-14 F 7.5 10.3 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26473-15 F 7.4 9.8 NA NA NA NA NA
MALES MEAN 7.7 10.2 16.3 25.5 32.4 39.0 54.3

FEMALES MEAN 7.2 9.7 15.4 24.5 31.5 37.5 52.2
26452-02 M 6.5 9.4 14.0 24.3 32.6 39.3 50.3

26452-03 M 6.2 8.2 15.2 22.4 31.2 41.4 54.6
26452-04 M 6.7 8.9 NA NA NA NA NA
26452-05 M 6.3 8.9 14.9 25.2 33.2 42.9 55.2
26452-06 M 7.0 9.3 NA NA NA NA NA
Page 1321 of 4796
26452-07 M 6.8 8.7 NA NA NA NA NA

26452-08 M 7.3 10.0 NA NA NA NA NA
26452-09 M 6.9 9.3 NA NA NA NA NA
26452-10 M 6.1 8.6 NA NA NA NA NA
26452-11 M 6.8 9.6 16.4 26.0 36.1 45.2 59.1
26452-12 F 6.6 9.5 NA NA NA NA NA
26452-13 F 6.1 8.5 14.4 23.6 32.9 43.0 57.0
26452-14 F 6.6 9.2 NA NA NA NA NA
26452-15 F 6.5 8.9 14.7 22.1 33.2 40.7 53.0
26452-16 F 5.8 8.2 13.2 23.8 29.7 37.0 48.6
26452-17 F 5.4 7.9 13.5 21.7 29.9 38.5 48.4
MALES MEAN 6.7 9.1 15.1 24.5 33.3 42.2 54.8

FEMALES MEAN 6.2 8.7 14.0 22.8 31.4 39.8 51.8
26491-01 M 7.5 10.3 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26491-02 M 8.3 11.2 18.0 27.6 33.5 41.0 60.2
26491-03 M 8.0 10.6 17.6 27.8 33.9 41.2 60.5
26491-04 M 7.7 10.1 16.5 25.8 30.5 36.9 51.1
26491-05 M 7.5 10.1 16.1 25.8 30.7 37.4 55.1
26491-06 M 8.5 11.1 NA NA NA NA NA
26491-07 F 7.5 10.0 16.5 25.4 31.3 37.4 50.5
26491-08 F 7.5 10.0 NA NA NA NA NA
26491-09 F 7.3 9.8 16.5 26.0 30.9 37.2 49.8
26491-10 F 7.6 10.5 17.2 26.3 32.2 40.9 60.1
26491-11 F 7.8 10.1 NA NA NA NA NA
Page 1322 of 4796
26491-12 F 7.8 10.0 NA NA NA NA NA

26491-13 F 7.2 9.9 NA NA NA NA NA
26491-14 F 7.6 10.6 18.1 27.8 32.5 39.1 53.9
MALES MEAN 7.9 10.6 17.1 26.8 32.2 39.1 56.7

FEMALES MEAN 7.5 10.1 17.1 26.4 31.7 38.7 53.6
26512-01 M 8.0 10.9 17.7 28.1 36.3 43.4 61.1

26512-02 M 7.9 11.8 17.7 27.8 36.1 43.9 56.5
26512-03 M 8.1 11.3 16.7 26.0 33.0 38.9 50.3
26512-04 F 7.5 10.6 NA NA NA NA NA
26512-05 F 7.4 10.7 16.7 25.8 30.7 40.7 56.9
26512-06 F 6.9 9.6 15.5 24.7 32.4 37.1 50.6
26512-07 F 7.6 10.8 16.6 26.1 33.9 42.8 56.0
26512-08 F 7.6 10.4 NA NA NA NA NA
26512-09 F 6.6 9.5 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26512-10 F 7.2 10.2 NA NA NA NA NA
26512-11 F 7.6 10.7 17.0 24.9 31.1 38.5 53.1
26512-12 F 7.3 9.7 NA NA NA NA NA
26512-13 F 7.2 10.6 16.0 24.4 31.7 38.3 51.4
MALES MEAN 8.0 11.3 17.4 27.3 35.1 42.1 56.0

FEMALES MEAN 7.3 10.3 16.4 25.2 32.0 39.5 53.6
26454-01 M 6.5 8.7 14.9 24.3 31.5 37.1 48.7

26454-02 M 7.2 10.2 16.9 26.8 33.6 38.4 54.1
Page 1323 of 4796
26454-03 M 8.0 11.9 NA NA NA NA NA

26454-04 M 7.5 10.7 17.4 26.9 34.6 40.5 56.7
26454-05 M 7.9 11.7 18.6 29.6 37.5 41.8 54.6
26454-06 F 7.2 10.6 NA NA NA NA NA
26454-07 F 7.6 11.3 NA NA NA NA NA
26454-08 F 6.3 9.2 15.8 25.7 32.1 37.1 53.6
26454-09 F 7.1 10.2 NA NA NA NA NA
26454-10 F 7.9 10.9 NA NA NA NA NA
26454-11 F 7.4 11.5 18.1 28.9 34.4 39.6 56.4
26454-12 F 8.1 11.6 NA NA NA NA NA
26454-13 F 7.2 10.0 NA NA NA NA NA
26454-14 F 6.8 9.9 16.4 25.0 32.9 38.6 54.5
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26454-15 F 7.1 10.5 16.4 25.2 32.0 36.6 51.8
MALES MEAN 7.4 10.6 17.0 26.9 34.3 39.5 53.5

FEMALES MEAN 7.3 10.6 16.7 26.2 32.9 38.0 54.1
26529-01 M 7.9 10.6 18.3 30.9 40.7 48.5 66.4

26529-02 M 7.9 11.1 18.3 29.7 36.8 43.6 59.6
26529-03 M 8.3 11.5 19.3 31.3 40.1 50.1 66.5
26529-04 M 7.3 10.2 17.4 28.7 37.3 46.4 61.4
26529-05 M 7.4 10.4 NA NA NA NA NA
Page 1324 of 4796
26529-06 F 6.5 9.2 NA NA NA NA NA

26529-07 F 6.0 7.7 NA NA NA NA NA
26529-08 F 7.9 10.6 NA NA NA NA NA
26529-09 F 7.6 9.8 NA NA NA NA NA
26529-10 F 6.5 9.2 15.9 25.9 33.6 41.7 54.6
26529-11 F 7.2 10.1 NA NA NA NA NA
26529-12 F 7.3 10.7 18.1 28.8 35.9 43.3 58.2
26529-13 F 7.0 9.3 NA NA NA NA NA
26529-14 F 7.0 9.4 16.5 26.6 33.3 40.7 55.0
26529-15 F 6.7 9.0 NA NA NA NA NA
26529-16 F 6.1 9.2 15.7 26.6 34.6 42.8 56.7
MALES MEAN 7.8 10.8 18.3 30.2 38.7 47.2 63.5

FEMALES MEAN 6.9 9.5 16.6 27.0 34.4 42.1 56.1
26453-01 M 7.4 9.5 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26453-02 M 7.6 9.6 NA NA NA NA NA
26453-03 M 7.9 9.9 NA NA NA NA NA
26453-04 M 7.5 10.2 NA NA NA NA NA
26453-05 M 7.6 9.7 15.8 25.1 34.4 40.7 53.4
26453-06 M 6.9 9.2 NA NA NA NA NA
26453-07 M 6.4 8.6 NA NA NA NA NA
26453-08 M 7.4 9.9 NA NA NA NA NA
26453-09 M 6.6 8.3 13.3 20.7 27.9 32.7 41.2
26453-10 M 7.3 9.7 NA NA NA NA NA
26453-11 M 6.8 8.9 14.5 23.2 32.0 39.3 51.4
Page 1325 of 4796
26453-12 M 5.3 5.9 NA NA NA NA NA

26453-13 M 7.0 8.5 14.2 20.7 29.9 37.9 51.9
26453-14 F 6.7 8.9 15.2 23.8 32.3 39.9 50.7
26453-15 F 7.0 8.8 15.5 24.0 31.7 39.5 51.9
26453-16 F 7.1 9.1 14.6 23.6 32.0 39.6 50.6
26453-17 F 7.3 10.3 17.1 26.1 33.7 40.9 57.0
MALES MEAN 7.1 9.1 14.5 22.4 31.1 37.7 49.5

FEMALES MEAN 7.0 9.3 15.6 24.4 32.4 40.0 52.6
26527-01 M 6.7 9.3 NA NA NA NA NA

26527-02 M 5.9 8.4 NA NA NA NA NA
26527-03 M 6.2 9.4 14.5 24.5 32.7 38.0 48.1
26527-04 M 6.8 9.5 NA NA NA NA NA
26527-05 M 6.9 9.7 16.3 26.4 34.3 41.2 50.4
26527-06 M 6.3 8.6 13.8 23.8 32.2 39.3 47.3
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26527-07 M 6.4 8.9 14.9 24.5 34.4 42.2 53.2
26527-08 M 6.3 8.6 NA NA NA NA NA
26527-09 F 5.8 8.1 NA NA NA NA NA
26527-10 F 6.6 9.1 NA NA NA NA NA
26527-11 F 5.9 8.2 13.5 23.2 31.2 38.0 47.1
26527-12 F 6.2 8.7 14.3 24.0 32.8 41.1 51.2
26527-13 F 6.2 8.4 14.0 23.6 31.8 39.0 46.5
26527-14 F 5.7 8.2 13.2 22.4 30.6 35.7 44.7
MALES MEAN 6.4 9.1 14.9 24.8 33.4 40.2 49.8

Page 1326 of 4796
FEMALES MEAN 6.1 8.5 13.8 23.3 31.6 38.5 47.4
26489-03 M 6.8 8.9 NA NA NA NA NA

26489-04 M 6.8 8.4 NA NA NA NA NA
26489-05 M 7.0 8.8 NA NA NA NA NA
26489-06 M 6.2 7.8 NA NA NA NA NA
26489-07 M 6.8 8.7 14.8 25.9 34.4 42.7 50.4
26489-08 M 6.2 7.8 12.3 22.7 29.6 36.8 45.6
26489-09 M 6.5 7.9 12.3 22.1 28.9 36.4 42.3
26489-10 M 7.0 9.5 NA NA NA NA NA
26489-11 M 6.6 8.7 13.9 26.2 33.9 41.2 49.9
26489-12 F 6.1 8.3 NA NA NA NA NA
26489-13 F 6.2 8.1 12.4 23.4 30.6 37.8 44.8
26489-14 F 6.1 8.0 NA NA NA NA NA
26489-15 F 7.1 8.6 14.4 25.9 34.7 43.1 49.5
26489-16 F 6.3 7.8 13.2 22.8 31.9 39.6 48.0
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26489-17 F 5.5 6.9 10.7 20.3 26.9 33.5 40.0
26489-18 F 6.1 7.8 NA NA NA NA NA
26489-19 F 5.8 6.3 NA NA NA NA NA
MALES MEAN 6.7 8.5 13.3 24.2 31.7 39.3 47.1

FEMALES MEAN 6.2 7.7 12.7 23.1 31.0 38.5 45.6
MALES MEAN 7.0 9.5 15.4 25.1 33.2 40.6 52.3

S.D. 0.64 0.96 1.60 2.09 2.09 2.50 3.96
Page 1327 of 4796
S.E. 0.13 0.20 0.33 0.44 0.44 0.52 0.83

N 23 23 23 23 23 23 23
FEMALES MEAN 6.6 8.9 14.7 24.1 32.0 39.1 50.2

S.D. 0.61 0.96 1.66 1.97 1.72 1.94 3.53
S.E. 0.13 0.20 0.35 0.41 0.36 0.40 0.74
N 23 23 23 23 23 23 23
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23195-01 M 9.0 11.8 17.6 29.3 38.0 45.1 61.6
23195-02 M 8.2 10.6 NA NA NA NA NA
23195-03 M 8.4 10.5 NA NA NA NA NA
23195-04 M 8.3 11.0 16.6 27.8 37.0 45.2 61.3
23195-05 M 8.9 11.6 17.8 29.5 38.8 48.1 61.3
23195-06 M 9.0 12.1 18.1 29.2 37.4 43.8 58.6
23195-07 M 8.8 11.9 NA NA NA NA NA
23195-08 M 8.1 10.7 17.3 27.1 35.9 42.3 53.2
23195-09 M 8.2 10.8 NA NA NA NA NA
23195-10 F 8.3 11.1 17.8 28.7 36.6 43.2 57.1
Page 1328 of 4796
23195-11 F 8.0 10.7 16.6 27.0 36.0 43.6 56.9

23195-12 F 8.7 11.2 16.7 27.8 36.8 43.5 56.0
MALES MEAN 8.5 11.2 17.5 28.6 37.4 44.9 59.2

FEMALES MEAN 8.3 11.0 17.0 27.8 36.5 43.4 56.7
23180-01 M 6.6 8.3 NA NA NA NA NA

23180-02 M 6.8 9.0 15.8 25.4 33.6 41.7 55.5
23180-03 M 7.0 8.6 14.5 22.3 27.3 32.3 45.1
23180-05 M 6.6 8.0 NA NA NA NA NA
23180-06 M 7.2 10.0 16.3 25.1 32.9 40.8 53.9
23180-07 M 7.5 9.6 15.6 25.6 34.1 42.2 56.2
23180-08 M 6.8 8.8 NA NA NA NA NA
23180-09 F 7.2 9.6 NA NA NA NA NA
23180-10 F 6.6 8.8 15.0 23.9 33.0 38.3 51.1
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23180-11 F 6.3 8.6 15.1 22.3 30.5 36.5 48.6
23180-12 F 6.8 8.8 15.4 25.3 32.0 40.2 54.9
23180-13 F 6.8 8.4 NA NA NA NA NA
23180-14 F 6.7 8.2 NA NA NA NA NA
23180-15 F 7.3 9.3 15.5 24.4 33.3 39.8 52.5
23180-16 F 7.2 9.1 NA NA NA NA NA
MALES MEAN 6.7 8.9 15.6 24.6 32.0 39.3 52.7

FEMALES MEAN 6.9 8.9 15.3 24.0 32.2 38.7 51.8
Page 1329 of 4796
23176-01 M 6.9 8.7 13.2 24.3 33.7 41.4 51.8

23176-02 M 6.4 7.9 11.7 22.4 31.1 34.2 46.4
23176-03 M 6.3 7.6 11.2 20.5 29.6 38.1 46.0
23176-04 M 6.4 8.2 NA NA NA NA NA
23176-05 M 6.5 7.9 NA NA NA NA NA
23176-06 M 6.9 9.1 13.6 24.8 34.6 42.8 51.5
23176-07 M 6.4 8.1 NA NA NA NA NA
23176-08 M 6.6 8.7 NA NA NA NA NA
23176-09 M 6.1 7.1 NA NA NA NA NA
23176-10 F 6.5 8.3 12.9 23.0 32.2 39.1 47.3
23176-11 F 6.0 7.4 NA NA NA NA NA
23176-12 F 5.6 7.0 10.4 20.1 28.3 34.6 42.2
23176-13 F 5.4 6.7 10.3 19.9 29.2 37.1 45.3
23176-14 F 5.9 7.4 11.3 20.9 30.1 37.8 45.3
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23176-16 F 6.5 7.6 NA NA NA NA NA
MALES MEAN 6.5 8.1 12.4 23.0 32.3 39.1 48.9

FEMALES MEAN 5.8 7.4 11.2 21.0 30.0 37.2 45.0
23251-01 M 7.2 10.5 15.9 25.6 34.7 43.4 54.5

23251-02 M 6.9 9.4 15.5 26.2 33.6 42.9 55.0
23251-03 M 8.0 11.2 NA NA NA NA NA
23251-04 M 7.5 10.5 NA NA NA NA NA
23251-05 M 7.9 11.1 18.5 27.4 36.3 44.1 58.5
Page 1330 of 4796
23251-06 M 7.2 10.1 NA NA NA NA NA

23251-07 M 7.5 11.7 NA NA NA NA NA
23251-08 M 7.8 11.2 NA NA NA NA NA
23251-09 M 6.8 10.0 NA NA NA NA NA
23251-10 M 7.6 11.1 18.0 27.7 36.7 45.4 59.9
23251-11 F 7.1 9.8 16.5 26.2 35.2 43.8 56.5
23251-12 F 7.6 10.3 17.4 28.1 38.5 47.4 58.3
23251-13 F 7.4 11.1 18.4 27.8 35.6 42.4 55.0
23251-15 F 7.6 10.6 17.1 27.1 37.0 45.8 58.1
MALES MEAN 7.4 10.7 17.0 26.7 35.3 44.0 57.0

FEMALES MEAN 7.4 10.5 17.4 27.3 36.6 44.9 57.0
23235-04 M 6.2 7.7 12.3 20.5 27.8 34.5 42.4
23235-05 M 5.9 7.4 11.3 18.7 24.7 30.2 37.9
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23235-06 M 6.5 8.5 12.7 19.3 24.9 30.4 34.8
23235-07 F 6.1 8.2 13.9 18.2 29.4 35.6 43.2
23235-08 M 6.1 7.7 11.4 22.1 25.4 31.0 36.3
23235-09 F 6.2 8.1 12.8 20.6 27.7 34.1 43.3
23235-10 F 6.0 8.3 13.9 22.4 28.9 33.9 42.4
23235-11 F 6.6 8.7 NA NA NA NA NA
23235-12 F 6.2 8.8 NA NA NA NA NA
23235-13 F 6.7 7.1 NA NA NA NA NA
23235-14 F 6.2 8.3 13.2 21.3 28.3 33.9 43.9
23235-15 F 6.5 8.2 NA NA NA NA NA
Page 1331 of 4796
MALES MEAN 6.2 7.8 11.9 20.2 25.7 31.5 37.9

FEMALES MEAN 6.3 8.2 13.5 20.6 28.6 34.4 43.2
23231-01 M 7.2 10.8 NA NA NA NA NA

23231-02 M 7.2 9.7 NA NA NA NA NA
23231-03 M 7.3 10.4 16.8 26.5 33.2 39.9 50.3
23231-04 M 7.1 9.6 16.2 25.8 34.5 41.4 52.5
23231-05 M 6.6 9.8 NA NA NA NA NA
23231-06 M 6.4 9.1 15.1 25.0 33.0 41.2 52.3
23231-07 M 6.3 9.3 15.4 25.8 33.8 42.1 52.4
23231-08 M 7.5 10.2 NA NA NA NA NA
23231-09 M 7.0 9.4 NA NA NA NA NA
23231-10 F 6.7 9.3 15.5 25.5 33.5 40.3 51.7
23231-11 F 6.1 8.6 14.7 25.2 33.5 40.3 50.2
23231-12 F 6.5 9.4 15.5 25.5 33.2 40.3 50.8
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23231-13 F 6.6 9.1 14.8 25.6 34.2 41.4 53.8
MALES MEAN 7.0 9.8 15.9 25.8 33.6 41.2 51.9

FEMALES MEAN 6.5 9.1 15.1 25.5 33.6 40.6 51.6
23216-02 M 7.1 10.2 15.0 23.0 32.1 41.4 52.7

23216-03 M 8.3 11.7 18.5 28.7 38.7 47.8 58.1
23216-04 M 7.9 11.1 NA NA NA NA NA
23216-05 M 8.0 11.7 18.5 28.2 37.7 45.3 59.4
23216-06 M 7.6 10.3 NA NA NA NA NA
Page 1332 of 4796
23216-07 M 7.5 11.1 NA NA NA NA NA

23216-08 M 8.1 10.4 16.7 27.2 37.9 46.9 61.8
23216-09 M 7.4 10.1 NA NA NA NA NA
23216-10 M 7.5 10.8 NA NA NA NA NA
23216-11 F 7.0 9.6 15.8 24.9 34.4 40.2 53.2
23216-12 F 7.2 10.3 NA NA NA NA NA
23216-13 F 7.0 9.6 NA NA NA NA NA
23216-14 F 6.8 10.0 NA NA NA NA NA
23216-15 F 7.4 10.4 16.7 25.4 37.3 46.6 61.7
23216-16 F 7.3 10.8 16.4 25.7 35.7 43.6 55.1
23216-17 F 8.2 10.5 15.9 26.6 36.6 46.0 60.4
MALES MEAN 7.7 10.8 17.2 26.8 36.6 45.4 58.0

FEMALES MEAN 7.3 10.2 16.2 25.7 36.0 44.1 57.6
23261-01 M 7.7 10.4 16.6 27.2 36.5 46.5 61.0
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23261-02 M 7.2 10.1 16.6 25.6 33.8 41.5 52.2
23261-03 M 7.5 9.9 NA NA NA NA NA
23261-04 M 7.8 10.4 16.6 25.0 32.0 38.1 52.6
23261-05 M 7.3 10.4 16.8 26.4 34.2 42.0 52.5
23261-06 M 7.3 9.9 NA NA NA NA NA
23261-07 F 7.2 8.9 14.8 23.6 31.9 38.7 49.4
23261-08 F 7.3 10.0 NA NA NA NA NA
23261-09 F 6.8 9.0 15.7 25.8 34.5 42.6 52.0
23261-10 F 7.3 9.3 16.1 24.1 31.5 37.6 44.2
23261-11 F 6.6 8.5 NA NA NA NA NA
Page 1333 of 4796
23261-12 F 7.0 9.8 16.1 25.0 33.7 41.9 55.3

23261-13 F 6.9 9.3 NA NA NA NA NA
MALES MEAN 7.5 10.2 16.7 26.1 34.1 42.0 54.6

FEMALES MEAN 7.0 9.3 15.7 24.6 32.9 40.2 50.2
23205-01 M 8.0 10.0 16.8 25.8 35.8 44.2 59.2

23205-02 M 7.9 10.2 17.2 24.7 34.5 43.8 59.1
23205-03 M 8.8 11.0 NA NA NA NA NA
23205-04 M 7.7 9.9 16.6 24.8 33.7 42.1 57.9
23205-05 M 8.5 11.7 20.4 29.3 39.1 50.1 65.1
23205-06 M 7.8 9.9 NA NA NA NA NA
23205-07 F 8.2 10.7 17.4 25.8 35.7 44.5 60.1
23205-08 F 7.1 9.3 NA NA NA NA NA
23205-09 F 8.0 10.2 NA NA NA NA NA
23205-10 F 7.8 10.1 16.8 25.0 33.9 42.9 57.2
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23205-11 F 7.6 9.7 NA NA NA NA NA
23205-12 F 7.2 9.0 NA NA NA NA NA
23205-13 F 7.3 9.4 NA NA NA NA NA
23205-14 F 6.5 8.0 12.5 19.6 28.1 34.5 48.4
23205-15 F 7.4 9.8 NA NA NA NA NA
23205-16 F 7.6 9.7 16.3 23.8 34.4 43.3 58.0
MALES MEAN 8.1 10.5 17.8 26.2 35.8 45.1 60.3

FEMALES MEAN 7.5 9.6 15.8 23.6 33.0 41.3 55.9
Page 1334 of 4796
23181-01 M 7.8 10.6 NA NA NA NA NA

23181-02 M 8.4 11.1 NA NA NA NA NA
23181-03 M 8.2 11.1 17.3 29.2 34.4 43.2 56.0
23181-04 M 7.9 10.6 16.2 27.9 35.5 42.6 53.7
23181-05 M 8.1 10.5 17.2 28.6 36.7 45.9 58.3
23181-07 M 8.4 11.7 18.2 31.4 38.9 43.9 56.1
23181-08 F 8.3 10.3 14.8 25.0 31.0 37.4 46.1
23181-09 F 7.6 10.5 NA NA NA NA NA
23181-10 F 7.7 9.7 NA NA NA NA NA
23181-11 F 7.5 10.0 15.7 25.8 33.9 43.1 52.7
23181-12 F 7.4 9.8 16.1 27.8 34.1 38.9 48.3
23181-13 F 8.3 10.7 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23181-14 F 7.9 10.0 16.7 28.5 35.6 42.4 52.8
MALES MEAN 8.1 10.9 17.2 29.3 36.4 43.9 56.0

FEMALES MEAN 7.8 10.1 15.8 26.8 33.7 40.5 50.0
23264-02 M 6.3 9.5 15.4 23.9 31.9 38.6 45.5

23264-03 M 5.9 8.5 13.7 22.4 30.4 36.9 45.0
23264-04 M 4.9 6.6 10.7 18.4 25.9 33.0 40.2
23264-05 M 7.1 10.2 15.6 24.0 32.0 40.7 49.6
23264-06 M 6.7 9.5 NA NA NA NA NA
Page 1335 of 4796
23264-07 F 6.0 8.8 14.3 22.8 30.6 36.8 44.5

23264-08 F 5.8 8.2 NA NA NA NA NA
23264-09 F 6.4 8.6 NA NA NA NA NA
23264-10 F 6.3 8.9 15.4 23.2 30.7 38.8 47.2
23264-11 F 5.5 7.6 12.2 20.5 27.6 33.2 39.9
23264-12 F 6.0 8.1 NA NA NA NA NA
23264-13 F 6.1 8.9 15.0 22.5 29.6 34.2 43.9
23264-14 F 5.9 8.4 NA NA NA NA NA
MALES MEAN 6.2 8.9 13.9 22.2 30.1 37.3 45.1

FEMALES MEAN 6.0 8.4 14.2 22.3 29.6 35.8 43.9
26474-02 M 8.2 10.9 16.9 26.4 35.8 44.0 57.2

26474-03 M 7.5 10.0 17.2 26.4 33.6 39.5 54.6
26474-04 M 7.2 9.5 NA NA NA NA NA
26474-05 M 7.7 10.8 17.7 27.1 34.4 41.2 58.5
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26474-06 M 8.1 10.6 NA NA NA NA NA
26474-07 M 8.3 10.8 NA NA NA NA NA
26474-08 M 7.1 9.5 15.5 24.3 32.0 40.0 52.2
26474-09 F 7.2 9.1 NA NA NA NA NA
26474-10 F 6.9 9.6 NA NA NA NA NA
26474-11 F 7.8 10.4 NA NA NA NA NA
26474-12 F 6.9 9.4 15.2 25.1 34.3 41.4 52.0
26474-13 F 5.5 7.5 12.4 20.4 27.1 34.4 44.5
26474-14 F 7.0 8.7 15.2 23.2 29.9 35.8 49.2
26474-15 F 7.1 9.5 NA NA NA NA NA
Page 1336 of 4796
26474-16 F 7.3 9.7 NA NA NA NA NA

26474-17 F 6.7 9.0 13.9 22.5 30.2 37.4 48.8
MALES MEAN 7.7 10.3 16.8 26.1 34.0 41.2 55.6

FEMALES MEAN 6.9 9.2 14.2 22.8 30.4 37.3 48.6
26476-02 M 7.6 10.6 NA NA NA NA NA

26476-03 M 7.9 11.4 19.1 30.2 38.3 48.1 68.7
26476-04 M 7.1 10.3 NA NA NA NA NA
26476-05 M 6.9 10.1 16.8 26.6 34.5 41.3 59.4
26476-06 M 6.4 8.6 14.9 24.5 32.0 40.0 54.4
26476-07 M 8.0 11.4 NA NA NA NA NA
26476-08 M 7.0 10.5 17.4 28.1 36.2 43.0 60.3
26476-09 F 6.1 9.1 15.3 25.1 31.5 36.5 51.4
26476-10 F 7.2 10.0 NA NA NA NA NA
26476-11 F 5.9 8.7 15.3 25.6 33.0 39.9 54.4
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26476-12 F 7.1 10.2 NA NA NA NA NA
26476-13 F 7.0 9.9 16.9 26.7 35.5 43.0 60.0
26476-14 F 7.0 10.1 NA NA NA NA NA
26476-15 F 6.9 10.1 NA NA NA NA NA
26476-16 F 7.1 9.5 16.2 25.9 33.6 39.7 56.7
MALES MEAN 7.3 10.4 17.1 27.4 35.3 43.1 60.7

FEMALES MEAN 6.8 9.7 15.9 25.8 33.4 39.8 55.6
26496-01 M 7.9 11.4 18.0 27.3 36.0 44.3 57.7

Page 1337 of 4796
26496-02 M 8.1 11.2 17.4 26.4 33.6 41.3 58.3

26496-03 M 7.9 10.9 17.8 27.6 35.1 44.3 59.9
26496-04 M 7.7 10.5 NA NA NA NA NA
26496-05 M 8.2 11.2 18.7 28.5 35.4 45.3 59.5
26496-06 F 7.5 10.4 17.4 27.1 34.1 41.8 57.4
26496-07 F 7.5 11.0 17.6 27.0 35.1 42.7 58.8
26496-08 F 7.5 10.6 17.2 26.2 34.5 42.3 57.3
26496-09 F 7.3 10.5 NA NA NA NA NA
26496-10 F 7.2 10.3 17.0 26.8 35.1 43.1 56.5
26496-11 F 7.5 10.4 NA NA NA NA NA
26496-12 F 7.9 10.5 NA NA NA NA NA
MALES MEAN 8.0 11.0 18.0 27.5 35.0 43.8 58.9

FEMALES MEAN 7.5 10.5 17.3 26.8 34.7 42.5 57.5
26505-01 M 6.9 10.1 16.2 25.0 31.6 39.7 55.4
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26505-02 M 7.2 9.9 NA NA NA NA NA
26505-03 M 7.3 9.9 NA NA NA NA NA
26505-04 M 7.8 11.4 17.9 27.6 35.4 43.1 61.9
26505-05 M 7.6 10.9 17.1 27.1 35.0 43.6 59.0
26505-06 M 6.9 9.8 NA NA NA NA NA
26505-07 M 7.5 11.7 18.8 29.4 37.9 48.5 65.0
26505-08 M 6.9 10.3 NA NA NA NA NA
26505-09 F 7.0 10.0 16.3 25.3 31.3 40.5 53.5
26505-10 F 7.1 10.2 16.6 25.6 32.6 40.5 52.7
26505-11 F 5.9 8.5 13.7 21.5 28.9 35.7 46.4
Page 1338 of 4796
26505-12 F 7.4 12.1 18.8 27.1 33.1 40.0 54.3
MALES MEAN 7.3 10.5 17.5 27.3 35.0 43.7 60.3

FEMALES MEAN 6.9 10.2 16.4 24.9 31.5 39.2 51.7
26483-01 M 7.0 10.7 17.7 24.2 29.0 38.3 51.7

26483-02 M 6.7 9.6 16.5 28.2 34.8 43.5 57.7
26483-03 M 7.3 10.6 NA NA NA NA NA
26483-04 M 7.8 11.3 17.5 28.0 35.4 42.7 58.5
26483-05 M 7.0 10.5 NA NA NA NA NA
26483-06 M 7.5 10.8 NA NA NA NA NA
26483-07 M 7.2 10.5 NA NA NA NA NA
26483-08 M 7.3 10.6 18.0 29.9 38.2 45.7 60.0
26483-09 F 7.0 9.9 16.3 27.3 34.4 41.6 53.7
26483-10 F 6.9 9.8 NA NA NA NA NA
26483-11 F 7.1 10.5 17.9 29.8 38.2 45.5 59.2
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26483-12 F 7.0 10.2 17.0 28.4 36.2 43.9 56.8
26483-13 F 6.8 9.6 16.6 27.5 34.5 42.0 53.1
26483-14 F 7.3 11.2 NA NA NA NA NA
MALES MEAN 7.2 10.6 17.4 27.6 34.4 42.6 57.0

FEMALES MEAN 7.0 10.2 17.0 28.3 35.8 43.3 55.7
26479-01 M 6.9 9.3 13.3 22.6 29.7 37.3 50.3

26479-02 M 7.1 9.6 15.4 24.8 31.7 39.0 52.6
26479-03 M 6.7 9.5 14.6 24.7 32.0 39.0 50.3
Page 1339 of 4796
26479-04 M 6.7 9.6 NA NA NA NA NA

26479-05 M 7.1 10.0 15.9 25.8 33.8 42.1 54.4
26479-06 F 6.2 7.7 11.9 19.7 26.3 34.0 42.9
26479-07 F 7.0 9.8 14.3 23.0 29.8 36.0 47.5
26479-08 F 6.1 8.6 NA NA NA NA NA
26479-09 F 7.3 10.0 NA NA NA NA NA
26479-10 F 6.6 9.5 14.0 22.6 30.0 38.1 48.1
26479-11 F 6.4 8.8 NA NA NA NA NA
26479-12 F 7.0 9.5 14.8 23.4 31.3 38.9 51.7
26479-13 F 5.9 8.2 NA NA NA NA NA
26479-14 F 6.4 8.9 NA NA NA NA NA
MALES MEAN 6.9 9.6 14.8 24.5 31.8 39.4 51.9

FEMALES MEAN 6.5 9.0 13.8 22.2 29.4 36.8 47.6
26450-01 M 6.2 8.9 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26450-02 M 5.7 8.2 14.1 22.8 29.7 37.3 50.1
26450-03 M 7.8 10.5 NA NA NA NA NA
26450-04 M 5.8 10.3 NA NA NA NA NA
26450-05 M 7.3 8.0 13.8 23.0 30.6 39.3 47.4
26450-06 M 5.8 8.4 14.6 25.2 33.2 41.2 54.0
26450-07 M 6.7 9.7 NA NA NA NA NA
26450-08 M 6.7 9.5 16.3 26.6 35.7 45.1 53.4
26450-09 M 7.3 10.6 NA NA NA NA NA
26450-10 F 7.0 10.2 NA NA NA NA NA
26450-11 F 6.0 8.3 NA NA NA NA NA
Page 1340 of 4796
26450-12 F 7.1 10.2 NA NA NA NA NA

26450-13 F 6.4 9.3 NA NA NA NA NA
26450-14 F 6.4 9.5 NA NA NA NA NA
26450-15 F 5.6 7.5 13.1 22.6 30.8 37.7 48.8
26450-16 F 6.6 8.7 15.3 25.7 32.9 41.3 52.8
26450-17 F 6.3 8.6 15.0 24.8 32.6 41.1 54.1
26450-18 F 6.8 9.6 16.8 26.5 36.3 45.7 58.6
MALES MEAN 6.6 9.3 14.7 24.4 32.3 40.7 51.2

FEMALES MEAN 6.5 9.1 15.1 24.9 33.2 41.5 53.6
26457-01 M 6.5 8.7 NA NA NA NA NA

26457-02 M 6.4 8.0 NA NA NA NA NA
26457-03 M 6.6 8.0 14.8 25.1 33.3 43.7 55.5
26457-04 M 7.0 8.7 15.0 25.1 32.6 39.6 52.4
26457-05 M 6.6 8.9 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26457-06 M 6.7 9.2 NA NA NA NA NA
26457-07 M 6.6 8.8 NA NA NA NA NA
26457-08 M 6.6 8.6 NA NA NA NA NA
26457-09 M 6.7 8.1 14.4 24.7 32.8 41.6 50.8
26457-10 F 6.3 7.8 NA NA NA NA NA
26457-11 F 5.2 6.5 11.2 20.0 27.7 35.9 45.2
26457-12 F 5.8 7.1 12.0 21.2 29.1 37.5 48.1
26457-13 F 5.8 7.4 NA NA NA NA NA
26457-14 F 5.9 7.7 12.7 21.9 29.9 39.0 50.0
26457-15 F 6.1 7.4 12.4 21.7 28.8 34.8 45.8
Page 1341 of 4796
26457-16 M 6.6 8.5 14.7 24.7 33.4 42.7 52.7

26457-17 F 5.6 7.5 NA NA NA NA NA
MALES MEAN 6.6 8.6 14.7 24.9 33.0 41.9 52.9

FEMALES MEAN 5.8 7.3 12.1 21.2 28.9 36.8 47.3
26492-01 M 6.5 8.6 NA NA NA NA NA

26492-02 M 5.0 6.6 NA NA NA NA NA
26492-03 M 5.7 7.6 12.8 22.4 26.4 32.5 40.8
26492-04 M 6.2 8.3 NA NA NA NA NA
26492-05 M 5.8 7.4 NA NA NA NA NA
26492-06 M 6.3 7.7 12.9 21.6 29.6 38.1 47.6
26492-07 M 6.3 8.7 14.8 24.4 33.0 42.8 54.1
26492-08 M 6.3 8.3 NA NA NA NA NA
26492-09 M 5.8 7.2 NA NA NA NA NA
26492-10 F 6.5 8.9 15.7 25.3 33.1 40.6 47.8
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26492-11 F 5.7 8.0 NA NA NA NA NA
26492-12 F 6.0 7.8 12.2 21.7 28.9 35.9 48.4
26492-13 F 5.9 8.1 13.8 23.0 29.9 39.7 51.1
26492-14 F 6.2 7.7 13.3 22.6 30.1 39.9 50.5
26492-15 F 6.3 8.5 NA NA NA NA NA
26492-16 F 6.0 8.1 NA NA NA NA NA
26492-17 M 5.8 7.8 12.9 22.2 29.2 37.6 47.0
MALES MEAN 6.0 7.8 13.4 22.7 29.6 37.8 47.4

FEMALES MEAN 6.1 8.2 13.8 23.2 30.5 39.0 49.5
Page 1342 of 4796
26493-02 M 6.8 9.0 NA NA NA NA NA
26493-03 M 6.9 8.8 NA NA NA NA NA
26493-04 M 6.2 8.1 12.6 20.5 27.6 33.5 45.2
26493-05 M 7.1 10.5 NA NA NA NA NA
26493-06 M 6.7 8.3 14.9 24.0 33.7 40.6 55.4
26493-07 M 7.2 10.7 17.4 26.6 36.2 43.5 60.5
26493-08 M 6.7 8.2 NA NA NA NA NA
26493-09 M 6.5 8.1 NA NA NA NA NA
26493-11 M 7.0 9.3 13.9 23.4 32.9 40.7 56.5
26493-12 M 7.8 10.4 NA NA NA NA NA
26493-13 F 5.9 8.0 NA NA NA NA NA
26493-14 F 6.3 8.4 13.6 21.6 29.7 37.4 49.0
26493-15 F 6.6 7.9 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26493-16 F 6.0 8.8 14.6 24.3 32.6 41.1 57.6
26493-17 F 6.5 9.4 NA NA NA NA NA
26493-18 F 5.9 7.8 13.0 21.6 29.4 37.1 50.5
26493-19 F 6.1 7.3 NA NA NA NA NA
26493-20 F 5.7 7.3 11.4 19.2 27.2 34.9 44.8
26493-21 F 6.1 7.8 NA NA NA NA NA
MALES MEAN 6.8 9.1 14.7 23.6 32.6 39.6 54.4

FEMALES MEAN 6.1 8.1 13.2 21.7 29.7 37.6 50.5
Page 1343 of 4796
26488-04 M 7.8 11.9 NA NA NA NA NA

26488-05 M 7.8 12.0 19.5 31.7 39.0 45.9 61.6
26488-06 M 7.4 11.9 19.6 31.1 39.2 47.2 60.1
26488-07 M 8.0 12.5 20.5 32.6 38.6 46.1 62.5
26488-08 M 8.1 12.5 20.5 32.2 40.2 49.0 62.3
26488-09 F 7.0 11.2 18.9 30.1 39.2 46.0 58.8
26488-10 F 7.2 11.3 NA NA NA NA NA
26488-11 F 7.3 11.6 19.2 31.3 39.4 47.5 58.8
26488-12 F 8.4 12.8 20.6 32.4 40.6 48.6 60.7
26488-13 F 7.2 11.4 NA NA NA NA NA
26488-14 F 6.9 11.1 18.4 30.7 37.3 44.6 57.1
MALES MEAN 7.8 12.2 20.0 31.9 39.3 47.1 61.6

FEMALES MEAN 7.3 11.6 19.3 31.1 39.1 46.7 58.9
26520-01 M 7.4 8.9 15.9 25.9 32.2 39.8 53.3
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26520-02 M 7.7 9.6 16.8 27.4 36.3 45.5 59.5
26520-03 M 7.2 8.6 14.7 25.0 34.1 42.8 55.4
26520-04 M 7.2 8.8 14.9 25.1 33.7 42.4 55.6
26520-05 F 6.5 8.5 14.9 24.9 32.6 41.3 50.5
26520-06 F 6.2 8.2 NA NA NA NA NA
26520-07 F 6.7 7.9 NA NA NA NA NA
26520-08 F 6.9 8.8 15.4 25.9 33.6 41.5 51.4
26520-09 F 6.5 8.1 NA NA NA NA NA
26520-10 F 6.8 8.5 NA NA NA NA NA
26520-11 F 7.3 8.6 15.4 26.2 34.6 41.5 56.4
Page 1344 of 4796
26520-12 F 7.0 9.2 NA NA NA NA NA

26520-13 F 6.4 8.6 10.7 17.2 25.3 32.2 41.5
26520-14 F 7.4 9.4 NA NA NA NA NA
26520-15 F 6.4 8.3 NA NA NA NA NA
26520-16 F 7.0 9.1 NA NA NA NA NA
MALES MEAN 7.4 9.0 15.6 25.9 34.1 42.6 56.0

FEMALES MEAN 6.8 8.6 14.1 23.6 31.5 39.1 50.0
MALES MEAN 7.2 9.8 16.0 25.8 33.7 41.6 54.3

S.D. 0.68 1.17 1.95 2.55 2.86 3.36 5.65
S.E. 0.14 0.24 0.41 0.53 0.60 0.70 1.18
N 23 23 23 23 23 23 23
FEMALES MEAN 6.8 9.3 15.2 24.6 32.6 40.0 51.7

S.D. 0.65 1.12 1.86 2.65 2.85 3.12 4.59
S.E. 0.14 0.23 0.39 0.55 0.59 0.65 0.96
N 23 23 23 23 23 23 23
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23248-02 M 7.4 9.9 NA NA NA NA NA
23248-03 M 7.6 10.4 NA NA NA NA NA
23248-04 M 7.4 10.0 NA NA NA NA NA
23248-05 M 7.9 11.4 18.3 27.6 34.2 41.6 49.7
23248-06 M 7.2 10.6 17.3 27.9 35.9 46.1 53.5
23248-07 M 7.6 9.6 NA NA NA NA NA
23248-08 M 6.9 9.6 15.3 23.9 31.9 40.6 49.2
23248-09 M 8.0 10.4 17.9 26.2 33.7 41.4 49.6
23248-10 F 6.5 8.3 13.8 22.3 30.2 38.9 47.2
23248-11 F 7.0 9.4 NA NA NA NA NA
Page 1345 of 4796
23248-12 F 6.8 9.5 NA NA NA NA NA

23248-13 F 6.6 8.8 14.8 23.2 31.6 39.3 48.4
23248-14 F 6.4 8.5 14.4 23.8 31.4 38.4 45.2
23248-15 F 6.7 8.9 NA NA NA NA NA
23248-16 F 6.4 8.6 13.6 21.9 30.2 38.8 46.1
23248-17 F 6.7 8.7 NA NA NA NA NA
MALES MEAN 7.5 10.2 17.2 26.4 33.9 42.4 50.5

FEMALES MEAN 6.6 8.8 14.2 22.8 30.9 38.9 46.7
23217-01 M 6.1 7.7 NA NA NA NA NA

23217-02 M 6.3 8.2 NA NA NA NA NA
23217-03 M 6.0 8.6 13.4 22.8 31.3 37.5 44.3
23217-04 M 6.3 7.6 13.3 21.8 28.3 33.7 41.2
23217-05 M 6.3 8.7 NA NA NA NA NA
23217-06 M 6.0 7.6 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23217-07 M 6.4 8.4 NA NA NA NA NA
23217-08 M 5.7 6.6 10.8 18.3 25.2 30.9 36.3
23217-09 M 6.2 8.1 14.0 23.4 31.2 38.2 44.4
23217-10 F 5.6 7.7 13.1 22.0 29.0 34.8 44.0
23217-11 F 5.0 6.2 9.9 16.5 23.5 29.2 36.9
23217-12 F 5.3 7.1 NA NA NA NA NA
23217-13 F 5.6 7.0 NA NA NA NA NA
23217-14 F 5.8 7.0 NA NA NA NA NA
23217-15 F 5.6 7.5 NA NA NA NA NA
23217-16 F 5.9 8.0 NA NA NA NA NA
Page 1346 of 4796
23217-17 F 5.9 7.7 NA NA NA NA NA

23217-18 F 5.7 7.9 13.6 22.1 31.1 37.5 43.8
23217-19 F 6.0 8.6 NA NA NA NA NA
23217-20 F 5.9 8.0 NA NA NA NA NA
23217-21 F 6.0 7.7 13.1 21.8 30.3 38.3 46.1
MALES MEAN 6.1 7.9 12.9 21.6 29.0 35.1 41.6

FEMALES MEAN 5.7 7.5 12.4 20.6 28.5 35.0 42.7
23190-01 M 5.7 8.4 14.8 25.5 34.7 42.6 56.1

23190-02 M 6.1 8.8 NA NA NA NA NA
23190-03 M 6.3 7.7 13.7 23.5 31.1 39.6 52.1
23190-04 M 6.0 8.2 14.2 22.8 30.0 36.5 47.1
23190-05 M 5.6 7.8 14.0 23.2 31.7 39.8 52.8
23190-06 M 5.6 7.8 NA NA NA NA NA
23190-07 M 6.2 8.8 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23190-08 F 6.0 8.3 14.5 24.3 32.3 39.8 51.9
23190-09 F 6.3 8.7 NA NA NA NA NA
23190-10 F 6.1 8.6 NA NA NA NA NA
23190-11 F 5.7 7.5 NA NA NA NA NA
23190-12 F 5.5 7.2 12.5 21.3 28.5 35.5 46.0
23190-13 F 5.9 8.1 NA NA NA NA NA
23190-14 F 5.8 8.6 NA NA NA NA NA
23190-15 F 5.9 8.6 14.3 23.1 31.9 38.5 52.5
23190-16 F 6.0 8.6 NA NA NA NA NA
23190-17 F 5.9 8.3 14.5 23.4 31.5 37.9 51.0
Page 1347 of 4796
MALES MEAN 5.9 8.2 14.2 23.8 31.9 39.6 52.0

FEMALES MEAN 5.9 8.3 14.0 23.0 31.1 37.9 50.4
23236-01 M 5.9 7.4 11.3 19.2 26.5 34.5 44.1

23236-02 M 6.0 7.3 NA NA NA NA NA
23236-03 M 6.1 7.7 NA NA NA NA NA
23236-04 M 6.3 7.2 NA NA NA NA NA
23236-05 M 6.2 7.3 NA NA NA NA NA
23236-06 M 6.6 8.0 12.7 20.5 26.5 33.6 42.8
23236-07 M 6.1 7.3 12.1 20.7 28.1 34.7 44.3
23236-08 M 5.2 5.4 NA NA NA NA NA
23236-09 M 5.8 6.3 9.8 18.1 25.7 33.1 39.4
23236-11 F 5.3 5.1 NA NA NA NA NA
23236-12 F 5.6 6.5 10.5 17.4 23.0 28.2 35.0
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23236-13 F 5.4 6.2 9.7 17.2 24.7 31.7 36.6
23236-14 F 6.1 7.7 12.3 20.7 28.0 35.2 45.4
23236-15 F 5.8 6.4 10.6 19.3 27.0 33.9 41.5
MALES MEAN 6.0 7.1 11.5 19.6 26.7 34.0 42.7

FEMALES MEAN 5.5 6.4 10.8 18.7 25.7 32.3 39.6
23260-01 M 5.9 7.4 11.8 18.9 26.7 32.2 40.9

23260-02 M 5.5 6.9 NA NA NA NA NA
Page 1348 of 4796
23260-03 M 6.5 8.1 NA NA NA NA NA

23260-04 M 5.8 7.3 11.3 18.5 26.7 33.4 41.7
23260-05 M 6.0 7.8 NA NA NA NA NA
23260-06 M 6.5 7.5 12.1 19.5 26.4 33.6 42.1
23260-07 M 5.8 6.6 10.5 17.1 25.3 30.1 40.4
23260-08 F 5.4 6.6 NA NA NA NA NA
23260-09 F 5.7 7.4 NA NA NA NA NA
23260-10 F 5.4 6.5 10.7 17.3 25.9 32.8 43.2
23260-11 F 5.6 6.8 10.7 17.7 26.1 32.1 39.8
23260-12 F 5.6 7.1 12.2 19.4 24.6 27.0 38.1
23260-13 F 5.7 6.5 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23260-14 F 5.8 7.1 11.9 19.9 26.5 33.8 41.5
MALES MEAN 6.0 7.4 11.4 18.5 26.3 32.3 41.3

FEMALES MEAN 5.6 6.9 11.4 18.6 25.8 31.4 40.7
23221-01 M 7.9 10.3 16.7 24.5 32.1 40.8 52.3

23221-02 M 8.2 11.1 NA NA NA NA NA
23221-03 M 8.7 11.1 NA NA NA NA NA
23221-04 M 7.8 10.5 17.0 25.5 33.5 41.8 53.5
23221-05 M 7.6 10.7 NA NA NA NA NA
Page 1349 of 4796
23221-06 M 7.9 10.3 16.6 26.3 34.1 40.0 54.8

23221-07 M 8.1 11.3 16.7 26.3 33.3 42.2 56.7
23221-08 M 7.9 10.7 NA NA NA NA NA
23221-09 F 7.8 10.3 NA NA NA NA NA
23221-10 F 7.0 9.7 16.0 24.6 32.7 40.7 52.6
23221-11 F 7.2 9.7 15.8 24.0 31.5 39.4 53.4
23221-12 F 8.1 10.6 17.0 25.0 32.2 40.3 54.5
23221-13 F 7.7 10.2 NA NA NA NA NA
23221-14 F 8.0 11.0 17.2 25.5 32.4 37.4 49.5
MALES MEAN 8.0 10.8 16.8 25.7 33.3 41.2 54.3

FEMALES MEAN 7.6 10.3 16.5 24.8 32.2 39.5 52.5
23263-01 M 6.3 8.4 NA NA NA NA NA

23263-02 M 6.7 9.3 15.2 24.3 32.1 39.4 47.3
23263-03 M 5.5 7.4 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23263-04 M 6.3 9.0 NA NA NA NA NA
23263-05 M 6.2 8.3 NA NA NA NA NA
23263-06 M 7.5 10.0 16.1 25.2 31.8 39.0 52.0
23263-07 M 6.6 9.2 NA NA NA NA NA
23263-08 M 7.0 9.6 16.1 25.5 34.2 42.4 52.6
23263-09 M 6.7 9.3 15.8 25.8 34.9 43.2 53.9
23263-10 F 6.2 8.3 13.8 22.9 29.7 36.0 45.1
23263-11 F 6.5 8.4 NA NA NA NA NA
23263-12 F 6.4 8.5 NA NA NA NA NA
23263-13 F 6.2 8.3 13.7 21.7 29.4 36.6 49.0
Page 1350 of 4796
23263-14 F 5.8 7.4 12.2 20.9 27.7 35.5 47.4

23263-15 F 5.8 8.4 13.6 21.7 29.5 37.9 49.4
MALES MEAN 6.5 8.9 15.8 25.2 33.3 41.0 51.5

FEMALES MEAN 6.2 8.2 13.3 21.8 29.1 36.5 47.7
23253-02 M 6.9 8.4 NA NA NA NA NA

23253-03 M 7.8 10.1 16.2 24.3 32.6 40.6 54.6
23253-04 M 7.9 10.0 15.8 24.1 31.4 37.2 51.2
23253-05 M 7.3 10.0 15.7 23.2 31.9 38.4 50.9
23253-06 M 7.2 10.0 NA NA NA NA NA
23253-07 M 8.2 10.4 NA NA NA NA NA
23253-08 M 7.6 10.0 16.5 26.1 35.1 44.0 59.3
23253-09 M 7.8 10.9 NA NA NA NA NA
23253-10 M 7.5 10.0 NA NA NA NA NA
23253-11 M 7.5 10.2 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23253-12 M 6.8 9.6 NA NA NA NA NA
23253-13 F 7.3 9.7 NA NA NA NA NA
23253-14 F 6.8 8.4 13.3 20.5 28.7 40.5 45.1
23253-15 F 6.9 9.1 14.9 23.5 32.1 40.0 49.7
23253-16 F 7.4 10.1 16.3 25.7 33.8 41.3 53.9
23253-17 F 6.9 9.6 15.8 24.4 33.6 41.1 52.8
MALES MEAN 7.5 10.0 16.1 24.4 32.8 40.1 54.0

FEMALES MEAN 7.1 9.4 15.1 23.5 32.1 40.7 50.4
Page 1351 of 4796
23244-01 M 6.3 7.4 10.8 13.6 NA NA NA

23244-02 M 7.2 9.6 NA NA NA NA NA
23244-03 M 6.8 9.3 NA NA NA NA NA
23244-04 M 6.4 9.3 15.1 24.6 33.4 42.3 55.2
23244-05 M 6.6 7.6 NA NA NA NA NA
23244-06 M 6.5 8.8 NA NA NA NA NA
23244-07 M 6.3 8.4 13.2 22.5 31.1 40.7 51.8
23244-08 M 6.4 7.9 NA NA NA NA NA
23244-09 M 5.4 7.1 10.8 19.1 27.7 36.9 47.1
23244-10 M 6.1 8.0 NA NA NA NA NA
23244-11 F 6.3 8.5 NA NA NA NA NA
23244-12 F 6.2 8.0 NA NA NA NA NA
23244-13 F 5.6 8.6 14.5 23.8 33.0 43.1 55.1
23244-14 F 4.6 5.5 NA NA NA NA NA
23244-15 F 5.6 8.0 NA NA NA NA NA
23244-16 F 5.9 7.8 14.1 23.4 31.4 40.6 48.7
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23244-17 F 5.6 7.6 12.9 22.5 32.4 41.5 50.6
MALES MEAN 6.4 8.3 12.5 20.0 30.7 40.0 51.4

FEMALES MEAN 5.7 7.7 13.8 23.2 32.3 41.7 51.5
23218-02 M 7.9 10.6 NA NA NA NA NA

23218-03 M 7.7 10.1 16.3 24.1 33.2 40.0 53.0
23218-04 M 7.5 10.4 NA NA NA NA NA
23218-05 M 7.6 10.5 17.1 26.2 36.2 45.7 57.9
Page 1352 of 4796
23218-07 M 7.5 9.8 NA NA NA NA NA

23218-08 M 7.6 10.1 16.1 24.3 34.1 41.4 53.0
23218-09 M 6.7 8.7 NA NA NA NA NA
23218-10 F 6.6 9.2 NA NA NA NA NA
23218-11 F 7.4 10.1 16.8 25.6 35.1 43.3 56.1
23218-12 F 6.6 9.3 NA NA NA NA NA
23218-13 F 7.3 9.5 NA NA NA NA NA
23218-14 M 7.4 9.7 15.8 24.3 33.1 41.1 53.2
23218-15 F 7.2 9.5 15.0 24.2 34.1 42.7 53.6
23218-16 F 7.4 9.9 15.7 25.1 35.5 42.3 55.4
23218-17 F 7.4 10.0 16.2 25.3 36.0 44.0 57.4
MALES MEAN 7.6 10.0 16.3 24.7 34.2 42.1 54.3

FEMALES MEAN 7.1 9.6 15.9 25.1 35.2 43.1 55.6
23208-01 M 7.7 10.2 17.0 24.9 33.9 38.0 60.0
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23208-02 M 8.3 11.4 NA NA NA NA NA
23208-03 M 8.8 11.8 NA NA NA NA NA
23208-04 M 8.1 11.3 19.3 27.2 37.4 42.0 65.4
23208-05 M 8.7 11.1 17.8 25.4 36.2 44.9 58.2
23208-06 M 8.3 10.7 NA NA NA NA NA
23208-07 M 8.7 11.0 NA NA NA NA NA
23208-08 M 8.6 11.5 18.7 25.5 33.2 41.1 54.8
23208-09 F 8.3 11.6 NA NA NA NA NA
23208-10 F 8.6 10.8 NA NA NA NA NA
23208-11 F 6.5 8.6 15.1 21.6 30.1 45.1 48.7
Page 1353 of 4796
23208-12 F 7.4 9.9 16.7 23.4 31.5 42.8 53.4

23208-13 F 7.7 10.5 18.0 25.6 35.2 41.0 54.2
23208-14 F 7.5 10.1 15.4 23.2 33.1 48.8 55.9
MALES MEAN 8.4 11.1 18.2 25.8 35.2 41.5 59.6

FEMALES MEAN 7.7 10.3 16.3 23.5 32.5 44.4 53.1
23252-01 M 6.5 7.6 12.7 23.5 32.2 40.3 48.3

23252-03 M 6.2 7.8 12.8 24.1 31.5 37.8 47.5
23252-04 M 6.0 7.4 NA NA NA NA NA
23252-05 M 6.1 7.6 NA NA NA NA NA
23252-06 M 6.4 8.0 10.6 NA NA NA NA
23252-07 M 6.0 7.5 13.0 25.8 34.4 43.2 45.6
23252-08 M 6.1 7.1 NA NA NA NA NA
23252-09 M 6.4 7.7 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23252-10 M 6.3 7.4 NA NA NA NA NA
23252-11 F 5.6 6.5 NA NA NA NA NA
23252-12 F 6.4 7.8 12.8 24.4 32.0 37.8 48.3
23252-13 F 6.1 7.6 12.6 24.1 32.4 40.6 47.8
23252-14 F 6.1 7.3 NA NA NA NA NA
23252-15 F 6.3 7.6 13.8 25.3 33.8 41.4 51.6
23252-16 F 5.4 6.7 11.2 19.3 26.5 33.9 41.6
23252-17 F 6.1 7.3 NA NA NA NA NA
MALES MEAN 6.1 7.6 12.3 24.5 32.7 40.4 47.1

Page 1354 of 4796
FEMALES MEAN 6.0 7.3 12.6 23.3 31.2 38.4 47.3
26510-01 M 6.6 8.9 NA NA NA NA NA

26510-02 M 7.3 9.5 17.0 25.2 31.3 38.2 49.1
26510-03 M 7.2 10.0 17.0 25.5 31.5 39.1 50.1
26510-04 M 7.3 10.2 NA NA NA NA NA
26510-05 M 7.6 9.9 NA NA NA NA NA
26510-06 M 7.4 10.2 NA NA NA NA NA
26510-07 M 6.8 9.2 NA NA NA NA NA
26510-08 M 7.0 9.7 NA NA NA NA NA
26510-09 M 6.6 8.7 15.2 22.5 28.5 36.3 43.6
26510-10 M 7.5 10.5 NA NA NA NA NA
26510-11 F 6.3 8.9 NA NA NA NA NA
26510-12 F 7.0 8.9 15.4 24.0 28.4 36.3 46.8
26510-13 F 5.4 6.2 9.7 14.5 NA NA NA
26510-14 F 6.3 8.8 15.0 22.7 28.0 36.2 NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26510-15 F 6.7 9.2 15.8 22.5 28.1 35.2 NA
MALES MEAN 7.1 9.7 16.4 24.4 30.4 37.9 47.6

FEMALES MEAN 6.3 8.4 14.0 20.9 28.2 35.9 46.8
26519-01 F 6.4 9.0 NA NA NA NA NA

26519-03 M 7.1 10.1 17.1 26.6 36.3 44.5 58.5
26519-04 M 7.3 10.6 18.1 29.4 38.2 47.0 63.1
26519-05 M 6.9 9.7 NA NA NA NA NA
Page 1355 of 4796
26519-06 M 7.2 10.2 17.8 29.6 38.9 47.5 61.1

26519-07 M 7.1 10.5 18.0 29.7 38.4 47.1 63.0
26519-08 F 7.0 10.5 17.7 27.9 36.6 45.2 59.2
26519-09 F 6.4 9.9 16.9 27.8 36.7 44.9 55.5
26519-10 F 7.0 10.1 NA NA NA NA NA
26519-11 F 6.3 8.3 15.0 25.9 35.7 43.9 54.9
26519-12 F 6.7 10.0 NA NA NA NA NA
26519-13 F 6.5 9.3 NA NA NA NA NA
26519-14 F 5.9 8.3 NA NA NA NA NA
26519-15 F 5.9 8.8 15.3 25.2 33.7 40.6 52.9
MALES MEAN 7.2 10.2 17.8 28.8 38.0 46.5 61.4

FEMALES MEAN 6.5 9.4 16.2 26.7 35.7 43.7 55.6
26468-02 M 5.6 7.1 10.8 13.7 17.7 22.1 26.6

26468-03 M 7.7 10.3 17.3 25.5 32.5 39.8 59.0
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26468-04 M 7.8 11.4 18.4 27.8 34.9 41.4 57.8
26468-05 M 7.8 11.7 18.6 28.0 35.9 44.7 60.2
26468-06 M 6.9 10.3 NA NA NA NA NA
26468-07 M 7.0 10.5 NA NA NA NA NA
26468-08 M 7.8 11.1 NA NA NA NA NA
26468-09 F 7.1 10.3 17.3 25.8 33.0 38.5 54.6
26468-10 F 7.4 10.2 16.9 25.5 33.7 41.2 56.2
26468-11 F 7.0 10.3 NA NA NA NA NA
26468-12 F 7.4 11.0 17.6 25.9 32.5 40.0 50.6
26468-13 F 7.5 10.7 17.5 26.1 33.1 40.1 53.8
Page 1356 of 4796
MALES MEAN 7.2 10.3 16.3 23.8 30.3 37.0 50.9

FEMALES MEAN 7.3 10.5 17.3 25.8 33.1 40.0 53.8
26475-01 M 6.9 9.8 16.1 26.6 34.6 43.7 56.9

26475-02 M 7.1 10.2 16.0 24.9 32.3 39.2 51.2
26475-03 M 7.8 10.6 17.4 27.4 33.8 39.6 53.4
26475-04 F 7.6 10.6 NA NA NA NA NA
26475-05 M 7.8 10.8 16.9 25.9 33.8 40.9 54.3
26475-06 F 7.2 10.2 16.1 25.1 32.2 37.9 50.7
26475-07 F 6.9 9.9 NA NA NA NA NA
26475-08 F 6.7 9.3 NA NA NA NA NA
26475-09 F 7.0 9.7 15.6 24.4 31.2 37.0 48.4
26475-10 F 8.0 11.0 NA NA NA NA NA
26475-11 F 7.2 9.6 NA NA NA NA NA
26475-12 F 7.1 10.1 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26475-13 F 7.0 9.5 15.6 25.5 31.8 38.2 50.3
26475-14 F 7.0 10.4 16.3 25.4 33.6 39.6 51.8
MALES MEAN 7.4 10.4 16.6 26.2 33.6 40.9 54.0

FEMALES MEAN 7.2 10.0 15.9 25.1 32.2 38.2 50.3
26532-01 M 6.7 8.7 NA NA NA NA NA

26532-02 M 6.4 9.0 NA NA NA NA NA
26532-03 M 6.1 8.7 15.3 25.1 33.3 41.7 54.3
26532-04 M 6.5 8.9 14.6 23.8 32.2 39.7 52.5
Page 1357 of 4796
26532-05 M 6.3 8.8 NA NA NA NA NA

26532-06 M 6.7 8.5 14.8 24.6 32.9 40.6 53.0
26532-07 M 6.2 8.5 NA NA NA NA NA
26532-08 M 6.7 9.1 15.6 25.8 34.7 42.9 51.0
26532-09 F 6.1 8.1 NA NA NA NA NA
26532-10 F 6.0 8.2 14.9 24.4 32.7 40.6 52.0
26532-11 F 5.8 8.5 NA NA NA NA NA
26532-12 F 6.3 8.4 NA NA NA NA NA
26532-13 F 6.1 9.0 16.0 26.1 35.1 42.2 53.8
26532-14 F 5.9 7.5 13.6 22.9 31.2 38.1 47.5
26532-15 F 5.9 7.8 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26532-16 F 5.9 8.5 14.4 23.7 31.3 37.3 49.9
MALES MEAN 6.5 8.8 15.1 24.8 33.3 41.2 52.7

FEMALES MEAN 6.0 8.3 14.7 24.3 32.6 39.6 50.8
26507-01 F 5.9 8.3 NA NA NA NA NA

26507-02 M 6.4 9.2 16.2 26.0 33.8 40.6 54.4
26507-03 M 5.8 8.3 14.7 24.8 34.2 41.8 54.4
26507-04 M 6.2 9.0 15.5 24.8 32.3 38.5 50.4
26507-05 M 6.3 9.0 NA NA NA NA NA
Page 1358 of 4796
26507-06 M 6.0 8.3 NA NA NA NA NA

26507-07 M 5.9 8.5 NA NA NA NA NA
26507-08 M 7.0 10.0 17.7 28.2 36.4 44.7 55.1
26507-09 M 6.4 8.0 NA NA NA NA NA
26507-10 F 6.2 8.8 NA NA NA NA NA
26507-11 F 5.9 8.5 NA NA NA NA NA
26507-12 F 6.3 9.0 NA NA NA NA NA
26507-13 F 5.3 7.8 14.0 23.7 31.4 37.9 49.6
26507-14 F 6.0 8.4 15.2 25.6 33.1 39.0 50.5
26507-15 F 6.1 8.7 NA NA NA NA NA
26507-16 F 6.4 9.3 16.7 26.5 35.1 43.4 55.6
26507-17 F 5.9 8.2 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26507-18 F 5.6 7.8 14.6 24.3 33.4 38.9 50.0
MALES MEAN 6.3 8.8 16.0 26.0 34.2 41.4 53.6

FEMALES MEAN 6.0 8.5 15.1 25.0 33.3 39.8 51.4
26480-01 M 6.7 9.4 NA NA NA NA NA

26480-02 M 6.8 11.1 16.9 27.0 36.0 45.7 57.8
26480-03 M 6.9 10.7 17.2 27.5 36.9 47.2 59.1
26480-04 M 6.3 9.7 16.0 26.3 35.8 45.8 59.1
26480-05 M 6.7 10.3 15.2 25.3 33.9 40.7 52.8
Page 1359 of 4796
26480-06 M 6.3 9.0 NA NA NA NA NA

26480-07 M 6.4 9.5 NA NA NA NA NA
26480-09 M 7.2 11.1 NA NA NA NA NA
26480-10 F 6.4 8.5 NA NA NA NA NA
26480-11 F 6.5 10.1 16.0 26.2 35.4 42.5 56.8
26480-12 F 6.7 10.6 NA NA NA NA NA
26480-13 F 6.3 9.0 13.8 22.0 30.7 40.4 49.9
26480-14 F 6.7 9.7 NA NA NA NA NA
26480-15 F 6.0 8.3 13.0 22.0 31.2 39.3 49.0
26480-16 F 3.6 4.1 5.7 9.8 15.7 21.8 27.6
26480-18 F 5.7 9.4 NA NA NA NA NA
MALES MEAN 6.7 10.1 16.3 26.5 35.7 44.9 57.2

FEMALES MEAN 6.0 8.7 12.1 20.0 28.3 36.0 45.8
26482-01 M 7.1 10.6 17.1 25.6 32.3 40.6 54.6
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26482-02 M 7.1 11.1 NA NA NA NA NA
26482-03 M 7.6 11.2 18.4 27.8 35.5 43.2 59.8
26482-04 M 7.0 10.9 NA NA NA NA NA
26482-05 M 7.4 11.0 17.8 27.0 32.6 39.6 58.2
26482-06 M 7.7 11.3 17.6 26.4 33.2 41.0 57.7
26482-07 F 7.4 10.8 17.5 26.4 33.4 40.1 55.7
26482-08 F 7.3 10.2 NA NA NA NA NA
26482-09 F 6.7 9.9 NA NA NA NA NA
26482-10 F 6.4 9.6 NA NA NA NA NA
26482-11 F 7.4 10.8 17.4 26.7 33.4 41.6 57.0
Page 1360 of 4796
26482-12 F 6.4 9.3 14.9 24.2 31.7 39.2 52.7

26482-13 F 6.7 9.6 15.6 24.8 31.0 37.6 53.1
MALES MEAN 7.3 11.0 17.7 26.7 33.4 41.1 57.6

FEMALES MEAN 6.9 10.0 16.4 25.5 32.4 39.6 54.6
26522-01 M 8.1 11.1 18.7 28.9 37.0 44.5 58.5

26522-02 M 7.4 10.4 17.2 27.2 34.8 41.6 53.9
26522-03 M 8.2 11.3 18.8 29.4 37.0 44.5 59.7
26522-04 M 7.5 10.9 18.2 28.8 35.6 41.0 54.3
26522-05 F 7.5 10.7 17.8 27.0 35.2 41.7 54.8
26522-06 F 6.9 10.0 17.0 26.4 33.7 40.0 51.2
26522-07 F 7.5 10.6 NA NA NA NA NA
26522-08 F 7.9 10.6 NA NA NA NA NA
26522-09 F 7.3 9.7 NA NA NA NA NA
26522-10 F 7.6 10.6 16.9 27.2 34.6 42.6 55.1
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26522-11 F 7.1 9.8 NA NA NA NA NA
26522-12 F 7.5 10.8 17.8 27.7 34.7 40.8 52.3
26522-13 F 7.7 10.5 NA NA NA NA NA
26522-14 F 7.8 8.8 NA NA NA NA NA
MALES MEAN 7.8 10.9 18.2 28.6 36.1 42.9 56.6

FEMALES MEAN 7.5 10.2 17.4 27.1 34.6 41.3 53.4
26517-01 M 8.1 11.0 NA NA NA NA NA

26517-02 M 6.8 9.2 16.6 25.3 32.6 40.3 53.9
Page 1361 of 4796
26517-03 M 8.1 12.0 19.2 30.2 37.3 45.9 60.6

26517-04 M 7.8 11.5 19.5 30.0 36.3 43.0 59.1
26517-05 M 7.3 10.3 17.6 27.1 35.2 42.6 57.3
26517-06 M 7.2 9.9 NA NA NA NA NA
26517-07 M 7.9 10.9 NA NA NA NA NA
26517-08 F 7.6 10.6 17.8 26.2 33.5 40.7 51.6
26517-09 F 7.2 10.2 NA NA NA NA NA
26517-10 F 6.8 9.5 NA NA NA NA NA
26517-11 F 6.6 9.6 NA NA NA NA NA
26517-12 F 7.0 10.2 17.3 27.6 36.1 43.9 54.2
26517-13 F 7.5 10.5 NA NA NA NA NA
26517-14 F 6.9 10.2 17.3 28.5 36.0 42.1 57.8
26517-15 F 7.4 10.6 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26517-16 F 7.0 10.0 17.2 28.5 36.2 44.6 55.0
MALES MEAN 7.6 10.7 18.2 28.2 35.4 43.0 57.7

FEMALES MEAN 7.1 10.2 17.4 27.7 35.5 42.8 54.7
26514-01 M 6.8 9.7 16.3 26.5 33.9 41.8 53.7

26514-02 M 6.6 8.4 NA NA NA NA NA
26514-03 M 6.9 9.2 NA NA NA NA NA
26514-04 M 6.4 9.1 NA NA NA NA NA
26514-05 M 7.1 10.1 NA NA NA NA NA
Page 1362 of 4796
26514-06 M 7.1 9.6 16.1 27.2 34.9 41.5 54.8

26514-07 M 7.2 10.0 15.6 26.2 33.7 40.3 56.5
26514-08 M 6.5 9.0 14.7 25.8 33.7 42.3 55.2
26514-09 M 7.0 10.1 NA NA NA NA NA
26514-10 F 6.9 9.8 NA NA NA NA NA
26514-11 F 6.5 8.7 NA NA NA NA NA
26514-12 F 6.7 9.0 NA NA NA NA NA
26514-13 F 6.3 8.3 12.9 21.8 29.9 36.7 48.1
26514-14 F 6.5 8.7 14.0 23.7 31.2 36.1 50.1
26514-15 F 6.9 9.4 15.7 25.2 33.5 39.8 54.3
26514-16 F 6.5 9.4 14.7 26.2 33.9 41.8 55.5
MALES MEAN 6.8 9.5 15.7 26.4 34.1 41.5 55.1

FEMALES MEAN 6.6 9.0 14.3 24.2 32.1 38.6 52.0
26534-01 M 7.8 11.2 18.8 29.0 34.8 40.6 50.9
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26534-02 M 6.9 9.7 NA NA NA NA NA
26534-03 M 7.1 10.1 NA NA NA NA NA
26534-04 M 7.7 11.8 19.3 30.5 37.9 45.7 59.6
26534-05 M 7.9 11.6 18.8 29.8 37.8 46.4 57.5
26534-06 M 7.0 10.3 17.3 28.0 36.1 43.9 53.9
26534-07 F 7.3 9.3 NA NA NA NA NA
26534-08 F 7.2 10.3 16.6 27.9 35.4 42.8 53.1
26534-09 F 6.8 10.5 NA NA NA NA NA
26534-10 F 7.3 9.9 16.2 27.1 35.7 42.8 53.3
26534-11 F 6.7 9.5 NA NA NA NA NA
Page 1363 of 4796
26534-12 F 7.3 9.9 NA NA NA NA NA

26534-13 F 7.1 9.1 15.3 26.3 33.5 41.8 51.0
26534-14 F 7.4 10.4 NA NA NA NA NA
26534-15 F 6.7 9.2 NA NA NA NA NA
26534-16 F 7.5 10.3 18.1 29.2 36.4 42.7 52.1
MALES MEAN 7.4 10.8 18.6 29.3 36.7 44.2 55.5

FEMALES MEAN 7.1 9.8 16.6 27.6 35.3 42.5 52.4
MALES MEAN 7.0 9.5 15.8 25.0 33.0 40.5 52.5

S.D. 0.71 1.25 2.19 2.80 2.90 3.30 5.32
S.E. 0.15 0.25 0.45 0.57 0.59 0.67 1.09
N 24 24 24 24 24 24 24
FEMALES MEAN 6.6 8.9 14.7 23.7 31.7 39.1 50.0

S.D. 0.69 1.18 1.93 2.59 2.83 3.35 4.48
S.E. 0.14 0.24 0.39 0.53 0.58 0.68 0.91
N 24 24 24 24 24 24 24
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23179-01 M 8.4 11.2 17.1 27.2 34.5 41.2 51.0
23179-02 M 7.7 9.6 15.1 26.2 35.9 43.1 54.6
23179-03 M 8.4 11.7 17.9 29.7 37.9 46.0 58.7
23179-04 M 7.8 11.4 18.0 27.7 33.1 39.9 50.6
23179-05 F 7.1 9.6 NA NA NA NA NA
23179-06 F 6.7 9.0 13.6 21.5 26.7 32.4 42.3
23179-07 F 7.3 10.1 NA NA NA NA NA
23179-08 F 7.3 10.7 16.9 26.9 34.0 40.7 55.6
23179-09 F 7.9 10.2 15.5 25.7 32.7 38.5 50.3
23179-10 F 7.5 10.4 15.8 25.8 32.3 38.5 52.2
Page 1364 of 4796
MALES MEAN 8.1 11.0 17.0 27.7 35.4 42.6 53.7

FEMALES MEAN 7.3 10.0 15.5 25.0 31.4 37.5 50.1
23212-02 M 6.8 8.4 13.6 22.7 32.6 40.8 54.1

23212-03 M 7.8 10.0 NA NA NA NA NA
23212-04 M 7.6 9.8 NA NA NA NA NA
23212-05 M 7.3 9.3 NA NA NA NA NA
23212-06 M 7.6 9.3 NA NA NA NA NA
23212-07 M 7.3 9.0 14.8 25.6 33.4 40.4 53.1
23212-08 M 8.0 9.6 15.2 26.8 35.4 44.6 57.7
23212-09 M 6.8 8.6 13.6 23.3 32.1 40.2 52.9
23212-10 F 7.3 9.2 NA NA NA NA NA
23212-11 F 7.7 10.2 16.3 27.5 35.1 42.2 54.9
23212-12 F 7.3 9.7 NA NA NA NA NA
23212-13 F 6.9 8.2 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23212-14 F 7.5 9.1 NA NA NA NA NA
23212-15 F 7.0 8.9 14.9 25.5 34.9 44.7 57.4
23212-16 F 7.0 9.4 15.4 26.6 35.6 43.2 53.2
23212-17 F 7.0 8.9 14.4 24.3 33.9 42.2 53.3
23212-18 F 7.4 9.5 NA NA NA NA NA
MALES MEAN 7.4 9.3 14.3 24.6 33.4 41.5 54.5

FEMALES MEAN 7.2 9.2 15.3 26.0 34.9 43.1 54.7
23201-02 M 6.9 8.1 12.1 19.3 25.1 32.0 38.0

Page 1365 of 4796
23201-03 M 6.7 8.2 12.8 20.4 29.6 37.8 49.0

23201-04 M 6.7 8.1 12.5 19.2 29.5 35.9 44.7
23201-05 F 6.2 8.0 NA NA NA NA NA
23201-06 F 6.4 8.1 12.2 19.7 28.5 37.2 46.7
23201-07 F 6.3 7.3 NA NA NA NA NA
23201-08 F 6.3 8.0 11.0 16.4 21.1 26.0 30.6
23201-09 F 6.2 7.7 11.9 19.1 28.0 37.4 46.9
23201-10 F 6.3 7.8 NA NA NA NA NA
23201-11 F 6.0 7.0 10.9 16.5 23.9 30.3 36.0
23201-13 F 6.2 7.6 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23201-14 F 6.5 8.2 11.9 17.7 25.8 31.9 40.0
MALES MEAN 6.8 8.1 12.5 19.6 28.1 35.2 43.9

FEMALES MEAN 6.3 7.7 11.6 17.9 25.5 32.6 40.0
23259-02 M 7.6 10.2 16.4 25.8 33.5 41.7 55.7

23259-03 M 7.7 11.4 18.5 28.6 38.5 46.9 60.1
23259-04 M 6.4 9.2 NA NA NA NA NA
23259-05 M 7.1 10.7 17.5 27.1 37.8 47.1 58.7
23259-06 M 7.0 10.2 16.8 26.0 36.0 44.7 57.5
Page 1366 of 4796
23259-07 F 6.7 9.3 NA NA NA NA NA

23259-08 F 7.2 10.4 NA NA NA NA NA
23259-09 F 6.7 9.4 15.3 23.6 33.1 41.6 53.5
23259-10 F 7.3 10.4 17.4 26.7 36.8 47.1 57.9
23259-11 F 7.1 10.4 16.8 26.5 34.8 42.2 53.0
23259-12 F 7.0 9.5 NA NA NA NA NA
23259-13 F 6.5 10.4 17.0 26.2 34.9 43.9 54.9
MALES MEAN 7.2 10.3 17.3 26.9 36.5 45.1 58.0

FEMALES MEAN 6.9 10.0 16.6 25.8 34.9 43.7 54.8
23210-01 M 7.5 10.3 16.7 25.3 33.2 40.4 52.2

23210-02 M 7.3 10.5 NA NA NA NA NA
23210-03 M 7.1 10.2 17.1 25.7 33.4 40.3 51.2
23210-04 M 7.2 10.1 NA NA NA NA NA
23210-05 M 6.7 9.4 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23210-06 M 7.5 10.4 17.6 25.9 33.0 39.5 50.4
23210-07 M 7.7 9.9 NA NA NA NA NA
23210-08 M 7.8 11.3 NA NA NA NA NA
23210-09 M 7.1 9.6 16.2 25.3 32.8 37.4 47.9
23210-10 M 6.9 9.8 NA NA NA NA NA
23210-11 F 7.1 9.8 NA NA NA NA NA
23210-12 F 6.4 9.0 14.8 22.0 29.2 35.7 43.8
23210-13 F 6.9 9.2 NA NA NA NA NA
23210-14 F 6.7 9.7 15.8 24.8 31.9 38.7 49.9
23210-15 F 6.6 8.7 14.4 22.9 30.2 36.9 46.3
Page 1367 of 4796
23210-16 F 6.6 9.1 15.9 23.9 31.5 37.4 45.2
MALES MEAN 7.3 10.2 16.9 25.6 33.1 39.4 50.4

FEMALES MEAN 6.7 9.3 15.2 23.4 30.7 37.2 46.3
23256-01 M 6.7 9.0 NA NA NA NA NA

23256-02 M 6.3 8.7 NA NA NA NA NA
23256-03 M 7.1 8.7 NA NA NA NA NA
23256-04 M 7.4 9.9 16.6 24.0 31.9 38.2 47.5
23256-05 M 6.6 8.8 NA NA NA NA NA
23256-06 M 6.3 8.2 NA NA NA NA NA
23256-07 M 7.0 9.4 16.0 24.3 30.4 36.6 46.1
23256-08 M 6.6 9.1 16.0 23.6 32.0 38.9 49.4
23256-09 M 7.0 9.4 16.1 24.7 30.2 35.7 45.8
23256-10 F 6.7 8.9 NA NA NA NA NA
23256-11 F 6.1 8.1 14.2 21.5 28.0 32.8 42.0
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23256-12 F 6.5 8.9 NA NA NA NA NA
23256-13 F 7.0 9.6 11.2 24.6 30.3 36.2 45.2
23256-14 F 6.7 8.3 16.4 20.6 28.1 35.4 44.9
23256-15 F 6.8 8.9 NA NA NA NA NA
23256-16 F 5.4 7.3 14.2 18.3 25.9 31.4 39.3
MALES MEAN 6.8 9.0 16.2 24.2 31.1 37.4 47.2

FEMALES MEAN 6.5 8.6 14.0 21.3 28.1 34.0 42.9
23238-01 M 7.0 9.1 NA NA NA NA NA

Page 1368 of 4796
23238-02 M 7.1 9.9 16.5 25.6 32.3 39.9 53.2

23238-03 M 6.2 7.7 12.7 19.4 25.9 33.2 44.5
23238-04 M 6.8 8.4 14.5 24.2 32.8 40.5 53.9
23238-05 M 7.3 9.2 NA NA NA NA NA
23238-06 M 6.7 8.8 NA NA NA NA NA
23238-07 M 6.9 8.6 14.9 24.1 31.3 39.2 51.5
23238-08 F 7.1 8.7 14.5 23.8 32.0 37.6 50.2
23238-09 F 6.1 7.9 13.1 21.6 29.5 37.4 49.2
23238-10 F 7.4 10.1 NA NA NA NA NA
23238-11 F 6.5 8.4 NA NA NA NA NA
23238-12 F 7.1 9.1 NA NA NA NA NA
23238-13 F 6.7 8.6 14.1 23.3 31.2 39.0 51.9
23238-14 F 6.3 8.5 NA NA NA NA NA
23238-15 F 6.8 9.7 NA NA NA NA NA
23238-16 F 6.9 8.8 15.2 24.2 31.6 39.9 52.1
23238-17 F 6.4 7.8 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23238-18 F 5.9 7.5 NA NA NA NA NA
MALES MEAN 6.9 8.8 14.7 23.3 30.6 38.2 50.8

FEMALES MEAN 6.7 8.6 14.2 23.2 31.1 38.5 50.9
23228-01 M 8.0 10.9 NA NA NA NA NA

23228-02 M 6.7 9.2 NA NA NA NA NA
23228-03 M 7.5 9.9 15.8 23.6 30.4 37.3 50.4
23228-04 M 8.1 10.7 17.5 25.7 32.8 38.3 51.4
23228-05 M 7.7 9.5 15.8 24.6 31.0 36.7 49.4
Page 1369 of 4796
23228-06 M 7.3 9.9 NA NA NA NA NA

23228-07 M 7.8 9.4 15.1 23.9 29.9 35.3 45.9
23228-08 F 7.9 10.1 16.3 25.2 31.6 36.9 49.5
23228-09 F 7.4 10.1 NA NA NA NA NA
23228-10 F 6.6 8.2 13.9 21.7 27.8 34.1 44.3
23228-11 F 7.0 9.1 14.9 23.4 29.4 35.0 47.4
23228-12 F 7.2 8.7 14.3 21.9 27.5 33.4 44.4
23228-13 F 7.1 8.9 NA NA NA NA NA
23228-14 F 6.4 8.3 NA NA NA NA NA
23228-15 F 6.9 9.1 NA NA NA NA NA
23228-16 F 7.8 9.9 NA NA NA NA NA
MALES MEAN 7.6 9.9 16.1 24.5 31.0 36.9 49.3

FEMALES MEAN 7.1 9.2 14.9 23.1 29.1 34.9 46.4
23246-01 M 8.7 11.9 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23246-02 M 8.8 13.2 NA NA NA NA NA
23246-03 M 8.6 12.1 NA NA NA NA NA
23246-04 M 8.9 12.6 NA NA NA NA NA
23246-05 M 8.0 11.9 NA NA NA NA NA
23246-06 F 8.5 12.0 NA NA NA NA NA
23246-07 F 8.5 11.9 NA NA NA NA NA
MALES MEAN 8.6 12.3

FEMALES MEAN 8.5 12.0
Page 1370 of 4796
23220-01 M 7.3 9.8 NA NA NA NA NA

23220-02 M 7.2 10.3 NA NA NA NA NA
23220-03 M 7.8 11.1 NA NA NA NA NA
23220-04 M 7.1 10.4 NA NA NA NA NA
23220-05 M 7.0 10.0 NA NA NA NA NA
23220-06 M 6.9 9.9 NA NA NA NA NA
23220-07 M 7.2 10.2 17.2 28.1 35.9 45.9 59.6
23220-08 M 6.9 9.6 16.4 25.9 33.2 43.3 58.4
23220-09 M 7.1 9.5 15.9 23.4 29.9 37.9 49.0
23220-10 M 5.8 8.7 NA NA NA NA NA
23220-11 M 7.2 10.0 17.2 20.4 28.1 38.1 45.8
23220-12 M 7.7 10.4 NA NA NA NA NA
23220-13 F 6.1 7.9 13.3 22.9 30.4 39.0 50.7
23220-14 F 6.3 8.9 14.5 23.7 31.1 41.0 51.8
23220-15 F 6.8 9.5 16.2 24.8 31.3 38.7 51.9
23220-16 F 6.4 8.6 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23220-17 F 7.1 9.9 NA NA NA NA NA
23220-18 F 6.7 9.2 14.3 24.6 32.0 40.9 51.3
MALES MEAN 7.1 10.0 16.7 24.5 31.8 41.3 53.2

FEMALES MEAN 6.6 9.0 14.6 24.0 31.2 39.9 51.4
23183-01 M 8.1 11.0 17.8 30.1 37.0 46.3 55.7

23183-02 M 8.2 10.8 NA NA NA NA NA
23183-03 M 8.4 11.1 NA NA NA NA NA
23183-04 M 8.3 11.3 17.7 29.4 35.7 42.8 55.1
Page 1371 of 4796
23183-06 M 8.8 12.2 18.1 29.5 36.8 46.4 57.2
23183-07 M 9.4 11.3 18.7 29.9 37.4 46.1 54.8
23183-08 F 7.4 9.9 15.2 25.8 31.1 37.6 48.0
23183-09 F 8.9 11.4 NA NA NA NA NA
23183-10 F 8.6 11.0 17.2 29.0 36.3 45.6 51.9
23183-11 F 8.4 11.3 17.5 30.1 37.1 46.1 54.4
23183-12 F 8.4 10.8 18.5 29.6 36.9 46.2 53.9
MALES MEAN 8.5 11.3 18.1 29.7 36.7 45.4 55.7

FEMALES MEAN 8.3 10.9 17.1 28.6 35.4 43.9 52.1
23184-01 M 7.4 9.2 16.0 26.9 33.9 41.7 52.1

23184-02 M 7.7 10.0 NA NA NA NA NA
23184-03 M 7.5 10.3 18.1 29.4 37.8 45.8 57.2
23184-04 M 7.4 9.5 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23184-05 M 8.2 10.0 NA NA NA NA NA
23184-06 M 7.2 9.1 15.9 25.5 33.1 39.4 51.8
23184-07 M 7.9 9.9 17.0 28.5 36.5 44.3 55.2
23184-08 F 7.0 8.8 15.0 24.9 31.7 36.8 48.2
23184-09 F 7.6 9.9 NA NA NA NA NA
23184-10 F 6.7 9.0 NA NA NA NA NA
23184-11 F 7.3 10.4 NA NA NA NA NA
23184-12 F 7.4 9.1 NA NA NA NA NA
23184-13 F 7.5 9.4 NA NA NA NA NA
23184-14 F 7.4 9.8 16.7 27.4 34.6 42.3 49.1
Page 1372 of 4796
23184-15 F 7.1 9.0 15.7 25.8 33.4 41.0 51.7

23184-16 F 7.9 9.8 16.7 27.3 35.2 41.7 51.8
MALES MEAN 7.6 9.7 16.8 27.6 35.3 42.8 54.1

FEMALES MEAN 7.3 9.5 16.0 26.4 33.7 40.5 50.2
26516-05 M 5.7 8.7 NA NA NA NA NA

26516-11 M 5.5 8.9 NA NA NA NA NA
26516-12 M 5.7 9.6 NA NA NA NA NA
26516-13 F 5.6 9.7 NA NA NA NA NA
26516-14 F 5.8 10.2 NA NA NA NA NA
MALES MEAN 5.6 9.1

26497-01 M 8.1 10.9 18.3 29.1 38.9 45.5 64.5
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26497-02 M 8.2 11.6 NA NA NA NA NA
26497-04 M 8.3 10.4 NA NA NA NA NA
26497-05 M 7.2 9.8 NA NA NA NA NA
26497-06 M 7.3 9.5 16.1 25.4 35.3 43.3 59.1
26497-07 M 7.2 9.3 NA NA NA NA NA
26497-08 M 8.5 11.2 NA NA NA NA NA
26497-09 M 7.4 10.0 16.7 27.1 36.5 44.5 60.4
26497-10 M 6.9 9.2 16.1 26.0 34.8 41.6 60.0
26497-11 F 6.7 9.5 17.0 27.6 36.5 43.9 57.1
Page 1373 of 4796
26497-12 F 7.3 10.0 NA NA NA NA NA

26497-13 F 7.5 10.2 17.0 26.9 35.3 43.4 60.1
26497-14 F 7.7 10.9 NA NA NA NA NA
26497-15 F 6.6 8.9 15.3 24.5 32.7 40.5 52.8
26497-16 F 7.0 9.8 16.3 24.3 32.4 36.3 52.5
MALES MEAN 7.7 10.2 16.8 26.9 36.4 43.7 61.0

FEMALES MEAN 7.1 9.9 16.4 25.8 34.2 41.0 55.6
26495-01 M 7.2 9.8 16.3 25.4 33.4 41.3 55.2

26495-02 M 8.1 10.3 NA NA NA NA NA
26495-03 M 7.7 10.5 17.6 26.4 33.2 39.4 48.2
26495-04 M 7.2 9.3 NA NA NA NA NA
26495-05 M 7.9 10.0 16.7 25.9 34.5 41.6 54.4
26495-06 M 7.5 9.4 16.6 25.8 34.6 41.3 48.5
26495-07 M 8.7 11.0 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26495-08 F 5.9 6.6 NA NA NA NA NA
26495-09 F 7.0 8.9 15.3 24.8 31.8 39.1 47.9
26495-10 F 7.5 9.8 16.5 26.0 34.1 41.9 53.6
26495-11 F 7.4 10.3 NA NA NA NA NA
26495-12 F 7.3 9.7 16.0 25.5 33.6 40.0 49.4
26495-13 F 7.0 9.2 NA NA NA NA NA
26495-14 F 7.3 9.9 16.6 26.0 33.6 40.8 50.9
MALES MEAN 7.8 10.0 16.8 25.9 33.9 40.9 51.6

FEMALES MEAN 7.1 9.2 16.1 25.6 33.3 40.5 50.5
Page 1374 of 4796
26499-01 M 7.4 10.4 NA NA NA NA NA

26499-03 M 7.5 11.2 NA NA NA NA NA
26499-04 M 7.6 10.6 17.7 26.9 34.7 42.8 58.5
26499-05 M 7.5 11.1 NA NA NA NA NA
26499-06 M 6.5 10.0 16.8 26.1 33.4 42.8 56.1
26499-07 M 6.9 9.7 17.0 27.2 35.6 44.5 57.8
26499-08 M 6.8 9.9 16.5 25.4 34.6 42.6 53.7
26499-09 F 5.8 8.5 NA NA NA NA NA
26499-10 F 6.4 9.1 15.9 26.2 34.9 43.2 55.3
26499-11 F 6.3 8.9 15.6 24.1 32.6 41.3 54.1
26499-12 F 6.0 8.5 14.2 22.5 30.6 37.2 48.7
26499-13 F 6.4 9.6 NA NA NA NA NA
26499-14 F 6.3 9.0 15.4 24.7 32.9 41.2 54.9
26499-15 F 6.2 9.2 NA NA NA NA NA
26499-16 F 6.7 9.5 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26499-17 F 7.1 7.1 NA NA NA NA NA
MALES MEAN 7.2 10.4 17.0 26.4 34.6 43.2 56.5

FEMALES MEAN 6.4 8.8 15.3 24.4 32.8 40.7 53.3
26494-01 M 6.9 9.7 15.9 25.1 31.5 38.1 50.8

26494-02 M 6.7 9.7 NA NA NA NA NA
26494-03 M 6.3 9.1 15.1 25.5 33.8 40.9 53.7
26494-04 M 6.7 9.1 14.6 24.0 32.0 40.0 51.3
26494-05 M 6.5 9.2 NA NA NA NA NA
Page 1375 of 4796
26494-06 M 6.2 9.0 15.1 25.5 34.8 42.1 53.4

26494-07 F 6.1 9.1 NA NA NA NA NA
26494-08 F 5.9 8.9 14.4 24.1 31.7 38.6 49.9
26494-09 F 5.2 7.3 11.8 20.7 27.5 33.5 40.1
26494-10 F 5.2 7.6 12.1 20.1 28.5 35.3 43.3
26494-11 F 6.2 9.3 NA NA NA NA NA
26494-12 F 5.9 8.6 13.6 23.6 32.0 38.9 49.3
MALES MEAN 6.6 9.3 15.2 25.0 33.0 40.3 52.3

FEMALES MEAN 5.8 8.5 13.0 22.1 29.9 36.6 45.7
26533-02 M 7.5 11.0 NA NA NA NA NA

26533-03 M 7.3 10.5 16.5 26.8 35.1 42.7 59.6
26533-04 M 7.7 11.2 NA NA NA NA NA
26533-05 M 7.5 10.6 17.0 27.0 33.8 42.0 60.9
26533-06 M 7.7 11.7 18.6 28.6 35.7 44.8 62.8
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26533-07 M 7.3 10.8 17.6 27.2 35.4 42.8 60.3
26533-08 F 6.9 10.3 17.0 27.4 34.7 41.8 60.7
26533-09 F 7.2 9.9 16.6 26.6 35.2 43.5 62.1
26533-10 F 7.4 10.9 NA NA NA NA NA
26533-11 F 6.3 9.2 NA NA NA NA NA
26533-12 F 7.4 11.2 18.0 27.9 36.6 44.1 61.4
26533-13 F 7.1 10.6 NA NA NA NA NA
26533-14 F 7.1 10.4 16.9 26.9 35.3 43.7 59.8
26533-15 F 6.9 10.4 NA NA NA NA NA
Page 1376 of 4796
MALES MEAN 7.5 11.0 17.4 27.4 35.0 43.1 60.9

FEMALES MEAN 7.0 10.4 17.1 27.2 35.5 43.3 61.0
26502-04 M 8.6 11.8 18.7 27.2 35.4 43.5 59.2

26502-05 M 6.8 9.6 16.1 25.0 32.7 40.9 57.3
26502-06 M 8.0 11.4 NA NA NA NA NA
26502-07 M 7.8 10.7 NA NA NA NA NA
26502-08 M 8.0 11.3 NA NA NA NA NA
26502-09 M 8.6 11.2 18.8 29.9 39.0 49.0 66.6
26502-10 M 8.2 11.8 19.2 29.6 38.3 46.7 62.4
26502-11 F 7.1 9.9 16.3 25.1 31.9 38.9 47.0
26502-12 F 7.2 10.2 16.2 24.0 30.4 38.1 52.2
26502-13 F 7.1 10.2 16.3 25.5 32.3 39.6 55.4
26502-15 F 7.2 10.4 17.3 26.2 34.3 43.0 59.0
26502-16 F 7.6 10.2 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26502-17 F 6.9 10.0 NA NA NA NA NA
MALES MEAN 8.0 11.1 18.2 27.9 36.4 45.0 61.4

FEMALES MEAN 7.2 10.2 16.5 25.2 32.2 39.9 53.4
26451-02 M 8.1 10.7 18.0 26.7 35.2 43.0 57.8

26451-03 M 7.2 9.3 NA NA NA NA NA
26451-04 M 8.2 11.1 17.5 27.4 34.7 41.7 56.1
26451-05 M 7.5 10.1 NA NA NA NA NA
26451-06 M 8.5 11.3 19.2 29.9 38.5 47.3 62.1
Page 1377 of 4796
26451-07 M 7.7 10.5 17.1 24.7 31.2 39.5 53.0

26451-09 F 8.0 10.3 NA NA NA NA NA
26451-10 F 7.3 9.8 16.3 25.5 32.5 39.9 54.1
26451-11 F 6.8 9.0 15.0 24.0 31.5 40.8 51.1
26451-12 F 7.6 10.4 16.5 25.7 33.7 42.0 54.7
26451-13 F 7.0 9.8 15.7 22.5 28.5 36.1 50.4
26451-14 F 7.0 9.2 NA NA NA NA NA
26451-15 F 7.9 10.2 NA NA NA NA NA
26451-16 F 6.9 9.0 NA NA NA NA NA
26451-17 F 7.4 9.4 NA NA NA NA NA
MALES MEAN 7.9 10.5 18.0 27.2 34.9 42.9 57.3

FEMALES MEAN 7.3 9.7 15.9 24.4 31.6 39.7 52.6
26535-01 M 6.5 9.5 NA NA NA NA NA

26535-02 M 7.2 9.4 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26535-03 M 7.1 9.8 15.8 24.2 31.9 39.3 49.2
26535-04 M 6.2 9.1 15.0 22.4 30.6 36.6 48.3
26535-05 M 6.7 9.5 15.4 21.9 29.7 34.2 43.2
26535-06 M 6.5 9.1 NA NA NA NA NA
26535-07 M 7.1 10.1 NA NA NA NA NA
26535-08 M 7.0 8.9 15.1 24.2 31.5 37.3 51.0
26535-09 M 5.5 8.2 NA NA NA NA NA
26535-10 F 6.2 8.9 NA NA NA NA NA
26535-11 F 6.4 9.3 14.4 21.3 29.6 34.6 42.0
26535-12 F 6.0 8.0 NA NA NA NA NA
Page 1378 of 4796
26535-13 F 6.0 7.8 13.6 20.9 27.8 33.5 43.1

26535-14 F 6.4 9.1 14.6 22.1 29.3 33.3 45.0
26535-15 F 6.0 9.3 NA NA NA NA NA
26535-16 F 5.9 8.2 12.8 20.7 28.5 33.6 42.5
26535-17 M 6.6 9.0 NA NA NA NA NA
MALES MEAN 6.6 9.3 15.3 23.2 30.9 36.9 47.9

FEMALES MEAN 6.1 8.7 13.9 21.3 28.8 33.8 43.2
26456-01 M 6.8 9.7 16.7 26.0 34.2 43.4 57.2

26456-02 M 6.8 9.4 NA NA NA NA NA
26456-03 M 7.6 10.6 NA NA NA NA NA
26456-04 M 6.9 9.5 NA NA NA NA NA
26456-05 M 6.9 9.7 15.8 25.5 32.9 40.6 53.2
26456-06 M 6.9 9.9 NA NA NA NA NA
26456-07 M 6.5 9.6 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26456-08 M 7.0 9.7 16.5 25.7 33.7 39.9 52.6
26456-09 M 6.5 9.8 NA NA NA NA NA
26456-10 M 6.8 9.2 NA NA NA NA NA
26456-11 M 6.1 8.4 13.7 21.8 28.7 34.0 43.7
26456-12 M 7.0 8.6 NA NA NA NA NA
26456-13 F 6.1 8.3 NA NA NA NA NA
26456-14 F 6.8 9.2 15.5 23.9 31.4 40.4 53.3
26456-15 F 6.7 9.4 16.0 25.0 32.7 41.7 55.4
26456-16 F 6.3 8.7 15.1 24.6 32.5 40.5 54.4
26456-17 F 6.9 9.8 NA NA NA NA NA
Page 1379 of 4796
26456-18 F 6.4 8.9 15.2 24.2 30.7 36.5 48.6
MALES MEAN 6.8 9.5 15.7 24.8 32.4 39.5 51.7

FEMALES MEAN 6.5 9.1 15.5 24.4 31.8 39.8 52.9
26518-01 M 8.4 12.4 NA NA NA NA NA

26518-02 M 8.0 11.2 17.8 28.3 38.0 45.1 61.8
26518-03 M 7.8 11.1 17.6 28.4 36.9 44.8 61.0
26518-04 M 8.0 11.4 18.0 28.7 37.0 45.1 60.0
26518-05 M 8.0 12.1 NA NA NA NA NA
26518-06 M 8.1 11.8 17.9 28.3 35.6 41.4 58.1
26518-07 F 7.8 11.5 18.0 28.6 36.9 43.6 58.7
26518-08 F 7.0 7.9 12.4 21.7 28.4 34.1 46.4
26518-09 F 7.4 11.3 NA NA NA NA NA
26518-10 F 7.9 11.4 17.5 28.3 36.3 42.7 58.6
26518-11 F 7.7 11.0 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26518-12 F 7.9 11.0 16.5 27.4 35.6 43.1 55.7
MALES MEAN 8.1 11.7 17.8 28.4 36.9 44.1 60.2

FEMALES MEAN 7.6 10.7 16.1 26.5 34.3 40.9 54.9
26459-04 M 7.7 12.6 20.2 32.4 41.7 50.8 67.8

26459-05 M 7.9 12.4 19.7 31.4 40.6 47.4 61.3
26459-06 M 8.2 12.8 20.3 31.3 40.6 49.4 61.8
26459-07 M 9.1 14.0 22.3 33.1 43.5 52.6 66.4
26459-08 F 8.6 13.2 NA NA NA NA NA
Page 1380 of 4796
26459-09 F 7.7 12.3 19.4 30.3 39.3 48.2 61.2

26459-10 F 8.3 13.0 21.0 32.1 42.6 51.1 66.8
26459-11 F 6.2 8.9 15.0 24.9 33.6 40.7 52.1
26459-12 F 8.3 12.8 20.1 31.4 40.6 49.2 63.6
26459-13 F 7.3 11.6 NA NA NA NA NA
MALES MEAN 8.2 13.0 20.6 32.1 41.6 50.1 64.3

FEMALES MEAN 7.7 12.0 18.9 29.7 39.0 47.3 60.9
MALES MEAN 7.4 10.2 16.6 26.1 34.0 41.6 54.4

S.D. 0.70 1.15 1.64 2.57 2.93 3.49 5.23
S.E. 0.14 0.23 0.35 0.55 0.62 0.74 1.12
N 24 24 22 22 22 22 22
FEMALES MEAN 7.0 9.6 15.4 24.6 32.2 39.5 51.1

S.D. 0.68 1.05 1.54 2.59 2.99 3.67 5.35
S.E. 0.14 0.21 0.33 0.55 0.64 0.78 1.14
N 24 24 22 22 22 22 22
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23198-01 M 7.5 10.8 17.5 27.0 34.6 42.4 56.3
23198-02 M 7.9 10.6 NA NA NA NA NA
23198-03 M 7.5 9.7 NA NA NA NA NA
23198-04 M 8.1 11.4 NA NA NA NA NA
23198-05 M 8.2 10.9 NA NA NA NA NA
23198-06 M 8.5 11.8 18.5 27.9 35.5 44.3 61.3
23198-07 M 7.1 9.9 16.4 25.3 32.8 39.5 51.1
23198-08 M 7.7 10.9 17.9 27.2 34.4 40.4 56.0
23198-09 F 7.1 9.4 NA NA NA NA NA
23198-10 F 8.3 10.6 NA NA NA NA NA
Page 1381 of 4796
23198-11 F 6.2 8.3 13.8 22.1 29.8 37.0 50.6

23198-12 F 7.3 9.6 15.8 23.6 30.0 37.0 50.2
23198-13 F 6.8 9.2 NA NA NA NA NA
23198-14 F 6.3 8.0 12.5 19.5 24.9 32.0 41.1
23198-15 F 7.5 10.2 16.4 25.2 31.7 38.7 53.8
MALES MEAN 7.8 10.8 17.6 26.9 34.3 41.7 56.2

FEMALES MEAN 7.1 9.3 14.6 22.6 29.1 36.2 48.9
23233-04 M 7.9 11.5 17.0 26.1 33.3 41.1 53.7

23233-05 M 6.9 10.1 14.4 21.9 30.2 37.1 49.7
23233-07 M 7.6 11.1 15.9 23.7 32.3 39.9 54.8
23233-08 M 7.2 11.3 15.2 24.0 31.7 40.3 53.9
23233-09 F 7.5 11.0 16.5 25.0 32.2 40.0 50.3
23233-10 F 7.7 11.7 17.0 25.8 34.0 41.4 54.9
23233-11 F 7.4 11.0 16.7 26.1 32.5 40.1 51.3
MALES MEAN 7.4 11.0 15.6 23.9 31.9 39.6 53.0

FEMALES MEAN 7.5 11.2 16.7 25.6 32.9 40.5 52.2
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23241-01 M 7.8 10.5 NA NA NA NA NA
23241-02 M 7.5 10.5 NA NA NA NA NA
23241-03 M 7.3 10.1 16.2 24.2 29.3 35.4 47.0
23241-04 M 7.7 10.9 17.3 26.1 30.7 35.9 49.4
23241-05 M 7.5 10.1 16.2 24.1 29.3 35.2 45.3
23241-06 M 7.6 10.5 17.1 25.1 29.5 34.4 45.8
23241-07 M 8.3 11.8 NA NA NA NA NA
23241-08 F 7.2 10.3 16.5 24.5 28.3 33.4 45.5
23241-09 F 7.3 10.2 16.4 24.9 29.3 34.5 46.9
23241-10 F 7.2 10.6 17.1 25.3 29.9 34.9 46.6
Page 1382 of 4796
23241-11 F 7.3 10.8 17.3 26.3 31.8 37.9 50.5

23241-12 F 7.4 10.5 NA NA NA NA NA
23241-13 F 7.0 9.9 NA NA NA NA NA
MALES MEAN 7.7 10.6 16.7 24.9 29.7 35.2 46.9

FEMALES MEAN 7.2 10.4 16.8 25.3 29.8 35.2 47.4
23254-01 M 5.9 8.1 NA NA NA NA NA

23254-02 M 8.2 10.9 NA NA NA NA NA
23254-03 F 6.5 9.0 NA NA NA NA NA
23254-04 F 7.5 10.5 NA NA NA NA NA
23254-05 F 7.5 10.0 NA NA NA NA NA
23254-06 F 7.1 10.1 NA NA NA NA NA
23254-07 F 8.8 11.1 NA NA NA NA NA
23254-08 F 7.0 9.8 NA NA NA NA NA
23254-09 F 7.4 10.0 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23254-10 F 7.9 10.4 NA NA NA NA NA
23254-11 F 7.8 10.0 NA NA NA NA NA
MALES MEAN 7.1 9.5

23239-02 M 7.7 10.7 17.6 27.9 35.7 45.2 54.9

23239-03 M 7.7 11.3 18.4 29.3 38.3 47.4 59.4
23239-04 M 7.6 11.1 17.3 28.1 37.8 47.2 57.6
23239-05 M 7.2 10.0 17.1 27.4 35.5 43.9 54.9
Page 1383 of 4796
23239-06 F 7.0 10.3 NA NA NA NA NA

23239-07 F 6.7 9.5 NA NA NA NA NA
23239-08 F 7.6 11.0 18.8 29.7 38.2 47.5 57.5
23239-09 F 7.6 11.9 19.0 29.8 38.6 48.6 61.9
23239-10 F 7.1 9.8 16.5 26.9 35.5 44.0 48.6
23239-11 F 7.4 9.9 NA NA NA NA NA
23239-12 F 7.5 11.6 NA NA NA NA NA
23239-13 F 7.3 10.9 18.0 28.9 37.1 45.2 55.0
MALES MEAN 7.6 10.8 17.6 28.2 36.8 45.9 56.7

FEMALES MEAN 7.3 10.6 18.1 28.8 37.4 46.3 55.8
23245-02 M 6.0 8.4 13.5 21.2 29.3 35.7 45.7

23245-03 M 6.2 8.9 13.9 21.3 28.6 35.7 45.4
23245-04 M 6.2 8.9 14.9 23.0 29.6 32.2 45.7
23245-05 M 5.9 8.8 14.5 22.0 28.6 34.7 44.8
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23245-06 F 5.9 8.5 NA NA NA NA NA
23245-07 F 6.2 8.8 14.1 22.0 29.5 35.9 46.9
23245-08 F 6.3 8.7 NA NA NA NA NA
23245-09 F 6.1 8.6 NA NA NA NA NA
23245-10 F 5.9 8.5 13.9 21.8 28.2 34.5 42.9
23245-11 F 6.0 8.6 13.8 21.2 27.7 33.4 42.6
23245-12 F 5.6 8.1 NA NA NA NA NA
23245-13 F 6.4 9.2 NA NA NA NA NA
23245-14 F 5.9 8.4 13.1 20.7 27.2 35.6 42.3
Page 1384 of 4796
MALES MEAN 6.1 8.8 14.2 21.9 29.0 34.6 45.4

FEMALES MEAN 6.0 8.6 13.7 21.4 28.2 34.9 43.7
23223-01 M 7.9 10.5 NA NA NA NA NA

23223-02 M 8.5 10.4 16.9 26.2 33.7 41.0 53.7
23223-03 M 8.8 11.4 NA NA NA NA NA
23223-04 M 8.8 11.3 NA NA NA NA NA
23223-05 M 8.2 10.2 16.0 25.1 35.1 43.6 55.4
23223-06 M 8.1 10.5 17.9 26.8 35.8 45.2 55.1
23223-07 M 7.6 9.2 NA NA NA NA NA
23223-08 M 8.3 11.6 17.9 27.0 37.2 46.0 58.3
23223-09 M 9.0 11.4 NA NA NA NA NA
23223-10 M 7.0 9.3 NA NA NA NA NA
23223-11 F 8.3 11.0 17.9 27.2 35.2 45.3 62.1
23223-12 F 7.7 10.0 NA NA NA NA NA
23223-13 F 8.5 10.9 17.8 24.3 35.1 43.6 54.3
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23223-14 F 7.8 10.0 NA NA NA NA NA
23223-15 F 7.0 9.8 15.1 26.8 33.2 40.5 50.9
23223-16 F 7.3 9.1 15.1 23.1 32.0 39.5 49.9
MALES MEAN 8.2 10.6 17.2 26.3 35.5 44.0 55.6

FEMALES MEAN 7.8 10.1 16.5 25.4 33.9 42.2 54.3
23191-01 M 6.8 9.7 17.5 28.8 35.7 40.3 51.6

23191-03 M 6.9 9.9 NA NA NA NA NA
23191-04 M 6.1 8.7 15.7 26.4 35.3 44.5 52.6
Page 1385 of 4796
23191-05 M 6.4 8.9 NA NA NA NA NA

23191-06 M 6.4 9.1 16.0 26.6 34.8 40.1 52.7
23191-07 M 6.8 9.1 NA NA NA NA NA
23191-08 M 6.5 9.4 NA NA NA NA NA
23191-09 M 6.3 9.1 16.8 27.1 35.4 44.2 55.9
23191-10 F 6.4 9.1 NA NA NA NA NA
23191-11 F 6.2 8.9 15.6 26.3 34.0 40.1 48.4
23191-12 F 6.3 8.4 15.0 26.0 34.2 40.6 49.8
23191-13 F 6.3 9.1 NA NA NA NA NA
23191-14 F 5.6 7.5 13.3 23.1 32.3 39.7 49.2
23191-15 F 5.9 7.4 13.6 22.6 29.8 35.3 44.0
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23191-16 F 5.6 7.9 NA NA NA NA NA
MALES MEAN 6.5 9.2 16.5 27.2 35.3 42.3 53.2

FEMALES MEAN 6.0 8.3 14.4 24.5 32.6 38.9 47.9
23247-01 M 6.6 9.2 NA NA NA NA NA

23247-02 M 6.7 9.6 16.0 25.0 33.3 42.4 54.4
23247-03 M 7.3 10.2 NA NA NA NA NA
23247-04 M 5.9 8.1 NA NA NA NA NA
23247-05 M 6.5 9.9 16.2 25.4 32.7 40.1 53.6
Page 1386 of 4796
23247-06 M 6.5 9.5 16.0 26.8 31.1 38.6 49.8

23247-07 M 7.4 10.5 17.3 24.6 33.7 38.9 50.5
23247-08 M 7.0 9.3 NA NA NA NA NA
23247-09 F 6.6 10.0 NA NA NA NA NA
23247-10 F 6.2 8.3 NA NA NA NA NA
23247-11 F 6.5 8.9 NA NA NA NA NA
23247-12 F 6.9 10.0 15.8 24.3 32.0 38.7 51.5
23247-13 F 6.9 9.9 16.3 25.1 30.9 37.2 47.8
23247-14 F 6.7 9.4 NA NA NA NA NA
23247-15 F 5.9 7.6 12.5 21.6 28.7 36.7 46.6
23247-16 F 7.3 10.5 17.2 26.2 34.7 42.2 53.2
MALES MEAN 6.7 9.5 16.4 25.5 32.7 40.0 52.1

FEMALES MEAN 6.6 9.3 15.5 24.3 31.6 38.7 49.8
23230-01 M 5.8 6.4 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23230-02 M 5.9 7.2 NA NA NA NA NA
23230-03 M 5.4 6.1 9.4 16.1 21.7 25.0 30.7
23230-04 M 5.2 6.2 NA NA NA NA NA
23230-05 M 6.0 7.1 11.3 17.9 25.2 31.2 36.9
23230-06 M 5.3 6.1 9.2 15.4 22.0 27.0 32.4
23230-07 M 5.7 6.7 10.5 17.4 25.2 32.2 39.0
23230-08 M 5.6 6.1 NA NA NA NA NA
23230-10 F 5.9 7.1 10.8 17.4 23.1 27.9 34.8
23230-11 F 5.5 6.1 8.8 12.5 18.4 23.8 30.5
Page 1387 of 4796
23230-12 F 5.5 6.7 10.2 17.1 20.9 24.9 29.3

23230-13 F 6.0 7.1 NA NA NA NA NA
23230-14 F 5.7 6.8 NA NA NA NA NA
23230-15 F 5.1 5.8 8.3 13.5 19.8 26.5 32.6
23230-16 F 5.8 7.1 NA NA NA NA NA
MALES MEAN 5.6 6.5 10.1 16.7 23.5 28.9 34.8

FEMALES MEAN 5.7 6.7 9.5 15.1 20.6 25.8 31.8
23249-03 M 8.5 11.7 17.8 21.3 24.3 30.5 39.1

23249-04 M 7.9 11.2 17.6 19.1 NA NA NA
23249-05 M 8.2 11.3 16.6 18.2 NA NA NA
23249-06 M 7.7 10.2 16.0 15.6 NA NA NA
23249-07 M 7.7 10.4 NA NA NA NA NA
23249-08 M 7.9 10.1 NA NA NA NA NA
23249-09 M 7.5 10.0 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23249-10 M 7.9 10.7 16.4 16.9 NA NA NA
23249-11 F 7.3 10.0 15.5 17.3 19.3 24.8 29.7
23249-12 F 7.6 10.6 16.0 20.1 22.5 27.7 37.5
23249-13 F 7.7 10.3 15.6 18.3 21.7 26.4 35.7
MALES MEAN 7.9 10.7 16.9 18.2 24.3 30.5 39.1

FEMALES MEAN 7.5 10.3 15.7 18.6 21.2 26.3 34.3
23258-01 M 7.3 9.4 14.1 20.8 23.6 29.2 37.2

23258-02 M 6.6 8.3 13.3 19.1 22.4 30.1 35.6
Page 1388 of 4796
23258-03 M 6.6 8.8 13.4 21.4 23.1 28.6 37.3

23258-04 M 5.7 7.3 NA NA NA NA NA
23258-05 M 5.3 7.1 10.5 15.3 17.4 23.5 30.7
23258-06 M 7.2 9.6 NA NA NA NA NA
23258-07 M 6.7 8.3 NA NA NA NA NA
23258-08 F 6.0 7.6 10.8 13.6 16.1 20.8 27.1
23258-09 F 5.8 7.1 NA NA NA NA NA
23258-10 F 7.0 9.1 15.0 21.0 24.4 30.3 37.7
23258-11 F 6.1 8.0 13.0 19.4 21.2 26.8 33.5
23258-12 F 6.1 6.8 NA NA NA NA NA
MALES MEAN 6.5 8.4 12.8 19.2 21.6 27.9 35.2

FEMALES MEAN 6.2 7.7 12.9 18.0 20.6 26.0 32.8
26485-01 M 6.5 10.3 NA NA NA NA NA

26485-02 M 6.3 9.0 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26485-03 M 6.3 9.5 NA NA NA NA NA
26485-04 M 6.4 9.6 NA NA NA NA NA
26485-05 M 6.5 9.8 NA NA NA NA NA
26485-06 M 6.5 9.7 NA NA NA NA NA
26485-07 M 6.5 9.6 NA NA NA NA NA
26485-08 M 6.7 9.8 NA NA NA NA NA
26485-09 M 7.0 10.5 NA NA NA NA NA
26485-10 M 6.8 10.3 NA NA NA NA NA
26485-11 M 6.9 10.6 NA NA NA NA NA
26485-12 M 6.3 9.8 NA NA NA NA NA
Page 1389 of 4796
26485-13 F 6.1 9.3 NA NA NA NA NA

26485-14 F 6.0 8.9 NA NA NA NA NA
MALES MEAN 6.6 9.9

26478-01 M 8.2 12.0 18.4 27.4 36.4 42.6 59.2

26478-02 M 7.7 11.3 18.1 26.7 35.2 41.8 57.0
26478-03 M 8.4 11.7 18.2 27.1 34.3 40.0 57.9
26478-04 M 8.2 11.4 18.2 27.5 35.0 40.3 56.9
26478-05 F 8.2 11.5 NA NA NA NA NA
26478-06 F 7.8 11.4 NA NA NA NA NA
26478-07 F 7.6 11.5 18.3 27.4 34.9 42.5 55.6
26478-08 F 8.0 11.8 18.3 27.1 35.2 42.2 58.2
26478-09 F 7.7 11.1 17.4 25.9 32.9 37.0 54.0
26478-10 F 7.3 10.7 16.8 26.4 34.1 41.2 54.9
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26478-11 F 8.3 11.4 NA NA NA NA NA
26478-12 F 7.8 11.5 NA NA NA NA NA
MALES MEAN 8.1 11.6 18.2 27.2 35.2 41.2 57.8

FEMALES MEAN 7.8 11.4 17.7 26.7 34.3 40.7 55.7
26501-01 M 6.3 9.1 NA NA NA NA NA

26501-02 M 6.6 5.9 NA NA NA NA NA
26501-03 M 7.2 9.8 15.2 24.1 33.0 40.4 51.8
26501-04 M 6.4 9.1 NA NA NA NA NA
Page 1390 of 4796
26501-05 M 6.3 8.9 NA NA NA NA NA

26501-06 M 6.9 9.7 15.1 22.6 30.1 36.4 49.7
26501-07 M 7.1 9.6 15.4 22.4 30.4 37.4 51.5
26501-08 M 6.8 9.5 16.7 24.8 31.5 37.6 52.1
26501-09 M 6.2 9.1 NA NA NA NA NA
26501-10 F 6.3 8.5 13.8 20.4 28.3 35.9 47.2
26501-11 F 6.0 7.8 NA NA NA NA NA
26501-12 F 6.7 9.1 NA NA NA NA NA
26501-13 F 6.1 8.5 NA NA NA NA NA
26501-14 F 6.0 8.5 NA NA NA NA NA
26501-15 F 6.4 9.1 14.8 23.6 31.4 38.7 46.5
26501-16 F 6.0 8.1 13.2 20.4 26.8 32.9 45.7
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26501-17 F 5.9 8.8 14.1 21.7 30.0 37.1 50.5
MALES MEAN 6.6 9.0 15.6 23.5 31.3 38.0 51.3

FEMALES MEAN 6.2 8.6 14.0 21.5 29.1 36.2 47.5
26486-01 M 7.5 9.6 16.0 25.0 31.9 38.0 49.9

26486-02 M 7.1 9.7 16.6 25.4 32.7 39.2 50.4
26486-03 M 7.0 9.3 15.1 23.4 30.9 37.8 49.7
26486-04 M 7.0 8.4 NA NA NA NA NA
26486-05 M 7.3 9.1 15.3 24.3 31.5 38.9 48.9
Page 1391 of 4796
26486-06 M 8.0 10.4 NA NA NA NA NA

26486-07 M 7.5 9.2 NA NA NA NA NA
26486-08 F 6.8 8.6 13.7 22.5 29.9 36.9 48.0
26486-09 F 6.9 8.7 NA NA NA NA NA
26486-10 F 7.4 9.9 15.7 25.0 32.1 39.7 54.5
26486-11 F 7.3 9.2 NA NA NA NA NA
26486-12 F 7.5 9.3 NA NA NA NA NA
26486-13 F 6.6 8.8 14.7 23.7 31.0 37.9 54.0
26486-14 F 6.4 8.1 12.9 20.9 27.7 33.5 44.0
MALES MEAN 7.3 9.4 15.8 24.5 31.8 38.5 49.7

FEMALES MEAN 7.0 8.9 14.3 23.0 30.2 37.0 50.1
26464-01 M 7.9 10.3 NA NA NA NA NA

26464-02 M 7.7 10.0 16.9 26.5 35.8 43.9 56.6
26464-03 M 8.2 10.6 16.8 26.9 34.8 42.3 53.2
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26464-04 M 7.7 9.2 NA NA NA NA NA
26464-05 M 8.0 10.8 17.6 27.9 35.9 44.4 56.7
26464-06 M 8.4 10.4 16.2 25.9 32.9 39.9 49.6
26464-07 M 7.8 10.2 NA NA NA NA NA
26464-08 F 7.2 9.3 14.4 23.3 29.7 38.9 46.0
26464-09 F 7.3 9.4 15.1 24.3 31.7 41.2 51.6
26464-10 F 7.5 9.5 15.2 24.2 32.0 38.7 47.9
26464-11 F 7.5 10.5 15.9 26.0 33.9 42.4 54.4
26464-12 F 6.9 9.1 NA NA NA NA NA
26464-13 F 6.8 8.9 NA NA NA NA NA
Page 1392 of 4796
MALES MEAN 8.0 10.2 16.9 26.8 34.9 42.6 54.0

FEMALES MEAN 7.2 9.5 15.2 24.5 31.8 40.3 50.0
26498-01 M 6.2 8.1 NA NA NA NA NA

26498-02 M 6.6 8.9 NA NA NA NA NA
26498-03 M 6.5 8.5 14.1 21.6 28.5 36.5 49.4
26498-04 M 6.4 8.3 14.0 21.4 30.1 37.0 49.7
26498-05 M 6.1 7.9 13.9 21.7 29.8 36.7 48.3
26498-06 M 6.2 8.5 15.2 23.1 31.1 39.4 52.7
26498-07 F 6.3 8.2 NA NA NA NA NA
26498-08 F 6.4 8.4 NA NA NA NA NA
26498-09 F 6.5 8.7 14.7 23.4 31.6 39.3 50.9
26498-10 F 6.1 8.3 NA NA NA NA NA
26498-11 F 5.7 7.8 NA NA NA NA NA
26498-12 F 6.3 8.5 13.4 23.2 30.6 38.1 50.6
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26498-13 F 6.3 8.1 NA NA NA NA NA
26498-14 F 6.2 8.0 14.7 22.4 30.9 37.6 48.8
26498-15 F 5.8 7.6 13.4 20.6 28.7 34.5 47.2
26498-16 F 5.9 7.8 NA NA NA NA NA
MALES MEAN 6.3 8.4 14.3 22.0 29.9 37.4 50.0

FEMALES MEAN 6.2 8.1 14.1 22.4 30.5 37.4 49.4
26481-01 M 7.0 9.3 15.8 24.6 32.5 41.0 56.0

26481-02 M 6.9 9.0 NA NA NA NA NA
Page 1393 of 4796
26481-03 M 7.1 9.3 15.6 24.1 31.8 40.8 56.1

26481-04 M 7.9 10.1 NA NA NA NA NA
26481-05 M 6.8 8.8 NA NA NA NA NA
26481-06 M 7.3 9.7 16.7 26.2 34.5 42.6 59.7
26481-07 M 6.6 9.0 15.2 24.7 32.0 40.4 56.3
26481-08 F 6.6 8.0 14.6 23.0 32.5 40.9 56.3
26481-09 F 7.1 8.8 NA NA NA NA NA
26481-10 F 7.9 10.4 NA NA NA NA NA
26481-11 F 7.1 9.7 17.1 26.7 35.7 43.8 62.2
26481-12 F 7.0 9.0 NA NA NA NA NA
26481-13 F 7.3 10.2 17.1 27.6 36.7 44.1 61.7
26481-14 F 7.6 10.0 NA NA NA NA NA
26481-15 F 6.5 8.3 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26481-16 F 6.4 8.4 14.3 22.4 29.3 37.0 51.9
MALES MEAN 7.1 9.3 15.8 24.9 32.7 41.2 57.0

FEMALES MEAN 7.1 9.2 15.8 24.9 33.6 41.5 58.0
26472-02 F 5.7 7.5 12.9 22.0 29.3 38.9 47.7

26472-03 M 6.1 8.3 NA NA NA NA NA
26472-04 M 6.0 8.1 NA NA NA NA NA
26472-05 M 6.1 8.3 NA NA NA NA NA
26472-06 M 5.9 7.4 12.6 20.9 29.4 38.3 50.8
Page 1394 of 4796
26472-07 M 6.9 9.2 NA NA NA NA NA

26472-08 M 6.1 8.0 13.6 21.8 29.6 39.3 46.4
26472-09 M 6.1 8.1 NA NA NA NA NA
26472-10 M 5.9 8.1 14.2 22.7 30.1 36.1 47.8
26472-11 M 6.2 8.3 NA NA NA NA NA
26472-12 M 6.1 7.9 13.3 21.9 30.2 38.3 47.7
26472-13 F 5.6 8.0 13.4 21.2 29.6 38.5 48.9
26472-14 F 6.2 7.9 13.7 22.1 28.6 36.7 47.7
26472-15 F 6.2 8.7 14.7 23.4 31.8 41.0 51.0
26472-16 F 6.0 7.9 NA NA NA NA NA
26472-17 F 5.9 7.9 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26472-18 F 5.8 8.1 NA NA NA NA NA
MALES MEAN 6.1 8.2 13.4 21.8 29.8 38.0 48.2

FEMALES MEAN 5.9 8.0 13.7 22.2 29.8 38.8 48.8
26537-01 M 7.4 9.9 16.5 25.7 35.5 42.9 52.9

26537-02 M 6.4 8.8 NA NA NA NA NA
26537-03 M 6.9 9.4 NA NA NA NA NA
26537-04 M 7.3 10.2 16.4 26.4 35.0 40.8 52.3
26537-05 M 5.9 7.7 NA NA NA NA NA
Page 1395 of 4796
26537-06 M 6.3 8.4 NA NA NA NA NA

26537-07 M 6.4 9.1 NA NA NA NA NA
26537-08 M 6.9 9.2 15.7 26.0 35.2 43.4 52.1
26537-09 F 6.1 7.3 11.3 20.5 26.2 34.2 42.0
26537-10 F 6.8 9.0 15.2 25.4 32.9 40.8 51.3
26537-11 F 6.6 8.8 14.5 24.7 32.8 39.8 49.1
26537-12 F 6.2 8.0 NA NA NA NA NA
26537-13 M 7.2 9.9 15.7 25.9 32.6 40.2 50.6
26537-14 F 6.0 7.9 NA NA NA NA NA
26537-15 F 6.0 8.0 13.6 22.5 30.7 36.4 43.9
26537-16 F 5.8 7.6 NA NA NA NA NA
MALES MEAN 6.7 9.2 16.1 26.0 34.6 41.8 52.0

FEMALES MEAN 6.2 8.1 13.7 23.3 30.7 37.8 46.6
26506-01 M 6.6 9.2 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26506-02 M 6.9 9.6 16.3 27.9 38.1 45.8 58.5
26506-03 M 6.1 8.5 15.0 24.2 34.1 41.4 52.6
26506-04 M 6.4 9.0 15.3 25.0 34.1 43.3 54.5
26506-05 M 6.6 9.2 15.2 26.9 35.6 43.8 51.7
26506-06 F 6.1 8.1 NA NA NA NA NA
26506-07 F 6.3 8.8 NA NA NA NA NA
26506-08 F 5.8 8.3 NA NA NA NA NA
26506-09 F 6.6 9.4 15.2 26.8 35.7 42.6 54.7
26506-11 F 5.6 7.4 NA NA NA NA NA
Page 1396 of 4796
26506-12 F 6.3 9.3 15.8 27.4 36.7 46.6 58.6

26506-13 F 6.8 9.4 16.0 28.1 38.9 46.9 56.3
26506-14 F 6.1 8.8 NA NA NA NA NA
26506-15 F 4.4 5.5 NA NA NA NA NA
26506-16 F 6.6 9.1 NA NA NA NA NA
26506-17 F 6.0 8.2 14.5 25.1 34.9 45.3 56.1
MALES MEAN 6.5 9.1 15.5 26.0 35.5 43.6 54.3

FEMALES MEAN 6.0 8.4 15.4 26.9 36.6 45.4 56.4
26471-01 M 7.0 9.9 NA NA NA NA NA

26471-02 M 7.2 10.3 16.0 26.0 33.5 40.4 52.7
26471-03 M 6.6 9.6 NA NA NA NA NA
26471-04 M 6.9 9.3 NA NA NA NA NA
26471-05 M 7.5 10.2 NA NA NA NA NA
26471-06 M 7.0 9.9 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26471-07 M 7.0 9.9 16.4 25.8 33.8 42.5 56.2
26471-08 M 7.4 10.4 17.2 27.5 35.9 43.5 56.2
26471-09 M 6.5 9.0 15.6 25.6 33.3 39.9 50.6
26471-10 F 7.0 9.8 16.4 26.4 34.0 39.9 52.1
26471-11 F 6.7 9.6 15.8 24.6 33.3 40.0 53.2
26471-12 F 6.9 9.6 NA NA NA NA NA
26471-13 F 6.7 9.3 15.7 25.8 33.7 40.9 52.2
26471-14 F 6.4 9.0 15.3 24.5 31.8 40.1 49.5
MALES MEAN 7.0 9.8 16.3 26.2 34.1 41.6 53.9

Page 1397 of 4796
FEMALES MEAN 6.7 9.5 15.8 25.3 33.2 40.2 51.8
26455-01 M 8.3 9.9 15.1 24.6 30.1 36.2 50.4

26455-02 M 7.9 9.6 14.5 23.7 30.9 37.7 48.4
26455-03 M 8.7 10.0 NA NA NA NA NA
26455-04 M 7.5 8.6 NA NA NA NA NA
26455-05 M 7.2 9.2 14.3 23.4 29.9 37.1 46.9
26455-06 M 7.9 9.3 13.8 21.9 29.4 35.5 49.7
26455-07 F 7.7 9.5 NA NA NA NA NA
26455-08 F 7.3 8.2 NA NA NA NA NA
26455-09 F 7.0 8.9 13.2 22.8 29.8 36.0 47.7
26455-10 F 7.0 8.0 11.7 20.0 25.4 29.7 42.4
26455-11 F 6.9 7.9 12.0 20.6 27.3 33.5 43.4
26455-12 F 7.1 8.7 14.0 22.6 29.1 34.9 46.3
26455-13 F 7.6 9.0 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26455-14 F 7.2 8.7 NA NA NA NA NA
MALES MEAN 7.9 9.4 14.4 23.4 30.1 36.6 48.9

FEMALES MEAN 7.2 8.6 12.7 21.5 27.9 33.5 45.0
MALES MEAN 7.1 9.6 15.6 24.1 31.6 38.7 50.2

S.D. 0.73 1.12 1.85 3.09 4.13 4.83 6.57
S.E. 0.15 0.23 0.40 0.66 0.88 1.03 1.40
N 24 24 22 22 22 22 22
Page 1398 of 4796
FEMALES MEAN 6.8 9.2 14.9 23.3 30.3 37.3 48.1

S.D. 0.67 1.15 1.89 3.15 4.57 5.53 7.20
S.E. 0.14 0.23 0.40 0.67 0.97 1.18 1.53
N 24 24 22 22 22 22 22
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23255-01 M 6.2 7.4 NA NA NA NA NA
23255-02 M 6.0 6.9 11.0 18.8 24.8 32.6 40.9
23255-03 M 5.7 6.7 NA NA NA NA NA
23255-04 M 5.9 7.1 11.0 18.4 25.7 32.0 40.2
23255-05 M 5.3 6.3 10.2 17.1 23.1 29.8 37.3
23255-06 M 6.1 7.2 NA NA NA NA NA
23255-07 M 5.8 7.0 NA NA NA NA NA
23255-08 M 6.1 7.4 11.9 19.0 27.0 32.8 41.9
23255-09 M 5.7 6.4 NA NA NA NA NA
23255-10 M 6.2 7.0 NA NA NA NA NA
Page 1399 of 4796
23255-11 F 5.0 6.1 9.5 16.9 24.3 31.7 39.1

23255-12 F 5.6 7.2 11.3 19.1 27.4 34.6 43.1
23255-13 F 5.2 5.9 NA NA NA NA NA
23255-14 F 5.9 6.8 10.6 17.9 24.3 30.5 40.0
23255-15 F 5.2 6.3 NA NA NA NA NA
23255-16 F 5.6 6.6 11.4 19.8 25.5 32.7 41.5
MALES MEAN 5.9 6.9 11.0 18.3 25.2 31.8 40.1

FEMALES MEAN 5.4 6.5 10.7 18.4 25.4 32.4 40.9
23215-01 M 8.3 10.7 NA NA NA NA NA

23215-02 M 7.5 9.9 16.6 25.6 33.2 39.9 53.5
23215-03 M 7.7 9.3 15.5 24.1 33.0 39.6 48.7
23215-04 M 8.0 11.1 NA NA NA NA NA
23215-05 M 8.3 11.0 17.8 27.5 35.9 41.1 57.8
23215-06 M 7.6 9.6 16.5 24.5 32.8 39.9 52.3
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23215-07 M 7.4 9.7 NA NA NA NA NA
23215-08 M 8.7 11.2 NA NA NA NA NA
23215-09 M 8.3 10.8 NA NA NA NA NA
23215-10 F 7.3 9.3 NA NA NA NA NA
23215-11 F 7.2 9.2 15.5 23.8 32.2 39.1 51.2
23215-12 F 7.8 9.5 16.1 25.1 33.5 41.6 51.0
23215-13 F 8.6 10.4 17.3 26.0 33.4 39.7 51.2
23215-14 F 6.9 8.6 NA NA NA NA NA
23215-15 F 8.3 9.8 16.6 25.5 34.3 44.2 51.8
23215-16 F 7.2 9.6 NA NA NA NA NA
Page 1400 of 4796
MALES MEAN 8.0 10.4 16.6 25.4 33.7 40.1 53.1

FEMALES MEAN 7.6 9.5 16.4 25.1 33.4 41.2 51.3
23214-01 M 6.9 9.8 NA NA NA NA NA

23214-02 M 7.6 10.0 16.5 25.0 34.1 41.2 55.1
23214-03 M 7.2 9.3 NA NA NA NA NA
23214-04 M 6.8 9.3 NA NA NA NA NA
23214-05 M 7.4 9.6 16.0 24.1 32.6 38.8 52.1
23214-06 M 7.3 9.5 NA NA NA NA NA
23214-07 M 7.6 9.9 16.0 25.0 31.7 39.8 52.6
23214-08 M 6.3 9.0 15.0 23.4 32.1 39.6 52.1
23214-09 M 6.6 9.4 NA NA NA NA NA
23214-10 F 6.2 9.0 15.0 23.8 31.5 37.8 49.5
23214-11 F 6.5 9.6 14.7 23.0 30.2 36.9 49.0
23214-12 F 7.0 9.7 15.9 24.5 32.9 39.9 52.9
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23214-13 F 6.9 9.5 NA NA NA NA NA
23214-14 F 6.8 8.8 14.5 23.1 30.9 37.3 49.6
MALES MEAN 7.1 9.5 15.9 24.4 32.6 39.9 53.0

FEMALES MEAN 6.7 9.3 15.0 23.6 31.4 38.0 50.3
23192-01 M 7.1 9.2 13.7 21.5 28.2 33.3 42.8

23192-02 M 7.0 9.2 NA NA NA NA NA
23192-03 M 7.7 9.6 14.2 21.8 27.0 31.4 43.0
23192-04 M 6.5 8.2 NA NA NA NA NA
Page 1401 of 4796
23192-06 M 6.7 8.4 NA NA NA NA NA

23192-07 M 6.8 8.7 NA NA NA NA NA
23192-08 M 6.7 8.2 12.8 20.0 26.6 32.0 38.4
23192-09 M 6.5 8.5 13.3 20.0 26.3 30.7 39.8
23192-10 F 5.6 7.4 11.4 18.2 23.9 28.6 38.3
23192-11 F 6.4 7.8 12.0 19.1 25.6 30.2 40.3
23192-12 F 5.9 7.3 11.4 17.8 24.3 29.2 38.2
23192-13 F 5.9 7.6 12.4 19.5 26.2 31.5 40.6
MALES MEAN 6.9 8.8 13.5 20.8 27.0 31.9 41.0

FEMALES MEAN 6.0 7.5 11.8 18.7 25.0 29.9 39.4
23219-02 M 7.0 10.4 NA NA NA NA NA

23219-03 M 8.0 11.2 NA NA NA NA NA
23219-05 M 7.8 10.9 19.3 28.4 36.6 43.0 58.9
23219-06 M 7.4 10.6 17.7 27.2 36.3 44.7 59.8
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23219-07 M 7.3 10.9 NA NA NA NA NA
23219-08 M 7.5 10.5 NA NA NA NA NA
23219-09 M 7.1 10.3 NA NA NA NA NA
23219-10 M 7.5 10.8 19.2 27.4 35.0 43.4 56.5
23219-11 M 7.8 11.2 18.5 27.2 36.1 44.9 59.5
23219-12 F 6.7 9.4 16.4 24.4 31.9 37.8 50.0
23219-13 F 7.0 10.2 17.9 26.6 34.6 42.9 53.8
23219-14 F 7.4 10.3 17.3 25.9 34.1 42.7 54.8
23219-15 F 7.3 10.0 17.2 25.3 33.3 40.4 48.5
23219-16 F 7.1 10.2 NA NA NA NA NA
Page 1402 of 4796
MALES MEAN 7.5 10.8 18.7 27.6 36.0 44.0 58.7

FEMALES MEAN 7.1 10.0 17.2 25.6 33.5 41.0 51.8
23211-01 M 6.8 8.4 14.2 19.8 27.0 34.1 42.4

23211-02 M 6.5 9.0 14.9 21.1 27.3 35.0 46.6
23211-03 M 7.0 8.8 NA NA NA NA NA
23211-04 M 7.1 9.0 15.3 21.6 29.5 36.3 47.4
23211-05 M 6.9 8.6 14.2 20.2 27.3 34.7 45.6
23211-06 M 7.5 8.8 NA NA NA NA NA
23211-07 M 7.6 9.2 NA NA NA NA NA
23211-08 M 6.4 8.0 NA NA NA NA NA
23211-09 M 7.1 8.8 NA NA NA NA NA
23211-10 M 7.0 8.4 NA NA NA NA NA
23211-11 F 6.6 7.8 12.6 17.9 23.4 29.9 36.5
23211-12 F 7.0 8.5 14.0 19.5 27.5 34.1 46.0
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23211-13 F 6.5 8.3 13.5 19.1 26.7 33.3 43.5
23211-14 F 7.2 8.9 15.2 21.8 29.8 36.1 49.1
MALES MEAN 7.0 8.7 14.7 20.7 27.8 35.0 45.5

FEMALES MEAN 6.8 8.4 13.8 19.6 26.9 33.4 43.8
23189-01 M 6.0 7.2 10.2 19.5 27.3 34.4 43.3

23189-02 M 5.3 7.5 NA NA NA NA NA
23189-03 M 6.7 8.2 14.8 23.8 31.8 39.8 49.8
23189-04 M 5.8 8.0 NA NA NA NA NA
Page 1403 of 4796
23189-05 M 6.4 8.1 NA NA NA NA NA

23189-06 M 6.8 8.5 14.0 23.6 32.5 40.8 51.3
23189-07 M 5.7 7.8 12.5 22.3 31.3 38.4 46.3
23189-08 F 6.2 8.7 NA NA NA NA NA
23189-09 F 6.1 8.2 NA NA NA NA NA
23189-10 F 5.5 7.2 11.9 20.9 29.7 36.8 48.8
23189-11 F 5.6 7.6 NA NA NA NA NA
23189-12 F 5.4 6.5 10.8 18.8 27.3 34.0 43.7
23189-13 F 6.1 7.6 NA NA NA NA NA
23189-14 F 5.6 7.1 NA NA NA NA NA
23189-15 F 6.1 8.4 14.4 23.8 32.8 40.1 51.7
23189-16 F 6.6 8.7 NA NA NA NA NA
23189-17 F 5.3 6.6 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23189-18 F 4.9 6.4 11.1 17.4 24.6 31.1 38.5
MALES MEAN 6.1 7.9 12.9 22.3 30.7 38.4 47.7

FEMALES MEAN 5.8 7.5 12.1 20.2 28.6 35.5 45.7
23204-01 M 6.3 8.0 NA NA NA NA NA

23204-04 M 6.4 8.2 NA NA NA NA NA
23204-05 M 5.5 6.9 NA NA NA NA NA
23204-06 M 6.6 8.0 NA NA NA NA NA
Page 1404 of 4796
23204-07 M 6.6 8.6 NA NA NA NA NA

23204-08 M 6.6 8.1 12.8 20.7 29.1 36.9 46.6
23204-09 M 6.3 8.2 NA NA NA NA NA
23204-10 M 6.2 8.2 12.3 20.2 27.2 33.9 43.9
23204-11 M 5.8 7.5 11.6 19.6 27.0 33.4 44.0
23204-12 M 6.2 7.7 11.8 19.2 26.4 32.5 43.8
23204-14 F 6.0 7.6 11.7 16.7 24.1 30.9 41.0
23204-15 F 6.4 8.1 NA NA NA NA NA
23204-16 F 6.0 7.6 11.2 18.0 25.7 33.2 41.5
23204-17 F 5.3 6.8 10.5 16.3 22.8 28.5 37.2
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23204-18 F 6.0 7.2 11.2 17.6 25.0 31.9 40.8
MALES MEAN 6.1 7.9 12.1 19.9 27.4 34.2 44.6

FEMALES MEAN 5.9 7.5 11.2 17.2 24.4 31.1 40.1
23257-02 M 4.8 5.6 NA NA NA NA NA
23257-03 M 4.9 6.0 NA NA NA NA NA
23257-04 M 6.7 9.4 15.1 22.8 30.1 34.2 48.8
23257-05 M 6.3 8.9 15.2 24.0 33.5 41.8 51.5
Page 1405 of 4796
23257-06 M 6.3 8.8 15.3 24.1 33.3 42.6 51.0

23257-07 M 6.6 9.1 NA NA NA NA NA
23257-08 M 6.7 8.5 NA NA NA NA NA
23257-09 M 6.7 9.5 15.1 24.7 33.3 42.0 50.5
23257-10 M 5.9 8.6 NA NA NA NA NA
23257-11 F 6.1 8.8 15.2 24.6 32.1 38.7 47.0
23257-12 F 6.0 8.6 15.1 24.1 32.5 40.7 52.3
23257-13 F 5.0 6.2 NA NA NA NA NA
23257-14 F 6.0 8.1 NA NA NA NA NA
23257-15 F 5.6 8.5 14.5 23.4 33.1 40.4 48.7
23257-16 F 5.3 6.1 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23257-17 F 4.9 5.6 NA NA NA NA NA
MALES MEAN 5.9 8.3 15.2 23.9 32.6 40.2 50.5

FEMALES MEAN 5.6 7.4 14.9 24.0 32.6 39.9 49.3
23234-01 M 6.8 8.1 12.9 20.8 27.5 28.6 41.3

23234-02 M 7.4 9.1 14.4 24.1 32.0 33.2 49.6
23234-03 M 8.1 9.7 14.7 23.6 29.9 30.0 45.7
23234-04 M 7.1 9.0 13.9 22.6 29.9 32.0 44.4
23234-05 F 6.7 8.3 NA NA NA NA NA
Page 1406 of 4796
23234-06 F 6.5 8.3 13.1 21.6 29.6 31.2 43.1

23234-07 F 8.0 9.7 NA NA NA NA NA
23234-08 F 6.6 7.9 12.7 21.3 27.4 28.6 42.3
23234-09 F 6.4 7.4 11.4 19.1 26.8 27.7 40.8
23234-10 F 7.2 8.7 NA NA NA NA NA
23234-11 F 7.5 8.8 NA NA NA NA NA
23234-12 F 7.1 8.7 NA NA NA NA NA
23234-13 F 7.4 9.1 NA NA NA NA NA
23234-14 F 7.2 8.7 13.3 22.2 30.0 32.0 47.7
23234-15 F 7.5 9.3 NA NA NA NA NA
MALES MEAN 7.4 9.0 14.0 22.8 29.8 31.0 45.3

FEMALES MEAN 7.1 8.6 12.6 21.1 28.5 29.9 43.5
23227-01 M 6.4 8.4 NA NA NA NA NA

23227-02 M 7.0 9.1 15.1 23.4 32.0 39.6 50.7
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23227-03 M 6.2 8.2 NA NA NA NA NA
23227-04 M 6.1 7.8 NA NA NA NA NA
23227-05 M 6.5 8.4 14.4 22.7 30.4 35.6 46.5
23227-06 M 6.2 8.1 NA NA NA NA NA
23227-07 M 6.7 8.6 14.6 23.2 31.5 38.5 48.4
23227-08 M 7.1 8.8 NA NA NA NA NA
23227-09 M 6.3 8.7 14.3 22.3 30.7 37.6 47.2
23227-10 M 6.4 8.5 NA NA NA NA NA
23227-11 F 6.1 8.1 13.4 20.9 28.9 35.5 43.4
23227-12 F 6.4 8.0 13.7 21.5 28.8 38.4 42.2
Page 1407 of 4796
23227-13 F 6.6 8.5 NA NA NA NA NA

23227-14 F 6.7 8.5 15.4 23.8 31.7 35.1 48.0
23227-15 F 6.4 8.6 14.4 22.4 31.1 36.9 47.0
23227-16 F 5.6 7.6 NA NA NA NA NA
MALES MEAN 6.5 8.5 14.6 22.9 31.2 37.8 48.2

FEMALES MEAN 6.3 8.2 14.2 22.2 30.1 36.5 45.2
26509-01 M 7.6 10.1 NA NA NA NA NA

26509-02 M 7.3 10.2 16.6 25.5 33.4 40.1 56.3
26509-03 M 7.1 9.9 16.9 26.0 33.3 40.6 52.7
26509-04 M 7.7 10.3 17.3 26.6 35.3 43.1 60.4
26509-05 M 6.6 7.8 11.5 19.2 25.7 32.2 42.7
26509-06 M 7.8 10.4 NA NA NA NA NA
26509-07 M 7.5 9.8 NA NA NA NA NA
26509-08 F 7.0 9.6 16.2 24.7 32.8 38.7 52.7
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26509-09 F 6.5 9.0 NA NA NA NA NA
26509-10 F 6.3 8.0 13.6 20.9 28.3 34.5 46.5
26509-11 F 6.9 9.6 16.5 25.4 32.5 39.6 52.6
26509-12 F 6.5 8.8 NA NA NA NA NA
26509-13 F 6.9 9.0 14.3 22.8 29.7 36.4 49.2
MALES MEAN 7.4 9.8 15.6 24.3 31.9 39.0 53.0

FEMALES MEAN 6.7 9.0 15.2 23.5 30.8 37.3 50.3
26448-01 F 7.1 9.3 NA NA NA NA NA

Page 1408 of 4796
26448-02 M 7.5 10.2 17.7 26.1 33.3 40.4 58.1

26448-03 M 7.9 11.1 NA NA NA NA NA
26448-04 M 7.6 10.3 18.1 26.8 34.9 42.8 55.4
26448-05 M 7.5 10.8 18.5 28.2 36.0 45.3 58.5
26448-06 M 7.8 11.1 NA NA NA NA NA
26448-07 M 7.4 10.3 NA NA NA NA NA
26448-08 M 7.9 10.6 18.5 28.1 35.9 43.7 61.0
26448-09 M 7.8 10.5 NA NA NA NA NA
26448-10 M 6.8 9.9 NA NA NA NA NA
26448-11 F 7.6 10.5 18.4 27.2 34.5 42.7 53.7
26448-12 F 7.6 10.8 18.2 27.0 34.0 43.2 54.5
26448-13 F 7.4 10.1 17.6 26.3 31.7 39.1 54.6
26448-14 F 7.0 9.3 15.9 24.0 30.8 39.1 47.8
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26448-15 F 7.0 10.2 NA NA NA NA NA
MALES MEAN 7.6 10.5 18.2 27.3 35.0 43.1 58.3

FEMALES MEAN 7.3 10.0 17.5 26.1 32.8 41.0 52.7
26508-01 M 6.7 8.2 NA NA NA NA NA

26508-02 M 7.1 8.7 NA NA NA NA NA
26508-03 M 7.0 8.4 13.4 23.1 30.3 38.2 49.1
26508-04 M 7.3 8.5 13.3 22.5 29.6 35.3 47.8
26508-05 M 6.2 6.6 NA NA NA NA NA
Page 1409 of 4796
26508-06 M 6.8 8.0 NA NA NA NA NA

26508-07 M 7.1 9.1 13.5 21.1 27.7 34.2 44.0
26508-08 M 6.7 7.8 11.4 19.2 27.0 34.7 47.1
26508-09 F 6.3 7.4 10.2 17.1 24.1 29.7 40.3
26508-10 F 7.0 8.4 NA NA NA NA NA
26508-11 F 6.5 7.9 12.5 21.3 28.9 35.7 46.6
26508-12 F 6.3 7.8 NA NA NA NA NA
26508-13 F 6.7 7.7 11.9 20.0 27.4 35.0 45.5
26508-14 F 6.4 8.1 12.1 20.0 26.5 34.5 45.4
26508-15 F 6.8 8.2 NA NA NA NA NA
26508-16 F 6.9 8.1 NA NA NA NA NA
MALES MEAN 6.9 8.2 12.9 21.5 28.7 35.6 47.0

FEMALES MEAN 6.6 8.0 11.7 19.6 26.7 33.7 44.5
26463-01 M 6.6 8.8 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26463-02 M 6.6 9.0 15.9 25.4 33.3 41.3 53.8
26463-03 M 6.6 9.1 NA NA NA NA NA
26463-04 M 4.9 6.7 10.9 19.5 28.1 35.7 43.4
26463-05 M 5.6 7.8 NA NA NA NA NA
26463-06 M 6.3 8.9 15.5 25.3 33.2 40.7 52.0
26463-07 M 6.7 9.1 14.5 23.1 30.7 38.3 46.5
26463-08 F 6.2 8.0 13.3 22.4 30.1 36.2 43.2
26463-09 F 6.6 8.8 15.3 25.3 33.9 42.0 49.7
26463-10 F 6.3 8.4 NA NA NA NA NA
26463-11 F 6.0 8.0 NA NA NA NA NA
Page 1410 of 4796
26463-12 F 6.2 8.8 15.1 24.3 33.1 40.4 48.4

26463-13 F 6.7 9.3 NA NA NA NA NA
26463-14 F 6.2 7.8 12.6 21.1 30.1 38.0 44.5
26463-15 F 7.1 9.5 NA NA NA NA NA
MALES MEAN 6.2 8.5 14.2 23.3 31.3 39.0 48.9

FEMALES MEAN 6.4 8.6 14.1 23.3 31.8 39.2 46.5
26504-01 M 7.2 9.4 15.9 24.6 31.5 39.6 50.5

26504-02 M 5.8 7.8 13.0 19.2 26.4 33.1 42.9
26504-03 M 7.0 9.2 16.3 23.0 29.8 37.4 49.3
26504-04 M 6.7 9.4 16.0 23.8 30.8 36.8 48.0
26504-05 M 7.0 9.5 NA NA NA NA NA
26504-06 F 6.2 8.3 NA NA NA NA NA
26504-07 F 6.2 8.5 14.3 21.4 27.0 33.5 43.4
26504-08 F 5.7 8.0 13.7 20.5 26.3 31.1 40.5
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26504-09 F 6.6 9.3 NA NA NA NA NA
26504-10 F 6.5 8.8 15.1 21.9 29.1 35.6 44.6
26504-11 F 5.1 6.8 11.1 16.7 22.0 28.8 37.2
26504-12 F 6.5 9.1 NA NA NA NA NA
26504-13 F 6.2 7.7 NA NA NA NA NA
26504-14 F 6.3 8.9 NA NA NA NA NA
MALES MEAN 6.7 9.1 15.3 22.7 29.6 36.7 47.7

FEMALES MEAN 6.1 8.4 13.6 20.1 26.1 32.3 41.4
Page 1411 of 4796
26465-01 M 6.7 9.8 NA NA NA NA NA

26465-02 M 6.7 9.6 15.2 23.2 30.6 39.6 54.6
26465-04 M 6.9 9.8 16.3 23.6 32.0 39.3 51.8
26465-05 M 7.4 10.3 NA NA NA NA NA
26465-06 M 6.7 9.6 NA NA NA NA NA
26465-07 M 6.8 9.9 NA NA NA NA NA
26465-08 M 7.0 10.2 16.2 24.6 31.3 39.1 52.5
26465-09 M 6.8 9.8 15.7 22.8 30.6 37.4 49.8
26465-10 M 6.9 9.5 15.7 23.6 31.6 39.6 51.8
26465-11 M 6.7 9.5 NA NA NA NA NA
26465-12 F 6.3 9.4 15.7 23.4 29.7 37.0 49.1
26465-13 F 6.6 9.4 15.7 24.0 31.1 39.2 49.2
26465-14 F 6.0 9.1 14.9 23.3 30.5 37.1 49.4
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
MALES MEAN 6.9 9.8 15.8 23.6 31.2 39.0 52.1

FEMALES MEAN 5.4 9.3 15.4 23.6 30.4 37.8 49.2
26477-01 M 8.1 10.7 NA NA NA NA NA

26477-02 M 8.0 10.8 17.1 26.5 34.1 42.4 56.5
26477-03 M 7.4 10.3 16.6 25.3 32.1 37.8 51.4
26477-04 M 7.4 10.0 NA NA NA NA NA
26477-05 M 7.8 10.6 16.5 25.3 33.3 39.8 54.2
Page 1412 of 4796
26477-06 M 8.1 10.8 16.8 25.7 33.8 40.4 53.7

26477-07 F 7.7 10.2 NA NA NA NA NA
26477-08 F 7.2 9.7 15.5 24.5 32.7 40.0 54.4
26477-09 F 7.4 10.5 NA NA NA NA NA
26477-10 F 7.2 9.8 15.0 24.0 30.3 35.5 48.0
26477-11 F 7.4 9.7 15.4 23.0 30.4 37.2 49.7
26477-12 F 6.6 8.9 NA NA NA NA NA
26477-13 F 7.9 11.0 17.1 25.0 33.5 38.8 51.4
MALES MEAN 7.8 10.5 16.8 25.7 33.3 40.1 54.0

FEMALES MEAN 7.3 10.0 15.8 24.1 31.7 37.9 50.9
26511-01 M 7.3 10.7 17.0 25.7 33.4 40.7 54.7

26511-02 M 7.7 10.2 17.3 28.6 37.5 46.6 58.3
26511-03 M 7.2 10.4 NA NA NA NA NA
26511-04 M 7.3 10.6 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26511-05 M 8.0 11.1 17.9 27.9 35.1 42.2 57.4
26511-06 M 7.4 10.4 16.6 26.9 34.9 43.4 55.8
26511-07 F 7.1 10.9 17.5 26.5 33.8 42.6 53.2
26511-08 F 6.4 9.6 NA NA NA NA NA
26511-09 F 6.8 10.0 NA NA NA NA NA
26511-10 F 7.4 10.2 NA NA NA NA NA
26511-11 F 6.8 9.9 16.2 25.4 32.9 39.8 53.6
26511-12 F 7.2 10.4 16.4 25.7 33.2 40.8 51.5
26511-13 F 7.1 10.6 NA NA NA NA NA
26511-14 F 6.2 9.6 15.6 26.2 33.0 40.3 50.9
Page 1413 of 4796
MALES MEAN 7.5 10.6 17.2 27.3 35.2 43.2 56.6

FEMALES MEAN 6.9 10.2 16.4 26.0 33.2 40.9 52.3
26466-01 M 5.8 8.0 NA NA NA NA NA

26466-02 M 6.8 9.1 16.5 25.9 33.6 42.8 57.7
26466-03 M 6.6 9.1 16.3 26.8 35.2 42.5 54.9
26466-04 M 7.2 9.1 NA NA NA NA NA
26466-05 M 7.1 9.1 NA NA NA NA NA
26466-06 M 7.1 9.2 NA NA NA NA NA
26466-07 M 6.6 8.4 NA NA NA NA NA
26466-08 M 6.1 7.9 13.7 22.8 30.6 37.2 48.7
26466-09 M 7.3 9.6 17.2 27.2 33.7 39.8 52.9
26466-10 M 5.9 7.4 NA NA NA NA NA
26466-11 F 5.7 7.2 13.4 21.9 30.0 36.6 48.9
26466-12 F 6.2 8.9 15.4 24.3 31.7 38.8 49.9
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26466-13 F 5.9 7.5 13.4 22.0 29.2 35.2 46.8
26466-14 F 6.0 8.5 NA NA NA NA NA
26466-15 F 6.3 8.6 NA NA NA NA NA
26466-16 F 6.8 8.5 14.2 22.7 30.9 38.4 52.8
26466-17 F 7.1 9.2 NA NA NA NA NA
MALES MEAN 6.7 8.7 15.9 25.7 33.3 40.6 53.6

FEMALES MEAN 6.3 8.3 14.1 22.7 30.5 37.3 49.6
26462-01 M 6.1 7.3 12.2 23.6 34.4 43.6 52.2

Page 1414 of 4796
26462-02 M 6.5 7.7 13.2 24.3 34.2 41.6 50.0

26462-03 M 6.2 7.4 NA NA NA NA NA
26462-04 M 5.9 6.1 6.7 NA NA NA NA
26462-05 M 6.4 6.3 NA NA NA NA NA
26462-06 M 5.8 6.6 11.6 22.4 32.4 43.1 53.4
26462-07 F 6.0 7.4 NA NA NA NA NA
26462-08 F 6.0 6.5 NA NA NA NA NA
26462-09 F 5.6 6.8 11.4 21.7 30.7 38.7 48.1
26462-11 F 5.4 5.7 NA NA NA NA NA
26462-12 F 5.8 7.1 NA NA NA NA NA
26462-13 F 5.8 6.7 11.7 21.2 32.1 42.4 52.3
26462-14 F 6.0 7.2 NA NA NA NA NA
26462-15 F 6.2 7.1 12.2 22.8 31.5 40.2 49.2
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26462-17 F 5.7 5.5 9.1 16.3 24.6 33.7 41.2
MALES MEAN 6.2 6.9 10.9 23.4 33.7 42.8 51.9

FEMALES MEAN 5.9 6.7 11.1 20.5 29.7 38.8 47.7
26523-01 M 5.2 6.7 11.4 19.2 26.7 34.1 43.3

26523-02 M 5.8 7.9 NA NA NA NA NA
26523-04 M 5.7 7.8 NA NA NA NA NA
26523-05 M 6.3 8.1 14.5 22.5 30.3 37.0 48.4
26523-06 M 6.2 7.7 13.2 21.3 27.2 32.8 41.0
Page 1415 of 4796
26523-07 M 5.8 7.8 NA NA NA NA NA

26523-08 M 5.8 7.3 NA NA NA NA NA
26523-09 M 6.0 7.5 12.5 21.0 29.0 35.2 43.8
26523-10 F 5.4 7.3 NA NA NA NA NA
26523-11 F 5.5 7.0 12.5 20.9 27.8 33.3 44.9
26523-12 F 5.9 7.5 NA NA NA NA NA
26523-13 F 5.5 7.1 NA NA NA NA NA
26523-14 F 5.1 6.9 11.5 19.3 27.3 34.8 45.9
26523-15 F 5.8 6.6 NA NA NA NA NA
26523-16 F 5.6 7.7 13.1 21.2 27.9 33.0 42.3
26523-17 F 5.2 6.6 10.8 18.6 25.7 32.1 41.2
MALES MEAN 5.9 7.6 12.9 21.0 28.3 34.8 44.1

FEMALES MEAN 5.5 7.1 12.0 20.0 27.2 33.3 43.6
26470-02 M 6.9 10.0 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A25 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1 4 7 11 14 17 21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26470-03 M 6.3 8.9 NA NA NA NA NA
26470-04 M 6.1 8.7 13.7 22.0 28.7 35.5 44.8
26470-05 M 6.7 9.4 15.7 25.2 31.1 36.9 51.5
26470-06 M 6.5 9.0 14.7 23.5 30.8 38.2 49.5
26470-07 M 6.4 9.3 15.9 25.0 32.3 40.0 52.1
26470-08 F 6.1 8.7 15.2 23.6 30.0 37.5 49.3
26470-09 F 5.6 7.6 12.9 20.9 27.0 31.9 42.1
26470-10 F 6.1 9.3 13.2 24.2 31.2 38.5 50.9
26470-11 F 5.9 8.2 14.6 21.4 28.5 34.4 45.1
26470-12 F 5.8 8.0 NA NA NA NA NA
Page 1416 of 4796
26470-13 F 6.4 9.5 NA NA NA NA NA

26470-14 F 5.9 8.0 NA NA NA NA NA
26470-15 F 5.1 6.7 NA NA NA NA NA
26470-16 F 6.3 9.1 NA NA NA NA NA
26470-17 F 5.1 7.4 NA NA NA NA NA
MALES MEAN 6.5 9.2 15.0 23.9 30.7 37.7 49.5

FEMALES MEAN 5.8 8.3 14.0 22.5 29.2 35.6 46.9
MALES MEAN 6.8 9.0 14.8 23.4 31.1 38.1 49.8

S.D. 0.65 1.15 2.08 2.42 2.85 3.72 5.05
S.E. 0.14 0.24 0.43 0.50 0.59 0.78 1.05
N 23 23 23 23 23 23 23
FEMALES MEAN 6.4 8.4 13.9 22.1 29.6 36.3 46.8

S.D. 0.66 1.09 2.02 2.57 2.86 3.64 4.13
S.E. 0.14 0.23 0.42 0.54 0.60 0.76 0.86
N 23 23 23 23 23 23 23
PPWTNv4.21
07/13/2009
TABLE A26 (F1)
SPONSOR:ACC INDIVIDUAL OFFSPRING WEIGHT CHANGES [G]
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23243-01 M 2.6 5.9 10.1 7.8 7.2 8.4
23243-02 M 2.4 6.9 9.7 7.0 9.0 10.9
23243-03 M 2.7 6.3 10.3 7.4 8.9 7.8
23243-04 M 2.9 NA NA NA NA NA
23243-05 M 2.8 6.0 10.0 7.9 6.7 8.9
23243-06 M 2.5 NA NA NA NA NA
23243-07 M 2.4 NA NA NA NA NA
23243-08 M 2.5 NA NA NA NA NA
23243-09 M 2.9 NA NA NA NA NA
23243-10 F 2.9 6.1 9.8 7.9 7.4 9.8
Page 1417 of 4796
23243-11 F 2.5 NA NA NA NA NA
23243-12 F 2.9 6.4 9.5 7.8 7.6 8.0
23243-13 F 2.2 NA NA NA NA NA
23243-14 F 2.4 6.7 10.5 8.7 7.1 7.8
23243-15 F 1.2 5.4 9.6 8.1 7.7 10.2
MALES MEAN 2.6 6.3 10.0 7.5 8.0 9.0

FEMALES MEAN 2.4 6.2 9.9 8.1 7.5 9.0
23213-02 M 2.5 5.9 10.0 8.5 7.9 10.8

23213-03 M 2.7 6.8 9.6 9.0 6.1 9.9
23213-04 M 2.6 6.2 10.0 8.3 7.9 9.6
23213-05 F 2.7 NA NA NA NA NA
23213-06 F 2.1 NA NA NA NA NA
23213-07 F 2.2 NA NA NA NA NA
23213-08 F 3.0 6.2 9.4 8.4 7.7 10.5
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23213-09 F 2.4 5.6 8.4 8.6 7.6 8.9
23213-10 F 3.0 6.0 10.0 8.5 6.4 10.6
23213-11 F 2.1 NA NA NA NA NA
23213-12 F 2.0 NA NA NA NA NA
23213-13 F 2.6 6.0 10.4 9.1 7.1 10.8
23213-14 F 1.6 NA NA NA NA NA
23213-15 F 2.4 5.9 9.0 8.5 6.4 10.2
MALES MEAN 2.6 6.3 9.9 8.6 7.3 10.1

FEMALES MEAN 2.4 5.9 9.4 8.6 7.0 10.2
Page 1418 of 4796
23203-01 M 1.7 5.1 10.1 9.3 8.1 13.2

23203-02 M 2.1 NA NA NA NA NA
23203-03 M 1.9 NA NA NA NA NA
23203-04 M 2.2 5.4 9.4 7.4 7.0 13.5
23203-05 M 1.0 3.8 8.4 6.9 6.5 8.2
23203-06 M 1.8 NA NA NA NA NA
23203-08 M 1.6 6.2 9.5 7.6 7.7 10.5
23203-09 F 2.4 5.7 10.3 9.2 6.8 12.9
23203-10 F 1.2 NA NA NA NA NA
23203-11 F 1.2 NA NA NA NA NA
23203-12 F 1.1 4.6 10.9 7.0 7.1 12.4
23203-13 F 1.7 5.2 8.5 10.5 8.0 9.9
23203-14 F 1.7 NA NA NA NA NA
23203-15 F 1.1 5.4 7.8 8.8 8.2 8.6
23203-16 F 1.2 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23203-17 F 1.6 NA NA NA NA NA
MALES MEAN 1.8 5.1 9.4 7.8 7.3 11.4

FEMALES MEAN 1.5 5.2 9.4 8.9 7.5 11.0
23207-01 M 2.0 5.8 9.3 7.2 6.3 7.4

23207-02 M 2.8 6.9 10.3 9.2 9.6 7.6
23207-03 M 2.0 6.1 9.0 8.4 7.9 7.1
23207-04 M 2.0 5.3 8.6 8.2 8.8 9.0
23207-05 F 1.6 NA NA NA NA NA
Page 1419 of 4796
23207-06 F 2.2 6.0 8.3 7.2 8.1 8.0

23207-07 F 2.0 NA NA NA NA NA
23207-08 F 1.7 NA NA NA NA NA
23207-09 F 2.3 6.5 9.1 8.2 8.0 8.6
23207-10 F 2.0 0.0 NA NA NA NA
23207-11 F 1.7 NA NA NA NA NA
23207-12 F 2.2 NA NA NA NA NA
23207-13 F 1.9 NA NA NA NA NA
23207-14 F 2.1 5.2 7.9 7.0 6.2 6.5
MALES MEAN 2.2 6.0 9.3 8.3 8.2 7.8

FEMALES MEAN 2.0 4.4 8.4 7.5 7.4 7.7
23226-01 M 1.9 4.5 8.8 9.6 6.5 10.0

23226-02 M 2.1 5.5 9.7 8.0 7.2 11.8
23226-03 M 1.3 3.8 8.7 8.9 7.9 7.8
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23226-04 M 2.0 4.6 10.1 9.5 8.6 11.3
23226-05 F 2.0 4.3 8.9 9.3 6.7 9.1
23226-06 F 1.4 NA NA NA NA NA
23226-07 F 1.1 NA NA NA NA NA
23226-08 F 1.1 3.8 8.5 8.9 6.8 6.6
23226-09 F 1.4 NA NA NA NA NA
23226-10 F 2.5 4.2 9.7 8.5 7.5 10.4
23226-11 F 1.4 NA NA NA NA NA
23226-12 F 1.2 NA NA NA NA NA
23226-13 F 0.9 4.1 8.3 9.3 6.7 8.9
Page 1420 of 4796
23226-15 F 1.8 NA NA NA NA NA
MALES MEAN 1.8 4.6 9.3 9.0 7.6 10.2

FEMALES MEAN 1.5 4.1 8.9 9.0 6.9 8.8
23242-01 M 2.6 NA NA NA NA NA
23242-02 M 1.9 NA NA NA NA NA
23242-03 M 2.1 NA NA NA NA NA
23242-04 M 2.5 5.3 9.3 7.0 6.9 11.6
23242-05 M 2.5 5.8 9.2 8.8 7.4 11.6
23242-06 M 2.3 6.3 10.5 9.3 7.5 12.9
23242-07 M 2.0 NA NA NA NA NA
23242-08 M 1.9 5.9 10.1 8.8 8.6 11.3
23242-09 F 2.3 NA NA NA NA NA
23242-10 F 2.4 NA NA NA NA NA
23242-11 F 2.0 5.8 9.4 9.7 7.7 11.1
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23242-12 F 2.1 NA NA NA NA NA
23242-13 F 2.0 NA NA NA NA NA
23242-14 F 1.8 NA NA NA NA NA
23242-15 F 2.2 5.1 8.9 8.6 6.0 10.4
23242-16 F 1.9 5.7 8.6 8.6 6.5 9.7
23242-17 F 2.6 5.4 9.0 8.6 7.4 8.6
MALES MEAN 2.2 5.8 9.8 8.5 7.6 11.9

FEMALES MEAN 2.1 5.5 9.0 8.9 6.9 10.0
Page 1421 of 4796
23209-01 M 3.3 NA NA NA NA NA
23209-02 M 2.9 NA NA NA NA NA
23209-03 M 3.0 6.7 7.8 7.4 6.2 12.0
23209-04 M 1.9 NA NA NA NA NA
23209-05 M 2.9 6.2 7.6 7.6 6.0 10.1
23209-06 M 2.2 5.8 8.2 9.1 5.4 11.9
23209-07 M 2.2 NA NA NA NA NA
23209-08 M 2.7 4.7 9.7 8.3 7.5 12.5
23209-09 M 2.3 NA NA NA NA NA
23209-10 F 2.4 NA NA NA NA NA
23209-11 F 3.0 NA NA NA NA NA
23209-12 F 3.6 6.4 9.0 9.2 5.9 10.1
23209-13 F 1.7 NA NA NA NA NA
23209-14 F 2.5 5.2 8.4 7.4 6.4 11.7
23209-15 F 3.1 6.6 9.3 8.4 4.9 12.2
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23209-16 F 2.3 6.4 8.5 8.0 4.5 12.7
MALES MEAN 2.6 5.9 8.3 8.1 6.3 11.6

FEMALES MEAN 2.7 6.2 8.8 8.3 5.4 11.7
23178-01 M 3.2 6.9 9.0 9.0 8.1 14.5

23178-02 M 2.4 NA NA NA NA NA
23178-03 M 2.3 5.3 7.6 8.4 5.4 8.8
23178-04 M 2.5 6.3 9.4 8.5 7.7 12.1
23178-05 M 2.4 NA NA NA NA NA
Page 1422 of 4796
23178-06 M 2.4 NA NA NA NA NA
23178-07 M 2.8 6.3 9.0 7.5 7.7 14.4
23178-08 M 2.1 NA NA NA NA NA
23178-09 F 2.6 NA NA NA NA NA
23178-10 F 1.8 NA NA NA NA NA
23178-11 F 2.1 4.9 8.0 8.3 7.2 11.4
23178-12 F 2.1 5.4 8.1 8.5 7.3 7.5
23178-13 F 2.1 5.2 7.8 6.3 6.4 11.3
23178-14 F 2.5 5.7 9.1 7.7 6.8 11.4
23178-15 F 2.5 NA NA NA NA NA
MALES MEAN 2.5 6.2 8.8 8.4 7.2 12.5

FEMALES MEAN 2.2 5.3 8.3 7.7 6.9 10.4
23186-01 M 2.1 6.2 8.4 8.6 6.7 10.1

23186-02 M 1.9 5.8 10.1 6.9 6.9 8.5
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23186-03 M 2.1 5.2 9.0 8.6 6.4 7.4
23186-04 M 2.2 NA NA NA NA NA
23186-05 M 1.7 4.7 8.1 8.1 7.2 7.4
23186-06 M 2.2 NA NA NA NA NA
23186-07 F 1.6 4.8 7.8 7.3 5.7 7.6
23186-08 F 2.1 5.2 8.2 7.1 7.4 7.9
23186-09 F 1.6 5.7 7.9 7.8 7.0 8.2
23186-10 F 2.0 NA NA NA NA NA
23186-11 F 1.8 5.8 9.0 9.2 6.8 7.6
23186-12 F 2.1 NA NA NA NA NA
Page 1423 of 4796
23186-13 F 1.7 NA NA NA NA NA
23186-14 F 2.2 NA NA NA NA NA
MALES MEAN 2.0 5.5 8.9 8.1 6.8 8.4

FEMALES MEAN 1.9 5.4 8.2 7.9 6.7 7.8
23194-01 M 2.0 5.0 8.4 9.9 8.2 9.0

23194-02 M 2.0 NA NA NA NA NA
23194-03 M 0.8 0.2 NA NA NA NA
23194-04 M 2.5 6.0 9.0 8.4 9.8 9.6
23194-05 M 2.1 NA NA NA NA NA
23194-06 M 2.6 6.3 10.8 8.7 8.5 10.6
23194-07 M 2.2 NA NA NA NA NA
23194-08 M 2.4 NA NA NA NA NA
23194-09 F 1.5 NA NA NA NA NA
23194-10 F 1.3 5.4 8.6 7.7 8.8 8.9
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23194-11 F 2.3 NA NA NA NA NA
23194-12 F 1.7 NA NA NA NA NA
23194-13 F 1.8 4.2 8.9 9.1 9.6 8.3
23194-14 F 2.2 NA NA NA NA NA
23194-15 F 1.9 5.0 9.9 10.4 9.3 10.6
23194-17 F 2.1 5.1 8.8 8.4 8.3 10.2
MALES MEAN 2.1 4.4 9.4 9.0 8.8 9.7

FEMALES MEAN 1.9 4.9 9.1 8.9 9.0 9.5
Page 1424 of 4796
23182-01 M 2.1 NA NA NA NA NA
23182-02 M 2.9 NA NA NA NA NA
23182-03 M 3.3 6.9 12.9 7.2 7.9 11.2
23182-04 M 1.9 6.7 11.1 8.1 9.0 3.9
23182-05 M 2.4 6.7 12.3 10.1 8.9 8.3
23182-06 M 2.6 NA NA NA NA NA
23182-07 M 2.5 7.0 12.1 8.4 8.2 11.0
23182-08 F 2.0 NA NA NA NA NA
23182-09 F 2.7 NA NA NA NA NA
23182-10 F 2.2 6.9 10.8 10.2 9.0 8.1
23182-11 F 2.4 5.6 12.4 6.5 7.1 9.1
23182-12 F 1.7 5.5 10.4 7.9 9.0 8.0
23182-13 F 2.1 NA NA NA NA NA
23182-14 F 2.3 NA NA NA NA NA
23182-15 F 1.7 6.9 11.6 7.9 9.9 9.3
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23182-16 F 2.2 NA NA NA NA NA
MALES MEAN 2.5 6.8 12.1 8.5 8.5 8.6

FEMALES MEAN 2.1 6.2 11.3 8.1 8.8 8.6
23240-02 M 3.0 7.3 9.1 7.9 6.3 9.6

23240-03 M 2.4 NA NA NA NA NA
23240-04 M 3.4 NA NA NA NA NA
23240-05 M 2.2 6.8 8.8 7.6 6.1 9.9
23240-06 M 2.6 6.4 9.5 7.3 5.2 9.9
Page 1425 of 4796
23240-07 M 2.4 NA NA NA NA NA
23240-08 M 2.5 7.2 9.2 7.1 7.4 8.2
23240-09 M 3.1 NA NA NA NA NA
23240-10 M 2.4 NA NA NA NA NA
23240-11 M 2.8 NA NA NA NA NA
23240-12 F 1.9 7.2 9.3 6.4 5.2 7.7
23240-13 F 2.5 7.2 9.9 7.0 6.6 8.7
23240-14 F 2.5 6.6 9.5 7.4 6.6 10.2
23240-15 F 3.1 5.9 9.8 6.9 7.2 8.1
MALES MEAN 2.7 6.9 9.2 7.5 6.3 9.4

FEMALES MEAN 2.5 6.7 9.6 6.9 6.4 8.7
26521-02 M 2.4 6.8 9.3 9.2 7.9 12.2

26521-03 M 2.8 6.1 10.0 9.2 6.2 14.3
26521-04 M 2.9 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26521-05 M 2.8 7.1 10.1 9.7 9.4 12.4
26521-06 M 3.2 NA NA NA NA NA
26521-07 M 3.5 NA NA NA NA NA
26521-08 M 2.7 6.2 9.7 9.6 7.2 10.3
26521-09 M 2.6 NA NA NA NA NA
26521-10 M 2.5 NA NA NA NA NA
26521-11 F 2.5 NA NA NA NA NA
26521-12 F 2.6 6.1 9.6 8.1 6.5 10.5
26521-13 F 2.6 NA NA NA NA NA
26521-14 F 2.8 7.5 9.7 9.1 7.3 13.8
Page 1426 of 4796
26521-15 F 2.1 NA NA NA NA NA
26521-16 F 2.5 6.0 9.4 9.3 7.2 12.7
26521-17 F 3.0 6.5 9.4 10.2 7.4 12.3
MALES MEAN 2.8 6.6 9.8 9.4 7.7 12.3

FEMALES MEAN 2.6 6.5 9.5 9.2 7.1 12.3
26449-02 M 2.2 NA NA NA NA NA
26449-03 M 2.6 NA NA NA NA NA
26449-04 M 2.2 NA NA NA NA NA
26449-05 M 2.2 5.8 8.6 7.8 8.4 14.7
26449-06 M 2.7 NA NA NA NA NA
26449-07 M 2.2 6.3 7.7 8.6 6.7 17.7
26449-08 M 2.3 5.8 9.3 8.1 8.6 16.1
26449-09 M 2.8 6.1 9.2 7.8 9.3 15.8
26449-10 M 2.1 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26449-11 F 2.7 NA NA NA NA NA
26449-12 F 2.6 5.8 9.3 8.6 7.8 16.5
26449-13 F 2.3 NA NA NA NA NA
26449-14 F 2.4 5.8 9.3 7.6 8.1 13.8
26449-15 F 2.6 6.0 9.2 7.4 8.1 16.4
26449-16 F 1.8 NA NA NA NA NA
26449-17 F 2.5 6.0 9.3 5.6 7.1 14.2
MALES MEAN 2.4 6.0 8.7 8.1 8.3 16.1

FEMALES MEAN 2.4 5.9 9.3 7.3 7.8 15.2
Page 1427 of 4796
26473-01 M 2.3 NA NA NA NA NA
26473-02 M 2.5 NA NA NA NA NA
26473-03 M 2.2 6.2 9.3 8.3 8.2 16.5
26473-04 M 2.6 6.4 9.2 6.5 6.2 17.9
26473-05 M 2.5 6.2 8.9 7.0 6.7 11.2
26473-06 M 2.7 6.1 9.3 5.7 5.4 15.6
26473-07 M 2.9 NA NA NA NA NA
26473-08 F 2.1 NA NA NA NA NA
26473-09 F 2.0 5.4 8.5 6.8 6.4 15.4
26473-10 F 2.6 5.9 9.1 7.5 6.0 13.4
26473-11 F 2.1 5.8 9.7 7.0 5.5 13.6
26473-12 F 3.1 NA NA NA NA NA
26473-13 F 2.8 6.0 9.1 6.7 6.3 16.3
26473-14 F 2.8 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26473-15 F 2.4 NA NA NA NA NA
MALES MEAN 2.5 6.2 9.2 6.9 6.6 15.3

FEMALES MEAN 2.5 5.8 9.1 7.0 6.1 14.7
26452-02 M 2.9 4.6 10.3 8.3 6.7 11.0

26452-03 M 2.0 7.0 7.2 8.8 10.2 13.2
26452-04 M 2.2 NA NA NA NA NA
26452-05 M 2.6 6.0 10.3 8.0 9.7 12.3
26452-06 M 2.3 NA NA NA NA NA
Page 1428 of 4796
26452-07 M 1.9 NA NA NA NA NA
26452-08 M 2.7 NA NA NA NA NA
26452-09 M 2.4 NA NA NA NA NA
26452-10 M 2.5 NA NA NA NA NA
26452-11 M 2.8 6.8 9.6 10.1 9.1 13.9
26452-12 F 2.9 NA NA NA NA NA
26452-13 F 2.4 5.9 9.2 9.3 10.1 14.0
26452-14 F 2.6 NA NA NA NA NA
26452-15 F 2.4 5.8 7.4 11.1 7.5 12.3
26452-16 F 2.4 5.0 10.6 5.9 7.3 11.6
26452-17 F 2.5 5.6 8.2 8.2 8.6 9.9
MALES MEAN 2.4 6.1 9.4 8.8 8.9 12.6

FEMALES MEAN 2.5 5.6 8.9 8.6 8.4 12.0
26491-01 M 2.8 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26491-02 M 2.9 6.8 9.6 5.9 7.5 19.2
26491-03 M 2.6 7.0 10.2 6.1 7.3 19.3
26491-04 M 2.4 6.4 9.3 4.7 6.4 14.2
26491-05 M 2.6 6.0 9.7 4.9 6.7 17.7
26491-06 M 2.6 NA NA NA NA NA
26491-07 F 2.5 6.5 8.9 5.9 6.1 13.1
26491-08 F 2.5 NA NA NA NA NA
26491-09 F 2.5 6.7 9.5 4.9 6.3 12.6
26491-10 F 2.9 6.7 9.1 5.9 8.7 19.2
26491-11 F 2.3 NA NA NA NA NA
Page 1429 of 4796
26491-12 F 2.2 NA NA NA NA NA
26491-13 F 2.7 NA NA NA NA NA
26491-14 F 3.0 7.5 9.7 4.7 6.6 14.8
MALES MEAN 2.7 6.6 9.7 5.4 7.0 17.6

FEMALES MEAN 2.6 6.9 9.3 5.4 6.9 14.9
26512-01 M 2.9 6.8 10.4 8.2 7.1 17.7

26512-02 M 3.9 5.9 10.1 8.3 7.8 12.6
26512-03 M 3.2 5.4 9.3 7.0 5.9 11.4
26512-04 F 3.1 NA NA NA NA NA
26512-05 F 3.3 6.0 9.1 4.9 10.0 16.2
26512-06 F 2.7 5.9 9.2 7.7 4.7 13.5
26512-07 F 3.2 5.8 9.5 7.8 8.9 13.2
26512-08 F 2.8 NA NA NA NA NA
26512-09 F 2.9 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26512-10 F 3.0 NA NA NA NA NA
26512-11 F 3.1 6.3 7.9 6.2 7.4 14.6
26512-12 F 2.4 NA NA NA NA NA
26512-13 F 3.4 5.4 8.4 7.3 6.6 13.1
MALES MEAN 3.3 6.0 9.9 7.8 6.9 13.9

FEMALES MEAN 3.0 5.9 8.8 6.8 7.5 14.1
26454-01 M 2.2 6.2 9.4 7.2 5.6 11.6

26454-02 M 3.0 6.7 9.9 6.8 4.8 15.7
Page 1430 of 4796
26454-03 M 3.9 NA NA NA NA NA
26454-04 M 3.2 6.7 9.5 7.7 5.9 16.2
26454-05 M 3.8 6.9 11.0 7.9 4.3 12.8
26454-06 F 3.4 NA NA NA NA NA
26454-07 F 3.7 NA NA NA NA NA
26454-08 F 2.9 6.6 9.9 6.4 5.0 16.5
26454-09 F 3.1 NA NA NA NA NA
26454-10 F 3.0 NA NA NA NA NA
26454-11 F 4.1 6.6 10.8 5.5 5.2 16.8
26454-12 F 3.5 NA NA NA NA NA
26454-13 F 2.8 NA NA NA NA NA
26454-14 F 3.1 6.5 8.6 7.9 5.7 15.9
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26454-15 F 3.4 5.9 8.8 6.8 4.6 15.2
MALES MEAN 3.2 6.6 10.0 7.4 5.2 14.1

FEMALES MEAN 3.3 6.4 9.5 6.7 5.1 16.1
26529-01 M 2.7 7.7 12.6 9.8 7.8 17.9

26529-02 M 3.2 7.2 11.4 7.1 6.8 16.0
26529-03 M 3.2 7.8 12.0 8.8 10.0 16.4
26529-04 M 2.9 7.2 11.3 8.6 9.1 15.0
26529-05 M 3.0 NA NA NA NA NA
Page 1431 of 4796
26529-06 F 2.7 NA NA NA NA NA
26529-07 F 1.7 NA NA NA NA NA
26529-08 F 2.7 NA NA NA NA NA
26529-09 F 2.2 NA NA NA NA NA
26529-10 F 2.7 6.7 10.0 7.7 8.1 12.9
26529-11 F 2.9 NA NA NA NA NA
26529-12 F 3.4 7.4 10.7 7.1 7.4 14.9
26529-13 F 2.3 NA NA NA NA NA
26529-14 F 2.4 7.1 10.1 6.7 7.4 14.3
26529-15 F 2.3 NA NA NA NA NA
26529-16 F 3.1 6.5 10.9 8.0 8.2 13.9
MALES MEAN 3.0 7.5 11.8 8.6 8.4 16.3

FEMALES MEAN 2.6 6.9 10.4 7.4 7.8 14.0
26453-01 M 2.1 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26453-02 M 2.0 NA NA NA NA NA
26453-03 M 2.0 NA NA NA NA NA
26453-04 M 2.7 NA NA NA NA NA
26453-05 M 2.1 6.1 9.3 9.3 6.3 12.7
26453-06 M 2.3 NA NA NA NA NA
26453-07 M 2.2 NA NA NA NA NA
26453-08 M 2.5 NA NA NA NA NA
26453-09 M 1.7 5.0 7.4 7.2 4.8 8.5
26453-10 M 2.4 NA NA NA NA NA
26453-11 M 2.1 5.6 8.7 8.8 7.3 12.1
Page 1432 of 4796
26453-12 M 0.6 NA NA NA NA NA
26453-13 M 1.5 5.7 6.5 9.2 8.0 14.0
26453-14 F 2.2 6.3 8.6 8.5 7.6 10.8
26453-15 F 1.8 6.7 8.5 7.7 7.8 12.4
26453-16 F 2.0 5.5 9.0 8.4 7.6 11.0
26453-17 F 3.0 6.8 9.0 7.6 7.2 16.1
MALES MEAN 2.0 5.6 8.0 8.6 6.6 11.8

FEMALES MEAN 2.3 6.3 8.8 8.1 7.6 12.6
26527-01 M 2.6 NA NA NA NA NA
26527-02 M 2.5 NA NA NA NA NA
26527-03 M 3.2 5.1 10.0 8.2 5.3 10.1
26527-04 M 2.7 NA NA NA NA NA
26527-05 M 2.8 6.6 10.1 7.9 6.9 9.2
26527-06 M 2.3 5.2 10.0 8.4 7.1 8.0
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26527-07 M 2.5 6.0 9.6 9.9 7.8 11.0
26527-08 M 2.3 NA NA NA NA NA
26527-09 F 2.3 NA NA NA NA NA
26527-10 F 2.5 NA NA NA NA NA
26527-11 F 2.3 5.3 9.7 8.0 6.8 9.1
26527-12 F 2.5 5.6 9.7 8.8 8.3 10.1
26527-13 F 2.2 5.6 9.6 8.2 7.2 7.5
26527-14 F 2.5 5.0 9.2 8.2 5.1 9.0
MALES MEAN 2.6 5.7 9.9 8.6 6.8 9.6

Page 1433 of 4796
FEMALES MEAN 2.4 5.4 9.6 8.3 6.9 8.9
26489-03 M 2.1 NA NA NA NA NA
26489-04 M 1.6 NA NA NA NA NA
26489-05 M 1.8 NA NA NA NA NA
26489-06 M 1.6 NA NA NA NA NA
26489-07 M 1.9 6.1 11.1 8.5 8.3 7.7
26489-08 M 1.6 4.5 10.4 6.9 7.2 8.8
26489-09 M 1.4 4.4 9.8 6.8 7.5 5.9
26489-10 M 2.5 NA NA NA NA NA
26489-11 M 2.1 5.2 12.3 7.7 7.3 8.7
26489-12 F 2.2 NA NA NA NA NA
26489-13 F 1.9 4.3 11.0 7.2 7.2 7.0
26489-14 F 1.9 NA NA NA NA NA
26489-15 F 1.5 5.8 11.5 8.8 8.4 6.4
26489-16 F 1.5 5.4 9.6 9.1 7.7 8.4
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26489-17 F 1.4 3.8 9.6 6.6 6.6 6.5
26489-18 F 1.7 NA NA NA NA NA
26489-19 F 0.5 NA NA NA NA NA
MALES MEAN 1.8 5.1 10.9 7.5 7.6 7.8

FEMALES MEAN 1.6 4.8 10.4 7.9 7.5 7.1
MALES MEAN 2.4 6.0 9.6 8.1 7.4 11.7

S.D. 0.42 0.73 0.96 0.85 0.91 2.84
Page 1434 of 4796
S.E. 0.09 0.15 0.20 0.18 0.19 0.59

N 23 23 23 23 23 23
FEMALES MEAN 2.3 5.8 9.3 7.9 7.2 11.1

S.D. 0.44 0.75 0.72 0.93 0.92 2.71
S.E. 0.09 0.16 0.15 0.19 0.19 0.57
N 23 23 23 23 23 23
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23195-01 M 2.8 5.8 11.7 8.7 7.1 16.5
23195-02 M 2.4 NA NA NA NA NA
23195-03 M 2.1 NA NA NA NA NA
23195-04 M 2.7 5.6 11.2 9.2 8.2 16.1
23195-05 M 2.7 6.2 11.7 9.3 9.3 13.2
23195-06 M 3.1 6.0 11.1 8.2 6.4 14.8
23195-07 M 3.1 NA NA NA NA NA
23195-08 M 2.6 6.6 9.8 8.8 6.4 10.9
23195-09 M 2.6 NA NA NA NA NA
23195-10 F 2.8 6.7 10.9 7.9 6.6 13.9
Page 1435 of 4796
23195-11 F 2.7 5.9 10.4 9.0 7.6 13.3

23195-12 F 2.5 5.5 11.1 9.0 6.7 12.5
MALES MEAN 2.7 6.0 11.1 8.8 7.5 14.3

FEMALES MEAN 2.7 6.0 10.8 8.6 7.0 13.2
23180-01 M 1.7 NA NA NA NA NA
23180-02 M 2.2 6.8 9.6 8.2 8.1 13.8
23180-03 M 1.6 5.9 7.8 5.0 5.0 12.8
23180-05 M 1.4 NA NA NA NA NA
23180-06 M 2.8 6.3 8.8 7.8 7.9 13.1
23180-07 M 2.1 6.0 10.0 8.5 8.1 14.0
23180-08 M 2.0 NA NA NA NA NA
23180-09 F 2.4 NA NA NA NA NA
23180-10 F 2.2 6.2 8.9 9.1 5.3 12.8
23180-11 F 2.3 6.5 7.2 8.2 6.0 12.1
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23180-12 F 2.0 6.6 9.9 6.7 8.2 14.7
23180-13 F 1.6 NA NA NA NA NA
23180-14 F 1.5 NA NA NA NA NA
23180-15 F 2.0 6.2 8.9 8.9 6.5 12.7
23180-16 F 1.9 NA NA NA NA NA
MALES MEAN 2.0 6.3 9.1 7.4 7.3 13.4

FEMALES MEAN 2.0 6.4 8.7 8.2 6.5 13.1
23176-01 M 1.8 4.5 11.1 9.4 7.7 10.4

Page 1436 of 4796
23176-02 M 1.5 3.8 10.7 8.7 3.1 12.2

23176-03 M 1.3 3.6 9.3 9.1 8.5 7.9
23176-04 M 1.8 NA NA NA NA NA
23176-05 M 1.4 NA NA NA NA NA
23176-06 M 2.2 4.5 11.2 9.8 8.2 8.7
23176-07 M 1.7 NA NA NA NA NA
23176-08 M 2.1 NA NA NA NA NA
23176-09 M 1.0 NA NA NA NA NA
23176-10 F 1.8 4.6 10.1 9.2 6.9 8.2
23176-11 F 1.4 NA NA NA NA NA
23176-12 F 1.4 3.4 9.7 8.2 6.3 7.6
23176-13 F 1.3 3.6 9.6 9.3 7.9 8.2
23176-14 F 1.5 3.9 9.6 9.2 7.7 7.5
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23176-16 F 1.1 NA NA NA NA NA
MALES MEAN 1.6 4.1 10.6 9.3 6.9 9.8

FEMALES MEAN 1.4 3.9 9.8 9.0 7.2 7.9
23251-01 M 3.3 5.4 9.7 9.1 8.7 11.1

23251-02 M 2.5 6.1 10.7 7.4 9.3 12.1
23251-03 M 3.2 NA NA NA NA NA
23251-04 M 3.0 NA NA NA NA NA
23251-05 M 3.2 7.4 8.9 8.9 7.8 14.4
Page 1437 of 4796
23251-06 M 2.9 NA NA NA NA NA
23251-07 M 4.2 NA NA NA NA NA
23251-08 M 3.4 NA NA NA NA NA
23251-09 M 3.2 NA NA NA NA NA
23251-10 M 3.5 6.9 9.7 9.0 8.7 14.5
23251-11 F 2.7 6.7 9.7 9.0 8.6 12.7
23251-12 F 2.7 7.1 10.7 10.4 8.9 10.9
23251-13 F 3.7 7.3 9.4 7.8 6.8 12.6
23251-15 F 3.0 6.5 10.0 9.9 8.8 12.3
MALES MEAN 3.2 6.5 9.8 8.6 8.6 13.0

FEMALES MEAN 3.0 6.9 10.0 9.3 8.3 12.1
23235-04 M 1.5 4.6 8.2 7.3 6.7 7.9

23235-05 M 1.5 3.9 7.4 6.0 5.5 7.7
23235-06 M 2.0 4.2 6.6 5.6 5.5 4.4
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23235-07 F 2.1 5.7 4.3 11.2 6.2 7.6
23235-08 M 1.6 3.7 10.7 3.3 5.6 5.3
23235-09 F 1.9 4.7 7.8 7.1 6.4 9.2
23235-10 F 2.3 5.6 8.5 6.5 5.0 8.5
23235-11 F 2.1 NA NA NA NA NA
23235-12 F 2.6 NA NA NA NA NA
23235-13 F 0.4 NA NA NA NA NA
23235-14 F 2.1 4.9 8.1 7.0 5.6 10.0
23235-15 F 1.7 NA NA NA NA NA
Page 1438 of 4796
MALES MEAN 1.7 4.1 8.2 5.6 5.8 6.3

FEMALES MEAN 1.9 5.2 7.2 8.0 5.8 8.8
23231-01 M 3.6 NA NA NA NA NA
23231-02 M 2.5 NA NA NA NA NA
23231-03 M 3.1 6.4 9.7 6.7 6.7 10.4
23231-04 M 2.5 6.6 9.6 8.7 6.9 11.1
23231-05 M 3.2 NA NA NA NA NA
23231-06 M 2.7 6.0 9.9 8.0 8.2 11.1
23231-07 M 3.0 6.1 10.4 8.0 8.3 10.3
23231-08 M 2.7 NA NA NA NA NA
23231-09 M 2.4 NA NA NA NA NA
23231-10 F 2.6 6.2 10.0 8.0 6.8 11.4
23231-11 F 2.5 6.1 10.5 8.3 6.8 9.9
23231-12 F 2.9 6.1 10.0 7.7 7.1 10.5
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23231-13 F 2.5 5.7 10.8 8.6 7.2 12.4
MALES MEAN 2.9 6.3 9.9 7.9 7.5 10.7

FEMALES MEAN 2.6 6.0 10.3 8.2 7.0 11.1
23216-02 M 3.1 4.8 8.0 9.1 9.3 11.3

23216-03 M 3.4 6.8 10.2 10.0 9.1 10.3
23216-04 M 3.2 NA NA NA NA NA
23216-05 M 3.7 6.8 9.7 9.5 7.6 14.1
23216-06 M 2.7 NA NA NA NA NA
Page 1439 of 4796
23216-07 M 3.6 NA NA NA NA NA
23216-08 M 2.3 6.3 10.5 10.7 9.0 14.9
23216-09 M 2.7 NA NA NA NA NA
23216-10 M 3.3 NA NA NA NA NA
23216-11 F 2.6 6.2 9.1 9.5 5.8 13.0
23216-12 F 3.1 NA NA NA NA NA
23216-13 F 2.6 NA NA NA NA NA
23216-14 F 3.2 NA NA NA NA NA
23216-15 F 3.0 6.3 8.7 11.9 9.3 15.1
23216-16 F 3.5 5.6 9.3 10.0 7.9 11.5
23216-17 F 2.3 5.4 10.7 10.0 9.4 14.4
MALES MEAN 3.1 6.2 9.6 9.8 8.8 12.7

FEMALES MEAN 2.9 5.9 9.5 10.4 8.1 13.5
23261-01 M 2.7 6.2 10.6 9.3 10.0 14.5
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23261-02 M 2.9 6.5 9.0 8.2 7.7 10.7
23261-03 M 2.4 NA NA NA NA NA
23261-04 M 2.6 6.2 8.4 7.0 6.1 14.5
23261-05 M 3.1 6.4 9.6 7.8 7.8 10.5
23261-06 M 2.6 NA NA NA NA NA
23261-07 F 1.7 5.9 8.8 8.3 6.8 10.7
23261-08 F 2.7 NA NA NA NA NA
23261-09 F 2.2 6.7 10.1 8.7 8.1 9.4
23261-10 F 2.0 6.8 8.0 7.4 6.1 6.6
23261-11 F 1.9 NA NA NA NA NA
Page 1440 of 4796
23261-12 F 2.8 6.3 8.9 8.7 8.2 13.4

23261-13 F 2.4 NA NA NA NA NA
MALES MEAN 2.7 6.3 9.4 8.1 7.9 12.6

FEMALES MEAN 2.2 6.4 9.0 8.3 7.3 10.0
23205-01 M 2.0 6.8 9.0 10.0 8.4 15.0

23205-02 M 2.3 7.0 7.5 9.8 9.3 15.3
23205-03 M 2.2 NA NA NA NA NA
23205-04 M 2.2 6.7 8.2 8.9 8.4 15.8
23205-05 M 3.2 8.7 8.9 9.8 11.0 15.0
23205-06 M 2.1 NA NA NA NA NA
23205-07 F 2.5 6.7 8.4 9.9 8.8 15.6
23205-08 F 2.2 NA NA NA NA NA
23205-09 F 2.2 NA NA NA NA NA
23205-10 F 2.3 6.7 8.2 8.9 9.0 14.3
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23205-11 F 2.1 NA NA NA NA NA
23205-12 F 1.8 NA NA NA NA NA
23205-13 F 2.1 NA NA NA NA NA
23205-14 F 1.5 4.5 7.1 8.5 6.4 13.9
23205-15 F 2.4 NA NA NA NA NA
23205-16 F 2.1 6.6 7.5 10.6 8.9 14.7
MALES MEAN 2.3 7.3 8.4 9.6 9.3 15.3

FEMALES MEAN 2.1 6.1 7.8 9.5 8.3 14.6
Page 1441 of 4796
23181-01 M 2.8 NA NA NA NA NA
23181-02 M 2.7 NA NA NA NA NA
23181-03 M 2.9 6.2 11.9 5.2 8.8 12.8
23181-04 M 2.7 5.6 11.7 7.6 7.1 11.1
23181-05 M 2.4 6.7 11.4 8.1 9.2 12.4
23181-07 M 3.3 6.5 13.2 7.5 5.0 12.2
23181-08 F 2.0 4.5 10.2 6.0 6.4 8.7
23181-09 F 2.9 NA NA NA NA NA
23181-10 F 2.0 NA NA NA NA NA
23181-11 F 2.5 5.7 10.1 8.1 9.2 9.6
23181-12 F 2.4 6.3 11.7 6.3 4.8 9.4
23181-13 F 2.4 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23181-14 F 2.1 6.7 11.8 7.1 6.8 10.4
MALES MEAN 2.8 6.3 12.1 7.1 7.5 12.1

FEMALES MEAN 2.3 5.8 11.0 6.9 6.8 9.5
23264-02 M 3.2 5.9 8.5 8.0 6.7 6.9

23264-03 M 2.6 5.2 8.7 8.0 6.5 8.1
23264-04 M 1.7 4.1 7.7 7.5 7.1 7.2
23264-05 M 3.1 5.4 8.4 8.0 8.7 8.9
23264-06 M 2.8 NA NA NA NA NA
Page 1442 of 4796
23264-07 F 2.8 5.5 8.5 7.8 6.2 7.7

23264-08 F 2.4 NA NA NA NA NA
23264-09 F 2.2 NA NA NA NA NA
23264-10 F 2.6 6.5 7.8 7.5 8.1 8.4
23264-11 F 2.1 4.6 8.3 7.1 5.6 6.7
23264-12 F 2.1 NA NA NA NA NA
23264-13 F 2.8 6.1 7.5 7.1 4.6 9.7
23264-14 F 2.5 NA NA NA NA NA
MALES MEAN 2.7 5.2 8.3 7.9 7.3 7.8

FEMALES MEAN 2.4 5.7 8.0 7.4 6.1 8.1
26474-02 M 2.7 6.0 9.5 9.4 8.2 13.2

26474-03 M 2.5 7.2 9.2 7.2 5.9 15.1
26474-04 M 2.3 NA NA NA NA NA
26474-05 M 3.1 6.9 9.4 7.3 6.8 17.3
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26474-06 M 2.5 NA NA NA NA NA
26474-07 M 2.5 NA NA NA NA NA
26474-08 M 2.4 6.0 8.8 7.7 8.0 12.2
26474-09 F 1.9 NA NA NA NA NA
26474-10 F 2.7 NA NA NA NA NA
26474-11 F 2.6 NA NA NA NA NA
26474-12 F 2.5 5.8 9.9 9.2 7.1 10.6
26474-13 F 2.0 4.9 8.0 6.7 7.3 10.1
26474-14 F 1.7 6.5 8.0 6.7 5.9 13.4
26474-15 F 2.4 NA NA NA NA NA
Page 1443 of 4796
26474-16 F 2.4 NA NA NA NA NA
26474-17 F 2.3 4.9 8.6 7.7 7.2 11.4
MALES MEAN 2.6 6.5 9.2 7.9 7.2 14.5

FEMALES MEAN 2.3 5.5 8.6 7.6 6.9 11.4
26476-02 M 3.0 NA NA NA NA NA
26476-03 M 3.5 7.7 11.1 8.1 9.8 20.6
26476-04 M 3.2 NA NA NA NA NA
26476-05 M 3.2 6.7 9.8 7.9 6.8 18.1
26476-06 M 2.2 6.3 9.6 7.5 8.0 14.4
26476-07 M 3.4 NA NA NA NA NA
26476-08 M 3.5 6.9 10.7 8.1 6.8 17.3
26476-09 F 3.0 6.2 9.8 6.4 5.0 14.9
26476-10 F 2.8 NA NA NA NA NA
26476-11 F 2.8 6.6 10.3 7.4 6.9 14.5
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26476-12 F 3.1 NA NA NA NA NA
26476-13 F 2.9 7.0 9.8 8.8 7.5 17.0
26476-14 F 3.1 NA NA NA NA NA
26476-15 F 3.2 NA NA NA NA NA
26476-16 F 2.4 6.7 9.7 7.7 6.1 17.0
MALES MEAN 3.1 6.9 10.3 7.9 7.9 17.6

FEMALES MEAN 2.9 6.6 9.9 7.6 6.4 15.9
26496-01 M 3.5 6.6 9.3 8.7 8.3 13.4

Page 1444 of 4796
26496-02 M 3.1 6.2 9.0 7.2 7.7 17.0

26496-03 M 3.0 6.9 9.8 7.5 9.2 15.6
26496-04 M 2.8 NA NA NA NA NA
26496-05 M 3.0 7.5 9.8 6.9 9.9 14.2
26496-06 F 2.9 7.0 9.7 7.0 7.7 15.6
26496-07 F 3.5 6.6 9.4 8.1 7.6 16.1
26496-08 F 3.1 6.6 9.0 8.3 7.8 15.0
26496-09 F 3.2 NA NA NA NA NA
26496-10 F 3.1 6.7 9.8 8.3 8.0 13.4
26496-11 F 2.9 NA NA NA NA NA
26496-12 F 2.6 NA NA NA NA NA
MALES MEAN 3.1 6.8 9.5 7.6 8.8 15.1

FEMALES MEAN 3.0 6.7 9.5 7.9 7.8 15.0
26505-01 M 3.2 6.1 8.8 6.6 8.1 15.7
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26505-02 M 2.7 NA NA NA NA NA
26505-03 M 2.6 NA NA NA NA NA
26505-04 M 3.6 6.5 9.7 7.8 7.7 18.8
26505-05 M 3.3 6.2 10.0 7.9 8.6 15.4
26505-06 M 2.9 NA NA NA NA NA
26505-07 M 4.2 7.1 10.6 8.5 10.6 16.5
26505-08 M 3.4 NA NA NA NA NA
26505-09 F 3.0 6.3 9.0 6.0 9.2 13.0
26505-10 F 3.1 6.4 9.0 7.0 7.9 12.2
26505-11 F 2.6 5.2 7.8 7.4 6.8 10.7
Page 1445 of 4796
26505-12 F 4.7 6.7 8.3 6.0 6.9 14.3
MALES MEAN 3.2 6.5 9.8 7.7 8.8 16.6

FEMALES MEAN 3.4 6.2 8.5 6.6 7.7 12.6
26483-01 M 3.7 7.0 6.5 4.8 9.3 13.4

26483-02 M 2.9 6.9 11.7 6.6 8.7 14.2
26483-03 M 3.3 NA NA NA NA NA
26483-04 M 3.5 6.2 10.5 7.4 7.3 15.8
26483-05 M 3.5 NA NA NA NA NA
26483-06 M 3.3 NA NA NA NA NA
26483-07 M 3.3 NA NA NA NA NA
26483-08 M 3.3 7.4 11.9 8.3 7.5 14.3
26483-09 F 2.9 6.4 11.0 7.1 7.2 12.1
26483-10 F 2.9 NA NA NA NA NA
26483-11 F 3.4 7.4 11.9 8.4 7.3 13.7
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26483-12 F 3.2 6.8 11.4 7.8 7.7 12.9
26483-13 F 2.8 7.0 10.9 7.0 7.5 11.1
26483-14 F 3.9 NA NA NA NA NA
MALES MEAN 3.4 6.9 10.2 6.8 8.2 14.4

FEMALES MEAN 3.2 6.9 11.3 7.6 7.4 12.5
26479-01 M 2.4 4.0 9.3 7.1 7.6 13.0

26479-02 M 2.5 5.8 9.4 6.9 7.3 13.6
26479-03 M 2.8 5.1 10.1 7.3 7.0 11.3
Page 1446 of 4796
26479-04 M 2.9 NA NA NA NA NA
26479-05 M 2.9 5.9 9.9 8.0 8.3 12.3
26479-06 F 1.5 4.2 7.8 6.6 7.7 8.9
26479-07 F 2.8 4.5 8.7 6.8 6.2 11.5
26479-08 F 2.5 NA NA NA NA NA
26479-09 F 2.7 NA NA NA NA NA
26479-10 F 2.9 4.5 8.6 7.4 8.1 10.0
26479-11 F 2.4 NA NA NA NA NA
26479-12 F 2.5 5.3 8.6 7.9 7.6 12.8
26479-13 F 2.3 NA NA NA NA NA
26479-14 F 2.5 NA NA NA NA NA
MALES MEAN 2.7 5.2 9.7 7.3 7.6 12.6

FEMALES MEAN 2.5 4.6 8.4 7.2 7.4 10.8
26450-01 M 2.7 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26450-02 M 2.5 5.9 8.7 6.9 7.6 12.8
26450-03 M 2.7 NA NA NA NA NA
26450-04 M 4.5 NA NA NA NA NA
26450-05 M 0.7 5.8 9.2 7.6 8.7 8.1
26450-06 M 2.6 6.2 10.6 8.0 8.0 12.8
26450-07 M 3.0 NA NA NA NA NA
26450-08 M 2.8 6.8 10.3 9.1 9.4 8.3
26450-09 M 3.3 NA NA NA NA NA
26450-10 F 3.2 NA NA NA NA NA
26450-11 F 2.3 NA NA NA NA NA
Page 1447 of 4796
26450-12 F 3.1 NA NA NA NA NA
26450-13 F 2.9 NA NA NA NA NA
26450-14 F 3.1 NA NA NA NA NA
26450-15 F 1.9 5.6 9.5 8.2 6.9 11.1
26450-16 F 2.1 6.6 10.4 7.2 8.4 11.5
26450-17 F 2.3 6.4 9.8 7.8 8.5 13.0
26450-18 F 2.8 7.2 9.7 9.8 9.4 12.9
MALES MEAN 2.8 6.2 9.7 7.9 8.4 10.5

FEMALES MEAN 2.6 6.5 9.9 8.3 8.3 12.1
26457-01 M 2.2 NA NA NA NA NA
26457-02 M 1.6 NA NA NA NA NA
26457-03 M 1.4 6.8 10.3 8.2 10.4 11.8
26457-04 M 1.7 6.3 10.1 7.5 7.0 12.8
26457-05 M 2.3 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26457-06 M 2.5 NA NA NA NA NA
26457-07 M 2.2 NA NA NA NA NA
26457-08 M 2.0 NA NA NA NA NA
26457-09 M 1.4 6.3 10.3 8.1 8.8 9.2
26457-10 F 1.5 NA NA NA NA NA
26457-11 F 1.3 4.7 8.8 7.7 8.2 9.3
26457-12 F 1.3 4.9 9.2 7.9 8.4 10.6
26457-13 F 1.6 NA NA NA NA NA
26457-14 F 1.8 5.0 9.2 8.0 9.1 11.0
26457-15 F 1.3 5.0 9.3 7.1 6.0 11.0
Page 1448 of 4796
26457-16 M 1.9 6.2 10.0 8.7 9.3 10.0

26457-17 F 1.9 NA NA NA NA NA
MALES MEAN 1.9 6.4 10.2 8.1 8.9 11.0

FEMALES MEAN 1.5 4.9 9.1 7.7 7.9 10.5
26492-01 M 2.1 NA NA NA NA NA
26492-02 M 1.6 NA NA NA NA NA
26492-03 M 1.9 5.2 9.6 4.0 6.1 8.3
26492-04 M 2.1 NA NA NA NA NA
26492-05 M 1.6 NA NA NA NA NA
26492-06 M 1.4 5.2 8.7 8.0 8.5 9.5
26492-07 M 2.4 6.1 9.6 8.6 9.8 11.3
26492-08 M 2.0 NA NA NA NA NA
26492-09 M 1.4 NA NA NA NA NA
26492-10 F 2.4 6.8 9.6 7.8 7.5 7.2
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26492-11 F 2.3 NA NA NA NA NA
26492-12 F 1.8 4.4 9.5 7.2 7.0 12.5
26492-13 F 2.2 5.7 9.2 6.9 9.8 11.4
26492-14 F 1.5 5.6 9.3 7.5 9.8 10.6
26492-15 F 2.2 NA NA NA NA NA
26492-16 F 2.1 NA NA NA NA NA
26492-17 M 2.0 5.1 9.3 7.0 8.4 9.4
MALES MEAN 1.9 5.4 9.3 6.9 8.2 9.6

FEMALES MEAN 2.1 5.6 9.4 7.4 8.5 10.4
Page 1449 of 4796
26493-02 M 2.2 NA NA NA NA NA
26493-03 M 1.9 NA NA NA NA NA
26493-04 M 1.9 4.5 7.9 7.1 5.9 11.7
26493-05 M 3.4 NA NA NA NA NA
26493-06 M 1.6 6.6 9.1 9.7 6.9 14.8
26493-07 M 3.5 6.7 9.2 9.6 7.3 17.0
26493-08 M 1.5 NA NA NA NA NA
26493-09 M 1.6 NA NA NA NA NA
26493-11 M 2.3 4.6 9.5 9.5 7.8 15.8
26493-12 M 2.6 NA NA NA NA NA
26493-13 F 2.1 NA NA NA NA NA
26493-14 F 2.1 5.2 8.0 8.1 7.7 11.6
26493-15 F 1.3 NA NA NA NA NA
26493-16 F 2.8 5.8 9.7 8.3 8.5 16.5
26493-17 F 2.9 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26493-18 F 1.9 5.2 8.6 7.8 7.7 13.4
26493-19 F 1.2 NA NA NA NA NA
26493-20 F 1.6 4.1 7.8 8.0 7.7 9.9
26493-21 F 1.7 NA NA NA NA NA
MALES MEAN 2.3 5.6 8.9 9.0 7.0 14.8

FEMALES MEAN 2.0 5.1 8.5 8.1 7.9 12.9
26488-04 M 4.1 NA NA NA NA NA
26488-05 M 4.2 7.5 12.2 7.3 6.9 15.7
Page 1450 of 4796
26488-06 M 4.5 7.7 11.5 8.1 8.0 12.9

26488-07 M 4.5 8.0 12.1 6.0 7.5 16.4
26488-08 M 4.4 8.0 11.7 8.0 8.8 13.3
26488-09 F 4.2 7.7 11.2 9.1 6.8 12.8
26488-10 F 4.1 NA NA NA NA NA
26488-11 F 4.3 7.6 12.1 8.1 8.1 11.3
26488-12 F 4.4 7.8 11.8 8.2 8.0 12.1
26488-13 F 4.2 NA NA NA NA NA
26488-14 F 4.2 7.3 12.3 6.6 7.3 12.5
MALES MEAN 4.3 7.8 11.9 7.4 7.8 14.6

FEMALES MEAN 4.2 7.6 11.9 8.0 7.6 12.2
26520-01 M 1.5 7.0 10.0 6.3 7.6 13.5

26520-02 M 1.9 7.2 10.6 8.9 9.2 14.0
26520-03 M 1.4 6.1 10.3 9.1 8.7 12.6
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26520-04 M 1.6 6.1 10.2 8.6 8.7 13.2
26520-05 F 2.0 6.4 10.0 7.7 8.7 9.2
26520-06 F 2.0 NA NA NA NA NA
26520-07 F 1.2 NA NA NA NA NA
26520-08 F 1.9 6.6 10.5 7.7 7.9 9.9
26520-09 F 1.6 NA NA NA NA NA
26520-10 F 1.7 NA NA NA NA NA
26520-11 F 1.3 6.8 10.8 8.4 6.9 14.9
26520-12 F 2.2 NA NA NA NA NA
26520-13 F 2.2 2.1 6.5 8.1 6.9 9.3
Page 1451 of 4796
26520-14 F 2.0 NA NA NA NA NA
26520-15 F 1.9 NA NA NA NA NA
26520-16 F 2.1 NA NA NA NA NA
MALES MEAN 1.6 6.6 10.3 8.2 8.6 13.3

FEMALES MEAN 1.8 5.5 9.5 8.0 7.6 10.8
MALES MEAN 2.6 6.1 9.8 7.9 7.9 12.7

S.D. 0.66 0.89 1.00 0.96 0.82 2.73
S.E. 0.14 0.19 0.21 0.20 0.17 0.57
N 23 23 23 23 23 23
FEMALES MEAN 2.5 5.9 9.4 8.1 7.4 11.7

S.D. 0.64 0.83 1.16 0.86 0.74 2.10
S.E. 0.13 0.17 0.24 0.18 0.15 0.44
N 23 23 23 23 23 23
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23248-02 M 2.5 NA NA NA NA NA
23248-03 M 2.8 NA NA NA NA NA
23248-04 M 2.6 NA NA NA NA NA
23248-05 M 3.5 6.9 9.3 6.6 7.4 8.1
23248-06 M 3.4 6.7 10.6 8.0 10.2 7.4
23248-07 M 2.0 NA NA NA NA NA
23248-08 M 2.7 5.7 8.6 8.0 8.7 8.6
23248-09 M 2.4 7.5 8.3 7.5 7.7 8.2
23248-10 F 1.8 5.5 8.5 7.9 8.7 8.3
23248-11 F 2.4 NA NA NA NA NA
Page 1452 of 4796
23248-12 F 2.7 NA NA NA NA NA
23248-13 F 2.2 6.0 8.4 8.4 7.7 9.1
23248-14 F 2.1 5.9 9.4 7.6 7.0 6.8
23248-15 F 2.2 NA NA NA NA NA
23248-16 F 2.2 5.0 8.3 8.3 8.6 7.3
23248-17 F 2.0 NA NA NA NA NA
MALES MEAN 2.7 6.7 9.2 7.5 8.5 8.1

FEMALES MEAN 2.2 5.6 8.7 8.1 8.0 7.9
23217-01 M 1.6 NA NA NA NA NA
23217-02 M 1.9 NA NA NA NA NA
23217-03 M 2.6 4.8 9.4 8.5 6.2 6.8
23217-04 M 1.3 5.7 8.5 6.5 5.4 7.5
23217-05 M 2.4 NA NA NA NA NA
23217-06 M 1.6 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23217-07 M 2.0 NA NA NA NA NA
23217-08 M 0.9 4.2 7.5 6.9 5.7 5.4
23217-09 M 1.9 5.9 9.4 7.8 7.0 6.2
23217-10 F 2.1 5.4 8.9 7.0 5.8 9.2
23217-11 F 1.2 3.7 6.6 7.0 5.7 7.7
23217-12 F 1.8 NA NA NA NA NA
23217-13 F 1.4 NA NA NA NA NA
23217-14 F 1.2 NA NA NA NA NA
23217-15 F 1.9 NA NA NA NA NA
23217-16 F 2.1 NA NA NA NA NA
Page 1453 of 4796
23217-17 F 1.8 NA NA NA NA NA
23217-18 F 2.2 5.7 8.5 9.0 6.4 6.3
23217-19 F 2.6 NA NA NA NA NA
23217-20 F 2.1 NA NA NA NA NA
23217-21 F 1.7 5.4 8.7 8.5 8.0 7.8
MALES MEAN 1.8 5.2 8.7 7.4 6.1 6.5

FEMALES MEAN 1.8 5.1 8.2 7.9 6.5 7.8
23190-01 M 2.7 6.4 10.7 9.2 7.9 13.5

23190-02 M 2.7 NA NA NA NA NA
23190-03 M 1.4 6.0 9.8 7.6 8.5 12.5
23190-04 M 2.2 6.0 8.6 7.2 6.5 10.6
23190-05 M 2.2 6.2 9.2 8.5 8.1 13.0
23190-06 M 2.2 NA NA NA NA NA
23190-07 M 2.6 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23190-08 F 2.3 6.2 9.8 8.0 7.5 12.1
23190-09 F 2.4 NA NA NA NA NA
23190-10 F 2.5 NA NA NA NA NA
23190-11 F 1.8 NA NA NA NA NA
23190-12 F 1.7 5.3 8.8 7.2 7.0 10.5
23190-13 F 2.2 NA NA NA NA NA
23190-14 F 2.8 NA NA NA NA NA
23190-15 F 2.7 5.7 8.8 8.8 6.6 14.0
23190-16 F 2.6 NA NA NA NA NA
23190-17 F 2.4 6.2 8.9 8.1 6.4 13.1
Page 1454 of 4796
MALES MEAN 2.3 6.2 9.6 8.1 7.8 12.4

FEMALES MEAN 2.3 5.9 9.1 8.0 6.9 12.4
23236-01 M 1.5 3.9 7.9 7.3 8.0 9.6

23236-02 M 1.3 NA NA NA NA NA
23236-03 M 1.6 NA NA NA NA NA
23236-04 M 0.9 NA NA NA NA NA
23236-05 M 1.1 NA NA NA NA NA
23236-06 M 1.4 4.7 7.8 6.0 7.1 9.2
23236-07 M 1.2 4.8 8.6 7.4 6.6 9.6
23236-08 M 0.2 NA NA NA NA NA
23236-09 M 0.5 3.5 8.3 7.6 7.4 6.3
23236-11 F -0.2 NA NA NA NA NA
23236-12 F 0.9 4.0 6.9 5.6 5.2 6.8
23236-13 F 0.8 3.5 7.5 7.5 7.0 4.9
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23236-14 F 1.6 4.6 8.4 7.3 7.2 10.2
23236-15 F 0.6 4.2 8.7 7.7 6.9 7.6
MALES MEAN 1.1 4.2 8.2 7.1 7.3 8.7

FEMALES MEAN 0.7 4.1 7.9 7.0 6.6 7.4
23260-01 M 1.5 4.4 7.1 7.8 5.5 8.7

23260-02 M 1.4 NA NA NA NA NA
23260-03 M 1.6 NA NA NA NA NA
23260-04 M 1.5 4.0 7.2 8.2 6.7 8.3
Page 1455 of 4796
23260-05 M 1.8 NA NA NA NA NA
23260-06 M 1.0 4.6 7.4 6.9 7.2 8.5
23260-07 M 0.8 3.9 6.6 8.2 4.8 10.3
23260-08 F 1.2 NA NA NA NA NA
23260-09 F 1.7 NA NA NA NA NA
23260-10 F 1.1 4.2 6.6 8.6 6.9 10.4
23260-11 F 1.2 3.9 7.0 8.4 6.0 7.7
23260-12 F 1.5 5.1 7.2 5.2 2.4 11.1
23260-13 F 0.8 NA NA NA NA NA
23260-14 F 1.3 4.8 8.0 6.6 7.3 7.7
MALES MEAN 1.4 4.2 7.1 7.8 6.1 9.0

FEMALES MEAN 1.3 4.5 7.2 7.2 5.7 9.2
23221-01 M 2.4 6.4 7.8 7.6 8.7 11.5

23221-02 M 2.9 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23221-03 M 2.4 NA NA NA NA NA
23221-04 M 2.7 6.5 8.5 8.0 8.3 11.7
23221-05 M 3.1 NA NA NA NA NA
23221-06 M 2.4 6.3 9.7 7.8 5.9 14.8
23221-07 M 3.2 5.4 9.6 7.0 8.9 14.5
23221-08 M 2.8 NA NA NA NA NA
23221-09 F 2.5 NA NA NA NA NA
23221-10 F 2.7 6.3 8.6 8.1 8.0 11.9
23221-11 F 2.5 6.1 8.2 7.5 7.9 14.0
23221-12 F 2.5 6.4 8.0 7.2 8.1 14.2
Page 1456 of 4796
23221-13 F 2.5 NA NA NA NA NA
23221-14 F 3.0 6.2 8.3 6.9 5.0 12.1
MALES MEAN 2.7 6.2 8.9 7.6 8.0 13.1

FEMALES MEAN 2.6 6.3 8.3 7.4 7.3 13.1
23263-01 M 2.1 NA NA NA NA NA
23263-02 M 2.6 5.9 9.1 7.8 7.3 7.9
23263-03 M 1.9 NA NA NA NA NA
23263-04 M 2.7 NA NA NA NA NA
23263-05 M 2.1 NA NA NA NA NA
23263-06 M 2.5 6.1 9.1 6.6 7.2 13.0
23263-07 M 2.6 NA NA NA NA NA
23263-08 M 2.6 6.5 9.4 8.7 8.2 10.2
23263-09 M 2.6 6.5 10.0 9.1 8.3 10.7
23263-10 F 2.1 5.5 9.1 6.8 6.3 9.1
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23263-11 F 1.9 NA NA NA NA NA
23263-12 F 2.1 NA NA NA NA NA
23263-13 F 2.1 5.4 8.0 7.7 7.2 12.4
23263-14 F 1.6 4.8 8.7 6.8 7.8 11.9
23263-15 F 2.6 5.2 8.1 7.8 8.4 11.5
MALES MEAN 2.4 6.3 9.4 8.1 7.8 10.5

FEMALES MEAN 2.1 5.2 8.5 7.3 7.4 11.2
23253-02 M 1.5 NA NA NA NA NA
Page 1457 of 4796
23253-03 M 2.3 6.1 8.1 8.3 8.0 14.0

23253-04 M 2.1 5.8 8.3 7.3 5.8 14.0
23253-05 M 2.7 5.7 7.5 8.7 6.5 12.5
23253-06 M 2.8 NA NA NA NA NA
23253-07 M 2.2 NA NA NA NA NA
23253-08 M 2.4 6.5 9.6 9.0 8.9 15.3
23253-09 M 3.1 NA NA NA NA NA
23253-10 M 2.5 NA NA NA NA NA
23253-11 M 2.7 NA NA NA NA NA
23253-12 M 2.8 NA NA NA NA NA
23253-13 F 2.4 NA NA NA NA NA
23253-14 F 1.6 4.9 7.2 8.2 11.8 4.6
23253-15 F 2.2 5.8 8.6 8.6 7.9 9.7
23253-16 F 2.7 6.2 9.4 8.1 7.5 12.6
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23253-17 F 2.7 6.2 8.6 9.2 7.5 11.7
MALES MEAN 2.5 6.0 8.4 8.3 7.3 14.0

FEMALES MEAN 2.3 5.8 8.5 8.5 8.7 9.7
23244-01 M 1.1 3.4 2.8 NA NA NA

23244-02 M 2.4 NA NA NA NA NA
23244-03 M 2.5 NA NA NA NA NA
23244-04 M 2.9 5.8 9.5 8.8 8.9 12.9
23244-05 M 1.0 NA NA NA NA NA
Page 1458 of 4796
23244-06 M 2.3 NA NA NA NA NA
23244-07 M 2.1 4.8 9.3 8.6 9.6 11.1
23244-08 M 1.5 NA NA NA NA NA
23244-09 M 1.7 3.7 8.3 8.6 9.2 10.2
23244-10 M 1.9 NA NA NA NA NA
23244-11 F 2.2 NA NA NA NA NA
23244-12 F 1.8 NA NA NA NA NA
23244-13 F 3.0 5.9 9.3 9.2 10.1 12.0
23244-14 F 0.9 NA NA NA NA NA
23244-15 F 2.4 NA NA NA NA NA
23244-16 F 1.9 6.3 9.3 8.0 9.2 8.1
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23244-17 F 2.0 5.3 9.6 9.9 9.1 9.1
MALES MEAN 1.9 4.4 7.5 8.7 9.2 11.4

FEMALES MEAN 2.0 5.8 9.4 9.0 9.5 9.7
23218-02 M 2.7 NA NA NA NA NA
23218-03 M 2.4 6.2 7.8 9.1 6.8 13.0
23218-04 M 2.9 NA NA NA NA NA
23218-05 M 2.9 6.6 9.1 10.0 9.5 12.2
23218-07 M 2.3 NA NA NA NA NA
Page 1459 of 4796
23218-08 M 2.5 6.0 8.2 9.8 7.3 11.6

23218-09 M 2.0 NA NA NA NA NA
23218-10 F 2.6 NA NA NA NA NA
23218-11 F 2.7 6.7 8.8 9.5 8.2 12.8
23218-12 F 2.7 NA NA NA NA NA
23218-13 F 2.2 NA NA NA NA NA
23218-14 M 2.3 6.1 8.5 8.8 8.0 12.1
23218-15 F 2.3 5.5 9.2 9.9 8.6 10.9
23218-16 F 2.5 5.8 9.4 10.4 6.8 13.1
23218-17 F 2.6 6.2 9.1 10.7 8.0 13.4
MALES MEAN 2.5 6.2 8.4 9.4 7.9 12.2

FEMALES MEAN 2.5 6.1 9.1 10.1 7.9 12.6
23208-01 M 2.5 6.8 7.9 9.0 4.1 22.0

23208-02 M 3.1 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23208-03 M 3.0 NA NA NA NA NA
23208-04 M 3.2 8.0 7.9 10.2 4.6 23.4
23208-05 M 2.4 6.7 7.6 10.8 8.7 13.3
23208-06 M 2.4 NA NA NA NA NA
23208-07 M 2.3 NA NA NA NA NA
23208-08 M 2.9 7.2 6.8 7.7 7.9 13.7
23208-09 F 3.3 NA NA NA NA NA
23208-10 F 2.2 NA NA NA NA NA
23208-11 F 2.1 6.5 6.5 8.5 15.0 3.6
23208-12 F 2.5 6.8 6.7 8.1 11.3 10.6
Page 1460 of 4796
23208-13 F 2.8 7.5 7.6 9.6 5.8 13.2

23208-14 F 2.6 5.3 7.8 9.9 15.7 7.1
MALES MEAN 2.7 7.2 7.6 9.4 6.3 18.1

FEMALES MEAN 2.6 6.5 7.2 9.0 12.0 8.6
23252-01 M 1.1 5.1 10.8 8.7 8.1 8.0

23252-03 M 1.6 5.0 11.3 7.4 6.3 9.7
23252-04 M 1.4 NA NA NA NA NA
23252-05 M 1.5 NA NA NA NA NA
23252-06 M 1.6 2.6 NA NA NA NA
23252-07 M 1.5 5.5 12.8 8.6 8.8 2.4
23252-08 M 1.0 NA NA NA NA NA
23252-09 M 1.3 NA NA NA NA NA
23252-10 M 1.1 NA NA NA NA NA
23252-11 F 0.9 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23252-12 F 1.4 5.0 11.6 7.6 5.8 10.5
23252-13 F 1.5 5.0 11.5 8.3 8.2 7.2
23252-14 F 1.2 NA NA NA NA NA
23252-15 F 1.3 6.2 11.5 8.5 7.6 10.2
23252-16 F 1.3 4.5 8.1 7.2 7.4 7.7
23252-17 F 1.2 NA NA NA NA NA
MALES MEAN 1.3 4.6 11.6 8.2 7.7 6.7

FEMALES MEAN 1.3 5.2 10.7 7.9 7.3 8.9
Page 1461 of 4796
26510-01 M 2.3 NA NA NA NA NA
26510-02 M 2.2 7.5 8.2 6.1 6.9 10.9
26510-03 M 2.8 7.0 8.5 6.0 7.6 11.0
26510-04 M 2.9 NA NA NA NA NA
26510-05 M 2.3 NA NA NA NA NA
26510-06 M 2.8 NA NA NA NA NA
26510-07 M 2.4 NA NA NA NA NA
26510-08 M 2.7 NA NA NA NA NA
26510-09 M 2.1 6.5 7.3 6.0 7.8 7.3
26510-10 M 3.0 NA NA NA NA NA
26510-11 F 2.6 NA NA NA NA NA
26510-12 F 1.9 6.5 8.6 4.4 7.9 10.5
26510-13 F 0.8 3.5 4.8 NA NA NA
26510-14 F 2.5 6.2 7.7 5.3 8.2 NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26510-15 F 2.5 6.6 6.7 5.6 7.1 NA
MALES MEAN 2.6 7.0 8.0 6.0 7.4 9.7

FEMALES MEAN 2.1 5.7 7.0 5.1 7.7 10.5
26519-01 F 2.6 NA NA NA NA NA
26519-03 M 3.0 7.0 9.5 9.7 8.2 14.0
26519-04 M 3.3 7.5 11.3 8.8 8.8 16.1
26519-05 M 2.8 NA NA NA NA NA
26519-06 M 3.0 7.6 11.8 9.3 8.6 13.6
Page 1462 of 4796
26519-07 M 3.4 7.5 11.7 8.7 8.7 15.9

26519-08 F 3.5 7.2 10.2 8.7 8.6 14.0
26519-09 F 3.5 7.0 10.9 8.9 8.2 10.6
26519-10 F 3.1 NA NA NA NA NA
26519-11 F 2.0 6.7 10.9 9.8 8.2 11.0
26519-12 F 3.3 NA NA NA NA NA
26519-13 F 2.8 NA NA NA NA NA
26519-14 F 2.4 NA NA NA NA NA
26519-15 F 2.9 6.5 9.9 8.5 6.9 12.3
MALES MEAN 3.1 7.4 11.1 9.1 8.6 14.9

FEMALES MEAN 2.9 6.9 10.5 9.0 8.0 12.0
26468-02 M 1.5 3.7 2.9 4.0 4.4 4.5

26468-03 M 2.6 7.0 8.2 7.0 7.3 19.2
26468-04 M 3.6 7.0 9.4 7.1 6.5 16.4
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26468-05 M 3.9 6.9 9.4 7.9 8.8 15.5
26468-06 M 3.4 NA NA NA NA NA
26468-07 M 3.5 NA NA NA NA NA
26468-08 M 3.3 NA NA NA NA NA
26468-09 F 3.2 7.0 8.5 7.2 5.5 16.1
26468-10 F 2.8 6.7 8.6 8.2 7.5 15.0
26468-11 F 3.3 NA NA NA NA NA
26468-12 F 3.6 6.6 8.3 6.6 7.5 10.6
26468-13 F 3.2 6.8 8.6 7.0 7.0 13.7
Page 1463 of 4796
MALES MEAN 3.1 6.2 7.5 6.5 6.8 13.9

FEMALES MEAN 3.2 6.8 8.5 7.3 6.9 13.9
26475-01 M 2.9 6.3 10.5 8.0 9.1 13.2

26475-02 M 3.1 5.8 8.9 7.4 6.9 12.0
26475-03 M 2.8 6.8 10.0 6.4 5.8 13.8
26475-04 F 3.0 NA NA NA NA NA
26475-05 M 3.0 6.1 9.0 7.9 7.1 13.4
26475-06 F 3.0 5.9 9.0 7.1 5.7 12.8
26475-07 F 3.0 NA NA NA NA NA
26475-08 F 2.6 NA NA NA NA NA
26475-09 F 2.7 5.9 8.8 6.8 5.8 11.4
26475-10 F 3.0 NA NA NA NA NA
26475-11 F 2.4 NA NA NA NA NA
26475-12 F 3.0 NA NA NA NA NA
26475-13 F 2.5 6.1 9.9 6.3 6.4 12.1
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26475-14 F 3.4 5.9 9.1 8.2 6.0 12.2
MALES MEAN 3.0 6.3 9.6 7.4 7.2 13.1

FEMALES MEAN 2.9 6.0 9.2 7.1 6.0 12.1
26532-01 M 2.0 NA NA NA NA NA
26532-02 M 2.6 NA NA NA NA NA
26532-03 M 2.6 6.6 9.8 8.2 8.4 12.6
26532-04 M 2.4 5.7 9.2 8.4 7.5 12.8
26532-05 M 2.5 NA NA NA NA NA
Page 1464 of 4796
26532-06 M 1.8 6.3 9.8 8.3 7.7 12.4

26532-07 M 2.3 NA NA NA NA NA
26532-08 M 2.4 6.5 10.2 8.9 8.2 8.1
26532-09 F 2.0 NA NA NA NA NA
26532-10 F 2.2 6.7 9.5 8.3 7.9 11.4
26532-11 F 2.7 NA NA NA NA NA
26532-12 F 2.1 NA NA NA NA NA
26532-13 F 2.9 7.0 10.1 9.0 7.1 11.6
26532-14 F 1.6 6.1 9.3 8.3 6.9 9.4
26532-15 F 1.9 NA NA NA NA NA
26532-16 F 2.6 5.9 9.3 7.6 6.0 12.6
MALES MEAN 2.3 6.3 9.8 8.5 8.0 11.5

FEMALES MEAN 2.3 6.4 9.6 8.3 7.0 11.3
26507-01 F 2.4 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26507-02 M 2.8 7.0 9.8 7.8 6.8 13.8
26507-03 M 2.5 6.4 10.1 9.4 7.6 12.6
26507-04 M 2.8 6.5 9.3 7.5 6.2 11.9
26507-05 M 2.7 NA NA NA NA NA
26507-06 M 2.3 NA NA NA NA NA
26507-07 M 2.6 NA NA NA NA NA
26507-08 M 3.0 7.7 10.5 8.2 8.3 10.4
26507-09 M 1.6 NA NA NA NA NA
26507-10 F 2.6 NA NA NA NA NA
26507-11 F 2.6 NA NA NA NA NA
Page 1465 of 4796
26507-12 F 2.7 NA NA NA NA NA
26507-13 F 2.5 6.2 9.7 7.7 6.5 11.7
26507-14 F 2.4 6.8 10.4 7.5 5.9 11.5
26507-15 F 2.6 NA NA NA NA NA
26507-16 F 2.9 7.4 9.8 8.6 8.3 12.2
26507-17 F 2.3 NA NA NA NA NA
26507-18 F 2.2 6.8 9.7 9.1 5.5 11.1
MALES MEAN 2.5 6.9 9.9 8.2 7.2 12.2

FEMALES MEAN 2.5 6.8 9.9 8.2 6.6 11.6
26480-01 M 2.7 NA NA NA NA NA
26480-02 M 4.3 5.8 10.1 9.0 9.7 12.1
26480-03 M 3.8 6.5 10.3 9.4 10.3 11.9
26480-04 M 3.4 6.3 10.3 9.5 10.0 13.3
26480-05 M 3.6 4.9 10.1 8.6 6.8 12.1
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26480-06 M 2.7 NA NA NA NA NA
26480-07 M 3.1 NA NA NA NA NA
26480-09 M 3.9 NA NA NA NA NA
26480-10 F 2.1 NA NA NA NA NA
26480-11 F 3.6 5.9 10.2 9.2 7.1 14.3
26480-12 F 3.9 NA NA NA NA NA
26480-13 F 2.7 4.8 8.2 8.7 9.7 9.5
26480-14 F 3.0 NA NA NA NA NA
26480-15 F 2.3 4.7 9.0 9.2 8.1 9.7
26480-16 F 0.5 1.6 4.1 5.9 6.1 5.8
Page 1466 of 4796
26480-18 F 3.7 NA NA NA NA NA
MALES MEAN 3.4 5.9 10.2 9.1 9.2 12.4

FEMALES MEAN 2.7 4.3 7.9 8.3 7.8 9.8
26482-01 M 3.5 6.5 8.5 6.7 8.3 14.0

26482-02 M 4.0 NA NA NA NA NA
26482-03 M 3.6 7.2 9.4 7.7 7.7 16.6
26482-04 M 3.9 NA NA NA NA NA
26482-05 M 3.6 6.8 9.2 5.6 7.0 18.6
26482-06 M 3.6 6.3 8.8 6.8 7.8 16.7
26482-07 F 3.4 6.7 8.9 7.0 6.7 15.6
26482-08 F 2.9 NA NA NA NA NA
26482-09 F 3.2 NA NA NA NA NA
26482-10 F 3.2 NA NA NA NA NA
26482-11 F 3.4 6.6 9.3 6.7 8.2 15.4
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26482-12 F 2.9 5.6 9.3 7.5 7.5 13.5
26482-13 F 2.9 6.0 9.2 6.2 6.6 15.5
MALES MEAN 3.7 6.7 9.0 6.7 7.7 16.5

FEMALES MEAN 3.1 6.2 9.2 6.9 7.3 15.0
26522-01 M 3.0 7.6 10.2 8.1 7.5 14.0

26522-02 M 3.0 6.8 10.0 7.6 6.8 12.3
26522-03 M 3.1 7.5 10.6 7.6 7.5 15.2
26522-04 M 3.4 7.3 10.6 6.8 5.4 13.3
Page 1467 of 4796
26522-05 F 3.2 7.1 9.2 8.2 6.5 13.1

26522-06 F 3.1 7.0 9.4 7.3 6.3 11.2
26522-07 F 3.1 NA NA NA NA NA
26522-08 F 2.7 NA NA NA NA NA
26522-09 F 2.4 NA NA NA NA NA
26522-10 F 3.0 6.3 10.3 7.4 8.0 12.5
26522-11 F 2.7 NA NA NA NA NA
26522-12 F 3.3 7.0 9.9 7.0 6.1 11.5
26522-13 F 2.8 NA NA NA NA NA
26522-14 F 1.0 NA NA NA NA NA
MALES MEAN 3.1 7.3 10.4 7.5 6.8 13.7

FEMALES MEAN 2.7 6.9 9.7 7.5 6.7 12.1
26517-01 M 2.9 NA NA NA NA NA
26517-02 M 2.4 7.4 8.7 7.3 7.7 13.6
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26517-03 M 3.9 7.2 11.0 7.1 8.6 14.7
26517-04 M 3.7 8.0 10.5 6.3 6.7 16.1
26517-05 M 3.0 7.3 9.5 8.1 7.4 14.7
26517-06 M 2.7 NA NA NA NA NA
26517-07 M 3.0 NA NA NA NA NA
26517-08 F 3.0 7.2 8.4 7.3 7.2 10.9
26517-09 F 3.0 NA NA NA NA NA
26517-10 F 2.7 NA NA NA NA NA
26517-11 F 3.0 NA NA NA NA NA
26517-12 F 3.2 7.1 10.3 8.5 7.8 10.3
Page 1468 of 4796
26517-13 F 3.0 NA NA NA NA NA
26517-14 F 3.3 7.1 11.2 7.5 6.1 15.7
26517-15 F 3.2 NA NA NA NA NA
26517-16 F 3.0 7.2 11.3 7.7 8.4 10.4
MALES MEAN 3.1 7.5 9.9 7.2 7.6 14.8

FEMALES MEAN 3.0 7.2 10.3 7.8 7.4 11.8
26514-01 M 2.9 6.6 10.2 7.4 7.9 11.9

26514-02 M 1.8 NA NA NA NA NA
26514-03 M 2.3 NA NA NA NA NA
26514-04 M 2.7 NA NA NA NA NA
26514-05 M 3.0 NA NA NA NA NA
26514-06 M 2.5 6.5 11.1 7.7 6.6 13.3
26514-07 M 2.8 5.6 10.6 7.5 6.6 16.2
26514-08 M 2.5 5.7 11.1 7.9 8.6 12.9
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26514-09 M 3.1 NA NA NA NA NA
26514-10 F 2.9 NA NA NA NA NA
26514-11 F 2.2 NA NA NA NA NA
26514-12 F 2.3 NA NA NA NA NA
26514-13 F 2.0 4.6 8.9 8.1 6.8 11.4
26514-14 F 2.2 5.3 9.7 7.5 4.9 14.0
26514-15 F 2.5 6.3 9.5 8.3 6.3 14.5
26514-16 F 2.9 5.3 11.5 7.7 7.9 13.7
MALES MEAN 2.6 6.1 10.8 7.6 7.4 13.6

Page 1469 of 4796
FEMALES MEAN 2.4 5.4 9.9 7.9 6.5 13.4
26534-01 M 3.4 7.6 10.2 5.8 5.8 10.3

26534-02 M 2.8 NA NA NA NA NA
26534-03 M 3.0 NA NA NA NA NA
26534-04 M 4.1 7.5 11.2 7.4 7.8 13.9
26534-05 M 3.7 7.2 11.0 8.0 8.6 11.1
26534-06 M 3.3 7.0 10.7 8.1 7.8 10.0
26534-07 F 2.0 NA NA NA NA NA
26534-08 F 3.1 6.3 11.3 7.5 7.4 10.3
26534-09 F 3.7 NA NA NA NA NA
26534-10 F 2.6 6.3 10.9 8.6 7.1 10.5
26534-11 F 2.8 NA NA NA NA NA
26534-12 F 2.6 NA NA NA NA NA
26534-13 F 2.0 6.2 11.0 7.2 8.3 9.2
26534-14 F 3.0 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
26534-15 F 2.5 NA NA NA NA NA
26534-16 F 2.8 7.8 11.1 7.2 6.3 9.4
MALES MEAN 3.4 7.3 10.8 7.3 7.5 11.3

FEMALES MEAN 2.7 6.7 11.1 7.6 7.3 9.9
MALES MEAN 2.6 6.2 9.2 7.9 7.6 12.0

S.D. 0.67 1.00 1.24 0.89 0.82 2.89
S.E. 0.14 0.20 0.25 0.18 0.17 0.59
Page 1470 of 4796
N 24 24 24 24 24 24
FEMALES MEAN 2.3 5.9 9.0 7.9 7.5 10.9

S.D. 0.60 0.85 1.12 0.96 1.27 2.04
S.E. 0.12 0.17 0.23 0.20 0.26 0.42
N 24 24 24 24 24 24
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23179-01 M 2.8 5.9 10.1 7.3 6.7 9.8
23179-02 M 1.9 5.5 11.1 9.7 7.2 11.5
23179-03 M 3.3 6.2 11.8 8.2 8.1 12.7
23179-04 M 3.6 6.6 9.7 5.4 6.8 10.7
23179-05 F 2.5 NA NA NA NA NA
23179-06 F 2.3 4.6 7.9 5.2 5.7 9.9
23179-07 F 2.8 NA NA NA NA NA
23179-08 F 3.4 6.2 10.0 7.1 6.7 14.9
23179-09 F 2.3 5.3 10.2 7.0 5.8 11.8
23179-10 F 2.9 5.4 10.0 6.5 6.2 13.7
Page 1471 of 4796
MALES MEAN 2.9 6.1 10.7 7.7 7.2 11.2

FEMALES MEAN 2.7 5.4 9.5 6.5 6.1 12.6
23212-02 M 1.6 5.2 9.1 9.9 8.2 13.3

23212-03 M 2.2 NA NA NA NA NA
23212-04 M 2.2 NA NA NA NA NA
23212-05 M 2.0 NA NA NA NA NA
23212-06 M 1.7 NA NA NA NA NA
23212-07 M 1.7 5.8 10.8 7.8 7.0 12.7
23212-08 M 1.6 5.6 11.6 8.6 9.2 13.1
23212-09 M 1.8 5.0 9.7 8.8 8.1 12.7
23212-10 F 1.9 NA NA NA NA NA
23212-11 F 2.5 6.1 11.2 7.6 7.1 12.7
23212-12 F 2.4 NA NA NA NA NA
23212-13 F 1.3 NA NA NA NA NA
NA = NOT APPLICABLE
TABLE A26 (F1)
-----------------------------------------------------------------------------------------------------------------------------------
POSTNATAL DAY
PUP NUMBER SEX 1- 4 4- 7 7-11 11-14 14-17 17-21
-----------------------------------------------------------------------------------------------------------------------------------
---------------------------------------
23212-14 F 1.6 NA NA NA NA NA
23212-15 F 1.9 6.0 10.6 9.4 9.8 12.7
23212-16 F 2.4 6.0 11.2 9.0 7.6 10.0
23212-17 F 1.9 5.5 9.9 9.6 8.3 11.1
23212-18 F 2.1 NA NA NA NA NA
MALES MEAN 1.9 5.4 10.3 8.8 8.1 13.0

FEMALES MEAN 2.0 5.9 10.7 8.9 8.2 11.6
23201-02 M 1.2 4.0 7.2 5.8 6.9 6.0

Page 1472 of 4796
23201-03 M 1.5 4.6 7.6 9.2 8.2 11.2

23201-04 M 1.4 4.4 6.7 10.3 6.4 8.8
23201-05 F 1.8 NA NA NA NA NA
23201-06 F 1.7 4.1 7.5 8.8 8.7 9.5
23201-07 F 1.0 NA NA NA NA NA
23201-08 F 1.7 3.0 5.4 4.7 4.9 4.6
23201-09 F 1.5 4.2 7.2 8.9 9.4 9.5
23201-10 F 1.5 NA NA NA NA NA
23201-11 F 1.0 3.9 5.6 7.4 6.4 5.7
23201-13 F 1.4 NA NA NA NA NA
23201-14 F 1.7 3.7 5.8 8.1 6.1 8.1
MALES MEAN 1.4 4.3 7.2 8.4 7.2 8.7

FEMALES MEAN 1.5 3.8 6.3 7.6 7.1 7.5

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FINAL REPORT

U.S. EPA OPPTS Guideline 870.6300

Donald G. Stump, PhD, DABT

STUDY INITIATION DATE

STUDY COMPLETION DATE

WIL Research Laboratories, LLC

Polycarbonate/BPA Global Group

Donald G. Stump, PhD, DABT

Compliance Statement ........................................................................... 2

VOLUME 1 (continued) Page

VOLUME 1 (continued) Page

5.2.9.1. Offspring Not Selected For Behavioral Evaluations (Subset D).............. 49

VOLUME 1 (continued) Page

6.2.4. Body Weights ........................................................................................ 68

VOLUME 1 (continued) Page

6.5.6. Biel Maze Swimming Trials (Subsets A And B) .................................... 82

VOLUME 1 (continued) Page

1. Summary Of Body Weights During Gestation [G] (F0 Females)............................ 107

2. Summary Of Body Weights During Lactation [G] (F0 Females)............................ 108

3. Summary Of Test Substance Consumption During Gestation [Mg/Kg/Day]

4. Summary Of Test Substance Consumption During Lactation [Mg/Kg/Day]

5. Summary Of Offspring Weights [G] (F1 Males) ..................................................... 111

6. Summary Of Offspring Weights [G] (F1 Females).................................................. 112

7. Summary Of Post-Weaning Body Weights [G] (F1 Males) .................................... 113

8. Summary Of Post-Weaning Body Weights [G] (F1 Females)................................. 114

9. Summary Of Motor Activity Total Counts By Session

13. Summary Of Motor Activity Total Counts By Session

14. Summary Of Motor Activity Total Counts By Session

VOLUME 1 (continued) Page

19. Summary Of Biel Maze Data - Mean No. Of Errors

22. Summary Of Biel Maze Data - Mean No. Of Errors

SUMMARY DATA - F0 GENERATION

2. Summary Of Clinical Findings: Total Occurrence/No. Of Animals

3. Summary Of Detailed Clinical Observations (F0 - Gestation) ................................ 142

4. Summary Of Detailed Clinical Observations (F0 - Lactation)................................. 152

5. Summary Of Body Weights During Gestation [G] (F0) .......................................... 164

6. Summary Of Body Weight Changes During Gestation [G] (F0)............................. 166

7. Summary Of Body Weights During Lactation [G] (F0) .......................................... 168

9. Summary Of Food Consumption During Gestation [G/Animal/Day] (F0) ............. 172

11. Summary Of Calculated Gestation Test Substance Consumption

12. Summary Of Calculated Lactation Test Substance Consumption

13. Summary Of Gestation Lengths [Days] (F0) ........................................................... 180

14. Summary Of Macroscopic Findings (F0 - Unscheduled Death).............................. 181

15. Summary Of Macroscopic Findings (F0 - Failed To Deliver)................................. 182

17. Summary Of Macroscopic Findings (F0 - Lactation Day 21).................................. 184

18. Summary Of Implantation Sites (F0)........................................................................ 186

VOLUME 1 (continued) Page

20. Summary Of Microscopic Findings (F0 - Unscheduled Death) .............................. 189

21. Summary Of Microscopic Findings (F0 - Failed To Deliver).................................. 190

SUMMARY DATA - F1 LITTERS

25. Summary Of Postnatal Survival [% Per Litter] (F1) ................................................ 196

26. Summary Of Pup Clinical Observations (F1)........................................................... 198

27. Summary Of Offspring Weights [G] (F1) ................................................................ 200

28. Summary Of Offspring Weight Changes [G] (F1)................................................... 209

29. Summary Of Pup Necropsy Findings

SUMMARY DATA - F1 DEVELOPMENTAL LANDMARKS

32. Summary Of Developmental Landmarks - Balanopreputial Separation

33. Summary Of Developmental Landmarks - Vaginal Patency

VOLUME 1 (continued) Page

SUMMARY DATA - F1 GENERATION

35. Summary Of Clinical Findings: Total Occurrence/No. Of Animals

36. Summary Of Body Weights [G] (F1 - Subset A) ..................................................... 224

39. Summary Of Detailed Clinical Observations (F1 - Subset A) ................................. 234