Lysosomal acid lipase/cholesteryl ester hydrolase (EC:3.1.1.

13)
Short name:
Acid cholesteryl ester hydrolase
Short name:
LAL
Alternative name(s):
Cholesteryl esterase
Lipase A
Sterol esterase
Homo sapiens (Human)
Number of amino acids: 399

GO - Biological processi

cell morphogenesis Source: Ensembl

cell proliferation Source: Ensembl
cytokine production Source: Ensembl
homeostasis of number of cells within a tissue Source: Ensembl
inflammatory response Source: Ensembl
lipid catabolic process Source: UniProtKB-KW
lung development Source: Ensembl
receptor-mediated endocytosis Source: Reactome
tissue remodeling

MKMRFLGLVVCLVLWTLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKG
PKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPA
SINFILNKTGQEQVYYVGHSQGTTIGFIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDK
EFLPQSAFLKWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAVKFQKFQAF
DWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQITNLVFHESIPEWEHLDFIWGLDAPW
RLYNKIINLMRKYQ

Number of amino acids: 399Molecular weight: 45419.01Theoretical pI: 6.42Amino

acid composition:
Ala (A) 22 5.5%Arg (R) 11 2.8%Asn (N) 23 5.8%Asp (D) 20 5.0%Cys (C)
7 1.8%Gln (Q) 14 3.5%Glu (E) 17 4.3%Gly (G) 28 7.0%His (H) 15
3.8%Ile (I) 19 4.8%Leu (L) 43 10.8%Lys (K) 22 5.5%Met (M) 11 2.8%Phe
(F) 24 6.0%Pro (P) 17 4.3%Ser (S) 30 7.5%Thr (T) 20 5.0%Trp (W) 14
3.5%Tyr (Y) 15 3.8%Val (V) 27 6.8%Pyl (O) 0 0.0%Sec (U) 0 0.0% (B)
0 0.0% (Z) 0 0.0% (X) 0 0.0%Total number of negatively charged
residues (Asp + Glu): 37Total number of positively charged residues (Arg +
Lys): 33Atomic composition:Carbon C 2080Hydrogen H
3125Nitrogen N 535Oxygen O 576Sulfur S
18Formula: C2080H3125N535O576S18Total number of atoms: 6334Extinction
coefficients:Extinction coefficients are in units of M-1 cm-1, at 280 nm
measured in water.Ext. coefficient 99725Abs 0.1% (=1 g/l) 2.196,
assuming all pairs of Cys residues form cystinesExt. coefficient 99350Abs
0.1% (=1 g/l) 2.187, assuming all Cys residues are reducedEstimated half-
life:The N-terminal of the sequence considered is M (Met).The estimated half-
life is: 30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo). >10 hours (Escherichia
coli, in vivo).Instability index:The instability index (II) is computed to be
38.14This classifies the protein as stable.Aliphatic index: 85.74Grand
average of hydropathicity (GRAVY): -0.109

Molecular weight (Da): 42859.87 (average mass), 42832.33 (monoisotopic mass)

Theoretical pI: 6.27
9670.6475
8964.3764
8446.0911
7688.8965
6993.4283
6948.4598
6430.1745
6083.9997
5630.8389
5510.7701
5502.7439
5382.6752
5355.5976
5413.6031
5298.5761
5356.5816
5283.5053
5457.5217
5170.4812
5228.4866
4914.5464
4801.4194
4795.2793
4853.2848
4758.4453
4610.1629
4668.1683
4479.2636
4711.2855
4384.1243
4033.9842
4266.0061
4007.9523
3874.9115
3742.7985
3666.9278
3662.7127
3471.6896
3425.7488
3342.7707
3400.7761
3318.6406
3550.6625
3269.6477
3259.4908
3217.7086
3275.7141
3159.5680
2756.3460
2671.4493
2667.4479
2725.4534
2647.2497
2642.4019
2700.4073
2546.1771
2720.1935
2519.1547
2472.2964
2530.3018
2401.2229
2459.2283
2316.1952
2374.2007
2254.0008
2075.0162
2133.0217
2034.9344
1854.9636
1837.0330
1830.8335
2004.8499
1646.7961
1510.8263
1507.8155
1506.8249
1564.8304
1405.8348
1288.6869
1277.7398
1243.5742
1179.6408
1178.6714
1161.7102
1113.5912
887.5495
848.4373
835.5036
759.4545
734.3614
728.3686
720.3423
707.4311
694.3406
600.2736
579.3361
537.3031